

                                SEQUENCE LISTING



<110> NANJING LEGEND BIOTECH CO.,Ltd 
      Fan, Xiaohu
      Wang, Jun
      Wang, Pingyan
      Zhuang,Qiuchuan   



<120> MULTISPECIFIC CHIMERIC RECEPTORS COMPRISING AN NKG2D DOMAIN AND METHODS OF USE THEREOF



<130> 761422000940



<160> 32



<170> FastSEQ for Windows Version 4.0



<210> 1

<211> 19

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 1

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro

 1               5                  10                  15      

Gly Leu Gln

            





<210> 2

<211> 21

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu

 1               5                  10                  15      

His Ala Ala Arg Pro

            20      





<210> 3

<211> 45

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 3

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala

 1               5                  10                  15      

Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly

            20                  25                  30          

Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp

        35                  40                  45  





<210> 4

<211> 24

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 4

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu

 1               5                  10                  15      

Ser Leu Val Ile Thr Leu Tyr Cys

            20                  





<210> 5

<211> 42

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 5

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met

 1               5                  10                  15      

Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe

            20                  25                  30          

Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu

        35                  40          





<210> 6

<211> 112

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 6

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly

 1               5                  10                  15      

Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr

            20                  25                  30          

Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys

        35                  40                  45              

Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys

    50                  55                  60                  

Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg

65                  70                  75                  80  

Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala

                85                  90                  95      

Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg

            100                 105                 110         





<210> 7

<211> 128

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 7

Val Thr Arg Gln Met Cys Ile Tyr Thr Asn Pro Thr Ser Cys Asn Glu

 1               5                  10                  15      

Ile Tyr Gly Lys Phe Ser Ser Ala Tyr Leu Ala Cys Asp Gly Lys Gln

            20                  25                  30          

Met Glu Ile Ile Thr Leu Leu Asn Pro Ser Leu Ile Ser Gly Asp Glu

        35                  40                  45              

Trp Gln Trp Ser Gly Asn Thr Pro Ile His Val Leu Gly Met Trp His

    50                  55                  60                  

Tyr Ser Lys Val Leu Lys Leu Leu Asp Gln Asp Glu Lys Ser Tyr Val

65                  70                  75                  80  

Lys Leu Leu Ser Ala Asn Gln Ser Met Cys Ser Ala Gln Ser Glu Tyr

                85                  90                  95      

Trp Asn Lys Ser Glu Asp Phe Phe Gln Tyr Cys Asn Asn Lys Tyr Cys

            100                 105                 110         

Ile Trp Asn Lys Pro Cys Pro Gly Cys Tyr Ser Glu Thr Leu Pro Ile

        115                 120                 125             





<210> 8

<211> 128

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 8

Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile

 1               5                  10                  15      

Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp

            20                  25                  30          

Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys

        35                  40                  45              

Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr

    50                  55                  60                  

His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp

65                  70                  75                  80  

Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met

                85                  90                  95      

Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile

            100                 105                 110         

Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val

        115                 120                 125             





<210> 9

<211> 135

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 9

Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp Val Asn Cys

 1               5                  10                  15      

Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu

            20                  25                  30          

Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu

        35                  40                  45              

Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala

    50                  55                  60                  

Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn

65                  70                  75                  80  

Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro

                85                  90                  95      

Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr

            100                 105                 110         

Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln Thr Thr Leu

        115                 120                 125             

Ser Leu Ala Ile Phe Thr Ser

    130                 135 





<210> 10

<211> 25

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 10

Lys Glu Glu Leu Glu Ala Glu Lys Arg Asp Leu Ile Arg Thr Asn Glu

 1               5                  10                  15      

Arg Leu Ser Gln Glu Leu Glu Tyr Leu

            20                  25  





<210> 11

<211> 21

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 11

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu

 1               5                  10                  15      

Glu Asn Pro Gly Pro

            20      





<210> 12

<211> 22

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 12

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

 1               5                  10                  15      

Ser Gly Gly Gly Gly Ser

            20          





<210> 13

<211> 22

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 13

Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly

 1               5                  10                  15      

Gly Ser Gly Gly Gly Gly

            20          





<210> 14

<211> 16

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 14

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser

 1               5                  10                  15      





<210> 15

<211> 34

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 15

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly

 1               5                  10                  15      

Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly

            20                  25                  30          

Gly Ser

        





<210> 16

<211> 704

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 16

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro

 1               5                  10                  15      

Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp

            20                  25                  30          

Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln

        35                  40                  45              

Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln

    50                  55                  60                  

Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe

65                  70                  75                  80  

Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile

                85                  90                  95      

Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr

            100                 105                 110         

Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg

        115                 120                 125             

Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln

    130                 135                 140                 

Thr Thr Leu Ser Leu Ala Ile Phe Thr Ser Gly Gly Gly Gly Ser Gly

145                 150                 155                 160 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser

                165                 170                 175     

Arg Arg Val Thr Arg Gln Met Cys Ile Tyr Thr Asn Pro Thr Ser Cys

            180                 185                 190         

Asn Glu Ile Tyr Gly Lys Phe Ser Ser Ala Tyr Leu Ala Cys Asp Gly

        195                 200                 205             

Lys Gln Met Glu Ile Ile Thr Leu Leu Asn Pro Ser Leu Ile Ser Gly

    210                 215                 220                 

Asp Glu Trp Gln Trp Ser Gly Asn Thr Pro Ile His Val Leu Gly Met

225                 230                 235                 240 

Trp His Tyr Ser Lys Val Leu Lys Leu Leu Asp Gln Asp Glu Lys Ser

                245                 250                 255     

Tyr Val Lys Leu Leu Ser Ala Asn Gln Ser Met Cys Ser Ala Gln Ser

            260                 265                 270         

Glu Tyr Trp Asn Lys Ser Glu Asp Phe Phe Gln Tyr Cys Asn Asn Lys

        275                 280                 285             

Tyr Cys Ile Trp Asn Lys Pro Cys Pro Gly Cys Tyr Ser Glu Thr Leu

    290                 295                 300                 

Pro Ile Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly

305                 310                 315                 320 

Gly Ser Gly Ser Gly Gly Gly Gly Ser Ile Pro Leu Thr Glu Ser Tyr

                325                 330                 335     

Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr

            340                 345                 350         

Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys

        355                 360                 365             

Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln

    370                 375                 380                 

Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His

385                 390                 395                 400 

Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser

                405                 410                 415     

Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu

            420                 425                 430         

Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn

        435                 440                 445             

Thr Tyr Ile Cys Met Gln Arg Thr Val Asp Asp Ser Gly Gly Gly Gly

    450                 455                 460                 

Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly

465                 470                 475                 480 

Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile

                485                 490                 495     

Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala

            500                 505                 510         

Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr

        515                 520                 525             

Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu

    530                 535                 540                 

Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile

545                 550                 555                 560 

Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp

                565                 570                 575     

Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu

            580                 585                 590         

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly

        595                 600                 605             

Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr

    610                 615                 620                 

Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys

625                 630                 635                 640 

Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys

                645                 650                 655     

Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg

            660                 665                 670         

Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala

        675                 680                 685             

Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg

    690                 695                 700                 





<210> 17

<211> 700

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 17

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro

 1               5                  10                  15      

Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp

            20                  25                  30          

Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln

        35                  40                  45              

Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln

    50                  55                  60                  

Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe

65                  70                  75                  80  

Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile

                85                  90                  95      

Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr

            100                 105                 110         

Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg

        115                 120                 125             

Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln

    130                 135                 140                 

Thr Thr Leu Ser Leu Ala Ile Phe Thr Ser Gly Gly Gly Gly Ser Gly

145                 150                 155                 160 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser

                165                 170                 175     

Val Thr Arg Gln Met Cys Ile Tyr Thr Asn Pro Thr Ser Cys Asn Glu

            180                 185                 190         

Ile Tyr Gly Lys Phe Ser Ser Ala Tyr Leu Ala Cys Asp Gly Lys Gln

        195                 200                 205             

Met Glu Ile Ile Thr Leu Leu Asn Pro Ser Leu Ile Ser Gly Asp Glu

    210                 215                 220                 

Trp Gln Trp Ser Gly Asn Thr Pro Ile His Val Leu Gly Met Trp His

225                 230                 235                 240 

Tyr Ser Lys Val Leu Lys Leu Leu Asp Gln Asp Glu Lys Ser Tyr Val

                245                 250                 255     

Lys Leu Leu Ser Ala Asn Gln Ser Met Cys Ser Ala Gln Ser Glu Tyr

            260                 265                 270         

Trp Asn Lys Ser Glu Asp Phe Phe Gln Tyr Cys Asn Asn Lys Tyr Cys

        275                 280                 285             

Ile Trp Asn Lys Pro Cys Pro Gly Cys Tyr Ser Glu Thr Leu Pro Ile

    290                 295                 300                 

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

305                 310                 315                 320 

Gly Ser Gly Gly Gly Gly Ser Ile Pro Leu Thr Glu Ser Tyr Cys Gly

                325                 330                 335     

Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe

            340                 345                 350         

Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser

        355                 360                 365             

Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu

    370                 375                 380                 

Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro

385                 390                 395                 400 

Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn

                405                 410                 415     

Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala

            420                 425                 430         

Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr

        435                 440                 445             

Ile Cys Met Gln Arg Thr Val Ser Gly Gly Gly Gly Ser Gly Ser Gly

    450                 455                 460                 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Thr Thr

465                 470                 475                 480 

Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro

                485                 490                 495     

Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val

            500                 505                 510         

His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro

        515                 520                 525             

Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu

    530                 535                 540                 

Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro

545                 550                 555                 560 

Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys

                565                 570                 575     

Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe

            580                 585                 590         

Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu

        595                 600                 605             

Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp

    610                 615                 620                 

Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys

625                 630                 635                 640 

Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala

                645                 650                 655     

Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys

            660                 665                 670         

Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr

        675                 680                 685             

Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg

    690                 695                 700 





<210> 18

<211> 552

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 18

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro

 1               5                  10                  15      

Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp

            20                  25                  30          

Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln

        35                  40                  45              

Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln

    50                  55                  60                  

Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe

65                  70                  75                  80  

Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile

                85                  90                  95      

Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr

            100                 105                 110         

Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg

        115                 120                 125             

Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln

    130                 135                 140                 

Thr Thr Leu Ser Leu Ala Ile Phe Thr Ser Gly Gly Gly Gly Ser Gly

145                 150                 155                 160 

Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly

                165                 170                 175     

Gly Ser Lys Glu Glu Leu Glu Ala Glu Lys Arg Asp Leu Ile Arg Thr

            180                 185                 190         

Asn Glu Arg Leu Ser Gln Glu Leu Glu Tyr Leu Val Thr Arg Gln Met

        195                 200                 205             

Cys Ile Tyr Thr Asn Pro Thr Ser Cys Asn Glu Ile Tyr Gly Lys Phe

    210                 215                 220                 

Ser Ser Ala Tyr Leu Ala Cys Asp Gly Lys Gln Met Glu Ile Ile Thr

225                 230                 235                 240 

Leu Leu Asn Pro Ser Leu Ile Ser Gly Asp Glu Trp Gln Trp Ser Gly

                245                 250                 255     

Asn Thr Pro Ile His Val Leu Gly Met Trp His Tyr Ser Lys Val Leu

            260                 265                 270         

Lys Leu Leu Asp Gln Asp Glu Lys Ser Tyr Val Lys Leu Leu Ser Ala

        275                 280                 285             

Asn Gln Ser Met Cys Ser Ala Gln Ser Glu Tyr Trp Asn Lys Ser Glu

    290                 295                 300                 

Asp Phe Phe Gln Tyr Cys Asn Asn Lys Tyr Cys Ile Trp Asn Lys Pro

305                 310                 315                 320 

Cys Pro Gly Cys Tyr Ser Glu Thr Leu Thr Thr Thr Pro Ala Pro Arg

                325                 330                 335     

Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg

            340                 345                 350         

Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly

        355                 360                 365             

Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr

    370                 375                 380                 

Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg

385                 390                 395                 400 

Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro

                405                 410                 415     

Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu

            420                 425                 430         

Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala

        435                 440                 445             

Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu

    450                 455                 460                 

Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly

465                 470                 475                 480 

Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu

                485                 490                 495     

Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser

            500                 505                 510         

Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly

        515                 520                 525             

Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu

    530                 535                 540                 

His Met Gln Ala Leu Pro Pro Arg

545                 550         





<210> 19

<211> 527

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 19

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro

 1               5                  10                  15      

Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp

            20                  25                  30          

Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln

        35                  40                  45              

Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln

    50                  55                  60                  

Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe

65                  70                  75                  80  

Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile

                85                  90                  95      

Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr

            100                 105                 110         

Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg

        115                 120                 125             

Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln

    130                 135                 140                 

Thr Thr Leu Ser Leu Ala Ile Phe Thr Ser Gly Gly Gly Gly Ser Gly

145                 150                 155                 160 

Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly

                165                 170                 175     

Gly Ser Val Thr Arg Gln Met Cys Ile Tyr Thr Asn Pro Thr Ser Cys

            180                 185                 190         

Asn Glu Ile Tyr Gly Lys Phe Ser Ser Ala Tyr Leu Ala Cys Asp Gly

        195                 200                 205             

Lys Gln Met Glu Ile Ile Thr Leu Leu Asn Pro Ser Leu Ile Ser Gly

    210                 215                 220                 

Asp Glu Trp Gln Trp Ser Gly Asn Thr Pro Ile His Val Leu Gly Met

225                 230                 235                 240 

Trp His Tyr Ser Lys Val Leu Lys Leu Leu Asp Gln Asp Glu Lys Ser

                245                 250                 255     

Tyr Val Lys Leu Leu Ser Ala Asn Gln Ser Met Cys Ser Ala Gln Ser

            260                 265                 270         

Glu Tyr Trp Asn Lys Ser Glu Asp Phe Phe Gln Tyr Cys Asn Asn Lys

        275                 280                 285             

Tyr Cys Ile Trp Asn Lys Pro Cys Pro Gly Cys Tyr Ser Glu Thr Leu

    290                 295                 300                 

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala

305                 310                 315                 320 

Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly

                325                 330                 335     

Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile

            340                 345                 350         

Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val

        355                 360                 365             

Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe

    370                 375                 380                 

Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly

385                 390                 395                 400 

Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg

                405                 410                 415     

Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln

            420                 425                 430         

Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp

        435                 440                 445             

Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro

    450                 455                 460                 

Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp

465                 470                 475                 480 

Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg

                485                 490                 495     

Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr

            500                 505                 510         

Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg

        515                 520                 525         





<210> 20

<211> 553

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 20

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro

 1               5                  10                  15      

Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp

            20                  25                  30          

Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln

        35                  40                  45              

Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln

    50                  55                  60                  

Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe

65                  70                  75                  80  

Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile

                85                  90                  95      

Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr

            100                 105                 110         

Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg

        115                 120                 125             

Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln

    130                 135                 140                 

Thr Thr Leu Ser Leu Ala Ile Phe Thr Ser Gly Gly Gly Gly Ser Gly

145                 150                 155                 160 

Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly

                165                 170                 175     

Gly Ser Lys Glu Glu Leu Glu Ala Glu Lys Arg Asp Leu Ile Arg Thr

            180                 185                 190         

Asn Glu Arg Leu Ser Gln Glu Leu Glu Tyr Leu Ile Pro Leu Thr Glu

        195                 200                 205             

Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn

    210                 215                 220                 

Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala

225                 230                 235                 240 

Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu

                245                 250                 255     

Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu

            260                 265                 270         

Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile

        275                 280                 285             

Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys

    290                 295                 300                 

Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr

305                 310                 315                 320 

Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Thr Thr Thr Pro Ala Pro

                325                 330                 335     

Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu

            340                 345                 350         

Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg

        355                 360                 365             

Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly

    370                 375                 380                 

Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys

385                 390                 395                 400 

Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg

                405                 410                 415     

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro

            420                 425                 430         

Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser

        435                 440                 445             

Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu

    450                 455                 460                 

Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg

465                 470                 475                 480 

Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln

                485                 490                 495     

Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr

            500                 505                 510         

Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp

        515                 520                 525             

Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala

    530                 535                 540                 

Leu His Met Gln Ala Leu Pro Pro Arg

545                 550             





<210> 21

<211> 1443

<212> DNA

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 21

atgagtagac tgcccgtgct gctgctgctg cagctgctgg tgcgccccgg actgcaggcc 60

ccaatgaccc agacaacacc tctgaaaacc tcttgggtga actgcagcaa tatgatcgac 120

gagatcatca cacacctgaa gcagccccct ctgccactgc tggatttcaa caatctgaac 180

ggcgaggacc aggatatcct gatggagaac aatctgagac ggcccaacct ggaggccttt 240

aatagggccg tgaagagcct gcagaacgcc agcgccatcg agtccatcct gaagaatctg 300

ctgccatgtc tgcctctggc aaccgcagca ccaacacgcc acccaatcca catcaaggac 360

ggcgattgga acgagttcag gcgcaagctg accttttacc tgaagacact ggagaatgcc 420

caggcccagc agaccacact gtccctggcc atcttcacct ccggcggcgg cggctctgga 480

ggaggaggaa gcggaggagg aggatctgga tctggcggag gaggctctcg gagagtgaca 540

cggcagatgt gcatctatac caaccccaca agctgtaatg agatctacgg caagtttagc 600

tccgcctatc tggcctgcga cggcaagcag atggagatca tcaccctgct gaacccttct 660

ctgatcagcg gcgatgagtg gcagtggtcc ggcaatacac caatccacgt gctgggcatg 720

tggcactact ctaaggtgct gaagctgctg gaccaggatg agaagtccta tgtgaagctg 780

ctgtctgcca accagtccat gtgctctgcc cagagcgagt actggaataa gagcgaggac 840

ttctttcagt actgcaacaa taagtattgt atctggaaca agccatgccc cggctgttat 900

tccgagacac tgcctatctc tggcggagga ggatccggcg gcggcggctc cggcggcgga 960

ggaagcggct ccggcggcgg cggcagcatc ccactgacag agtcctactg cggcccttgt 1020

ccaaagaatt ggatctgcta caagaacaac tgttaccagt tctttgatga gagcaagaac 1080

tggtatgagt cccaggcctc ttgcatgagc cagaatgcct ctctgctgaa ggtgtacagc 1140

aaggaggacc aggatctgct gaagctggtg aagagctatc actggatggg cctggtgcac 1200

atccccacca acggctcctg gcagtgggag gacggctcca tcctgtctcc taatctgctg 1260

acaatcatcg agatgcagaa gggcgattgt gccctgtacg cctctagctt caagggctat 1320

atcgagaact gctccacccc taatacatac atctgtatgc agcggaccgt ggacgattct 1380

ggcgggggag gcagtgggtc agggggaggg ggaagcggag gaggagggag cggcgggggg 1440

ggc                                                               1443



<210> 22

<211> 1425

<212> DNA

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 22

atgagccgac tgcccgtgct gctgctgctg cagctgctgg tgcgacccgg actgcaggcc 60

cccatgaccc agactacccc actgaaaacc tcttgggtga actgcagcaa tatgatcgac 120

gagatcatca cacacctgaa gcagccccct ctgccactgc tggatttcaa caatctgaac 180

ggcgaggacc aggatatcct gatggagaac aatctgagac ggcccaacct ggaggccttt 240

aatcgggccg tgaagagcct gcagaacgcc agcgccatcg agtccatcct gaagaatctg 300

ctgccatgtc tgcctctggc aaccgcagca ccaacaagac acccaatcca catcaaggac 360

ggcgattgga acgagttcag gcgcaagctg accttttacc tgaagacact ggagaatgcc 420

caggcccagc agaccacact gtccctggcc atcttcacct ccggcggcgg cggctctgga 480

ggaggaggaa gcggaggagg aggatctgga tctggcggag gaggctccgt gacaaggcag 540

atgtgcatct ataccaaccc cacatcttgt aatgagatct acggcaagtt tagctccgcc 600

tatctggcct gcgacggcaa gcagatggag atcatcaccc tgctgaaccc ttctctgatc 660

agcggcgatg agtggcagtg gagcggcaat acaccaatcc acgtgctggg catgtggcac 720

tactccaagg tgctgaagct gctggaccag gatgagaagt cctatgtgaa gctgctgtct 780

gccaaccagt ccatgtgctc tgcccagagc gagtactgga ataagtccga ggacttcttt 840

cagtactgca acaataagta ttgtatctgg aacaagccat gccccggctg ttattctgag 900

acactgccta tctctggcgg aggaggatcc ggcggcggcg gctccggcgg cggaggaagc 960

ggctccggcg gcggcggcag catcccactg acagagtcct actgcggccc ttgtccaaag 1020

aattggatct gctacaagaa caactgttac cagttctttg atgagagcaa gaactggtat 1080

gagtcccagg cctcttgcat gagccagaat gcctctctgc tgaaggtgta cagcaaggag 1140

gaccaggatc tgctgaagct ggtgaagtct tatcactgga tgggcctggt gcacatcccc 1200

accaacggca gctggcagtg ggaggacggc tccatcctgt ctcctaatct gctgacaatc 1260

atcgagatgc agaagggcga ttgtgccctg tacgcctcta gcttcaaggg ctatatcgag 1320

aactgctcca cccctaatac atacatctgt atgcagagaa ccgtgtctgg gggaggggga 1380

agcggaagtg gcggaggcgg ctctggcggg ggaggaagtg gaggg                 1425



<210> 23

<211> 987

<212> DNA

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 23

atgagtagac tgcccgtgct gctgctgctg cagctgctgg tgcgccccgg actgcaggcc 60

ccaatgaccc agacaacccc actgaagacc tcttgggtga actgcagcaa tatgatcgac 120

gagatcatca cacacctgaa gcagccccct ctgccactgc tggatttcaa caatctgaac 180

ggcgaggacc aggatatcct gatggagaac aatctgagac ggcccaacct ggaggccttt 240

aatcgcgccg tgaagtctct gcagaacgcc agcgccatcg agtccatcct gaagaatctg 300

ctgccatgtc tgccactggc aaccgcagca cctacacggc acccaatcca catcaaggac 360

ggcgattgga acgagttcag gcgcaagctg accttttacc tgaagacact ggagaatgcc 420

caggcccagc agaccacact gagcctggcc atcttcacct ccggcggcgg cggctctgga 480

ggaggaggaa gcggcggagg aggaggaggc tctggcagcg gcggcggcgg ctctaaggag 540

gagctggagg ccgagaagcg ggacctgatc agaaccaatg agaggctgag ccaggagctg 600

gagtacctgg tgacacggca gatgtgcatc tataccaacc ctacatcctg taatgagatc 660

tacggcaagt ttagctccgc ctatctggcc tgcgacggca agcagatgga gatcatcacc 720

ctgctgaacc cctccctgat ctctggcgat gagtggcagt ggagcggcaa tacacctatc 780

cacgtgctgg gcatgtggca ctactccaag gtgctgaagc tgctggacca ggatgagaag 840

tcctatgtga agctgctgtc tgccaaccag agcatgtgct ccgcccagtc tgagtactgg 900

aataagtccg aggatttctt tcagtattgt aacaacaaat actgcatctg gaacaaaccc 960

tgtcccggct gctactcaga gaccctg                                     987



<210> 24

<211> 912

<212> DNA

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 24

atgagtagac tgcccgtgct gctgctgctg cagctgctgg tgcgccccgg actgcaggcc 60

ccaatgaccc agacaacccc actgaaaacc tcttgggtga actgcagcaa tatgatcgac 120

gagatcatca cacacctgaa gcagccccct ctgccactgc tggatttcaa caatctgaac 180

ggcgaggacc aggatatcct gatggagaac aatctgagac ggcccaacct ggaggccttt 240

aatcgggccg tgaagtccct gcagaacgcc agcgccatcg agtccatcct gaagaatctg 300

ctgccatgtc tgccactggc aaccgcagca cctacaaggc acccaatcca catcaaggac 360

ggcgattgga acgagttcag gcgcaagctg accttttacc tgaagacact ggagaatgcc 420

caggcccagc agaccacact gtctctggcc atcttcacct ccggcggcgg cggctctgga 480

ggaggaggaa gcggcggagg aggaggaggc tctggcagcg gcggcggcgg cagcgtgaca 540

cggcagatgt gcatctatac caaccctaca tcctgtaatg agatctacgg caagtttagc 600

tccgcctatc tggcctgcga cggcaagcag atggagatca tcaccctgct gaacccctcc 660

ctgatctctg gcgatgagtg gcagtggtct ggcaatacac ctatccacgt gctgggcatg 720

tggcactaca gcaaggtgct gaagctgctg gaccaggatg agaagtccta tgtgaagctg 780

ctgtctgcca accagagcat gtgctccgcc cagtctgagt actggaataa gagcgaggac 840

ttctttcagt attgtaacaa caagtattgc atttggaaca agccctgccc cgggtgctat 900

tctgaaacac tg                                                     912



<210> 25

<211> 990

<212> DNA

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 25

atgagtagac tgcccgtgct gctgctgctg cagctgctgg tgcgacccgg cctgcaggct 60

ccaatgaccc agacaacccc actgaagacc tcttgggtga actgcagcaa tatgatcgac 120

gagatcatca cacacctgaa gcagccccct ctgcctctgc tggatttcaa caatctgaac 180

ggcgaggacc aggatatcct gatggagaac aatctgagac ggcccaacct ggaggccttt 240

aatcgcgccg tgaagagcct gcagaacgcc agcgccatcg agtccatcct gaagaatctg 300

ctgccttgtc tgccactggc aaccgcagca ccaacacggc accctatcca catcaaggac 360

ggcgattgga acgagttcag gcgcaagctg accttttacc tgaagacact ggagaatgcc 420

caggcccagc agaccacact gtccctggcc atcttcacct ccggcggcgg cggctctgga 480

ggaggaggaa gcggcggagg aggaggaggc tctggcagcg gcggcggcgg ctctaaggag 540

gagctggagg ccgagaagcg ggacctgatc agaaccaacg agaggctgag ccaggagctg 600

gagtacctga tccccctgac agagtcctat tgcggcccat gtcccaagaa ttggatctgc 660

tacaagaaca actgttacca gttctttgat gagtccaaga actggtacga gtcccaggcc 720

tcttgcatga gccagaatgc ctccctgctg aaggtgtact ctaaggagga ccaggatctg 780

ctgaagctgg tgaagtctta tcactggatg ggcctggtgc acatcccaac caacggcagc 840

tggcagtggg aggacggctc catcctgtct cccaatctgc tgacaatcat cgagatgcag 900

aagggcgatt gtgccctgta tgccagctcc ttcaaagggt atatcgagaa ttgctccact 960

ccaaacactt acatctgtat gcagcggacc                                  990



<210> 26

<211> 2295

<212> DNA

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 26

atggctctgc ccgtgaccgc cctgctgctg cccctggctc tgctgctgca cgccgcccgc 60

cctgtgacaa gacagatgtg catctatacc aaccccacat cctgcaatga gatctacggc 120

aagttcagct ccgcctatct ggcctgtgac ggcaagcaga tggagatcat caccctgctg 180

aacccatctc tgatcagcgg cgatgagtgg cagtggtccg gcaatacacc catccacgtg 240

ctgggcatgt ggcactactc taaggtgctg aagctgctgg accaggatga gaagtcttat 300

gtgaagctgc tgagcgccaa ccagtccatg tgctctgccc agagcgagta ctggaataag 360

tccgaggact tctttcagta ctgcaacaat aagtattgta tctggaacaa gccatgcccc 420

ggctgttatt ctgagacact gcccatcagc ggaggaggag gatccggcgg aggaggctct 480

ggcggcggcg gctccggctc tggaggagga ggatccatcc ctctgacaga gtcttactgc 540

ggcccttgtc caaagaattg gatctgctac aagaacaact gttaccagtt ctttgatgag 600

tccaagaact ggtatgagtc ccaggcctct tgtatgagcc agaatgccag cctgctgaag 660

gtgtactcca aggaggacca ggatctgctg aagctggtga agagctatca ctggatgggc 720

ctggtgcaca tccctaccaa cggctcctgg cagtgggagg acggctccat cctgtctcca 780

aatctgctga caatcatcga gatgcagaag ggcgattgcg ccctgtacgc ctctagcttc 840

aagggctata tcgagaactg cagcacccca aatacataca tctgtatgca gcgcaccgtg 900

accacaaccc cagcacctcg gccccctacc ccagcaccaa caatcgcaag ccagcctctg 960

tccctgcgcc cagaggcatg taggccagca gcaggaggag cagtgcacac cagaggcctg 1020

gactttgcct gcgatatcta tatctgggca cctctggcag gaacctgtgg cgtgctgctg 1080

ctgagcctgg tcatcaccct gtactgcaag agaggcagga agaagctgct gtatatcttc 1140

aagcagccct ttatgcgccc tgtgcagaca acccaggagg aggacggctg ctcctgtagg 1200

ttcccagaag aggaggaggg aggatgtgag ctgagagtga agtttagcag gtccgccgat 1260

gcacctgcat accagcaggg acagaaccag ctgtataacg agctgaatct gggccggaga 1320

gaggagtacg acgtgctgga taagaggagg ggacgggacc ccgagatggg aggcaagcct 1380

cggagaaaga acccacagga gggcctgtac aatgagctgc agaaggacaa gatggccgag 1440

gcctattctg agatcggcat gaagggagag aggcgccggg gcaagggaca cgatggcctg 1500

taccagggcc tgagcaccgc cacaaaggac acctatgatg ccctgcacat gcaggccctg 1560

ccaccaagag gatctggaga gggaaggggc agcctgctga catgcggcga cgtggaggag 1620

aaccctggcc caatgagcag actgccagtg ctgctgctgc tgcagctgct ggtgaggccc 1680

ggcctgcagg cacctatgac ccagacaacc cccctgaaga caagctgggt gaactgttcc 1740

aatatgatcg acgagatcat cacccacctg aagcagcctc cactgcctct gctggatttc 1800

aacaatctga atggcgagga ccaggatatc ctgatggaga acaatctgag aaggccaaac 1860

ctggaggcct ttaatagagc cgtgaagtct ctgcagaacg cctctgccat cgagagcatc 1920

ctgaagaatc tgctgccttg cctgccactg gcaaccgcag caccaacaag gcaccccatc 1980

cacatcaagg acggcgattg gaacgagttc cgccggaagc tgacctttta cctgaagaca 2040

ctggagaatg cccaggccca gcagacaacc ctgagcctgg ccatcttcac aaccacacca 2100

gcacctcgcc ccccaactcc tgccccaaca atcgcatccc agccactgtc tctgcgcccc 2160

gaggcatgca ggcctgcagc aggcggcgcc gtgcacaccc ggggcctgga ctttgcctgt 2220

gatatctaca tctgggcccc cctggccgga acttgtggcg tcctgctgct gtccctggtc 2280

atcactctgt attgc                                                  2295



<210> 27

<211> 2295

<212> DNA

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<400> 27

atggctctgc ccgtgaccgc cctgctgctg cccctggctc tgctgctgca cgccgcccgc 60

cctgtgacaa gacagatgtg catctatacc aaccccacat cctgcaatga gatctacggc 120

aagttcagct ccgcctatct ggcctgtgac ggcaagcaga tggagatcat caccctgctg 180

aacccatctc tgatcagcgg cgatgagtgg cagtggtccg gcaatacacc catccacgtg 240

ctgggcatgt ggcactactc taaggtgctg aagctgctgg accaggatga gaagtcttat 300

gtgaagctgc tgagcgccaa ccagtccatg tgctctgccc agagcgagta ctggaataag 360

tccgaggact tctttcagta ctgcaacaat aagtattgta tctggaacaa gccatgcccc 420

ggctgttatt ctgagacact gcccatcagc ggaggaggag gatccggcgg aggaggctct 480

ggcggcggcg gctccggctc tggaggagga ggatccatcc ctctgacaga gtcttactgc 540

ggcccttgtc caaagaattg gatctgctac aagaacaact gttaccagtt ctttgatgag 600

tccaagaact ggtatgagtc ccaggcctct tgtatgagcc agaatgccag cctgctgaag 660

gtgtactcca aggaggacca ggatctgctg aagctggtga agagctatca ctggatgggc 720

ctggtgcaca tccctaccaa cggctcctgg cagtgggagg acggctccat cctgtctcca 780

aatctgctga caatcatcga gatgcagaag ggcgattgcg ccctgtacgc ctctagcttc 840

aagggctata tcgagaactg cagcacccca aatacataca tctgtatgca gcgcaccgtg 900

accacaaccc cagcacctcg gccccctacc ccagcaccaa caatcgcaag ccagcctctg 960

tccctgcgcc cagaggcatg taggccagca gcaggaggag cagtgcacac cagaggcctg 1020

gactttgcct gcgatatcta tatctgggca cctctggcag gaacctgtgg cgtgctgctg 1080

ctgagcctgg tcatcaccct gtactgcaag agaggcagga agaagctgct gtatatcttc 1140

aagcagccct ttatgcgccc tgtgcagaca acccaggagg aggacggctg ctcctgtagg 1200

ttcccagaag aggaggaggg aggatgtgag ctgagagtga agtttagcag gtccgccgat 1260

gcacctgcat accagcaggg acagaaccag ctgtataacg agctgaatct gggccggaga 1320

gaggagtacg acgtgctgga taagaggagg ggacgggacc ccgagatggg aggcaagcct 1380

cggagaaaga acccacagga gggcctgtac aatgagctgc agaaggacaa gatggccgag 1440

gcctattctg agatcggcat gaagggagag aggcgccggg gcaagggaca cgatggcctg 1500

taccagggcc tgagcaccgc cacaaaggac acctatgatg ccctgcacat gcaggccctg 1560

ccaccaagag gatctggaga gggaaggggc agcctgctga catgcggcga cgtggaggag 1620

aaccctggcc caatgagcag actgccagtg ctgctgctgc tgcagctgct ggtgaggccc 1680

ggcctgcagg cacctatgac ccagacaacc cccctgaaga caagctgggt gaactgttcc 1740

aatatgatcg acgagatcat cacccacctg aagcagcctc cactgcctct gctggatttc 1800

aacaatctga atggcgagga ccaggatatc ctgatggaga acaatctgag aaggccaaac 1860

ctggaggcct ttaatagagc cgtgaagtct ctgcagaacg cctctgccat cgagagcatc 1920

ctgaagaatc tgctgccttg cctgccactg gcaaccgcag caccaacaag gcaccccatc 1980

cacatcaagg acggcgattg gaacgagttc cgccggaagc tgacctttta cctgaagaca 2040

ctggagaatg cccaggccca gcagacaacc ctgagcctgg ccatcttcac aaccacacca 2100

gcacctcgcc ccccaactcc tgccccaaca atcgcatccc agccactgtc tctgcgcccc 2160

gaggcatgca ggcctgcagc aggcggcgcc gtgcacaccc ggggcctgga ctttgcctgt 2220

gatatctaca tctgggcccc cctggccgga acttgtggcg tcctgctgct gtccctggtc 2280

atcactctgt attgc                                                  2295



<210> 28

<211> 1

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<220> 

<221> VARIANT        

<222> (1)...(1)

<223> can be present in repeat of at least 1



<400> 28

Gly

 1  





<210> 29

<211> 2

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<220> 

<221> VARIANT        

<222> (1)...(2)

<223> can be present in repeat of at least 1



<400> 29

Gly Ser

 1      





<210> 30

<211> 5

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<220> 

<221> VARIANT        

<222> (1)...(5)

<223> can be present in repeat of at least 1



<400> 30

Gly Ser Gly Gly Ser

 1               5  





<210> 31

<211> 4

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<220> 

<221> VARIANT        

<222> (1)...(4)

<223> can be present in repeat of at least 1



<400> 31

Gly Gly Gly Ser

 1              





<210> 32

<211> 5

<212> PRT

<213> Artificial Sequence



<220> 

<223> Synthetic Construct



<220> 

<221> VARIANT        

<222> (1)...(5)

<223> can be present in repeat of at least 1



<400> 32

Gly Gly Gly Gly Ser

 1               5  



