                         SEQUENCE LISTING

<110>  Enzymaster (Ningbo) Bio-Engineering Co., Ltd.
 
<120>  Engineered Transaminase Polypeptides and uses thereof

<130>  EMP046

<160>  400   

<170>  PatentIn version 3.5

<210>  1
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  1
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgcaca gtgacctaac ctatgatgtt      180

atatcggttt gggatggtcg cttctttcga ttggacgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgtgg ttcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg ggttatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaac aaagggactt tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggat ctggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcacaa ctgccggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  2
<211>  323
<212>  PRT
<213>  Aspergillus fumigatus

<400>  2

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Val Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Val Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Thr Lys Gly Leu Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  3
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  3
atggcttcga tggacaaagt cttctcaggt tactacgccc gtcaaaaact gctggaacgc       60

tcagataatc cgttctcaaa aggtattgcc tatgtcgaag gtaaactggt gctgccgagt      120

gatgcgcgca ttccgctgct ggacgaaggc tttatgcata gtgatctgac ctacgacgtt      180

atctccgtct gggacggccg tttctttcgc ctggatgacc acctgcagcg cattctggaa      240

tcatgcgata aaatgcgtct gaaatttccg ctggcactga gctctgtcaa aaatatcctg      300

gcagaaatgg tggctaaaag cggcattcgt gacgctttcg tcgaagtgat cgttacccgc      360

ggcctgacgg gtgttcgtgg ctctaaaccg gaagatctgt ataacaataa catttacctg      420

ctggtgctgc cgtatatctg gctgatggca ccggaaaatc agctgcatgg cggtgaagct      480

attatcaccc gtacggtgcg tcgcaccccg ccgggtgcct ttgatccgac gatcaaaaac      540

ctgcaatggg gtgacctgat taaaggcatg tttgaagcga tggatcgtgg tgccacctat      600

ccgttcctga cggatggcga caccaatctg acggaaggct gcggtttcaa tattgtcctg      660

gtgaaaaacg gtattatcta caccccggat cgtggtgttc tgcgcggcat tacgcgtaaa      720

tcagtgatcg atgttgcgcg cgccaactcg attgacatcc gtctggaagt ggttccggtg      780

gaacaagcgt accactccga tgaaattttc atgtgtacca cggccggcgg tattatgccg      840

atcaccctgc tggatggtca gccggttaac gacggtcaag tcggcccgat taccaagaaa      900

atttgggatg gctattggga aatgcactac aacccggctt attcgtttcc ggtggattat      960

ggcagcggt                                                              969


<210>  4
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  4

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Val Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  5
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  5
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgcaca gtgacgcgac ctatgatgtt      180

atatcggttt gggatggtcg cttctttcga ttggacgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgtgg ttcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggat gcggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcacaa ctgccggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  6
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  6

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Val Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  7
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  7
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgcaca gtgacctaac ctatgatgtt      180

atatcggttt gggatggtcg cttctttcga ttggacgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgtgg ttcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggac ctggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcacaa ctgccggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  8
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  8

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Val Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  9
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  9
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgcaca gtgacctaac ctatgatgtt      180

atatcggttt gggatggtcg cttctttcga ttggacgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgtgg ttcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggaa gtggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcacaa ctgccggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  10
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  10

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Val Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  11
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  11
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgcaca gtgacctaac ctatgatgtt      180

atatcggttt gggatggtcg cttctttcga ttggacgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgtgg ttcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggat gcggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tggaggggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcacaa ctgccggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  12
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  12

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Val Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  13
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  13
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgcaca gtgacctaac ctatgatgtt      180

atatcggttt gggatggtcg cttctttcga ttggacgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgtgg ttcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggat gcggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgctcga ctgccggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  14
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  14

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Val Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  15
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  15
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgcata gtgacctaac ctatgatacc      180

atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgtgg ctcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggac cgggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcagca ctggcggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  16
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  16

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  17
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  17
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgacca gtgacctaac ctatgatacc      180

atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgtgg ctcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggac cgggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcagca ctgccggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  18
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  18

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  19
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  19
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgacca gtgacctaac ctatgatacc      180

atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgatgg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgttt ttcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggac cgggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcagca ctgccggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggtccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  20
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  20

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Phe Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  21
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  21
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgcata gtgacctaac ctatgatacc      180

atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgtgg ctcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggac cgggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcacca ctgccggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  22
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  22

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  23
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  23
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgccta gtgacctaac ctatgatacc      180

atatcggttt gggatggtcg cttctttcga ttgggcgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgatgg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgtgg ctcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggat gcggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcagca ctgccggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  24
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  24

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Pro Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Gly Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  25
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  25
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgcata gtgacctaac ctatgatacc      180

atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgtgg ctcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggac cgggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcagca ctgccggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  26
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  26

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  27
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  27
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgcata gtgacctaac ctatgatacc      180

atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgatgg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgtgg ctcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggat gcggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcagca ctgccggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  28
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  28

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  29
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  29
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgcata gtgacctaac ctatgatacc      180

atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgatgg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgttt ttcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggat gcggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcagca ctgccggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  30
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  30

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Phe Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  31
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  31
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgacca gtgacctaac ctatgatacc      180

atatcggttt gggatggtcg cttctttcga ttggatgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgtttg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgtgg ctcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggac cgggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcagca ctggcggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  32
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  32

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Phe Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  33
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  33
atggcctcta tggacaaagt cttttcggga tattatgcgc gccagaagct gcttgaacgg       60

agcgacaatc ctttctctaa gggcattgct tatgtggaag gaaagctcgt cttacctagt      120

gatgctagaa taccgctact cgacgaaggt ttcatgcaca gtgacctaac ctatgatgtt      180

atatcggttt gggatggtcg cttctttcga ttggacgatc atttgcaacg gattttggaa      240

agctgcgata agatgcggct caagttccca cttgcactga gctcagtgaa aaatattctg      300

gctgagatgg tcgccaagag tggtatccgg gatgcgtggg tggaagttat tgtgacacgt      360

ggtctgacag gtgtacgtgg ttcgaagcct gaggatctgt ataataacaa catatacctg      420

cttgttcttc catacatttg gctgatggcg cctgagaacc agctccatgg tggcgaggct      480

atcattacaa ggacagtgcg acgaacaccc ccaggtgcat ttgatcctac tatcaaaaat      540

ctacagtggg gtgatttaat taagggaatg tttgaggcaa tggaccgtgg cgccacatac      600

ccatttctca ctgatggaga caccaacctt actgaaggat gcggtttcaa cattgttttg      660

gtgaagaacg gtattatcta tacccctgat cgaggtgtct tgcgagggat cacacgtaaa      720

agtgtgattg acgttgcccg agccaacagc atcgacatcc gccttgaggt cgtaccagtg      780

gagcaggctt atcactctga tgagatcttc atgtgcacaa ctgccggcgg cattatgcct      840

ataacattgc ttgatggtca acctgttaat gacggccagg ttggcccaat cacaaagaag      900

atatgggatg gctattggga gatgcactac aatccggcgt atagttttcc tgttgactat      960

ggcagtggc                                                              969


<210>  34
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  34

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Val Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Trp Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Cys Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Arg Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Thr Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  35
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  35
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatggcca gcgacctgac ctacgacacg      180

atccgcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc      360

ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcat caaaggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  36
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  36

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Ala Ser Asp Leu Thr Tyr Asp Thr Ile Arg Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  37
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  37
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg      180

ttcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc      360

ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  38
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  38

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Phe Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  39
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  39
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgcgca gcgacctgac ctacgacacg      180

atccacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc      360

ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  40
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  40

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Arg Ser Asp Leu Thr Tyr Asp Thr Ile His Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Asn Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  41
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  41
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgggca gcgacctgac ctacgacacg      180

ttcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc      360

ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcaa caaaggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  42
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  42

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Gly Ser Asp Leu Thr Tyr Asp Thr Phe Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  43
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  43
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgaaca gcgacctgac ctacgacacg      180

atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc      360

ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcat ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  44
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  44

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Asn Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  45
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  45
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg      180

ttccacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc      360

ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctcaa caaaggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  46
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  46

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Phe His Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Asn Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  47
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  47
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg      180

atccacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc      360

ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcat ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  48
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  48

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Ile His Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  49
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  49
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgcgca gcgacctgac ctacgacacg      180

atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcgaggtcat tgttacccgc      360

ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcaa caaaggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  50
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  50

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Arg Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  51
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  51
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg      180

atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcgagatcat tgttacccgc      360

ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcat caaaggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  52
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  52

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  53
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  53
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg      180

ttcaacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc      360

ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  54
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  54

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Phe Asn Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  55
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  55
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgggca gcgacctgac ctacgacacg      180

atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc      360

ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcat caaaggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  56
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  56

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Gly Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  57
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  57
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgagca gcgacctgac ctacgacacg      180

atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg gcaaggtcat tgttacccgc      360

ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  58
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  58

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Ser Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Gly Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  59
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  59
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacctgac ctacgacacg      180

atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc      360

ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  60
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  60

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  61
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  61
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgggca gcgacctgac ctacgacacg      180

atccacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcgagatcat tgttacccgc      360

ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcaa caaaggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  62
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  62

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Gly Ser Asp Leu Thr Tyr Asp Thr Ile His Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  63
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  63
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatggcca gcgacctgac ctacgacacg      180

atccacgttt gggacggtcg ctttttccgt ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg gcaagatcat tgttacccgc      360

ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  64
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  64

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Ala Ser Asp Leu Thr Tyr Asp Thr Ile His Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Gly Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Asn Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  65
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  65
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacctgac ctacgacacg      180

ttcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc      360

ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  66
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  66

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Phe Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Asn Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  67
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  67
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg      180

atccacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc      360

ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  68
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  68

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Ile His Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Asn Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  69
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  69
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatggcca gcgacctgac ctacgacacg      180

atcaacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaaggtcat tgttacccgc      360

ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcat caaaggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  70
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  70

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Ala Ser Asp Leu Thr Tyr Asp Thr Ile Asn Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  71
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  71
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgaaca gcgacctgac ctacgacacg      180

atcaacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc      360

ggtctgacag gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcat ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  72
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  72

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Asn Ser Asp Leu Thr Tyr Asp Thr Ile Asn Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  73
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  73
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacctgac ctacgacacg      180

atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc      360

ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcat ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  74
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  74

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  75
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  75
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg      180

ttcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc      360

ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctcat ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  76
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  76

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Phe Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  77
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  77
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgagca gcgacctgac ctacgacacg      180

ttccacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc      360

ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctcat ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  78
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  78

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Ser Ser Asp Leu Thr Tyr Asp Thr Phe His Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  79
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  79
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgaaca gcgacctgac ctacgacacg      180

atcaacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc      360

ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatttcat caaaggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  80
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  80

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Asn Ser Asp Leu Thr Tyr Asp Thr Ile Asn Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Phe Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  81
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  81
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgacca gcgacctgac ctacgacacg      180

atccacgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcgaggtcat tgttacccgc      360

ggtctgaccg gcgttcaggg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctcaa ccgtggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  82
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  82

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Thr Ser Asp Leu Thr Tyr Asp Thr Ile His Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Gln Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Asn Arg Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  83
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  83
atggcaacca tagataaagt ctttgcgggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gcaaatttgt cctgccgtac      120

gaagcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacctgac ctacgacacg      180

atcagcgttt gggacggtcg ctttttccgc ctggacgatc atctgcaacg tatcctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gttgaaatgg ttgcaaaaag cggtattcgc gacgcgatgg tcaagatcat tgttacccgc      360

ggtctgaccg gcgttcgtgg tcgcaaaccg gaggacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagacc aaagccacgg cggttctgcg      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctcaa caaaggtatg tttgaagcga aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttt atgtgttcga ccggcggcgg tattatgccg      840

atcaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  84
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  84

Met Ala Thr Ile Asp Lys Val Phe Ala Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Tyr Glu Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Leu Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Val Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Lys Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ser His Gly Gly Ser Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Asn Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Gly Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  85
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  85
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttaatgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  86
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  86

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Asn Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  87
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  87
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttgatgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  88
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  88

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Asp Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  89
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  89
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcaa gagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  90
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  90

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Lys Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  91
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  91
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgctc tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  92
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  92

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Ser Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  93
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  93
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgccc gagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  94
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  94

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Pro Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  95
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  95
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

caggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  96
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  96

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Gln Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  97
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  97
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

acggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  98
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  98

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Thr Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  99
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  99
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggtttcgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  100
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  100

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Ser Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  101
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  101
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttcggc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  102
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  102

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Arg Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  103
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  103
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggcag gtttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  104
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  104

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  105
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  105
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttgt tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  106
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  106

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Val Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  107
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  107
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tttatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  108
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  108

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Tyr Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  109
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  109
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgttta gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  110
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  110

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Phe Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  111
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  111
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgttga gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  112
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  112

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Leu Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  113
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  113
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacagtacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  114
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  114

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Ser Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  115
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  115
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  116
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  116

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  117
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  117
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  118
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  118

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  119
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  119
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attgcggttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  120
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  120

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ala Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  121
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  121
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tccatgttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  122
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  122

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val His Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  123
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  123
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tctatgttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca cctgaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  124
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  124

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Tyr Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  125
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  125
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tctttgttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  126
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  126

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Phe Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  127
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  127
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtgat      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  128
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  128

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Asp 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  129
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  129
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgtgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtagt      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  130
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  130

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Cys Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Ser 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  131
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  131
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtcag      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  132
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  132

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Gln 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  133
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  133
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacgacacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ctgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  134
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  134

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Asp Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Ser Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  135
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  135
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgag gaaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  136
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  136

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Arg Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  137
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  137
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcat tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  138
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  138

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Leu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  139
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  139
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  140
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  140

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  141
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  141
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcaa ttgatccgac gattaaaaac      540

taccaatggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  142
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  142

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Ile Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Tyr Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  143
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  143
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  144
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  144

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  145
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  145
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcac gtgatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  146
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  146

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Arg Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  147
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  147
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  148
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  148

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  149
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  149
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attccgattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  150
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  150

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Pro Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  151
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  151
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  152
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  152

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  153
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  153
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggaa tatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  154
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  154

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Asn Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  155
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  155
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  156
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  156

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  157
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  157
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

catgaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  158
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  158

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu His Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  159
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  159
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgtctg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  160
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  160

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Ser Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  161
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  161
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg taataaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  162
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  162

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  163
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  163
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgttggg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  164
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  164

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu Leu Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  165
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  165
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgattgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  166
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  166

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu Ile Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  167
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  167
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  168
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  168

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  169
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  169
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagctgcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  170
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  170

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  171
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  171
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaatttgcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  172
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  172

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Phe Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  173
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  173
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacgctga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  174
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  174

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  175
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  175
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  176
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  176

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  177
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  177
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgcaaccag gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatcccgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  178
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  178

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Asn Gln Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  179
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  179
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaagag gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgcagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  180
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  180

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Glu Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  181
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  181
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaacag gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgcagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  182
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  182

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Gln Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  183
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  183
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagcaaacag gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  184
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  184

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Gln Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  185
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  185
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgcaaccag gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgcagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatgccgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  186
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  186

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Asn Gln Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  187
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  187
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaagag gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgcagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  188
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  188

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Glu Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  189
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  189
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagccaagcg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  190
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  190

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Gln Ala Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  191
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  191
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  192
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  192

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  193
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  193
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  194
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  194

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  195
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  195
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggagcgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgactgggg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aaatccacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc tgttgtagca ccgctggcgg tattatgccg      840

atcaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

attatggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  196
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  196

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Asp Trp Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Ile His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Cys Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  197
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  197
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctgacgcgc       60

tctgataacc cttttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgacca gcaacagggg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgccacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc tgttgtagca ccgctggcgg tattatgccg      840

gtcaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

attatggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  198
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  198

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Thr Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Asn Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Cys Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Val Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  199
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  199
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggagcgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgtctgggg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgccacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

atcaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  200
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  200

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Trp Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  201
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  201
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggcgcgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgacca gcgtctgggg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactccacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

atcaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

attatggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  202
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  202

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Ala Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Val Trp Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  203
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  203
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg gtggaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  204
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  204

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Val Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  205
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  205
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgatgtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  206
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  206

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Met Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  207
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  207
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gcatgaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  208
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  208

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu His Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  209
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  209
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gattgaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  210
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  210

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Ile Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  211
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  211
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tgggttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  212
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  212

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Trp Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  213
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  213
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtacgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  214
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  214

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Thr Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  215
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  215
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  216
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  216

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  217
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  217
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggaa catgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  218
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  218

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Asn Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  219
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  219
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggaa catgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  220
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  220

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Asn Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  221
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  221
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggaa catgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  222
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  222

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Asn Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  223
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  223
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  224
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  224

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  225
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  225
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  226
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  226

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  227
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  227
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  228
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  228

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  229
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  229
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggaa catgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  230
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  230

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Asn Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  231
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  231
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  232
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  232

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  233
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  233
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  234
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  234

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  235
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  235
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  236
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  236

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  237
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  237
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  238
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  238

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  239
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  239
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  240
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  240

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  241
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  241
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  242
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  242

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  243
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  243
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc      360

ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  244
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  244

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  245
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  245
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  246
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  246

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  247
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  247
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggaa catgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  248
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  248

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Asn Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  249
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  249
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  250
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  250

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  251
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  251
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  252
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  252

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  253
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  253
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc      360

ggtctgaccg gcgttcgcgg taacaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga aatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  254
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  254

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Asn 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  255
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  255
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacgcgga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  256
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  256

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  257
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  257
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attgcggttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

catgaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tccatgttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacgcgga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  258
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  258

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ala Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu His Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val His Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  259
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  259
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attgcggttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

catgaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  260
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  260

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ala Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu His Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  261
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  261
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attgcggttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacgcgga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  262
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  262

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ala Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ala Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  263
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  263
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgtcgg gcgttggcgg tagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  264
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  264

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Ser Gly Val Gly Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  265
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  265
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgtcgg gcgttggcaa gagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  266
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  266

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Ser Gly Val Gly Lys Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  267
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  267
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgacgg gcgttgacaa gagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  268
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  268

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Asp Lys Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  269
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  269
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgtcgg gcgttggcaa gaacaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  270
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  270

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Ser Gly Val Gly Lys Asn 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  271
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  271
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgtcgg gcgttcacgg tagcaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  272
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  272

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Ser Gly Val His Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  273
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  273
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaagaac      540

ttcatgtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  274
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  274

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Met Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  275
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  275
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gcttatggca ccggaaaagc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  276
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  276

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Lys Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  277
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  277
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcatactg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat cactcgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  278
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  278

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Ile Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  279
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  279
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcttactg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat cactcgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  280
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  280

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Leu Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  281
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  281
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaaaatc aactgagggg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  282
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  282

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asn Gln Leu Arg Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  283
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  283
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgacg      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  284
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  284

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Thr Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  285
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  285
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgtttttg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  286
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  286

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Phe Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  287
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  287
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tgtgatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  288
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  288

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Val Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  289
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  289
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attgtgaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  290
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  290

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Val Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  291
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  291
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcctgta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  292
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  292

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  293
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  293
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgacca gcaatcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg actgaaggtc cgggttttaa cattgtcctg      660

gtcaaaaacg gcatcctgta taccccggat cgtggcgttc tggaaggtat tacccgcaaa      720

agcgttattg aagttgcgcg cgcaaattcc attgatgtcc gcctggaagt tgttccggtt      780

gaaaccgcat accacgcgga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

gtgaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  294
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  294

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Asn Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Pro Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Leu Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Glu Val Ala Arg Ala Asn Ser Ile Asp Val Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Thr Ala Tyr His Ala Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Val Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  295
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  295
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgacca gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  296
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  296

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  297
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  297
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

attatggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  298
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  298

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  299
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  299
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgatca gcaatcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  300
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  300

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Ile Ser Asn Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  301
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  301
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

gtgaccctgc tggacggtca accggttaac gacggtcagg taggcccgat taccaaaaag      900

attatggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  302
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  302

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Val Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  303
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  303
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgacca gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

attatggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  304
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  304

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  305
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  305
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgacca gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat tacaaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  306
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  306

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  307
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  307
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  308
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  308

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  309
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  309
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcaatcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  310
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  310

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Asn Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  311
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  311
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgcc ggacgaagcc tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaacatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tagtaaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat ttgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga taccaatctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgtgtagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aatccggcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  312
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  312

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Pro Asp 
        35                  40                  45              


Glu Ala Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Asn Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Ser 
        115                 120                 125             


Lys Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


Asn Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Cys 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Pro Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  313
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  313
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

attatggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  314
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  314

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  315
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  315
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgacca gcaatcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

attatggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  316
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  316

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Asn Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  317
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  317
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgacca gcaatcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  318
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  318

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Asn Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  319
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  319
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgacca gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattat aacgcggcgt acagctttcc ggtagattat      960

ggtagcgat                                                              969


<210>  320
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  320

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Ala Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Asp 
            


<210>  321
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  321
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcaatcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  322
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  322

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Asn Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  323
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  323
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc      360

ggtctgacaa gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggaa tatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  324
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  324

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Asn Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  325
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  325
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgacca gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  326
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  326

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Ser Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  327
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  327
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgacca gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

gtgaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  328
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  328

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Ser Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Val Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  329
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  329
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcaatcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  330
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  330

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Asn Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  331
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  331
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggaa tatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  332
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  332

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Asn Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  333
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  333
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc      360

ggtctgacca gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  334
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  334

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  335
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  335
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgacca gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggaa tatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  336
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  336

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Ser Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Asn Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  337
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  337
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcaatcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

attatggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  338
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  338

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Asn Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Met Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  339
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  339
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcaatcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  340
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  340

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Asn Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  341
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  341
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgacca gcaatcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc tgcaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtaa accggttaac gacggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  342
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  342

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Ser Asn Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Cys Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Lys Pro 
        275                 280                 285             


Val Asn Asp Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  343
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  343
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tattctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagttat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  344
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  344

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Ile Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  345
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  345
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggaa tatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  346
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  346

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Asn Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  347
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  347
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcaatcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aactgcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

ctgcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  348
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  348

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Asn Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Leu His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Leu Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  349
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  349
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaagtgat tgttacccgc      360

ggtctgacca gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaacaggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggaa tatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  350
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  350

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Val Ile Val Thr Arg Gly Leu Thr Ser Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Gln Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Asn Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  351
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  351
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  352
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  352

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  353
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  353
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaactggt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgacca gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aagatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggaa tatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  354
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  354

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Leu Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Ser Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Asn Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  355
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  355
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcctg ttcgaagcag aggatcgcgg cgcaaagtat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  356
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  356

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Leu Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Lys Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  357
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  357
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcacagtat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  358
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  358

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Gln Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  359
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  359
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcaa aggatcgcgg cgcagagtat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  360
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  360

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Glu Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  361
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  361
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcctg ttcgaagcaa aggatcgcgg cgcagagtat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  362
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  362

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Leu Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Glu Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  363
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  363
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcaa acgatcgcgg cgcagagtat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  364
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  364

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Asn Asp Arg Gly Ala Glu Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  365
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  365
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcaa aggatcgcgg cgcaaagtat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  366
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  366

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Lys Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  367
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  367
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag tggatcgcgg cgcacagtat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  368
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  368

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Val Asp Arg Gly Ala Gln Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  369
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  369
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag aggatcgcgg cgcaacgtat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  370
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  370

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Glu Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  371
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  371
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag tggatcgcgg cgcagagtat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  372
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  372

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Val Asp Arg Gly Ala Glu Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  373
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  373
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag acgatcgcgg cgcacagtat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  374
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  374

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Asp Asp Arg Gly Ala Gln Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  375
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  375
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag tggatcgcgg cgcaaagtat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  376
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  376

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Val Asp Arg Gly Ala Lys Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  377
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  377
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcaa aggatcgcgg cgcaacgtat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  378
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  378

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Lys Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  379
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  379
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcaa tcgatcgcgg cgcaaagtat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  380
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  380

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Ile Asp Arg Gly Ala Lys Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  381
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  381
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcctg ttcgaagcag acgatcgcgg cgcacagtat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  382
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  382

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Leu Phe Glu 
            180                 185                 190         


Ala Asp Asp Arg Gly Ala Gln Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  383
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  383
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcgca gcgacgtgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgattttac caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  384
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  384

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Arg Ser Asp Val Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Phe Thr Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  385
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  385
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcgca gcgactcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatttgac caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  386
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  386

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Arg Ser Asp Ser Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Thr Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  387
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  387
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcgca gcgacgtgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatttgac caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  388
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  388

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met Arg Ser Asp Val Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Thr Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  389
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  389
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcacg cggacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  390
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  390

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ala Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  391
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  391
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcag gtgatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  392
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  392

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Gly Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  393
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  393
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgcat tcggtccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  394
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  394

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Ala Phe Gly Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  395
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  395
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttcgcgg tcgccaaccg gaagacctgt acaacaacaa catctacctg      420

ctggttctgc cgtatatctg gctgatggca ccggaagatc aacgtcacgg cggcgaagca      480

attattaccc gtaccgttcg tcgtaccccg ccgggcgatt tcgatccgac cattaaaaac      540

tttcagtggg gcgatctgat caaaggcatg ttcgaagcaa tggatcgcgg cgcaacctat      600

ccgtttctga ccgacggcga tacccacctg accgaaggta gcggttttaa catcgtcctg      660

gtcaaaaacg gcatcatcta caccccggat cgcggcgttc tggaaggtat tacccgtaaa      720

agcgttattg acgttgcacg cgcaaacagt attgatattc gcctggaagt cgtcccggtt      780

gaagcggcgt atcacagcga cgaaatcttc atgaccagca ccgctggcgg tattatgccg      840

attaccctgc tggacggtca accggttaac ggcggtcagg taggcccgat taccaaaaag      900

atttgggacg gctactggga gatgcattac aataacgcgt atagctttcc ggtcgattac      960

ggtagcggt                                                              969


<210>  396
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  396

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Arg Gly Arg 
        115                 120                 125             


Gln Pro Glu Asp Leu Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro 
    130                 135                 140                 


Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala 
145                 150                 155                 160 


Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro Gly Asp Phe Asp Pro 
                165                 170                 175     


Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu 
            180                 185                 190         


Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr 
        195                 200                 205             


His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly 
    210                 215                 220                 


Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys 
225                 230                 235                 240 


Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu 
                245                 250                 255     


Val Val Pro Val Glu Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr 
            260                 265                 270         


Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro 
        275                 280                 285             


Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly 
    290                 295                 300                 


Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr 
305                 310                 315                 320 


Gly Ser Gly 
            


<210>  397
<211>  954
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  397
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtctgaccg gcgttagcgg ctcttacaac aacaacatct acctgctggt tctgccgtat      420

atctggctga tggcaccgga agatcaacgt cacggcggcg aagcaattat tacccgtacc      480

gttcgtcgta ccccgccggg cgcattcgat ccgaccatta aaaactttca gtggggcgat      540

ctgatcaaag gcatgttcga agcaatggat cgcggcgcaa cctatccgtt tctgaccgac      600

ggcgataccc acctgaccga aggtagcggt tttaacatcg tcctggtcaa aaacggcatc      660

atctacaccc cggatcgcgg cgttctggaa ggtattaccc gtaaaagcgt tattgacgtt      720

gcacgcgcaa acagtattga tattcgcctg gaagtcgtcc cggttgaagc ggcgtatcac      780

agcgacgaaa tcttcatgac cagcaccgct ggcggtatta tgccgattac cctgctggac      840

ggtcaaccgg ttaacggcgg tcaggtaggc ccgattacca aaaagatttg ggacggctac      900

tgggagatgc attacaataa cgcgtatagc tttccggtcg attacggtag cggt            954


<210>  398
<211>  318
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  398

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Leu Thr Gly Val Ser Gly Ser 
        115                 120                 125             


Tyr Asn Asn Asn Ile Tyr Leu Leu Val Leu Pro Tyr Ile Trp Leu Met 
    130                 135                 140                 


Ala Pro Glu Asp Gln Arg His Gly Gly Glu Ala Ile Ile Thr Arg Thr 
145                 150                 155                 160 


Val Arg Arg Thr Pro Pro Gly Ala Phe Asp Pro Thr Ile Lys Asn Phe 
                165                 170                 175     


Gln Trp Gly Asp Leu Ile Lys Gly Met Phe Glu Ala Met Asp Arg Gly 
            180                 185                 190         


Ala Thr Tyr Pro Phe Leu Thr Asp Gly Asp Thr His Leu Thr Glu Gly 
        195                 200                 205             


Ser Gly Phe Asn Ile Val Leu Val Lys Asn Gly Ile Ile Tyr Thr Pro 
    210                 215                 220                 


Asp Arg Gly Val Leu Glu Gly Ile Thr Arg Lys Ser Val Ile Asp Val 
225                 230                 235                 240 


Ala Arg Ala Asn Ser Ile Asp Ile Arg Leu Glu Val Val Pro Val Glu 
                245                 250                 255     


Ala Ala Tyr His Ser Asp Glu Ile Phe Met Thr Ser Thr Ala Gly Gly 
            260                 265                 270         


Ile Met Pro Ile Thr Leu Leu Asp Gly Gln Pro Val Asn Gly Gly Gln 
        275                 280                 285             


Val Gly Pro Ile Thr Lys Lys Ile Trp Asp Gly Tyr Trp Glu Met His 
    290                 295                 300                 


Tyr Asn Asn Ala Tyr Ser Phe Pro Val Asp Tyr Gly Ser Gly 
305                 310                 315             


<210>  399
<211>  936
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  399
atggcaagca tggataaagt cttcagcggc tattacgcgc gtcaaaaact gctggaacgc       60

tctgataacc cgtttagcaa aggcatcgcg tacgttgaag gtaaatttgt tctgccgagc      120

gacgcacgta ttccgctgct ggacgaaggt tttatgcaca gcgacgcgac ctacactacc      180

attagcgttt gggacggccg ctttttccgt ctggacgatc atctgcagcg tctgctggaa      240

tcctgcgaca aaatgcgcct gaaatttccg ctggcactga gcagcgttaa aaaaatcctg      300

gcggaaatgg ttgcgaaatc tggtattcgc gatgcgatgg tcgaaattat tgttacccgc      360

ggtagcggct ctaacaacat ctacctgctg gttctgccgt atatctggct gatggcaccg      420

gaagatcaac gtcacggcgg cgaagcaatt attacccgta ccgttcgtcg taccccgccg      480

ggcgcattcg atccgaccat taaaaacttt cagtggggcg atctgatcaa aggcatgttc      540

gaagcaatgg atcgcggcgc aacctatccg tttctgaccg acggcgatac ccacctgacc      600

gaaggtagcg gttttaacat cgtcctggtc aaaaacggca tcatctacac cccggatcgc      660

ggcgttctgg aaggtattac ccgtaaaagc gttattgacg ttgcacgcgc aaacagtatt      720

gatattcgcc tggaagtcgt cccggttgaa gcggcgtatc acagcgacga aatcttcatg      780

accagcaccg ctggcggtat tatgccgatt accctgctgg acggtcaacc ggttaacggc      840

ggtcaggtag gcccgattac caaaaagatt tgggacggct actgggagat gcattacaat      900

aacgcgtata gctttccggt cgattacggt agcggt                                936


<210>  400
<211>  312
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Engineered sequence

<400>  400

Met Ala Ser Met Asp Lys Val Phe Ser Gly Tyr Tyr Ala Arg Gln Lys 
1               5                   10                  15      


Leu Leu Glu Arg Ser Asp Asn Pro Phe Ser Lys Gly Ile Ala Tyr Val 
            20                  25                  30          


Glu Gly Lys Phe Val Leu Pro Ser Asp Ala Arg Ile Pro Leu Leu Asp 
        35                  40                  45              


Glu Gly Phe Met His Ser Asp Ala Thr Tyr Thr Thr Ile Ser Val Trp 
    50                  55                  60                  


Asp Gly Arg Phe Phe Arg Leu Asp Asp His Leu Gln Arg Leu Leu Glu 
65                  70                  75                  80  


Ser Cys Asp Lys Met Arg Leu Lys Phe Pro Leu Ala Leu Ser Ser Val 
                85                  90                  95      


Lys Lys Ile Leu Ala Glu Met Val Ala Lys Ser Gly Ile Arg Asp Ala 
            100                 105                 110         


Met Val Glu Ile Ile Val Thr Arg Gly Ser Gly Ser Asn Asn Ile Tyr 
        115                 120                 125             


Leu Leu Val Leu Pro Tyr Ile Trp Leu Met Ala Pro Glu Asp Gln Arg 
    130                 135                 140                 


His Gly Gly Glu Ala Ile Ile Thr Arg Thr Val Arg Arg Thr Pro Pro 
145                 150                 155                 160 


Gly Ala Phe Asp Pro Thr Ile Lys Asn Phe Gln Trp Gly Asp Leu Ile 
                165                 170                 175     


Lys Gly Met Phe Glu Ala Met Asp Arg Gly Ala Thr Tyr Pro Phe Leu 
            180                 185                 190         


Thr Asp Gly Asp Thr His Leu Thr Glu Gly Ser Gly Phe Asn Ile Val 
        195                 200                 205             


Leu Val Lys Asn Gly Ile Ile Tyr Thr Pro Asp Arg Gly Val Leu Glu 
    210                 215                 220                 


Gly Ile Thr Arg Lys Ser Val Ile Asp Val Ala Arg Ala Asn Ser Ile 
225                 230                 235                 240 


Asp Ile Arg Leu Glu Val Val Pro Val Glu Ala Ala Tyr His Ser Asp 
                245                 250                 255     


Glu Ile Phe Met Thr Ser Thr Ala Gly Gly Ile Met Pro Ile Thr Leu 
            260                 265                 270         


Leu Asp Gly Gln Pro Val Asn Gly Gly Gln Val Gly Pro Ile Thr Lys 
        275                 280                 285             


Lys Ile Trp Asp Gly Tyr Trp Glu Met His Tyr Asn Asn Ala Tyr Ser 
    290                 295                 300                 


Phe Pro Val Asp Tyr Gly Ser Gly 
305                 310         


