                         SEQUENCE LISTING

<110>  ϺϸоԺ
       ϺϸƼ޹˾
 
<120>  һCD40˫򼤻̼弰;

<130>  IEC180213PCT

<150>  201711466912.8
<151>  2017-12-28

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8źĵİ

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser 
            20          


<210>  2
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD40⼤͵İ

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Thr Ala 
            180                 185                 190         


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  3
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4Fc CH2CH3İ

<400>  3

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  4
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28Ĥİ

<400>  4

Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25              


<210>  5
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28ڹ̼źŰڽṹİ

<400>  5

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  6
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD137ڹ̼źŰڽṹİ

<400>  6

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  7
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40DCR1İУźģ

<400>  7

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Asn Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr 
        115                 120                 125             


Asn Gly Val Cys Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
            180                 185                 190         


Tyr Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn 
        195                 200                 205             


Leu Leu Ile Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile 
                245                 250                 255     


Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser 
            260                 265                 270         


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
305                 310                 315                 320 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Leu Gly Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            500                 505                 510         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
        515                 520                 525             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    530                 535                 540                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
545                 550                 555                 560 


Arg Asp Phe Ala Ala Tyr Arg Ser 
                565             


<210>  8
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   40DCR2İУźģ

<400>  8

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Asn Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr 
        115                 120                 125             


Asn Gly Val Cys Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
            180                 185                 190         


Tyr Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn 
        195                 200                 205             


Leu Leu Ile Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile 
                245                 250                 255     


Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser 
            260                 265                 270         


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
305                 310                 315                 320 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Leu Gly Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            500                 505                 510         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
        515                 520                 525             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    530                 535                 540                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
545                 550                 555                 560 


Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                565                 


<210>  9
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40DCR3İУźģ

<400>  9

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Asn Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr 
        115                 120                 125             


Asn Gly Val Cys Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
            180                 185                 190         


Tyr Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn 
        195                 200                 205             


Leu Leu Ile Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile 
                245                 250                 255     


Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser 
            260                 265                 270         


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
305                 310                 315                 320 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Leu Gly Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            500                 505                 510         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
        515                 520                 525             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    530                 535                 540                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
545                 550                 555                 560 


Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu 
                565                 570                 575     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            580                 585                 590         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        595                 600                 605             


Glu Leu 
    610 


<210>  10
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40DCR4İУźģ

<400>  10

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Gly Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Asn Arg Leu Arg Ser Asp Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr 
        115                 120                 125             


Asn Gly Val Cys Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
            180                 185                 190         


Tyr Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn 
        195                 200                 205             


Leu Leu Ile Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile 
                245                 250                 255     


Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser 
            260                 265                 270         


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
305                 310                 315                 320 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Leu Gly Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            500                 505                 510         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
        515                 520                 525             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    530                 535                 540                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
545                 550                 555                 560 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Ser Lys Arg Ser Arg Leu 
                565                 570                 575     


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
            580                 585                 590         


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
        595                 600                 605             


Arg Ser 
    610 


<210>  11
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40DCR1İУźģ

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Thr Ala 
            180                 185                 190         


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Phe Trp 
465                 470                 475                 480 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                485                 490                 495     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
            500                 505                 510         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        515                 520                 525             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    530                 535                 540                 


Arg Ser 
545     


<210>  12
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40DCR2İУźģ

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Thr Ala 
            180                 185                 190         


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Phe Trp 
465                 470                 475                 480 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                485                 490                 495     


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
            500                 505                 510         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        515                 520                 525             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    530                 535                 540                 


Cys Glu Leu 
545         


<210>  13
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40DCR3İУźģ

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Thr Ala 
            180                 185                 190         


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Phe Trp 
465                 470                 475                 480 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                485                 490                 495     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
            500                 505                 510         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        515                 520                 525             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    530                 535                 540                 


Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
545                 550                 555                 560 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                565                 570                 575     


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            580                 585             


<210>  14
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40DCR4İУźģ

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Thr Ala 
            180                 185                 190         


Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Pro Phe Trp 
465                 470                 475                 480 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                485                 490                 495     


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
            500                 505                 510         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        515                 520                 525             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    530                 535                 540                 


Cys Glu Leu Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
545                 550                 555                 560 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
                565                 570                 575     


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            580                 585             


<210>  15
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40DCR1ĺУźģ

<400>  15
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagccagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccggct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggatggatca accctgacag tggtggcaca      240

aactatgcac agaagtttca gggcagggtc accatgacca gggacacgtc catcagcaca      300

gcctacatgg agctgaacag gctgagatct gacgacacgg ccgtgtatta ctgtgcgaga      360

gatcagcccc taggatattg tactaatggt gtatgctcct actttgacta ctggggccag      420

ggaaccctgg tcaccgtctc ctcaggtgga ggcggttcag gcggaggtgg cagcggcggt      480

ggcgggtcgg acatccagat gacccagtct ccatcttccg tgtctgcatc tgtaggagac      540

agagtcacca tcacttgtcg ggcgagtcag ggtatttaca gctggttagc ctggtatcag      600

cagaaaccag ggaaagcccc taacctcctg atctatactg catccacttt acaaagtggg      660

gtcccatcaa ggttcagcgg cagtggatct gggacagatt tcactctcac catcagcagc      720

ctgcaacctg aagattttgc aacttactat tgtcaacagg ctaacatttt cccgctcact      780

ttcggcggag ggaccaaggt ggagatcaaa gagtccaaat atggtccccc atgcccacca      840

tgcccagcac ctgagttcct ggggggacca tcagtcttcc tgttcccccc aaaacccaag      900

gacactctca tgatctcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccag      960

gaagaccccg aggtccagtt caactggtac gtggatggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gttcaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtctccaa caaaggcctc     1140

ccgtcctcca tcgagaaaac catctccaaa gccaaagggc agccccgaga gccacaggtg     1200

tacaccctgc ccccatccca ggaggagatg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctaccccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aggctaaccg tggacaagag caggtggcag gaggggaatg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacacag aagagcctct ccctgtctct gggtaaaccc     1500

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg     1560

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg     1620

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca     1680

cgcgacttcg cagcctatcg ctcc                                            1704


<210>  16
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40DCR2ĺУźģ

<400>  16
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagccagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccggct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggatggatca accctgacag tggtggcaca      240

aactatgcac agaagtttca gggcagggtc accatgacca gggacacgtc catcagcaca      300

gcctacatgg agctgaacag gctgagatct gacgacacgg ccgtgtatta ctgtgcgaga      360

gatcagcccc taggatattg tactaatggt gtatgctcct actttgacta ctggggccag      420

ggaaccctgg tcaccgtctc ctcaggtgga ggcggttcag gcggaggtgg cagcggcggt      480

ggcgggtcgg acatccagat gacccagtct ccatcttccg tgtctgcatc tgtaggagac      540

agagtcacca tcacttgtcg ggcgagtcag ggtatttaca gctggttagc ctggtatcag      600

cagaaaccag ggaaagcccc taacctcctg atctatactg catccacttt acaaagtggg      660

gtcccatcaa ggttcagcgg cagtggatct gggacagatt tcactctcac catcagcagc      720

ctgcaacctg aagattttgc aacttactat tgtcaacagg ctaacatttt cccgctcact      780

ttcggcggag ggaccaaggt ggagatcaaa gagtccaaat atggtccccc atgcccacca      840

tgcccagcac ctgagttcct ggggggacca tcagtcttcc tgttcccccc aaaacccaag      900

gacactctca tgatctcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccag      960

gaagaccccg aggtccagtt caactggtac gtggatggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gttcaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtctccaa caaaggcctc     1140

ccgtcctcca tcgagaaaac catctccaaa gccaaagggc agccccgaga gccacaggtg     1200

tacaccctgc ccccatccca ggaggagatg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctaccccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aggctaaccg tggacaagag caggtggcag gaggggaatg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacacag aagagcctct ccctgtctct gggtaaaccc     1500

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg     1560

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg     1620

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca     1680

cgcgacttcg cagcctatcg ctcc                                            1704


<210>  17
<211>  1830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40DCR3ĺУźģ

<400>  17
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagccagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccggct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggatggatca accctgacag tggtggcaca      240

aactatgcac agaagtttca gggcagggtc accatgacca gggacacgtc catcagcaca      300

gcctacatgg agctgaacag gctgagatct gacgacacgg ccgtgtatta ctgtgcgaga      360

gatcagcccc taggatattg tactaatggt gtatgctcct actttgacta ctggggccag      420

ggaaccctgg tcaccgtctc ctcaggtgga ggcggttcag gcggaggtgg cagcggcggt      480

ggcgggtcgg acatccagat gacccagtct ccatcttccg tgtctgcatc tgtaggagac      540

agagtcacca tcacttgtcg ggcgagtcag ggtatttaca gctggttagc ctggtatcag      600

cagaaaccag ggaaagcccc taacctcctg atctatactg catccacttt acaaagtggg      660

gtcccatcaa ggttcagcgg cagtggatct gggacagatt tcactctcac catcagcagc      720

ctgcaacctg aagattttgc aacttactat tgtcaacagg ctaacatttt cccgctcact      780

ttcggcggag ggaccaaggt ggagatcaaa gagtccaaat atggtccccc atgcccacca      840

tgcccagcac ctgagttcct ggggggacca tcagtcttcc tgttcccccc aaaacccaag      900

gacactctca tgatctcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccag      960

gaagaccccg aggtccagtt caactggtac gtggatggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gttcaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtctccaa caaaggcctc     1140

ccgtcctcca tcgagaaaac catctccaaa gccaaagggc agccccgaga gccacaggtg     1200

tacaccctgc ccccatccca ggaggagatg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctaccccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aggctaaccg tggacaagag caggtggcag gaggggaatg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacacag aagagcctct ccctgtctct gggtaaaccc     1500

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg     1560

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg     1620

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca     1680

cgcgacttcg cagcctatcg ctccaaacgg ggcagaaaga agctcctgta tatattcaaa     1740

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt     1800

ccagaagaag aagaaggagg atgtgaactg                                      1830


<210>  18
<211>  1830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40DCR4ĺУźģ

<400>  18
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagccagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacacc ttcaccggct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggatggatca accctgacag tggtggcaca      240

aactatgcac agaagtttca gggcagggtc accatgacca gggacacgtc catcagcaca      300

gcctacatgg agctgaacag gctgagatct gacgacacgg ccgtgtatta ctgtgcgaga      360

gatcagcccc taggatattg tactaatggt gtatgctcct actttgacta ctggggccag      420

ggaaccctgg tcaccgtctc ctcaggtgga ggcggttcag gcggaggtgg cagcggcggt      480

ggcgggtcgg acatccagat gacccagtct ccatcttccg tgtctgcatc tgtaggagac      540

agagtcacca tcacttgtcg ggcgagtcag ggtatttaca gctggttagc ctggtatcag      600

cagaaaccag ggaaagcccc taacctcctg atctatactg catccacttt acaaagtggg      660

gtcccatcaa ggttcagcgg cagtggatct gggacagatt tcactctcac catcagcagc      720

ctgcaacctg aagattttgc aacttactat tgtcaacagg ctaacatttt cccgctcact      780

ttcggcggag ggaccaaggt ggagatcaaa gagtccaaat atggtccccc atgcccacca      840

tgcccagcac ctgagttcct ggggggacca tcagtcttcc tgttcccccc aaaacccaag      900

gacactctca tgatctcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccag      960

gaagaccccg aggtccagtt caactggtac gtggatggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gttcaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtctccaa caaaggcctc     1140

ccgtcctcca tcgagaaaac catctccaaa gccaaagggc agccccgaga gccacaggtg     1200

tacaccctgc ccccatccca ggaggagatg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctaccccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aggctaaccg tggacaagag caggtggcag gaggggaatg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacacag aagagcctct ccctgtctct gggtaaaccc     1500

ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg     1560

gcctttatta ttttctgggt gaaacggggc agaaagaagc tcctgtatat attcaaacaa     1620

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1680

gaagaagaag aaggaggatg tgaactgagg agtaagagga gcaggctcct gcacagtgac     1740

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc     1800

ccaccacgcg acttcgcagc ctatcgctcc                                      1830


<210>  19
<211>  1638
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40DCR1ĺУźģ

<400>  19
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaaccctg acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga acaggctgag atctgacgac acggccgtgt attactgtgc gagagatcag      300

cccctaggat attgtactaa tggtgtatgc tcctactttg actactgggg ccagggaacc      360

ctggtcaccg tctcctcagg tggaggcggt tcaggcggag gtggcagcgg cggtggcggg      420

tcggacatcc agatgaccca gtctccatct tccgtgtctg catctgtagg agacagagtc      480

accatcactt gtcgggcgag tcagggtatt tacagctggt tagcctggta tcagcagaaa      540

ccagggaaag cccctaacct cctgatctat actgcatcca ctttacaaag tggggtccca      600

tcaaggttca gcggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcaa      660

cctgaagatt ttgcaactta ctattgtcaa caggctaaca ttttcccgct cactttcggc      720

ggagggacca aggtggagat caaagagtcc aaatatggtc ccccatgccc accatgccca      780

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact      840

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      900

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc     1080

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc     1140

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1200

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1320

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggtaa acccttttgg     1440

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttt     1500

attattttct gggtgaggag taagaggagc aggctcctgc acagtgacta catgaacatg     1560

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac     1620

ttcgcagcct atcgctcc                                                   1638


<210>  20
<211>  1638
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  28DCR2ĺУźģ

<400>  20
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaaccctg acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga acaggctgag atctgacgac acggccgtgt attactgtgc gagagatcag      300

cccctaggat attgtactaa tggtgtatgc tcctactttg actactgggg ccagggaacc      360

ctggtcaccg tctcctcagg tggaggcggt tcaggcggag gtggcagcgg cggtggcggg      420

tcggacatcc agatgaccca gtctccatct tccgtgtctg catctgtagg agacagagtc      480

accatcactt gtcgggcgag tcagggtatt tacagctggt tagcctggta tcagcagaaa      540

ccagggaaag cccctaacct cctgatctat actgcatcca ctttacaaag tggggtccca      600

tcaaggttca gcggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcaa      660

cctgaagatt ttgcaactta ctattgtcaa caggctaaca ttttcccgct cactttcggc      720

ggagggacca aggtggagat caaagagtcc aaatatggtc ccccatgccc accatgccca      780

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact      840

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      900

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc     1080

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc     1140

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1200

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1320

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggtaa acccttttgg     1440

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttt     1500

attattttct gggtgaggag taagaggagc aggctcctgc acagtgacta catgaacatg     1560

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac     1620

ttcgcagcct atcgctcc                                                   1638


<210>  21
<211>  1764
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40DCR3ĺУźģ

<400>  21
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaaccctg acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga acaggctgag atctgacgac acggccgtgt attactgtgc gagagatcag      300

cccctaggat attgtactaa tggtgtatgc tcctactttg actactgggg ccagggaacc      360

ctggtcaccg tctcctcagg tggaggcggt tcaggcggag gtggcagcgg cggtggcggg      420

tcggacatcc agatgaccca gtctccatct tccgtgtctg catctgtagg agacagagtc      480

accatcactt gtcgggcgag tcagggtatt tacagctggt tagcctggta tcagcagaaa      540

ccagggaaag cccctaacct cctgatctat actgcatcca ctttacaaag tggggtccca      600

tcaaggttca gcggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcaa      660

cctgaagatt ttgcaactta ctattgtcaa caggctaaca ttttcccgct cactttcggc      720

ggagggacca aggtggagat caaagagtcc aaatatggtc ccccatgccc accatgccca      780

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact      840

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      900

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc     1080

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc     1140

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1200

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1320

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggtaa acccttttgg     1440

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttt     1500

attattttct gggtgaggag taagaggagc aggctcctgc acagtgacta catgaacatg     1560

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac     1620

ttcgcagcct atcgctccaa acggggcaga aagaagctcc tgtatatatt caaacaacca     1680

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1740

gaagaagaag gaggatgtga actg                                            1764


<210>  22
<211>  1764
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40DCR4ĺУźģ

<400>  22
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaaccctg acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga acaggctgag atctgacgac acggccgtgt attactgtgc gagagatcag      300

cccctaggat attgtactaa tggtgtatgc tcctactttg actactgggg ccagggaacc      360

ctggtcaccg tctcctcagg tggaggcggt tcaggcggag gtggcagcgg cggtggcggg      420

tcggacatcc agatgaccca gtctccatct tccgtgtctg catctgtagg agacagagtc      480

accatcactt gtcgggcgag tcagggtatt tacagctggt tagcctggta tcagcagaaa      540

ccagggaaag cccctaacct cctgatctat actgcatcca ctttacaaag tggggtccca      600

tcaaggttca gcggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcaa      660

cctgaagatt ttgcaactta ctattgtcaa caggctaaca ttttcccgct cactttcggc      720

ggagggacca aggtggagat caaagagtcc aaatatggtc ccccatgccc accatgccca      780

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact      840

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      900

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      960

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1020

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc     1080

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc     1140

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1200

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1260

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1320

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1380

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggtaa acccttttgg     1440

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttt     1500

attattttct gggtgaaacg gggcagaaag aagctcctgt atatattcaa acaaccattt     1560

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1620

gaagaaggag gatgtgaact gaggagtaag aggagcaggc tcctgcacag tgactacatg     1680

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca     1740

cgcgacttcg cagcctatcg ctcc                                            1764


<210>  23
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR G1 CARİ

<400>  23

Ala Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu 
1               5                   10                  15      


Leu Leu His Ala Ala Arg Pro Ser Asp Ile Leu Leu Thr Gln Ser Pro 
            20                  25                  30          


Val Ile Leu Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg 
        35                  40                  45              


Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr 
    50                  55                  60                  


Asn Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser 
65                  70                  75                  80  


Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro 
145                 150                 155                 160 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
                165                 170                 175     


Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro 
        195                 200                 205             


Phe Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val 
    210                 215                 220                 


Phe Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Phe Val Pro Val Phe Leu Pro 
            260                 265                 270         


Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    290                 295                 300                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
305                 310                 315                 320 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                325                 330                 335     


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Ser Lys Arg Ser Arg 
            340                 345                 350         


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
        355                 360                 365             


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
    370                 375                 380                 


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  24
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR G1 CARĺ

<400>  24
gccaccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccga gcgacatctt gctgactcag tctccagtca tcctgtctgt gagtccagga      120

gaaagagtca gtttctcctg cagggccagt cagagtattg gcacaaacat acactggtat      180

cagcaaagaa caaatggttc tccaaggctt ctcataaagt atgcttctga gtctatctct      240

gggatccctt ccaggtttag tggcagtgga tcagggacag attttactct tagcatcaac      300

agtgtggagt ctgaagatat tgcagattat tactgtcaac aaaataataa ctggccaacc      360

acgttcggtg ctgggaccaa gctggagctg aaaggtggag gcggttcagg cggaggtggc      420

agcggcggtg gcgggtcgca ggtgcagctg aagcagtcag gacctggcct agtgcagccc      480

tcacagagcc tgtccatcac ctgcacagtc tctggtttct cattaactaa ctatggtgta      540

cactgggttc gccagtctcc aggaaagggt ctggagtggc tgggagtgat atggagtggt      600

ggaaacacag actataatac acctttcaca tccagactga gcatcaacaa ggacaattcc      660

aagagccaag ttttctttaa aatgaacagt ctgcaatcta atgacacagc catatattac      720

tgtgccagag ccctcaccta ctatgattac gagtttgctt actggggcca agggactctg      780

gtcactgtct cttcgttcgt gccggtcttc ctgccagcga agcccaccac gacgccagcg      840

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag      900

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat      960

atctacatct gggcgcccct ggccgggact tgtggggtcc ttctcctgtc actggttatc     1020

accctttact gcaaccacag gagtaagagg agcaggctcc tgcacagtga ctacatgaac     1080

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc     1140

gacttcgcag cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctga     1500

taa                                                                   1503


<210>  25
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3ƵҰ

<400>  25

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  26
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EGFR G2 CARĺ

<400>  26
gccaccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccga gcgacatctt gctgactcag tctccagtca tcctgtctgt gagtccagga      120

gaaagagtca gtttctcctg cagggccagt cagagtattg gcacaaacat acactggtat      180

cagcaaagaa caaatggttc tccaaggctt ctcataaagt atgcttctga gtctatctct      240

gggatccctt ccaggtttag tggcagtgga tcagggacag attttactct tagcatcaac      300

agtgtggagt ctgaagatat tgcagattat tactgtcaac aaaataataa ctggccaacc      360

acgttcggtg ctgggaccaa gctggagctg aaaggtggag gcggttcagg cggaggtggc      420

agcggcggtg gcgggtcgca ggtgcagctg aagcagtcag gacctggcct agtgcagccc      480

tcacagagcc tgtccatcac ctgcacagtc tctggtttct cattaactaa ctatggtgta      540

cactgggttc gccagtctcc aggaaagggt ctggagtggc tgggagtgat atggagtggt      600

ggaaacacag actataatac acctttcaca tccagactga gcatcaacaa ggacaattcc      660

aagagccaag ttttctttaa aatgaacagt ctgcaatcta atgacacagc catatattac      720

tgtgccagag ccctcaccta ctatgattac gagtttgctt actggggcca agggactctg      780

gtcactgtct cttcgttcgt gccggtcttc ctgccagcga agcccaccac gacgccagcg      840

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag      900

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat      960

atctacatct gggcgcccct ggccgggact tgtggggtcc ttctcctgtc actggttatc     1020

accctttact gcaaccacag gagtaagagg agcaggctcc tgcacagtga ctacatgaac     1080

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc     1140

gacttcgcag cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1200

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1260

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1320

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1380

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1440

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctga     1500

taa                                                                   1503


<210>  27
<211>  2718
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PS328bĺ

<400>  27
ggcgcgcctt aaccctagaa agataatcat attgtgacgt acgttaaaga taatcatgcg       60

taaaattgac gcatgtctag aggtgtggaa agtccccagg ctccccagca ggcagaagta      120

tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca ggctccccag      180

caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaaggat ctgcgatcgc      240

tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa gttgggggga      300

ggggtcggca attgaacggg tgcctagaga aggtggcgcg gggtaaactg ggaaagtgat      360

gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat aagtgcagta      420

gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacagct gaagcttcga      480

ggggctcgca tctctccttc acgcgcccgc cgccctacct gaggccgcca tccacgccgg      540

ttgagtcgcg ttctgccgcc tcccgcctgt ggtgcctcct gaactgcgtc cgccgtctag      600

gtaagtttaa agctcaggtc gagaccgggc ctttgtccgg cgctcccttg gagcctacct      660

agactcagcc ggctctccac gctttgcctg accctgcttg ctcaactcta cgtctttgtt      720

tcgttttctg ttctgcgccg ttacagatcc aagctgtgac cggcgcctac gaattcggat      780

cctgcactag tgctgtcgac cagacatgat aagatacatt gatgagtttg gacaaaccac      840

aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt      900

tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt      960

tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag taaaacctct acaaatgtgg     1020

tagcatgcgt caattttacg cagactatct ttctagggtt aaatcgatcc cgctagcccc     1080

gatatcccct taattaagag ggggagacca aagggcgaga cgttaaggcc tcacgtgaca     1140

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     1200

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     1260

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     1320

ctcctgttcc gaccctgccg cttacgggat acctgtccgc ctttctccct tcgggaagcg     1380

tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     1440

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     1500

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     1560

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     1620

actacggcta cactagaaga acagtatttg gtatctgcgc tctgctgaag ccagttacct     1680

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     1740

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     1800

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     1860

tgccgtctca gaagaactcg tcaagaaggc gatagaaggc gatgcgctgc gaatcgggag     1920

cggcgatacc gtaaagcacg aggaagcggt cagcccattc gccgccaagc tcttcagcaa     1980

tatcacgggt agccaacgct atgtcctgat agcggtccgc cacacccagc cggccacagt     2040

cgatgaatcc agaaaagcgg ccattttcca ccatgatatt cggcaagcag gcatcgccat     2100

gggtcacgac gagatcctcg ccgtcgggca tgctcgcctt gagcctggcg aacagttcgg     2160

ctggcgcgag cccctgatgc tcttcgtcca gatcatcctg atcgacaaga ccggcttcca     2220

tccgagtacg tgctctctcg atgcgatgtt tcgcttggtg gtcgaatggg caggtagccg     2280

gatcaagcgt atgcagccgc cgcattgcat cagccatgat ggatactttc tcggcaggag     2340

caaggtgaga tgacaggaga tcctgccccg gcacttcgcc caatagcagc cagtcccttc     2400

ccgcttcagt gacaacgtcg agtacagctg cgcaaggaac gcccgtcgtg gccagccacg     2460

atagccgcgc tgcctcgtct tgcagttcat tcagggcacc ggacaggtcg gtcttgacaa     2520

aaagaaccgg gcgcccctgc gctgacagcc ggaacacggc ggcatcagag cagccgattg     2580

tctgttgtgc ccagtcatag ccgaatagcc tctccaccca agcggccgga gaacctgcgt     2640

gcaatccatc ttgttcaatc ataatattat tgaagcattt atcagggttc gtctcgtccc     2700

ggtctcctcc catgcatg                                                   2718


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD40-Fļ

<400>  28
acctcctgat ctatactg                                                     18


<210>  29
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD40-Rļ

<400>  29
gatggtgaga gtgaaatc                                                     18


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ̽Taqmanеļ

<400>  30
cactgccgct gaaccttgat g                                                 21


