                               SEQUENCE LISTING

<110> RUBIUS THERAPEUTICS, INC.
 
<120> GENE EDITING AND TARGETED TRANSCRIPTIONAL MODULATION FOR 
      ENGINEERING ERYTHROID CELLS

<130> R2081-7019WO

<140>
<141>

<150> 62/611,604
<151> 2017-12-29

<160> 31    

<170> PatentIn version 3.5

<210> 1
<211> 15
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas9 motif sequence"

<400> 1
Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile 
1               5                   10                  15  


<210> 2
<211> 8
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas9 motif sequence"

<400> 2
Ile Val Ile Glu Met Ala Arg Glu 
1               5               


<210> 3
<211> 27
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas9 motif sequence"

<400> 3
Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile 
1               5                   10                  15      


Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn 
            20                  25          


<210> 4
<211> 8
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas9 motif sequence"

<400> 4
His His Ala His Asp Ala Tyr Leu 
1               5               


<210> 5
<211> 205
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      4-1BBL sequence"

<400> 5
Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            20                  25                  30          


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        35                  40                  45              


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    50                  55                  60                  


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
65                  70                  75                  80  


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                85                  90                  95      


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            100                 105                 110         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        115                 120                 125             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    130                 135                 140                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
145                 150                 155                 160 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                165                 170                 175     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            180                 185                 190         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200                 205 


<210> 6
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Ala Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210> 7
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210> 8
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Arg Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210> 9
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Arg Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210> 10
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Arg Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Ile Lys Ile Asn Ser Trp Glu Ser Ser Arg Arg Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Asp Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210> 11
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met His His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210> 12
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Arg Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met His His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210> 13
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp 
            20                  25                  30          


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
145                 150                 155                 160 


Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        195                 200                 205             


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr 
    210                 215                 220                 


His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235             


<210> 14
<211> 567
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      PAL sequence"

<400> 14
Met Lys Thr Leu Ser Gln Ala Gln Ser Lys Thr Ser Ser Gln Gln Phe 
1               5                   10                  15      


Ser Phe Thr Gly Asn Ser Ser Ala Asn Val Ile Ile Gly Asn Gln Lys 
            20                  25                  30          


Leu Thr Ile Asn Asp Val Ala Arg Val Ala Arg Asn Gly Thr Leu Val 
        35                  40                  45              


Ser Leu Thr Asn Asn Thr Asp Ile Leu Gln Gly Ile Gln Ala Ser Cys 
    50                  55                  60                  


Asp Tyr Ile Asn Asn Ala Val Glu Ser Gly Glu Pro Ile Tyr Gly Val 
65                  70                  75                  80  


Thr Ser Gly Phe Gly Gly Met Ala Asn Val Ala Ile Ser Arg Glu Gln 
                85                  90                  95      


Ala Ser Glu Leu Gln Thr Asn Leu Val Trp Phe Leu Lys Thr Gly Ala 
            100                 105                 110         


Gly Asn Lys Leu Pro Leu Ala Asp Val Arg Ala Ala Met Leu Leu Arg 
        115                 120                 125             


Ala Asn Ser His Met Arg Gly Ala Ser Gly Ile Arg Leu Glu Leu Ile 
    130                 135                 140                 


Lys Arg Met Glu Ile Phe Leu Asn Ala Gly Val Thr Pro Tyr Val Tyr 
145                 150                 155                 160 


Glu Phe Gly Ser Ile Gly Ala Ser Gly Asp Leu Val Pro Leu Ser Tyr 
                165                 170                 175     


Ile Thr Gly Ser Leu Ile Gly Leu Asp Pro Ser Phe Lys Val Asp Phe 
            180                 185                 190         


Asn Gly Lys Glu Met Asp Ala Pro Thr Ala Leu Arg Gln Leu Asn Leu 
        195                 200                 205             


Ser Pro Leu Thr Leu Leu Pro Lys Glu Gly Leu Ala Met Met Asn Gly 
    210                 215                 220                 


Thr Ser Val Met Thr Gly Ile Ala Ala Asn Cys Val Tyr Asp Thr Gln 
225                 230                 235                 240 


Ile Leu Thr Ala Ile Ala Met Gly Val His Ala Leu Asp Ile Gln Ala 
                245                 250                 255     


Leu Asn Gly Thr Asn Gln Ser Phe His Pro Phe Ile His Asn Ser Lys 
            260                 265                 270         


Pro His Pro Gly Gln Leu Trp Ala Ala Asp Gln Met Ile Ser Leu Leu 
        275                 280                 285             


Ala Asn Ser Gln Leu Val Arg Asp Glu Leu Asp Gly Lys His Asp Tyr 
    290                 295                 300                 


Arg Asp His Glu Leu Ile Gln Asp Arg Tyr Ser Leu Arg Cys Leu Pro 
305                 310                 315                 320 


Gln Tyr Leu Gly Pro Ile Val Asp Gly Ile Ser Gln Ile Ala Lys Gln 
                325                 330                 335     


Ile Glu Ile Glu Ile Asn Ser Val Thr Asp Asn Pro Leu Ile Asp Val 
            340                 345                 350         


Asp Asn Gln Ala Ser Tyr His Gly Gly Asn Phe Leu Gly Gln Tyr Val 
        355                 360                 365             


Gly Met Gly Met Asp His Leu Arg Tyr Tyr Ile Gly Leu Leu Ala Lys 
    370                 375                 380                 


His Leu Asp Val Gln Ile Ala Leu Leu Ala Ser Pro Glu Phe Ser Asn 
385                 390                 395                 400 


Gly Leu Pro Pro Ser Leu Leu Gly Asn Arg Glu Arg Lys Val Asn Met 
                405                 410                 415     


Gly Leu Lys Gly Leu Gln Ile Cys Gly Asn Ser Ile Met Pro Leu Leu 
            420                 425                 430         


Thr Phe Tyr Gly Asn Ser Ile Ala Asp Arg Phe Pro Thr His Ala Glu 
        435                 440                 445             


Gln Phe Asn Gln Asn Ile Asn Ser Gln Gly Tyr Thr Ser Ala Thr Leu 
    450                 455                 460                 


Ala Arg Arg Ser Val Asp Ile Phe Gln Asn Tyr Val Ala Ile Ala Leu 
465                 470                 475                 480 


Met Phe Gly Val Gln Ala Val Asp Leu Arg Thr Tyr Lys Lys Thr Gly 
                485                 490                 495     


His Tyr Asp Ala Arg Ala Cys Leu Ser Pro Ala Thr Glu Arg Leu Tyr 
            500                 505                 510         


Ser Ala Val Arg His Val Val Gly Gln Lys Pro Thr Ser Asp Arg Pro 
        515                 520                 525             


Tyr Ile Trp Asn Asp Asn Glu Gln Gly Leu Asp Glu His Ile Ala Arg 
    530                 535                 540                 


Ile Ser Ala Asp Ile Ala Ala Gly Gly Val Ile Val Gln Ala Val Gln 
545                 550                 555                 560 


Asp Ile Leu Pro Cys Leu His 
                565         


<210> 15
<211> 328
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Y vb Asparaginase sequence"

<400> 15
Met Ala Asp Lys Leu Pro Asn Ile Val Ile Leu Ala Thr Gly Gly Thr 
1               5                   10                  15      


Ile Ala Gly Ser Ala Ala Thr Gly Thr Gln Thr Thr Gly Tyr Lys Ala 
            20                  25                  30          


Gly Ala Leu Gly Val Asp Thr Leu Ile Asn Ala Val Pro Glu Val Lys 
        35                  40                  45              


Lys Leu Ala Asn Val Lys Gly Glu Gln Phe Ser Asn Met Ala Ser Glu 
    50                  55                  60                  


Asn Met Thr Gly Asp Val Val Leu Lys Leu Ser Gln Arg Val Asn Glu 
65                  70                  75                  80  


Leu Leu Ala Arg Asp Asp Val Asp Gly Val Val Ile Thr His Gly Thr 
                85                  90                  95      


Asp Thr Val Glu Glu Ser Ala Tyr Phe Leu His Leu Thr Val Lys Ser 
            100                 105                 110         


Asp Lys Pro Val Val Phe Val Ala Ala Met Arg Pro Ala Thr Ala Ile 
        115                 120                 125             


Ser Ala Asp Gly Pro Met Asn Leu Leu Glu Ala Val Arg Val Ala Gly 
    130                 135                 140                 


Asp Lys Gln Ser Arg Gly Arg Gly Val Met Val Val Leu Asn Asp Arg 
145                 150                 155                 160 


Ile Gly Ser Ala Arg Tyr Ile Thr Lys Thr Asn Ala Ser Thr Leu Asp 
                165                 170                 175     


Thr Phe Lys Ala Asn Glu Glu Gly Tyr Leu Gly Val Ile Ile Gly Asn 
            180                 185                 190         


Arg Ile Tyr Tyr Gln Asn Arg Ile Asp Lys Leu His Thr Thr Arg Ser 
        195                 200                 205             


Val Phe Asp Val Arg Gly Leu Thr Ser Leu Pro Lys Val Asp Ile Leu 
    210                 215                 220                 


Tyr Gly Tyr Gln Asp Asp Pro Glu Tyr Leu Tyr Asp Ala Ala Ile Gln 
225                 230                 235                 240 


His Gly Val Lys Gly Ile Val Tyr Ala Gly Met Gly Ala Gly Ser Val 
                245                 250                 255     


Ser Val Arg Gly Ile Ala Gly Met Arg Lys Ala Met Glu Lys Gly Val 
            260                 265                 270         


Val Val Ile Arg Ser Thr Arg Thr Gly Asn Gly Ile Val Pro Pro Asp 
        275                 280                 285             


Glu Glu Leu Pro Gly Leu Val Ser Asp Ser Leu Asn Pro Ala His Ala 
    290                 295                 300                 


Arg Ile Leu Leu Met Leu Ala Leu Thr Arg Thr Ser Asp Pro Lys Val 
305                 310                 315                 320 


Ile Gln Glu Tyr Phe His Thr Tyr 
                325             


<210> 16
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Glu Ser Asn Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Val Asp Ile Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Trp Asp Tyr Ala Ile Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 17
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Lys Ser 
            20                  25                  30          


Tyr Gly Asn Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Gln Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 18
<211> 160
<212> PRT
<213> Homo sapiens

<400> 18
Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


<210> 19
<211> 448
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Clotting Factor X sequence"

<400> 19
Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg Glu 
1               5                   10                  15      


Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu 
            20                  25                  30          


Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp 
        35                  40                  45              


Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly 
    50                  55                  60                  


Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn 
65                  70                  75                  80  


Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys 
                85                  90                  95      


Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala 
            100                 105                 110         


Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly 
        115                 120                 125             


Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg Ser Val 
    130                 135                 140                 


Ala Gln Ala Thr Ser Ser Ser Gly Glu Ala Pro Asp Ser Ile Thr Trp 
145                 150                 155                 160 


Lys Pro Tyr Asp Ala Ala Asp Leu Asp Pro Thr Glu Asn Pro Phe Asp 
                165                 170                 175     


Leu Leu Asp Phe Asn Gln Thr Gln Pro Glu Arg Gly Asp Asn Asn Leu 
            180                 185                 190         


Thr Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp 
        195                 200                 205             


Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr 
    210                 215                 220                 


Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln 
225                 230                 235                 240 


Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu 
                245                 250                 255     


Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn 
            260                 265                 270         


Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu 
        275                 280                 285             


Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro 
    290                 295                 300                 


Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile 
305                 310                 315                 320 


Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg 
                325                 330                 335     


Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu 
            340                 345                 350         


Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp 
        355                 360                 365             


Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val 
    370                 375                 380                 


Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly 
385                 390                 395                 400 


Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr 
                405                 410                 415     


Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro 
            420                 425                 430         


Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
        435                 440                 445             


<210> 20
<211> 25
<212> DNA
<213> Homo sapiens

<400> 20
tttcctccgg acgcggccgt ctagc                                             25


<210> 21
<211> 25
<212> DNA
<213> Homo sapiens

<400> 21
tttcgcgcgg cgctgggccc cactg                                             25


<210> 22
<211> 25
<212> DNA
<213> Homo sapiens

<400> 22
tttgcgacaa tgctcgctag tcccg                                             25


<210> 23
<211> 25
<212> DNA
<213> Homo sapiens

<400> 23
tttcactccc accctcgcgc ttcag                                             25


<210> 24
<211> 490
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 24
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccga atttctacta agtgtagatc tccggacgcg gccgtctagc      360

aatttctact aagtgtagat gcgcggcgct gggccccact gaatttctac taagtgtaga      420

tcgacaatgc tcgctagtcc cgaatttcta ctaagtgtag atactcccac cctcgcgctt      480

cagttttttt                                                             490


<210> 25
<211> 1775
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Ala 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His Lys Arg  Pro Ala Ala 
    1220                 1225                 1230             


Thr Lys  Lys Ala Gly Gln Ala  Lys Lys Lys Lys Glu  Ala Ser Gly 
    1235                 1240                 1245             


Ser Gly  Arg Ala Asp Ala Leu  Asp Asp Phe Asp Leu  Asp Met Leu 
    1250                 1255                 1260             


Gly Ser  Asp Ala Leu Asp Asp  Phe Asp Leu Asp Met  Leu Gly Ser 
    1265                 1270                 1275             


Asp Ala  Leu Asp Asp Phe Asp  Leu Asp Met Leu Gly  Ser Asp Ala 
    1280                 1285                 1290             


Leu Asp  Asp Phe Asp Leu Asp  Met Leu Ile Asn Ser  Arg Ser Ser 
    1295                 1300                 1305             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Gly Ser Gln  Tyr Leu Pro 
    1310                 1315                 1320             


Asp Thr  Asp Asp Arg His Arg  Ile Glu Glu Lys Arg  Lys Arg Thr 
    1325                 1330                 1335             


Tyr Glu  Thr Phe Lys Ser Ile  Met Lys Lys Ser Pro  Phe Ser Gly 
    1340                 1345                 1350             


Pro Thr  Asp Pro Arg Pro Pro  Pro Arg Arg Ile Ala  Val Pro Ser 
    1355                 1360                 1365             


Arg Ser  Ser Ala Ser Val Pro  Lys Pro Ala Pro Gln  Pro Tyr Pro 
    1370                 1375                 1380             


Phe Thr  Ser Ser Leu Ser Thr  Ile Asn Tyr Asp Glu  Phe Pro Thr 
    1385                 1390                 1395             


Met Val  Phe Pro Ser Gly Gln  Ile Ser Gln Ala Ser  Ala Leu Ala 
    1400                 1405                 1410             


Pro Ala  Pro Pro Gln Val Leu  Pro Gln Ala Pro Ala  Pro Ala Pro 
    1415                 1420                 1425             


Ala Pro  Ala Met Val Ser Ala  Leu Ala Gln Ala Pro  Ala Pro Val 
    1430                 1435                 1440             


Pro Val  Leu Ala Pro Gly Pro  Pro Gln Ala Val Ala  Pro Pro Ala 
    1445                 1450                 1455             


Pro Lys  Pro Thr Gln Ala Gly  Glu Gly Thr Leu Ser  Glu Ala Leu 
    1460                 1465                 1470             


Leu Gln  Leu Gln Phe Asp Asp  Glu Asp Leu Gly Ala  Leu Leu Gly 
    1475                 1480                 1485             


Asn Ser  Thr Asp Pro Ala Val  Phe Thr Asp Leu Ala  Ser Val Asp 
    1490                 1495                 1500             


Asn Ser  Glu Phe Gln Gln Leu  Leu Asn Gln Gly Ile  Pro Val Ala 
    1505                 1510                 1515             


Pro His  Thr Thr Glu Pro Met  Leu Met Glu Tyr Pro  Glu Ala Ile 
    1520                 1525                 1530             


Thr Arg  Leu Val Thr Gly Ala  Gln Arg Pro Pro Asp  Pro Ala Pro 
    1535                 1540                 1545             


Ala Pro  Leu Gly Ala Pro Gly  Leu Pro Asn Gly Leu  Leu Ser Gly 
    1550                 1555                 1560             


Asp Glu  Asp Phe Ser Ser Ile  Ala Asp Met Asp Phe  Ser Ala Leu 
    1565                 1570                 1575             


Leu Gly  Ser Gly Ser Gly Ser  Arg Asp Ser Arg Glu  Gly Met Phe 
    1580                 1585                 1590             


Leu Pro  Lys Pro Glu Ala Gly  Ser Ala Ile Ser Asp  Val Phe Glu 
    1595                 1600                 1605             


Gly Arg  Glu Val Cys Gln Pro  Lys Arg Ile Arg Pro  Phe His Pro 
    1610                 1615                 1620             


Pro Gly  Ser Pro Trp Ala Asn  Arg Pro Leu Pro Ala  Ser Leu Ala 
    1625                 1630                 1635             


Pro Thr  Pro Thr Gly Pro Val  His Glu Pro Val Gly  Ser Leu Thr 
    1640                 1645                 1650             


Pro Ala  Pro Val Pro Gln Pro  Leu Asp Pro Ala Pro  Ala Val Thr 
    1655                 1660                 1665             


Pro Glu  Ala Ser His Leu Leu  Glu Asp Pro Asp Glu  Glu Thr Ser 
    1670                 1675                 1680             


Gln Ala  Val Lys Ala Leu Arg  Glu Met Ala Asp Thr  Val Ile Pro 
    1685                 1690                 1695             


Gln Lys  Glu Glu Ala Ala Ile  Cys Gly Gln Met Asp  Leu Ser His 
    1700                 1705                 1710             


Pro Pro  Pro Arg Gly His Leu  Asp Glu Leu Thr Thr  Thr Leu Glu 
    1715                 1720                 1725             


Ser Met  Thr Glu Asp Leu Asn  Leu Asp Ser Pro Leu  Thr Pro Glu 
    1730                 1735                 1740             


Leu Asn  Glu Ile Leu Asp Thr  Phe Leu Asn Asp Glu  Cys Leu Leu 
    1745                 1750                 1755             


His Ala  Met His Ile Ser Thr  Gly Leu Ser Ile Phe  Asp Thr Ser 
    1760                 1765                 1770             


Leu Phe  
    1775 


<210> 26
<211> 1099
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 26
Met Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
1               5                   10                  15      


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
            20                  25                  30          


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
        35                  40                  45              


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
    50                  55                  60                  


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
65                  70                  75                  80  


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
                85                  90                  95      


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
            100                 105                 110         


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
        115                 120                 125             


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
    130                 135                 140                 


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
145                 150                 155                 160 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala 
                165                 170                 175     


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            180                 185                 190         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        195                 200                 205             


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
    210                 215                 220                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
225                 230                 235                 240 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
                245                 250                 255     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            260                 265                 270         


Pro Glu Gln Val Val Ala Ile Ala Ser Asn His Gly Gly Lys Gln Ala 
        275                 280                 285             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    290                 295                 300                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn His Gly Gly Lys 
305                 310                 315                 320 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
                325                 330                 335     


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
            340                 345                 350         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        355                 360                 365             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
    370                 375                 380                 


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
385                 390                 395                 400 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                405                 410                 415     


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            420                 425                 430         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        435                 440                 445             


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    450                 455                 460                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
465                 470                 475                 480 


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
                485                 490                 495     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
            500                 505                 510         


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
        515                 520                 525             


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
    530                 535                 540                 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn His Gly Gly Lys Gln Ala 
545                 550                 555                 560 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
                565                 570                 575     


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
            580                 585                 590         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        595                 600                 605             


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn His Gly 
    610                 615                 620                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
625                 630                 635                 640 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
                645                 650                 655     


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
            660                 665                 670         


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
        675                 680                 685             


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
    690                 695                 700                 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
705                 710                 715                 720 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                725                 730                 735     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            740                 745                 750         


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
        755                 760                 765             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
    770                 775                 780                 


Gln Val Val Ala Ile Ala Ser Asn His Gly Gly Lys Gln Ala Leu Glu 
785                 790                 795                 800 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                805                 810                 815     


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 
            820                 825                 830         


Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala 
        835                 840                 845             


Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg 
    850                 855                 860                 


Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Ala Leu 
865                 870                 875                 880 


Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu Arg Thr Ser His Arg Val 
                885                 890                 895     


Ala Asp His Ala Gln Val Val Arg Val Leu Gly Phe Phe Gln Cys His 
            900                 905                 910         


Ser His Pro Ala Gln Ala Phe Asp Asp Ala Met Thr Gln Phe Gly Met 
        915                 920                 925             


Ser Arg His Gly Leu Leu Gln Leu Phe Arg Arg Val Gly Val Thr Glu 
    930                 935                 940                 


Leu Glu Ala Arg Ser Gly Thr Leu Pro Pro Ala Ser Gln Arg Trp Asp 
945                 950                 955                 960 


Arg Ile Leu Gln Ala Ser Gly Met Lys Arg Ala Lys Pro Ser Pro Thr 
                965                 970                 975     


Ser Thr Gln Thr Pro Asp Gln Ala Ser Leu His Ala Phe Ala Asp Ser 
            980                 985                 990         


Leu Glu Arg Asp Leu Asp Ala Pro  Ser Pro Met His Glu  Gly Asp Gln 
        995                 1000                 1005             


Thr Arg  Ala Ser Ala Ser Pro  Lys Lys Lys Arg Lys  Val Glu Ala 
    1010                 1015                 1020             


Ser Met  Asp Ala Lys Ser Leu  Thr Ala Trp Ser Arg  Thr Leu Val 
    1025                 1030                 1035             


Thr Phe  Lys Asp Val Phe Val  Asp Phe Thr Arg Glu  Glu Trp Lys 
    1040                 1045                 1050             


Leu Leu  Asp Thr Ala Gln Gln  Ile Val Tyr Arg Asn  Val Met Leu 
    1055                 1060                 1065             


Glu Asn  Tyr Lys Asn Leu Val  Ser Leu Gly Tyr Gln  Leu Thr Lys 
    1070                 1075                 1080             


Pro Asp  Val Ile Leu Arg Leu  Glu Lys Gly Glu Glu  Pro Trp Leu 
    1085                 1090                 1095             


Val 
    


<210> 27
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 27
uugcacuacu aaaguca                                                      17


<210> 28
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 28
cuuguuuaga gcucau                                                       16


<210> 29
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 29
cuuguuuaga gcuccau                                                      17


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
cccggcccac agcgacccgt                                                   20


<210> 31
<211> 8
<212> PRT
<213> Gallus gallus

<400> 31
Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


