                               SEQUENCE LISTING

<110> SYNTHORX, INC.
 
<120> UNNATURAL BASE PAIR COMPOSITIONS AND METHODS OF USE

<130> 46085-712.601

<140>
<141>

<150> 62/612,062
<151> 2017-12-29

<160> 32    

<170> PatentIn version 3.5

<210> 1
<211> 2540
<212> DNA
<213> Escherichia coli

<400> 1
aaaccaggct cccccaagcc tggttgtagg ctggagctgc ttcgaagttc ctatactttc       60

tagagaatag gaacttcgaa ctgcaggtcg acggatcccc ggaatttttt tataaataca      120

cagccaatca aacgaaacca ggctataatc aagcctggtt ttttgatgga attacagcgt      180

ggcgcaggca ggttttatct taacccgaca ctggcgggac accccgcaag ggacagaagt      240

ctccttctgg ctggcgacgg acaacgggcc gttgcaggtt acgcttgcac cgcaagagtc      300

cgtggcgttt attcccgccg atcaggttcc ccgcgctcag catattttgc agggtgaaca      360

aggcgttcgc ctgacaccgc tggcgttaaa ggattttcac cgccagccgg tgtatggcct      420

ttactgtcgc gcccatcgcc aattgatgaa ttacgaaaag cgcctgcgtg aaggtggcgt      480

taccgtctac gaggccgatg tgcgcccgcc agaacgctat ctgatggagc ggtttatcac      540

ctcaccggtg tgggtcgagg gtgatatgca caatggcgct atcgttaatg cccgtctgaa      600

accgcatccc gactatcgtc cgccgctcaa gtgggtttct attgatattg aaaccacccg      660

ccacggtgag ctgtactgca tcggcctgga aggctgcggg cagcgcatcg tttatatgct      720

ggggccagag aatggcgacg cctccgcgct cgattttgaa ctggaatacg tcgccagccg      780

cccgcagcta ctggaaaaac tcaacgcctg gtttgccaac tacgatcctg atgtgatcat      840

cggttggaac gtggtgcagt tcgatctgcg aatgctgcaa aaacatgccg agcgttaccg      900

tattccgctg cggctggggc gcgataacag tgagctggag tggcgcgagc acggctttaa      960

aaacggcgtc ttttttgccc aggctaaagg tcggctaatt atcgacggta tcgaggcgct     1020

gaaatccgcg ttctggaatt tctcttcatt ctcgctggaa accgtcgctc aggagttatt     1080

aggcgaagga aaatctatcg ataacccgtg ggatcgaatg gacgaaattg accgccgttt     1140

cgccgaagat aaacctgcgc tggcgactta taacctgaaa gattgcgagc tggtgacgca     1200

gattttccat aaaactgaaa tcatgccatt tttactcgaa cgagcgacgg tgaacggcct     1260

gccggtagac cgccacgggg gatcggtggc ggcgtttggt catctctatt ttcctcgtat     1320

gcaccgcgct ggttatgtcg cgcctaatct cggcgaagtg ccgccacacg ccagccctgg     1380

cggctacgtg atggattcac ggccagggct ttatgattcg gtactggtgc tggactataa     1440

aagcctgtac ccgtcgatca tccgcacctt tctgattgat cccgtcgggc tggtggaagg     1500

catggcgcag cctgatccag agcacagtac cgaaggtttt ctcgatgcct ggttctcgcg     1560

agaaaaacat tgcctgccgg agattgtgac taacatctgg cacgggcgcg atgaagccaa     1620

acgccagggt aacaaaccgc tgtcgcaggc gctgaaaatc atcatgaatg ccttttatgg     1680

cgtgctcggc accaccgcct gccgcttctt cgatccgcgg ctggcatcgt cgatcaccat     1740

gcgtggtcat cagatcatgc ggcaaaccaa agcgttgatt gaagcacagg gctacgacgt     1800

tatctacggc gataccgact caacgtttgt ctggctgaaa ggcgcacatt cggaagaaga     1860

agcggcgaaa atcggtcgtg cactggtgca gcacgttaac gcctggtggg cggaaacgct     1920

gcaaaaacaa cggctgacca gcgcattaga actggagtat gaaacccatt tctgccgttt     1980

tctgatgcca accattcgcg gagccgatac cggcagtaaa aagcgttatg ccggactgat     2040

tcaggagggc gacaagcagc ggatggtgtt taaagggctg gaaaccgtgc gcaccgactg     2100

gacgccgctg gcccagcagt ttcagcagga gctatacctg cgcatcttcc gcaacgagcc     2160

atatcaggaa tatgtacgcg aaaccatcga caaactgatg gcgggtgaac tggatgcgcg     2220

actggtttac cgtaaacgcc ttcgccgtcc gctgagcgag tatcagcgta atgtgccgcc     2280

tcatgtacgc gccgctcgcc ttgccgatga agaaaaccaa aagcgtggtc gccccttgca     2340

atatcagaat cgcggcacca ttaagtacgt atggaccacc aacggcccgg agccgctgga     2400

ctaccaacgt tcaccactgg attacgaaca ctatctgacc cgccagctac aacccgtggc     2460

ggagggaata ctccctttta ttgaggataa ttttgctaca cttatgaccg ggcaacttgg     2520

gctattttga gcaaaaaaaa                                                 2540


<210> 2
<211> 2436
<212> DNA
<213> Escherichia coli

<400> 2
tgactgtata aaaccacagc caatcaaacg aaaccaggct ataatcaagc ctggtttttt       60

gatggaatta cagcgtggcg caggcaggtt ttatcttaac ccgacactgg cgggacaccc      120

cgcaagggac agaagtctcc ttctggctgg cgacggacaa cgggccgttg caggttacgc      180

ttgcaccgca agagtccgtg gcgtttattc ccgccgatca ggttccccgc gctcagcata      240

ttttgcaggg tgaacaaggc gttcgcctga caccgctggc gttaaaggat tttcaccgcc      300

agccggtgta tggcctttac tgtcgcgccc atcgccaatt gatgaattac gaaaagcgcc      360

tgcgtgaagg tggcgttacc gtctacgagg ccgatgtgcg cccgccagaa cgctatctga      420

tggagcggtt tatcacctca ccggtgtggg tcgagggtga tatgcacaat ggcgctatcg      480

ttaatgcccg tctgaaaccg catcccgact atcgtccgcc gctcaagtgg gtttctattg      540

atattgaaac cacccgccac ggtgagctgt actgcatcgg cctggaaggc tgcgggcagc      600

gcatcgttta tatgctgggg ccagagaatg gcgacgcctc cgcgctcgat tttgaactgg      660

aatacgtcgc cagccgcccg cagctactgg aaaaactcaa cgcctggttt gccaactacg      720

atcctgatgt gatcatcggt tggaacgtgg tgcagttcga tctgcgaatg ctgcaaaaac      780

atgccgagcg ttaccgtatt ccgctgcggc tggggcgcga taacagtgag ctggagtggc      840

gcgagcacgg ctttaaaaac ggcgtctttt ttgcccaggc taaaggtcgg ctaattatcg      900

acggtatcga ggcgctgaaa tccgcgttct ggaatttctc ttcattctcg ctggaaaccg      960

tcgctcagga gttattaggc gaaggaaaat ctatcgataa cccgtgggat cgaatggacg     1020

aaattgaccg ccgtttcgcc gaagataaac ctgcgctggc gacttataac ctgaaagatt     1080

gcgagctggt gacgcagatt ttccataaaa ctgaaatcat gccattttta ctcgaacgag     1140

cgacggtgaa cggcctgccg gtagaccgcc acgggggatc ggtggcggcg tttggtcatc     1200

tctattttcc tcgtatgcac cgcgctggtt atgtcgcgcc taatctcggc gaagtgccgc     1260

cacacgccag ccctggcggc tacgtgatgg attcacggcc agggctttat gattcggtac     1320

tggtgctgga ctataaaagc ctgtacccgt cgatcatccg cacctttctg attgatcccg     1380

tcgggctggt ggaaggcatg gcgcagcctg atccagagca cagtaccgaa ggttttctcg     1440

atgcctggtt ctcgcgagaa aaacattgcc tgccggagat tgtgactaac atctggcacg     1500

ggcgcgatga agccaaacgc cagggtaaca aaccgctgtc gcaggcgctg aaaatcatca     1560

tgaatgcctt ttatggcgtg ctcggcacca ccgcctgccg cttcttcgat ccgcggctgg     1620

catcgtcgat caccatgcgt ggtcatcaga tcatgcggca aaccaaagcg ttgattgaag     1680

cacagggcta cgacgttatc tacggcgata ccgactcaac gtttgtctgg ctgaaaggcg     1740

cacattcgga agaagaagcg gcgaaaatcg gtcgtgcact ggtgcagcac gttaacgcct     1800

ggtgggcgga aacgctgcaa aaacaacggc tgaccagcgc attagaactg gagtatgaaa     1860

cccatttctg ccgttttctg atgccaacca ttcgcggagc cgataccggc agtaaaaagc     1920

gttatgccgg actgattcag gagggcgaca agcagcggat ggtgtttaaa gggctggaaa     1980

ccgtgcgcac cgactggacg ccgctggccc agcagtttca gcaggagcta tacctgcgca     2040

tcttccgcaa cgagccatat caggaatatg tacgcgaaac catcgacaaa ctgatggcgg     2100

gtgaactgga tgcgcgactg gtttaccgta aacgccttcg ccgtccgctg agcgagtatc     2160

agcgtaatgt gccgcctcat gtacgcgccg ctcgccttgc cgatgaagaa aaccaaaagc     2220

gtggtcgccc cttgcaatat cagaatcgcg gcaccattaa gtacgtatgg accaccaacg     2280

gcccggagcc gctggactac caacgttcac cactggatta cgaacactat ctgacccgcc     2340

agctacaacc cgtggcggag ggaatactcc cttttattga ggataatttt gctacactta     2400

tgaccgggca acttgggcta ttttgagcaa aaaaaa                               2436


<210> 3
<211> 2008
<212> DNA
<213> Escherichia coli

<400> 3
ttattgcacg aagcgcgagg taacgtactg gctgtaatca ttcgctacag ccgggacctt       60

gccctgctct ttcaaaaact gcgcggtgtc gatgatcgct ttgttcaccg gtccggtcag      120

ttctgccgtt tgttgctgcg gcgtcagata ggtattcccc ttcaccagcc ccggaacgtc      180

accttcaggc acgccgctta accgcgccag tttgctgatg ttttccggct gtttcagcca      240

cgcgtctggg ttagcaatgt acggttgctg agcatcgatg gcgcttttgg cgaacgcttt      300

caccacctca ggatgtttct cggcaaaatc tttgcgcacc acccagacgt ccagcgttgg      360

cgcaccccac tgcccgacct gttcagaatc ggtcagcact ttgccgtctt tttccagggc      420

gttaaccgcc ggtgcccaga cataagcacc atcaatatct ccccgctgcc atgcagcgat      480

aatcgcgggc ggctgcaggt tcacaatctc cacttgccca ggtttaatgc cccagtgttt      540

cagcgctgcc agcaggctgt agtgggtggt agagataaac ggtacggcga tgcgtttgcc      600

aatcagatct tccggtttgc tgatagtttt ctttaccacc agcgcttctg agttacccag      660

ttttgacgcc agcaagaaga cttcaatcgg cacctgttgg ctggctgcaa ccgctaacgg      720

gctggaacca aggttgccga tttgcacgtc gccagaagcc agcgcccgca cgatgctggc      780

tccgctgtca aacttacgcc agtccacggt tgctccgctt tctttagcaa aggtgttgtc      840

ggcctgagcc actttcgccg gttcggctga ggtttgatac gccacggtga cgttcaccgc      900

ctgtgcctga aaagcgatga atgccagtgc ggcaagaagt gtgtttcgcg atgaaattgc      960

catgattgtc tgctcccctg tcttgttatg ggagcagtat tcaggaataa aaacattcat     1020

taaaagaatt agtcgttatc gcacagatga ttttattctt agcaaaaaaa cggtgatgct     1080

gccaacttac tgatttagtg tatgatggtg tttttgaggt gctccagtgg cttctgtttc     1140

tatcagctgt ccctcctgtt cagctactga cggggtggtg cgtaacggca aaagcaccgc     1200

cggacatcag cgctatctct gctctcactg ccgtaaaaca tggcaactgc agttcactta     1260

caccgcttct caacccggta cgcaccagaa aatcattgat atggccatga atggcgttgg     1320

atgccgggca actgcccgca ttatgggcgt tggcctcaac acgattttac gtcacttaaa     1380

aaactcaggc cgcagtcggt aacctcgcgc atacagccgg gcagtgacgt catcgtctgc     1440

gcggaaatgg acgaacagtg gggctatgtc ggggctaaat cgcgccagcg ctggctgttt     1500

tacgcgtatg acaggctccg gaagacggtt gttgcgcacg tattcggtga acgcactatg     1560

gcgacgctgg ggcgtcttat gagcctgatg tcaccctttg acgtggtgat atggatgacg     1620

gatggctggc cgctgtatga atcccgcctg aagggaaagc tgcacgtaat cagcaagcga     1680

tatacgcagc gaattgagcg gcataacctg aatctgaggc agcacctggc acggctggga     1740

cggaagtcgc tgtcgttctc aaaatcggtg gagctgcatg acaaagtcat cgggcattat     1800

ctgaacataa aacactatca ataagttgga gtcattacca ggccgacaaa atggaggcaa     1860

agaccaacaa agaaaagtag ttaacctagg ctgctgccac cgctgagcaa taagactcct     1920

gttgatagat ccagtaatga cctcagaact ccatctggat ttgttcagaa cgctcggttg     1980

ccgccgggcg ttttttattg gtgagaat                                        2008


<210> 4
<211> 17210
<212> DNA
<213> Escherichia coli

<400> 4
ttattgcacg aagcgcgagg taacgtactg gctgtaatca ttcgctacag ccgggacctt       60

gccctgctct ttcaaaaact gcgcggtgtc gatgatcgct ttgttcaccg gtccggtcag      120

ttctgccgtt tgttgctgcg gcgtcagata ggtattcccc ttcaccagcc ccggaacgtc      180

accttcaggc acgccgctta accgcgccag tttgctgatg ttttccggct gtttcagcca      240

cgcgtctggg ttagcaatgt acggttgctg agcatcgatg gcgcttttgg cgaacgcttt      300

caccacctca ggatgtttct cggcaaaatc tttgcgcacc acccagacgt ccagcgttgg      360

cgcaccccac tgcccgacct gttcagaatc ggtcagcact ttgccgtctt tttccagggc      420

gttaaccgcc ggtgcccaga cataagcacc atcaatatct ccccgctgcc atgcagcgat      480

aatcgcgggc ggctgcaggt tcacaatctc cacttgccca ggtttaatgc cccagtgttt      540

cagcgctgcc agcaggctgt agtgggtggt agagataaac ggtacggcga tgcgtttgcc      600

aatcagatct tccggtttgc tgatagtttt ctttaccacc agcgcttctg agttacccag      660

ttttgacgcc agcaagaaga cttcaatcgg cacctgttgg ctggctgcaa ccgctaacgg      720

gctggaacca aggttgccga tttgcacgtc gccagaagcc agcgcccgca cgatgctggc      780

tccgctgtca aacttacgcc agtccacggt tgctccgctt tctttagcaa aggtgttgtc      840

ggcctgagcc actttcgccg gttcggctga ggtttgatac gccacggtga cgttcaccgc      900

ctgtgcctga aaagcgatga atgccagtgc ggcaagaagt gtgtttcgcg atgaaattgc      960

catgattgtc tgctcccctg tcttgttatg ggagcagtat tcaggaataa aaacattcat     1020

taaaagaatt agtcgttatc gcacagatga ttttattctt agcaaaaaaa ctgtaggctg     1080

gagctgcttg aagttcctat actttctaga gaataggaac ttcgaactgc aggtcgacgg     1140

atccccggaa ttagaacgta atttacctgc cggaacttat tcactccgac aagaacttat     1200

ccgtacagga gattaaaatg ataaaacgga cgttattagc ggcggccatt tttagcgcat     1260

tgcccgctta tgccgggtta acttccatta ccgcgggcta cgattttacc gattattctg     1320

gcgatcatgg caaccgtaat ttagcgtatg ctgaactggt ggcgaaagtt gaaaacgcaa     1380

cgctgctttt taatctttcc caggggcgtc gtgattatga aactgaacat ttcaatgcca     1440

ctcgcggtca gggtgcggtc tggtataaat ggaataactg gctgacaacc cgaacgggta     1500

ttgcctttgc ggataatacg ccggtctttg cccgccagga ttttcgtcag gatattaacc     1560

tggccctgtt gccaaaaacg cttttcacga ccggttatcg ctacactaaa tattacgatg     1620

atgtcgaagt cgatgcctgg caaggcggcg tatcactcta tactggcccg gtgatcacca     1680

gctaccgcta tacccattat gactccagcg atgcaggtgg tagttatagc aatatgattt     1740

ccgtgcgtct gaatgacccg cgcggcactg gttatacgca actatggcta agccgcggaa     1800

caggcgctta cacctatgac tggacgccag aaacacgcta cggcagcatg aagagcgtca     1860

gtctgcaacg tattcaaccg ctgactgagc aacttaatct cgggctgacg gcaggtaaag     1920

tgtggtacga caccccaacc gatgattata acggtctgca acttgcagcc catctgacct     1980

ggaaattctg attccttctg ccgcccgcta tccggggcgg ccttccctgc cgattagccc     2040

ccccctttcc tctttgtttt ccgaccacat tcaccggata aattttattc tccagtgtta     2100

tatactatag gggggtatgc attgacatat agcatacccc cctatagtat attgcgtgca     2160

gataatgagg tgcgaaatgc ccagtactcc ggaagagaag aaaaaggtcc ttactcgagt     2220

tcgtcgtatt cgagggcaga ttgatgctct ggaacggtcg ctggagggtg atgccgaatg     2280

ccgtgccata ctccaacaga tcgctgccgt tcggggcgcg gctaatgggc tgatggcaga     2340

agtgcttgaa agccatatcc gggaaacgtt tgaccgaaat gactgctaca gccgcgaagt     2400

cagccaatcc gttgacgaca ctattgaact ggttcgagcc tatcttaaat agctgaatct     2460

attaccatat tgaggaagag cgagagatga aatcacgtgc tgccgttgca tttgctcccg     2520

gtaaaccgct ggaaatcgtt gaaattgacg ttgcaccacc gaaaaaaggt gaagtgctga     2580

ttaaagtcac ccataccggc gtttgccata ccgacgcatt taccctctcc ggggatgacc     2640

cggaaggtgt attcccggtg gttctcggtc acgaaggggc cggcgttgtg gttgaagtcg     2700

gtgaaggcgt aaccagcgtc aaacctggcg accatgtgat cccgctttac accgcggagt     2760

gcggcgagtg tgagttctgt cgttctggca aaactaacct ctgtgttgcg gttcgcgaaa     2820

cccagggtaa aggcttgatg ccagacggca ccacccgttt ttcttacaac gggcagccgc     2880

tttatcacta catgggatgc tcaacattca gtgaatacac cgtggtcgcg gaagtgtctc     2940

tggccaaaat taatccagaa gcaaaccatg aacacgtctg cctgctgggc tgtggcgtga     3000

ccaccggtat tggcgcggtg cacaacacag ctaaagtcca gccaggtgat tctgttgccg     3060

tgtttggtct tggcgcgatt ggtctggcag tggttcaggg cgcgcgtcag gcgaaagcgg     3120

gacggattat cgctatcgat accaacccga agaaattcga tctggctcgt cgcttcggtg     3180

ctaccgactg cattaacccg aatgactacg acaaaccgat taaagatgtc ctgctggata     3240

tcaacaaatg gggtatcgac catacctttg aatgcatcgg taacgtcaac gtgatgcgtg     3300

cggcgctgga aagtgcgcac cgcggctggg gtcagtcggt gatcatcggg gtagcaggtg     3360

ccggtcagga aatctccacc cgaccattcc agttggtcac cggtcgcgta tggaaaggtt     3420

ccgcgtttgg cggcgtgaaa ggtcgttccc agttaccggg tatggttgaa gatgcgatga     3480

aaggtgatat cgatctggaa ccgtttgtca cgcataccat gagccttgat gaaattaatg     3540

acgccttcga cctgatgcat gaaggcaaat ccattcgaac cgtaattcgt tactgatttc     3600

ccgcaggtat accccgtcca cttcagacgg ggttcttaat actctccctg ggcagccgtc     3660

cgggggatta accgtgagat aatgactgat ggaactcatt gaaaaacatg ccagctttgg     3720

cggctggcaa aatgtgtatc ggcattattc ccaatcactg aaatgtgaaa tgaatgtcgg     3780

cgtctatctc ccaccaaaag ccgcgaatga aaaattgccg gtgttgtact ggctttcagg     3840

cctgacttgc aacgagcaga atttcattac taaatcgggg atgcagcgtt acgcggctga     3900

gcacaacatt attgttgttg cgccggacac cagtccgcga ggcagtcatg tcgcagatgc     3960

tgaccgttac gatctcgggc aaggtgccgg gttttacctg aacgcgacgc aagcgccgtg     4020

gaatgaacat tacaaaatgt atgactatat ccgcaacgag ctgccggatt tagtgatgca     4080

tcattttccg gcaacggcca aaaagtctat ctctggtcat tctatgggcg ggctgggcgc     4140

gctggtgctg gcgttacgta acccagatga atatgtcagc gtctcggcgt tttcgcccat     4200

tgtctcccca tcgcaagtgc cgtggggaca gcaagccttt gctgcatatc ttgctgaaaa     4260

taaagatgcc tggttggatt acgacccggt gagtcttatt tcacaaggtc aacgcgttgc     4320

ggaaatcatg gttgatcagg ggttgagtga tgatttttac gcagaacagc tgcggactcc     4380

aaatcttgaa aagatctgcc aggagatgaa tatcaagacg ttaatccgtt atcacgaggg     4440

ttatgatcac agctattatt ttgtctccag ttttattggc gagcatattg cctaccacgc     4500

caataaactg aatatgcgtt gataatagtg cacgactgcc ggatgcggcg tgaacgcctt     4560

atccggccta cacttcgccc gtaaaccgta ggcctgataa gacgcgcaaa gcgtcgcatc     4620

aggcatggcg cacgactgcc ggatgcggcg tgaacgcctt atccggtcta cacttcgccc     4680

ataaaccgta ggcctgataa gacgcgcata gcgtcgcatc aggcatctgc gcacgactta     4740

tctatgttta ccacatcaaa tcatcaggca ctttgaagtc ggcatacggg tcgtcttcat     4800

cctgctcttc ggcgctgagc gcgctgtgca acactatact gctggcatcg cgctgagcaa     4860

ttttatcggc aacgctggcg ggaataatgg cgtattcacc ttcgctattg ttatcgacca     4920

acaagcgggc aatcgccaga cgaccattaa tcaactgcgc ctgtgtgagc ttatcgacaa     4980

aaatcttctt aatcagattg ccgtcagtga agttaaaacc aatatcgcca ttggcaatgg     5040

tgattcggtt catttcaata agctgcttca cctgagcttt atattctttc gccaacgccg     5100

cttgtttttg ctgttcgcta agctgtttat cacgctcaag ctgtgccttt ttattttctt     5160

ctaccgccgc ccgagcttca cgcgcctgaa cgcgcgattt tttcgccgtt ctctccacct     5220

tcgccgcttt tttgctggtg actaatcctg ctttgagcaa ctgctcttgt aaggtaagtt     5280

ttgccatctt tgtttccaaa cccgctgaat aatttttagc gagtatacct gtaaacgccg     5340

taggtgtatt ggggtgaagt ccctttcgcc cctgcctaat aaggcacgtc aggcatcggc     5400

gcacggctgt attcgtgatc tccggctcat caaaataaac accgccaacc cagcaacaag     5460

aatacccggt gcagaagcgg ccattacgcc gaccgtgcca gtgcctaatg ccagcatttt     5520

cccggccagt aacggaccgc tcatagcccc cagacgccct accgccacgg ctgttcccac     5580

acctgttgcg cggatctgcg aactgtaaaa caacggtgcc agggcataca aaacgctttg     5640

cccacctgtc gcaaacaacc ccgcgacaaa tcccgccagc aacataccgt taaatgacga     5700

caccgttcca agcgccagca gcgaagctaa catgccgcta taaatcagta gcgacatggt     5760

tactggacgc agcttatcca tcaatgcgcc caacattaac gtcccgcttg ccgcccccat     5820

ttgcagggca aacatcaccc ctgccgcctg cgatggctgg aatccttgct ccaccaaaag     5880

tagcggtagc cagttgatca acatgtagac caccagcaga gtgaagaaat aacacaacca     5940

cagcagcagc gtcgcggttg ccgtttctgg cgcaaataag gcacgcagtg gtggcgcaga     6000

ctgtttttcg ccagcgaaaa ccgccgactc cggcagccag cgcattaata gcggcaccag     6060

aatcaacggc accacaccac ctacccaaaa caccgtttgc catgctaagt ttgcccccgc     6120

gaaacccagt gtcgccgcca gcgccgcgcc aatgggaaca ccgcaataca tcaggctcac     6180

tgccgtccca cgaaaacgtg gacccgcggc ttcagacgtc agggcgataa gattcggcaa     6240

cgccgccccc agcccgacac cggtcatcag ccgcgcaaag accagtgagg ggaaatccca     6300

ggcaatcgcc gttgccagtg agaacaaacc aaacagcgca actgagccaa tcaaaatacg     6360

cttacgacca taacggtccg ccagcattcc gccaaccaac gcgccgggta gcaaaccgag     6420

tattccggcg ctaaatatcc agcccatttg cattttatcg agtgcgaaag cctgggcgat     6480

gccacccgcc gcaatgccag ccgcctgaag atccagccct tccatcagag cgaccaaaaa     6540

acaaagcccg atggtcagca tcaggcggga tgaagatgat gaaggggtac gagtcgacat     6600

aagatgaacc tcattgcgag tgcaggtgaa tcgcgactga tacattgcca gccgcgtaat     6660

cagaactatt gaatgactgc ctacgggcga aatgtaggcc ggataaggcg ttcacgccgc     6720

atccggcagt cgtgtgcaga tgcctgatgc gacgcttgcg cgtcttatca ggcctacaaa     6780

ttcccgcgcc atccgtaggc cggataaggc gtttacgccg catccggcag tcgtgcgcag     6840

atgcctgatg cgacgctaac gcgtcttatc aggcctacaa attctcgcgc catccgtagg     6900

ccggacaaga cgttcacgcc gcatccggca gtcgtgctgg gatgggcata caaaatgcac     6960

attctcggca gtcaatatta tttgttgttg cgcagatcca gcgccacgtc gacgatcata     7020

tcctcctggc cgccaaccat ccggcgtttg cccagctcaa cgagaatatc caccgcgctt     7080

aagccataac gcgccgccgc cgtttcacag tgacgcagga agctggagta aacaccagcg     7140

tatcccagcg ccagcgtttc gcgatcgact cgtaccggtc gatcctgcaa cggacgcacc     7200

aggtcgtcag cggcatccat taacgcatag agatcggtcc catgctgcca gcccagttta     7260

tccgcggcgg caataaatac ttccagcggc gcgttacctg cgcccgcgcc cattcccgcg     7320

aggctggcgt cgattcggtc gcagccctct tccaccgcct cgatagagtt cgccacgcca     7380

agactcaggt tatggtgagc gtgcatgccg gtttgcgttt ctggtttcaa cactgctttc     7440

agggcgcgga aacggtcacg gatatcgctc atgttcatcg caccgccaga atccaccaca     7500

taaatacagg tcgcaccgta gccttccatc agctttgcct gctttgcgag attctctggc     7560

gtggtcatat ggctcatcat cagaaaacca acggtgtcca ttccgagctc gcgggcatac     7620

tgaatatgct gggcggaaac atcagcttcg gtacagtgcg tagccacacg aaccacccgc     7680

gcgccagctt gccaggcatt tttcagatcg tgaatagtgc cgattcctgg cagcaacaac     7740

gtcgcgattt tggcgtgctt caccacatcc gccgctgctt caatccattc aaggtcgcta     7800

tgtgcgccga aaccatagtt aaagctggaa ccctgcaaac cgtcgccgtg ggccacttca     7860

atcgaatcca cgtgggcatc gtccagtgct ttggcaatct ggcgaacgtt ttccagcgaa     7920

tactgatgac gaatggcgtg cataccgtca cgcaacgtga cgtccgagat ataaagtttt     7980

ttaccgttca tgccgcttct cctgccttgc gcgccagtga ctgggccatt ttttccgctg     8040

tcgccagcgc actggaagtc ataatgtcga ggttgcccgc ataggcaggc agataatgcg     8100

ctgcgccttc gacttccagc cagaccgctg ttttcagtcc ggagaattgc cccacgcccg     8160

gtaaattgac cggtttatcc tgcgggataa cttcaaactg cacgcgctgt ttcaggcgat     8220

aacccggtac gtaagcctgc accgcctcag ccatttcatt gattgaggct tcgatatcat     8280

cttgtgaagc ttcgtcgctc aatacataca ccgtgtcacg catcatcaac ggtggctctg     8340

ctgggttaag cacaataatc gccttccctt ttgccgcgcc gcccaccact tcaatggctc     8400

gggaagtggt ttccgtaaat tcatcgatat tggcacgcgt gccaggtccg gcagatttac     8460

tggcgataga agcgataatt tcggcgtaat gaacacgcgc cacgcgtgaa actgccgcca     8520

ccattggaat ggtggcctgg ccgccgcagg tgaccatgtt gacgttcagt tgatcgacgt     8580

tcgcctcgag gttaaccacc ggcacgcagt aagggccgat ggcagcaggc gtcaggtcaa     8640

ttaagcgaat atccggtttc gcttcgcgta aagcggcatc gtttttcaca tgagcaccgg     8700

cgctggtcgc atcaaataca atgtcgatat cagcaaattc aggcatgttc atcagtccga     8760

tcaccccttc atgggtggtg gcgacgccca tacgtctggc gcgcgccaga ccgtcggact     8820

gaggatcaat gccaaccatc accgccatct ccagatgctg accgtgacgc aaaattttaa     8880

tcatcagatc ggtgccaatg ttgccagaac cgataatggc gactttacgc ttactcatga     8940

cagacttcct tttggggctg cgcttgaaaa tgtcgcagca actgaaccta tgccttcaat     9000

atgggcttca aaacgatcgc ccgcattcac cgccaccatc ggacctaatg ccccggtaag     9060

aatgatatct ccggtgcgca gcggttcacc cagactggcc attttgcgtg ccagccagac     9120

ggccgcatta agcggatgtc ccaggcattc gctgccgcgc ccgctagaaa cctcttcgtt     9180

attacgcgtc atcttcatgg cgcagttttt caggtctaac cccgccggac gttgcgccgg     9240

accgccgatg acatacaccc cacaggaggc gttatctgcc acggtatcga caaactgaat     9300

cgaccagtcg cgaatgcggc tccccaccac ttccagcgcc ggaagtaccc attcaatggc     9360

gttatacaat tcgtcgaagg tgatatcggt tgcgggcaaa tcgcggttca acaccagtgc     9420

gatctccgct tcaatgcggg gttgcagaac acgggaaaaa ggaatgattt cgttatcgcc     9480

ataacacatg tcggcaaata atgtcccgaa atccggttga tcaacgccca gttgttgctg     9540

cactttcgga tgcgtcaggc ccactttacg ccctaccacg cgacgcccct gcgcaacgtc     9600

atattgcaca tttatgtgct gaatggcgta ggccgcttca gcgttatcga taccaatcag     9660

atcgcgcagc ggcgcaatcg cttcgccctg ctctgcggcg cggcgtaaat ccgccgccag     9720

ttgctcaaga gtatgcttcg tcatgaccat tccttaaggg cgtgcgagga aattcagcac     9780

caattgattg aaagcgtcgg catgttccca ctgcgcccag tgaccacagt cgcggaagat     9840

atgcagttca gaaccggcaa tgccggacag cagacgcaga cccgcatcca tcggcacaaa     9900

gcggtcgttg cgcccccaga caatcagggt ttgcgctttg atttccgcca gacgtgggcc     9960

aaaatccggg aactgtttcg gattagcttc caggctctta acgaagtttt ccaggtgatc    10020

gcggcgcgac agcatattat tcaggcgcgc ttcaaacagg gcgtcggtca aatcgctggt    10080

atcgaaaacg aagatatcca tcatcagctt caggttttcg atagtcggct gacgataaag    10140

ctgattcagt cgcttaatac cttcggttgg catcggcgta aacaaactca tgccgcccgt    10200

accgccgccc atcagcacca gtttgccgac gcgctccggc cagttaaggg tgaacgccac    10260

agaactatgg ccgcccatcg agttgcccag caggtggatt ttggcgatat ccagttgatc    10320

caccacgctt ttcaggattc gtgcattaag atccgatcgt gaaccactat taacgatcga    10380

atcgcttttg ccccaacccg gacaatccag caggatcacc cgatagcccg cctctaccag    10440

cggatcgata ttgcggctga agttcgccca gccagtagca cccgggccgg aaccatgcag    10500

caggacaacg gtttcgtcgc cttgtccgca gtcattaaaa tggatgcgca gcgttttacc    10560

cgcttcttct acattcagaa aacggctggt ggcggcttcg gtttgtggct gataactcat    10620

catcttctcc tgcatattca gttctctgtt ctggcgctta acgagccaaa tccggcaatc    10680

cactccggga ttgggcggta ataacgccct tcgctacgcc agttgccaaa tgcagaaata    10740

gcggcaaaag cggcgaccca ggttttgatt tcatgtgtcg actttccggc aatggcggaa    10800

agctcttcgt tactgacggc atccagttcc tgtatgcgtc cctgctccag caaagtcatg    10860

aactggttat cccaaatcgg gttgagcgga tgcagagttc tctgatcctc aacaaacttc    10920

tcagcggcgc taatcacccg ttgctgacgc aattcgcgct cactggcggg taaatctttc    10980

ccgctcccca acagacggtc gcgcatatgg gcatcggctt tcgccagttc gggcaccggc    11040

ggctgatggg aaagcccacc ggaacccagg aacagcacgc gtttattgag agtgctggtg    11100

aaacgtccaa tggcttcacc caacatgcgg gtacgctgga aaccgggcag cggcgtggcg    11160

acaccgttga tgaacacagg cagaactggc accttatcca gcccgccgag caggaactcc    11220

agtggctggg cgaacccgtg gtccacctgc atacagtaag aaacggcaag atcgatcccg    11280

ctcttcatga cggcatgcgc acaggcctcc gccagctcca caggcacggg cagctctcct    11340

gccgcactgc cgaaatcacc aattgccgtc gccccaacgc ctaaacagaa cggtggcatc    11400

acgtcataga aaaagccgtt gtagtgatct ggcgcaaaca gcaccaccag ttcaggggag    11460

aaagccgcaa tacgctcgcg ggcgctggca atcacgccat tgacctcatc gagtacctct    11520

tgcgccgggt cgacatatcc caccagcggc gagtgggaaa gacagtgaag ataagcgtgc    11580

atatcaggct accttttcga cagaaacgtc ggcatcaggg cgggtcagcg tcatcaccga    11640

cgccagttta ttcagcgtat tacccagggt ttgcggaatg gcggtggcgg caacaaagcg    11700

atccgggcgc atcaccacca gcgaagcatt atgttgtgcg aaccagctac gcaggcgacc    11760

ttgcgtatcc cccacgcgta gtacgccgtc gtggttatcc tgtgcggtat gaatttgcac    11820

ttccggcacc acctgaatga agcgggtgcc caacgcgcgc cactgctgga tttgctcgtc    11880

gctcatcccc cacagtggat tgcatcccca gccaattacc gcgaagttcg cgccgatcgc    11940

gttatcgagc agcgtcacgt cgccgttttc cagcgtgact ttcggctgaa taaacatctt    12000

gccgaccgga gagtgcttcg cttcgccctc tcgcaccagc gcaccgccgt aatattgcgg    12060

catcggcttg aagcgcattt cgaggaagta gcgttttact ggcggcagat aattcaacag    12120

ccaggaaacg ccgtcacgta acgtaccctg ccagcgtttc ggcggagcca gcacgttgcc    12180

cgccgtcacg gacaggtcaa tcatcgcttt ggcgtgatcg cgtcgttctt gttgataggt    12240

atcgagcagc gcatcacggg ctttcccctg gataaccaac gccagtttcc aggcgaggtt    12300

aaaggcgtcg cgcataccgc tgttatagcc ctgcccctgc cataccggca tgatgtgcgc    12360

ggcatcgccc gccagcagta cgcgatcaat acggaaacgt tgcgccagtc gcgcgttgtg    12420

ggtgtagaca cgctggcgaa tcaattcaac attgtccgga ttaggcagca ctttgcttaa    12480

cagcttgcgc atattttgcg gctcacgcag ctgttcttcg gtttctcctg gcatcaccat    12540

aaattcaaag cgacgtaccg catgaggtag cgcggcagaa acatacgggc gcaccggatc    12600

gcaacacaaa tagatatgcg gcgtacttaa cggatcgttg gcgatatcta ccacaatcca    12660

ctgatttggc gcagttttac cttcaaacgg cacattcagg gtgcgacgga caaaacttgc    12720

cccaccatca caggccacca gccactgggc tttgactatt tcccgctgcc cttctgccgt    12780

tttcaggtgc aaggtcactt cgtcatcttg ctgactgaag gcctccagct cgcgggaaaa    12840

caagcagcgc acattcggaa aacgcgacac cccttccagc atcaccgcat cgacctgcgg    12900

ctgaataaag gcgttacggc gcggccagcc aaattcatcg gtcattggct gaatatcagc    12960

aaaacagcgg cctttcgggg tgagaaaacg catcgcgtgc cacggcgtag tgtgcggcag    13020

aacatcatcg accaggccga ccgactgcat ggtgcgcagc gcctcgtcat caataccaat    13080

cgcacgcggg tagtcgatca acttatcgag tttctccacc accagcacgt caatgcccat    13140

ctggccgaga tagttcgcca tcatcagccc aaccgggccg gcaccagcga tcgccacctg    13200

aacgctatgg ttaacagcag gctggatgtc agggtgttgt attgccattt cagtacctca    13260

cgactcggac aaaatgtcgt tgcgcgcaca gtacagcgca acttattttg ttaaaaacat    13320

gtaaatgatt ttttattgtg cgctcagtat aggaagggtg ttttcggcta caatcaaaac    13380

atgcccgaat gtgcaccagg tgcaccacgt tgttttaact atagaaatgt caattaatat    13440

gcagaacaat gagcagacgg aatacaaaac cgtgcgcggc ttaacccgcg gtctaatgtt    13500

attaaatatg ttaaataaac ttgatggcgg tgccagcgtc gggctgctgg cggaactcag    13560

cggcctgcat cgcaccactg tgcggcgact gctggagacg ctgcaggaag agggatatgt    13620

ccgccgtagc ccctccgatg atagttttcg actgaccatc aaagtgcggc aattaagcga    13680

aggatttcgt gacgaacagt ggatttctgc actggcggcc ccactgctgg gcgatctgtt    13740

gcgcgaagtg gtatggccga cagatgtgtc cacgctggat gttgatgcaa tggtggtacg    13800

cgaaaccact caccgtttca gccgcttatc ctttcaccgg gcaatggtcg ggcgacgttt    13860

gccgcttctg aaaaccgcct cgggcctgac ctggctggcc ttttgcccgg aacaagaccg    13920

caaggaatta atcgaaatgt tagcctcccg ccccggtgat gactatcaac tggcacggga    13980

accgttaaag ctggaagcca ttctggcgcg cgcgcgcaaa gagggttacg gacagaacta    14040

ccgcggctgg gatcaggagg agaagatcgc ctctatcgcc gtaccgctgc gcagtgaaca    14100

acgggtgatt ggctgtctga atctggtgta tatggcgagc gcaatgacca ttgaacaggc    14160

agcggaaaag catcttccgg cgctacaacg ggtagcaaaa cagatcgaag aaggggttga    14220

atcgcaggct attctggtgg ccggaaggcg aagcggcatg catttacgtt gacaccatcg    14280

aatggcgcaa aacctttcgc ggtatggcat gatagcgccc ggaagagagt caattcaggg    14340

tggtgaatgt gaaaccagta acgttatacg atgtcgcaga gtatgccggt gtctcttatc    14400

agaccgtttc ccgcgtggtg aaccaggcca gccacgtttc tgcgaaaacg cgggaaaaag    14460

tggaagcggc gatggcggag ctgaattaca ttcccaaccg cgtggcacaa caactggcgg    14520

gcaaacagtc gttgctgatt ggcgttgcca cctccagtct ggccctgcac gcgccgtcgc    14580

aaattgtcgc ggcgattaaa tctcgcgccg atcaactggg tgccagcgtg gtggtgtcga    14640

tggtagaacg aagcggcgtc gaagcctgta aagcggcggt gcacaatctt ctcgcgcaac    14700

gcgtcagtgg gctgatcatt aactatccgc tggatgacca ggatgccatt gctgtggaag    14760

ctgcctgcac taatgttccg gcgttatttc ttgatgtctc tgaccagaca cccatcaaca    14820

gtattatttt ctcccatgaa gacggtacgc gactgggcgt ggagcatctg gtcgcattgg    14880

gtcaccagca aatcgcgctg ttagcgggcc cattaagttc tgtctcggcg cgtctgcgtc    14940

tggctggctg gcataaatat ctcactcgca atcaaattca gccgatagcg gaacgggaag    15000

gcgactggag tgccatgtcc ggttttcaac aaaccatgca aatgctgaat gagggcatcg    15060

ttcccactgc gatgctggtt gccaacgatc agatggcgct gggcgcaatg cgcgccatta    15120

ccgagtccgg gctgcgcgtt ggtgcggata tctcggtagt gggatacgac gataccgaag    15180

acagctcatg ttatatcccg ccgttaacca ccatcaaaca ggattttcgc ctgctggggc    15240

aaaccagcgt ggaccgcttg ctgcaactct ctcagggcca ggcggtgaag ggcaatcagc    15300

tgttgcccgt ctcactggtg aaaagaaaaa ccaccctggc gcccaatacg caaaccgcct    15360

ctccccgcgc gttggccgat tcattaatgc agctggcacg acaggtttcc cgactggaaa    15420

gcgggcagtg agcgcaacgc aattaatgta actaggcacc ccaggcttta cactttatgc    15480

ttccggctgg tataatgtgt ggacctgtag aaataatttt gtttaacttt aataaggaga    15540

tataccatgg gaggcagtac tgttgcacca actacaccgt tggcaaccgg cggtgcgctc    15600

cgcaaagtgc gacaagccgt ctttcccatc tacggaaacc aagaagtcac caaatttctg    15660

ctcatcggat ccattaaatt ctttataatc ttggcactca cgctcacgcg tgataccaag    15720

gacacgttga ttgtcacgca atgtggtgcc gaagcgattg cctttctcaa aatatacggg    15780

gtgctacccg cagcgaccgc atttatcgcg ctctattcca aaatgtccaa cgccatgggc    15840

aaaaaaatgc tattttattc cacttgcatt cctttcttta cctttttcgg gctgtttgat    15900

gttttcattt acccgaacgc ggagcgactg caccctagtt tggaagccgt gcaggcaatt    15960

ctcccgggcg gtgccgcatc tggcggcatg gcggttctgg ccaagattgc gacacactgg    16020

acatcggcct tattttacgt catggcggaa atatattctt ccgtatcggt ggggctattg    16080

ttttggcagt ttgcgaacga cgtcgtcaac gtggatcagg ccaagcgctt ttatccatta    16140

tttgctcaaa tgagtggcct cgctccagtt ttagcgggcc agtatgtggt acggtttgcc    16200

agcaaagcgg tcaactttga ggcatccatg catcgactca cggcggccgt aacatttgct    16260

ggtattatga tttgcatctt ttaccaactc agttcgtcat atgtggagcg aacggaatca    16320

gcaaagccag cggcagataa cgagcagtct atcaaaccga aaaagaagaa acccaaaatg    16380

tccatggttg aatcggggaa atttctcgcg tcaagtcagt acctgcgtct aattgccatg    16440

ctggtgctgg gatacggcct cagtattaac tttaccgaaa tcatgtggaa aagcttggtg    16500

aagaaacaat atccagaccc gctagattat caacgattta tgggtaactt ctcgtcagcg    16560

gttggtttga gcacatgcat tgttattttc ttcggtgtgc acgtgatccg tttgttgggg    16620

tggaaagtcg gagcgttggc tacacctggg atcatggcca ttctagcgtt accctttttt    16680

gcttgcattt tgttgggttt ggatagtcca gcacgattgg agatcgccgt aatctttgga    16740

acaattcaga gtttgctgag caaaacctcc aagtatgccc ttttcgaccc taccacacaa    16800

atggcttata ttcctctgga cgacgaatca aaggtcaaag gaaaagcggc aattgatgtt    16860

ttgggatcgc ggattggcaa gagtggaggc tcactgatcc agcagggctt ggtctttgtt    16920

tttggaaata tcattaatgc cgcacctgta gtaggggttg tctactacag tgtccttgtt    16980

gcgtggatga gcgcagctgg ccgactaagt gggctttttc aagcacaaac agaaatggat    17040

aaggccgaca aaatggaggc aaagaccaac aaagaaaagt agttaaccta ggctgctgcc    17100

accgctgagc aataagactc ctgttgatag atccagtaat gacctcagaa ctccatctgg    17160

atttgttcag aacgctcggt tgccgccggg cgttttttat tggtgagaat               17210


<210> 5
<211> 17898
<212> DNA
<213> Escherichia coli

<400> 5
ttattgcacg aagcgcgagg taacgtactg gctgtaatca ttcgctacag ccgggacctt       60

gccctgctct ttcaaaaact gcgcggtgtc gatgatcgct ttgttcaccg gtccggtcag      120

ttctgccgtt tgttgctgcg gcgtcagata ggtattcccc ttcaccagcc ccggaacgtc      180

accttcaggc acgccgctta accgcgccag tttgctgatg ttttccggct gtttcagcca      240

cgcgtctggg ttagcaatgt acggttgctg agcatcgatg gcgcttttgg cgaacgcttt      300

caccacctca ggatgtttct cggcaaaatc tttgcgcacc acccagacgt ccagcgttgg      360

cgcaccccac tgcccgacct gttcagaatc ggtcagcact ttgccgtctt tttccagggc      420

gttaaccgcc ggtgcccaga cataagcacc atcaatatct ccccgctgcc atgcagcgat      480

aatcgcgggc ggctgcaggt tcacaatctc cacttgccca ggtttaatgc cccagtgttt      540

cagcgctgcc agcaggctgt agtgggtggt agagataaac ggtacggcga tgcgtttgcc      600

aatcagatct tccggtttgc tgatagtttt ctttaccacc agcgcttctg agttacccag      660

ttttgacgcc agcaagaaga cttcaatcgg cacctgttgg ctggctgcaa ccgctaacgg      720

gctggaacca aggttgccga tttgcacgtc gccagaagcc agcgcccgca cgatgctggc      780

tccgctgtca aacttacgcc agtccacggt tgctccgctt tctttagcaa aggtgttgtc      840

ggcctgagcc actttcgccg gttcggctga ggtttgatac gccacggtga cgttcaccgc      900

ctgtgcctga aaagcgatga atgccagtgc ggcaagaagt gtgtttcgcg atgaaattgc      960

catgattgtc tgctcccctg tcttgttatg ggagcagtat tcaggaataa aaacattcat     1020

taaaagaatt agtcgttatc gcacagatga ttttattctt agcaaaaaaa cggtgatgct     1080

gccaacttac tgatttagtg tatgatggtg tttttgaggt gctccagtgg cttctgtttc     1140

tatcagctgt ccctcctgtt cagctactga cggggtggtg cgtaacggca aaagcaccgc     1200

cggacatcag cgctatctct gctctcactg ccgtaaaaca tggcaactgc agttcactta     1260

caccgcttct caacccggta cgcaccagaa aatcattgat atggccatga atggcgttgg     1320

atgccgggca actgcccgca ttatgggcgt tggcctcaac acgattttac gtcacttaaa     1380

aaactcaggc cgcagtcggt aacctcgcgc atacagccgg gcagtgacgt catcgtctgc     1440

gcggaaatgg acgaacagtg gggctatgtc ggggctaaat cgcgccagcg ctggctgttt     1500

tacgcgtatg acaggctccg gaagacggtt gttgcgcacg tattcggtga acgcactatg     1560

gcgacgctgg ggcgtcttat gagcctgatg tcaccctttg acgtggtgat atggatgacg     1620

gatggctggc cgctgtatga atcccgcctg aagggaaagc tgcacgtaat cagcaagcga     1680

tatacgcagc gaattgagcg gcataacctg aatctgaggc agcacctggc acggctggga     1740

cggaagtcgc tgtcgttctc aaaatcggtg gagctgcatg acaaagtcat cgggcattat     1800

ctgaacataa aacactatca ataagttgga gtcattacct agaacgtaat ttacctgccg     1860

gaacttattc actccgacaa gaacttatcc gtacaggaga ttaaaatgat aaaacggacg     1920

ttattagcgg cggccatttt tagcgcattg cccgcttatg ccgggttaac ttccattacc     1980

gcgggctacg attttaccga ttattctggc gatcatggca accgtaattt agcgtatgct     2040

gaactggtgg cgaaagttga aaacgcaacg ctgcttttta atctttccca ggggcgtcgt     2100

gattatgaaa ctgaacattt caatgccact cgcggtcagg gtgcggtctg gtataaatgg     2160

aataactggc tgacaacccg aacgggtatt gcctttgcgg ataatacgcc ggtctttgcc     2220

cgccaggatt ttcgtcagga tattaacctg gccctgttgc caaaaacgct tttcacgacc     2280

ggttatcgct acactaaata ttacgatgat gtcgaagtcg atgcctggca aggcggcgta     2340

tcactctata ctggcccggt gatcaccagc taccgctata cccattatga ctccagcgat     2400

gcaggtggta gttatagcaa tatgatttcc gtgcgtctga atgacccgcg cggcactggt     2460

tatacgcaac tatggctaag ccgcggaaca ggcgcttaca cctatgactg gacgccagaa     2520

acacgctacg gcagcatgaa gagcgtcagt ctgcaacgta ttcaaccgct gactgagcaa     2580

cttaatctcg ggctgacggc aggtaaagtg tggtacgaca ccccaaccga tgattataac     2640

ggtctgcaac ttgcagccca tctgacctgg aaattctgat tccttctgcc gcccgctatc     2700

cggggcggcc ttccctgccg attagccccc ccctttcctc tttgttttcc gaccacattc     2760

accggataaa ttttattctc cagtgttata tactataggg gggtatgcat tgacatatag     2820

catacccccc tatagtatat tgcgtgcaga taatgaggtg cgaaatgccc agtactccgg     2880

aagagaagaa aaaggtcctt actcgagttc gtcgtattcg agggcagatt gatgctctgg     2940

aacggtcgct ggagggtgat gccgaatgcc gtgccatact ccaacagatc gctgccgttc     3000

ggggcgcggc taatgggctg atggcagaag tgcttgaaag ccatatccgg gaaacgtttg     3060

accgaaatga ctgctacagc cgcgaagtca gccaatccgt tgacgacact attgaactgg     3120

ttcgagccta tcttaaatag ctgaatctat taccatattg aggaagagcg agagatgaaa     3180

tcacgtgctg ccgttgcatt tgctcccggt aaaccgctgg aaatcgttga aattgacgtt     3240

gcaccaccga aaaaaggtga agtgctgatt aaagtcaccc ataccggcgt ttgccatacc     3300

gacgcattta ccctctccgg ggatgacccg gaaggtgtat tcccggtggt tctcggtcac     3360

gaaggggccg gcgttgtggt tgaagtcggt gaaggcgtaa ccagcgtcaa acctggcgac     3420

catgtgatcc cgctttacac cgcggagtgc ggcgagtgtg agttctgtcg ttctggcaaa     3480

actaacctct gtgttgcggt tcgcgaaacc cagggtaaag gcttgatgcc agacggcacc     3540

acccgttttt cttacaacgg gcagccgctt tatcactaca tgggatgctc aacattcagt     3600

gaatacaccg tggtcgcgga agtgtctctg gccaaaatta atccagaagc aaaccatgaa     3660

cacgtctgcc tgctgggctg tggcgtgacc accggtattg gcgcggtgca caacacagct     3720

aaagtccagc caggtgattc tgttgccgtg tttggtcttg gcgcgattgg tctggcagtg     3780

gttcagggcg cgcgtcaggc gaaagcggga cggattatcg ctatcgatac caacccgaag     3840

aaattcgatc tggctcgtcg cttcggtgct accgactgca ttaacccgaa tgactacgac     3900

aaaccgatta aagatgtcct gctggatatc aacaaatggg gtatcgacca tacctttgaa     3960

tgcatcggta acgtcaacgt gatgcgtgcg gcgctggaaa gtgcgcaccg cggctggggt     4020

cagtcggtga tcatcggggt agcaggtgcc ggtcaggaaa tctccacccg accattccag     4080

ttggtcaccg gtcgcgtatg gaaaggttcc gcgtttggcg gcgtgaaagg tcgttcccag     4140

ttaccgggta tggttgaaga tgcgatgaaa ggtgatatcg atctggaacc gtttgtcacg     4200

cataccatga gccttgatga aattaatgac gccttcgacc tgatgcatga aggcaaatcc     4260

attcgaaccg taattcgtta ctgatttccc gcaggtatac cccgtccact tcagacgggg     4320

ttcttaatac tctccctggg cagccgtccg ggggattaac cgtgagataa tgactgatgg     4380

aactcattga aaaacatgcc agctttggcg gctggcaaaa tgtgtatcgg cattattccc     4440

aatcactgaa atgtgaaatg aatgtcggcg tctatctccc accaaaagcc gcgaatgaaa     4500

aattgccggt gttgtactgg ctttcaggcc tgacttgcaa cgagcagaat ttcattacta     4560

aatcggggat gcagcgttac gcggctgagc acaacattat tgttgttgcg ccggacacca     4620

gtccgcgagg cagtcatgtc gcagatgctg accgttacga tctcgggcaa ggtgccgggt     4680

tttacctgaa cgcgacgcaa gcgccgtgga atgaacatta caaaatgtat gactatatcc     4740

gcaacgagct gccggattta gtgatgcatc attttccggc aacggccaaa aagtctatct     4800

ctggtcattc tatgggcggg ctgggcgcgc tggtgctggc gttacgtaac ccagatgaat     4860

atgtcagcgt ctcggcgttt tcgcccattg tctccccatc gcaagtgccg tggggacagc     4920

aagcctttgc tgcatatctt gctgaaaata aagatgcctg gttggattac gacccggtga     4980

gtcttatttc acaaggtcaa cgcgttgcgg aaatcatggt tgatcagggg ttgagtgatg     5040

atttttacgc agaacagctg cggactccaa atcttgaaaa gatctgccag gagatgaata     5100

tcaagacgtt aatccgttat cacgagggtt atgatcacag ctattatttt gtctccagtt     5160

ttattggcga gcatattgcc taccacgcca ataaactgaa tatgcgttga taatagtgca     5220

cgactgccgg atgcggcgtg aacgccttat ccggcctaca cttcgcccgt aaaccgtagg     5280

cctgataaga cgcgcaaagc gtcgcatcag gcatggcgca cgactgccgg atgcggcgtg     5340

aacgccttat ccggtctaca cttcgcccat aaaccgtagg cctgataaga cgcgcatagc     5400

gtcgcatcag gcatctgcgc acgacttatc tatgtttacc acatcaaatc atcaggcact     5460

ttgaagtcgg catacgggtc gtcttcatcc tgctcttcgg cgctgagcgc gctgtgcaac     5520

actatactgc tggcatcgcg ctgagcaatt ttatcggcaa cgctggcggg aataatggcg     5580

tattcacctt cgctattgtt atcgaccaac aagcgggcaa tcgccagacg accattaatc     5640

aactgcgcct gtgtgagctt atcgacaaaa atcttcttaa tcagattgcc gtcagtgaag     5700

ttaaaaccaa tatcgccatt ggcaatggtg attcggttca tttcaataag ctgcttcacc     5760

tgagctttat attctttcgc caacgccgct tgtttttgct gttcgctaag ctgtttatca     5820

cgctcaagct gtgccttttt attttcttct accgccgccc gagcttcacg cgcctgaacg     5880

cgcgattttt tcgccgttct ctccaccttc gccgcttttt tgctggtgac taatcctgct     5940

ttgagcaact gctcttgtaa ggtaagtttt gccatctttg tttccaaacc cgctgaataa     6000

tttttagcga gtatacctgt aaacgccgta ggtgtattgg ggtgaagtcc ctttcgcccc     6060

tgcctaataa ggcacgtcag gcatcggcgc acggctgtat tcgtgatctc cggctcatca     6120

aaataaacac cgccaaccca gcaacaagaa tacccggtgc agaagcggcc attacgccga     6180

ccgtgccagt gcctaatgcc agcattttcc cggccagtaa cggaccgctc atagccccca     6240

gacgccctac cgccacggct gttcccacac ctgttgcgcg gatctgcgaa ctgtaaaaca     6300

acggtgccag ggcatacaaa acgctttgcc cacctgtcgc aaacaacccc gcgacaaatc     6360

ccgccagcaa cataccgtta aatgacgaca ccgttccaag cgccagcagc gaagctaaca     6420

tgccgctata aatcagtagc gacatggtta ctggacgcag cttatccatc aatgcgccca     6480

acattaacgt cccgcttgcc gcccccattt gcagggcaaa catcacccct gccgcctgcg     6540

atggctggaa tccttgctcc accaaaagta gcggtagcca gttgatcaac atgtagacca     6600

ccagcagagt gaagaaataa cacaaccaca gcagcagcgt cgcggttgcc gtttctggcg     6660

caaataaggc acgcagtggt ggcgcagact gtttttcgcc agcgaaaacc gccgactccg     6720

gcagccagcg cattaatagc ggcaccagaa tcaacggcac cacaccacct acccaaaaca     6780

ccgtttgcca tgctaagttt gcccccgcga aacccagtgt cgccgccagc gccgcgccaa     6840

tgggaacacc gcaatacatc aggctcactg ccgtcccacg aaaacgtgga cccgcggctt     6900

cagacgtcag ggcgataaga ttcggcaacg ccgcccccag cccgacaccg gtcatcagcc     6960

gcgcaaagac cagtgagggg aaatcccagg caatcgccgt tgccagtgag aacaaaccaa     7020

acagcgcaac tgagccaatc aaaatacgct tacgaccata acggtccgcc agcattccgc     7080

caaccaacgc gccgggtagc aaaccgagta ttccggcgct aaatatccag cccatttgca     7140

ttttatcgag tgcgaaagcc tgggcgatgc cacccgccgc aatgccagcc gcctgaagat     7200

ccagcccttc catcagagcg accaaaaaac aaagcccgat ggtcagcatc aggcgggatg     7260

aagatgatga aggggtacga gtcgacataa gatgaacctc attgcgagtg caggtgaatc     7320

gcgactgata cattgccagc cgcgtaatca gaactattga atgactgcct acgggcgaaa     7380

tgtaggccgg ataaggcgtt cacgccgcat ccggcagtcg tgtgcagatg cctgatgcga     7440

cgcttgcgcg tcttatcagg cctacaaatt cccgcgccat ccgtaggccg gataaggcgt     7500

ttacgccgca tccggcagtc gtgcgcagat gcctgatgcg acgctaacgc gtcttatcag     7560

gcctacaaat tctcgcgcca tccgtaggcc ggacaagacg ttcacgccgc atccggcagt     7620

cgtgctggga tgggcataca aaatgcacat tctcggcagt caatattatt tgttgttgcg     7680

cagatccagc gccacgtcga cgatcatatc ctcctggccg ccaaccatcc ggcgtttgcc     7740

cagctcaacg agaatatcca ccgcgcttaa gccataacgc gccgccgccg tttcacagtg     7800

acgcaggaag ctggagtaaa caccagcgta tcccagcgcc agcgtttcgc gatcgactcg     7860

taccggtcga tcctgcaacg gacgcaccag gtcgtcagcg gcatccatta acgcatagag     7920

atcggtccca tgctgccagc ccagtttatc cgcggcggca ataaatactt ccagcggcgc     7980

gttacctgcg cccgcgccca ttcccgcgag gctggcgtcg attcggtcgc agccctcttc     8040

caccgcctcg atagagttcg ccacgccaag actcaggtta tggtgagcgt gcatgccggt     8100

ttgcgtttct ggtttcaaca ctgctttcag ggcgcggaaa cggtcacgga tatcgctcat     8160

gttcatcgca ccgccagaat ccaccacata aatacaggtc gcaccgtagc cttccatcag     8220

ctttgcctgc tttgcgagat tctctggcgt ggtcatatgg ctcatcatca gaaaaccaac     8280

ggtgtccatt ccgagctcgc gggcatactg aatatgctgg gcggaaacat cagcttcggt     8340

acagtgcgta gccacacgaa ccacccgcgc gccagcttgc caggcatttt tcagatcgtg     8400

aatagtgccg attcctggca gcaacaacgt cgcgattttg gcgtgcttca ccacatccgc     8460

cgctgcttca atccattcaa ggtcgctatg tgcgccgaaa ccatagttaa agctggaacc     8520

ctgcaaaccg tcgccgtggg ccacttcaat cgaatccacg tgggcatcgt ccagtgcttt     8580

ggcaatctgg cgaacgtttt ccagcgaata ctgatgacga atggcgtgca taccgtcacg     8640

caacgtgacg tccgagatat aaagtttttt accgttcatg ccgcttctcc tgccttgcgc     8700

gccagtgact gggccatttt ttccgctgtc gccagcgcac tggaagtcat aatgtcgagg     8760

ttgcccgcat aggcaggcag ataatgcgct gcgccttcga cttccagcca gaccgctgtt     8820

ttcagtccgg agaattgccc cacgcccggt aaattgaccg gtttatcctg cgggataact     8880

tcaaactgca cgcgctgttt caggcgataa cccggtacgt aagcctgcac cgcctcagcc     8940

atttcattga ttgaggcttc gatatcatct tgtgaagctt cgtcgctcaa tacatacacc     9000

gtgtcacgca tcatcaacgg tggctctgct gggttaagca caataatcgc cttccctttt     9060

gccgcgccgc ccaccacttc aatggctcgg gaagtggttt ccgtaaattc atcgatattg     9120

gcacgcgtgc caggtccggc agatttactg gcgatagaag cgataatttc ggcgtaatga     9180

acacgcgcca cgcgtgaaac tgccgccacc attggaatgg tggcctggcc gccgcaggtg     9240

accatgttga cgttcagttg atcgacgttc gcctcgaggt taaccaccgg cacgcagtaa     9300

gggccgatgg cagcaggcgt caggtcaatt aagcgaatat ccggtttcgc ttcgcgtaaa     9360

gcggcatcgt ttttcacatg agcaccggcg ctggtcgcat caaatacaat gtcgatatca     9420

gcaaattcag gcatgttcat cagtccgatc accccttcat gggtggtggc gacgcccata     9480

cgtctggcgc gcgccagacc gtcggactga ggatcaatgc caaccatcac cgccatctcc     9540

agatgctgac cgtgacgcaa aattttaatc atcagatcgg tgccaatgtt gccagaaccg     9600

ataatggcga ctttacgctt actcatgaca gacttccttt tggggctgcg cttgaaaatg     9660

tcgcagcaac tgaacctatg ccttcaatat gggcttcaaa acgatcgccc gcattcaccg     9720

ccaccatcgg acctaatgcc ccggtaagaa tgatatctcc ggtgcgcagc ggttcaccca     9780

gactggccat tttgcgtgcc agccagacgg ccgcattaag cggatgtccc aggcattcgc     9840

tgccgcgccc gctagaaacc tcttcgttat tacgcgtcat cttcatggcg cagtttttca     9900

ggtctaaccc cgccggacgt tgcgccggac cgccgatgac atacacccca caggaggcgt     9960

tatctgccac ggtatcgaca aactgaatcg accagtcgcg aatgcggctc cccaccactt    10020

ccagcgccgg aagtacccat tcaatggcgt tatacaattc gtcgaaggtg atatcggttg    10080

cgggcaaatc gcggttcaac accagtgcga tctccgcttc aatgcggggt tgcagaacac    10140

gggaaaaagg aatgatttcg ttatcgccat aacacatgtc ggcaaataat gtcccgaaat    10200

ccggttgatc aacgcccagt tgttgctgca ctttcggatg cgtcaggccc actttacgcc    10260

ctaccacgcg acgcccctgc gcaacgtcat attgcacatt tatgtgctga atggcgtagg    10320

ccgcttcagc gttatcgata ccaatcagat cgcgcagcgg cgcaatcgct tcgccctgct    10380

ctgcggcgcg gcgtaaatcc gccgccagtt gctcaagagt atgcttcgtc atgaccattc    10440

cttaagggcg tgcgaggaaa ttcagcacca attgattgaa agcgtcggca tgttcccact    10500

gcgcccagtg accacagtcg cggaagatat gcagttcaga accggcaatg ccggacagca    10560

gacgcagacc cgcatccatc ggcacaaagc ggtcgttgcg cccccagaca atcagggttt    10620

gcgctttgat ttccgccaga cgtgggccaa aatccgggaa ctgtttcgga ttagcttcca    10680

ggctcttaac gaagttttcc aggtgatcgc ggcgcgacag catattattc aggcgcgctt    10740

caaacagggc gtcggtcaaa tcgctggtat cgaaaacgaa gatatccatc atcagcttca    10800

ggttttcgat agtcggctga cgataaagct gattcagtcg cttaatacct tcggttggca    10860

tcggcgtaaa caaactcatg ccgcccgtac cgccgcccat cagcaccagt ttgccgacgc    10920

gctccggcca gttaagggtg aacgccacag aactatggcc gcccatcgag ttgcccagca    10980

ggtggatttt ggcgatatcc agttgatcca ccacgctttt caggattcgt gcattaagat    11040

ccgatcgtga accactatta acgatcgaat cgcttttgcc ccaacccgga caatccagca    11100

ggatcacccg atagcccgcc tctaccagcg gatcgatatt gcggctgaag ttcgcccagc    11160

cagtagcacc cgggccggaa ccatgcagca ggacaacggt ttcgtcgcct tgtccgcagt    11220

cattaaaatg gatgcgcagc gttttacccg cttcttctac attcagaaaa cggctggtgg    11280

cggcttcggt ttgtggctga taactcatca tcttctcctg catattcagt tctctgttct    11340

ggcgcttaac gagccaaatc cggcaatcca ctccgggatt gggcggtaat aacgcccttc    11400

gctacgccag ttgccaaatg cagaaatagc ggcaaaagcg gcgacccagg ttttgatttc    11460

atgtgtcgac tttccggcaa tggcggaaag ctcttcgtta ctgacggcat ccagttcctg    11520

tatgcgtccc tgctccagca aagtcatgaa ctggttatcc caaatcgggt tgagcggatg    11580

cagagttctc tgatcctcaa caaacttctc agcggcgcta atcacccgtt gctgacgcaa    11640

ttcgcgctca ctggcgggta aatctttccc gctccccaac agacggtcgc gcatatgggc    11700

atcggctttc gccagttcgg gcaccggcgg ctgatgggaa agcccaccgg aacccaggaa    11760

cagcacgcgt ttattgagag tgctggtgaa acgtccaatg gcttcaccca acatgcgggt    11820

acgctggaaa ccgggcagcg gcgtggcgac accgttgatg aacacaggca gaactggcac    11880

cttatccagc ccgccgagca ggaactccag tggctgggcg aacccgtggt ccacctgcat    11940

acagtaagaa acggcaagat cgatcccgct cttcatgacg gcatgcgcac aggcctccgc    12000

cagctccaca ggcacgggca gctctcctgc cgcactgccg aaatcaccaa ttgccgtcgc    12060

cccaacgcct aaacagaacg gtggcatcac gtcatagaaa aagccgttgt agtgatctgg    12120

cgcaaacagc accaccagtt caggggagaa agccgcaata cgctcgcggg cgctggcaat    12180

cacgccattg acctcatcga gtacctcttg cgccgggtcg acatatccca ccagcggcga    12240

gtgggaaaga cagtgaagat aagcgtgcat atcaggctac cttttcgaca gaaacgtcgg    12300

catcagggcg ggtcagcgtc atcaccgacg ccagtttatt cagcgtatta cccagggttt    12360

gcggaatggc ggtggcggca acaaagcgat ccgggcgcat caccaccagc gaagcattat    12420

gttgtgcgaa ccagctacgc aggcgacctt gcgtatcccc cacgcgtagt acgccgtcgt    12480

ggttatcctg tgcggtatga atttgcactt ccggcaccac ctgaatgaag cgggtgccca    12540

acgcgcgcca ctgctggatt tgctcgtcgc tcatccccca cagtggattg catccccagc    12600

caattaccgc gaagttcgcg ccgatcgcgt tatcgagcag cgtcacgtcg ccgttttcca    12660

gcgtgacttt cggctgaata aacatcttgc cgaccggaga gtgcttcgct tcgccctctc    12720

gcaccagcgc accgccgtaa tattgcggca tcggcttgaa gcgcatttcg aggaagtagc    12780

gttttactgg cggcagataa ttcaacagcc aggaaacgcc gtcacgtaac gtaccctgcc    12840

agcgtttcgg cggagccagc acgttgcccg ccgtcacgga caggtcaatc atcgctttgg    12900

cgtgatcgcg tcgttcttgt tgataggtat cgagcagcgc atcacgggct ttcccctgga    12960

taaccaacgc cagtttccag gcgaggttaa aggcgtcgcg cataccgctg ttatagccct    13020

gcccctgcca taccggcatg atgtgcgcgg catcgcccgc cagcagtacg cgatcaatac    13080

ggaaacgttg cgccagtcgc gcgttgtggg tgtagacacg ctggcgaatc aattcaacat    13140

tgtccggatt aggcagcact ttgcttaaca gcttgcgcat attttgcggc tcacgcagct    13200

gttcttcggt ttctcctggc atcaccataa attcaaagcg acgtaccgca tgaggtagcg    13260

cggcagaaac atacgggcgc accggatcgc aacacaaata gatatgcggc gtacttaacg    13320

gatcgttggc gatatctacc acaatccact gatttggcgc agttttacct tcaaacggca    13380

cattcagggt gcgacggaca aaacttgccc caccatcaca ggccaccagc cactgggctt    13440

tgactatttc ccgctgccct tctgccgttt tcaggtgcaa ggtcacttcg tcatcttgct    13500

gactgaaggc ctccagctcg cgggaaaaca agcagcgcac attcggaaaa cgcgacaccc    13560

cttccagcat caccgcatcg acctgcggct gaataaaggc gttacggcgc ggccagccaa    13620

attcatcggt cattggctga atatcagcaa aacagcggcc tttcggggtg agaaaacgca    13680

tcgcgtgcca cggcgtagtg tgcggcagaa catcatcgac caggccgacc gactgcatgg    13740

tgcgcagcgc ctcgtcatca ataccaatcg cacgcgggta gtcgatcaac ttatcgagtt    13800

tctccaccac cagcacgtca atgcccatct ggccgagata gttcgccatc atcagcccaa    13860

ccgggccggc accagcgatc gccacctgaa cgctatggtt aacagcaggc tggatgtcag    13920

ggtgttgtat tgccatttca gtacctcacg actcggacaa aatgtcgttg cgcgcacagt    13980

acagcgcaac ttattttgtt aaaaacatgt aaatgatttt ttattgtgcg ctcagtatag    14040

gaagggtgtt ttcggctaca atcaaaacat gcccgaatgt gcaccaggtg caccacgttg    14100

ttttaactat agaaatgtca attaatatgc agaacaatga gcagacggaa tacaaaaccg    14160

tgcgcggctt aacccgcggt ctaatgttat taaatatgtt aaataaactt gatggcggtg    14220

ccagcgtcgg gctgctggcg gaactcagcg gcctgcatcg caccactgtg cggcgactgc    14280

tggagacgct gcaggaagag ggatatgtcc gccgtagccc ctccgatgat agttttcgac    14340

tgaccatcaa agtgcggcaa ttaagcgaag gatttcgtga cgaacagtgg atttctgcac    14400

tggcggcccc actgctgggc gatctgttgc gcgaagtggt atggccgaca gatgtgtcca    14460

cgctggatgt tgatgcaatg gtggtacgcg aaaccactca ccgtttcagc cgcttatcct    14520

ttcaccgggc aatggtcggg cgacgtttgc cgcttctgaa aaccgcctcg ggcctgacct    14580

ggctggcctt ttgcccggaa caagaccgca aggaattaat cgaaatgtta gcctcccgcc    14640

ccggtgatga ctatcaactg gcacgggaac cgttaaagct ggaagccatt ctggcgcgcg    14700

cgcgcaaaga gggttacgga cagaactacc gcggctggga tcaggaggag aagatcgcct    14760

ctatcgccgt accgctgcgc agtgaacaac gggtgattgg ctgtctgaat ctggtgtata    14820

tggcgagcgc aatgaccatt gaacaggcag cggaaaagca tcttccggcg ctacaacggg    14880

tagcaaaaca gatcgaagaa ggggttgaat cgcaggctat tctggtggcc ggaaggcgaa    14940

gcggcatgca tttacgttga caccatcgaa tggcgcaaaa cctttcgcgg tatggcatga    15000

tagcgcccgg aagagagtca attcagggtg gtgaatgtga aaccagtaac gttatacgat    15060

gtcgcagagt atgccggtgt ctcttatcag accgtttccc gcgtggtgaa ccaggccagc    15120

cacgtttctg cgaaaacgcg ggaaaaagtg gaagcggcga tggcggagct gaattacatt    15180

cccaaccgcg tggcacaaca actggcgggc aaacagtcgt tgctgattgg cgttgccacc    15240

tccagtctgg ccctgcacgc gccgtcgcaa attgtcgcgg cgattaaatc tcgcgccgat    15300

caactgggtg ccagcgtggt ggtgtcgatg gtagaacgaa gcggcgtcga agcctgtaaa    15360

gcggcggtgc acaatcttct cgcgcaacgc gtcagtgggc tgatcattaa ctatccgctg    15420

gatgaccagg atgccattgc tgtggaagct gcctgcacta atgttccggc gttatttctt    15480

gatgtctctg accagacacc catcaacagt attattttct cccatgaaga cggtacgcga    15540

ctgggcgtgg agcatctggt cgcattgggt caccagcaaa tcgcgctgtt agcgggccca    15600

ttaagttctg tctcggcgcg tctgcgtctg gctggctggc ataaatatct cactcgcaat    15660

caaattcagc cgatagcgga acgggaaggc gactggagtg ccatgtccgg ttttcaacaa    15720

accatgcaaa tgctgaatga gggcatcgtt cccactgcga tgctggttgc caacgatcag    15780

atggcgctgg gcgcaatgcg cgccattacc gagtccgggc tgcgcgttgg tgcggatatc    15840

tcggtagtgg gatacgacga taccgaagac agctcatgtt atatcccgcc gttaaccacc    15900

atcaaacagg attttcgcct gctggggcaa accagcgtgg accgcttgct gcaactctct    15960

cagggccagg cggtgaaggg caatcagctg ttgcccgtct cactggtgaa aagaaaaacc    16020

accctggcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag    16080

ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtaac    16140

taggcacccc aggctttaca ctttatgctt ccggctggta taatgtgtgg acctgtagaa    16200

ataattttgt ttaactttaa taaggagata taccatggga ggcagtactg ttgcaccaac    16260

tacaccgttg gcaaccggcg gtgcgctccg caaagtgcga caagccgtct ttcccatcta    16320

cggaaaccaa gaagtcacca aatttctgct catcggatcc attaaattct ttataatctt    16380

ggcactcacg ctcacgcgtg ataccaagga cacgttgatt gtcacgcaat gtggtgccga    16440

agcgattgcc tttctcaaaa tatacggggt gctacccgca gcgaccgcat ttatcgcgct    16500

ctattccaaa atgtccaacg ccatgggcaa aaaaatgcta ttttattcca cttgcattcc    16560

tttctttacc tttttcgggc tgtttgatgt tttcatttac ccgaacgcgg agcgactgca    16620

ccctagtttg gaagccgtgc aggcaattct cccgggcggt gccgcatctg gcggcatggc    16680

ggttctggcc aagattgcga cacactggac atcggcctta ttttacgtca tggcggaaat    16740

atattcttcc gtatcggtgg ggctattgtt ttggcagttt gcgaacgacg tcgtcaacgt    16800

ggatcaggcc aagcgctttt atccattatt tgctcaaatg agtggcctcg ctccagtttt    16860

agcgggccag tatgtggtac ggtttgccag caaagcggtc aactttgagg catccatgca    16920

tcgactcacg gcggccgtaa catttgctgg tattatgatt tgcatctttt accaactcag    16980

ttcgtcatat gtggagcgaa cggaatcagc aaagccagcg gcagataacg agcagtctat    17040

caaaccgaaa aagaagaaac ccaaaatgtc catggttgaa tcggggaaat ttctcgcgtc    17100

aagtcagtac ctgcgtctaa ttgccatgct ggtgctggga tacggcctca gtattaactt    17160

taccgaaatc atgtggaaaa gcttggtgaa gaaacaatat ccagacccgc tagattatca    17220

acgatttatg ggtaacttct cgtcagcggt tggtttgagc acatgcattg ttattttctt    17280

cggtgtgcac gtgatccgtt tgttggggtg gaaagtcgga gcgttggcta cacctgggat    17340

catggccatt ctagcgttac ccttttttgc ttgcattttg ttgggtttgg atagtccagc    17400

acgattggag atcgccgtaa tctttggaac aattcagagt ttgctgagca aaacctccaa    17460

gtatgccctt ttcgacccta ccacacaaat ggcttatatt cctctggacg acgaatcaaa    17520

ggtcaaagga aaagcggcaa ttgatgtttt gggatcgcgg attggcaaga gtggaggctc    17580

actgatccag cagggcttgg tctttgtttt tggaaatatc attaatgccg cacctgtagt    17640

aggggttgtc tactacagtg tccttgttgc gtggatgagc gcagctggcc gactaagtgg    17700

gctttttcaa gcacaaacag aaatggataa ggccgacaaa atggaggcaa agaccaacaa    17760

agaaaagtag ttaacctagg ctgctgccac cgctgagcaa taagactcct gttgatagat    17820

ccagtaatga cctcagaact ccatctggat ttgttcagaa cgctcggttg ccgccgggcg    17880

ttttttattg gtgagaat                                                  17898


<210> 6
<211> 125
<212> DNA
<213> Escherichia coli

<400> 6
aggagtaaaa atgattccgg ggatccgtcg acctgcagtt cgaagttcct attctctaga       60

aagtatagga acttcgaagc agctccagcc tacagaaact aacgaagatt tttaatcgtc      120

ttgtt                                                                  125


<210> 7
<211> 1082
<212> DNA
<213> Escherichia coli

<400> 7
aggagtaaaa atggctatcg acgaaaacaa acagaaagcg ttggcggcag cactgggcca       60

gattgagaaa caatttggta aaggctccat catgcgcctg ggtgaagacc gttccatgga      120

tgtggaaacc atctctaccg gttcgctttc actggatatc gcgcttgggg caggtggtct      180

gccgatgggc cgtatcgtcg aaatctacgg accggaatct tccggtaaaa ccacgctgac      240

gctgcaggtg atcgccgcag cgcagcgtga aggtaaaacc tgtgcgttta tcgatgctga      300

acacgcgctg gacccaatct acgcacgtaa actgggcgtc gatatcgata acctgctgtg      360

ctcccagccg gacaccggcg agcaggcact ggaaatctgt gacgccctgg cgcgttctgg      420

cgcagtagac gttatcgtcg ttgactccgt ggcggcactg acgccgaaag cggaaatcga      480

aggcgaaatc ggcgactctc acatgggcct tgcggcacgt atgatgagcc aggcgatgcg      540

taagctggcg ggtaacctga agcagtccaa cacgctgctg atcttcatca accagatccg      600

tatgaaaatt ggtgtgatgt tcggtaaccc ggaaaccact accggtggta acgcgctgaa      660

attctacgcc tctgttcgtc tcgacatccg tcgtatcggc gcggtgaaag agggcgaaaa      720

cgtggtgggt agcgaaaccc gcgtgaaagt ggtgaagaac aaaatcgctg cgccgtttaa      780

acaggctgaa ttccagatcc tctacggcga aggtatcaac ttctacggcg aactggttga      840

cctgggcgta aaagagaagc tgatcgagaa agcaggcgcg tggtacagct acaaaggtga      900

gaagatcggt cagggtaaag cgaatgcgac tgcctggctg aaagataacc cggaaaccgc      960

gaaagagatc gagaagaaag tacgtgagtt gctgctgagc aacccgaact caacgccgga     1020

tttctctgta gatgatagcg aaggcgtagc agaaactaac gaagattttt aatcgtcttg     1080

tt                                                                    1082


<210> 8
<211> 783
<212> PRT
<213> Escherichia coli

<400> 8
Met Ala Gln Ala Gly Phe Ile Leu Thr Arg His Trp Arg Asp Thr Pro 
1               5                   10                  15      


Gln Gly Thr Glu Val Ser Phe Trp Leu Ala Thr Asp Asn Gly Pro Leu 
            20                  25                  30          


Gln Val Thr Leu Ala Pro Gln Glu Ser Val Ala Phe Ile Pro Ala Asp 
        35                  40                  45              


Gln Val Pro Arg Ala Gln His Ile Leu Gln Gly Glu Gln Gly Val Arg 
    50                  55                  60                  


Leu Thr Pro Leu Ala Leu Lys Asp Phe His Arg Gln Pro Val Tyr Gly 
65                  70                  75                  80  


Leu Tyr Cys Arg Ala His Arg Gln Leu Met Asn Tyr Glu Lys Arg Leu 
                85                  90                  95      


Arg Glu Gly Gly Val Thr Val Tyr Glu Ala Asp Val Arg Pro Pro Glu 
            100                 105                 110         


Arg Tyr Leu Met Glu Arg Phe Ile Thr Ser Pro Val Trp Val Glu Gly 
        115                 120                 125             


Asp Met His Asn Gly Ala Ile Val Asn Ala Arg Leu Lys Pro His Pro 
    130                 135                 140                 


Asp Tyr Arg Pro Pro Leu Lys Trp Val Ser Ile Asp Ile Glu Thr Thr 
145                 150                 155                 160 


Arg His Gly Glu Leu Tyr Cys Ile Gly Leu Glu Gly Cys Gly Gln Arg 
                165                 170                 175     


Ile Val Tyr Met Leu Gly Pro Glu Asn Gly Asp Ala Ser Ala Leu Asp 
            180                 185                 190         


Phe Glu Leu Glu Tyr Val Ala Ser Arg Pro Gln Leu Leu Glu Lys Leu 
        195                 200                 205             


Asn Ala Trp Phe Ala Asn Tyr Asp Pro Asp Val Ile Ile Gly Trp Asn 
    210                 215                 220                 


Val Val Gln Phe Asp Leu Arg Met Leu Gln Lys His Ala Glu Arg Tyr 
225                 230                 235                 240 


Arg Ile Pro Leu Arg Leu Gly Arg Asp Asn Ser Glu Leu Glu Trp Arg 
                245                 250                 255     


Glu His Gly Phe Lys Asn Gly Val Phe Phe Ala Gln Ala Lys Gly Arg 
            260                 265                 270         


Leu Ile Ile Asp Gly Ile Glu Ala Leu Lys Ser Ala Phe Trp Asn Phe 
        275                 280                 285             


Ser Ser Phe Ser Leu Glu Thr Val Ala Gln Glu Leu Leu Gly Glu Gly 
    290                 295                 300                 


Lys Ser Ile Asp Asn Pro Trp Asp Arg Met Asp Glu Ile Asp Arg Arg 
305                 310                 315                 320 


Phe Ala Glu Asp Lys Pro Ala Leu Ala Thr Tyr Asn Leu Lys Asp Cys 
                325                 330                 335     


Glu Leu Val Thr Gln Ile Phe His Lys Thr Glu Ile Met Pro Phe Leu 
            340                 345                 350         


Leu Glu Arg Ala Thr Val Asn Gly Leu Pro Val Asp Arg His Gly Gly 
        355                 360                 365             


Ser Val Ala Ala Phe Gly His Leu Tyr Phe Pro Arg Met His Arg Ala 
    370                 375                 380                 


Gly Tyr Val Ala Pro Asn Leu Gly Glu Val Pro Pro His Ala Ser Pro 
385                 390                 395                 400 


Gly Gly Tyr Val Met Asp Ser Arg Pro Gly Leu Tyr Asp Ser Val Leu 
                405                 410                 415     


Val Leu Asp Tyr Lys Ser Leu Tyr Pro Ser Ile Ile Arg Thr Phe Leu 
            420                 425                 430         


Ile Asp Pro Val Gly Leu Val Glu Gly Met Ala Gln Pro Asp Pro Glu 
        435                 440                 445             


His Ser Thr Glu Gly Phe Leu Asp Ala Trp Phe Ser Arg Glu Lys His 
    450                 455                 460                 


Cys Leu Pro Glu Ile Val Thr Asn Ile Trp His Gly Arg Asp Glu Ala 
465                 470                 475                 480 


Lys Arg Gln Gly Asn Lys Pro Leu Ser Gln Ala Leu Lys Ile Ile Met 
                485                 490                 495     


Asn Ala Phe Tyr Gly Val Leu Gly Thr Thr Ala Cys Arg Phe Phe Asp 
            500                 505                 510         


Pro Arg Leu Ala Ser Ser Ile Thr Met Arg Gly His Gln Ile Met Arg 
        515                 520                 525             


Gln Thr Lys Ala Leu Ile Glu Ala Gln Gly Tyr Asp Val Ile Tyr Gly 
    530                 535                 540                 


Asp Thr Asp Ser Thr Phe Val Trp Leu Lys Gly Ala His Ser Glu Glu 
545                 550                 555                 560 


Glu Ala Ala Lys Ile Gly Arg Ala Leu Val Gln His Val Asn Ala Trp 
                565                 570                 575     


Trp Ala Glu Thr Leu Gln Lys Gln Arg Leu Thr Ser Ala Leu Glu Leu 
            580                 585                 590         


Glu Tyr Glu Thr His Phe Cys Arg Phe Leu Met Pro Thr Ile Arg Gly 
        595                 600                 605             


Ala Asp Thr Gly Ser Lys Lys Arg Tyr Ala Gly Leu Ile Gln Glu Gly 
    610                 615                 620                 


Asp Lys Gln Arg Met Val Phe Lys Gly Leu Glu Thr Val Arg Thr Asp 
625                 630                 635                 640 


Trp Thr Pro Leu Ala Gln Gln Phe Gln Gln Glu Leu Tyr Leu Arg Ile 
                645                 650                 655     


Phe Arg Asn Glu Pro Tyr Gln Glu Tyr Val Arg Glu Thr Ile Asp Lys 
            660                 665                 670         


Leu Met Ala Gly Glu Leu Asp Ala Arg Leu Val Tyr Arg Lys Arg Leu 
        675                 680                 685             


Arg Arg Pro Leu Ser Glu Tyr Gln Arg Asn Val Pro Pro His Val Arg 
    690                 695                 700                 


Ala Ala Arg Leu Ala Asp Glu Glu Asn Gln Lys Arg Gly Arg Pro Leu 
705                 710                 715                 720 


Gln Tyr Gln Asn Arg Gly Thr Ile Lys Tyr Val Trp Thr Thr Asn Gly 
                725                 730                 735     


Pro Glu Pro Leu Asp Tyr Gln Arg Ser Pro Leu Asp Tyr Glu His Tyr 
            740                 745                 750         


Leu Thr Arg Gln Leu Gln Pro Val Ala Glu Gly Ile Leu Pro Phe Ile 
        755                 760                 765             


Glu Asp Asn Phe Ala Thr Leu Met Thr Gly Gln Leu Gly Leu Phe 
    770                 775                 780             


<210> 9
<211> 320
<212> PRT
<213> Escherichia coli

<400> 9
Met Ala Ile Ser Ser Arg Asn Thr Leu Leu Ala Ala Leu Ala Phe Ile 
1               5                   10                  15      


Ala Phe Gln Ala Gln Ala Val Asn Val Thr Val Ala Tyr Gln Thr Ser 
            20                  25                  30          


Ala Glu Pro Ala Lys Val Ala Gln Ala Asp Asn Thr Phe Ala Lys Glu 
        35                  40                  45              


Ser Gly Ala Thr Val Asp Trp Arg Lys Phe Asp Ser Gly Ala Ser Ile 
    50                  55                  60                  


Val Arg Ala Leu Ala Ser Gly Asp Val Gln Ile Gly Asn Leu Gly Ser 
65                  70                  75                  80  


Ser Pro Leu Ala Val Ala Ala Ser Gln Gln Val Pro Ile Glu Val Phe 
                85                  90                  95      


Leu Leu Ala Ser Lys Leu Gly Asn Ser Glu Ala Leu Val Val Lys Lys 
            100                 105                 110         


Thr Ile Ser Lys Pro Glu Asp Leu Ile Gly Lys Arg Ile Ala Val Pro 
        115                 120                 125             


Phe Ile Ser Thr Thr His Tyr Ser Leu Leu Ala Ala Leu Lys His Trp 
    130                 135                 140                 


Gly Ile Lys Pro Gly Gln Val Glu Ile Val Asn Leu Gln Pro Pro Ala 
145                 150                 155                 160 


Ile Ile Ala Ala Trp Gln Arg Gly Asp Ile Asp Gly Ala Tyr Val Trp 
                165                 170                 175     


Ala Pro Ala Val Asn Ala Leu Glu Lys Asp Gly Lys Val Leu Thr Asp 
            180                 185                 190         


Ser Glu Gln Val Gly Gln Trp Gly Ala Pro Thr Leu Asp Val Trp Val 
        195                 200                 205             


Val Arg Lys Asp Phe Ala Glu Lys His Pro Glu Val Val Lys Ala Phe 
    210                 215                 220                 


Ala Lys Ser Ala Ile Asp Ala Gln Gln Pro Tyr Ile Ala Asn Pro Asp 
225                 230                 235                 240 


Ala Trp Leu Lys Gln Pro Glu Asn Ile Ser Lys Leu Ala Arg Leu Ser 
                245                 250                 255     


Gly Val Pro Glu Gly Asp Val Pro Gly Leu Val Lys Gly Asn Thr Tyr 
            260                 265                 270         


Leu Thr Pro Gln Gln Gln Thr Ala Glu Leu Thr Gly Pro Val Asn Lys 
        275                 280                 285             


Ala Ile Ile Asp Thr Ala Gln Phe Leu Lys Glu Gln Gly Lys Val Pro 
    290                 295                 300                 


Ala Val Ala Asn Asp Tyr Ser Gln Tyr Val Thr Ser Arg Phe Val Gln 
305                 310                 315                 320 


<210> 10
<211> 91
<212> PRT
<213> Escherichia coli

<400> 10
Met Ala Ser Val Ser Ile Ser Cys Pro Ser Cys Ser Ala Thr Asp Gly 
1               5                   10                  15      


Val Val Arg Asn Gly Lys Ser Thr Ala Gly His Gln Arg Tyr Leu Cys 
            20                  25                  30          


Ser His Cys Arg Lys Thr Trp Gln Leu Gln Phe Thr Tyr Thr Ala Ser 
        35                  40                  45              


Gln Pro Gly Thr His Gln Lys Ile Ile Asp Met Ala Met Asn Gly Val 
    50                  55                  60                  


Gly Cys Arg Ala Thr Ala Arg Ile Met Gly Val Gly Leu Asn Thr Ile 
65                  70                  75                  80  


Leu Arg His Leu Lys Asn Ser Gly Arg Ser Arg 
                85                  90      


<210> 11
<211> 167
<212> PRT
<213> Escherichia coli

<400> 11
Met Pro Gly Asn Cys Pro His Tyr Gly Arg Trp Pro Gln His Asp Phe 
1               5                   10                  15      


Thr Ser Leu Lys Lys Leu Arg Pro Gln Ser Val Thr Ser Arg Ile Gln 
            20                  25                  30          


Pro Gly Ser Asp Val Ile Val Cys Ala Glu Met Asp Glu Gln Trp Gly 
        35                  40                  45              


Tyr Val Gly Ala Lys Ser Arg Gln Arg Trp Leu Phe Tyr Ala Tyr Asp 
    50                  55                  60                  


Arg Leu Arg Lys Thr Val Val Ala His Val Phe Gly Glu Arg Thr Met 
65                  70                  75                  80  


Ala Thr Leu Gly Arg Leu Met Ser Leu Met Ser Pro Phe Asp Val Val 
                85                  90                  95      


Ile Trp Met Thr Asp Gly Trp Pro Leu Tyr Glu Ser Arg Leu Lys Gly 
            100                 105                 110         


Lys Leu His Val Ile Ser Lys Arg Tyr Thr Gln Arg Ile Glu Arg His 
        115                 120                 125             


Asn Leu Asn Leu Arg Gln His Leu Ala Arg Leu Gly Arg Lys Ser Leu 
    130                 135                 140                 


Ser Phe Ser Lys Ser Val Glu Leu His Asp Lys Val Ile Gly His Tyr 
145                 150                 155                 160 


Leu Asn Ile Lys His Tyr Gln 
                165         


<210> 12
<211> 511
<212> PRT
<213> Escherichia coli

<400> 12
Met Gly Gly Ser Thr Val Ala Pro Thr Thr Pro Leu Ala Thr Gly Gly 
1               5                   10                  15      


Ala Leu Arg Lys Val Arg Gln Ala Val Phe Pro Ile Tyr Gly Asn Gln 
            20                  25                  30          


Glu Val Thr Lys Phe Leu Leu Ile Gly Ser Ile Lys Phe Phe Ile Ile 
        35                  40                  45              


Leu Ala Leu Thr Leu Thr Arg Asp Thr Lys Asp Thr Leu Ile Val Thr 
    50                  55                  60                  


Gln Cys Gly Ala Glu Ala Ile Ala Phe Leu Lys Ile Tyr Gly Val Leu 
65                  70                  75                  80  


Pro Ala Ala Thr Ala Phe Ile Ala Leu Tyr Ser Lys Met Ser Asn Ala 
                85                  90                  95      


Met Gly Lys Lys Met Leu Phe Tyr Ser Thr Cys Ile Pro Phe Phe Thr 
            100                 105                 110         


Phe Phe Gly Leu Phe Asp Val Phe Ile Tyr Pro Asn Ala Glu Arg Leu 
        115                 120                 125             


His Pro Ser Leu Glu Ala Val Gln Ala Ile Leu Pro Gly Gly Ala Ala 
    130                 135                 140                 


Ser Gly Gly Met Ala Val Leu Ala Lys Ile Ala Thr His Trp Thr Ser 
145                 150                 155                 160 


Ala Leu Phe Tyr Val Met Ala Glu Ile Tyr Ser Ser Val Ser Val Gly 
                165                 170                 175     


Leu Leu Phe Trp Gln Phe Ala Asn Asp Val Val Asn Val Asp Gln Ala 
            180                 185                 190         


Lys Arg Phe Tyr Pro Leu Phe Ala Gln Met Ser Gly Leu Ala Pro Val 
        195                 200                 205             


Leu Ala Gly Gln Tyr Val Val Arg Phe Ala Ser Lys Ala Val Asn Phe 
    210                 215                 220                 


Glu Ala Ser Met His Arg Leu Thr Ala Ala Val Thr Phe Ala Gly Ile 
225                 230                 235                 240 


Met Ile Cys Ile Phe Tyr Gln Leu Ser Ser Ser Tyr Val Glu Arg Thr 
                245                 250                 255     


Glu Ser Ala Lys Pro Ala Ala Asp Asn Glu Gln Ser Ile Lys Pro Lys 
            260                 265                 270         


Lys Lys Lys Pro Lys Met Ser Met Val Glu Ser Gly Lys Phe Leu Ala 
        275                 280                 285             


Ser Ser Gln Tyr Leu Arg Leu Ile Ala Met Leu Val Leu Gly Tyr Gly 
    290                 295                 300                 


Leu Ser Ile Asn Phe Thr Glu Ile Met Trp Lys Ser Leu Val Lys Lys 
305                 310                 315                 320 


Gln Tyr Pro Asp Pro Leu Asp Tyr Gln Arg Phe Met Gly Asn Phe Ser 
                325                 330                 335     


Ser Ala Val Gly Leu Ser Thr Cys Ile Val Ile Phe Phe Gly Val His 
            340                 345                 350         


Val Ile Arg Leu Leu Gly Trp Lys Val Gly Ala Leu Ala Thr Pro Gly 
        355                 360                 365             


Ile Met Ala Ile Leu Ala Leu Pro Phe Phe Ala Cys Ile Leu Leu Gly 
    370                 375                 380                 


Leu Asp Ser Pro Ala Arg Leu Glu Ile Ala Val Ile Phe Gly Thr Ile 
385                 390                 395                 400 


Gln Ser Leu Leu Ser Lys Thr Ser Lys Tyr Ala Leu Phe Asp Pro Thr 
                405                 410                 415     


Thr Gln Met Ala Tyr Ile Pro Leu Asp Asp Glu Ser Lys Val Lys Gly 
            420                 425                 430         


Lys Ala Ala Ile Asp Val Leu Gly Ser Arg Ile Gly Lys Ser Gly Gly 
        435                 440                 445             


Ser Leu Ile Gln Gln Gly Leu Val Phe Val Phe Gly Asn Ile Ile Asn 
    450                 455                 460                 


Ala Ala Pro Val Val Gly Val Val Tyr Tyr Ser Val Leu Val Ala Trp 
465                 470                 475                 480 


Met Ser Ala Ala Gly Arg Leu Ser Gly Leu Phe Gln Ala Gln Thr Glu 
                485                 490                 495     


Met Asp Lys Ala Asp Lys Met Glu Ala Lys Thr Asn Lys Glu Lys 
            500                 505                 510     


<210> 13
<211> 257
<212> PRT
<213> Escherichia coli

<400> 13
Met Ile Lys Arg Thr Leu Leu Ala Ala Ala Ile Phe Ser Ala Leu Pro 
1               5                   10                  15      


Ala Tyr Ala Gly Leu Thr Ser Ile Thr Ala Gly Tyr Asp Phe Thr Asp 
            20                  25                  30          


Tyr Ser Gly Asp His Gly Asn Arg Asn Leu Ala Tyr Ala Glu Leu Val 
        35                  40                  45              


Ala Lys Val Glu Asn Ala Thr Leu Leu Phe Asn Leu Ser Gln Gly Arg 
    50                  55                  60                  


Arg Asp Tyr Glu Thr Glu His Phe Asn Ala Thr Arg Gly Gln Gly Ala 
65                  70                  75                  80  


Val Trp Tyr Lys Trp Asn Asn Trp Leu Thr Thr Arg Thr Gly Ile Ala 
                85                  90                  95      


Phe Ala Asp Asn Thr Pro Val Phe Ala Arg Gln Asp Phe Arg Gln Asp 
            100                 105                 110         


Ile Asn Leu Ala Leu Leu Pro Lys Thr Leu Phe Thr Thr Gly Tyr Arg 
        115                 120                 125             


Tyr Thr Lys Tyr Tyr Asp Asp Val Glu Val Asp Ala Trp Gln Gly Gly 
    130                 135                 140                 


Val Ser Leu Tyr Thr Gly Pro Val Ile Thr Ser Tyr Arg Tyr Thr His 
145                 150                 155                 160 


Tyr Asp Ser Ser Asp Ala Gly Gly Ser Tyr Ser Asn Met Ile Ser Val 
                165                 170                 175     


Arg Leu Asn Asp Pro Arg Gly Thr Gly Tyr Thr Gln Leu Trp Leu Ser 
            180                 185                 190         


Arg Gly Thr Gly Ala Tyr Thr Tyr Asp Trp Thr Pro Glu Thr Arg Tyr 
        195                 200                 205             


Gly Ser Met Lys Ser Val Ser Leu Gln Arg Ile Gln Pro Leu Thr Glu 
    210                 215                 220                 


Gln Leu Asn Leu Gly Leu Thr Ala Gly Lys Val Trp Tyr Asp Thr Pro 
225                 230                 235                 240 


Thr Asp Asp Tyr Asn Gly Leu Gln Leu Ala Ala His Leu Thr Trp Lys 
                245                 250                 255     


Phe 
    


<210> 14
<211> 91
<212> PRT
<213> Escherichia coli

<400> 14
Met Pro Ser Thr Pro Glu Glu Lys Lys Lys Val Leu Thr Arg Val Arg 
1               5                   10                  15      


Arg Ile Arg Gly Gln Ile Asp Ala Leu Glu Arg Ser Leu Glu Gly Asp 
            20                  25                  30          


Ala Glu Cys Arg Ala Ile Leu Gln Gln Ile Ala Ala Val Arg Gly Ala 
        35                  40                  45              


Ala Asn Gly Leu Met Ala Glu Val Leu Glu Ser His Ile Arg Glu Thr 
    50                  55                  60                  


Phe Asp Arg Asn Asp Cys Tyr Ser Arg Glu Val Ser Gln Ser Val Asp 
65                  70                  75                  80  


Asp Thr Ile Glu Leu Val Arg Ala Tyr Leu Lys 
                85                  90      


<210> 15
<211> 369
<212> PRT
<213> Escherichia coli

<400> 15
Met Lys Ser Arg Ala Ala Val Ala Phe Ala Pro Gly Lys Pro Leu Glu 
1               5                   10                  15      


Ile Val Glu Ile Asp Val Ala Pro Pro Lys Lys Gly Glu Val Leu Ile 
            20                  25                  30          


Lys Val Thr His Thr Gly Val Cys His Thr Asp Ala Phe Thr Leu Ser 
        35                  40                  45              


Gly Asp Asp Pro Glu Gly Val Phe Pro Val Val Leu Gly His Glu Gly 
    50                  55                  60                  


Ala Gly Val Val Val Glu Val Gly Glu Gly Val Thr Ser Val Lys Pro 
65                  70                  75                  80  


Gly Asp His Val Ile Pro Leu Tyr Thr Ala Glu Cys Gly Glu Cys Glu 
                85                  90                  95      


Phe Cys Arg Ser Gly Lys Thr Asn Leu Cys Val Ala Val Arg Glu Thr 
            100                 105                 110         


Gln Gly Lys Gly Leu Met Pro Asp Gly Thr Thr Arg Phe Ser Tyr Asn 
        115                 120                 125             


Gly Gln Pro Leu Tyr His Tyr Met Gly Cys Ser Thr Phe Ser Glu Tyr 
    130                 135                 140                 


Thr Val Val Ala Glu Val Ser Leu Ala Lys Ile Asn Pro Glu Ala Asn 
145                 150                 155                 160 


His Glu His Val Cys Leu Leu Gly Cys Gly Val Thr Thr Gly Ile Gly 
                165                 170                 175     


Ala Val His Asn Thr Ala Lys Val Gln Pro Gly Asp Ser Val Ala Val 
            180                 185                 190         


Phe Gly Leu Gly Ala Ile Gly Leu Ala Val Val Gln Gly Ala Arg Gln 
        195                 200                 205             


Ala Lys Ala Gly Arg Ile Ile Ala Ile Asp Thr Asn Pro Lys Lys Phe 
    210                 215                 220                 


Asp Leu Ala Arg Arg Phe Gly Ala Thr Asp Cys Ile Asn Pro Asn Asp 
225                 230                 235                 240 


Tyr Asp Lys Pro Ile Lys Asp Val Leu Leu Asp Ile Asn Lys Trp Gly 
                245                 250                 255     


Ile Asp His Thr Phe Glu Cys Ile Gly Asn Val Asn Val Met Arg Ala 
            260                 265                 270         


Ala Leu Glu Ser Ala His Arg Gly Trp Gly Gln Ser Val Ile Ile Gly 
        275                 280                 285             


Val Ala Gly Ala Gly Gln Glu Ile Ser Thr Arg Pro Phe Gln Leu Val 
    290                 295                 300                 


Thr Gly Arg Val Trp Lys Gly Ser Ala Phe Gly Gly Val Lys Gly Arg 
305                 310                 315                 320 


Ser Gln Leu Pro Gly Met Val Glu Asp Ala Met Lys Gly Asp Ile Asp 
                325                 330                 335     


Leu Glu Pro Phe Val Thr His Thr Met Ser Leu Asp Glu Ile Asn Asp 
            340                 345                 350         


Ala Phe Asp Leu Met His Glu Gly Lys Ser Ile Arg Thr Val Ile Arg 
        355                 360                 365             


Tyr 
    


<210> 16
<211> 277
<212> PRT
<213> Escherichia coli

<400> 16
Met Glu Leu Ile Glu Lys His Ala Ser Phe Gly Gly Trp Gln Asn Val 
1               5                   10                  15      


Tyr Arg His Tyr Ser Gln Ser Leu Lys Cys Glu Met Asn Val Gly Val 
            20                  25                  30          


Tyr Leu Pro Pro Lys Ala Ala Asn Glu Lys Leu Pro Val Leu Tyr Trp 
        35                  40                  45              


Leu Ser Gly Leu Thr Cys Asn Glu Gln Asn Phe Ile Thr Lys Ser Gly 
    50                  55                  60                  


Met Gln Arg Tyr Ala Ala Glu His Asn Ile Ile Val Val Ala Pro Asp 
65                  70                  75                  80  


Thr Ser Pro Arg Gly Ser His Val Ala Asp Ala Asp Arg Tyr Asp Leu 
                85                  90                  95      


Gly Gln Gly Ala Gly Phe Tyr Leu Asn Ala Thr Gln Ala Pro Trp Asn 
            100                 105                 110         


Glu His Tyr Lys Met Tyr Asp Tyr Ile Arg Asn Glu Leu Pro Asp Leu 
        115                 120                 125             


Val Met His His Phe Pro Ala Thr Ala Lys Lys Ser Ile Ser Gly His 
    130                 135                 140                 


Ser Met Gly Gly Leu Gly Ala Leu Val Leu Ala Leu Arg Asn Pro Asp 
145                 150                 155                 160 


Glu Tyr Val Ser Val Ser Ala Phe Ser Pro Ile Val Ser Pro Ser Gln 
                165                 170                 175     


Val Pro Trp Gly Gln Gln Ala Phe Ala Ala Tyr Leu Ala Glu Asn Lys 
            180                 185                 190         


Asp Ala Trp Leu Asp Tyr Asp Pro Val Ser Leu Ile Ser Gln Gly Gln 
        195                 200                 205             


Arg Val Ala Glu Ile Met Val Asp Gln Gly Leu Ser Asp Asp Phe Tyr 
    210                 215                 220                 


Ala Glu Gln Leu Arg Thr Pro Asn Leu Glu Lys Ile Cys Gln Glu Met 
225                 230                 235                 240 


Asn Ile Lys Thr Leu Ile Arg Tyr His Glu Gly Tyr Asp His Ser Tyr 
                245                 250                 255     


Tyr Phe Val Ser Ser Phe Ile Gly Glu His Ile Ala Tyr His Ala Asn 
            260                 265                 270         


Lys Leu Asn Met Arg 
        275         


<210> 17
<211> 179
<212> PRT
<213> Escherichia coli

<400> 17
Met Ala Lys Leu Thr Leu Gln Glu Gln Leu Leu Lys Ala Gly Leu Val 
1               5                   10                  15      


Thr Ser Lys Lys Ala Ala Lys Val Glu Arg Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Val Gln Ala Arg Glu Ala Arg Ala Ala Val Glu Glu Asn Lys Lys Ala 
        35                  40                  45              


Gln Leu Glu Arg Asp Lys Gln Leu Ser Glu Gln Gln Lys Gln Ala Ala 
    50                  55                  60                  


Leu Ala Lys Glu Tyr Lys Ala Gln Val Lys Gln Leu Ile Glu Met Asn 
65                  70                  75                  80  


Arg Ile Thr Ile Ala Asn Gly Asp Ile Gly Phe Asn Phe Thr Asp Gly 
                85                  90                  95      


Asn Leu Ile Lys Lys Ile Phe Val Asp Lys Leu Thr Gln Ala Gln Leu 
            100                 105                 110         


Ile Asn Gly Arg Leu Ala Ile Ala Arg Leu Leu Val Asp Asn Asn Ser 
        115                 120                 125             


Glu Gly Glu Tyr Ala Ile Ile Pro Ala Ser Val Ala Asp Lys Ile Ala 
    130                 135                 140                 


Gln Arg Asp Ala Ser Ser Ile Val Leu His Ser Ala Leu Ser Ala Glu 
145                 150                 155                 160 


Glu Gln Asp Glu Asp Asp Pro Tyr Ala Asp Phe Lys Val Pro Asp Asp 
                165                 170                 175     


Leu Met Trp 
            


<210> 18
<211> 403
<212> PRT
<213> Escherichia coli

<400> 18
Met Ser Thr Arg Thr Pro Ser Ser Ser Ser Ser Arg Leu Met Leu Thr 
1               5                   10                  15      


Ile Gly Leu Cys Phe Leu Val Ala Leu Met Glu Gly Leu Asp Leu Gln 
            20                  25                  30          


Ala Ala Gly Ile Ala Ala Gly Gly Ile Ala Gln Ala Phe Ala Leu Asp 
        35                  40                  45              


Lys Met Gln Met Gly Trp Ile Phe Ser Ala Gly Ile Leu Gly Leu Leu 
    50                  55                  60                  


Pro Gly Ala Leu Val Gly Gly Met Leu Ala Asp Arg Tyr Gly Arg Lys 
65                  70                  75                  80  


Arg Ile Leu Ile Gly Ser Val Ala Leu Phe Gly Leu Phe Ser Leu Ala 
                85                  90                  95      


Thr Ala Ile Ala Trp Asp Phe Pro Ser Leu Val Phe Ala Arg Leu Met 
            100                 105                 110         


Thr Gly Val Gly Leu Gly Ala Ala Leu Pro Asn Leu Ile Ala Leu Thr 
        115                 120                 125             


Ser Glu Ala Ala Gly Pro Arg Phe Arg Gly Thr Ala Val Ser Leu Met 
    130                 135                 140                 


Tyr Cys Gly Val Pro Ile Gly Ala Ala Leu Ala Ala Thr Leu Gly Phe 
145                 150                 155                 160 


Ala Gly Ala Asn Leu Ala Trp Gln Thr Val Phe Trp Val Gly Gly Val 
                165                 170                 175     


Val Pro Leu Ile Leu Val Pro Leu Leu Met Arg Trp Leu Pro Glu Ser 
            180                 185                 190         


Ala Val Phe Ala Gly Glu Lys Gln Ser Ala Pro Pro Leu Arg Ala Leu 
        195                 200                 205             


Phe Ala Pro Glu Thr Ala Thr Ala Thr Leu Leu Leu Trp Leu Cys Tyr 
    210                 215                 220                 


Phe Phe Thr Leu Leu Val Val Tyr Met Leu Ile Asn Trp Leu Pro Leu 
225                 230                 235                 240 


Leu Leu Val Glu Gln Gly Phe Gln Pro Ser Gln Ala Ala Gly Val Met 
                245                 250                 255     


Phe Ala Leu Gln Met Gly Ala Ala Ser Gly Thr Leu Met Leu Gly Ala 
            260                 265                 270         


Leu Met Asp Lys Leu Arg Pro Val Thr Met Ser Leu Leu Ile Tyr Ser 
        275                 280                 285             


Gly Met Leu Ala Ser Leu Leu Ala Leu Gly Thr Val Ser Ser Phe Asn 
    290                 295                 300                 


Gly Met Leu Leu Ala Gly Phe Val Ala Gly Leu Phe Ala Thr Gly Gly 
305                 310                 315                 320 


Gln Ser Val Leu Tyr Ala Leu Ala Pro Leu Phe Tyr Ser Ser Gln Ile 
                325                 330                 335     


Arg Ala Thr Gly Val Gly Thr Ala Val Ala Val Gly Arg Leu Gly Ala 
            340                 345                 350         


Met Ser Gly Pro Leu Leu Ala Gly Lys Met Leu Ala Leu Gly Thr Gly 
        355                 360                 365             


Thr Val Gly Val Met Ala Ala Ser Ala Pro Gly Ile Leu Val Ala Gly 
    370                 375                 380                 


Leu Ala Val Phe Ile Leu Met Ser Arg Arg Ser Arg Ile Gln Pro Cys 
385                 390                 395                 400 


Ala Asp Ala 
            


<210> 19
<211> 337
<212> PRT
<213> Escherichia coli

<400> 19
Met Asn Gly Lys Lys Leu Tyr Ile Ser Asp Val Thr Leu Arg Asp Gly 
1               5                   10                  15      


Met His Ala Ile Arg His Gln Tyr Ser Leu Glu Asn Val Arg Gln Ile 
            20                  25                  30          


Ala Lys Ala Leu Asp Asp Ala His Val Asp Ser Ile Glu Val Ala His 
        35                  40                  45              


Gly Asp Gly Leu Gln Gly Ser Ser Phe Asn Tyr Gly Phe Gly Ala His 
    50                  55                  60                  


Ser Asp Leu Glu Trp Ile Glu Ala Ala Ala Asp Val Val Lys His Ala 
65                  70                  75                  80  


Lys Ile Ala Thr Leu Leu Leu Pro Gly Ile Gly Thr Ile His Asp Leu 
                85                  90                  95      


Lys Asn Ala Trp Gln Ala Gly Ala Arg Val Val Arg Val Ala Thr His 
            100                 105                 110         


Cys Thr Glu Ala Asp Val Ser Ala Gln His Ile Gln Tyr Ala Arg Glu 
        115                 120                 125             


Leu Gly Met Asp Thr Val Gly Phe Leu Met Met Ser His Met Thr Thr 
    130                 135                 140                 


Pro Glu Asn Leu Ala Lys Gln Ala Lys Leu Met Glu Gly Tyr Gly Ala 
145                 150                 155                 160 


Thr Cys Ile Tyr Val Val Asp Ser Gly Gly Ala Met Asn Met Ser Asp 
                165                 170                 175     


Ile Arg Asp Arg Phe Arg Ala Leu Lys Ala Val Leu Lys Pro Glu Thr 
            180                 185                 190         


Gln Thr Gly Met His Ala His His Asn Leu Ser Leu Gly Val Ala Asn 
        195                 200                 205             


Ser Ile Glu Ala Val Glu Glu Gly Cys Asp Arg Ile Asp Ala Ser Leu 
    210                 215                 220                 


Ala Gly Met Gly Ala Gly Ala Gly Asn Ala Pro Leu Glu Val Phe Ile 
225                 230                 235                 240 


Ala Ala Ala Asp Lys Leu Gly Trp Gln His Gly Thr Asp Leu Tyr Ala 
                245                 250                 255     


Leu Met Asp Ala Ala Asp Asp Leu Val Arg Pro Leu Gln Asp Arg Pro 
            260                 265                 270         


Val Arg Val Asp Arg Glu Thr Leu Ala Leu Gly Tyr Ala Gly Val Tyr 
        275                 280                 285             


Ser Ser Phe Leu Arg His Cys Glu Thr Ala Ala Ala Arg Tyr Gly Leu 
    290                 295                 300                 


Ser Ala Val Asp Ile Leu Val Glu Leu Gly Lys Arg Arg Met Val Gly 
305                 310                 315                 320 


Gly Gln Glu Asp Met Ile Val Asp Val Ala Leu Asp Leu Arg Asn Asn 
                325                 330                 335     


Lys 
    


<210> 20
<211> 316
<212> PRT
<213> Escherichia coli

<400> 20
Met Ser Lys Arg Lys Val Ala Ile Ile Gly Ser Gly Asn Ile Gly Thr 
1               5                   10                  15      


Asp Leu Met Ile Lys Ile Leu Arg His Gly Gln His Leu Glu Met Ala 
            20                  25                  30          


Val Met Val Gly Ile Asp Pro Gln Ser Asp Gly Leu Ala Arg Ala Arg 
        35                  40                  45              


Arg Met Gly Val Ala Thr Thr His Glu Gly Val Ile Gly Leu Met Asn 
    50                  55                  60                  


Met Pro Glu Phe Ala Asp Ile Asp Ile Val Phe Asp Ala Thr Ser Ala 
65                  70                  75                  80  


Gly Ala His Val Lys Asn Asp Ala Ala Leu Arg Glu Ala Lys Pro Asp 
                85                  90                  95      


Ile Arg Leu Ile Asp Leu Thr Pro Ala Ala Ile Gly Pro Tyr Cys Val 
            100                 105                 110         


Pro Val Val Asn Leu Glu Ala Asn Val Asp Gln Leu Asn Val Asn Met 
        115                 120                 125             


Val Thr Cys Gly Gly Gln Ala Thr Ile Pro Met Val Ala Ala Val Ser 
    130                 135                 140                 


Arg Val Ala Arg Val His Tyr Ala Glu Ile Ile Ala Ser Ile Ala Ser 
145                 150                 155                 160 


Lys Ser Ala Gly Pro Gly Thr Arg Ala Asn Ile Asp Glu Phe Thr Glu 
                165                 170                 175     


Thr Thr Ser Arg Ala Ile Glu Val Val Gly Gly Ala Ala Lys Gly Lys 
            180                 185                 190         


Ala Ile Ile Val Leu Asn Pro Ala Glu Pro Pro Leu Met Met Arg Asp 
        195                 200                 205             


Thr Val Tyr Val Leu Ser Asp Glu Ala Ser Gln Asp Asp Ile Glu Ala 
    210                 215                 220                 


Ser Ile Asn Glu Met Ala Glu Ala Val Gln Ala Tyr Val Pro Gly Tyr 
225                 230                 235                 240 


Arg Leu Lys Gln Arg Val Gln Phe Glu Val Ile Pro Gln Asp Lys Pro 
                245                 250                 255     


Val Asn Leu Pro Gly Val Gly Gln Phe Ser Gly Leu Lys Thr Ala Val 
            260                 265                 270         


Trp Leu Glu Val Glu Gly Ala Ala His Tyr Leu Pro Ala Tyr Ala Gly 
        275                 280                 285             


Asn Leu Asp Ile Met Thr Ser Ser Ala Leu Ala Thr Ala Glu Lys Met 
    290                 295                 300                 


Ala Gln Ser Leu Ala Arg Lys Ala Gly Glu Ala Ala 
305                 310                 315     


<210> 21
<211> 269
<212> PRT
<213> Escherichia coli

<400> 21
Met Thr Lys His Thr Leu Glu Gln Leu Ala Ala Asp Leu Arg Arg Ala 
1               5                   10                  15      


Ala Glu Gln Gly Glu Ala Ile Ala Pro Leu Arg Asp Leu Ile Gly Ile 
            20                  25                  30          


Asp Asn Ala Glu Ala Ala Tyr Ala Ile Gln His Ile Asn Val Gln Tyr 
        35                  40                  45              


Asp Val Ala Gln Gly Arg Arg Val Val Gly Arg Lys Val Gly Leu Thr 
    50                  55                  60                  


His Pro Lys Val Gln Gln Gln Leu Gly Val Asp Gln Pro Asp Phe Gly 
65                  70                  75                  80  


Thr Leu Phe Ala Asp Met Cys Tyr Gly Asp Asn Glu Ile Ile Pro Phe 
                85                  90                  95      


Ser Arg Val Leu Gln Pro Arg Ile Glu Ala Glu Ile Ala Leu Val Leu 
            100                 105                 110         


Asn Arg Asp Leu Pro Ala Thr Asp Ile Thr Phe Asp Glu Leu Tyr Asn 
        115                 120                 125             


Ala Ile Glu Trp Val Leu Pro Ala Leu Glu Val Val Gly Ser Arg Ile 
    130                 135                 140                 


Arg Asp Trp Ser Ile Gln Phe Val Asp Thr Val Ala Asp Asn Ala Ser 
145                 150                 155                 160 


Cys Gly Val Tyr Val Ile Gly Gly Pro Ala Gln Arg Pro Ala Gly Leu 
                165                 170                 175     


Asp Leu Lys Asn Cys Ala Met Lys Met Thr Arg Asn Asn Glu Glu Val 
            180                 185                 190         


Ser Ser Gly Arg Gly Ser Glu Cys Leu Gly His Pro Leu Asn Ala Ala 
        195                 200                 205             


Val Trp Leu Ala Arg Lys Met Ala Ser Leu Gly Glu Pro Leu Arg Thr 
    210                 215                 220                 


Gly Asp Ile Ile Leu Thr Gly Ala Leu Gly Pro Met Val Ala Val Asn 
225                 230                 235                 240 


Ala Gly Asp Arg Phe Glu Ala His Ile Glu Gly Ile Gly Ser Val Ala 
                245                 250                 255     


Ala Thr Phe Ser Ser Ala Ala Pro Lys Gly Ser Leu Ser 
            260                 265                 


<210> 22
<211> 293
<212> PRT
<213> Escherichia coli

<400> 22
Met Gln Glu Lys Met Met Ser Tyr Gln Pro Gln Thr Glu Ala Ala Thr 
1               5                   10                  15      


Ser Arg Phe Leu Asn Val Glu Glu Ala Gly Lys Thr Leu Arg Ile His 
            20                  25                  30          


Phe Asn Asp Cys Gly Gln Gly Asp Glu Thr Val Val Leu Leu His Gly 
        35                  40                  45              


Ser Gly Pro Gly Ala Thr Gly Trp Ala Asn Phe Ser Arg Asn Ile Asp 
    50                  55                  60                  


Pro Leu Val Glu Ala Gly Tyr Arg Val Ile Leu Leu Asp Cys Pro Gly 
65                  70                  75                  80  


Trp Gly Lys Ser Asp Ser Ile Val Asn Ser Gly Ser Arg Ser Asp Leu 
                85                  90                  95      


Asn Ala Arg Ile Leu Lys Ser Val Val Asp Gln Leu Asp Ile Ala Lys 
            100                 105                 110         


Ile His Leu Leu Gly Asn Ser Met Gly Gly His Ser Ser Val Ala Phe 
        115                 120                 125             


Thr Leu Asn Trp Pro Glu Arg Val Gly Lys Leu Val Leu Met Gly Gly 
    130                 135                 140                 


Gly Thr Gly Gly Met Ser Leu Phe Thr Pro Met Pro Thr Glu Gly Ile 
145                 150                 155                 160 


Lys Arg Leu Asn Gln Leu Tyr Arg Gln Pro Thr Ile Glu Asn Leu Lys 
                165                 170                 175     


Leu Met Met Asp Ile Phe Val Phe Asp Thr Ser Asp Leu Thr Asp Ala 
            180                 185                 190         


Leu Phe Glu Ala Arg Leu Asn Asn Met Leu Ser Arg Arg Asp His Leu 
        195                 200                 205             


Glu Asn Phe Val Lys Ser Leu Glu Ala Asn Pro Lys Gln Phe Pro Asp 
    210                 215                 220                 


Phe Gly Pro Arg Leu Ala Glu Ile Lys Ala Gln Thr Leu Ile Val Trp 
225                 230                 235                 240 


Gly Arg Asn Asp Arg Phe Val Pro Met Asp Ala Gly Leu Arg Leu Leu 
                245                 250                 255     


Ser Gly Ile Ala Gly Ser Glu Leu His Ile Phe Arg Asp Cys Gly His 
            260                 265                 270         


Trp Ala Gln Trp Glu His Ala Asp Ala Phe Asn Gln Leu Val Leu Asn 
        275                 280                 285             


Phe Leu Ala Arg Pro 
    290             


<210> 23
<211> 314
<212> PRT
<213> Escherichia coli

<400> 23
Met His Ala Tyr Leu His Cys Leu Ser His Ser Pro Leu Val Gly Tyr 
1               5                   10                  15      


Val Asp Pro Ala Gln Glu Val Leu Asp Glu Val Asn Gly Val Ile Ala 
            20                  25                  30          


Ser Ala Arg Glu Arg Ile Ala Ala Phe Ser Pro Glu Leu Val Val Leu 
        35                  40                  45              


Phe Ala Pro Asp His Tyr Asn Gly Phe Phe Tyr Asp Val Met Pro Pro 
    50                  55                  60                  


Phe Cys Leu Gly Val Gly Ala Thr Ala Ile Gly Asp Phe Gly Ser Ala 
65                  70                  75                  80  


Ala Gly Glu Leu Pro Val Pro Val Glu Leu Ala Glu Ala Cys Ala His 
                85                  90                  95      


Ala Val Met Lys Ser Gly Ile Asp Leu Ala Val Ser Tyr Cys Met Gln 
            100                 105                 110         


Val Asp His Gly Phe Ala Gln Pro Leu Glu Phe Leu Leu Gly Gly Leu 
        115                 120                 125             


Asp Lys Val Pro Val Leu Pro Val Phe Ile Asn Gly Val Ala Thr Pro 
    130                 135                 140                 


Leu Pro Gly Phe Gln Arg Thr Arg Met Leu Gly Glu Ala Ile Gly Arg 
145                 150                 155                 160 


Phe Thr Ser Thr Leu Asn Lys Arg Val Leu Phe Leu Gly Ser Gly Gly 
                165                 170                 175     


Leu Ser His Gln Pro Pro Val Pro Glu Leu Ala Lys Ala Asp Ala His 
            180                 185                 190         


Met Arg Asp Arg Leu Leu Gly Ser Gly Lys Asp Leu Pro Ala Ser Glu 
        195                 200                 205             


Arg Glu Leu Arg Gln Gln Arg Val Ile Ser Ala Ala Glu Lys Phe Val 
    210                 215                 220                 


Glu Asp Gln Arg Thr Leu His Pro Leu Asn Pro Ile Trp Asp Asn Gln 
225                 230                 235                 240 


Phe Met Thr Leu Leu Glu Gln Gly Arg Ile Gln Glu Leu Asp Ala Val 
                245                 250                 255     


Ser Asn Glu Glu Leu Ser Ala Ile Ala Gly Lys Ser Thr His Glu Ile 
            260                 265                 270         


Lys Thr Trp Val Ala Ala Phe Ala Ala Ile Ser Ala Phe Gly Asn Trp 
        275                 280                 285             


Arg Ser Glu Gly Arg Tyr Tyr Arg Pro Ile Pro Glu Trp Ile Ala Gly 
    290                 295                 300                 


Phe Gly Ser Leu Ser Ala Arg Thr Glu Asn 
305                 310                 


<210> 24
<211> 554
<212> PRT
<213> Escherichia coli

<400> 24
Met Ala Ile Gln His Pro Asp Ile Gln Pro Ala Val Asn His Ser Val 
1               5                   10                  15      


Gln Val Ala Ile Ala Gly Ala Gly Pro Val Gly Leu Met Met Ala Asn 
            20                  25                  30          


Tyr Leu Gly Gln Met Gly Ile Asp Val Leu Val Val Glu Lys Leu Asp 
        35                  40                  45              


Lys Leu Ile Asp Tyr Pro Arg Ala Ile Gly Ile Asp Asp Glu Ala Leu 
    50                  55                  60                  


Arg Thr Met Gln Ser Val Gly Leu Val Asp Asp Val Leu Pro His Thr 
65                  70                  75                  80  


Thr Pro Trp His Ala Met Arg Phe Leu Thr Pro Lys Gly Arg Cys Phe 
                85                  90                  95      


Ala Asp Ile Gln Pro Met Thr Asp Glu Phe Gly Trp Pro Arg Arg Asn 
            100                 105                 110         


Ala Phe Ile Gln Pro Gln Val Asp Ala Val Met Leu Glu Gly Val Ser 
        115                 120                 125             


Arg Phe Pro Asn Val Arg Cys Leu Phe Ser Arg Glu Leu Glu Ala Phe 
    130                 135                 140                 


Ser Gln Gln Asp Asp Glu Val Thr Leu His Leu Lys Thr Ala Glu Gly 
145                 150                 155                 160 


Gln Arg Glu Ile Val Lys Ala Gln Trp Leu Val Ala Cys Asp Gly Gly 
                165                 170                 175     


Ala Ser Phe Val Arg Arg Thr Leu Asn Val Pro Phe Glu Gly Lys Thr 
            180                 185                 190         


Ala Pro Asn Gln Trp Ile Val Val Asp Ile Ala Asn Asp Pro Leu Ser 
        195                 200                 205             


Thr Pro His Ile Tyr Leu Cys Cys Asp Pro Val Arg Pro Tyr Val Ser 
    210                 215                 220                 


Ala Ala Leu Pro His Ala Val Arg Arg Phe Glu Phe Met Val Met Pro 
225                 230                 235                 240 


Gly Glu Thr Glu Glu Gln Leu Arg Glu Pro Gln Asn Met Arg Lys Leu 
                245                 250                 255     


Leu Ser Lys Val Leu Pro Asn Pro Asp Asn Val Glu Leu Ile Arg Gln 
            260                 265                 270         


Arg Val Tyr Thr His Asn Ala Arg Leu Ala Gln Arg Phe Arg Ile Asp 
        275                 280                 285             


Arg Val Leu Leu Ala Gly Asp Ala Ala His Ile Met Pro Val Trp Gln 
    290                 295                 300                 


Gly Gln Gly Tyr Asn Ser Gly Met Arg Asp Ala Phe Asn Leu Ala Trp 
305                 310                 315                 320 


Lys Leu Ala Leu Val Ile Gln Gly Lys Ala Arg Asp Ala Leu Leu Asp 
                325                 330                 335     


Thr Tyr Gln Gln Glu Arg Arg Asp His Ala Lys Ala Met Ile Asp Leu 
            340                 345                 350         


Ser Val Thr Ala Gly Asn Val Leu Ala Pro Pro Lys Arg Trp Gln Gly 
        355                 360                 365             


Thr Leu Arg Asp Gly Val Ser Trp Leu Leu Asn Tyr Leu Pro Pro Val 
    370                 375                 380                 


Lys Arg Tyr Phe Leu Glu Met Arg Phe Lys Pro Met Pro Gln Tyr Tyr 
385                 390                 395                 400 


Gly Gly Ala Leu Val Arg Glu Gly Glu Ala Lys His Ser Pro Val Gly 
                405                 410                 415     


Lys Met Phe Ile Gln Pro Lys Val Thr Leu Glu Asn Gly Asp Val Thr 
            420                 425                 430         


Leu Leu Asp Asn Ala Ile Gly Ala Asn Phe Ala Val Ile Gly Trp Gly 
        435                 440                 445             


Cys Asn Pro Leu Trp Gly Met Ser Asp Glu Gln Ile Gln Gln Trp Arg 
    450                 455                 460                 


Ala Leu Gly Thr Arg Phe Ile Gln Val Val Pro Glu Val Gln Ile His 
465                 470                 475                 480 


Thr Ala Gln Asp Asn His Asp Gly Val Leu Arg Val Gly Asp Thr Gln 
                485                 490                 495     


Gly Arg Leu Arg Ser Trp Phe Ala Gln His Asn Ala Ser Leu Val Val 
            500                 505                 510         


Met Arg Pro Asp Arg Phe Val Ala Ala Thr Ala Ile Pro Gln Thr Leu 
        515                 520                 525             


Gly Asn Thr Leu Asn Lys Leu Ala Ser Val Met Thr Leu Thr Arg Pro 
    530                 535                 540                 


Asp Ala Asp Val Ser Val Glu Lys Val Ala 
545                 550                 


<210> 25
<211> 315
<212> PRT
<213> Escherichia coli

<400> 25
Met Ile Phe Tyr Cys Ala Leu Ser Ile Gly Arg Val Phe Ser Ala Thr 
1               5                   10                  15      


Ile Lys Thr Cys Pro Asn Val His Gln Val His His Val Val Leu Thr 
            20                  25                  30          


Ile Glu Met Ser Ile Asn Met Gln Asn Asn Glu Gln Thr Glu Tyr Lys 
        35                  40                  45              


Thr Val Arg Gly Leu Thr Arg Gly Leu Met Leu Leu Asn Met Leu Asn 
    50                  55                  60                  


Lys Leu Asp Gly Gly Ala Ser Val Gly Leu Leu Ala Glu Leu Ser Gly 
65                  70                  75                  80  


Leu His Arg Thr Thr Val Arg Arg Leu Leu Glu Thr Leu Gln Glu Glu 
                85                  90                  95      


Gly Tyr Val Arg Arg Ser Pro Ser Asp Asp Ser Phe Arg Leu Thr Ile 
            100                 105                 110         


Lys Val Arg Gln Leu Ser Glu Gly Phe Arg Asp Glu Gln Trp Ile Ser 
        115                 120                 125             


Ala Leu Ala Ala Pro Leu Leu Gly Asp Leu Leu Arg Glu Val Val Trp 
    130                 135                 140                 


Pro Thr Asp Val Ser Thr Leu Asp Val Asp Ala Met Val Val Arg Glu 
145                 150                 155                 160 


Thr Thr His Arg Phe Ser Arg Leu Ser Phe His Arg Ala Met Val Gly 
                165                 170                 175     


Arg Arg Leu Pro Leu Leu Lys Thr Ala Ser Gly Leu Thr Trp Leu Ala 
            180                 185                 190         


Phe Cys Pro Glu Gln Asp Arg Lys Glu Leu Ile Glu Met Leu Ala Ser 
        195                 200                 205             


Arg Pro Gly Asp Asp Tyr Gln Leu Ala Arg Glu Pro Leu Lys Leu Glu 
    210                 215                 220                 


Ala Ile Leu Ala Arg Ala Arg Lys Glu Gly Tyr Gly Gln Asn Tyr Arg 
225                 230                 235                 240 


Gly Trp Asp Gln Glu Glu Lys Ile Ala Ser Ile Ala Val Pro Leu Arg 
                245                 250                 255     


Ser Glu Gln Arg Val Ile Gly Cys Leu Asn Leu Val Tyr Met Ala Ser 
            260                 265                 270         


Ala Met Thr Ile Glu Gln Ala Ala Glu Lys His Leu Pro Ala Leu Gln 
        275                 280                 285             


Arg Val Ala Lys Gln Ile Glu Glu Gly Val Glu Ser Gln Ala Ile Leu 
    290                 295                 300                 


Val Ala Gly Arg Arg Ser Gly Met His Leu Arg 
305                 310                 315 


<210> 26
<211> 360
<212> PRT
<213> Escherichia coli

<400> 26
Met Lys Pro Val Thr Leu Tyr Asp Val Ala Glu Tyr Ala Gly Val Ser 
1               5                   10                  15      


Tyr Gln Thr Val Ser Arg Val Val Asn Gln Ala Ser His Val Ser Ala 
            20                  25                  30          


Lys Thr Arg Glu Lys Val Glu Ala Ala Met Ala Glu Leu Asn Tyr Ile 
        35                  40                  45              


Pro Asn Arg Val Ala Gln Gln Leu Ala Gly Lys Gln Ser Leu Leu Ile 
    50                  55                  60                  


Gly Val Ala Thr Ser Ser Leu Ala Leu His Ala Pro Ser Gln Ile Val 
65                  70                  75                  80  


Ala Ala Ile Lys Ser Arg Ala Asp Gln Leu Gly Ala Ser Val Val Val 
                85                  90                  95      


Ser Met Val Glu Arg Ser Gly Val Glu Ala Cys Lys Ala Ala Val His 
            100                 105                 110         


Asn Leu Leu Ala Gln Arg Val Ser Gly Leu Ile Ile Asn Tyr Pro Leu 
        115                 120                 125             


Asp Asp Gln Asp Ala Ile Ala Val Glu Ala Ala Cys Thr Asn Val Pro 
    130                 135                 140                 


Ala Leu Phe Leu Asp Val Ser Asp Gln Thr Pro Ile Asn Ser Ile Ile 
145                 150                 155                 160 


Phe Ser His Glu Asp Gly Thr Arg Leu Gly Val Glu His Leu Val Ala 
                165                 170                 175     


Leu Gly His Gln Gln Ile Ala Leu Leu Ala Gly Pro Leu Ser Ser Val 
            180                 185                 190         


Ser Ala Arg Leu Arg Leu Ala Gly Trp His Lys Tyr Leu Thr Arg Asn 
        195                 200                 205             


Gln Ile Gln Pro Ile Ala Glu Arg Glu Gly Asp Trp Ser Ala Met Ser 
    210                 215                 220                 


Gly Phe Gln Gln Thr Met Gln Met Leu Asn Glu Gly Ile Val Pro Thr 
225                 230                 235                 240 


Ala Met Leu Val Ala Asn Asp Gln Met Ala Leu Gly Ala Met Arg Ala 
                245                 250                 255     


Ile Thr Glu Ser Gly Leu Arg Val Gly Ala Asp Ile Ser Val Val Gly 
            260                 265                 270         


Tyr Asp Asp Thr Glu Asp Ser Ser Cys Tyr Ile Pro Pro Leu Thr Thr 
        275                 280                 285             


Ile Lys Gln Asp Phe Arg Leu Leu Gly Gln Thr Ser Val Asp Arg Leu 
    290                 295                 300                 


Leu Gln Leu Ser Gln Gly Gln Ala Val Lys Gly Asn Gln Leu Leu Pro 
305                 310                 315                 320 


Val Ser Leu Val Lys Arg Lys Thr Thr Leu Ala Pro Asn Thr Gln Thr 
                325                 330                 335     


Ala Ser Pro Arg Ala Leu Ala Asp Ser Leu Met Gln Leu Ala Arg Gln 
            340                 345                 350         


Val Ser Arg Leu Glu Ser Gly Gln 
        355                 360 


<210> 27
<211> 353
<212> PRT
<213> Escherichia coli

<400> 27
Met Ala Ile Asp Glu Asn Lys Gln Lys Ala Leu Ala Ala Ala Leu Gly 
1               5                   10                  15      


Gln Ile Glu Lys Gln Phe Gly Lys Gly Ser Ile Met Arg Leu Gly Glu 
            20                  25                  30          


Asp Arg Ser Met Asp Val Glu Thr Ile Ser Thr Gly Ser Leu Ser Leu 
        35                  40                  45              


Asp Ile Ala Leu Gly Ala Gly Gly Leu Pro Met Gly Arg Ile Val Glu 
    50                  55                  60                  


Ile Tyr Gly Pro Glu Ser Ser Gly Lys Thr Thr Leu Thr Leu Gln Val 
65                  70                  75                  80  


Ile Ala Ala Ala Gln Arg Glu Gly Lys Thr Cys Ala Phe Ile Asp Ala 
                85                  90                  95      


Glu His Ala Leu Asp Pro Ile Tyr Ala Arg Lys Leu Gly Val Asp Ile 
            100                 105                 110         


Asp Asn Leu Leu Cys Ser Gln Pro Asp Thr Gly Glu Gln Ala Leu Glu 
        115                 120                 125             


Ile Cys Asp Ala Leu Ala Arg Ser Gly Ala Val Asp Val Ile Val Val 
    130                 135                 140                 


Asp Ser Val Ala Ala Leu Thr Pro Lys Ala Glu Ile Glu Gly Glu Ile 
145                 150                 155                 160 


Gly Asp Ser His Met Gly Leu Ala Ala Arg Met Met Ser Gln Ala Met 
                165                 170                 175     


Arg Lys Leu Ala Gly Asn Leu Lys Gln Ser Asn Thr Leu Leu Ile Phe 
            180                 185                 190         


Ile Asn Gln Ile Arg Met Lys Ile Gly Val Met Phe Gly Asn Pro Glu 
        195                 200                 205             


Thr Thr Thr Gly Gly Asn Ala Leu Lys Phe Tyr Ala Ser Val Arg Leu 
    210                 215                 220                 


Asp Ile Arg Arg Ile Gly Ala Val Lys Glu Gly Glu Asn Val Val Gly 
225                 230                 235                 240 


Ser Glu Thr Arg Val Lys Val Val Lys Asn Lys Ile Ala Ala Pro Phe 
                245                 250                 255     


Lys Gln Ala Glu Phe Gln Ile Leu Tyr Gly Glu Gly Ile Asn Phe Tyr 
            260                 265                 270         


Gly Glu Leu Val Asp Leu Gly Val Lys Glu Lys Leu Ile Glu Lys Ala 
        275                 280                 285             


Gly Ala Trp Tyr Ser Tyr Lys Gly Glu Lys Ile Gly Gln Gly Lys Ala 
    290                 295                 300                 


Asn Ala Thr Ala Trp Leu Lys Asp Asn Pro Glu Thr Ala Lys Glu Ile 
305                 310                 315                 320 


Glu Lys Lys Val Arg Glu Leu Leu Leu Ser Asn Pro Asn Ser Thr Pro 
                325                 330                 335     


Asp Phe Ser Val Asp Asp Ser Glu Gly Val Ala Glu Thr Asn Glu Asp 
            340                 345                 350         


Phe 
    


<210> 28
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
ctgtataaaa ccacagccaa tcaaacgaaa ccaggctata ctcaagcct                   49


<210> 29
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
ttttataaat acacagccaa tcaaacgaaa ccaggctata ctcaagcct                   49


<210> 30
<211> 133
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 30
ctcagcggtg gcagcagcct aggttaacta cttttctttg ttggtctttg cctccatttt       60

gtcggcctgg taatgactcc aacttattga tagtgtttta tgttcagata atgcccgatg      120

actttgtcat gca                                                         133


<210> 31
<211> 133
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (22)..(22)
<223> a, c, t, g, unknown or other

<400> 31
ctcagcggtg gcagcagcct angttaatca tttttctttg ttggttttgg cttccatttt       60

atctgcttgg taatgactcc aacttattga tagtgtttta tgttcagata atgcccgatg      120

actttgtcat gca                                                         133


<210> 32
<211> 133
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
ctcagcggtg gcagcagcct aggttaatca tttttctttg ttggttttgg cttccatttt       60

atctgcttgg taatgactcc aacttattga tagtgtttta tgttcagata atgcccgatg      120

actttgtcat gca                                                         133


