                         SEQUENCE LISTING

<110>  Alpine Immune Sciences, Inc.
       SWANSON, Ryan
 
<120>  MULTI-DOMAIN IMMUNOMODULATORY PROTEINS AND METHODS OF USE THEREOF

<130>  761612000740

<140> Not Yet Assigned    
<141> Concurrently Herewith

<150>  62/613,378
<151>  2018-01-03

<150>  62/733,622
<151>  2018-09-19

<160>  3688  

<170>  PatentIn version 3.5

<210>  1
<211>  288
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD80(B7-1)

<400>  1

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210>  2
<211>  329
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD86(B7-2)

<400>  2

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     


Asn Ser Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 


<210>  3
<211>  290
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD274 (PD-L1, B7-H1)

<400>  3

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  4
<211>  273
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PDCD1LG2(PD-L2, CD273)

<400>  4

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    


<210>  5
<211>  302
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  ICOSLG(B7RP1, CD275, ICOSL, B7-H2)

<400>  5

Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu 
1               5                   10                  15      


Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
            20                  25                  30          


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
        35                  40                  45              


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
    50                  55                  60                  


Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
65                  70                  75                  80  


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
                85                  90                  95      


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
            100                 105                 110         


Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
        115                 120                 125             


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser 
    130                 135                 140                 


Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser 
145                 150                 155                 160 


Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp 
                165                 170                 175     


Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn 
            180                 185                 190         


Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr 
        195                 200                 205             


Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln 
    210                 215                 220                 


Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
225                 230                 235                 240 


Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
                245                 250                 255     


Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala 
            260                 265                 270         


Ile Gly Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly 
        275                 280                 285             


Ala Trp Ala Val Ser Pro Glu Thr Glu Leu Thr Gly His Val 
    290                 295                 300         


<210>  6
<211>  534
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD276(B7-H3)

<400>  6

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 
225                 230                 235                 240 


Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 
                245                 250                 255     


Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 
            260                 265                 270         


Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 
        275                 280                 285             


Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 
    290                 295                 300                 


Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 
305                 310                 315                 320 


Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 
                325                 330                 335     


Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 
            340                 345                 350         


Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 
        355                 360                 365             


Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 
    370                 375                 380                 


Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 
385                 390                 395                 400 


Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 
                405                 410                 415     


Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 
            420                 425                 430         


Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 
        435                 440                 445             


Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 
    450                 455                 460                 


Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 
                485                 490                 495     


Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 
            500                 505                 510         


Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp 
        515                 520                 525             


Asp Gly Gln Glu Ile Ala 
    530                 


<210>  7
<211>  282
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  VTCN1(B7-H4)

<400>  7

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  8
<211>  220
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD28

<400>  8

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  9
<211>  223
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CTLA4

<400>  9

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  10
<211>  288
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PDCD1(PD-1)

<400>  10

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  11
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  ICOS

<400>  11

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  12
<211>  289
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  BTLA(CD272)

<400>  12

Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu Leu Pro 
145                 150                 155                 160 


Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys 
                165                 170                 175     


Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
            180                 185                 190         


Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
        195                 200                 205             


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 
    210                 215                 220                 


Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
225                 230                 235                 240 


Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
                245                 250                 255     


Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala 
            260                 265                 270         


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
        275                 280                 285             


Ser 
    


<210>  13
<211>  458
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD4

<400>  13

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210>  14
<211>  235
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD8A(CD8-alpha)

<400>  14

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  15
<211>  210
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD8B(CD8-beta)

<400>  15

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe 
        195                 200                 205             


Tyr Lys 
    210 


<210>  16
<211>  525
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  LAG3

<400>  16

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  17
<211>  301
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HAVCR2(TIM-3)

<400>  17

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210>  18
<211>  526
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CEACAM1

<400>  18

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg 
    450                 455                 460                 


Asp Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His 
465                 470                 475                 480 


Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu 
                485                 490                 495     


Asn Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser 
            500                 505                 510         


Leu Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
        515                 520                 525     


<210>  19
<211>  244
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TIGIT

<400>  19

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     


Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         


Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             


Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 


Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 


Thr Glu Thr Gly 
                


<210>  20
<211>  417
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PVR(CD155)

<400>  20

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Ile Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
            340                 345                 350         


Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
        355                 360                 365             


Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
    370                 375                 380                 


Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala 
385                 390                 395                 400 


Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr 
                405                 410                 415     


Arg 
    


<210>  21
<211>  538
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PVRL2(CD112)

<400>  21

Met Ala Arg Ala Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro 
1               5                   10                  15      


Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr 
    50                  55                  60                  


Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln 
65                  70                  75                  80  


Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro 
                85                  90                  95      


Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr 
            100                 105                 110         


Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His 
        115                 120                 125             


Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr 
    130                 135                 140                 


Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala 
145                 150                 155                 160 


Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp 
                165                 170                 175     


Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala 
            180                 185                 190         


Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln 
        195                 200                 205             


Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr 
    210                 215                 220                 


Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val 
225                 230                 235                 240 


Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser 
                245                 250                 255     


Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp 
            260                 265                 270         


Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn 
        275                 280                 285             


Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro 
    290                 295                 300                 


Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp 
305                 310                 315                 320 


Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly 
                325                 330                 335     


Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn Thr 
            340                 345                 350         


Ala Gly Ala Gly Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala Ala 
        355                 360                 365             


Ile Ile Ala Thr Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg Gln 
    370                 375                 380                 


Gln Arg Lys Glu Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp Leu 
385                 390                 395                 400 


Glu Gly Pro Pro Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu Glu 
                405                 410                 415     


Ala Gln Glu Met Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu His 
            420                 425                 430         


Ser Pro Leu Lys Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr Glu 
        435                 440                 445             


Gln Glu Met Pro Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg Ser 
    450                 455                 460                 


Gly Pro Leu His Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro Val 
465                 470                 475                 480 


Pro Pro Gly Pro Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu Asp 
                485                 490                 495     


Glu Glu Gly Glu Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro Ile 
            500                 505                 510         


Tyr Asp Ala Leu Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly Lys 
        515                 520                 525             


Gly Phe Val Met Ser Arg Ala Met Tyr Val 
    530                 535             


<210>  22
<211>  336
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD226

<400>  22

Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val 
225                 230                 235                 240 


Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr 
        275                 280                 285             


Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile 
    290                 295                 300                 


Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp 
305                 310                 315                 320 


Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
                325                 330                 335     


<210>  23
<211>  351
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD2

<400>  23

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
                245                 250                 255     


Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr 
            260                 265                 270         


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
            340                 345                 350     


<210>  24
<211>  180
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD160

<400>  24

Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Thr Ser Ser 
            20                  25                  30          


Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu Ile Cys Thr Val Trp His 
        35                  40                  45              


Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg 
    50                  55                  60                  


Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu Lys Gln Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met 
                85                  90                  95      


Phe Thr Ile Ser Gln Val Thr Pro Leu His Ser Gly Thr Tyr Gln Cys 
            100                 105                 110         


Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe 
        115                 120                 125             


Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr Thr Val Thr Gly Leu Lys 
    130                 135                 140                 


Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr Leu Ser Ser 
145                 150                 155                 160 


Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val 
                165                 170                 175     


Ala Leu Gln Ala 
            180 


<210>  25
<211>  278
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD200

<400>  25

Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg 
                165                 170                 175     


Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 
    210                 215                 220                 


Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro Leu Leu 
225                 230                 235                 240 


Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu 
                245                 250                 255     


Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Gly Glu Leu Ser Gln 
            260                 265                 270         


Gly Val Gln Lys Met Thr 
        275             


<210>  26
<211>  325
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD200R1(CD200R)

<400>  26

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Ala Ser Ser Ser Leu Cys Met Asp Glu Lys 
            20                  25                  30          


Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu Val Asn Thr Ser 
        35                  40                  45              


Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys Cys Pro Pro Ile 
    50                  55                  60                  


Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile Ile Leu Arg Gly 
65                  70                  75                  80  


Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr Asn Glu Thr Lys 
                85                  90                  95      


Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val Ser Arg Pro Asp 
            100                 105                 110         


Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile Thr His Asp Gly 
        115                 120                 125             


Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn Phe His Arg Gly 
    130                 135                 140                 


Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr Leu Phe Gln Asn 
145                 150                 155                 160 


Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly Lys Pro Ala Ala 
                165                 170                 175     


Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr Lys Gln Glu Tyr 
            180                 185                 190         


Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys His Trp Glu Val 
        195                 200                 205             


His Asn Val Ser Thr Val Thr Cys His Val Ser His Leu Thr Gly Asn 
    210                 215                 220                 


Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly Ala Lys Lys Ser 
225                 230                 235                 240 


Ala Lys Leu Tyr Ile Pro Tyr Ile Ile Leu Thr Ile Ile Ile Leu Thr 
                245                 250                 255     


Ile Val Gly Phe Ile Trp Leu Leu Lys Val Asn Gly Cys Arg Lys Tyr 
            260                 265                 270         


Lys Leu Asn Lys Thr Glu Ser Thr Pro Val Val Glu Glu Asp Glu Met 
        275                 280                 285             


Gln Pro Tyr Ala Ser Tyr Thr Glu Lys Asn Asn Pro Leu Tyr Asp Thr 
    290                 295                 300                 


Thr Asn Lys Val Lys Ala Ser Glu Ala Leu Gln Ser Glu Val Asp Thr 
305                 310                 315                 320 


Asp Leu His Thr Leu 
                325 


<210>  27
<211>  201
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  NC R3 (NKp30)

<400>  27

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala 
    130                 135                 140                 


Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg Gln Leu 
                165                 170                 175     


Pro Ala Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser Ser Ala 
            180                 185                 190         


His Leu Leu Pro Pro Val Pro Gly Gly 
        195                 200     


<210>  28
<211>  208
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD80(B7-1) ECD

<400>  28

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  29
<211>  224
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD86(B7-2) ECD

<400>  29

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


<210>  30
<211>  220
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD274 (PD-L1, B7-H1) ECD

<400>  30

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  31
<211>  201
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PDCD1LG2(PD-L2, CD273) ECD

<400>  31

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  32
<211>  238
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  ICOSLG(B7RP1, CD275, ICOSL, B7-H2) ECD

<400>  32

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  33
<211>  438
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD276(B7-H3) ECD

<400>  33

Leu Glu Val Gln Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr 
1               5                   10                  15      


Asp Ala Thr Leu Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu 
            20                  25                  30          


Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val 
        35                  40                  45              


His Ser Phe Ala Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg 
    50                  55                  60                  


Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg 
65                  70                  75                  80  


Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val 
                85                  90                  95      


Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala 
            100                 105                 110         


Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg 
        115                 120                 125             


Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro 
    130                 135                 140                 


Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly 
145                 150                 155                 160 


Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val 
                165                 170                 175     


His Ser Ile Leu Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys 
            180                 185                 190         


Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr 
        195                 200                 205             


Ile Thr Pro Gln Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro 
    210                 215                 220                 


Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys 
225                 230                 235                 240 


Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile 
                245                 250                 255     


Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly 
            260                 265                 270         


Arg Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp 
        275                 280                 285             


Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val 
    290                 295                 300                 


Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly 
305                 310                 315                 320 


Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser 
                325                 330                 335     


Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr 
            340                 345                 350         


Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp 
        355                 360                 365             


Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln 
    370                 375                 380                 


Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val 
385                 390                 395                 400 


Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val 
                405                 410                 415     


Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met 
            420                 425                 430         


Thr Phe Pro Pro Glu Ala 
        435             


<210>  34
<211>  235
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  VTCN1(B7-H4) ECD

<400>  34

Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
1               5                   10                  15      


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
            20                  25                  30          


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
        35                  40                  45              


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
    50                  55                  60                  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
65                  70                  75                  80  


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
                85                  90                  95      


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
            100                 105                 110         


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
        115                 120                 125             


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
    130                 135                 140                 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
145                 150                 155                 160 


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
                165                 170                 175     


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
            180                 185                 190         


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
        195                 200                 205             


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
    210                 215                 220                 


Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser 
225                 230                 235 


<210>  35
<211>  134
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD28 ECD

<400>  35

Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn 
1               5                   10                  15      


Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
            20                  25                  30          


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
        35                  40                  45              


Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr 
    50                  55                  60                  


Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile 
                85                  90                  95      


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
            100                 105                 110         


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
        115                 120                 125             


Pro Gly Pro Ser Lys Pro 
    130                 


<210>  36
<211>  126
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CTLA4 ECD

<400>  36

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  37
<211>  150
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PDCD1(PD-1) ECD

<400>  37

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  38
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  ICOS ECD

<400>  38

Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile Phe His Asn Gly 
1               5                   10                  15      


Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val Gln Gln Phe Lys 
            20                  25                  30          


Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp Leu Thr Lys Thr 
        35                  40                  45              


Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu Lys Phe Cys His 
    50                  55                  60                  


Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Tyr Asn Leu Asp 
65                  70                  75                  80  


His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser Ile Phe Asp Pro 
                85                  90                  95      


Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu His Ile Tyr Glu 
            100                 105                 110         


Ser Gln Leu Cys Cys Gln Leu Lys 
        115                 120 


<210>  39
<211>  127
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  BTLA(CD272) ECD

<400>  39

Lys Glu Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His 
1               5                   10                  15      


Ser Ile Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr 
            20                  25                  30          


Cys Ala Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr 
        35                  40                  45              


Cys Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn 
    50                  55                  60                  


Ile Ser Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn 
65                  70                  75                  80  


Gly Ser Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser 
                85                  90                  95      


His Ser Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg 
            100                 105                 110         


Pro Ser Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg 
        115                 120                 125         


<210>  40
<211>  371
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD4 ECD

<400>  40

Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys 
1               5                   10                  15      


Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn 
            20                  25                  30          


Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro 
        35                  40                  45              


Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln 
    50                  55                  60                  


Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp 
65                  70                  75                  80  


Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu 
                85                  90                  95      


Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln 
            100                 105                 110         


Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val 
        115                 120                 125             


Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu 
    130                 135                 140                 


Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr 
145                 150                 155                 160 


Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val 
                165                 170                 175     


Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu 
            180                 185                 190         


Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr 
        195                 200                 205             


Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys 
    210                 215                 220                 


Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg 
225                 230                 235                 240 


Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His 
                245                 250                 255     


Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu 
            260                 265                 270         


Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn 
        275                 280                 285             


Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu 
    290                 295                 300                 


Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu Lys Leu Glu 
305                 310                 315                 320 


Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val Trp Val Leu 
                325                 330                 335     


Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp Ser Gly Gln 
            340                 345                 350         


Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro 
        355                 360                 365             


Val Gln Pro 
    370     


<210>  41
<211>  161
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD8A(CD8-alpha) ECD

<400>  41

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        115                 120                 125             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    130                 135                 140                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
145                 150                 155                 160 


Asp 
    


<210>  42
<211>  149
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD8B(CD8-beta) ECD

<400>  42

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro 
145                 


<210>  43
<211>  422
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  LAG3 ECD

<400>  43

Val Pro Val Val Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys 
1               5                   10                  15      


Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly 
            20                  25                  30          


Val Thr Trp Gln His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro 
        35                  40                  45              


Gly His Pro Leu Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp 
    50                  55                  60                  


Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly 
65                  70                  75                  80  


Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu 
                85                  90                  95      


Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg 
            100                 105                 110         


Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg 
        115                 120                 125             


Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr 
    130                 135                 140                 


Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn 
145                 150                 155                 160 


Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg 
                165                 170                 175     


Asn Arg Gly Gln Gly Arg Val Pro Val Arg Glu Ser Pro His His His 
            180                 185                 190         


Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser 
        195                 200                 205             


Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser 
    210                 215                 220                 


Ile Met Tyr Asn Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu 
225                 230                 235                 240 


Thr Val Tyr Ala Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu 
                245                 250                 255     


Pro Ala Gly Val Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro 
            260                 265                 270         


Pro Gly Gly Gly Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe 
        275                 280                 285             


Thr Leu Arg Leu Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr 
    290                 295                 300                 


Cys His Ile His Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu 
305                 310                 315                 320 


Ala Ile Ile Thr Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu 
                325                 330                 335     


Gly Lys Leu Leu Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe 
            340                 345                 350         


Val Trp Ser Ser Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro 
        355                 360                 365             


Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys 
    370                 375                 380                 


Gln Leu Tyr Gln Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr 
385                 390                 395                 400 


Glu Leu Ser Ser Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala 
                405                 410                 415     


Leu Pro Ala Gly His Leu 
            420         


<210>  44
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HAVCR2(TIM-3) ECD

<400>  44

Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp 
            20                  25                  30          


Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg 
        35                  40                  45              


Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn 
    50                  55                  60                  


Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr 
65                  70                  75                  80  


Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile 
                85                  90                  95      


Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys 
            100                 105                 110         


Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro 
        115                 120                 125             


Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu 
    130                 135                 140                 


Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn 
145                 150                 155                 160 


Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala 
                165                 170                 175     


Thr Ile Arg Ile Gly 
            180     


<210>  45
<211>  394
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CEACAM1 ECD

<400>  45

Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val Gly Tyr 
        35                  40                  45              


Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Thr 
                165                 170                 175     


Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn Arg Ser 
            180                 185                 190         


Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro Thr Ile 
        195                 200                 205             


Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser Leu Ser 
    210                 215                 220                 


Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser Val Thr 
            260                 265                 270         


Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu Leu Ser 
        275                 280                 285             


Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr Val Thr 
    290                 295                 300                 


Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp Thr Gly 
305                 310                 315                 320 


Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser Ser Glu 
                325                 330                 335     


Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn Pro Val 
            340                 345                 350         


Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn Pro Ile 
        355                 360                 365             


Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr Asn Ala 
    370                 375                 380                 


Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly 
385                 390                 


<210>  46
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TIGIT ECD

<400>  46

Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro 
        115                 120 


<210>  47
<211>  323
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PVR(CD155) ECD

<400>  47

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  48
<211>  329
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PVRL2(CD112) ECD

<400>  48

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  49
<211>  236
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD226 ECD

<400>  49

Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn Met Ser 
1               5                   10                  15      


Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val Glu Trp 
            20                  25                  30          


Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser Pro Thr 
        35                  40                  45              


His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr Phe Leu 
    50                  55                  60                  


Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg Asn Ala 
65                  70                  75                  80  


Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr Tyr Pro 
                85                  90                  95      


Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp Ser Phe 
            100                 105                 110         


Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro Gly Lys 
        115                 120                 125             


Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val Gln Ala 
    130                 135                 140                 


Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu Thr Tyr 
145                 150                 155                 160 


Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro Arg Gln 
                165                 170                 175     


Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val Ile Pro 
            180                 185                 190         


Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu Gln Ala 
        195                 200                 205             


Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val Ala Glu 
    210                 215                 220                 


Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala 
225                 230                 235     


<210>  50
<211>  185
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD2 ECD

<400>  50

Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly Ala Leu Gly Gln Asp 
1               5                   10                  15      


Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser Asp Asp Ile Asp Asp 
            20                  25                  30          


Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys Ile Ala Gln Phe Arg 
        35                  40                  45              


Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr Tyr Lys Leu Phe Lys 
    50                  55                  60                  


Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr Asp Asp Gln Asp Ile 
65                  70                  75                  80  


Tyr Lys Val Ser Ile Tyr Asp Thr Lys Gly Lys Asn Val Leu Glu Lys 
                85                  90                  95      


Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser 
            100                 105                 110         


Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu Val Met Asn Gly Thr 
        115                 120                 125             


Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys His Leu Lys Leu Ser 
    130                 135                 140                 


Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser Leu Ser Ala Lys Phe 
145                 150                 155                 160 


Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu Ser Ser Val Glu Pro 
                165                 170                 175     


Val Ser Cys Pro Glu Lys Gly Leu Asp 
            180                 185 


<210>  51
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD160 ECD

<400>  51

Ile Asn Ile Thr Ser Ser Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu 
1               5                   10                  15      


Ile Cys Thr Val Trp His Lys Lys Glu Glu Ala Glu Gly Phe Val Val 
            20                  25                  30          


Phe Leu Cys Lys Asp Arg Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu 
        35                  40                  45              


Lys Gln Leu Arg Leu Lys Arg Asp Pro Gly Ile Asp Gly Val Gly Glu 
    50                  55                  60                  


Ile Ser Ser Gln Leu Met Phe Thr Ile Ser Gln Val Thr Pro Leu His 
65                  70                  75                  80  


Ser Gly Thr Tyr Gln Cys Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg 
                85                  90                  95      


Leu Gln Gly His Phe Phe Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr 
            100                 105                 110         


Thr Val Thr Gly Leu Lys Gln Arg Gln His Leu Glu Phe Ser His Asn 
        115                 120                 125             


Glu Gly Thr Leu Ser 
    130             


<210>  52
<211>  202
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD200 ECD

<400>  52

Gln Val Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro 
1               5                   10                  15      


Ala Ser Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val 
            20                  25                  30          


Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe 
        35                  40                  45              


Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile 
    50                  55                  60                  


Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn 
65                  70                  75                  80  


Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe 
                85                  90                  95      


Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln 
            100                 105                 110         


Pro Ile Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile 
        115                 120                 125             


Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val 
    130                 135                 140                 


Pro Arg Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn 
145                 150                 155                 160 


Gly Thr Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn 
                165                 170                 175     


Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val 
            180                 185                 190         


Thr Asp Phe Lys Gln Thr Val Asn Lys Gly 
        195                 200         


<210>  53
<211>  215
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD200R1(CD200R) ECD

<400>  53

Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu 
1               5                   10                  15      


Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys 
            20                  25                  30          


Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile 
        35                  40                  45              


Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr 
    50                  55                  60                  


Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val 
65                  70                  75                  80  


Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile 
                85                  90                  95      


Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn 
            100                 105                 110         


Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr 
        115                 120                 125             


Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly 
    130                 135                 140                 


Lys Pro Ala Ala Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr 
145                 150                 155                 160 


Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys 
                165                 170                 175     


His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His Val Ser His 
            180                 185                 190         


Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly 
        195                 200                 205             


Ala Lys Lys Ser Ala Lys Leu 
    210                 215 


<210>  54
<211>  117
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  NC R3 (NKp30) ECD

<400>  54

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         


His Pro Gln Leu Gly 
        115         


<210>  55
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV

<400>  55

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  56
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v1

<400>  56

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Asn Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val Asn Gly Glu Glu Asp Leu Glu Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  57
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v2

<400>  57

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Thr Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  58
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v3

<400>  58

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Glu Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  59
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v4

<400>  59

Phe Thr Val Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Thr Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  60
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v5

<400>  60

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  61
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v6

<400>  61

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  62
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v7

<400>  62

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  63
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v8

<400>  63

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  64
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v9

<400>  64

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  65
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v10

<400>  65

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  66
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v11

<400>  66

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  67
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v12

<400>  67

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asp Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Gly Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  68
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v13

<400>  68

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Ser Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  69
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v14

<400>  69

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  70
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v15

<400>  70

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  71
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v16

<400>  71

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  72
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v17

<400>  72

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  73
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v18

<400>  73

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  74
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v19

<400>  74

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Glu Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  75
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v20

<400>  75

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Ile Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val Arg Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  76
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v21

<400>  76

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Glu Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln Arg Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  77
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v22

<400>  77

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  78
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v23

<400>  78

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Gly 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Glu Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  79
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v24

<400>  79

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  80
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v25

<400>  80

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  81
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v26

<400>  81

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Val Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  82
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v27

<400>  82

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  83
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v28

<400>  83

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Gly Met Glu Val Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  84
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v29

<400>  84

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Ser Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  85
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v30

<400>  85

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  86
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v31

<400>  86

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  87
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v32

<400>  87

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  88
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v33

<400>  88

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  89
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v34

<400>  89

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  90
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v35

<400>  90

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  91
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v36

<400>  91

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Met Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  92
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v37

<400>  92

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  93
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v38

<400>  93

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Pro Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  94
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v39

<400>  94

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  95
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v40

<400>  95

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Arg Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  96
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v41

<400>  96

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  97
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v42

<400>  97

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Val Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  98
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v43

<400>  98

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Gly Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  99
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v44

<400>  99

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  100
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v45

<400>  100

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  101
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v46

<400>  101

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  102
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v47

<400>  102

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  103
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v48

<400>  103

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  104
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v49

<400>  104

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  105
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v50

<400>  105

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  106
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v51

<400>  106

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  107
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v52

<400>  107

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Ala Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val Tyr Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  108
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v53

<400>  108

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  109
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v54

<400>  109

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  110
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v55

<400>  110

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  111
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v56

<400>  111

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Gly Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  112
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v57

<400>  112

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  113
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v58

<400>  113

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  114
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v59

<400>  114

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Gly Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Asp Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  115
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v60

<400>  115

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp 
        115                 120                 125             


Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro 
    130                 135                 140                 


Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly 
145                 150                 155                 160 


Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val 
                165                 170                 175     


Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys 
            180                 185                 190         


Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val 
        195                 200                 205             


Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220     


<210>  116
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v61

<400>  116

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  117
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v62

<400>  117

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  118
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v63

<400>  118

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Ile Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Ile Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Lys Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  119
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v64

<400>  119

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  120
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v65

<400>  120

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  121
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v1

<400>  121

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Asn Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln Phe Val Asn Gly Glu 
        35                  40                  45              


Glu Asp Leu Glu Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  122
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v2

<400>  122

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Thr Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asp Ile Thr Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  123
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v3

<400>  123

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Lys Glu Asp Glu Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  124
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v4

<400>  124

Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Thr Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  125
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v5

<400>  125

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  126
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v6

<400>  126

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  127
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v7

<400>  127

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  128
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v8

<400>  128

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  129
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v9

<400>  129

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  130
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v10

<400>  130

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  131
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v11

<400>  131

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Thr Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  132
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v12

<400>  132

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asp Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Gly Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  133
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v13

<400>  133

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Ser Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  134
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v14

<400>  134

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  135
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v15

<400>  135

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  136
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v16

<400>  136

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  137
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v17

<400>  137

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  138
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v18

<400>  138

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Lys Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  139
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v19

<400>  139

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Glu 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  140
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v20

<400>  140

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Ile Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Lys Glu Gly Lys Asn Ile Ile Gln Phe Val Arg Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  141
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v21

<400>  141

Pro Lys Asp Leu Tyr Glu Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Thr Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln Arg Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  142
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v22

<400>  142

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Ala His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  143
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v23

<400>  143

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Gly Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Glu Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  144
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v24

<400>  144

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Ile Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  145
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v25

<400>  145

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  146
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v26

<400>  146

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Val 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  147
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v27

<400>  147

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  148
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v28

<400>  148

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Gly Met Glu Val Lys Thr Ile Ile Gln Phe Ala His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  149
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v29

<400>  149

Pro Lys Asp Leu Tyr Val Val Glu Ser Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  150
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v30

<400>  150

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  151
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v31

<400>  151

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  152
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v32

<400>  152

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  153
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v33

<400>  153

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  154
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v34

<400>  154

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  155
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v35

<400>  155

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  156
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v36

<400>  156

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Met Lys Val 
            100                 105         


<210>  157
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v37

<400>  157

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Thr Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  158
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v38

<400>  158

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Pro Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  159
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v39

<400>  159

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  160
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v40

<400>  160

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Arg Arg Ile Thr Val Lys Val 
            100                 105         


<210>  161
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v41

<400>  161

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  162
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v42

<400>  162

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Val Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  163
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v43

<400>  163

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Gly Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  164
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v44

<400>  164

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  165
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v45

<400>  165

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  166
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v46

<400>  166

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  167
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v47

<400>  167

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  168
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v48

<400>  168

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  169
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v49

<400>  169

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  170
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v50

<400>  170

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  171
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v51

<400>  171

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  172
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v52

<400>  172

Pro Lys Asp Leu Tyr Ala Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val Tyr Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Gly Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  173
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v53

<400>  173

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Thr Ile Ile Gln Phe Ala His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  174
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v54

<400>  174

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  175
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v55

<400>  175

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Thr Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  176
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v56

<400>  176

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Gly 
        35                  40                  45              


Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  177
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v57

<400>  177

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  178
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v58

<400>  178

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  179
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v59

<400>  179

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Gly Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Asp 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  180
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v60

<400>  180

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105             


<210>  181
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v61

<400>  181

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  182
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v62

<400>  182

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Ala His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  183
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v63

<400>  183

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Ile Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Ile Ile Ile Gln Phe Ala His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Lys Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  184
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v64

<400>  184

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  185
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v65

<400>  185

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  186
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH signal peptide

<400>  186

Met Gly Ser Thr Ala Ile Leu Ala Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Ser Ala 
            


<210>  187
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc

<400>  187

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  188
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG2 Fc

<400>  188

Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
1               5                   10                  15      


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235 


<210>  189
<211>  254
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD80(B7-1)

<400>  189

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe 
    210                 215                 220                 


Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg 
225                 230                 235                 240 


Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
                245                 250                 


<210>  190
<211>  306
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD86(B7-2)

<400>  190

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val Phe 
225                 230                 235                 240 


Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys Arg Pro Arg Asn Ser 
                245                 250                 255     


Tyr Lys Cys Gly Thr Asn Thr Met Glu Arg Glu Glu Ser Glu Gln Thr 
            260                 265                 270         


Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln 
        275                 280                 285             


Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr 
    290                 295                 300                 


Cys Phe 
305     


<210>  191
<211>  272
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD274 (PD-L1, B7-H1)

<400>  191

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val 
    210                 215                 220                 


Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile 
225                 230                 235                 240 


Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile 
                245                 250                 255     


Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr 
            260                 265                 270         


<210>  192
<211>  254
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature PDCD1LG2(PD-L2, CD273)

<400>  192

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His Ile Phe Ile 
        195                 200                 205             


Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val Ile Ala Leu 
    210                 215                 220                 


Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp Thr Thr Lys 
225                 230                 235                 240 


Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala Ile 
                245                 250                 


<210>  193
<211>  284
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature ICOSLG(B7RP1, CD275, ICOSL, B7-H2)

<400>  193

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr Trp Ser 
225                 230                 235                 240 


Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala Ile Gly 
                245                 250                 255     


Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly Ala Trp 
            260                 265                 270         


Ala Val Ser Pro Glu Thr Glu Leu Thr Gly His Val 
        275                 280                 


<210>  194
<211>  506
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD276(B7-H3)

<400>  194

Leu Glu Val Gln Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr 
1               5                   10                  15      


Asp Ala Thr Leu Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu 
            20                  25                  30          


Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val 
        35                  40                  45              


His Ser Phe Ala Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg 
    50                  55                  60                  


Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg 
65                  70                  75                  80  


Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val 
                85                  90                  95      


Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala 
            100                 105                 110         


Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg 
        115                 120                 125             


Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro 
    130                 135                 140                 


Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly 
145                 150                 155                 160 


Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val 
                165                 170                 175     


His Ser Ile Leu Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys 
            180                 185                 190         


Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr 
        195                 200                 205             


Ile Thr Pro Gln Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro 
    210                 215                 220                 


Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys 
225                 230                 235                 240 


Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile 
                245                 250                 255     


Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly 
            260                 265                 270         


Arg Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp 
        275                 280                 285             


Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val 
    290                 295                 300                 


Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly 
305                 310                 315                 320 


Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser 
                325                 330                 335     


Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr 
            340                 345                 350         


Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp 
        355                 360                 365             


Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln 
    370                 375                 380                 


Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val 
385                 390                 395                 400 


Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val 
                405                 410                 415     


Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met 
            420                 425                 430         


Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys 
        435                 440                 445             


Leu Ile Ala Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile 
    450                 455                 460                 


Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly 
465                 470                 475                 480 


Glu Gly Glu Gly Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp 
                485                 490                 495     


Ser Lys Glu Asp Asp Gly Gln Glu Ile Ala 
            500                 505     


<210>  195
<211>  258
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature VTCN1(B7-H4)

<400>  195

Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
1               5                   10                  15      


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
            20                  25                  30          


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
        35                  40                  45              


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
    50                  55                  60                  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
65                  70                  75                  80  


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
                85                  90                  95      


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
            100                 105                 110         


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
        115                 120                 125             


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
    130                 135                 140                 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
145                 150                 155                 160 


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
                165                 170                 175     


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
            180                 185                 190         


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
        195                 200                 205             


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
    210                 215                 220                 


Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser Leu Cys Val Ser Ser 
225                 230                 235                 240 


Phe Phe Ala Ile Ser Trp Ala Leu Leu Pro Leu Ser Pro Tyr Leu Met 
                245                 250                 255     


Leu Lys 
        


<210>  196
<211>  202
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD28

<400>  196

Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn 
1               5                   10                  15      


Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
            20                  25                  30          


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
        35                  40                  45              


Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr 
    50                  55                  60                  


Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile 
                85                  90                  95      


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
            100                 105                 110         


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
        115                 120                 125             


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
    130                 135                 140                 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
145                 150                 155                 160 


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
                165                 170                 175     


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
            180                 185                 190         


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        195                 200         


<210>  197
<211>  188
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CTLA4

<400>  197

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Phe Leu 
        115                 120                 125             


Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe Tyr Ser Phe 
    130                 135                 140                 


Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro 
145                 150                 155                 160 


Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu Pro Glu Cys 
                165                 170                 175     


Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
            180                 185             


<210>  198
<211>  268
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature PDCD1(PD-1)

<400>  198

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser 
145                 150                 155                 160 


Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala 
                165                 170                 175     


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
            180                 185                 190         


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
        195                 200                 205             


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
    210                 215                 220                 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
225                 230                 235                 240 


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
                245                 250                 255     


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
            260                 265             


<210>  199
<211>  179
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature ICOS

<400>  199

Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile Phe His Asn Gly 
1               5                   10                  15      


Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val Gln Gln Phe Lys 
            20                  25                  30          


Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp Leu Thr Lys Thr 
        35                  40                  45              


Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu Lys Phe Cys His 
    50                  55                  60                  


Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Tyr Asn Leu Asp 
65                  70                  75                  80  


His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser Ile Phe Asp Pro 
                85                  90                  95      


Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu His Ile Tyr Glu 
            100                 105                 110         


Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro Ile Gly Cys Ala 
        115                 120                 125             


Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu 
    130                 135                 140                 


Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
145                 150                 155                 160 


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
                165                 170                 175     


Val Thr Leu 
            


<210>  200
<211>  259
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature BTLA(CD272)

<400>  200

Lys Glu Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His 
1               5                   10                  15      


Ser Ile Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr 
            20                  25                  30          


Cys Ala Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr 
        35                  40                  45              


Cys Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn 
    50                  55                  60                  


Ile Ser Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn 
65                  70                  75                  80  


Gly Ser Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser 
                85                  90                  95      


His Ser Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg 
            100                 105                 110         


Pro Ser Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu 
        115                 120                 125             


Leu Pro Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu 
    130                 135                 140                 


Phe Cys Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp 
145                 150                 155                 160 


Thr Ala Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu 
                165                 170                 175     


Gln Thr Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu 
            180                 185                 190         


Thr Gly Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu 
        195                 200                 205             


Gly Ser Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly 
    210                 215                 220                 


Ile Val Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg 
225                 230                 235                 240 


Leu Ala Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys 
                245                 250                 255     


Val Arg Ser 
            


<210>  201
<211>  433
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD4

<400>  201

Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys 
1               5                   10                  15      


Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn 
            20                  25                  30          


Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro 
        35                  40                  45              


Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln 
    50                  55                  60                  


Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp 
65                  70                  75                  80  


Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu 
                85                  90                  95      


Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln 
            100                 105                 110         


Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val 
        115                 120                 125             


Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu 
    130                 135                 140                 


Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr 
145                 150                 155                 160 


Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val 
                165                 170                 175     


Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu 
            180                 185                 190         


Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr 
        195                 200                 205             


Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys 
    210                 215                 220                 


Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg 
225                 230                 235                 240 


Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His 
                245                 250                 255     


Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu 
            260                 265                 270         


Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn 
        275                 280                 285             


Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu 
    290                 295                 300                 


Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu Lys Leu Glu 
305                 310                 315                 320 


Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val Trp Val Leu 
                325                 330                 335     


Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp Ser Gly Gln 
            340                 345                 350         


Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro 
        355                 360                 365             


Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu 
    370                 375                 380                 


Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg 
385                 390                 395                 400 


Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu 
                405                 410                 415     


Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro 
            420                 425                 430         


Ile 
    


<210>  202
<211>  214
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD8A(CD8-alpha)

<400>  202

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        115                 120                 125             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    130                 135                 140                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
145                 150                 155                 160 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                165                 170                 175     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg 
            180                 185                 190         


Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser 
        195                 200                 205             


Leu Ser Ala Arg Tyr Val 
    210                 


<210>  203
<211>  189
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD8B(CD8-beta)

<400>  203

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu 
145                 150                 155                 160 


Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys Cys Arg Arg 
                165                 170                 175     


Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe Tyr Lys 
            180                 185                 


<210>  204
<211>  497
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature LAG3

<400>  204

Val Pro Val Val Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys 
1               5                   10                  15      


Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly 
            20                  25                  30          


Val Thr Trp Gln His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro 
        35                  40                  45              


Gly His Pro Leu Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp 
    50                  55                  60                  


Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly 
65                  70                  75                  80  


Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu 
                85                  90                  95      


Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg 
            100                 105                 110         


Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg 
        115                 120                 125             


Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr 
    130                 135                 140                 


Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn 
145                 150                 155                 160 


Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg 
                165                 170                 175     


Asn Arg Gly Gln Gly Arg Val Pro Val Arg Glu Ser Pro His His His 
            180                 185                 190         


Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser 
        195                 200                 205             


Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser 
    210                 215                 220                 


Ile Met Tyr Asn Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu 
225                 230                 235                 240 


Thr Val Tyr Ala Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu 
                245                 250                 255     


Pro Ala Gly Val Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro 
            260                 265                 270         


Pro Gly Gly Gly Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe 
        275                 280                 285             


Thr Leu Arg Leu Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr 
    290                 295                 300                 


Cys His Ile His Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu 
305                 310                 315                 320 


Ala Ile Ile Thr Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu 
                325                 330                 335     


Gly Lys Leu Leu Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe 
            340                 345                 350         


Val Trp Ser Ser Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro 
        355                 360                 365             


Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys 
    370                 375                 380                 


Gln Leu Tyr Gln Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr 
385                 390                 395                 400 


Glu Leu Ser Ser Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala 
                405                 410                 415     


Leu Pro Ala Gly His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser 
            420                 425                 430         


Leu Leu Leu Leu Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg 
        435                 440                 445             


Gln Trp Arg Pro Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro 
    450                 455                 460                 


Pro Gln Ala Gln Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro 
465                 470                 475                 480 


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln 
                485                 490                 495     


Leu 
    


<210>  205
<211>  280
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature HAVCR2(TIM-3)

<400>  205

Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp 
            20                  25                  30          


Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg 
        35                  40                  45              


Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn 
    50                  55                  60                  


Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr 
65                  70                  75                  80  


Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile 
                85                  90                  95      


Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys 
            100                 105                 110         


Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro 
        115                 120                 125             


Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu 
    130                 135                 140                 


Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn 
145                 150                 155                 160 


Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala 
                165                 170                 175     


Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly Ile Cys Ala Gly Leu 
            180                 185                 190         


Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe Lys Trp Tyr Ser His 
        195                 200                 205             


Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile Ser Leu Ala Asn Leu 
    210                 215                 220                 


Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu Gly Ile Arg Ser Glu 
225                 230                 235                 240 


Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr Glu Val Glu Glu Pro 
                245                 250                 255     


Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln Gln Pro Ser Gln Pro 
            260                 265                 270         


Leu Gly Cys Arg Phe Ala Met Pro 
        275                 280 


<210>  206
<211>  492
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CEACAM1

<400>  206

Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val Gly Tyr 
        35                  40                  45              


Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Thr 
                165                 170                 175     


Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn Arg Ser 
            180                 185                 190         


Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro Thr Ile 
        195                 200                 205             


Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser Leu Ser 
    210                 215                 220                 


Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser Val Thr 
            260                 265                 270         


Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu Leu Ser 
        275                 280                 285             


Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr Val Thr 
    290                 295                 300                 


Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp Thr Gly 
305                 310                 315                 320 


Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser Ser Glu 
                325                 330                 335     


Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn Pro Val 
            340                 345                 350         


Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn Pro Ile 
        355                 360                 365             


Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr Asn Ala 
    370                 375                 380                 


Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly Ile Val 
385                 390                 395                 400 


Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu Ala Cys 
                405                 410                 415     


Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg Asp Leu 
            420                 425                 430         


Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His Ser Asn 
        435                 440                 445             


Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu Asn Phe 
    450                 455                 460                 


Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser Leu Thr 
465                 470                 475                 480 


Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
                485                 490         


<210>  207
<211>  222
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature TIGIT

<400>  207

Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys Gly 
1               5                   10                  15      


Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln Val 
            20                  25                  30          


Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys Asn 
        35                  40                  45              


Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val Ala 
    50                  55                  60                  


Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn Asp 
65                  70                  75                  80  


Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr Tyr 
                85                  90                  95      


Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu His 
            100                 105                 110         


Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly Ala Met Ala Ala Thr Leu 
        115                 120                 125             


Val Val Ile Cys Thr Ala Val Ile Val Val Val Ala Leu Thr Arg Lys 
    130                 135                 140                 


Lys Lys Ala Leu Arg Ile His Ser Val Glu Gly Asp Leu Arg Arg Lys 
145                 150                 155                 160 


Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser Ala Pro Ser Pro Pro Gly 
                165                 170                 175     


Ser Cys Val Gln Ala Glu Ala Ala Pro Ala Gly Leu Cys Gly Glu Gln 
            180                 185                 190         


Arg Gly Glu Asp Cys Ala Glu Leu His Asp Tyr Phe Asn Val Leu Ser 
        195                 200                 205             


Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe Thr Glu Thr Gly 
    210                 215                 220         


<210>  208
<211>  397
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature PVR(CD155)

<400>  208

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile Leu Val Phe Leu 
                325                 330                 335     


Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser Lys Cys Ser Arg 
            340                 345                 350         


Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser Thr Glu His Ala 
        355                 360                 365             


Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala Val Ser Arg Glu 
    370                 375                 380                 


Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr Arg 
385                 390                 395         


<210>  209
<211>  507
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature PVRL2(CD112)

<400>  209

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala 
                325                 330                 335     


Ala Ile Ile Ala Thr Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg 
            340                 345                 350         


Gln Gln Arg Lys Glu Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp 
        355                 360                 365             


Leu Glu Gly Pro Pro Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu 
    370                 375                 380                 


Glu Ala Gln Glu Met Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu 
385                 390                 395                 400 


His Ser Pro Leu Lys Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr 
                405                 410                 415     


Glu Gln Glu Met Pro Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg 
            420                 425                 430         


Ser Gly Pro Leu His Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro 
        435                 440                 445             


Val Pro Pro Gly Pro Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu 
    450                 455                 460                 


Asp Glu Glu Gly Glu Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro 
465                 470                 475                 480 


Ile Tyr Asp Ala Leu Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly 
                485                 490                 495     


Lys Gly Phe Val Met Ser Arg Ala Met Tyr Val 
            500                 505         


<210>  210
<211>  318
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD226

<400>  210

Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn Met Ser 
1               5                   10                  15      


Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val Glu Trp 
            20                  25                  30          


Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser Pro Thr 
        35                  40                  45              


His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr Phe Leu 
    50                  55                  60                  


Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg Asn Ala 
65                  70                  75                  80  


Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr Tyr Pro 
                85                  90                  95      


Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp Ser Phe 
            100                 105                 110         


Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro Gly Lys 
        115                 120                 125             


Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val Gln Ala 
    130                 135                 140                 


Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu Thr Tyr 
145                 150                 155                 160 


Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro Arg Gln 
                165                 170                 175     


Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val Ile Pro 
            180                 185                 190         


Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu Gln Ala 
        195                 200                 205             


Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val Ala Glu 
    210                 215                 220                 


Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly Thr Val 
225                 230                 235                 240 


Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val Ile Phe 
                245                 250                 255     


Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr Glu Ser 
            260                 265                 270         


Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile Ser Thr 
        275                 280                 285             


Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp Ile Tyr 
    290                 295                 300                 


Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
305                 310                 315             


<210>  211
<211>  327
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD2

<400>  211

Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly Ala Leu Gly Gln Asp 
1               5                   10                  15      


Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser Asp Asp Ile Asp Asp 
            20                  25                  30          


Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys Ile Ala Gln Phe Arg 
        35                  40                  45              


Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr Tyr Lys Leu Phe Lys 
    50                  55                  60                  


Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr Asp Asp Gln Asp Ile 
65                  70                  75                  80  


Tyr Lys Val Ser Ile Tyr Asp Thr Lys Gly Lys Asn Val Leu Glu Lys 
                85                  90                  95      


Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser 
            100                 105                 110         


Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu Val Met Asn Gly Thr 
        115                 120                 125             


Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys His Leu Lys Leu Ser 
    130                 135                 140                 


Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser Leu Ser Ala Lys Phe 
145                 150                 155                 160 


Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu Ser Ser Val Glu Pro 
                165                 170                 175     


Val Ser Cys Pro Glu Lys Gly Leu Asp Ile Tyr Leu Ile Ile Gly Ile 
            180                 185                 190         


Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val Ala Leu Leu Val Phe 
        195                 200                 205             


Tyr Ile Thr Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu 
    210                 215                 220                 


Leu Glu Thr Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys 
225                 230                 235                 240 


Pro His Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln 
                245                 250                 255     


His Pro Pro Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg 
            260                 265                 270         


Pro Pro Pro Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro 
        275                 280                 285             


Pro Ala Pro Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu 
    290                 295                 300                 


Pro Arg Pro Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn 
305                 310                 315                 320 


Ser Leu Ser Pro Ser Ser Asn 
                325         


<210>  212
<211>  154
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD160

<400>  212

Ile Asn Ile Thr Ser Ser Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu 
1               5                   10                  15      


Ile Cys Thr Val Trp His Lys Lys Glu Glu Ala Glu Gly Phe Val Val 
            20                  25                  30          


Phe Leu Cys Lys Asp Arg Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu 
        35                  40                  45              


Lys Gln Leu Arg Leu Lys Arg Asp Pro Gly Ile Asp Gly Val Gly Glu 
    50                  55                  60                  


Ile Ser Ser Gln Leu Met Phe Thr Ile Ser Gln Val Thr Pro Leu His 
65                  70                  75                  80  


Ser Gly Thr Tyr Gln Cys Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg 
                85                  90                  95      


Leu Gln Gly His Phe Phe Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr 
            100                 105                 110         


Thr Val Thr Gly Leu Lys Gln Arg Gln His Leu Glu Phe Ser His Asn 
        115                 120                 125             


Glu Gly Thr Leu Ser Ser Gly Phe Leu Gln Glu Lys Val Trp Val Met 
    130                 135                 140                 


Leu Val Thr Ser Leu Val Ala Leu Gln Ala 
145                 150                 


<210>  213
<211>  248
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD200

<400>  213

Gln Val Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro 
1               5                   10                  15      


Ala Ser Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val 
            20                  25                  30          


Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe 
        35                  40                  45              


Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile 
    50                  55                  60                  


Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn 
65                  70                  75                  80  


Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe 
                85                  90                  95      


Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln 
            100                 105                 110         


Pro Ile Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile 
        115                 120                 125             


Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val 
    130                 135                 140                 


Pro Arg Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn 
145                 150                 155                 160 


Gly Thr Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn 
                165                 170                 175     


Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val 
            180                 185                 190         


Thr Asp Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro 
        195                 200                 205             


Leu Leu Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser 
    210                 215                 220                 


Ile Leu Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Gly Glu Leu 
225                 230                 235                 240 


Ser Gln Gly Val Gln Lys Met Thr 
                245             


<210>  214
<211>  297
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD200R1(CD200R)

<400>  214

Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu 
1               5                   10                  15      


Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys 
            20                  25                  30          


Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile 
        35                  40                  45              


Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr 
    50                  55                  60                  


Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val 
65                  70                  75                  80  


Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile 
                85                  90                  95      


Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn 
            100                 105                 110         


Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr 
        115                 120                 125             


Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly 
    130                 135                 140                 


Lys Pro Ala Ala Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr 
145                 150                 155                 160 


Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys 
                165                 170                 175     


His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His Val Ser His 
            180                 185                 190         


Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly 
        195                 200                 205             


Ala Lys Lys Ser Ala Lys Leu Tyr Ile Pro Tyr Ile Ile Leu Thr Ile 
    210                 215                 220                 


Ile Ile Leu Thr Ile Val Gly Phe Ile Trp Leu Leu Lys Val Asn Gly 
225                 230                 235                 240 


Cys Arg Lys Tyr Lys Leu Asn Lys Thr Glu Ser Thr Pro Val Val Glu 
                245                 250                 255     


Glu Asp Glu Met Gln Pro Tyr Ala Ser Tyr Thr Glu Lys Asn Asn Pro 
            260                 265                 270         


Leu Tyr Asp Thr Thr Asn Lys Val Lys Ala Ser Glu Ala Leu Gln Ser 
        275                 280                 285             


Glu Val Asp Thr Asp Leu His Thr Leu 
    290                 295         


<210>  215
<211>  183
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature NC R3 (NKp30)

<400>  215

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         


His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala Gly Phe 
        115                 120                 125             


Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val Tyr Tyr 
    130                 135                 140                 


Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg Gln Leu Pro Ala 
145                 150                 155                 160 


Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser Ser Ala His Leu 
                165                 170                 175     


Leu Pro Pro Val Pro Gly Gly 
            180             


<210>  216
<211>  414
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  VSIG8

<400>  216

Met Arg Val Gly Gly Ala Phe His Leu Leu Leu Val Cys Leu Ser Pro 
1               5                   10                  15      


Ala Leu Leu Ser Ala Val Arg Ile Asn Gly Asp Gly Gln Glu Val Leu 
            20                  25                  30          


Tyr Leu Ala Glu Gly Asp Asn Val Arg Leu Gly Cys Pro Tyr Val Leu 
        35                  40                  45              


Asp Pro Glu Asp Tyr Gly Pro Asn Gly Leu Asp Ile Glu Trp Met Gln 
    50                  55                  60                  


Val Asn Ser Asp Pro Ala His His Arg Glu Asn Val Phe Leu Ser Tyr 
65                  70                  75                  80  


Gln Asp Lys Arg Ile Asn His Gly Ser Leu Pro His Leu Gln Gln Arg 
                85                  90                  95      


Val Arg Phe Ala Ala Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn 
            100                 105                 110         


Leu Met Asn Leu Gln Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val 
        115                 120                 125             


Lys Lys Thr Thr Met Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala 
    130                 135                 140                 


Arg Pro Ala Val Pro Met Cys Trp Thr Glu Gly His Met Thr Tyr Gly 
145                 150                 155                 160 


Asn Asp Val Val Leu Lys Cys Tyr Ala Ser Gly Gly Ser Gln Pro Leu 
                165                 170                 175     


Ser Tyr Lys Trp Ala Lys Ile Ser Gly His His Tyr Pro Tyr Arg Ala 
            180                 185                 190         


Gly Ser Tyr Thr Ser Gln His Ser Tyr His Ser Glu Leu Ser Tyr Gln 
        195                 200                 205             


Glu Ser Phe His Ser Ser Ile Asn Gln Gly Leu Asn Asn Gly Asp Leu 
    210                 215                 220                 


Val Leu Lys Asp Ile Ser Arg Ala Asp Asp Gly Leu Tyr Gln Cys Thr 
225                 230                 235                 240 


Val Ala Asn Asn Val Gly Tyr Ser Val Cys Val Val Glu Val Lys Val 
                245                 250                 255     


Ser Asp Ser Arg Arg Ile Gly Val Ile Ile Gly Ile Val Leu Gly Ser 
            260                 265                 270         


Leu Leu Ala Leu Gly Cys Leu Ala Val Gly Ile Trp Gly Leu Val Cys 
        275                 280                 285             


Cys Cys Cys Gly Gly Ser Gly Ala Gly Gly Ala Arg Gly Ala Phe Gly 
    290                 295                 300                 


Tyr Gly Asn Gly Gly Gly Val Gly Gly Gly Ala Cys Gly Asp Leu Ala 
305                 310                 315                 320 


Ser Glu Ile Arg Glu Asp Ala Val Ala Pro Gly Cys Lys Ala Ser Gly 
                325                 330                 335     


Arg Gly Ser Arg Val Thr His Leu Leu Gly Tyr Pro Thr Gln Asn Val 
            340                 345                 350         


Ser Arg Ser Leu Arg Arg Lys Tyr Ala Pro Pro Pro Cys Gly Gly Pro 
        355                 360                 365             


Glu Asp Val Ala Leu Ala Pro Cys Thr Ala Ala Ala Ala Cys Glu Ala 
    370                 375                 380                 


Gly Pro Ser Pro Val Tyr Val Lys Val Lys Ser Ala Glu Pro Ala Asp 
385                 390                 395                 400 


Cys Ala Glu Gly Pro Val Gln Cys Lys Asn Gly Leu Leu Val 
                405                 410                 


<210>  217
<211>  393
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature VSIG8

<400>  217

Val Arg Ile Asn Gly Asp Gly Gln Glu Val Leu Tyr Leu Ala Glu Gly 
1               5                   10                  15      


Asp Asn Val Arg Leu Gly Cys Pro Tyr Val Leu Asp Pro Glu Asp Tyr 
            20                  25                  30          


Gly Pro Asn Gly Leu Asp Ile Glu Trp Met Gln Val Asn Ser Asp Pro 
        35                  40                  45              


Ala His His Arg Glu Asn Val Phe Leu Ser Tyr Gln Asp Lys Arg Ile 
    50                  55                  60                  


Asn His Gly Ser Leu Pro His Leu Gln Gln Arg Val Arg Phe Ala Ala 
65                  70                  75                  80  


Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn Leu Met Asn Leu Gln 
                85                  90                  95      


Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val Lys Lys Thr Thr Met 
            100                 105                 110         


Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala Arg Pro Ala Val Pro 
        115                 120                 125             


Met Cys Trp Thr Glu Gly His Met Thr Tyr Gly Asn Asp Val Val Leu 
    130                 135                 140                 


Lys Cys Tyr Ala Ser Gly Gly Ser Gln Pro Leu Ser Tyr Lys Trp Ala 
145                 150                 155                 160 


Lys Ile Ser Gly His His Tyr Pro Tyr Arg Ala Gly Ser Tyr Thr Ser 
                165                 170                 175     


Gln His Ser Tyr His Ser Glu Leu Ser Tyr Gln Glu Ser Phe His Ser 
            180                 185                 190         


Ser Ile Asn Gln Gly Leu Asn Asn Gly Asp Leu Val Leu Lys Asp Ile 
        195                 200                 205             


Ser Arg Ala Asp Asp Gly Leu Tyr Gln Cys Thr Val Ala Asn Asn Val 
    210                 215                 220                 


Gly Tyr Ser Val Cys Val Val Glu Val Lys Val Ser Asp Ser Arg Arg 
225                 230                 235                 240 


Ile Gly Val Ile Ile Gly Ile Val Leu Gly Ser Leu Leu Ala Leu Gly 
                245                 250                 255     


Cys Leu Ala Val Gly Ile Trp Gly Leu Val Cys Cys Cys Cys Gly Gly 
            260                 265                 270         


Ser Gly Ala Gly Gly Ala Arg Gly Ala Phe Gly Tyr Gly Asn Gly Gly 
        275                 280                 285             


Gly Val Gly Gly Gly Ala Cys Gly Asp Leu Ala Ser Glu Ile Arg Glu 
    290                 295                 300                 


Asp Ala Val Ala Pro Gly Cys Lys Ala Ser Gly Arg Gly Ser Arg Val 
305                 310                 315                 320 


Thr His Leu Leu Gly Tyr Pro Thr Gln Asn Val Ser Arg Ser Leu Arg 
                325                 330                 335     


Arg Lys Tyr Ala Pro Pro Pro Cys Gly Gly Pro Glu Asp Val Ala Leu 
            340                 345                 350         


Ala Pro Cys Thr Ala Ala Ala Ala Cys Glu Ala Gly Pro Ser Pro Val 
        355                 360                 365             


Tyr Val Lys Val Lys Ser Ala Glu Pro Ala Asp Cys Ala Glu Gly Pro 
    370                 375                 380                 


Val Gln Cys Lys Asn Gly Leu Leu Val 
385                 390             


<210>  218
<211>  242
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  VSIG8 ECD

<400>  218

Val Arg Ile Asn Gly Asp Gly Gln Glu Val Leu Tyr Leu Ala Glu Gly 
1               5                   10                  15      


Asp Asn Val Arg Leu Gly Cys Pro Tyr Val Leu Asp Pro Glu Asp Tyr 
            20                  25                  30          


Gly Pro Asn Gly Leu Asp Ile Glu Trp Met Gln Val Asn Ser Asp Pro 
        35                  40                  45              


Ala His His Arg Glu Asn Val Phe Leu Ser Tyr Gln Asp Lys Arg Ile 
    50                  55                  60                  


Asn His Gly Ser Leu Pro His Leu Gln Gln Arg Val Arg Phe Ala Ala 
65                  70                  75                  80  


Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn Leu Met Asn Leu Gln 
                85                  90                  95      


Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val Lys Lys Thr Thr Met 
            100                 105                 110         


Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala Arg Pro Ala Val Pro 
        115                 120                 125             


Met Cys Trp Thr Glu Gly His Met Thr Tyr Gly Asn Asp Val Val Leu 
    130                 135                 140                 


Lys Cys Tyr Ala Ser Gly Gly Ser Gln Pro Leu Ser Tyr Lys Trp Ala 
145                 150                 155                 160 


Lys Ile Ser Gly His His Tyr Pro Tyr Arg Ala Gly Ser Tyr Thr Ser 
                165                 170                 175     


Gln His Ser Tyr His Ser Glu Leu Ser Tyr Gln Glu Ser Phe His Ser 
            180                 185                 190         


Ser Ile Asn Gln Gly Leu Asn Asn Gly Asp Leu Val Leu Lys Asp Ile 
        195                 200                 205             


Ser Arg Ala Asp Asp Gly Leu Tyr Gln Cys Thr Val Ala Asn Asn Val 
    210                 215                 220                 


Gly Tyr Ser Val Cys Val Val Glu Val Lys Val Ser Asp Ser Arg Arg 
225                 230                 235                 240 


Ile Gly 
        


<210>  219
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 Signal Peptide

<400>  219

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210>  220
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgGkappa light chain

<400>  220

Met Asp Met Arg Val Leu Ala Gln Leu Leu Gly Leu Leu Leu Leu Cys 
1               5                   10                  15      


Phe Pro Gly Ala Arg Cys 
            20          


<210>  221
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA signal peptide

<400>  221

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  222
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ig kappa light chain

<400>  222

Met Asp Met Arg Ala Pro Ala Gly Ile Phe Gly Phe Leu Leu Val Leu 
1               5                   10                  15      


Phe Pro Gly Tyr Arg Ser 
            20          


<210>  223
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human azurocidin preprotein signal sequence

<400>  223

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala 
            


<210>  224
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  224

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  225
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  225

Met Glu Leu Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  226
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  226

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser 
            


<210>  227
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  227

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  228
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  228

Met Asp Trp Thr Trp Arg Phe Leu Phe Val Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Val Gln Ser 
            


<210>  229
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  229

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  230
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  230

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  231
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  231

Met Asp Leu Leu His Lys Asn Met Lys His Leu Trp Phe Phe Leu Leu 
1               5                   10                  15      


Leu Val Ala Ala Pro Arg Trp Val Leu Ser 
            20                  25      


<210>  232
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG Kappa light chain signal seqeunce

<400>  232

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys 
            20          


<210>  233
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG Kappa light chain signal seqeunce

<400>  233

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210>  234
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gaussia luciferase

<400>  234

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala 
    


<210>  235
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human albumin

<400>  235

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  236
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human chymotrypsinogen

<400>  236

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  237
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human interleukin-2

<400>  237

Met Gln Leu Leu Ser Cys Ile Ala Leu Ile Leu Ala Leu Val 
1               5                   10                  


<210>  238
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human trysinogen-2

<400>  238

Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala 
1               5                   10                  15  


<210>  239
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  239

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  240
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  240

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  241
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  241

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala 
1               5                   10              


<210>  242
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-derived hinge and transmembrane domain

<400>  242

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile 
        35                  40                  45              


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    50                  55                  60                  


Leu Val Ile Thr Leu Tyr Cys 
65                  70      


<210>  243
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zeta intracellular signaling domain

<400>  243

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  244
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v1

<400>  244

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Asn Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val Asn Gly Glu Glu Asp Leu Glu Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  245
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v2

<400>  245

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Thr Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  246
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v3

<400>  246

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Glu Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  247
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v4

<400>  247

Phe Thr Val Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Thr Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  248
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v5

<400>  248

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  249
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v6

<400>  249

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  250
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v7

<400>  250

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  251
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v8

<400>  251

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  252
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v9

<400>  252

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  253
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v10

<400>  253

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  254
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v11

<400>  254

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  255
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v12

<400>  255

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asp Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Gly Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  256
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v13

<400>  256

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Ser Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  257
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v14

<400>  257

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  258
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v15

<400>  258

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  259
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v16

<400>  259

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  260
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v17

<400>  260

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  261
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v18

<400>  261

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  262
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v19

<400>  262

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Glu Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  263
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v20

<400>  263

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Ile Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val Arg Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  264
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v21

<400>  264

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Glu Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln Arg Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  265
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v22

<400>  265

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  266
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v23

<400>  266

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Gly 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Glu Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  267
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v24

<400>  267

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  268
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v25

<400>  268

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  269
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v26

<400>  269

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Val Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  270
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v27

<400>  270

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  271
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v28

<400>  271

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Gly Met Glu Val Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  272
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v29

<400>  272

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Ser Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  273
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v30

<400>  273

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  274
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v31

<400>  274

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  275
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v32

<400>  275

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  276
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v33

<400>  276

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  277
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v34

<400>  277

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  278
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v35

<400>  278

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  279
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v36

<400>  279

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Met Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  280
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v37

<400>  280

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  281
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v38

<400>  281

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Pro Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  282
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v39

<400>  282

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  283
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v40

<400>  283

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Arg Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  284
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v41

<400>  284

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  285
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v42

<400>  285

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Val Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  286
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v43

<400>  286

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Gly Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  287
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v44

<400>  287

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  288
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v45

<400>  288

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  289
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v46

<400>  289

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  290
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v47

<400>  290

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  291
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v48

<400>  291

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  292
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v49

<400>  292

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  293
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v50

<400>  293

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  294
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v51

<400>  294

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  295
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v52

<400>  295

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Ala Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val Tyr Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  296
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v53

<400>  296

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  297
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v54

<400>  297

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  298
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v55

<400>  298

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  299
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v56

<400>  299

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Gly Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  300
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v57

<400>  300

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  301
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v58

<400>  301

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  302
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v59

<400>  302

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Gly Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Asp Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  303
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v60

<400>  303

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala 
        115 


<210>  304
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v61

<400>  304

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  305
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v62

<400>  305

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  306
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v63

<400>  306

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Ile Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Ile Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Lys Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  307
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v64

<400>  307

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  308
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v65

<400>  308

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  309
<211>  114
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PD-L1 IgV wildtype

<400>  309

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  310
<211>  116
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD155 IgV

<400>  310

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  311
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v1 ECD

<400>  311

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Ser 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  312
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v2 ECD

<400>  312

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Pro Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  313
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v3 ECD

<400>  313

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Pro Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  314
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v4 ECD

<400>  314

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Val Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  315
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v5 ECD

<400>  315

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Val Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  316
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v6 ECD

<400>  316

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  317
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v7 ECD

<400>  317

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  318
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v8 ECD

<400>  318

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Pro Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  319
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v9 ECD

<400>  319

Trp Pro Pro Pro Gly Thr Glu Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Cys Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  320
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v10 ECD

<400>  320

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Asp Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  321
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v11 ECD

<400>  321

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Pro Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  322
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v12 ECD

<400>  322

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Leu Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  323
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v14 ECD

<400>  323

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  324
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v15 ECD

<400>  324

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu His Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  325
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v16 ECD

<400>  325

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Cys Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  326
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v17 ECD

<400>  326

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Val Glu Pro Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  327
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v18 ECD

<400>  327

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Pro Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  328
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v19 ECD

<400>  328

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu His Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  329
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v20 ECD

<400>  329

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Glu Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Val Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  330
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v21 ECD

<400>  330

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Ala Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  331
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v22 ECD

<400>  331

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Lys Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  332
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v1 IgV

<400>  332

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Ser Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  333
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v2 IgV

<400>  333

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Pro Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  334
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v3 IgV

<400>  334

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Pro Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  335
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v4 IgV

<400>  335

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Val Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  336
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v5 IgV

<400>  336

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Val Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  337
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v6 IgV

<400>  337

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  338
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v7 IgV

<400>  338

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  339
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v8 IgV

<400>  339

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Pro Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  340
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v9 IgV

<400>  340

Pro Gly Thr Glu Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Cys Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  341
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v10 IgV

<400>  341

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Asp Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  342
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v11 IgV

<400>  342

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Pro Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  343
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v12 IgV

<400>  343

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Leu Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  344
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v14 IgV

<400>  344

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  345
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v15 IgV

<400>  345

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu His Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  346
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v16 IgV

<400>  346

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Cys Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  347
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v17 IgV

<400>  347

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Val Glu Pro 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  348
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v18 IgV

<400>  348

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Pro Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  349
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v19 IgV

<400>  349

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu His Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  350
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v20 IgV

<400>  350

Pro Gly Thr Gly Asp Val Val Val Gln Glu Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Val Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  351
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v21 IgV

<400>  351

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Ala 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  352
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v22 IgV

<400>  352

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Lys Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  353
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD155 IgV wildtype

<400>  353

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  354
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v1 IgV

<400>  354

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Ser 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  355
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v2 IgV

<400>  355

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Pro Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  356
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v3 IgV

<400>  356

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Pro Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  357
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v4 IgV

<400>  357

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Val Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  358
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v5 IgV

<400>  358

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Val Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  359
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v6 IgV

<400>  359

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  360
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v7 IgV

<400>  360

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  361
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v8 IgV

<400>  361

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Pro Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  362
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v9 IgV

<400>  362

Trp Pro Pro Pro Gly Thr Glu Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Cys Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  363
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v10 IgV

<400>  363

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Asp Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  364
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v11 IgV

<400>  364

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Pro Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  365
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v12 IgV

<400>  365

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Leu Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  366
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v14 IgV

<400>  366

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  367
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v15 IgV

<400>  367

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu His Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  368
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v16 IgV

<400>  368

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Cys Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  369
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v17 IgV

<400>  369

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Val Glu Pro Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  370
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v18 IgV

<400>  370

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Pro Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  371
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v19 IgV

<400>  371

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu His Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  372
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v20 IgV

<400>  372

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Glu Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Val Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  373
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v21 IgV

<400>  373

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Ala Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  374
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v22 IgV

<400>  374

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Lys Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  375
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v23 ECD

<400>  375

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  376
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v24 ECD

<400>  376

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  377
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v25 ECD

<400>  377

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  378
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v26 ECD

<400>  378

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  379
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v27 ECD

<400>  379

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  380
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v28 ECD

<400>  380

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  381
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v39 ECD

<400>  381

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  382
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v30 ECD

<400>  382

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Trp Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  383
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v31 ECD

<400>  383

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  384
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v32 ECD

<400>  384

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Trp Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  385
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v33 ECD

<400>  385

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  386
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v34 ECD

<400>  386

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  387
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v35 ECD

<400>  387

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  388
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v36 ECD

<400>  388

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Gln Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  389
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v37 ECD

<400>  389

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  390
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v38 ECD

<400>  390

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  391
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v39 ECD

<400>  391

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  392
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v40 ECD

<400>  392

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  393
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v41 ECD

<400>  393

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  394
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v42 ECD

<400>  394

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  395
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v43 ECD

<400>  395

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  396
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v44 ECD

<400>  396

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  397
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v45 ECD

<400>  397

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Met Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  398
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v46 ECD

<400>  398

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  399
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v47 ECD

<400>  399

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  400
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v48 ECD

<400>  400

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Leu Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  401
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v49 ECD

<400>  401

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  402
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v50 ECD

<400>  402

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  403
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v51 ECD

<400>  403

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  404
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v52 ECD

<400>  404

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  405
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v53 ECD

<400>  405

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  406
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v54 ECD

<400>  406

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  407
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v55 ECD

<400>  407

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  408
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v56 ECD

<400>  408

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  409
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v57 ECD

<400>  409

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  410
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v58 ECD

<400>  410

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  411
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v59 ECD

<400>  411

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  412
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v60 ECD

<400>  412

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Val Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  413
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v61 ECD

<400>  413

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  414
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v62 ECD

<400>  414

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  415
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v63 ECD

<400>  415

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Glu Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  416
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v64 ECD

<400>  416

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  417
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v65 ECD

<400>  417

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  418
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v66 ECD

<400>  418

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  419
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v67 ECD

<400>  419

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  420
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v68 ECD

<400>  420

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  421
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v69 ECD

<400>  421

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  422
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v70 ECD

<400>  422

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Ala His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro 
    50                  55                  60                  


Asn Tyr Leu Glu Ser Lys Arg Leu Gly Phe Val Ala Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  423
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v71 ECD

<400>  423

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro 
    50                  55                  60                  


Asn Tyr Leu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  424
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v72 ECD

<400>  424

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  425
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v73 ECD

<400>  425

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro 
    50                  55                  60                  


Asn Tyr Leu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Pro Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  426
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v74 ECD

<400>  426

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  427
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v75 ECD

<400>  427

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  428
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v76 ECD

<400>  428

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  429
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v77 ECD

<400>  429

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  430
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v78 ECD

<400>  430

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro 
    50                  55                  60                  


His Tyr His Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  431
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v79 ECD

<400>  431

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  432
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v80 ECD

<400>  432

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gly Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser 
65                  70                  75                  80  


Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  433
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v81 ECD

<400>  433

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Pro Val Thr His Val Pro Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  434
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v82 ECD

<400>  434

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  435
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v83 ECD

<400>  435

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Val Arg Leu Ser 
65                  70                  75                  80  


Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  436
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v84 ECD

<400>  436

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Ser Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser 
65                  70                  75                  80  


Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  437
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v85 ECD

<400>  437

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  438
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v86 ECD

<400>  438

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr His Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  439
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v87 ECD

<400>  439

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Lys Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  440
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v88 ECD

<400>  440

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  441
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v89 ECD

<400>  441

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  442
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v90 ECD

<400>  442

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Ala Phe His Gln Met Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Asp 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  443
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v91 ECD

<400>  443

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Thr Phe His Gln Ser Gln Gly Pro 
    50                  55                  60                  


Tyr Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  444
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v92 ECD

<400>  444

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  445
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v94 ECD

<400>  445

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Ala Phe His Gln Met Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  446
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v94 ECD

<400>  446

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Met Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  447
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v94 ECD

<400>  447

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Ala Gly Gln Leu Gly Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  448
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v96 ECD

<400>  448

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val His Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Ile Trp Ala Arg 
        35                  40                  45              


His Gly Glu Thr Arg His Met Ala Leu Phe Glu Gln Ser Gln Gly Pro 
    50                  55                  60                  


Asp Tyr Ser Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  449
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v97 ECD

<400>  449

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Val Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Leu His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Trp Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  450
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v98 ECD

<400>  450

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ile Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  451
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v99 ECD

<400>  451

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Gly Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Asn Phe Ala Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  452
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v100 ECD

<400>  452

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val His Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr Arg Val Gly Gln Leu Ile Trp Ala Arg 
        35                  40                  45              


His Gly Glu Thr Arg His Met Ala Leu Phe Glu Gln Ser Gln Gly Pro 
    50                  55                  60                  


Asp Tyr Ser Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Tyr Phe Leu Thr His Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  453
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v101 ECD

<400>  453

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Val Val Thr His Val Gly Gln Leu Gly Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  454
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v102 ECD

<400>  454

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  455
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v103 ECD

<400>  455

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  456
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v104 ECD

<400>  456

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Pro Val Thr His Val Leu Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gly Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  457
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v105 ECD

<400>  457

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asn Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  458
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v106 ECD

<400>  458

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser 
65                  70                  75                  80  


Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  459
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v107 ECD

<400>  459

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Thr Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  460
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v108 ECD

<400>  460

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gly Gly Ser Met Ala Ala Phe His Gln Thr Met Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  461
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v109 ECD

<400>  461

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Val Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Asp Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  462
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v110 ECD

<400>  462

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro 
    50                  55                  60                  


Thr Tyr Ser Glu Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Gly Ser Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asn Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  463
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v111 ECD

<400>  463

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Pro Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Gly Gln Gly Pro 
    50                  55                  60                  


His Tyr Glu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asn Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  464
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v112 ECD

<400>  464

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro 
    50                  55                  60                  


Thr Tyr Ser Glu Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Ala Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  465
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v113 ECD

<400>  465

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro 
    50                  55                  60                  


Thr Tyr Ser Gly Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Gly Ser Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  466
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v114 ECD

<400>  466

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  467
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v115 ECD

<400>  467

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  468
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v116 ECD

<400>  468

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Asp Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  469
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v117 ECD

<400>  469

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ser Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Lys Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  470
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v118 ECD

<400>  470

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  471
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v119 ECD

<400>  471

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Val Phe Gly Leu Arg Ala Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  472
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v23 IgV

<400>  472

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  473
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v24 IgV

<400>  473

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  474
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v25 IgV

<400>  474

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  475
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v26 IgV

<400>  475

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  476
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v27 IgV

<400>  476

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu Arg Val Leu 
        115                 


<210>  477
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v28 IgV

<400>  477

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  478
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v29 IgV

<400>  478

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  479
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v30 IgV

<400>  479

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Trp Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  480
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v31 IgV

<400>  480

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  481
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v32 IgV

<400>  481

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Trp Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  482
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v33 IgV

<400>  482

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  483
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v34 IgV

<400>  483

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Leu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  484
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v35 IgV

<400>  484

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  485
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v36 IgV

<400>  485

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Gln Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  486
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v37 IgV

<400>  486

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  487
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v38 IgV

<400>  487

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  488
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v39 IgV

<400>  488

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  489
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v40 IgV

<400>  489

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  490
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v41 IgV

<400>  490

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  491
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v42 IgV

<400>  491

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  492
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v43 IgV

<400>  492

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  493
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v44 IgV

<400>  493

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  494
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v45 IgV

<400>  494

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Met Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  495
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v46 IgV

<400>  495

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Gln Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  496
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v47 IgV

<400>  496

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  497
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v48 IgV

<400>  497

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Gln Gly Ser Met Ala Leu Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  498
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v49 IgV

<400>  498

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  499
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v50 IgV

<400>  499

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  500
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v51 IgV

<400>  500

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  501
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v52 IgV

<400>  501

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Arg Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  502
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v53 IgV

<400>  502

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  503
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v54 IgV

<400>  503

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Arg Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  504
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v55 IgV

<400>  504

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Leu Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  505
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v56 IgV

<400>  505

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Met Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  506
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v57 IgV

<400>  506

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  507
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v58 IgV

<400>  507

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  508
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v59 IgV

<400>  508

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  509
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v60 IgV

<400>  509

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Val Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  510
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v61 IgV

<400>  510

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  511
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v62 IgV

<400>  511

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  512
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v63 IgV

<400>  512

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Glu Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  513
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v64 IgV

<400>  513

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Met Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  514
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v65 IgV

<400>  514

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  515
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v66 IgV

<400>  515

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  516
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v67 IgV

<400>  516

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Leu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  517
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v68 IgV

<400>  517

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  518
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v69 IgV

<400>  518

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  519
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v70 IgV

<400>  519

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Ala His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro Asn Tyr Leu 
    50                  55                  60                  


Glu Ser Lys Arg Leu Gly Phe Val Ala Ala Gly Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  520
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v71 IgV

<400>  520

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro Asn Tyr Leu 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  521
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v72 IgV

<400>  521

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  522
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v73 IgV

<400>  522

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro Asn Tyr Leu 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Pro Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  523
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v74 IgV

<400>  523

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  524
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v75 IgV

<400>  524

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  525
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v76 IgV

<400>  525

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  526
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v77 IgV

<400>  526

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  527
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v78 IgV

<400>  527

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro His Tyr His 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  528
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v79 IgV

<400>  528

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Glu Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  529
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v80 IgV

<400>  529

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Gly Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser Pro Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Tyr 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  530
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v81 IgV

<400>  530

Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Pro Val Thr His Val Pro Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Glu Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  531
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v82 IgV

<400>  531

Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Tyr 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  532
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v83 IgV

<400>  532

Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Val Arg Leu Ser Pro Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Tyr 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  533
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v84 IgV

<400>  533

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Ser Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser Pro Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Tyr 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  534
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v85 IgV

<400>  534

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  535
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v86 IgV

<400>  535

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr His Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  536
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v87 IgV

<400>  536

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Lys Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  537
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v88 IgV

<400>  537

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Gln Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  538
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v89 IgV

<400>  538

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Gln Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  539
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v90 IgV

<400>  539

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Ala Phe His Gln Met Gln Gly Pro Trp Tyr Ala 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Asp Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  540
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v91 IgV

<400>  540

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Thr Phe His Gln Ser Gln Gly Pro Tyr Tyr Ala 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  541
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v92 IgV

<400>  541

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  542
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v93 IgV

<400>  542

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Ala Phe His Gln Met Gln Gly Pro Trp Tyr Ala 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  543
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v94 IgV

<400>  543

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Met Gln Gly Pro Trp Tyr Ala 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  544
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v95 IgV

<400>  544

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Ala Gly Gln Leu Gly Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  545
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v96 IgV

<400>  545

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val His Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Gly Gln Leu Ile Trp Ala Arg His Gly Glu 
        35                  40                  45              


Thr Arg His Met Ala Leu Phe Glu Gln Ser Gln Gly Pro Asp Tyr Ser 
    50                  55                  60                  


Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  546
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v97 IgV

<400>  546

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Gly Gln Leu Val Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Leu His Gln Thr Gln Gly Pro Ser Tyr Trp 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  547
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v98 IgV

<400>  547

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Ile Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  548
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v99 IgV

<400>  548

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Gly Gln Leu Gly Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Asn Phe Ala Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  549
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v100 IgV

<400>  549

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val His Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr Arg Val Gly Gln Leu Ile Trp Ala Arg His Gly Glu 
        35                  40                  45              


Thr Arg His Met Ala Leu Phe Glu Gln Ser Gln Gly Pro Asp Tyr Ser 
    50                  55                  60                  


Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Tyr Phe Leu Thr His Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  550
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v101 IgV

<400>  550

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Val Val Thr His Val Gly Gln Leu Gly Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  551
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v102 IgV

<400>  551

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  552
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v103 IgV

<400>  552

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  553
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v104 IgV

<400>  553

Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Pro Val Thr His Val Leu Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Gly Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Glu Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  554
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v105 IgV

<400>  554

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg Arg Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asn Ile Trp Leu 
        115     


<210>  555
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v106 IgV

<400>  555

Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser Pro Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  556
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v107 IgV

<400>  556

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Thr Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  557
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v108 IgV

<400>  557

Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Gly Gly Ser Met Ala Ala Phe His Gln Thr Met Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  558
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v109 IgV

<400>  558

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Val Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Asp Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  559
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v110 IgV

<400>  559

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg His Gly Glu 
        35                  40                  45              


Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro Thr Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Gly Ser Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asn Ile Trp Leu 
        115     


<210>  560
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v111 IgV

<400>  560

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Pro Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Gly Gln Gly Pro His Tyr Glu 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asn Ile Trp Leu 
        115     


<210>  561
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v112 IgV

<400>  561

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg His Gly Glu 
        35                  40                  45              


Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro Thr Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Ala Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  562
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v113 IgV

<400>  562

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg His Gly Glu 
        35                  40                  45              


Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro Thr Tyr Ser 
    50                  55                  60                  


Gly Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Gly Ser Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  563
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v114 IgV

<400>  563

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  564
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v115 IgV

<400>  564

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu 
        35                  40                  45              


Glu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  565
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v116 IgV

<400>  565

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Asp Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  566
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v117 IgV

<400>  566

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Ser Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Lys Gln Gly Pro Trp Tyr Ala 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  567
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v118 IgV

<400>  567

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  568
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v119 IgV

<400>  568

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Trp Tyr Ala 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Val Phe Gly Leu Arg Ala Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  569
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v23 IgV

<400>  569

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  570
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v24 IgV

<400>  570

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  571
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v25 IgV

<400>  571

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  572
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v26 IgV

<400>  572

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  573
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v27 IgV

<400>  573

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  574
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v28 IgV

<400>  574

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  575
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v29 IgV

<400>  575

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  576
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v30 IgV

<400>  576

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Trp Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  577
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v31 IgV

<400>  577

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  578
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v32 IgV

<400>  578

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Trp Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  579
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v33 IgV

<400>  579

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  580
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v34 IgV

<400>  580

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  581
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v35 IgV

<400>  581

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  582
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v36 IgV

<400>  582

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Gln Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  583
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v37 IgV

<400>  583

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  584
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v38 IgV

<400>  584

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  585
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v39 IgV

<400>  585

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  586
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v40 IgV

<400>  586

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  587
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v41 IgV

<400>  587

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  588
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v42 IgV

<400>  588

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  589
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v43 IgV

<400>  589

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  590
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v44 IgV

<400>  590

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  591
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v45 IgV

<400>  591

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Met Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  592
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v46 IgV

<400>  592

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  593
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v47 IgV

<400>  593

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  594
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v48 IgV

<400>  594

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Leu Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  595
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v49 IgV

<400>  595

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  596
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v50 IgV

<400>  596

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  597
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v51 IgV

<400>  597

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  598
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v52 IgV

<400>  598

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  599
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v53 IgV

<400>  599

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  600
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v54 IgV

<400>  600

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  601
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v55 IgV

<400>  601

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  602
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v56 IgV

<400>  602

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  603
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v57 IgV

<400>  603

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  604
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v58 IgV

<400>  604

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  605
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v59 IgV

<400>  605

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  606
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v60 IgV

<400>  606

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Val Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  607
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v61 IgV

<400>  607

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  608
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v62 IgV

<400>  608

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  609
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v63 IgV

<400>  609

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Glu Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  610
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v64 IgV

<400>  610

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  611
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v65 IgV

<400>  611

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  612
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v66 IgV

<400>  612

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  613
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v67 IgV

<400>  613

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  614
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v68 IgV

<400>  614

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  615
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v69 IgV

<400>  615

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  616
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v70 IgV

<400>  616

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Ala His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro 
    50                  55                  60                  


Asn Tyr Leu Glu Ser Lys Arg Leu Gly Phe Val Ala Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  617
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v71 IgV

<400>  617

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro 
    50                  55                  60                  


Asn Tyr Leu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  618
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v72 IgV

<400>  618

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  619
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v73 IgV

<400>  619

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro 
    50                  55                  60                  


Asn Tyr Leu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Pro Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  620
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v74 IgV

<400>  620

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  621
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v75 IgV

<400>  621

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  622
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v76 IgV

<400>  622

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  623
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v77 IgV

<400>  623

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  624
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v78 IgV

<400>  624

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro 
    50                  55                  60                  


His Tyr His Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  625
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v79 IgV

<400>  625

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  626
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v80 IgV

<400>  626

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gly Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser 
65                  70                  75                  80  


Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  627
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v81 IgV

<400>  627

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Pro Val Thr His Val Pro Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  628
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v82 IgV

<400>  628

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  629
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v83 IgV

<400>  629

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Val Arg Leu Ser 
65                  70                  75                  80  


Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  630
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v84 IgV

<400>  630

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Ser Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser 
65                  70                  75                  80  


Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  631
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v85 IgV

<400>  631

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  632
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v86 IgV

<400>  632

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr His Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  633
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v87 IgV

<400>  633

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Lys Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  634
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v88 IgV

<400>  634

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  635
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v89 IgV

<400>  635

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  636
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v90 IgV

<400>  636

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Ala Phe His Gln Met Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Asp 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  637
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v91 IgV

<400>  637

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Thr Phe His Gln Ser Gln Gly Pro 
    50                  55                  60                  


Tyr Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  638
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v92 IgV

<400>  638

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  639
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v93 IgV

<400>  639

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Ala Phe His Gln Met Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  640
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v94 IgV

<400>  640

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Met Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  641
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v95 IgV

<400>  641

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Ala Gly Gln Leu Gly Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  642
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v96 IgV

<400>  642

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val His Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Ile Trp Ala Arg 
        35                  40                  45              


His Gly Glu Thr Arg His Met Ala Leu Phe Glu Gln Ser Gln Gly Pro 
    50                  55                  60                  


Asp Tyr Ser Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  643
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v97 IgV

<400>  643

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Val Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Leu His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Trp Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  644
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v98 IgV

<400>  644

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ile Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  645
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v99 IgV

<400>  645

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Gly Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Asn Phe Ala Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  646
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v100 IgV

<400>  646

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val His Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr Arg Val Gly Gln Leu Ile Trp Ala Arg 
        35                  40                  45              


His Gly Glu Thr Arg His Met Ala Leu Phe Glu Gln Ser Gln Gly Pro 
    50                  55                  60                  


Asp Tyr Ser Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Tyr Phe Leu Thr His Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  647
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v101 IgV

<400>  647

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Val Val Thr His Val Gly Gln Leu Gly Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  648
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v102 IgV

<400>  648

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  649
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v103 IgV

<400>  649

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  650
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v104 IgV

<400>  650

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Pro Val Thr His Val Leu Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gly Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  651
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v105 IgV

<400>  651

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asn Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  652
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v106 IgV

<400>  652

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser 
65                  70                  75                  80  


Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  653
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v107 IgV

<400>  653

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Thr Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  654
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v108 IgV

<400>  654

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Gly Gly Ser Met Ala Ala Phe His Gln Thr Met Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  655
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v109 IgV

<400>  655

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Val Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Asp Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  656
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v110 IgV

<400>  656

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro 
    50                  55                  60                  


Thr Tyr Ser Glu Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Gly Ser Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asn Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  657
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v111 IgV

<400>  657

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Pro Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Gly Gln Gly Pro 
    50                  55                  60                  


His Tyr Glu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asn Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  658
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v112 IgV

<400>  658

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro 
    50                  55                  60                  


Thr Tyr Ser Glu Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Ala Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  659
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v113 IgV

<400>  659

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg 
        35                  40                  45              


His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro 
    50                  55                  60                  


Thr Tyr Ser Gly Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Gly Ser Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  660
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v114 IgV

<400>  660

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  661
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v115 IgV

<400>  661

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg 
        35                  40                  45              


His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  662
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v116 IgV

<400>  662

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Asp Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  663
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v117 IgV

<400>  663

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ser Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Lys Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  664
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v118 IgV

<400>  664

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  665
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v119 IgV

<400>  665

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Val Phe Gly Leu Arg Ala Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  666
<211>  125
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD112 IgV

<400>  666

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  667
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v1 ECD

<400>  667

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Asp Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  668
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v2 ECD

<400>  668

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Ala Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Gly 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Gly 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Ser Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  669
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v3 ECD

<400>  669

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  670
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v4 ECD

<400>  670

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Val Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ile 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  671
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v5 ECD

<400>  671

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  672
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v6 ECD

<400>  672

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Asn Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Ala Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  673
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v7 ECD

<400>  673

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  674
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v8 ECD

<400>  674

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn Tyr 
        35                  40                  45              


Gln Asn Val Ala Ala Ser His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  675
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v9 ECD

<400>  675

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  676
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v10 ECD

<400>  676

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Ser Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  677
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v11 ECD

<400>  677

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  678
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v12 ECD

<400>  678

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  679
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v13 ECD

<400>  679

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  680
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v14 ECD

<400>  680

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Thr Pro 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  681
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v15 ECD

<400>  681

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Ser Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  682
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v16 ECD

<400>  682

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  683
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v17 ECD

<400>  683

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Ser Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  684
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v18 ECD

<400>  684

Gln Asp Val Arg Val Gln Val Leu Ser Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Ser His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  685
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v19 ECD

<400>  685

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys His Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  686
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v20 ECD

<400>  686

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Leu Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  687
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v21 ECD

<400>  687

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Asp Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  688
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v22 ECD

<400>  688

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Pro Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  689
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v23 ECD

<400>  689

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Ala Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  690
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v24 ECD

<400>  690

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Ser Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  691
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v25 ECD

<400>  691

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  692
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v26 ECD

<400>  692

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  693
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v27 ECD

<400>  693

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Arg Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Gly Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Ser Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  694
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v28 ECD

<400>  694

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Leu His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  695
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v29 ECD

<400>  695

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  696
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v30 ECD

<400>  696

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Val Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  697
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v31 ECD

<400>  697

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  698
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v32 ECD

<400>  698

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  699
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v33 ECD

<400>  699

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Met Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  700
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v34 ECD

<400>  700

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  701
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v35 ECD

<400>  701

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Ala Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Ser Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  702
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v36 ECD

<400>  702

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys Arg Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Asn Trp Gln Arg Pro Gly Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  703
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v37 ECD

<400>  703

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  704
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v38 ECD

<400>  704

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  705
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v39 ECD

<400>  705

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  706
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v40 ECD

<400>  706

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Ile Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  707
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v41 ECD

<400>  707

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  708
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v42 ECD

<400>  708

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  709
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v43 ECD

<400>  709

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  710
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v44 ECD

<400>  710

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Arg Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  711
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v45 ECD

<400>  711

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  712
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v46 ECD

<400>  712

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Ile Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  713
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v47 ECD

<400>  713

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Leu Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Met Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  714
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v1 IgV

<400>  714

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Asp Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  715
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v2 IgV

<400>  715

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Ala Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Gly 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Gly 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Ser Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  716
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v3 IgV

<400>  716

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  717
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v4 IgV

<400>  717

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Val Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ile 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  718
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v5 IgV

<400>  718

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  719
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v6 IgV

<400>  719

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Asn Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Ala Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  720
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v7 IgV

<400>  720

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  721
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v8 IgV

<400>  721

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn Tyr 
        35                  40                  45              


Gln Asn Val Ala Ala Ser His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  722
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v9 IgV

<400>  722

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  723
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v10 IgV

<400>  723

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Ser Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  724
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v11 IgV

<400>  724

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  725
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v12 IgV

<400>  725

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  726
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v13 IgV

<400>  726

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  727
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v14 IgV

<400>  727

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Thr Pro 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  728
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v15 IgV

<400>  728

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Ser Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  729
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v16 IgV

<400>  729

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  730
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v17 IgV

<400>  730

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Ser Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  731
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v18 IgV

<400>  731

Gln Asp Val Arg Val Gln Val Leu Ser Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Ser His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  732
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v19 IgV

<400>  732

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys His Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  733
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v20 IgV

<400>  733

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Leu Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  734
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v21 IgV

<400>  734

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Asp Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  735
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v22 IgV

<400>  735

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Pro Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  736
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v23 IgV

<400>  736

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Ala Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  737
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v24 IgV

<400>  737

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Ser Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  738
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v25 IgV

<400>  738

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  739
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v26 IgV

<400>  739

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  740
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v27 IgV

<400>  740

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Arg Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Gly Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Ser Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  741
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v28 IgV

<400>  741

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Leu His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  742
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v29 IgV

<400>  742

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  743
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v30 IgV

<400>  743

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Val Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  744
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v31 IgV

<400>  744

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  745
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v32 IgV

<400>  745

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  746
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v33 IgV

<400>  746

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Met Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  747
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v34 IgV

<400>  747

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  748
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v35 IgV

<400>  748

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Ala Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Ser Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  749
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v36 IgV

<400>  749

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys Arg Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Asn Trp Gln Arg Pro Gly Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  750
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v37 IgV

<400>  750

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  751
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v38 IgV

<400>  751

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  752
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v39 IgV

<400>  752

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  753
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v40 IgV

<400>  753

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Ile Thr Trp Leu 
        115                 120                 125 


<210>  754
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v41 IgV

<400>  754

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  755
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v42 IgV

<400>  755

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  756
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v43 IgV

<400>  756

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  757
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v44 IgV

<400>  757

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Arg Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  758
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v45 IgV

<400>  758

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  759
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v46 IgV

<400>  759

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Ile Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  760
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v47 IgV

<400>  760

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Leu Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Met Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  761
<211>  127
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD112 IgV Wildtype

<400>  761

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  762
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v1 IgV

<400>  762

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Asp Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  763
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v2 IgV

<400>  763

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Ala Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Gly 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Gly 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Ser Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  764
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v3 IgV

<400>  764

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  765
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v4 IgV

<400>  765

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Val Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ile 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  766
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v5 IgV

<400>  766

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  767
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v6 IgV

<400>  767

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Asn Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Ala Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  768
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v7 IgV

<400>  768

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  769
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v8 IgV

<400>  769

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn Tyr 
        35                  40                  45              


Gln Asn Val Ala Ala Ser His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  770
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v9 IgV

<400>  770

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  771
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v10 IgV

<400>  771

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Ser Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  772
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v11 IgV

<400>  772

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  773
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v12 IgV

<400>  773

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  774
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v13 IgV

<400>  774

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  775
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v14 IgV

<400>  775

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Thr Pro 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  776
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v15 IgV

<400>  776

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Ser Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  777
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v16 IgV

<400>  777

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  778
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v17 IgV

<400>  778

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Ser Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  779
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v18 IgV

<400>  779

Gln Asp Val Arg Val Gln Val Leu Ser Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Ser His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  780
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v19 IgV

<400>  780

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys His Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  781
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v20 IgV

<400>  781

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Leu Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  782
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v21 IgV

<400>  782

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Asp Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  783
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v22 IgV

<400>  783

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Pro Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  784
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v23 IgV

<400>  784

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Ala Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  785
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v24 IgV

<400>  785

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Ser Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  786
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v25 IgV

<400>  786

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  787
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v26 IgV

<400>  787

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  788
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v27 IgV

<400>  788

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Arg Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Gly Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Ser Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  789
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v28 IgV

<400>  789

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Leu His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  790
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v29 IgV

<400>  790

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  791
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v30 IgV

<400>  791

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Val Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  792
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v31 IgV

<400>  792

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  793
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v32 IgV

<400>  793

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  794
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v33 IgV

<400>  794

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Met Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  795
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v34 IgV

<400>  795

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  796
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v35 IgV

<400>  796

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Ala Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Ser Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  797
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v36 IgV

<400>  797

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys Arg Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Asn Trp Gln Arg Pro Gly Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  798
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v37 gV

<400>  798

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  799
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v38 gV

<400>  799

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  800
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v39 gV

<400>  800

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  801
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v40 gV

<400>  801

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Ile Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  802
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v41 gV

<400>  802

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  803
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v42 gV

<400>  803

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  804
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v43 gV

<400>  804

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  805
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v44 gV

<400>  805

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Arg Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  806
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v45 IgV

<400>  806

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  807
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v46 IgV

<400>  807

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Ile Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  808
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v47 IgV

<400>  808

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Leu Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Met Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  809
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v48 ECD

<400>  809

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  810
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v49 ECD

<400>  810

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Arg Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Thr Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  811
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v50 ECD

<400>  811

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Tyr Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  812
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v51 ECD

<400>  812

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Arg Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  813
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v52 ECD

<400>  813

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Met Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Ala Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  814
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v53 ECD

<400>  814

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  815
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v54 ECD

<400>  815

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  816
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v55 ECD

<400>  816

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Arg Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  817
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v56 ECD

<400>  817

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Arg Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  818
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v57 ECD

<400>  818

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  819
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v58 ECD

<400>  819

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  820
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v59 ECD

<400>  820

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Ala Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  821
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v60 ECD

<400>  821

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  822
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v61 ECD

<400>  822

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Met Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  823
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v62 ECD

<400>  823

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  824
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v63 ECD

<400>  824

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  825
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v64 ECD

<400>  825

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  826
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v65 ECD

<400>  826

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Ser Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Met Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  827
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v66 ECD

<400>  827

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Ala Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Glu Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  828
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v67 ECD

<400>  828

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Ala Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  829
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v68 ECD

<400>  829

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  830
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v69 ECD

<400>  830

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  831
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v70 ECD

<400>  831

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  832
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v71 ECD

<400>  832

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  833
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v72 ECD

<400>  833

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Ser Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  834
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v73 ECD

<400>  834

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  835
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v74 ECD

<400>  835

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  836
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v75 ECD

<400>  836

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  837
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v76 ECD

<400>  837

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Met Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  838
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v77 ECD

<400>  838

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Ala Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  839
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v78 ECD

<400>  839

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  840
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v79 ECD

<400>  840

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Gly Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  841
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v80 ECD

<400>  841

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  842
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v81 ECD

<400>  842

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  843
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v82 ECD

<400>  843

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Asp Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  844
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v83 ECD

<400>  844

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Ser Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  845
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v84 ECD

<400>  845

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Ser Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  846
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v85 ECD

<400>  846

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  847
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v86 ECD

<400>  847

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  848
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v87 ECD

<400>  848

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  849
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v88 ECD

<400>  849

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  850
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v48 IgV

<400>  850

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  851
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v49 IgV

<400>  851

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Arg Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Thr Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  852
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v50 IgV

<400>  852

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Tyr Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  853
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v51 IgV

<400>  853

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Arg Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  854
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v52 IgV

<400>  854

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Met Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Ala Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  855
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v53 IgV

<400>  855

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  856
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v54 IgV

<400>  856

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  857
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v55 IgV

<400>  857

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Arg Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  858
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v56 IgV

<400>  858

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Gly Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  859
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v57 IgV

<400>  859

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  860
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v58 IgV

<400>  860

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  861
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v59 IgV

<400>  861

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Ala Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  862
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v60 IgV

<400>  862

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  863
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v61 IgV

<400>  863

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Met Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  864
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v62 IgV

<400>  864

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  865
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v63 IgV

<400>  865

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  866
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v64 IgV

<400>  866

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  867
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v65 IgV

<400>  867

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Ser Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Met Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  868
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v66 IgV

<400>  868

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Ala Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Glu Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  869
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v67 IgV

<400>  869

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Ala Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  870
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v68 IgV

<400>  870

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  871
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v69 IgV

<400>  871

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  872
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v70 IgV

<400>  872

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  873
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v71 IgV

<400>  873

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  874
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v72 IgV

<400>  874

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Ser Met Thr Trp Leu 
        115                 120                 125 


<210>  875
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v73 IgV

<400>  875

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  876
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v74 IgV

<400>  876

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  877
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v75 IgV

<400>  877

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  878
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v76 IgV

<400>  878

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Met Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  879
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v77 IgV

<400>  879

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Ala Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  880
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v78 IgV

<400>  880

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  881
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v79 IgV

<400>  881

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Gly Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  882
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v80 IgV

<400>  882

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  883
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v81 IgV

<400>  883

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  884
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v82 IgV

<400>  884

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Asp Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  885
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v83 IgV

<400>  885

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Ser Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  886
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v84 IgV

<400>  886

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Ser Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  887
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v85 IgV

<400>  887

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  888
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v86 IgV

<400>  888

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  889
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v87 IgV

<400>  889

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  890
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v88 IgV

<400>  890

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  891
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v48 IgV

<400>  891

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  892
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v49 IgV

<400>  892

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Arg Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Thr Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  893
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v50 IgV

<400>  893

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Tyr Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  894
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v51 IgV

<400>  894

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Arg Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  895
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v52 IgV

<400>  895

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Met Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Ala Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  896
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v53 IgV

<400>  896

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  897
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v54 IgV

<400>  897

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  898
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v55 IgV

<400>  898

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Arg Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  899
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v56 IgV

<400>  899

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Gly Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  900
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v57 IgV

<400>  900

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  901
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v58 IgV

<400>  901

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  902
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v59 IgV

<400>  902

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Ala Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  903
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v60 IgV

<400>  903

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  904
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v61 IgV

<400>  904

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Met Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  905
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v62 IgV

<400>  905

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  906
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v63 IgV

<400>  906

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  907
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v64 IgV

<400>  907

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  908
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v65 IgV

<400>  908

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Ser Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Met Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  909
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v66 IgV

<400>  909

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Ala Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Glu Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  910
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v67 IgV

<400>  910

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Ala Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  911
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v68 IgV

<400>  911

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  912
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v69 IgV

<400>  912

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  913
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v70 IgV

<400>  913

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  914
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v71 IgV

<400>  914

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  915
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v72 IgV

<400>  915

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Ser Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  916
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v73 IgV

<400>  916

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  917
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v74 IgV

<400>  917

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  918
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v75 IgV

<400>  918

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  919
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v76 IgV

<400>  919

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Met Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  920
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v77 IgV

<400>  920

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Ala Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  921
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v78 IgV

<400>  921

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  922
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v79 IgV

<400>  922

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Gly Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  923
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v80 IgV

<400>  923

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  924
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v81 IgV

<400>  924

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  925
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v82 IgV

<400>  925

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Asp Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  926
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v83 IgV

<400>  926

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Ser Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  927
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v84 IgV

<400>  927

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Ser Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  928
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v85 IgV

<400>  928

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  929
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v86 IgV

<400>  929

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  930
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v87 IgV

<400>  930

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  931
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD112 v88 IgV

<400>  931

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  932
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v122 ECD

<400>  932

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  933
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v123 ECD

<400>  933

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Phe Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  934
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v124 ECD

<400>  934

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  935
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v125 ECD

<400>  935

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Thr Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  936
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v126 ECD

<400>  936

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Arg 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  937
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v127 ECD

<400>  937

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  938
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v128 ECD

<400>  938

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Arg Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  939
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v130 ECD

<400>  939

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Val Val Leu Thr Met Met Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  940
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v131 ECD

<400>  940

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Thr Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  941
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v132 ECD

<400>  941

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ile Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  942
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v133 ECD

<400>  942

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Gly Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  943
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v134 ECD

<400>  943

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ala Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Thr Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  944
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v135 ECD

<400>  944

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Met Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  945
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v136 ECD

<400>  945

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Pro Arg Pro Ser Asp Glu Gly Ile Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  946
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v137 ECD

<400>  946

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Ser Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  947
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v138 ECD

<400>  947

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Pro Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  948
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v139 ECD

<400>  948

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Pro Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  949
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v140 ECD

<400>  949

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Ser Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  950
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v141 ECD

<400>  950

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Pro Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Thr Val Ile Leu Ala Leu Arg Ser Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Gly Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Asp His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  951
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v142 ECD

<400>  951

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  952
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v143 ECD

<400>  952

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Ala Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Asn Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  953
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v144 ECD

<400>  953

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Lys Cys Val Val Leu Lys Tyr Glu Lys Asp Ser Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  954
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v145 ECD

<400>  954

Val Ile His Val Thr Lys Glu Val Lys Glu Val Val Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  955
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v146 ECD

<400>  955

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Glu Glu Lys Lys Met Val Leu Ala Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  956
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v147 ECD

<400>  956

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Ala Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  957
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v148 ECD

<400>  957

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  958
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v149 ECD

<400>  958

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  959
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v150 ECD

<400>  959

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Arg Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Ala Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  960
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v151 ECD

<400>  960

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Glu Lys Glu Lys Lys Met Val Leu Ala Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  961
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v152 ECD

<400>  961

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val His 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  962
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v153 ECD

<400>  962

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Ala Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  963
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v154 ECD

<400>  963

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Pro Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  964
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v155 ECD

<400>  964

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Ser Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  965
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v156 ECD


<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  X is a stop codon

<400>  965

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Xaa Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Asn Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Val Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  966
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v157 ECD

<400>  966

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  967
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v158 ECD

<400>  967

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  968
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v159 ECD

<400>  968

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Ile Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  969
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v160 ECD

<400>  969

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Ala Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  970
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v161 ECD

<400>  970

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  971
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v162 ECD

<400>  971

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Ile Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  972
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v163 ECD

<400>  972

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  973
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v164 ECD

<400>  973

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Lys His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  974
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v165 ECD

<400>  974

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  975
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v166 ECD

<400>  975

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  976
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v167 ECD

<400>  976

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Leu Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  977
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v168 ECD

<400>  977

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Ile Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  978
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v169 ECD

<400>  978

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Val Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  979
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v170 ECD

<400>  979

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  980
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v171 ECD

<400>  980

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  981
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v172 ECD

<400>  981

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  982
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v173 ECD

<400>  982

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Leu Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  983
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v174 ECD

<400>  983

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  984
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v175 ECD

<400>  984

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  985
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v176 ECD

<400>  985

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  986
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v177 ECD

<400>  986

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Phe Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Ile Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  987
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v178 ECD

<400>  987

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ala Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  988
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v179 ECD

<400>  988

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Thr Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  989
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v180 ECD

<400>  989

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  990
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v181 ECD

<400>  990

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Asp Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Val Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Val Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  991
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v182 ECD

<400>  991

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Met Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Lys His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  992
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v183 ECD

<400>  992

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Ile Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Phe Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  993
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v184 ECD

<400>  993

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  994
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v185 ECD

<400>  994

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  995
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v186 ECD

<400>  995

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Val Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  996
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v187 ECD

<400>  996

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  997
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v188 ECD

<400>  997

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Gly Glu Leu Ser Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  998
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v189 ECD

<400>  998

Val Ile His Val Thr Lys Glu Val Lys Glu Val Thr Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  999
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v190 ECD

<400>  999

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Leu Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser His Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  1000
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v191 ECD

<400>  1000

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Glu Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  1001
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v192 ECD

<400>  1001

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  1002
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v193 ECD

<400>  1002

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  1003
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v194 ECD

<400>  1003

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  1004
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v195 ECD

<400>  1004

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Leu Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Trp Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  1005
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 WT IgV

<400>  1005

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1006
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v122 IgV

<400>  1006

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1007
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v123 IgV

<400>  1007

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Phe Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1008
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v124 IgV

<400>  1008

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1009
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v125 IgV

<400>  1009

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Thr Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1010
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v126 IgV

<400>  1010

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Arg 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1011
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v127 IgV

<400>  1011

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1012
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v128 IgV

<400>  1012

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Arg Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1013
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v130 IgV

<400>  1013

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Val Val Leu Thr Met Met Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1014
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v131 IgV

<400>  1014

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Thr Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1015
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v132 IgV

<400>  1015

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ile Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1016
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v133 IgV

<400>  1016

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Gly Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1017
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v134 IgV

<400>  1017

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ala Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Thr Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1018
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v135 IgV

<400>  1018

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Met Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1019
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v136 IgV

<400>  1019

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Pro Arg Pro Ser Asp Glu Gly Ile Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1020
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v137 IgV

<400>  1020

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Ser Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1021
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v138 IgV

<400>  1021

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Pro Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1022
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v139 IgV

<400>  1022

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Pro Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1023
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v140 IgV

<400>  1023

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Ser Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1024
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v141 IgV

<400>  1024

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Pro Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Thr Val Ile Leu Ala Leu Arg Ser Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Gly Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Asp His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1025
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v142 IgV

<400>  1025

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1026
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v143 IgV

<400>  1026

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Ala Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Asn Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1027
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v144 IgV

<400>  1027

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Lys Cys Val Val Leu Lys Tyr Glu Lys Asp Ser Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1028
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v145 IgV

<400>  1028

Val Ile His Val Thr Lys Glu Val Lys Glu Val Val Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1029
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v146 IgV

<400>  1029

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Glu Glu Lys Lys Met Val Leu Ala Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1030
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v147 IgV

<400>  1030

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Ala Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1031
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v148 IgV

<400>  1031

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1032
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v149 IgV

<400>  1032

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1033
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v150 IgV

<400>  1033

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Arg Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Ala Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1034
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v151 IgV

<400>  1034

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Glu Lys Glu Lys Lys Met Val Leu Ala Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1035
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v152 IgV

<400>  1035

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val His 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1036
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v153 IgV

<400>  1036

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Ala Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1037
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v154 IgV

<400>  1037

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Pro Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1038
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v155 IgV

<400>  1038

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Ser Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1039
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v156 IgV


<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  X is a stop codon

<400>  1039

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Xaa Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Asn Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Val Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1040
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v157 IgV

<400>  1040

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1041
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v158 IgV

<400>  1041

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1042
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v159 IgV

<400>  1042

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Ile Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1043
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v160 IgV

<400>  1043

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Ala Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1044
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v161 IgV

<400>  1044

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1045
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v162 IgV

<400>  1045

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Ile Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1046
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v163 IgV

<400>  1046

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1047
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v164 IgV

<400>  1047

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Lys His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1048
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v165 IgV

<400>  1048

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1049
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v166 IgV

<400>  1049

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1050
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v167 IgV

<400>  1050

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Leu Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1051
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v168 IgV

<400>  1051

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Ile Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1052
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v169 IgV

<400>  1052

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Val Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1053
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v170 IgV

<400>  1053

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1054
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v171 IgV

<400>  1054

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1055
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v172 IgV

<400>  1055

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1056
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v173 IgV

<400>  1056

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Leu Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1057
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v174 IgV

<400>  1057

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1058
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v175 IgV

<400>  1058

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1059
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v176 IgV

<400>  1059

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1060
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v177 IgV

<400>  1060

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Phe Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Ile Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1061
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v178 IgV

<400>  1061

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ala Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1062
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v179 IgV

<400>  1062

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Thr Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1063
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v180 IgV

<400>  1063

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1064
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v181 IgV

<400>  1064

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Asp Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Val Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Val Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1065
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v182 IgV

<400>  1065

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Met Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Lys His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1066
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v183 IgV

<400>  1066

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Ile Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Phe Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1067
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v184 IgV

<400>  1067

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1068
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v185 IgV

<400>  1068

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1069
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v186 IgV

<400>  1069

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Val Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1070
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v187 IgV

<400>  1070

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1071
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v188 IgV

<400>  1071

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Gly Glu Leu Ser Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1072
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v189 IgV

<400>  1072

Val Ile His Val Thr Lys Glu Val Lys Glu Val Thr Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1073
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v190 IgV

<400>  1073

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Leu Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser His Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1074
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v191 IgV

<400>  1074

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Glu Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1075
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v192 IgV

<400>  1075

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1076
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v193 IgV

<400>  1076

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1077
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v194 IgV

<400>  1077

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1078
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v195 IgV

<400>  1078

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Leu Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Trp Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  1079
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 WT IgV

<400>  1079

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1080
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v122 IgV

<400>  1080

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1081
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v123 IgV

<400>  1081

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Phe Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1082
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v124 IgV

<400>  1082

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1083
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v125 IgV

<400>  1083

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Thr Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1084
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v126 IgV

<400>  1084

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Arg 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1085
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v127 IgV

<400>  1085

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1086
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v128 IgV

<400>  1086

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Arg Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1087
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v130 IgV

<400>  1087

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Val Val Leu Thr Met Met Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1088
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v131 IgV

<400>  1088

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Thr Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1089
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v132 IgV

<400>  1089

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ile Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1090
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v133 IgV

<400>  1090

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Gly Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1091
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v134 IgV

<400>  1091

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ala Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Thr Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1092
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v135 IgV

<400>  1092

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Met Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1093
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v136 IgV

<400>  1093

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Pro Arg Pro Ser Asp Glu Gly Ile Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1094
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v137 IgV

<400>  1094

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Ser Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1095
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v138 IgV

<400>  1095

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Pro Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1096
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v139 IgV

<400>  1096

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Pro Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1097
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v140 IgV

<400>  1097

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Ser Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1098
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v141 IgV

<400>  1098

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Pro Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Thr Val Ile Leu Ala Leu Arg Ser Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Gly Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Asp His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1099
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v142 IgV

<400>  1099

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1100
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v143 IgV

<400>  1100

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Ala Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Asn Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1101
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v144 IgV

<400>  1101

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Lys Cys Val Val Leu Lys Tyr Glu Lys Asp Ser Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1102
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v145 IgV

<400>  1102

Val Ile His Val Thr Lys Glu Val Lys Glu Val Val Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1103
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v146 IgV

<400>  1103

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Glu Glu Lys Lys Met Val Leu Ala Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1104
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v147 IgV

<400>  1104

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Ala Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1105
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v148 IgV

<400>  1105

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1106
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v149 IgV

<400>  1106

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1107
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v150 IgV

<400>  1107

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Arg Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Ala Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1108
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v151 IgV

<400>  1108

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Glu Lys Glu Lys Lys Met Val Leu Ala Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1109
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v152 IgV

<400>  1109

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val His 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1110
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v153 IgV

<400>  1110

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Ala Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1111
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v154 IgV

<400>  1111

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Pro Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1112
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v155 IgV

<400>  1112

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Ser Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1113
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v156 IgV


<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  X is a stop codon

<400>  1113

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Xaa Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Asn Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Val Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1114
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v157 IgV

<400>  1114

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1115
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v158 IgV

<400>  1115

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1116
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v159 IgV

<400>  1116

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Ile Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1117
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v160 IgV

<400>  1117

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Ala Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1118
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v161 IgV

<400>  1118

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1119
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v162 IgV

<400>  1119

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Ile Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1120
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v163 IgV

<400>  1120

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1121
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v164 IgV

<400>  1121

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Lys His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1122
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v165 IgV

<400>  1122

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1123
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v166 IgV

<400>  1123

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1124
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v167 IgV

<400>  1124

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Leu Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1125
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v168 IgV

<400>  1125

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Ile Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1126
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v169 IgV

<400>  1126

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Val Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1127
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v170 IgV

<400>  1127

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1128
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v171 IgV

<400>  1128

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1129
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v172 IgV

<400>  1129

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1130
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v173 IgV

<400>  1130

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Leu Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1131
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v174 IgV

<400>  1131

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1132
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v175 IgV

<400>  1132

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1133
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v176 IgV

<400>  1133

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1134
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v177 IgV

<400>  1134

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Phe Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Ile Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1135
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v178 IgV

<400>  1135

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ala Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1136
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v179 IgV

<400>  1136

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Thr Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1137
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v180 IgV

<400>  1137

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1138
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v181 IgV

<400>  1138

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Asp Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Val Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Val Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1139
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v182 IgV

<400>  1139

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Met Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Lys His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1140
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v183 IgV

<400>  1140

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Ile Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Phe Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1141
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v184 IgV

<400>  1141

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1142
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v185 IgV

<400>  1142

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1143
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v186 IgV

<400>  1143

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Val Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1144
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v187 IgV

<400>  1144

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1145
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v188 IgV

<400>  1145

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Gly Glu Leu Ser Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1146
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v189 IgV

<400>  1146

Val Ile His Val Thr Lys Glu Val Lys Glu Val Thr Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1147
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v190 IgV

<400>  1147

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Leu Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser His Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1148
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v191 IgV

<400>  1148

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Glu Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1149
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v192 IgV

<400>  1149

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1150
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v193 IgV

<400>  1150

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1151
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v194 IgV

<400>  1151

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1152
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v195 IgV

<400>  1152

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Leu Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Trp Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  1153
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Knob Fc

<400>  1153

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  1154
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hole Fc

<400>  1154

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  1155
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stack Fc (homodimeric)

<400>  1155

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  1156
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stuffer

<400>  1156

His Met Ser Ser Val Ser Ala Gln 
1               5               


<210>  1157
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc (C5S (C220S), R77C, (R292C),  N82G (N297G), V87C (V302C))

<400>  1157

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln 
65                  70                  75                  80  


Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  1158
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc with C220S/L234A/L235E/G237A

<400>  1158

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  1159
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc with C220S/E233P/L234V/L235A/G236del/S267K

<400>  1159

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Lys His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  1160
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antiCD19z chimeric antigen receptor

<400>  1160

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ala Ala Lys Pro Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
305                 310                 315                 320 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                325                 330                 335     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            340                 345                 350         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        355                 360                 365             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    370                 375                 380                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
385                 390                 395                 400 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                405                 410                 415     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430     


<210>  1161
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-derived signal sequence

<400>  1161

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  1162
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-derived signal sequence

<400>  1162

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser 
            20              


<210>  1163
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFv

<400>  1163

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  1164
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-derived hinge and transmembrane domain

<400>  1164

Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr 
65                  


<210>  1165
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB-derived costimulatory domain

<400>  1165

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  1166
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28-derived costimulatory domain

<400>  1166

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210>  1167
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28-derived costimulatory domain

<400>  1167

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  1168
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28-derived costimulatory domain

<400>  1168

Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
1               5                   10                  15      


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            20                  25                  30          


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40                  


<210>  1169
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A protein

<400>  1169

Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  1170
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Blue fluorescent protein

<400>  1170

Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly 
1               5                   10                  15      


Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys 
            20                  25                  30          


Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly 
        35                  40                  45              


Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly 
    50                  55                  60                  


Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys 
65                  70                  75                  80  


Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu 
                85                  90                  95      


Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly 
            100                 105                 110         


Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn 
        115                 120                 125             


Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu 
    130                 135                 140                 


Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala 
145                 150                 155                 160 


Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr 
                165                 170                 175     


Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr 
            180                 185                 190         


Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr 
        195                 200                 205             


Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro 
    210                 215                 220                 


Ser Lys Leu Gly His Lys Leu Asn 
225                 230         


<210>  1171
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2nd Gen CAR

<400>  1171

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Met His Lys Arg 
305                 310                 315                 320 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                325                 330                 335     


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
            340                 345                 350         


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
        355                 360                 365             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    370                 375                 380                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
385                 390                 395                 400 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                405                 410                 415     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            420                 425                 430         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        435                 440                 445             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    450                 455                 460                 


His Met Gln Ala Leu Pro Pro Arg 
465                 470         


<210>  1172
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2nd Gen CAR

<400>  1172

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Met His Lys Arg 
305                 310                 315                 320 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                325                 330                 335     


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
            340                 345                 350         


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
        355                 360                 365             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    370                 375                 380                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
385                 390                 395                 400 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                405                 410                 415     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            420                 425                 430         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        435                 440                 445             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    450                 455                 460                 


His Met Gln Ala Leu Pro Pro Arg Gly Gly Arg Ser Gly Glu Gly Arg 
465                 470                 475                 480 


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser 
                485                 490                 495     


Arg 
    


<210>  1173
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2nd Gen CAR with CD28-derived costimulatory domain

<400>  1173

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Met His Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
        355                 360                 365             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    370                 375                 380                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
385                 390                 395                 400 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 


Met Gln Ala Leu Pro Pro Arg 
465                 470     


<210>  1174
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD19 scFv

<400>  1174

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ala Ala 
                245             


<210>  1175
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antiCD19x8z chimeric antigen receptor nucleotide

<400>  1175
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc      420

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc      480

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta      540

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt      600

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc      660

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac      720

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc      780

tcagtcaccg tctcctcagc ggccgcaaag cccaccacga cgccagcgcc gcgaccacca      840

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gagccggcca      900

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg ccagtgatat ctacatctgg      960

gcgcccctgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     1020

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc     1080

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1140

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1200

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1260

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1320

tacgacgccc ttcacatgca ggccctgccc cctcgc                               1356


<210>  1176
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A Nucleotide

<400>  1176
ggcagtggcg agggcagagg aagtctgcta acatgcggtg acgtcgagga gaatcctggc       60

cca                                                                     63


<210>  1177
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A Protein

<400>  1177

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  1178
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKp30 v1 ECD

<400>  1178

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Val Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Val Pro Leu Ala Pro 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Gly Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         


His Pro Gln Leu Gly 
        115         


<210>  1179
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKp30 v2 ECD

<400>  1179

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Val Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         


His Pro Gln Leu Gly 
        115         


<210>  1180
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKp30 v3 ECD

<400>  1180

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Val Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         


His Pro Gln Leu Gly 
        115         


<210>  1181
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKp30 v4 ECD

<400>  1181

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Pro 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         


His Pro Gln Leu Gly 
        115         


<210>  1182
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKp30 v5 ECD

<400>  1182

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Gly Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         


His Pro Gln Leu Gly 
        115         


<210>  1183
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKp30 WT IgC-like

<400>  1183

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val 
            100                 105             


<210>  1184
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKp30 v1 IgC-like

<400>  1184

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Val Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Val Pro Leu Ala Pro 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Gly Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val 
            100                 105             


<210>  1185
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKp30 v2 IgC-like

<400>  1185

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Val Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val 
            100                 105             


<210>  1186
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKp30 v3 IgC-like

<400>  1186

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Val Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val 
            100                 105             


<210>  1187
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKp30 v4 IgC-like

<400>  1187

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Pro 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val 
            100                 105             


<210>  1188
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKp30 v5 IgC-like

<400>  1188

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Gly Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val 
            100                 105             


<210>  1189
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nkp30 stack

<400>  1189

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Trp Val Ser Gln Pro Pro 
    130                 135                 140                 


Glu Ile Arg Thr Leu Glu Gly Ser Ser Ala Phe Leu Pro Cys Ser Phe 
145                 150                 155                 160 


Asn Ala Ser Gln Gly Arg Val Ala Ile Gly Ser Val Thr Trp Phe Arg 
                165                 170                 175     


Asp Glu Val Val Pro Gly Lys Glu Val Arg Asn Gly Thr Pro Glu Phe 
            180                 185                 190         


Arg Gly Arg Leu Val Pro Leu Ala Pro Ser Arg Phe Leu His Asp His 
        195                 200                 205             


Gln Ala Glu Leu His Ile Arg Asp Val Arg Gly His Asp Ala Gly Ile 
    210                 215                 220                 


Tyr Val Cys Arg Val Glu Val Leu Gly Leu Gly Val Gly Thr Gly Asn 
225                 230                 235                 240 


Gly Thr Arg Leu Val Val Glu Lys Glu His Pro Gln Leu Gly Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala Glu Pro Lys 
            260                 265                 270 


<210>  1190
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKp30 v1 IgC-like (long)

<400>  1190

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Val Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Val Pro Leu Ala Pro 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Gly Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         


His Pro Gln Leu 
        115     


<210>  1191
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 v1 ECD

<400>  1191

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp His Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile Leu His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His His Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


<210>  1192
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 v2 ECD

<400>  1192

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp His Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


<210>  1193
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 v3 ECD

<400>  1193

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile Leu His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


<210>  1194
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 v4 ECD

<400>  1194

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His His Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


<210>  1195
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 WT IgV

<400>  1195

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser 
            100                 105             


<210>  1196
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 v1 IgV

<400>  1196

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp His Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile Leu His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His His Met Asn Ser Glu Leu Ser 
            100                 105             


<210>  1197
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 v2 IgV

<400>  1197

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp His Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser 
            100                 105             


<210>  1198
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 v3 IgV

<400>  1198

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile Leu His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser 
            100                 105             


<210>  1199
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 v4 IgV

<400>  1199

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His His Met Asn Ser Glu Leu Ser 
            100                 105             


<210>  1200
<211>  229
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG4 Fc

<400>  1200

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  1201
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc S228P

<400>  1201

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  1202
<211>  232
<212>  PRT
<213>  artificial Sequence

<220>
<223>  IgG1 Fc C220S

<400>  1202

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  1203
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV

<400>  1203

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1204
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v1

<400>  1204

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1205
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v2

<400>  1205

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asp Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1206
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v3

<400>  1206

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1207
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v4

<400>  1207

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1208
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v5

<400>  1208

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1209
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v6

<400>  1209

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Gly Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1210
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v7

<400>  1210

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1211
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v8

<400>  1211

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1212
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v9

<400>  1212

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1213
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v10

<400>  1213

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1214
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v11

<400>  1214

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1215
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v12

<400>  1215

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1216
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v13

<400>  1216

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1217
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v14

<400>  1217

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1218
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v15

<400>  1218

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1219
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v16

<400>  1219

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1220
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v17

<400>  1220

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Ser Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1221
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v18

<400>  1221

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1222
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v19

<400>  1222

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1223
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v20

<400>  1223

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Arg Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1224
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v21

<400>  1224

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1225
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v22

<400>  1225

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1226
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v23

<400>  1226

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1227
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v24

<400>  1227

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1228
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v25

<400>  1228

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1229
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v26

<400>  1229

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1230
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v27

<400>  1230

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1231
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v28

<400>  1231

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1232
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v29

<400>  1232

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1233
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v30

<400>  1233

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1234
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v31

<400>  1234

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1235
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v32

<400>  1235

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1236
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v33

<400>  1236

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1237
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v34

<400>  1237

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1238
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v35

<400>  1238

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1239
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v36

<400>  1239

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asp 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1240
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v37

<400>  1240

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asp 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1241
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v38

<400>  1241

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1242
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v39

<400>  1242

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Arg Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1243
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v40

<400>  1243

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Val Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1244
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v41

<400>  1244

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1245
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v42

<400>  1245

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro His Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1246
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v43

<400>  1246

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1247
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v44

<400>  1247

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1248
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v45

<400>  1248

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1249
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v46

<400>  1249

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1250
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v47

<400>  1250

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1251
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v48

<400>  1251

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1252
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v49

<400>  1252

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Met Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1253
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v50

<400>  1253

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1254
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v51

<400>  1254

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Ala Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Ser Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1255
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v52


<220>
<221>  VARIANT
<222>  (65)..(65)
<223>  X is a stop codon

<400>  1255

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly 
1               5                   10                  15      


Ser Asn Val Ala Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Xaa Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1256
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v53

<400>  1256

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe Leu Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1257
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v54

<400>  1257

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe Leu Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1258
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v55

<400>  1258

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Val Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1259
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v56

<400>  1259

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asn Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1260
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v57

<400>  1260

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1261
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v58

<400>  1261

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1262
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v59

<400>  1262

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asp Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1263
<211>  102
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PD-L2 IgV wildtype

<400>  1263

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1264
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v61

<400>  1264

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Val Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1265
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v62

<400>  1265

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1266
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v63

<400>  1266

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Pro Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Ser Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1267
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v64

<400>  1267

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1268
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v65

<400>  1268

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1269
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v66

<400>  1269

Leu Leu Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Glu Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1270
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v67

<400>  1270

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Phe Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1271
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v68

<400>  1271

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Gly Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1272
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v69

<400>  1272

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Ser Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1273
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v70

<400>  1273

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Val Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1274
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v71

<400>  1274

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asp Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Ala Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1275
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v72

<400>  1275

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Ala Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Cys 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1276
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v73

<400>  1276

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


His Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1277
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v74

<400>  1277

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1278
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v75

<400>  1278

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Gly Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1279
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v76

<400>  1279

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1280
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 ECD v77

<400>  1280

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  1281
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v1

<400>  1281

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1282
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v2

<400>  1282

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asp Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1283
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v3

<400>  1283

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1284
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v4

<400>  1284

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1285
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v5

<400>  1285

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1286
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v6

<400>  1286

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Gly Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1287
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v7

<400>  1287

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1288
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v8

<400>  1288

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1289
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v9

<400>  1289

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1290
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v10

<400>  1290

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1291
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v11

<400>  1291

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Arg 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1292
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v12

<400>  1292

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro His Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1293
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v13

<400>  1293

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1294
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v14

<400>  1294

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1295
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v15

<400>  1295

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1296
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v16

<400>  1296

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1297
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v17

<400>  1297

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Ser Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1298
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v18

<400>  1298

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1299
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v19

<400>  1299

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1300
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v20

<400>  1300

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Arg Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1301
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v21

<400>  1301

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1302
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v22

<400>  1302

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1303
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v23

<400>  1303

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1304
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v24

<400>  1304

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1305
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v25

<400>  1305

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1306
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v26

<400>  1306

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1307
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v27

<400>  1307

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1308
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v28

<400>  1308

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1309
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v29

<400>  1309

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1310
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v30

<400>  1310

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1311
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v31

<400>  1311

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1312
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v32

<400>  1312

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1313
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v33

<400>  1313

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1314
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v34

<400>  1314

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1315
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v35

<400>  1315

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1316
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v36

<400>  1316

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asp Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1317
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v37

<400>  1317

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asp Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1318
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v38

<400>  1318

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1319
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v39

<400>  1319

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro His Val Arg Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1320
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v40

<400>  1320

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Val Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1321
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v41

<400>  1321

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1322
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v42

<400>  1322

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro His Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1323
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v43

<400>  1323

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1324
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v44

<400>  1324

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1325
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v45

<400>  1325

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1326
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v46

<400>  1326

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1327
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v47

<400>  1327

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1328
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v48

<400>  1328

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1329
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v49

<400>  1329

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Met Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1330
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v50

<400>  1330

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1331
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v51

<400>  1331

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Ala Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Ser Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1332
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v52


<220>
<221>  VARIANT
<222>  (64)..(64)
<223>  X is a stop codon

<400>  1332

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly Ser 
1               5                   10                  15      


Asn Val Ala Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Xaa 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1333
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v53

<400>  1333

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe Leu Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1334
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v54

<400>  1334

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe Leu Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1335
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v55

<400>  1335

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Val Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1336
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v56

<400>  1336

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asn Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1337
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v57

<400>  1337

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1338
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v58

<400>  1338

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1339
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v60

<400>  1339

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asp Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1340
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v61

<400>  1340

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Val Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1341
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v62

<400>  1341

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Arg 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1342
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v63

<400>  1342

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Pro 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Ser Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1343
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v64

<400>  1343

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1344
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v65

<400>  1344

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1345
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v66

<400>  1345

Leu Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Glu Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1346
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v67

<400>  1346

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Phe 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1347
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v68

<400>  1347

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Gly Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1348
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v69

<400>  1348

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Ser Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1349
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v70

<400>  1349

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Val Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1350
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v71

<400>  1350

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asp Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro His Ala Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Thr Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1351
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v72

<400>  1351

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Ala Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Cys Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1352
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v73

<400>  1352

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn His 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1353
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v74

<400>  1353

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1354
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v75

<400>  1354

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Ser Phe His Ile Pro His Val Gln Gly Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1355
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v76

<400>  1355

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1356
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v77

<400>  1356

Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser 
1               5                   10                  15      


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
            20                  25                  30          


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro 
        35                  40                  45              


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
    50                  55                  60                  


Ala Leu Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr 
65                  70                  75                  80  


Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr 
                85                  90                  95      


Leu Lys 
        


<210>  1357
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v1

<400>  1357

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1358
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v2

<400>  1358

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asp Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1359
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v3

<400>  1359

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1360
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v4

<400>  1360

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1361
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v5

<400>  1361

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1362
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v6

<400>  1362

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Gly Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1363
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v7

<400>  1363

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1364
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v8

<400>  1364

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1365
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v9

<400>  1365

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1366
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v10

<400>  1366

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1367
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v11

<400>  1367

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1368
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v12

<400>  1368

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1369
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v13

<400>  1369

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1370
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v14

<400>  1370

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1371
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v15

<400>  1371

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1372
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v16

<400>  1372

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1373
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v17

<400>  1373

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Ser Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1374
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v18

<400>  1374

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1375
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v19

<400>  1375

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1376
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v20

<400>  1376

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Arg Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1377
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v21

<400>  1377

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1378
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v22

<400>  1378

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1379
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v23

<400>  1379

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1380
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v24

<400>  1380

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1381
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v25

<400>  1381

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1382
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v26

<400>  1382

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1383
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v27

<400>  1383

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1384
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v28

<400>  1384

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1385
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v29

<400>  1385

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1386
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v30

<400>  1386

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1387
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v31

<400>  1387

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1388
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v32

<400>  1388

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1389
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v33

<400>  1389

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1390
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v34

<400>  1390

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1391
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v35

<400>  1391

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1392
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v36

<400>  1392

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asp 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1393
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v37

<400>  1393

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asp 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1394
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v38

<400>  1394

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1395
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v39

<400>  1395

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Arg Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1396
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v40

<400>  1396

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Val Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1397
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v41

<400>  1397

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1398
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v42

<400>  1398

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro His Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1399
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v43

<400>  1399

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1400
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v44

<400>  1400

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1401
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v45

<400>  1401

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1402
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v46

<400>  1402

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1403
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v47

<400>  1403

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1404
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v48

<400>  1404

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1405
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v49

<400>  1405

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Met Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1406
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v50

<400>  1406

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1407
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v51

<400>  1407

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Ala Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Ser Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1408
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v52


<220>
<221>  VARIANT
<222>  (65)..(65)
<223>  X is a stop codon

<400>  1408

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly 
1               5                   10                  15      


Ser Asn Val Ala Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Xaa Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1409
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v53

<400>  1409

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe Leu Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1410
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v54

<400>  1410

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe Leu Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1411
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v55

<400>  1411

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Val Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1412
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v56

<400>  1412

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asn Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1413
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v57

<400>  1413

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1414
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v58

<400>  1414

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1415
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v60

<400>  1415

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asp Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1416
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v61

<400>  1416

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Val Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1417
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v62

<400>  1417

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1418
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v63

<400>  1418

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Pro Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Ser Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1419
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v64

<400>  1419

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1420
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v65

<400>  1420

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1421
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v66

<400>  1421

Leu Leu Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Glu Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1422
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v67

<400>  1422

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Phe Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1423
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v68

<400>  1423

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Gly Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1424
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v69

<400>  1424

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Ser Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1425
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v70

<400>  1425

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Val Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1426
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v71

<400>  1426

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asp Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Ala Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1427
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v72

<400>  1427

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Ala Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Cys 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1428
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v73

<400>  1428

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


His Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1429
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v74

<400>  1429

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1430
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v75

<400>  1430

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro His Val Gln Gly Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1431
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v76

<400>  1431

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1432
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 IgV v77

<400>  1432

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Leu Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala 
            100         


<210>  1433
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v89 ECD

<400>  1433

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1434
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v90 ECD

<400>  1434

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Met Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1435
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v91 ECD

<400>  1435

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1436
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v92 ECD

<400>  1436

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1437
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v93 ECD

<400>  1437

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Leu Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1438
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v94 ECD

<400>  1438

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1439
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v95 ECD

<400>  1439

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Ala Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1440
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v96 ECD

<400>  1440

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1441
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v97 ECD

<400>  1441

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Pro Ala Lys Gln Ser 
65                  70                  75                  80  


Ile Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1442
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v98 ECD

<400>  1442

Gln Asp Val Arg Val Gln Val Leu Arg Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Val Leu Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Met Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Phe Glu Arg Leu Ser Leu Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Val Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Ala Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1443
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v99 ECD

<400>  1443

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1444
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v100 ECD

<400>  1444

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Ala Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1445
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v101 ECD

<400>  1445

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1446
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v102 ECD

<400>  1446

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1447
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v103 ECD

<400>  1447

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1448
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v104 ECD

<400>  1448

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Leu Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1449
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v105 ECD

<400>  1449

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Ala Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1450
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v106 ECD

<400>  1450

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Pro Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1451
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v107 ECD

<400>  1451

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Leu Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1452
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v108 ECD

<400>  1452

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Ser Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Leu Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1453
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v109 ECD

<400>  1453

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Ala Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1454
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v100 ECD

<400>  1454

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1455
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v111 ECD

<400>  1455

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Met Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Leu Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1456
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v112 ECD

<400>  1456

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  1457
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v89 IgV

<400>  1457

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1458
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v90 IgV

<400>  1458

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Met Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1459
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v91 IgV

<400>  1459

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1460
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v92 IgV

<400>  1460

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1461
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v93 IgV

<400>  1461

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Leu Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1462
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v94 IgV

<400>  1462

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1463
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v95 IgV

<400>  1463

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Ala Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1464
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v96 IgV

<400>  1464

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1465
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v97 IgV

<400>  1465

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Pro Ala Lys Gln Ser 
65                  70                  75                  80  


Ile Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1466
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v98 IgV

<400>  1466

Gln Asp Val Arg Val Gln Val Leu Arg Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Val Leu Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Met Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Phe Glu Arg Leu Ser Leu Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Val Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Ala 
        115                 120                 125 


<210>  1467
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v99 IgV

<400>  1467

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1468
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v100 IgV

<400>  1468

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Ala Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1469
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v101 IgV

<400>  1469

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1470
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v102 IgV

<400>  1470

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1471
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v103 IgV

<400>  1471

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1472
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v104 IgV

<400>  1472

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Leu Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1473
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v105 IgV

<400>  1473

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Ala Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1474
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v106 IgV

<400>  1474

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Pro Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1475
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v107 IgV

<400>  1475

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Leu Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1476
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v108 IgV

<400>  1476

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Ser Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Leu Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1477
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v109 IgV

<400>  1477

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Ala Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1478
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v100 IgV

<400>  1478

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1479
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v111 IgV

<400>  1479

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Met Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Leu Leu 
        115                 120                 125 


<210>  1480
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v112 IgV

<400>  1480

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu 
        115                 120                 125 


<210>  1481
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v89 IgV

<400>  1481

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1482
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v90 IgV

<400>  1482

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Met Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1483
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v91 IgV

<400>  1483

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1484
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v92 IgV

<400>  1484

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1485
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v93 IgV

<400>  1485

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Leu Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1486
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v94 IgV

<400>  1486

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1487
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v95 IgV

<400>  1487

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Ala Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1488
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v96 IgV

<400>  1488

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1489
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v97 IgV

<400>  1489

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Pro Ala Lys Gln Ser 
65                  70                  75                  80  


Ile Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1490
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v98 IgV

<400>  1490

Gln Asp Val Arg Val Gln Val Leu Arg Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Val Leu Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Met Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Phe Glu Arg Leu Ser Leu Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Val Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Ala Arg Val 
        115                 120                 125         


<210>  1491
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v99 IgV

<400>  1491

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1492
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v100 IgV

<400>  1492

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Ala Pro Gly Pro 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1493
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v101 IgV

<400>  1493

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1494
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v102 IgV

<400>  1494

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1495
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v103 IgV

<400>  1495

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1496
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v104 IgV

<400>  1496

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Leu Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1497
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v105 IgV

<400>  1497

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Ala Trp Gln Arg Pro Asp Ala Pro Thr Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1498
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v106 IgV

<400>  1498

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Pro Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1499
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v107 IgV

<400>  1499

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Leu Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1500
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v109 IgV

<400>  1500

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Ser Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Leu Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1501
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v109 IgV

<400>  1501

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Thr Ala Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1502
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v100 IgV

<400>  1502

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1503
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v111 IgV

<400>  1503

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Met Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Leu Leu Arg Val 
        115                 120                 125         


<210>  1504
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD112 v112 IgV

<400>  1504

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val 
        115                 120                 125         


<210>  1505
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v120 IgV

<400>  1505

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Gly Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Ala Phe Pro Gln Gly Ser Trp Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1506
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v121 IgV

<400>  1506

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Gly Ala Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asp 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg Leu Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1507
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v122 IgV

<400>  1507

Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Arg Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Leu Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Lys Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1508
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v123 IgV

<400>  1508

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg Arg Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Asp Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Ala Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1509
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v124 IgV

<400>  1509

Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1510
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v125 IgV

<400>  1510

Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Arg Met Ala Val Phe His Pro Thr Lys Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1511
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v126 IgV

<400>  1511

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1512
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v127 IgV

<400>  1512

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1513
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v128 IgV

<400>  1513

Pro Gly Thr Gly Gly Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Ile Glu Ala Thr His Val Ser Gln Leu Thr Trp Ala Arg Gln Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Glu Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Ala Phe Pro Gln Gly Ser Trp Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1514
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v129 IgV

<400>  1514

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Ser Phe Pro Gln Gly Ser Trp Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1515
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v130 IgV

<400>  1515

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ile Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1516
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v131 IgV

<400>  1516

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Asp Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Asp Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1517
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v132 IgV

<400>  1517

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Gly Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Arg Ser Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Asp Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1518
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v133 IgV

<400>  1518

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Ala Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1519
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v134 IgV

<400>  1519

Pro Gly Thr Gly Asp Ile Val Val Lys Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Arg Ile Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1520
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v135 IgV

<400>  1520

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1521
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v136 IgV

<400>  1521

Pro Gly Thr Gly Asp Ile Ile Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Ser Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Tyr Pro Gln Arg Val Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1522
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v137 IgV

<400>  1522

Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln Val Leu Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Ile Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Ser Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1523
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v138 IgV

<400>  1523

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Cys Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1524
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v139 IgV

<400>  1524

Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Gly Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1525
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v140 IgV

<400>  1525

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Leu Ser Gly Leu Arg Ala Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1526
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v141 IgV

<400>  1526

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Glu 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly Thr Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1527
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v142 IgV

<400>  1527

Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1528
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v120 IgV

<400>  1528

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Gly Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Ala Phe Pro Gln Gly Ser 
            100                 105                 110         


Trp Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1529
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v121 IgV

<400>  1529

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Gly Ala Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asp Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Leu Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1530
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v122 IgV

<400>  1530

Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Arg Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Leu Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Lys Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1531
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v123 IgV

<400>  1531

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Asp Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Ala Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1532
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v124 IgV

<400>  1532

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1533
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v125 IgV

<400>  1533

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Arg Met Ala Val Phe His Pro Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1534
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v126 IgV

<400>  1534

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1535
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v127 IgV

<400>  1535

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1536
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v128 IgV

<400>  1536

Trp Pro Pro Pro Gly Thr Gly Gly Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Ile Glu Ala Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Gln Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Glu Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Ala Phe Pro Gln Gly Ser 
            100                 105                 110         


Trp Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1537
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v129 IgV

<400>  1537

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Ser Phe Pro Gln Gly Ser 
            100                 105                 110         


Trp Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1538
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v130 IgV

<400>  1538

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ile Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1539
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v131 IgV

<400>  1539

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Asp Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Asp Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1540
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v132 IgV

<400>  1540

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Gly Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Arg Ser Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Asp Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1541
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v133 IgV

<400>  1541

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Ala Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1542
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v134 IgV

<400>  1542

Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Lys Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Arg Ile 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1543
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v135 IgV

<400>  1543

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1544
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v136 IgV

<400>  1544

Trp Pro Pro Pro Gly Thr Gly Asp Ile Ile Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Ser Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Tyr Pro Gln Arg Val 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1545
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v137 IgV

<400>  1545

Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Ile Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Ser Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1546
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v138 IgV

<400>  1546

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Cys Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1547
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v139 IgV

<400>  1547

Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Gly Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1548
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v140 IgV

<400>  1548

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Leu Ser Gly Leu Arg Ala Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1549
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v141 IgV

<400>  1549

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Glu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly 
65                  70                  75                  80  


Thr Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1550
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v142 IgV

<400>  1550

Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1551
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v120 ECD

<400>  1551

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Gly Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Ala Phe Pro Gln Gly Ser 
            100                 105                 110         


Trp Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1552
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v121 ECD

<400>  1552

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Gly Ala Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asp Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Leu Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1553
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v122 ECD

<400>  1553

Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Arg Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Leu Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Lys Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1554
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v123 ECD

<400>  1554

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Asp Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Ala Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1555
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v124 ECD

<400>  1555

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1556
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v125 ECD

<400>  1556

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Arg Met Ala Val Phe His Pro Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1557
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v126 ECD

<400>  1557

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1558
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v127 ECD

<400>  1558

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1559
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v128 ECD

<400>  1559

Trp Pro Pro Pro Gly Thr Gly Gly Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Ile Glu Ala Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Gln Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Glu Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Ala Phe Pro Gln Gly Ser 
            100                 105                 110         


Trp Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1560
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v129 ECD

<400>  1560

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Ser Phe Pro Gln Gly Ser 
            100                 105                 110         


Trp Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1561
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v130 ECD

<400>  1561

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ile Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1562
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v131 ECD

<400>  1562

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Asp Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Asp Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1563
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v132 ECD

<400>  1563

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Gly Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Arg Ser Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Asp Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1564
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v133 ECD

<400>  1564

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Ala Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1565
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v134 ECD

<400>  1565

Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Lys Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Arg Ile 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1566
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v135 ECD

<400>  1566

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1567
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v136 ECD

<400>  1567

Trp Pro Pro Pro Gly Thr Gly Asp Ile Ile Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Ser Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Tyr Pro Gln Arg Val 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1568
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v137 ECD

<400>  1568

Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Ile Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Ser Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1569
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v138 ECD

<400>  1569

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Cys Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1570
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v139 ECD

<400>  1570

Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Gly Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1571
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v140 ECD

<400>  1571

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Leu Ser Gly Leu Arg Ala Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1572
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v141 ECD

<400>  1572

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Glu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly 
65                  70                  75                  80  


Thr Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1573
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v142 ECD

<400>  1573

Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1574
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v143 ECD

<400>  1574

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1575
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v143 IgV

<400>  1575

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Trp Tyr Ala 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1576
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v143 IgV

<400>  1576

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1577
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v144 ECD

<400>  1577

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Asp Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Asn Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Gln Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Tyr Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1578
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v145 ECD

<400>  1578

Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Val Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Leu Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1579
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v146 ECD

<400>  1579

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr Gln Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Lys Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Val Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1580
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v147 ECD

<400>  1580

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Arg 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Gly Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Ala Phe Pro Gln Gly Ser 
            100                 105                 110         


Trp Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1581
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v148 ECD

<400>  1581

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val His Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Ser Ser Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Ala Phe His Gln Thr Arg Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1582
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v149 ECD

<400>  1582

Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Pro Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Gln Gly Glu Ser Gly Ser Met Ala Val Tyr His Arg Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1583
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v150 ECD

<400>  1583

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Cys Ala Arg 
        35                  40                  45              


Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Thr Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Thr Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1584
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v151 ECD

<400>  1584

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Thr Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Gly Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Trp Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1585
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v152 ECD

<400>  1585

Trp Pro Pro Pro Gly Thr Gly Asp Val Phe Val Gln Ala Pro Ser Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Gln 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Met Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1586
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v153 ECD

<400>  1586

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Met Gly Asp Ser Val Thr Leu Pro Cys Phe Leu Gln 
            20                  25                  30          


Val Pro Asp Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Trp Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Gly Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1587
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v154 ECD

<400>  1587

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Val Ser Gly Gly Met Ala Val Phe His Arg Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly 
65                  70                  75                  80  


Ala Gly Leu Arg Asn Ala Thr Leu Arg Ile Ser Arg Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1588
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v155 ECD

<400>  1588

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr His 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1589
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v156 ECD

<400>  1589

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Gly Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Arg Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Leu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Ala Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1590
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v157 ECD

<400>  1590

Trp Pro Pro Pro Gly Thr Gly Gly Ile Val Ala Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Ala Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Leu Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Ala Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1591
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v158 ECD

<400>  1591

Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Glu Arg 
        35                  40                  45              


His Ser Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1592
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v159 ECD

<400>  1592

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Pro Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1593
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v160 ECD

<400>  1593

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Ser His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Pro Gly Arg Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1594
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v161 ECD

<400>  1594

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asn Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Asn Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1595
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v162 ECD

<400>  1595

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Ser Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Val Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1596
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v163 ECD

<400>  1596

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe Asn Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Ala Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Thr Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1597
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v164 ECD

<400>  1597

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Arg Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Asp Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Gly Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1598
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v165 ECD

<400>  1598

Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Lys Val Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Thr Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1599
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v166 ECD

<400>  1599

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Leu Ala Val Phe His Gln Arg Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Ile Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1600
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v167 ECD

<400>  1600

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ile Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Met Pro Phe Met Glu Val Ser His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Leu Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Ser Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1601
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v168 ECD

<400>  1601

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Glu Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Trp Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1602
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v169 ECD

<400>  1602

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Ile Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Val Arg 
        35                  40                  45              


His Gly Lys Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1603
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v170 ECD

<400>  1603

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Ala Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His His Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Val Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1604
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v171 ECD

<400>  1604

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Gly Ser Val Thr Leu Pro Arg Tyr Leu Gln 
            20                  25                  30          


Val Pro Asp Met Gly Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ala Tyr Gly Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Gly Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Arg Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1605
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v172 ECD

<400>  1605

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Glu Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Arg Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Thr Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1606
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v173 ECD

<400>  1606

Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1607
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v174 ECD

<400>  1607

Trp Pro Pro Pro Gly Thr Gly Asp Ala Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Ser Leu Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1608
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v175 ECD

<400>  1608

Trp Pro Pro Pro Gly Thr Gly Glu Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Ala Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1609
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v176 ECD

<400>  1609

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Ala Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Arg Gly Glu Ser Gly Cys Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Ser Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Tyr Ala Ser Pro Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1610
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v177 ECD

<400>  1610

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Glu Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val His Gly Tyr Leu Gly Asp Ser Glu Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Ser Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1611
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v178 ECD

<400>  1611

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Ala Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Asp 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Ala Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1612
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v179 ECD

<400>  1612

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Arg Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1613
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v180 ECD

<400>  1613

Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Met Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Ser Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Gly Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Met Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1614
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v181 ECD

<400>  1614

Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Tyr Gly Phe Leu Gly Asp Ser Ala Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Gly Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Val Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Thr Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Ile Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1615
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v182 ECD

<400>  1615

Trp Pro Pro Pro Gly Thr Gly Asp Val Gly Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Gln Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1616
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v183 ECD

<400>  1616

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe Arg Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Gly Ala Ser Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1617
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v184 ECD

<400>  1617

Trp Pro Pro Pro Gly Thr Gly Asp Ala Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Gly Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Arg Ile 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1618
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v185 ECD

<400>  1618

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ala Gly Ser Met Ala Ala Phe His Arg Thr Lys Gly Pro 
    50                  55                  60                  


Cys Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Thr Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Tyr Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1619
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v186 ECD

<400>  1619

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asp Met Glu Val Thr His Val Ser Gln Leu Thr Trp Glu Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Asp Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Asn Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1620
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v187 ECD

<400>  1620

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Ser Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Thr Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1621
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v188 ECD

<400>  1621

Trp Pro Pro Pro Gly Thr Gly Asp Asp Val Met Leu Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Val Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Ile Ala Val Phe His Arg Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Gln Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1622
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v189 ECD

<400>  1622

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ser Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys His Leu Leu 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  1623
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v144 IgV

<400>  1623

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Asp 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Asn Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Gln 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Tyr Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1624
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v145 IgV

<400>  1624

Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln Val Leu Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Val Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Leu Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Glu Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1625
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v146 IgV

<400>  1625

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr Gln Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Lys Lys Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Val Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1626
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v147 IgV

<400>  1626

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Arg Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Gly Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Ala Phe Pro Gln Gly Ser Trp Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1627
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v148 IgV

<400>  1627

Pro Gly Thr Gly Asp Val Val Val His Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Ser Ser Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Ala Phe His Gln Thr Arg Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1628
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v149 IgV

<400>  1628

Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Pro Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg Gln Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Tyr His Arg Thr Lys Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1629
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v150 IgV

<400>  1629

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Cys Ala Arg Arg Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Thr Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Thr Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1630
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v151 IgV

<400>  1630

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Thr Gln Leu Thr Trp Ala Arg His Gly Gly 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Trp Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1631
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v152 IgV

<400>  1631

Pro Gly Thr Gly Asp Val Phe Val Gln Ala Pro Ser Gln Val Leu Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Gln His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Met 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1632
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v153 IgV

<400>  1632

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Met Gly Asp Ser Val Thr Leu Pro Cys Phe Leu Gln Val Pro Asp 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Trp Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Gly Ile Trp Leu 
        115     


<210>  1633
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v154 IgV

<400>  1633

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Val 
        35                  40                  45              


Ser Gly Gly Met Ala Val Phe His Arg Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly Ala Gly Leu 
65                  70                  75                  80  


Arg Asn Ala Thr Leu Arg Ile Ser Arg Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1634
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v155 IgV

<400>  1634

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr His Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1635
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v156 IgV

<400>  1635

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Gly Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Arg Thr Gln Gly Pro Ser Tyr Leu 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Ala 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1636
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v157 IgV

<400>  1636

Pro Gly Thr Gly Gly Ile Val Ala Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Ala Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Leu Phe Pro Gln Gly Ser Arg Ser Ala 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1637
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v158 IgV

<400>  1637

Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Glu Arg His Ser Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1638
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v159 IgV

<400>  1638

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Pro Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1639
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v160 IgV

<400>  1639

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Ser His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Pro Gly Arg Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1640
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v161 IgV

<400>  1640

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asn Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Asn Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1641
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v162 IgV

<400>  1641

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Ser Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Val 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1642
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v163 IgV

<400>  1642

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe Asn Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Ala Ala Ala Arg Pro Gly Thr Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1643
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v164 IgV

<400>  1643

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Arg Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Asp Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Gly Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1644
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v165 IgV

<400>  1644

Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Lys Val Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Thr Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1645
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v166 IgV

<400>  1645

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Leu Ala Val Phe His Gln Arg Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Ile Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1646
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v167 IgV

<400>  1646

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ile Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Met Pro Phe 
            20                  25                  30          


Met Glu Val Ser His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Leu Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Ser Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1647
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v168 IgV

<400>  1647

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Glu Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Trp Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1648
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v169 IgV

<400>  1648

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Ile Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Val Arg His Gly Lys 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1649
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v170 IgV

<400>  1649

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Ala Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His His Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Val Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1650
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v171 IgV

<400>  1650

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Gly Ser Val Thr Leu Pro Arg Tyr Leu Gln Val Pro Asp 
            20                  25                  30          


Met Gly Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro Ala Tyr Gly 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Gly Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Met Phe Pro Arg Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1651
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v172 IgV

<400>  1651

Pro Gly Thr Gly Asp Val Val Val Gln Glu Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Arg Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Thr 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1652
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v173 IgV

<400>  1652

Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg Arg Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1653
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v174 IgV

<400>  1653

Pro Gly Thr Gly Asp Ala Val Val Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Ser Leu Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1654
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v175 IgV

<400>  1654

Pro Gly Thr Gly Glu Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Ala Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1655
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v176 IgV

<400>  1655

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Ala Ser Gln Leu Thr Trp Ala Arg Arg Gly Glu 
        35                  40                  45              


Ser Gly Cys Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Ser Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Tyr Ala Ser Pro Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1656
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v177 IgV

<400>  1656

Pro Gly Thr Gly Asp Val Val Glu Gln Ala Pro Thr Gln Val His Gly 
1               5                   10                  15      


Tyr Leu Gly Asp Ser Glu Thr Leu Pro Cys Tyr Leu Gln Val Pro Ser 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg Arg Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1657
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v178 IgV

<400>  1657

Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Ala Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Asp Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Ala Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1658
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v179 IgV

<400>  1658

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Arg Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1659
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v180 IgV

<400>  1659

Pro Gly Thr Gly Asp Leu Val Met Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Ser 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Gly Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser Arg Ser Met 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1660
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v181 IgV

<400>  1660

Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln Val Tyr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Ala Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Gly Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Val Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Thr Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Ile Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1661
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v182 IgV

<400>  1661

Pro Gly Thr Gly Asp Val Gly Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Gln Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1662
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v183 IgV

<400>  1662

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe Arg Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Gly Ala Ser Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1663
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v184 IgV

<400>  1663

Pro Gly Thr Gly Asp Ala Val Val Gln Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Gly Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Arg Ile Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1664
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v185 IgV

<400>  1664

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ala Gly Ser Met Ala Ala Phe His Arg Thr Lys Gly Pro Cys Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Thr Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Tyr Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1665
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v186 IgV

<400>  1665

Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln Val Phe Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asp 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Glu Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Asp 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Asn Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1666
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v187 IgV

<400>  1666

Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln Val Thr Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Ser 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Thr Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1667
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v188 IgV

<400>  1667

Pro Gly Thr Gly Asp Asp Val Met Leu Ala Pro Thr Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
            20                  25                  30          


Met Val Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Ile Ala Val Phe His Arg Thr Gln Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Gln Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1668
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v189 IgV

<400>  1668

Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ser Gln Val Ser Gly 
1               5                   10                  15      


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys His Leu Leu Val Pro Asn 
            20                  25                  30          


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
        35                  40                  45              


Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro Ser Tyr Ser 
    50                  55                  60                  


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu 
65                  70                  75                  80  


Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly 
                85                  90                  95      


Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val 
            100                 105                 110         


Asp Ile Trp Leu 
        115     


<210>  1669
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v144 IgV

<400>  1669

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Asp Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Asn Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Gln Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Tyr Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1670
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v145 IgV

<400>  1670

Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Val Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Leu Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1671
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v146 IgV

<400>  1671

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr Gln Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Lys Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Val Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1672
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v147 IgV

<400>  1672

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Arg 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Gly Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Ala Phe Pro Gln Gly Ser 
            100                 105                 110         


Trp Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1673
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v148 IgV

<400>  1673

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val His Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Ser Ser Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Ala Phe His Gln Thr Arg Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1674
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v149 IgV

<400>  1674

Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Pro Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Gln Gly Glu Ser Gly Ser Met Ala Val Tyr His Arg Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1675
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v150 IgV

<400>  1675

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Cys Ala Arg 
        35                  40                  45              


Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Thr Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Thr Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1676
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v151 IgV

<400>  1676

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Thr Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Gly Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Trp Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1677
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v152 IgV

<400>  1677

Trp Pro Pro Pro Gly Thr Gly Asp Val Phe Val Gln Ala Pro Ser Gln 
1               5                   10                  15      


Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Gln 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Met Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1678
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v153 IgV

<400>  1678

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Met Gly Asp Ser Val Thr Leu Pro Cys Phe Leu Gln 
            20                  25                  30          


Val Pro Asp Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Trp Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Gly Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1679
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v154 IgV

<400>  1679

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Val Ser Gly Gly Met Ala Val Phe His Arg Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly 
65                  70                  75                  80  


Ala Gly Leu Arg Asn Ala Thr Leu Arg Ile Ser Arg Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1680
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v155 IgV

<400>  1680

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr His 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1681
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v156 IgV

<400>  1681

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Gly Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Arg Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Leu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Ala Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1682
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v157 IgV

<400>  1682

Trp Pro Pro Pro Gly Thr Gly Gly Ile Val Ala Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Ala Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Leu Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Ala Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1683
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v158 IgV

<400>  1683

Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Glu Arg 
        35                  40                  45              


His Ser Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1684
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v159 IgV

<400>  1684

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Pro Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1685
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v160 IgV

<400>  1685

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Ser His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Pro Gly Arg Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1686
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v161 IgV

<400>  1686

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asn Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Asn Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1687
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v162 IgV

<400>  1687

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Ser Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Val Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1688
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v163 IgV

<400>  1688

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe Asn Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Ala Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Thr Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1689
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v164 IgV

<400>  1689

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Arg Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Asp Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Gly Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1690
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v165 IgV

<400>  1690

Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Lys Val Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Thr Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1691
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v166 IgV

<400>  1691

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Leu Ala Val Phe His Gln Arg Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Ile Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1692
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v167 IgV

<400>  1692

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ile Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Met Pro Phe Met Glu Val Ser His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Leu Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Ser Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1693
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v168 IgV

<400>  1693

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Glu Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Trp Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1694
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v169 IgV

<400>  1694

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Ile Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Val Arg 
        35                  40                  45              


His Gly Lys Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1695
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v170 IgV

<400>  1695

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Ala Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His His Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Val Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1696
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v171 IgV

<400>  1696

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Gly Ser Val Thr Leu Pro Arg Tyr Leu Gln 
            20                  25                  30          


Val Pro Asp Met Gly Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ala Tyr Gly Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Gly Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Arg Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1697
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v172 IgV

<400>  1697

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Glu Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Arg Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Thr Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1698
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v173 IgV

<400>  1698

Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1699
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v174 IgV

<400>  1699

Trp Pro Pro Pro Gly Thr Gly Asp Ala Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Ser Leu Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1700
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v175 IgV

<400>  1700

Trp Pro Pro Pro Gly Thr Gly Glu Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Ala Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1701
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v176 IgV

<400>  1701

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Ala Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Arg Gly Glu Ser Gly Cys Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Ser Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Tyr Ala Ser Pro Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1702
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v177 IgV

<400>  1702

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Glu Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val His Gly Tyr Leu Gly Asp Ser Glu Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Ser Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1703
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v178 IgV

<400>  1703

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Ala Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Asp 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Ala Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1704
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v179 IgV

<400>  1704

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Arg Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1705
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v180 IgV

<400>  1705

Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Met Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Ser Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Gly Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Met Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1706
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v181 IgV

<400>  1706

Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Tyr Gly Phe Leu Gly Asp Ser Ala Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Gly Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Val Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Thr Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Ile Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1707
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v182 IgV

<400>  1707

Trp Pro Pro Pro Gly Thr Gly Asp Val Gly Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Gln Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1708
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v183 IgV

<400>  1708

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe Arg Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Gly Ala Ser Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1709
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v184 IgV

<400>  1709

Trp Pro Pro Pro Gly Thr Gly Asp Ala Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Gly Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Arg Ile 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1710
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v185 IgV

<400>  1710

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ala Gly Ser Met Ala Ala Phe His Arg Thr Lys Gly Pro 
    50                  55                  60                  


Cys Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Thr Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Tyr Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1711
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v186 IgV

<400>  1711

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asp Met Glu Val Thr His Val Ser Gln Leu Thr Trp Glu Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Asp Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Asn Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1712
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v187 IgV

<400>  1712

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Ser Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Thr Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1713
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v188 IgV

<400>  1713

Trp Pro Pro Pro Gly Thr Gly Asp Asp Val Met Leu Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Val Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Ile Ala Val Phe His Arg Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Gln Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1714
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155 v189 IgV

<400>  1714

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ser Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys His Leu Leu 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
        115                 120         


<210>  1715
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stack Fc Lysine removed (homodimeric)

<400>  1715

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  1716
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1/CD155 Stack 1 Fc fusion

<400>  1716

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
    130                 135                 140                 


Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe 
145                 150                 155                 160 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                165                 170                 175     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            180                 185                 190         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        195                 200                 205             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    210                 215                 220                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
225                 230                 235                 240 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                245                 250                 255     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            260                 265                 270         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        275                 280                 285             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    290                 295                 300                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
305                 310                 315                 320 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                325                 330                 335     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            340                 345                 350         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val 
    370                 375                 380                 


Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
385                 390                 395                 400 


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
                405                 410                 415     


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
            420                 425                 430         


Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
        435                 440                 445             


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
    450                 455                 460                 


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
465                 470                 475                 480 


Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala 
                485                 490                 


<210>  1717
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1/CD155 Stack 2 Fc fusion

<400>  1717

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys 
        115                 120                 125             


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
    130                 135                 140                 


Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        195                 200                 205             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        355                 360                 365             


Gly Gly Gly Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
    370                 375                 380                 


Ala Pro Thr Gln Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
385                 390                 395                 400 


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
                405                 410                 415     


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
            420                 425                 430         


Thr Gln Gly Pro Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala 
        435                 440                 445             


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
    450                 455                 460                 


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe 
465                 470                 475                 480 


Pro Gln Arg Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
                485                 490                 


<210>  1718
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1/CD155 Stack 3 Fc fusion

<400>  1718

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val Pro Lys 
    130                 135                 140                 


Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys 
145                 150                 155                 160 


Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp 
                165                 170                 175     


Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu Glu Asp 
            180                 185                 190         


Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys 
        195                 200                 205             


Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys 
    210                 215                 220                 


Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly 
225                 230                 235                 240 


Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
305                 310                 315                 320 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 


<210>  1719
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1/CD155 Stack 4 Fc fusion

<400>  1719

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro 
    130                 135                 140                 


Thr Gln Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr 
145                 150                 155                 160 


Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp 
                165                 170                 175     


Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln 
            180                 185                 190         


Gly Pro Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg 
        195                 200                 205             


Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg 
    210                 215                 220                 


Val Glu Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln 
225                 230                 235                 240 


Arg Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
305                 310                 315                 320 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 


<210>  1720
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1/CD155 Stack 5 Fc fusion

<400>  1720

His Met Ser Ser Val Ser Ala Gln Glu Pro Lys Ser Ser Asp Lys Thr 
1               5                   10                  15      


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser 
            20                  25                  30          


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        35                  40                  45              


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    50                  55                  60                  


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
65                  70                  75                  80  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                85                  90                  95      


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            100                 105                 110         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        115                 120                 125             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    130                 135                 140                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
145                 150                 155                 160 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                165                 170                 175     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            180                 185                 190         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        195                 200                 205             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    210                 215                 220                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Trp 
                245                 250                 255     


Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val 
            260                 265                 270         


Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val 
        275                 280                 285             


Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His 
    290                 295                 300                 


Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Trp 
305                 310                 315                 320 


Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala 
                325                 330                 335     


Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp 
            340                 345                 350         


Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg 
        355                 360                 365             


Ser Val Asp Ile Trp Leu Arg Val Leu Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val Pro Lys Asp 
385                 390                 395                 400 


Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe 
                405                 410                 415     


Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu 
            420                 425                 430         


Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu Glu Asp Gln 
        435                 440                 445             


Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp 
    450                 455                 460                 


Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu 
465                 470                 475                 480 


Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala 
                485                 490                 495     


Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala 
            500                 505         


<210>  1721
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1/CD155 Stack 6 Fc fusion

<400>  1721

His Met Ser Ser Val Ser Ala Gln Glu Pro Lys Ser Ser Asp Lys Thr 
1               5                   10                  15      


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser 
            20                  25                  30          


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        35                  40                  45              


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    50                  55                  60                  


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
65                  70                  75                  80  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                85                  90                  95      


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            100                 105                 110         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        115                 120                 125             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    130                 135                 140                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
145                 150                 155                 160 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                165                 170                 175     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            180                 185                 190         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        195                 200                 205             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    210                 215                 220                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe 
                245                 250                 255     


Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn 
            260                 265                 270         


Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala 
        275                 280                 285             


Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe 
    290                 295                 300                 


Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln 
305                 310                 315                 320 


Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu 
                325                 330                 335     


Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met 
            340                 345                 350         


Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
        355                 360                 365             


Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr 
385                 390                 395                 400 


Gln Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu 
                405                 410                 415     


Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala 
            420                 425                 430         


Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly 
        435                 440                 445             


Pro Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu 
    450                 455                 460                 


Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val 
465                 470                 475                 480 


Glu Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg 
                485                 490                 495     


Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu 
            500                 505         


<210>  1722
<211>  635
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1/CD112/CD155 Stack 1 Fc fusion

<400>  1722

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro 
    130                 135                 140                 


Thr Gln Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr 
145                 150                 155                 160 


Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp 
                165                 170                 175     


Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln 
            180                 185                 190         


Gly Pro Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg 
        195                 200                 205             


Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg 
    210                 215                 220                 


Val Glu Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln 
225                 230                 235                 240 


Arg Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
305                 310                 315                 320 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Asp Val Arg 
            500                 505                 510         


Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly Thr Val Glu 
        515                 520                 525             


Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr Ile Ser Leu 
    530                 535                 540                 


Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln Asn Val Ala 
545                 550                 555                 560 


Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro Lys Pro Gly 
                565                 570                 575     


Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr Gly Gln Asp 
            580                 585                 590         


Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His Gly Leu Thr 
        595                 600                 605             


Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr Phe Pro Lys 
    610                 615                 620                 


Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val 
625                 630                 635 


<210>  1723
<211>  635
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1/CD112/CD155 Stack 2 Fc fusion

<400>  1723

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro 
    130                 135                 140                 


Thr Gln Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr 
145                 150                 155                 160 


Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp 
                165                 170                 175     


Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln 
            180                 185                 190         


Gly Pro Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg 
        195                 200                 205             


Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg 
    210                 215                 220                 


Val Glu Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln 
225                 230                 235                 240 


Arg Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Asp Val Arg Val Gln 
            260                 265                 270         


Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly Thr Val Glu Leu Pro 
        275                 280                 285             


Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr Ile Ser Leu Val Thr 
    290                 295                 300                 


Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln Asn Val Ala Ala Phe 
305                 310                 315                 320 


His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro Lys Pro Gly Ser Glu 
                325                 330                 335     


Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr Gly Gln Asp Thr Glu 
            340                 345                 350         


Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His Gly Leu Thr Val Glu 
        355                 360                 365             


Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr Phe Pro Lys Gly Phe 
    370                 375                 380                 


Val Arg Gly Met Thr Trp Leu Arg Val Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                405                 410                 415     


Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro 
            420                 425                 430         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        435                 440                 445             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    450                 455                 460                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
465                 470                 475                 480 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                485                 490                 495     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            500                 505                 510         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        515                 520                 525             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    530                 535                 540                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
545                 550                 555                 560 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                565                 570                 575     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            580                 585                 590         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        595                 600                 605             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    610                 615                 620                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630                 635 


<210>  1724
<211>  636
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1/CD112/CD155 Stack 3 Fc fusion

<400>  1724

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln 
    130                 135                 140                 


Leu Gly Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro 
145                 150                 155                 160 


Gly Leu Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala 
                165                 170                 175     


Asn His Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe 
            180                 185                 190         


Pro Ser Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys 
        195                 200                 205             


Gln Ser Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu 
    210                 215                 220                 


Ala Leu His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu 
225                 230                 235                 240 


Phe Ala Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg 
                245                 250                 255     


Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
        275                 280                 285             


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
    290                 295                 300                 


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
305                 310                 315                 320 


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
                325                 330                 335     


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
            340                 345                 350         


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
        355                 360                 365             


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
    370                 375                 380                 


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
                405                 410                 415     


Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe 
            420                 425                 430         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        435                 440                 445             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    450                 455                 460                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
465                 470                 475                 480 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                485                 490                 495     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            500                 505                 510         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        515                 520                 525             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    530                 535                 540                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
545                 550                 555                 560 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                565                 570                 575     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            580                 585                 590         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        595                 600                 605             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    610                 615                 620                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630                 635     


<210>  1725
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v66

<400>  1725

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp 
        115                 120                 125             


Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro 
    130                 135                 140                 


Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly 
145                 150                 155                 160 


Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val 
                165                 170                 175     


Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys 
            180                 185                 190         


Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val 
        195                 200                 205             


Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220     


<210>  1726
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV 66

<400>  1726

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105             


<210>  1727
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v66

<400>  1727

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala 
        115 


<210>  1728
<211>  221
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Wildtype PD-L1 ECD

<400>  1728

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1729
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v67

<400>  1729

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1730
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v68

<400>  1730

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Leu Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1731
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v69

<400>  1731

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Ser Arg Gly Leu Asp Pro Glu Lys Asn Gln Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1732
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v70

<400>  1732

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ser Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Gln 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Lys Asn Gln Thr Ala Glu Phe Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1733
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v71

<400>  1733

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Arg Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Leu Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Gln 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Asn Asn Gln Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Leu 
    210                 215                 220     


<210>  1734
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v72

<400>  1734

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Leu Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Phe Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1735
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v73

<400>  1735

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Ser Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Arg Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Ser Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1736
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v74

<400>  1736

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Val Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His His Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1737
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v75

<400>  1737

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Ile Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1738
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v76

<400>  1738

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1739
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v77

<400>  1739

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Thr Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Lys Asn Gln Thr Ala Glu Phe Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1740
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v78

<400>  1740

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Gln 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1741
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v79

<400>  1741

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1742
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v80

<400>  1742

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Val Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1743
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v81

<400>  1743

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1744
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v82

<400>  1744

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Gly Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1745
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v83

<400>  1745

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn Gln Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1746
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v84

<400>  1746

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1747
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v85

<400>  1747

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1748
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v86

<400>  1748

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1749
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v87

<400>  1749

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ser Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1750
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v88

<400>  1750

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Thr Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1751
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v89

<400>  1751

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Ala Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Leu Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1752
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v90

<400>  1752

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Ser Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Ser Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1753
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v91

<400>  1753

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Arg Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Ala 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Ala Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1754
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v92

<400>  1754

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Val Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Gly Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Glu Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1755
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v93

<400>  1755

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Thr Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1756
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v94

<400>  1756

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1757
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v95

<400>  1757

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1758
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v96

<400>  1758

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His His Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Ser Arg Arg Leu Asp Pro Glu Glu Tyr His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1759
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v97

<400>  1759

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1760
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v98

<400>  1760

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Pro Ser Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1761
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v99

<400>  1761

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Ile Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Gly Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Gly Glu Asn His Thr Ala Glu Leu Ala Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1762
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v100

<400>  1762

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Thr Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1763
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v101

<400>  1763

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Asn 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1764
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v102

<400>  1764

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1765
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v103

<400>  1765

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asp Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1766
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v104

<400>  1766

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1767
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v105

<400>  1767

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn Gln Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1768
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v106

<400>  1768

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1769
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v107

<400>  1769

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Ala Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1770
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v108

<400>  1770

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Glu Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1771
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v109

<400>  1771

Phe Thr Val Thr Val Pro Lys Asp Leu Phe Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Arg Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Ala Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1772
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v110

<400>  1772

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1773
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v111

<400>  1773

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Met 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1774
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v112

<400>  1774

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1775
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v113

<400>  1775

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1776
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v114

<400>  1776

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1777
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v115

<400>  1777

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1778
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v116

<400>  1778

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1779
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v117

<400>  1779

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Phe Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1780
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v118

<400>  1780

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Asp Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1781
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v119

<400>  1781

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1782
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v120

<400>  1782

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Thr Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Tyr Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Ser Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1783
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v121

<400>  1783

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Gly Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Pro Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1784
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v122

<400>  1784

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Ile Asn Val Thr 
                165                 170                 175     


Cys Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1785
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v123

<400>  1785

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1786
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v124

<400>  1786

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Thr Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1787
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v125

<400>  1787

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Tyr Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1788
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v126

<400>  1788

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Tyr Ser Lys Arg Glu Gly Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1789
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v127

<400>  1789

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Val Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1790
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v128

<400>  1790

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Phe Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1791
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v129

<400>  1791

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1792
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v131

<400>  1792

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Thr Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1793
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v131

<400>  1793

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Asp Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Ala Thr Thr Asn Glu Val Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1794
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v132

<400>  1794

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Tyr Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Ile Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Ser Asp Pro Glu Glu Asn His Ala Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1795
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v133

<400>  1795

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Asn Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Ser Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1796
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v134

<400>  1796

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Asp Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Trp Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1797
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v135

<400>  1797

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Val Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Leu Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1798
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v136

<400>  1798

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asp His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1799
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v137

<400>  1799

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Thr Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Ala Thr Thr Asn Glu Val Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1800
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v138

<400>  1800

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Ser Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1801
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v139

<400>  1801

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Arg Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Ala Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1802
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v140

<400>  1802

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Ile Thr Asn Ser Arg Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1803
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v141

<400>  1803

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Ala Thr Thr Asn Glu Ile Phe Tyr Cys Ser 
            180                 185                 190         


Phe Gly Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1804
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v142

<400>  1804

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Thr Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1805
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v143

<400>  1805

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Ala Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1806
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v144

<400>  1806

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Glu Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Ala Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1807
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v145

<400>  1807

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Ala Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Ile Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1808
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v146

<400>  1808

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Asn Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Thr Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1809
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v147

<400>  1809

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Asn Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Arg Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Ile Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1810
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v148

<400>  1810

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Arg Thr Ser Ser Asp His Gln Val Leu Gly Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1811
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v149

<400>  1811

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Arg Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Glu Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Val Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1812
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v150

<400>  1812

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Arg Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Asn Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Thr Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1813
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v151

<400>  1813

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1814
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v152

<400>  1814

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1815
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v153

<400>  1815

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Leu Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Leu Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Gly Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1816
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v154

<400>  1816

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asp His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1817
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v155

<400>  1817

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Glu Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asp His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1818
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v156

<400>  1818

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Pro Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1819
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v67

<400>  1819

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1820
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v68

<400>  1820

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Leu Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1821
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v69

<400>  1821

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Ser Arg Gly Leu Asp Pro Glu Lys Asn Gln Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1822
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v70

<400>  1822

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ser Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Gln 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Lys Asn Gln Thr Ala Glu Phe Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1823
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v72

<400>  1823

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Leu Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Phe Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1824
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v73

<400>  1824

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Ser Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Arg Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Ser Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1825
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v74

<400>  1825

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Val Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His His Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1826
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v75

<400>  1826

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Ile Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1827
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v76

<400>  1827

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1828
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v77

<400>  1828

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Thr Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Lys Asn Gln Thr Ala Glu Phe Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1829
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v78

<400>  1829

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Gln 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1830
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v79

<400>  1830

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1831
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v80

<400>  1831

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Val Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1832
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v81

<400>  1832

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1833
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v82

<400>  1833

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Gly Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1834
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v83

<400>  1834

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn Gln Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1835
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v84

<400>  1835

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1836
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v85

<400>  1836

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1837
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v86

<400>  1837

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1838
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v87

<400>  1838

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ser Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1839
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v88

<400>  1839

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Thr Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1840
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v89

<400>  1840

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Ala Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Leu Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1841
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v90

<400>  1841

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Ser Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Ser Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1842
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v91

<400>  1842

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Arg Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Ala 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Ala Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1843
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v92

<400>  1843

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Val Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Gly Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Glu Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1844
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v93

<400>  1844

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Thr Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1845
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v94

<400>  1845

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1846
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v95

<400>  1846

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1847
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v96

<400>  1847

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His His Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Ser Arg Arg Leu Asp Pro Glu Glu Tyr His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1848
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v97

<400>  1848

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1849
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v98

<400>  1849

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Pro Ser Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1850
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v99

<400>  1850

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Ile Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Gly Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Gly Glu Asn His Thr Ala Glu Leu Ala Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1851
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v100

<400>  1851

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Thr Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1852
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v101

<400>  1852

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Asn 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1853
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v102

<400>  1853

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1854
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v103

<400>  1854

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asp Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1855
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v104

<400>  1855

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1856
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v105

<400>  1856

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn Gln Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1857
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v106

<400>  1857

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1858
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v107

<400>  1858

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Ala Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1859
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v108

<400>  1859

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Glu Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1860
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v109

<400>  1860

Phe Thr Val Thr Val Pro Lys Asp Leu Phe Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Arg Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Ala Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1861
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v110

<400>  1861

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1862
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v111

<400>  1862

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Met 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1863
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v112

<400>  1863

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1864
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v113

<400>  1864

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1865
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v114

<400>  1865

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1866
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v115

<400>  1866

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1867
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v116

<400>  1867

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1868
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v117

<400>  1868

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Phe Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1869
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v118

<400>  1869

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Asp Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1870
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v119

<400>  1870

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1871
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v120

<400>  1871

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Thr Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Tyr Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Ser Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1872
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v121

<400>  1872

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Gly Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Pro Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1873
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v122

<400>  1873

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Ile Asn Val Thr 
                165                 170                 175     


Cys Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1874
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v123

<400>  1874

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1875
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v124

<400>  1875

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Thr Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1876
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v125

<400>  1876

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Tyr Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1877
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v126

<400>  1877

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Tyr Ser Lys Arg Glu Gly Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1878
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v127

<400>  1878

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Val Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1879
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v128

<400>  1879

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Phe Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1880
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v129

<400>  1880

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1881
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v131

<400>  1881

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Thr Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1882
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v131

<400>  1882

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Asp Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Ala Thr Thr Asn Glu Val Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1883
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v132

<400>  1883

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Tyr Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Ile Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Ser Asp Pro Glu Glu Asn His Ala Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1884
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v133

<400>  1884

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Asn Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Ser Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1885
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v134

<400>  1885

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Asp Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Trp Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1886
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v135

<400>  1886

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Val Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Leu Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1887
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v136

<400>  1887

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asp His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1888
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v137

<400>  1888

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Thr Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Ala Thr Thr Asn Glu Val Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1889
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v138

<400>  1889

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Ser Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1890
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v139

<400>  1890

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Arg Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Ala Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1891
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v140

<400>  1891

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Ile Thr Asn Ser Arg Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1892
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v141

<400>  1892

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Ala Thr Thr Asn Glu Ile Phe Tyr Cys Ser 
            180                 185                 190         


Phe Gly Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1893
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v142

<400>  1893

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Thr Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1894
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v143

<400>  1894

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Ala Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1895
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v144

<400>  1895

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Glu Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Ala Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1896
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v145

<400>  1896

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Ala Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Ile Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1897
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v146

<400>  1897

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Asn Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Thr Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1898
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v147

<400>  1898

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Asn Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Arg Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Ile Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1899
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v148

<400>  1899

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Arg Thr Ser Ser Asp His Gln Val Leu Gly Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1900
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v149

<400>  1900

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Arg Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Glu Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Val Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1901
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v150

<400>  1901

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Arg Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Asn Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Thr Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1902
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v151

<400>  1902

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1903
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v152

<400>  1903

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1904
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v153

<400>  1904

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Leu Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Leu Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Gly Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1905
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v154

<400>  1905

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asp His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1906
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v155

<400>  1906

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Glu Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asp His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1907
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v156

<400>  1907

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Pro Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  1908
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v67

<400>  1908

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Gly Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  1909
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v75

<400>  1909

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Ile Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Gly Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  1910
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v80

<400>  1910

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Val Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Gly Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  1911
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v81

<400>  1911

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Thr Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105         


<210>  1912
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v82

<400>  1912

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Gly Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Gly Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  1913
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v87

<400>  1913

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ser Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  1914
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v94

<400>  1914

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Thr Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105         


<210>  1915
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v98

<400>  1915

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Pro Ser Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105         


<210>  1916
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v100

<400>  1916

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Thr Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Thr Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105         


<210>  1917
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v102

<400>  1917

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Gly Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  1918
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v103

<400>  1918

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asp Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Gly Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  1919
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v110

<400>  1919

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  1920
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v118

<400>  1920

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Asp Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  1921
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v127

<400>  1921

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys Met Val Ser Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  1922
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v152

<400>  1922

Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
1               5                   10                  15      


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
            20                  25                  30          


Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
        35                  40                  45              


Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser Gln Arg Ala Arg Leu 
    50                  55                  60                  


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
65                  70                  75                  80  


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Gly Tyr Gly 
                85                  90                  95      


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105         


<210>  1923
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v67

<400>  1923

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  1924
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v75

<400>  1924

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Ile Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  1925
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v80

<400>  1925

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Val Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  1926
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v81

<400>  1926

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala 
        


<210>  1927
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v82

<400>  1927

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Gly Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  1928
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v87

<400>  1928

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ser Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  1929
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v94

<400>  1929

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala 
        


<210>  1930
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v98

<400>  1930

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Pro Ser Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala 
        


<210>  1931
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v100

<400>  1931

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Thr Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val 
            100                 105                 110         


Asn Ala 
        


<210>  1932
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v102

<400>  1932

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  1933
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v103

<400>  1933

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asp Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  1934
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v110

<400>  1934

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  1935
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v118

<400>  1935

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Asp Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  1936
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v127

<400>  1936

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Val Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  1937
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 IgV v152

<400>  1937

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala 
        


<210>  1938
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc (C5S (C220S), R77C, (R292C),  N82G (N297G), V87C (V302C), 
       L232del (K447del))

<400>  1938

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln 
65                  70                  75                  80  


Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  1939
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc with C220S/L234A/L235E/G237A/K447del

<400>  1939

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  1940
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc with C220S/E233P/L234V/L235A/G236del/S267K/K447del

<400>  1940

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Lys His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly 
225                 230 


<210>  1941
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  1941

Gly Ser Gly Gly Gly Gly Ser 
1               5           


<210>  1942
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4GS Linker

<400>  1942

Gly Gly Gly Gly Ser 
1               5   


<210>  1943
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v1

<400>  1943

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Asn Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val Asn Gly Glu Glu Asp Leu Glu Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1944
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v2

<400>  1944

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Thr Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1945
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v3

<400>  1945

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Glu Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1946
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v4

<400>  1946

Phe Thr Val Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Thr Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1947
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v5

<400>  1947

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1948
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v6

<400>  1948

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1949
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v7

<400>  1949

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1950
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v8

<400>  1950

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1951
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v9

<400>  1951

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1952
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v10

<400>  1952

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1953
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v11

<400>  1953

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1954
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v12

<400>  1954

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asp Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Gly Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1955
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v13

<400>  1955

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Ser Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1956
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v14

<400>  1956

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1957
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v15

<400>  1957

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1958
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v16

<400>  1958

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1959
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v17

<400>  1959

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1960
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v18

<400>  1960

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1961
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v19

<400>  1961

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Glu Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1962
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v20

<400>  1962

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Ile Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val Arg Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1963
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v21

<400>  1963

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Glu Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln Arg Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1964
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v22

<400>  1964

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1965
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v23

<400>  1965

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Gly 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Glu Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1966
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v24

<400>  1966

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1967
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v25

<400>  1967

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1968
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v26

<400>  1968

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Val Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1969
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v27

<400>  1969

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1970
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v28

<400>  1970

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Gly Met Glu Val Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1971
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v29

<400>  1971

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Ser Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1972
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v30

<400>  1972

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1973
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v31

<400>  1973

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1974
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v32

<400>  1974

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1975
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v33

<400>  1975

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1976
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v34

<400>  1976

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1977
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v35

<400>  1977

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1978
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v36

<400>  1978

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Met Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1979
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v37

<400>  1979

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1980
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v38

<400>  1980

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Pro Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1981
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v39

<400>  1981

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1982
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v40

<400>  1982

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Arg Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1983
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v41

<400>  1983

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1984
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v42

<400>  1984

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Val Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1985
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v43

<400>  1985

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Gly Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1986
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v44

<400>  1986

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1987
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v45

<400>  1987

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1988
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v46

<400>  1988

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1989
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v47

<400>  1989

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1990
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v48

<400>  1990

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1991
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v49

<400>  1991

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1992
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v50

<400>  1992

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1993
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v51

<400>  1993

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1994
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v52

<400>  1994

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Ala Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val Tyr Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1995
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v53

<400>  1995

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1996
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v54

<400>  1996

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1997
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v55

<400>  1997

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1998
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v56

<400>  1998

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Gly Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  1999
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v57

<400>  1999

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  2000
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v58

<400>  2000

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  2001
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v59

<400>  2001

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Gly Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Asp Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  2002
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v60

<400>  2002

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp 
        115                 120                 125             


Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro 
    130                 135                 140                 


Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly 
145                 150                 155                 160 


Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val 
                165                 170                 175     


Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys 
            180                 185                 190         


Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val 
        195                 200                 205             


Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220         


<210>  2003
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v61

<400>  2003

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  2004
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v62

<400>  2004

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  2005
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v63

<400>  2005

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Ile Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Ile Ile Ile Gln 
        35                  40                  45              


Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Lys Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  2006
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v64

<400>  2006

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  2007
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v65

<400>  2007

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220     


<210>  2008
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 ECD v66

<400>  2008

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp 
        115                 120                 125             


Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro 
    130                 135                 140                 


Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly 
145                 150                 155                 160 


Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val 
                165                 170                 175     


Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys 
            180                 185                 190         


Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val 
        195                 200                 205             


Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
    210                 215                 220         


<210>  2009
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Peptide

<400>  2009

Met Gly Ser Thr Ala Ile Leu Ala Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Ser Ala 
            


<210>  2010
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag

<400>  2010

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  2011
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  2011

His His His His His His 
1               5       


<210>  2012
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wildtype PD-L1 SIP

<400>  2012

Met Gly Ser Thr Ala Ile Leu Ala Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Ser Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu 
            20                  25                  30          


Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln 
        35                  40                  45              


Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn 
    50                  55                  60                  


Ile Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser 
65                  70                  75                  80  


Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly 
                85                  90                  95      


Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val 
            100                 105                 110         


Tyr Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr 
        115                 120                 125             


Val Lys Val Asn Ala 
    130             


<210>  2013
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 v60 SIP

<400>  2013

Met Gly Ser Thr Ala Ile Leu Ala Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Ser Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu 
            20                  25                  30          


Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln 
        35                  40                  45              


Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp 
    50                  55                  60                  


Ile Ile Gln Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser 
65                  70                  75                  80  


Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly 
                85                  90                  95      


Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val 
            100                 105                 110         


Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile 
        115                 120                 125             


Thr Val Lys Val Asn Ala 
    130                 


<210>  2014
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge and transmembrane domain

<400>  2014

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45              


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    50                  55                  60                  


Leu Val Ile Thr 
65              


<210>  2015
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antiCD19 chimeric antigen receptor CAR-2

<400>  2015

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
305                 310                 315                 320 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                325                 330                 335     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            340                 345                 350         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        355                 360                 365             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    370                 375                 380                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
385                 390                 395                 400 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                405                 410                 415     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430     


<210>  2016
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antiCD19 chimeric antigen receptor CAR-2

<400>  2016

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
    130                 135                 140                 


Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
145                 150                 155                 160 


Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro 
                165                 170                 175     


Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu 
            180                 185                 190         


Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala 
        195                 200                 205             


Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val 
    210                 215                 220                 


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            340                 345                 350         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        355                 360                 365             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    370                 375                 380                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                405                 410                 415     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            420                 425                 430         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        435                 440                 445             


Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
    450                 455                 460                 


Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Arg Ser Glu Leu Ile Lys 
465                 470                 475                 480 


Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn His 
                485                 490                 495     


His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr 
            500                 505                 510         


Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala 
        515                 520                 525             


Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe Ile 
    530                 535                 540                 


Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu 
545                 550                 555                 560 


Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val Leu 
                565                 570                 575     


Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn 
            580                 585                 590         


Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met Gln 
        595                 600                 605             


Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala 
    610                 615                 620                 


Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly 
625                 630                 635                 640 


Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys 
                645                 650                 655     


Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg 
            660                 665                 670         


Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His 
        675                 680                 685             


Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His 
    690                 695                 700                 


Lys Leu Asn 
705         


<210>  2017
<211>  8708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD19 chimeric antigen receptor CAR-2

<400>  2017
agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag       60

caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg      120

tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact      180

gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacaa taaacgggtc      240

tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct      300

taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga      360

ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg      420

cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact      480

cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa      540

attttgacta gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg      600

gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat      660

aaattaaaac atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc      720

ctgttagaaa catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag      780

acaggatcag aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat      840

caaaggatag agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac      900

aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat      960

gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg     1020

agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat     1080

aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat     1140

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt     1200

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca     1260

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat     1320

ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag     1380

taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat     1440

taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa     1500

gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat     1560

aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt     1620

aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt     1680

atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga     1740

agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat ctcgacggta     1800

tcggttaact tttaaaagaa aaggggggat tggggggtac agtgcagggg aaagaatagt     1860

agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta caaaaattca     1920

aaattttatc gatcacgaga ctagcctcga gaagcttgat atcgaattcc cacggggttg     1980

gacgcgtagg aacagagaaa caggagaata tgggccaaac aggatatctg tggtaagcag     2040

ttcctgcccc ggctcagggc caagaacagt tggaacagca gaatatgggc caaacaggat     2100

atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg     2160

gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc ccaaggacct     2220

gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg     2280

cgcttctgct ccccgagctc tatataagca gagctcgttt agtgaaccgt cagatcgcct     2340

ggagacgcca tccacgctgt tttgacttcc atagaaggat cccctgcagg taatacgact     2400

cactataggg tccactgccg ccaccatggc tctgcctgtg acagctctgc tgctgcctct     2460

ggccctgctg ctccatgccg ccagacccgg atccgatatc cagatgaccc agaccaccag     2520

cagcctgagc gccagcctgg gcgatagagt gaccatcagc tgcagagcca gccaggacat     2580

cagcaagtac ctgaactggt atcagcagaa acccgacggc accgtgaagc tgctgatcta     2640

ccacaccagc agactgcaca gcggcgtgcc cagcagattt tctggcagcg gctccggcac     2700

cgactacagc ctgaccatct ccaacctgga acaggaagat atcgctacct acttctgtca     2760

gcaaggcaac accctgccct acaccttcgg cggaggcacc aagctggaaa tcaccggcag     2820

cacaagcggc agcggcaagc ctggatctgg cgagggaagc accaagggcg aagtgaaact     2880

gcaggaaagc ggccctggac tggtggcccc aagccagtct ctgagcgtga cctgtaccgt     2940

gtccggcgtg tccctgcctg actatggcgt gtcctggatc agacagccac ccagaaaggg     3000

cctggaatgg ctgggagtga tctggggcag cgagacaacc tactacaaca gcgccctgaa     3060

gtcccggctg accatcatca aggacaactc caagagccag gtgttcctga agatgaacag     3120

cctgcagacc gacgacaccg ccatctacta ctgcgccaag cactactact acggcggcag     3180

ctacgccatg gactactggg gccagggcac aagcgtgacc gtgtccagcg ctagcgccaa     3240

gcccaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc     3300

cctgtccctg cgcccagagg cgagccggcc agcggcgggg ggcgcagtgc acacgagggg     3360

gctggacttc gccagtgata tctacatctg ggcgcccctg gccgggactt gtggggtcct     3420

tctcctgtca ctggttatca ccctttactg cagagtgaag ttcagcagga gcgcagacgc     3480

ccccgcgtac cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga     3540

ggagtacgat gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag     3600

aaggaagaac cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc     3660

ctacagtgag attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta     3720

ccagggtctc agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc     3780

ccctcgcggc agtggcgagg gcagaggaag tctgctaaca tgcggtgacg tggaggagaa     3840

tccgggcccc tctagaagcg agctgattaa ggagaacatg cacatgaagc tgtacatgga     3900

gggcaccgtg gacaaccatc acttcaagtg cacatccgag ggcgaaggca agccctacga     3960

gggcacccag accatgagaa tcaaggtggt cgagggcggc cctctcccct tcgccttcga     4020

catcctggct actagcttcc tctacggcag caagaccttc atcaaccaca cccagggcat     4080

ccccgacttc ttcaagcagt ccttccctga gggcttcaca tgggagagag tcaccacata     4140

cgaagacggg ggcgtgctga ccgctaccca ggacaccagc ctccaggacg gctgcctcat     4200

ctacaacgtc aagatcagag gggtgaactt cacatccaac ggccctgtga tgcagaagaa     4260

aacactcggc tgggaggcct tcaccgagac gctgtacccc gctgacggcg gcctggaagg     4320

cagaaacgac atggccctga agctcgtggg cgggagccat ctgatcgcaa acatcaagac     4380

cacatataga tccaagaaac ccgctaagaa cctcaagatg cctggcgtct actatgtgga     4440

ctacagactg gaaagaatca aggaggccaa caacgagacc tacgtcgagc agcacgaggt     4500

ggcagtggcc agatactgcg acctccctag caaactgggg cacaagctta attgagtcga     4560

caatcaacct ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc     4620

tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta ttgcttcccg     4680

tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt atgaggagtt     4740

gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg caacccccac     4800

tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt tccccctccc     4860

tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag gggctcggct     4920

gttgggcact gacaattccg tggtgttgtc ggggaagctg acgtcctttc catggctgct     4980

cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct     5040

caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc ttccgcgtct     5100

tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc ctggaattcg     5160

agctcggtac ctttaagacc aatgacttac aaggcagctg tagatcttag ccacttttta     5220

aaagaaaagg ggggactgga agggctaatt cactcccaac gaagacaaga tctgcttttt     5280

gcttgtactg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta     5340

gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc     5400

cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa     5460

atctctagca gtagtagttc atgtcatctt attattcagt atttataact tgcaaagaaa     5520

tgaatatcag agagtgagag gaacttgttt attgcagctt ataatggtta caaataaagc     5580

aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg     5640

tccaaactca tcaatgtatc ttatcatgtc tggctctagc tatcccgccc ctaactccgc     5700

ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat gcagaggccg     5760

aggccgcctc ggcctctgag ctattccaga agtagtgagg aggctttttt ggaggcctag     5820

gcttttgcgt cgagacgtac ccaattcgcc ctatagtgag tcgtattacg cgcgctcact     5880

ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct     5940

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc     6000

ttcccaacag ttgcgcagcc tgaatggcga atggcgcgac gcgccctgta gcggcgcatt     6060

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc     6120

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca     6180

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc     6240

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt     6300

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac     6360

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc     6420

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt     6480

aacgtttaca atttcccagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt     6540

ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg     6600

cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt     6660

cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta     6720

aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc     6780

ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa     6840

gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc     6900

cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt     6960

acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact     7020

gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac     7080

aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata     7140

ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta     7200

ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg     7260

gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat     7320

aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt     7380

aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga     7440

aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa     7500

gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag     7560

gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac     7620

tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc     7680

gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat     7740

caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat     7800

actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct     7860

acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt     7920

cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg     7980

gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta     8040

cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg     8100

gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg     8160

tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc     8220

tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg     8280

gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat     8340

aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc     8400

agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg     8460

cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa agcgggcagt     8520

gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc tttacacttt     8580

atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca cacaggaaac     8640

agctatgacc atgattacgc caagcgcgca attaaccctc actaaaggga acaaaagctg     8700

gagctgca                                                              8708


<210>  2018
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antiCD19 chimeric antigen receptor CAR-1

<400>  2018

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Arg Val Lys Phe 
305                 310                 315                 320 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                325                 330                 335     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            340                 345                 350         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        355                 360                 365             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    370                 375                 380                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
385                 390                 395                 400 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                405                 410                 415     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425             


<210>  2019
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antiCD19 chimeric antigen receptor CAR-1

<400>  2019

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    130                 135                 140                 


Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
                165                 170                 175     


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
            180                 185                 190         


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
        195                 200                 205             


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
    210                 215                 220                 


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
225                 230                 235                 240 


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Ala Lys 
            260                 265                 270         


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            340                 345                 350         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        355                 360                 365             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    370                 375                 380                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                405                 410                 415     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            420                 425                 430         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        435                 440                 445             


Pro Pro Arg Gly Gly Arg Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
    450                 455                 460                 


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Arg Ser Glu Leu Ile 
465                 470                 475                 480 


Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn 
                485                 490                 495     


His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly 
            500                 505                 510         


Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe 
        515                 520                 525             


Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe 
    530                 535                 540                 


Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro 
545                 550                 555                 560 


Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val 
                565                 570                 575     


Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr 
            580                 585                 590         


Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met 
        595                 600                 605             


Gln Lys Lys Thr Leu Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala 
    610                 615                 620                 


Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly 
625                 630                 635                 640 


Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys 
                645                 650                 655     


Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg 
            660                 665                 670         


Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His 
        675                 680                 685             


Glu Val Ala Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Lys 
    690                 695                 700                 


Leu Asn 
705     


<210>  2020
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Blue fluorescent protein

<400>  2020

Ser Arg Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met 
1               5                   10                  15      


Glu Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu 
            20                  25                  30          


Gly Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu 
        35                  40                  45              


Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu 
    50                  55                  60                  


Tyr Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe 
65                  70                  75                  80  


Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr 
                85                  90                  95      


Tyr Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln 
            100                 105                 110         


Asp Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr 
        115                 120                 125             


Ser Asn Gly Pro Val Met Gln Lys Lys Thr Leu Trp Glu Ala Phe Thr 
    130                 135                 140                 


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met 
145                 150                 155                 160 


Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr 
                165                 170                 175     


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
            180                 185                 190         


Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu 
        195                 200                 205             


Thr Tyr Val Glu Gln His Glu Val Ala Ala Arg Tyr Cys Asp Leu Pro 
    210                 215                 220                 


Ser Lys Leu Gly His Lys Leu Asn 
225                 230         


<210>  2021
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  2021

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  2022
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v1 ECD

<400>  2022

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2023
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v2 ECD

<400>  2023

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2024
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v3 ECD

<400>  2024

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2025
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v4 ECD

<400>  2025

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Tyr Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Leu Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Pro Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2026
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v5 ECD

<400>  2026

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2027
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v6 ECD

<400>  2027

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Cys Pro Arg Pro Asn Val Cys Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2028
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v7 ECD

<400>  2028

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2029
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v8 ECD

<400>  2029

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Asp Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Ala Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2030
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v9 ECD

<400>  2030

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Ala Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2031
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v10 ECD

<400>  2031

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Arg Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2032
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v11 ECD

<400>  2032

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Gly Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2033
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v12 ECD

<400>  2033

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Tyr Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2034
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v13 ECD

<400>  2034

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2035
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v14 ECD

<400>  2035

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2036
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v15 ECD

<400>  2036

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Gly Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Cys Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2037
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v16 ECD

<400>  2037

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Cys Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2038
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v17 ECD

<400>  2038

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2039
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v18 ECD

<400>  2039

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Tyr Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Cys Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2040
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v19 ECD

<400>  2040

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Tyr Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


Pro Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2041
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v20 ECD

<400>  2041

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Pro Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2042
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v21 ECD

<400>  2042

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Glu Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2043
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v22 ECD

<400>  2043

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ala Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2044
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v23 ECD

<400>  2044

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Pro Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2045
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v24 ECD

<400>  2045

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Lys Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Pro 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2046
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v25 ECD

<400>  2046

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val His Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2047
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v26 ECD

<400>  2047

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Ala Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2048
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v27 ECD

<400>  2048

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Thr Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2049
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v28 ECD

<400>  2049

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Pro 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2050
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v29 ECD

<400>  2050

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ser Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val His Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Ser Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2051
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v30 ECD

<400>  2051

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Gln Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Pro Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2052
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v31 ECD

<400>  2052

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Gly Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2053
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v32 ECD

<400>  2053

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser His Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2054
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v33 ECD

<400>  2054

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Asp Cys Phe 
                85                  90                  95      


Val Phe Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2055
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v34 ECD

<400>  2055

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Asp Cys Phe 
                85                  90                  95      


Val Phe Ser Arg Ser Leu Glu Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ser Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2056
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL WT IgV

<400>  2056

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2057
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v1 IgV

<400>  2057

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2058
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v2 IgV

<400>  2058

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2059
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v3 IgV

<400>  2059

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2060
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v4 IgV

<400>  2060

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Tyr Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2061
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v5 IgV

<400>  2061

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2062
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v10 IgV

<400>  2062

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Arg Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2063
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v11 IgV

<400>  2063

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Gly Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2064
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v12 IgV

<400>  2064

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Tyr Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2065
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v13 IgV

<400>  2065

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2066
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v14 IgV

<400>  2066

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2067
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v22 IgV

<400>  2067

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ala Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2068
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v23 IgV

<400>  2068

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Pro Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2069
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v24 IgV

<400>  2069

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Lys Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2070
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v28 IgV

<400>  2070

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Pro 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2071
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v30 IgV

<400>  2071

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Gln Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2072
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v33 IgV

<400>  2072

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Asp Cys Phe 
                85                  90                  95      


Val Phe Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2073
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v34 IgV

<400>  2073

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Asp Cys Phe 
                85                  90                  95      


Val Phe Ser Arg Ser Leu Glu Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2074
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v35 ECD

<400>  2074

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Glu Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2075
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v35 IgV

<400>  2075

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Glu Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2076
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v36 ECD

<400>  2076

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Leu Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2077
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v37 ECD

<400>  2077

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2078
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v38 ECD

<400>  2078

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Gln Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2079
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v39 ECD

<400>  2079

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2080
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v40 ECD

<400>  2080

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Gln Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2081
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v41 ECD

<400>  2081

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2082
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v42 ECD

<400>  2082

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Gly Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2083
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v43 ECD

<400>  2083

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Val Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Gly Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2084
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v44 ECD

<400>  2084

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2085
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v45 ECD

<400>  2085

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Ser Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Ser Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2086
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v46 ECD

<400>  2086

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Ala Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2087
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v47 ECD

<400>  2087

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2088
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v48 ECD

<400>  2088

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2089
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v49 ECD

<400>  2089

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ser Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2090
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v50 ECD

<400>  2090

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Ala Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2091
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v51 ECD

<400>  2091

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Arg Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2092
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v52 ECD

<400>  2092

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Thr Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Thr Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2093
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v53 ECD

<400>  2093

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Gly Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2094
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v54 ECD

<400>  2094

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr His His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Ala Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ser Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2095
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v55 ECD

<400>  2095

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Phe Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Thr Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2096
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v56 ECD

<400>  2096

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Val 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Cys Trp Ile Asn Met Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2097
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v57 ECD

<400>  2097

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Arg Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asn Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Phe Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Val Ile Gly Glu Gly Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2098
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v58 ECD

<400>  2098

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2099
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v59 ECD

<400>  2099

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Ala Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Met Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Gly 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2100
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v60 ECD

<400>  2100

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Ser Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Asn Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2101
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v61 ECD

<400>  2101

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Ile 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Asn Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Gln Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2102
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v62 ECD

<400>  2102

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Arg Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Leu His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Val Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Gly Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2103
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v63 ECD

<400>  2103

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Thr Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Cys Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Leu Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2104
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v64 ECD

<400>  2104

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Glu Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Ile 
                85                  90                  95      


Val Phe Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asp Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Ala Gly Ser Gln Thr Gly Asn Asp Thr Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2105
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v65 ECD

<400>  2105

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Ile 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Met Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2106
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v66 ECD

<400>  2106

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Ile 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ile Ser Val Pro Val Val Thr Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Arg Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Asn Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2107
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v67 ECD

<400>  2107

Asp Thr Gln Glu Lys Glu Val Arg Ala Val Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Arg Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Arg Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Ser Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Phe Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2108
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v68 ECD

<400>  2108

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Gly Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ser Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Lys Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2109
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v69 ECD

<400>  2109

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Pro Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Lys Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Gly Ile Gly Glu Lys Asp Lys Ile 
    210                 215                 220                 


Ser Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2110
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v70 ECD

<400>  2110

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Thr Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Ser Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2111
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v71 ECD

<400>  2111

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2112
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v72 ECD

<400>  2112

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Gly Arg Cys Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Lys Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Ser Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2113
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v73 ECD

<400>  2113

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Ala Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Ile Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2114
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v74 ECD

<400>  2114

Asp Thr Gln Glu Lys Glu Val Arg Ala Ile Val Gly Gly Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Gly Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Ala Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


Pro Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Val Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Met Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2115
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v75 ECD

<400>  2115

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Cys Phe Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asn Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ser Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2116
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v76 ECD

<400>  2116

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2117
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v77 ECD

<400>  2117

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asp 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2118
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v78 ECD

<400>  2118

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Leu 
                85                  90                  95      


Val Phe Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2119
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v79 ECD

<400>  2119

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Ala Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2120
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v80 ECD

<400>  2120

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Glu Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2121
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v81 ECD

<400>  2121

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ser Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Val Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Val 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2122
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v36 IgV

<400>  2122

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Leu Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2123
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v37  IgV

<400>  2123

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu 
            100                 105                 110     


<210>  2124
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v38  IgV

<400>  2124

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Gln Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu 
            100                 105                 110     


<210>  2125
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v39  IgV

<400>  2125

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2126
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v40  IgV

<400>  2126

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Gln Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu 
            100                 105                 110     


<210>  2127
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v41  IgV

<400>  2127

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2128
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v43  IgV

<400>  2128

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Val Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Gly Val Glu 
            100                 105                 110     


<210>  2129
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v44  IgV

<400>  2129

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2130
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v48 IgV

<400>  2130

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2131
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v50 IgV

<400>  2131

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Ala Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2132
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v51  IgV

<400>  2132

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Arg Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2133
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v60  IgV

<400>  2133

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Ser Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Asn Glu 
            100                 105                 110     


<210>  2134
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v78  IgV

<400>  2134

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Leu 
                85                  90                  95      


Val Phe Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2135
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v79 IgV

<400>  2135

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Ala Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2136
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v80  IgV

<400>  2136

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Glu Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2137
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v81 ECD

<400>  2137

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Gly Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2138
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v82 ECD

<400>  2138

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2139
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v83 ECD

<400>  2139

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asp Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2140
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v84 ECD

<400>  2140

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Arg Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2141
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v85 ECD

<400>  2141

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Pro Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2142
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v86 ECD

<400>  2142

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Pro Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asp Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2143
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v87 ECD

<400>  2143

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Val Thr 
            100                 105                 110         


Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro His 
        115                 120                 125             


Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn Gly 
    130                 135                 140                 


Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser Leu 
145                 150                 155                 160 


Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg Gly 
                165                 170                 175     


Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser Val 
            180                 185                 190         


Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu Thr 
        195                 200                 205             


Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile Thr 
    210                 215                 220                 


Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235         


<210>  2144
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v88 ECD

<400>  2144

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His Ile 
        35                  40                  45              


Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn Arg 
    50                  55                  60                  


Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu Arg 
65                  70                  75                  80  


Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu Val 
                85                  90                  95      


Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val Thr 
            100                 105                 110         


Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro His 
        115                 120                 125             


Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn Gly 
    130                 135                 140                 


Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser Leu 
145                 150                 155                 160 


Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg Gly 
                165                 170                 175     


Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser Val 
            180                 185                 190         


Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu Thr 
        195                 200                 205             


Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile Thr 
    210                 215                 220                 


Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235         


<210>  2145
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v89 ECD

<400>  2145

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Thr Ser Ile Asn Gly 
    130                 135                 140                 


Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser Leu 
145                 150                 155                 160 


Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg Gly 
                165                 170                 175     


Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser Val 
            180                 185                 190         


Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu Thr 
        195                 200                 205             


Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile Ala 
    210                 215                 220                 


Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235         


<210>  2146
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v90 ECD

<400>  2146

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Leu Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2147
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v91  ECD

<400>  2147

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Gln Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2148
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v92 ECD

<400>  2148

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Gln Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Gly 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2149
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v93 ECD

<400>  2149

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Gly Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2150
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v94 ECD

<400>  2150

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ser Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Lys Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2151
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v96 ECD

<400>  2151

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Thr Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Thr Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Ala Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2152
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v96 ECD

<400>  2152

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Ala Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Gln Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Gly Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2153
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v97 ECD

<400>  2153

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Phe Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Thr Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2154
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v98 ECD

<400>  2154

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Ile Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Phe Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Gly Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2155
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v85  IgV

<400>  2155

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Pro Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2156
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v86  IgV

<400>  2156

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Pro Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asp Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2157
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v87  IgV

<400>  2157

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
            100                 105                 110 


<210>  2158
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v88  IgV

<400>  2158

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His Ile 
        35                  40                  45              


Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn Arg 
    50                  55                  60                  


Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu Arg 
65                  70                  75                  80  


Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu Val 
                85                  90                  95      


Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110 


<210>  2159
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v91  IgV

<400>  2159

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Gln Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu 
            100                 105                 110     


<210>  2160
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v99 ECD

<400>  2160

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2161
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v100 ECD

<400>  2161

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2162
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v101 ECD

<400>  2162

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Gln Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2163
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v102 ECD

<400>  2163

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2164
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v103 ECD


<220>
<221>  VARIANT
<222>  (207)..(207)
<223>  X = N or Q

<400>  2164

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Xaa Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2165
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v104 ECD


<220>
<221>  VARIANT
<222>  (168)..(168)
<223>  X = N or Q

<220>
<221>  VARIANT
<222>  (207)..(207)
<223>  X = N or Q

<400>  2165

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Xaa Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Xaa Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2166
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v105 ECD

<400>  2166

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Gln Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2167
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v106 ECD

<400>  2167

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2168
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v107 ECD

<400>  2168

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Gln Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2169
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v108 ECD

<400>  2169

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Gln Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2170
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v109 ECD

<400>  2170

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2171
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v110 ECD


<220>
<221>  VARIANT
<222>  (155)..(155)
<223>  X = N or Q

<400>  2171

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Xaa Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2172
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v111 ECD

<400>  2172

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2173
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v112 ECD

<400>  2173

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2174
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v113 ECD

<400>  2174

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2175
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL V114 ECD

<400>  2175

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Gln Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2176
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v115 ECD

<400>  2176

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2177
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v116 ECD

<400>  2177

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Gln Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Gln Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2178
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v117 ECD

<400>  2178

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Gln Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2179
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v118 ECD

<400>  2179

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile His Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2180
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v119 ECD

<400>  2180

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Gln Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Gln Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2181
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v120 ECD

<400>  2181

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Gln Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Gln Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2182
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v121 ECD

<400>  2182

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Gln Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2183
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v122 ECD

<400>  2183

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2184
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v123 ECD

<400>  2184

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile His Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2185
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v124 ECD

<400>  2185

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Gln Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2186
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v125 ECD

<400>  2186

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Gln Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2187
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v126 ECD

<400>  2187

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2188
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v127 ECD


<220>
<221>  VARIANT
<222>  (168)..(168)
<223>  X = N or Q

<220>
<221>  VARIANT
<222>  (207)..(207)
<223>  X = N or Q

<400>  2188

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Xaa Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Xaa Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2189
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v128 ECD


<220>
<221>  VARIANT
<222>  (155)..(155)
<223>  X = N or Q

<220>
<221>  VARIANT
<222>  (168)..(168)
<223>  X = N or Q

<400>  2189

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Xaa Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Xaa Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2190
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v129 ECD

<400>  2190

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Gln Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2191
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v131 ECD

<400>  2191

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Gln Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Gln Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2192
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v131 ECD

<400>  2192

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Gln Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Gln Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2193
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v132 ECD

<400>  2193

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Gln Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2194
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v133 ECD

<400>  2194

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2195
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v134 ECD

<400>  2195

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Gln Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2196
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v135 ECD

<400>  2196

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Gln Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2197
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v136 ECD

<400>  2197

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Gln Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Gln Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Gln Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2198
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v99 IgV

<400>  2198

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2199
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v111 IgV

<400>  2199

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2200
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v137 ECD

<400>  2200

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2201
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v138 ECD

<400>  2201

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Leu Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Pro Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2202
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v139 ECD

<400>  2202

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Tyr Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Leu Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Pro Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2203
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v140 ECD

<400>  2203

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2204
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v141 ECD

<400>  2204

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Leu Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Pro Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2205
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v142 ECD

<400>  2205

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Leu Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2206
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v143 ECD

<400>  2206

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Pro Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2207
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v137 IgV

<400>  2207

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2208
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v144 ECD

<400>  2208

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2209
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v145 ECD

<400>  2209

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2210
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v146 ECD

<400>  2210

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2211
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v147 ECD

<400>  2211

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Val Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2212
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v148 ECD

<400>  2212

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Arg Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2213
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v149 ECD

<400>  2213

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Ala Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2214
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v150 ECD

<400>  2214

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asp Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2215
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v151 ECD

<400>  2215

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2216
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v152 ECD

<400>  2216

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2217
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v153 ECD

<400>  2217

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2218
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v154 ECD

<400>  2218

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2219
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v155 ECD

<400>  2219

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Val 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2220
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v156 ECD

<400>  2220

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2221
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v157 ECD

<400>  2221

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2222
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v158 ECD

<400>  2222

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Thr Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2223
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v159 ECD

<400>  2223

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2224
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v160 ECD

<400>  2224

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Tyr Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2225
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v161 ECD

<400>  2225

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Val 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2226
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v162 ECD

<400>  2226

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Val 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Cys Trp Ile Asn Met Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2227
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v163 ECD

<400>  2227

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Glu Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2228
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v164 ECD

<400>  2228

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Glu Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2229
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v165 ECD

<400>  2229

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Glu Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Ile Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2230
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v166 ECD

<400>  2230

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Glu Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2231
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v167 ECD

<400>  2231

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Glu Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asp Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2232
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v168 ECD

<400>  2232

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Ser Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Val Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2233
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v169 ECD

<400>  2233

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2234
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v170 ECD

<400>  2234

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2235
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v171 ECD

<400>  2235

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2236
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v172 ECD

<400>  2236

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2237
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v173 ECD

<400>  2237

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2238
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v174 ECD

<400>  2238

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2239
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v175 ECD

<400>  2239

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2240
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v176 ECD

<400>  2240

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2241
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v177 ECD


<220>
<221>  VARIANT
<222>  (115)..(115)
<223>  X is H or Q

<400>  2241

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Xaa Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2242
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v178 ECD

<400>  2242

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2243
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v179 ECD

<400>  2243

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Ser Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Arg Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2244
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  ICOSL WT IgV

<400>  2244

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2245
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v1 IgV

<400>  2245

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2246
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v2 IgV

<400>  2246

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2247
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v3 IgV

<400>  2247

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2248
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v5 IgV

<400>  2248

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2249
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v10 IgV

<400>  2249

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Arg Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2250
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v11 IgV

<400>  2250

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Gly Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2251
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v12 IgV

<400>  2251

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Tyr Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2252
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v13 IgV

<400>  2252

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2253
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v14 IgV

<400>  2253

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2254
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v21 IgV

<400>  2254

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Glu Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2255
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v22 IgV

<400>  2255

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ala Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2256
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v23 IgV

<400>  2256

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Pro Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2257
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v28 IgV

<400>  2257

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Pro 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2258
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v33 IgV

<400>  2258

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Asp Cys Phe 
                85                  90                  95      


Val Phe Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2259
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v34 IgV

<400>  2259

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Asp Cys Phe 
                85                  90                  95      


Val Phe Ser Arg Ser Leu Glu Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ser Ser Val 
        115                 120         


<210>  2260
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v35 IgV

<400>  2260

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Glu Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2261
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v36 IgV

<400>  2261

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Leu Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2262
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v37 IgV

<400>  2262

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2263
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v38 IgV

<400>  2263

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Gln Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2264
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v39 IgV

<400>  2264

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2265
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v40 IgV

<400>  2265

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Gln Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2266
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v41 IgV

<400>  2266

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2267
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v42 IgV

<400>  2267

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Gly Val 
        115                 120         


<210>  2268
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v43 IgV

<400>  2268

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Val Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Gly Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2269
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v44 IgV

<400>  2269

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2270
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v46 IgV

<400>  2270

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Ala 
        115                 120         


<210>  2271
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v48 IgV

<400>  2271

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2272
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v49 IgV

<400>  2272

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ser Ser Val 
        115                 120         


<210>  2273
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v50 IgV

<400>  2273

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Ala Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2274
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v51 IgV

<400>  2274

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Arg Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2275
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v52 IgV

<400>  2275

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Thr Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Thr Ala Asn Phe Ser Val 
        115                 120         


<210>  2276
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v54 IgV

<400>  2276

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr His His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Ala Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ser Ser Val 
        115                 120         


<210>  2277
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v60 IgV

<400>  2277

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Ser Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Asn Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2278
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v65 IgV

<400>  2278

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Ile 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Met 
        115                 120         


<210>  2279
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v78 IgV

<400>  2279

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Leu 
                85                  90                  95      


Val Phe Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2280
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v79 IgV

<400>  2280

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Ala Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2281
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v80 IgV

<400>  2281

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Glu Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2282
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v85 IgV

<400>  2282

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Pro Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2283
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v86 IgV

<400>  2283

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Pro Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asp Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2284
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v87 IgV

<400>  2284

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Val Thr 
            100                 105                 110         


Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120     


<210>  2285
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v88 IgV

<400>  2285

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His Ile 
        35                  40                  45              


Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn Arg 
    50                  55                  60                  


Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu Arg 
65                  70                  75                  80  


Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu Val 
                85                  90                  95      


Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val Thr 
            100                 105                 110         


Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120     


<210>  2286
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v91  IgV

<400>  2286

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Gln Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2287
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v99 IgV

<400>  2287

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2288
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v100 IgV

<400>  2288

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val 
        115                 120         


<210>  2289
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v111 IgV

<400>  2289

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2290
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v112 IgV

<400>  2290

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val 
        115                 120         


<210>  2291
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v113 IgV

<400>  2291

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val 
        115                 120         


<210>  2292
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v126 IgV

<400>  2292

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val 
        115                 120         


<210>  2293
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v137 IgV

<400>  2293

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2294
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v153 IgV

<400>  2294

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2295
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v154 IgV

<400>  2295

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2296
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v163 IgV

<400>  2296

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Glu Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2297
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v164 IgV

<400>  2297

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Glu Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2298
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v173 IgV

<400>  2298

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2299
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v180 ECD

<400>  2299

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ala Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2300
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v181 ECD

<400>  2300

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ala Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2301
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v182 ECD

<400>  2301

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ala Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2302
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v183 ECD

<400>  2302

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Ala Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2303
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v184 ECD

<400>  2303

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2304
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v185 ECD

<400>  2304

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gly Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2305
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v186 ECD

<400>  2305

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2306
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v187 ECD

<400>  2306

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Met Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2307
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v188 ECD

<400>  2307

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Met Ser Ser Leu Glu Trp Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2308
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v189 ECD

<400>  2308

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2309
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v190 ECD

<400>  2309

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Ser Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2310
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v191 ECD

<400>  2310

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2311
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v192 ECD

<400>  2311

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2312
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v193 ECD

<400>  2312

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2313
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v194 ECD

<400>  2313

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Ala Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2314
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v195 ECD

<400>  2314

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Glu Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2315
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v196 ECD

<400>  2315

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2316
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v197 ECD

<400>  2316

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Met Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2317
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v198 ECD

<400>  2317

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2318
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v199 ECD

<400>  2318

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Met Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2319
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v200 ECD

<400>  2319

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Val Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2320
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v201 ECD

<400>  2320

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Thr Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2321
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v202 ECD

<400>  2321

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Thr Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2322
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v203 ECD

<400>  2322

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Thr Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2323
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v204 ECD

<400>  2323

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Val Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2324
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v205 ECD

<400>  2324

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Lys Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2325
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v206 ECD

<400>  2325

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Lys Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2326
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v207 ECD

<400>  2326

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Leu Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2327
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v208 ECD

<400>  2327

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Asn Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2328
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v209 ECD

<400>  2328

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2329
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL V210 ECD

<400>  2329

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2330
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v211 ECD

<400>  2330

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Thr Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2331
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v212 ECD

<400>  2331

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Lys Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2332
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v213 ECD

<400>  2332

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2333
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v214 ECD

<400>  2333

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Trp Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Lys Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2334
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v215 ECD

<400>  2334

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Trp Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2335
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v216 ECD

<400>  2335

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2336
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v217 ECD

<400>  2336

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Cys Ser Ser Leu Glu Glu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2337
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v218 ECD

<400>  2337

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gly Ser Ser Leu Glu Pro Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Asp Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2338
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v219 ECD

<400>  2338

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gly Ser Ser Leu Glu Val Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gly Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2339
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v220 ECD

<400>  2339

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gly Ser Ser Leu Glu Val Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2340
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v221 ECD

<400>  2340

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Leu Ser Ser Leu Glu Val Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2341
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v222 ECD

<400>  2341

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Pro Ser Ser Leu Glu Pro Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2342
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v223 ECD

<400>  2342

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Pro Ser Ser Leu Glu Ser Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gly Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2343
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v224 ECD

<400>  2343

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gly Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2344
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v225 ECD

<400>  2344

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Thr Ser Ser Leu Glu Lys Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2345
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v226 ECD

<400>  2345

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Val Ser Ser Leu Glu Thr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Leu Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2346
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v227 ECD

<400>  2346

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Gln Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  2347
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v180 IgV

<400>  2347

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ala Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2348
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v181 IgV

<400>  2348

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ala Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2349
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v182 IgV

<400>  2349

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ala Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2350
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v183 IgV

<400>  2350

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Ala Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2351
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v184 IgV

<400>  2351

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2352
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v185 IgV

<400>  2352

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gly Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2353
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v186 IgV

<400>  2353

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2354
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v187 IgV

<400>  2354

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Met Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2355
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v188 IgV

<400>  2355

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Met Ser Ser Leu Glu Trp Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2356
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v189 IgV

<400>  2356

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2357
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v190 IgV

<400>  2357

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Ser Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2358
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v191 IgV

<400>  2358

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2359
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v192 IgV

<400>  2359

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2360
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v193 IgV

<400>  2360

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2361
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v194 IgV

<400>  2361

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Ala Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2362
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v195 IgV

<400>  2362

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Glu Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2363
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v196 IgV

<400>  2363

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2364
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v197 IgV

<400>  2364

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Met Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2365
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v198 IgV

<400>  2365

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2366
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v199 IgV

<400>  2366

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Met Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2367
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v200 IgV

<400>  2367

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Val Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2368
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v201 IgV

<400>  2368

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Thr Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2369
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v202 IgV

<400>  2369

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Thr Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2370
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v203 IgV

<400>  2370

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Thr Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2371
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v204 IgV

<400>  2371

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Val Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2372
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v205 IgV

<400>  2372

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Lys Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2373
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v206 IgV

<400>  2373

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Lys Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2374
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v207 IgV

<400>  2374

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Leu Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2375
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v208 IgV

<400>  2375

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Asn Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2376
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v209 IgV

<400>  2376

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2377
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v210 IgV

<400>  2377

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2378
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v211 IgV

<400>  2378

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Thr Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2379
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v212 IgV

<400>  2379

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Lys Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2380
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v213 IgV

<400>  2380

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2381
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v214 IgV

<400>  2381

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Trp Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Lys Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2382
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v215 IgV

<400>  2382

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Trp Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2383
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v216 IgV

<400>  2383

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2384
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v217 IgV

<400>  2384

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Cys Ser Ser Leu Glu Glu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2385
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v218 IgV

<400>  2385

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gly Ser Ser Leu Glu Pro Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Asp Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2386
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v219 IgV

<400>  2386

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gly Ser Ser Leu Glu Val Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gly Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2387
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v220 IgV

<400>  2387

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gly Ser Ser Leu Glu Val Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2388
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v221 IgV

<400>  2388

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Leu Ser Ser Leu Glu Val Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2389
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v222 IgV

<400>  2389

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Pro Ser Ser Leu Glu Pro Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2390
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v223 IgV

<400>  2390

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Pro Ser Ser Leu Glu Ser Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gly Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2391
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v224 IgV

<400>  2391

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gly Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2392
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v225 IgV

<400>  2392

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Thr Ser Ser Leu Glu Lys Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2393
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v226 IgV

<400>  2393

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Val Ser Ser Leu Glu Thr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Leu Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2394
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v227 IgV

<400>  2394

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Gln Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2395
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v180 IgV

<400>  2395

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ala Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2396
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v181 IgV

<400>  2396

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ala Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2397
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v182 IgV

<400>  2397

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ala Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2398
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v183 IgV

<400>  2398

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Ala Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2399
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v184 IgV

<400>  2399

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2400
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v185 IgV

<400>  2400

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gly Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2401
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v186 IgV

<400>  2401

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2402
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v187 IgV

<400>  2402

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Met Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2403
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v188 IgV

<400>  2403

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Met Ser Ser Leu Glu Trp Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2404
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v189 IgV

<400>  2404

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2405
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v190 IgV

<400>  2405

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Ser Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2406
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v191 IgV

<400>  2406

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2407
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v192 IgV

<400>  2407

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2408
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v193 IgV

<400>  2408

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2409
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v194 IgV

<400>  2409

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Ala Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2410
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v195 IgV

<400>  2410

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Glu Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2411
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v196 IgV

<400>  2411

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2412
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v197 IgV

<400>  2412

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Met Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2413
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v198 IgV

<400>  2413

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2414
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v199 IgV

<400>  2414

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Met Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2415
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v200 IgV

<400>  2415

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Val Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2416
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v201 IgV

<400>  2416

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Thr Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2417
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v202 IgV

<400>  2417

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Thr Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2418
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v203 IgV

<400>  2418

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Thr Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2419
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v204 IgV

<400>  2419

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Val Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ala Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2420
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v205 IgV

<400>  2420

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Lys Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2421
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v206 IgV

<400>  2421

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Lys Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2422
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v207 IgV

<400>  2422

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Leu Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2423
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v208 IgV

<400>  2423

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Asn Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2424
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v209 IgV

<400>  2424

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2425
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v210 IgV

<400>  2425

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2426
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v211 IgV

<400>  2426

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Phe Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Thr Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2427
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v212 IgV

<400>  2427

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Lys Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2428
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v213 IgV

<400>  2428

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2429
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v214 IgV

<400>  2429

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Trp Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Lys Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2430
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v215 IgV

<400>  2430

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Trp Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2431
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v216 IgV

<400>  2431

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Arg Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2432
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v217 IgV

<400>  2432

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Cys Ser Ser Leu Glu Glu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Ser Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2433
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v218 IgV

<400>  2433

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gly Ser Ser Leu Glu Pro Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Asp Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2434
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v219 IgV

<400>  2434

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gly Ser Ser Leu Glu Val Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gly Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2435
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v220 IgV

<400>  2435

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gly Ser Ser Leu Glu Val Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2436
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v221 IgV

<400>  2436

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Leu Ser Ser Leu Glu Val Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2437
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v222 IgV

<400>  2437

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Pro Ser Ser Leu Glu Pro Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2438
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v223 IgV

<400>  2438

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Pro Ser Ser Leu Glu Ser Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gly Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2439
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v224 IgV

<400>  2439

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Leu Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gly Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2440
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v225 IgV

<400>  2440

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Thr Ser Ser Leu Glu Lys Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2441
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v226 IgV

<400>  2441

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Val Ser Ser Leu Glu Thr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Leu Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2442
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v227 IgV

<400>  2442

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Gln Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2443
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v4 IgV

<400>  2443

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Tyr Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2444
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v4 IgV

<400>  2444

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Tyr Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2445
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v21 IgV

<400>  2445

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2446
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v24 IgV

<400>  2446

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Lys Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2447
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v24 IgV

<400>  2447

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Lys Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2448
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v30 IgV

<400>  2448

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Gln Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2449
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v30 IgV

<400>  2449

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Gln Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2450
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v34 IgV

<400>  2450

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Asp Cys Phe 
                85                  90                  95      


Val Phe Ser Arg Ser Leu Glu Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2451
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v96 IgV

<400>  2451

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Ala Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Gln Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Gly Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu 
            100                 105                 110     


<210>  2452
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v45 IgV

<400>  2452

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Ser Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu 
            100                 105                 110     


<210>  2453
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v45 IgV

<400>  2453

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Ser Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2454
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v52 IgV

<400>  2454

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Thr Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2455
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v54 IgV

<400>  2455

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr His His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Ala Leu Ser Val Glu 
            100                 105                 110     


<210>  2456
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v56 IgV

<400>  2456

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Val 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu 
            100                 105                 110     


<210>  2457
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v56 IgV

<400>  2457

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Val 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2458
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v57 IgV

<400>  2458

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Arg Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asn Glu 
            100                 105                 110     


<210>  2459
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v57 IgV

<400>  2459

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Arg Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asn Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2460
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v59 IgV

<400>  2460

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu 
            100                 105                 110     


<210>  2461
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v59 IgV

<400>  2461

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Ala Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2462
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v61 IgV

<400>  2462

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Ile 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Asn Val Glu 
            100                 105                 110     


<210>  2463
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v61 IgV

<400>  2463

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Ile 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Asn Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2464
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v62 IgV

<400>  2464

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Arg Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Leu His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2465
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v62 IgV

<400>  2465

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Arg Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Leu His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2466
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v63 IgV

<400>  2466

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Thr Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2467
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v63 IgV

<400>  2467

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Thr Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2468
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v64 IgV

<400>  2468

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Glu Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Ile 
                85                  90                  95      


Val Phe Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2469
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v64 IgV

<400>  2469

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Glu Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Ile 
                85                  90                  95      


Val Phe Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2470
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v65 IgV

<400>  2470

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Ile 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2471
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v66 IgV

<400>  2471

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Ile 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2472
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v66 IgV

<400>  2472

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe Glu Cys Ile 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ile Ser Val 
        115                 120         


<210>  2473
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v67 IgV

<400>  2473

Asp Thr Gln Glu Lys Glu Val Arg Ala Val Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Arg Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2474
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v67 IgV

<400>  2474

Asp Thr Gln Glu Lys Glu Val Arg Ala Val Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Arg Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2475
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v68 IgV

<400>  2475

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Gly Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2476
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v68 IgV

<400>  2476

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Gly Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ser Ser Val 
        115                 120         


<210>  2477
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v69 IgV

<400>  2477

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Pro Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Lys Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2478
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v69 IgV

<400>  2478

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Pro Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Lys Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2479
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v70 IgV

<400>  2479

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Thr Ala Asn Phe Ser Val 
        115                 120         


<210>  2480
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v72 IgV

<400>  2480

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Gly Arg Cys Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu 
            100                 105                 110     


<210>  2481
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v72 IgV

<400>  2481

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Gly Arg Cys Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2482
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v73 IgV

<400>  2482

Asp Thr Gln Glu Lys Glu Val Arg Ala Ile Val Gly Gly Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Gly Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Ala Glu 
            100                 105                 110     


<210>  2483
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v73 IgV

<400>  2483

Asp Thr Gln Glu Lys Glu Val Arg Ala Ile Val Gly Gly Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Gly Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Ala Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2484
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v74 IgV

<400>  2484

Asp Thr Gln Glu Lys Glu Val Arg Ala Ile Val Gly Gly Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Gly Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Ala Glu 
            100                 105                 110     


<210>  2485
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v74 IgV

<400>  2485

Asp Thr Gln Glu Lys Glu Val Arg Ala Ile Val Gly Gly Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Gly Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Ala Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2486
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v75 IgV

<400>  2486

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Cys Phe Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asn Glu 
            100                 105                 110     


<210>  2487
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v75 IgV

<400>  2487

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Cys Phe Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asn Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Ser Ser Val 
        115                 120         


<210>  2488
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v76 IgV

<400>  2488

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2489
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v81 IgV

<400>  2489

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu 
            100                 105                 110     


<210>  2490
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v81 IgV

<400>  2490

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2491
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v84 IgV

<400>  2491

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Arg Gly Phe Gln Glu Val Leu Ser Asp Glu 
            100                 105                 110     


<210>  2492
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v84 IgV

<400>  2492

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Arg Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2493
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v92 IgV

<400>  2493

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Gln Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu 
            100                 105                 110     


<210>  2494
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v92 IgV

<400>  2494

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Gln Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2495
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v96 IgV

<400>  2495

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Ala Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Gln Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Gly Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2496
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v98 IgV

<400>  2496

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Ile Leu Ser Asp Glu 
            100                 105                 110     


<210>  2497
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v98 IgV

<400>  2497

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Ile Leu Ser Asp Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2498
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v103 IgV

<400>  2498

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2499
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v103 IgV

<400>  2499

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2500
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v126 IgV

<400>  2500

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2501
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v106 IgV

<400>  2501

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2502
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v127 IgV

<400>  2502

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2503
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v108 IgV

<400>  2503

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val 
        115                 120         


<210>  2504
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v129 IgV

<400>  2504

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Gln Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Gln Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Gln Phe Ser Val 
        115                 120         


<210>  2505
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v140 IgV

<400>  2505

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2506
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v140 IgV

<400>  2506

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2507
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v142 IgV

<400>  2507

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2508
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v142 IgV

<400>  2508

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2509
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v177 IgV


<220>
<221>  VARIANT
<222>  (115)..(115)
<223>  x is H or Q

<400>  2509

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Xaa Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2510
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v148 IgV

<400>  2510

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Arg Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2511
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v148 IgV

<400>  2511

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Arg Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2512
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v149 IgV

<400>  2512

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Ala 
        115                 120         


<210>  2513
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v158 IgV

<400>  2513

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2514
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v169 IgV

<400>  2514

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2515
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v160 IgV

<400>  2515

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Tyr Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2516
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v160 IgV

<400>  2516

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Tyr Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  2517
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v164 IgV

<400>  2517

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asp Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Glu Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  2518
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL v168 IgV

<400>  2518

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu Arg Val Ala Ala Asn Ser Ser Val 
        115                 120         


<210>  2519
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 ECD

<400>  2519

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln 
        115                 120                 125         


<210>  2520
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 ECD

<400>  2520

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp Gln 
        115                 120                 125         


<210>  2521
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL16

<400>  2521

Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr 
1               5                   10                  15      


Ala Glu Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly 
            20                  25                  30          


Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys 
        35                  40                  45              


Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser 
    50                  55                  60                  


Glu Thr Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala 
65                  70                  75                  80  


Met Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu 
                85                  90                  95      


Pro Asp Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser 
            100                 105                 110         


Lys Glu Thr Thr Ala Ala Gly Asp Ser 
        115                 120     


<210>  2522
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3

<400>  2522

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
225                 230                 235                 240 


Arg Gly Gly Gly Asp Pro 
                245     


<210>  2523
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  2523

Gly Ser Gly Gly Ser 
1               5   


<210>  2524
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  2524

Gly Gly Gly Gly Ser Ser Ala 
1               5           


<210>  2525
<211>  1182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA-4 2519 - Fc

<400>  2525
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctaagg cgatgcacgt agcccagccc gctgttgttc tcgcaagttc tcgcggcata      120

gcctccttcg tatgtgagta tgccagtcca ggtaagtaca cggaggtacg ggtaactgta      180

ctgcggcagg ccgattccca ggttacggag gtttgtgcgg caacctacat gatgggtaac      240

gagcttacat ttctcgacga ctcaatatgt actgggacct cctcaggaaa tcaggtcaat      300

ctgaccatcc aaggtctgag ggcgatggat acgggtcttt atatttgcaa ggttgaactc      360

atgtatccgc ctccatacta tgaaggcatt ggaaatggaa cacaaatcta tgttattgac      420

ccggagccgt gtccagatag tgatcagggg ggaggtggat ccgagcccaa aagctccgac      480

aagactcaca catgcccccc ttgtccagcg cctgaagctg agggtgcgcc ctctgtcttc      540

cttttccccc ctaagccgaa agataccctg atgatctccc gcactcccga agtcacatgt      600

gttgttgtcg acgtatctca tgaagatcct gaggtgaaat tcaactggta tgtagacggg      660

gtcgaagttc ataatgctaa gactaagcca cgagaagagc aatacaactc aacgtatcgg      720

gtggtgagcg ttctgacggt tctgcaccaa gattggctta atggaaaaga gtataagtgc      780

aaggtgtcca acaaggctct tccggcaccc atcgaaaaga cgatttccaa agcgaaaggc      840

caacctaggg aaccgcaagt ttacactttg cccccgtgca gagaagaaat gaccaagaat      900

caagtttccc tgtggtgcct tgtgaagggc ttctacccta gcgatatagc agttgagtgg      960

gaatctaacg gccagcccga aaataattat aagactactc cgcccgtgct ggacagtgat     1020

ggttcatttt tcctgtattc aaaactcact gtggacaaat ctagatggca gcagggtaat     1080

gtgttctctt gttcagttat gcacgaggca ttgcacaatc actatacgca aaaaagtttg     1140

tctctctctc cgggggatta caaggatgac gacgataagt ag                        1182


<210>  2526
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 2519 - Fc

<400>  2526

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
    130                 135                 140                 


Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe 
145                 150                 155                 160 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                165                 170                 175     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            180                 185                 190         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        195                 200                 205             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    210                 215                 220                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
225                 230                 235                 240 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                245                 250                 255     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
            260                 265                 270         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
        275                 280                 285             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    290                 295                 300                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
305                 310                 315                 320 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                325                 330                 335     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            340                 345                 350         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Asp Tyr Lys Asp Asp 
        355                 360                 365             


Asp Asp Lys 
    370     


<210>  2527
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - Fc

<400>  2527
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttat tcacagtgac tgttccgaaa gagttgtata taatcgagca agggagtaat      120

gttaccctgg aatgcaattt tgacaccggg tcacacgtca acctcggagc gattactgct      180

tctttgcaaa aagttgaaaa cgacgcgtcc ccccataggg aaagggcgac ccttctggag      240

gagcagttgc cccttggcag ggcactcttt cacattcccc aggtgcaagt cagggacgag      300

gggcaatacc gctgcatcat aatttacggg gacgcgtggg actacaagta cttgactctc      360

aaagttaaag ctggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcagag      420

cccaaaagct ccgacaagac tcacacatgc cccccttgtc cagcgcctga agctgagggt      480

gcgccctctg tcttcctttt cccccctaag ccgaaagata ccctgatgat ctcccgcact      540

cccgaagtca catgtgttgt tgtcgacgta tctcatgaag atcctgaggt gaaattcaac      600

tggtatgtag acggggtcga agttcataat gctaagacta agccacgaga agagcaatac      660

aactcaacgt atcgggtggt gagcgttctg acggttctgc accaagattg gcttaatgga      720

aaagagtata agtgcaaggt gtccaacaag gctcttccgg cacccatcga aaagacgatt      780

tccaaagcga aaggccaacc tagggaaccg caagtttgca ctttgccccc gtcaagagaa      840

gaaatgacca agaatcaagt ttccctgtct tgcgcagtga agggcttcta ccctagcgat      900

atagcagttg agtgggaatc taacggccag cccgaaaata attataagac tactccgccc      960

gtgctggaca gtgatggttc atttttcctg gtttcaaaac tcactgtgga caaatctaga     1020

tggcagcagg gtaatgtgtt ctcttgttca gttatgcacg aggcattgca caatcactat     1080

acgcaaaaaa gtttgtctct ctctccgggg caccatcatc accatcacta g              1131


<210>  2528
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - Fc

<400>  2528

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
        115                 120                 125             


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
    130                 135                 140                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
145                 150                 155                 160 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                165                 170                 175     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            180                 185                 190         


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
        195                 200                 205             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    210                 215                 220                 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
225                 230                 235                 240 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser 
                245                 250                 255     


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
            260                 265                 270         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        275                 280                 285             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    290                 295                 300                 


Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
305                 310                 315                 320 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                325                 330                 335     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly His His His His 
            340                 345                 350         


His His 
        


<210>  2529
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 scFv - PD-L1 303- PD-L1 303- PD-L1 303-Fc

<400>  2529

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
225                 230                 235                 240 


Arg Gly Gly Gly Asp Pro Gly Gly Gly Gly Ser Ser Ala Phe Thr Val 
                245                 250                 255     


Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr 
            260                 265                 270         


Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu 
        275                 280                 285             


Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His 
    290                 295                 300                 


Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala 
305                 310                 315                 320 


Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile 
                325                 330                 335     


Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser 
            340                 345                 350         


Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val Pro 
    370                 375                 380                 


Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys 
385                 390                 395                 400 


Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr 
                405                 410                 415     


Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu Glu 
            420                 425                 430         


Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu 
        435                 440                 445             


Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val 
    450                 455                 460                 


Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly 
465                 470                 475                 480 


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val Pro Lys Asp Leu 
            500                 505                 510         


Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro 
        515                 520                 525             


Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met 
    530                 535                 540                 


Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu Glu Asp Gln Lys 
545                 550                 555                 560 


Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln 
                565                 570                 575     


Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln 
            580                 585                 590         


Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala Asp 
        595                 600                 605             


Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
625                 630                 635                 640 


Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe 
                645                 650                 655     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            660                 665                 670         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        675                 680                 685             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    690                 695                 700                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
705                 710                 715                 720 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                725                 730                 735     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            740                 745                 750         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        755                 760                 765             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    770                 775                 780                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
785                 790                 795                 800 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                805                 810                 815     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            820                 825                 830         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        835                 840                 845             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    850                 855                 860 


<210>  2530
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL16 - PD-L1 303 - PD-L1 303 - PD-L1 303 - Fc

<400>  2530

Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr 
1               5                   10                  15      


Ala Glu Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly 
            20                  25                  30          


Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys 
        35                  40                  45              


Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser 
    50                  55                  60                  


Glu Thr Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala 
65                  70                  75                  80  


Met Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu 
                85                  90                  95      


Pro Asp Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser 
            100                 105                 110         


Lys Glu Thr Thr Ala Ala Gly Asp Ser Gly Gly Gly Gly Ser Ser Ala 
        115                 120                 125             


Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
    130                 135                 140                 


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
145                 150                 155                 160 


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
                165                 170                 175     


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
            180                 185                 190         


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
        195                 200                 205             


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
    210                 215                 220                 


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
225                 230                 235                 240 


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val 
                245                 250                 255     


Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr 
            260                 265                 270         


Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu 
        275                 280                 285             


Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His 
    290                 295                 300                 


Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala 
305                 310                 315                 320 


Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile 
                325                 330                 335     


Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser 
            340                 345                 350         


Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val Pro 
    370                 375                 380                 


Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys 
385                 390                 395                 400 


Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr 
                405                 410                 415     


Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu Glu 
            420                 425                 430         


Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu 
        435                 440                 445             


Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val 
    450                 455                 460                 


Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly 
465                 470                 475                 480 


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            500                 505                 510         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 
        515                 520                 525             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    530                 535                 540                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
545                 550                 555                 560 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                565                 570                 575     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            580                 585                 590         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        595                 600                 605             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    610                 615                 620                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
625                 630                 635                 640 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                645                 650                 655     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            660                 665                 670         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        675                 680                 685             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    690                 695                 700                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
705                 710                 715                 720 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                725                 730                 735 


<210>  2531
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 2519 - PD-L1 303 - PD-L1 303 - PD-L1 303 - Fc

<400>  2531

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln Gly 
        115                 120                 125             


Gly Gly Gly Ser Ser Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr 
    130                 135                 140                 


Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val 
145                 150                 155                 160 


Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu 
                165                 170                 175     


Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu Glu Asp Gln Lys Ala 
            180                 185                 190         


Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu 
        195                 200                 205             


Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp 
    210                 215                 220                 


Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr 
225                 230                 235                 240 


Lys Arg Ile Thr Val Lys Val Asn Ala Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu 
            260                 265                 270         


Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln 
        275                 280                 285             


Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp 
    290                 295                 300                 


Ile Ile Gln Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser 
305                 310                 315                 320 


Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly 
                325                 330                 335     


Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val 
            340                 345                 350         


Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile 
        355                 360                 365             


Thr Val Lys Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
385                 390                 395                 400 


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
                405                 410                 415     


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
            420                 425                 430         


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
        435                 440                 445             


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
    450                 455                 460                 


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
465                 470                 475                 480 


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
                485                 490                 495     


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys 
            500                 505                 510         


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
        515                 520                 525             


Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    530                 535                 540                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
545                 550                 555                 560 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                565                 570                 575     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            580                 585                 590         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        595                 600                 605             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    610                 615                 620                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
625                 630                 635                 640 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                645                 650                 655     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            660                 665                 670         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        675                 680                 685             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    690                 695                 700                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
705                 710                 715                 720 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                725                 730                 735     


Leu Ser Pro Gly Lys 
            740     


<210>  2532
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA-4 2520 - PD-L1 303 - Fc

<400>  2532
aaggcgatgc acgtagccca gcccgctgtt gttctcgcaa gttctcgcgg catagcctcc       60

ttcgtatgtg agtatgccag tccaggtaag tacacggagg tacgggtaac tgtactgcgg      120

caggccgatt cccaggttac ggaggtttgt gcggcaacct acatgatggg taacgagctt      180

acatttctcg acgactcaat atgtactggg acctcctcag gaaatcaggt caatctgacc      240

atccaaggtc tgagggcgat ggatacgggt ctttatattt gcaaggttga actcatgtat      300

ccgcctccat actatgaagg cattggaaat ggaacacaaa tctatgttat tgacccggag      360

ccgtctccag atagtgatca gggatccgga gggtctgggg gaggcggttc tgggggtgga      420

ggctcattta ccgtaacggt ccctaaggat ttgtacgtgg ttgagtacgg gagcaatatg      480

acgattgaat gcaagttccc cgtagagaag cagctcgatt tggccgcttt gatagtgtac      540

tgggaaatgg aaggaaaaga catcattcaa ttcgtccacg gtgaagagga tcaaaaagcg      600

caacatagct cctatagaca acgcgcacgc ttgcttaaag accagctgag tcttggtaac      660

gcggcgctgc agattaccga cgtaaaactt caagacgcgg gagtttatcg ctgcatgatt      720

tcctacgggg gtggcgcaga ctataaaagg atcactgtaa aggtaaacgc cggtggaggt      780

gggtca                                                                 786


<210>  2533
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 2520 - PD-L1 303 - Fc

<400>  2533

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp Gln Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr 
    130                 135                 140                 


Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met 
145                 150                 155                 160 


Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala 
                165                 170                 175     


Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val 
            180                 185                 190         


His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg 
        195                 200                 205             


Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln 
    210                 215                 220                 


Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile 
225                 230                 235                 240 


Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn 
                245                 250                 255     


Ala Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys 
            260                 265                 270         


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
        275                 280                 285             


Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly 
            500 


<210>  2534
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA-4 2520 - PD-L2 1417 - Fc

<400>  2534
aaggcgatgc acgtagccca gcccgctgtt gttctcgcaa gttctcgcgg catagcctcc       60

ttcgtatgtg agtatgccag tccaggtaag tacacggagg tacgggtaac tgtactgcgg      120

caggccgatt cccaggttac ggaggtttgt gcggcaacct acatgatggg taacgagctt      180

acatttctcg acgactcaat atgtactggg acctcctcag gaaatcaggt caatctgacc      240

atccaaggtc tgagggcgat ggatacgggt ctttatattt gcaaggttga actcatgtat      300

ccgcctccat actatgaagg cattggaaat ggaacacaaa tctatgttat tgacccggag      360

ccgtctccag atagtgatca gggatccgga gggtctgggg gaggcggttc tgggggtgga      420

ggctcattat tcacagtgac tgttccgaaa gagttgtata taatcgagca agggagtaat      480

gttaccctgg aatgcaattt tgacaccggg tcacacgtca acctcggagc gattactgct      540

tctttgcaaa aagttgaaaa cgacgcgtcc ccccataggg aaagggcgac ccttctggag      600

gagcagttgc cccttggcag ggcactcttt cacattcccc aggtgcaagt cagggacgag      660

gggcaatacc gctgcatcat aatttacggg gacgcgtggg actacaagta cttgactctc      720

aaagttaaag ctggtggagg tgggtca                                          747


<210>  2535
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 2520 - PD-L2 1417 - Fc

<400>  2535

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp Gln Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Phe 
    130                 135                 140                 


Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser Asn 
145                 150                 155                 160 


Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu Gly 
                165                 170                 175     


Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro His 
            180                 185                 190         


Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Arg Ala 
        195                 200                 205             


Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr Arg 
    210                 215                 220                 


Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr Leu 
225                 230                 235                 240 


Lys Val Lys Ala Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            260                 265                 270         


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        275                 280                 285             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
305                 310                 315                 320 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                325                 330                 335     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            340                 345                 350         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    370                 375                 380                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
385                 390                 395                 400 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                405                 410                 415     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            420                 425                 430         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        435                 440                 445             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    450                 455                 460                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
465                 470                 475                 480 


Ser Leu Ser Leu Ser Pro Gly 
                485         


<210>  2536
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - CTLA-4 2519 - Fc

<400>  2536

Thr Thr Thr Ala Cys Cys Gly Thr Ala Ala Cys Gly Gly Thr Cys Cys 
1               5                   10                  15      


Cys Thr Ala Ala Gly Gly Ala Thr Thr Thr Gly Thr Ala Cys Gly Thr 
            20                  25                  30          


Gly Gly Thr Thr Gly Ala Gly Thr Ala Cys Gly Gly Gly Ala Gly Cys 
        35                  40                  45              


Ala Ala Thr Ala Thr Gly Ala Cys Gly Ala Thr Thr Gly Ala Ala Thr 
    50                  55                  60                  


Gly Cys Ala Ala Gly Thr Thr Cys Cys Cys Cys Gly Thr Ala Gly Ala 
65                  70                  75                  80  


Gly Ala Ala Gly Cys Ala Gly Cys Thr Cys Gly Ala Thr Thr Thr Gly 
                85                  90                  95      


Gly Cys Cys Gly Cys Thr Thr Thr Gly Ala Thr Ala Gly Thr Gly Thr 
            100                 105                 110         


Ala Cys Thr Gly Gly Gly Ala Ala Ala Thr Gly Gly Ala Ala Gly Gly 
        115                 120                 125             


Ala Ala Ala Ala Gly Ala Cys Ala Thr Cys Ala Thr Thr Cys Ala Ala 
    130                 135                 140                 


Thr Thr Cys Gly Thr Cys Cys Ala Cys Gly Gly Thr Gly Ala Ala Gly 
145                 150                 155                 160 


Ala Gly Gly Ala Thr Cys Ala Ala Ala Ala Ala Gly Cys Gly Cys Ala 
                165                 170                 175     


Ala Cys Ala Thr Ala Gly Cys Thr Cys Cys Thr Ala Thr Ala Gly Ala 
            180                 185                 190         


Cys Ala Ala Cys Gly Cys Gly Cys Ala Cys Gly Cys Thr Thr Gly Cys 
        195                 200                 205             


Thr Thr Ala Ala Ala Gly Ala Cys Cys Ala Gly Cys Thr Gly Ala Gly 
    210                 215                 220                 


Thr Cys Thr Thr Gly Gly Thr Ala Ala Cys Gly Cys Gly Gly Cys Gly 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Gly Ala Thr Thr Ala Cys Cys Gly Ala Cys Gly 
                245                 250                 255     


Thr Ala Ala Ala Ala Cys Thr Thr Cys Ala Ala Gly Ala Cys Gly Cys 
            260                 265                 270         


Gly Gly Gly Ala Gly Thr Thr Thr Ala Thr Cys Gly Cys Thr Gly Cys 
        275                 280                 285             


Ala Thr Gly Ala Thr Thr Thr Cys Cys Thr Ala Cys Gly Gly Gly Gly 
    290                 295                 300                 


Gly Thr Gly Gly Cys Gly Cys Ala Gly Ala Cys Thr Ala Thr Ala Ala 
305                 310                 315                 320 


Ala Ala Gly Gly Ala Thr Cys Ala Cys Thr Gly Thr Ala Ala Ala Gly 
                325                 330                 335     


Gly Thr Ala Ala Ala Cys Gly Cys Cys Gly Gly Ala Thr Cys Cys Gly 
            340                 345                 350         


Gly Ala Gly Gly Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly 
        355                 360                 365             


Cys Gly Gly Thr Thr Cys Thr Gly Gly Gly Gly Gly Thr Gly Gly Ala 
    370                 375                 380                 


Gly Gly Cys Thr Cys Ala Ala Ala Gly Gly Cys Gly Ala Thr Gly Cys 
385                 390                 395                 400 


Ala Cys Gly Thr Ala Gly Cys Cys Cys Ala Gly Cys Cys Cys Gly Cys 
                405                 410                 415     


Thr Gly Thr Thr Gly Thr Thr Cys Thr Cys Gly Cys Ala Ala Gly Thr 
            420                 425                 430         


Thr Cys Thr Cys Gly Cys Gly Gly Cys Ala Thr Ala Gly Cys Cys Thr 
        435                 440                 445             


Cys Cys Thr Thr Cys Gly Thr Ala Thr Gly Thr Gly Ala Gly Thr Ala 
    450                 455                 460                 


Thr Gly Cys Cys Ala Gly Thr Cys Cys Ala Gly Gly Thr Ala Ala Gly 
465                 470                 475                 480 


Thr Ala Cys Ala Cys Gly Gly Ala Gly Gly Thr Ala Cys Gly Gly Gly 
                485                 490                 495     


Thr Ala Ala Cys Thr Gly Thr Ala Cys Thr Gly Cys Gly Gly Cys Ala 
            500                 505                 510         


Gly Gly Cys Cys Gly Ala Thr Thr Cys Cys Cys Ala Gly Gly Thr Thr 
        515                 520                 525             


Ala Cys Gly Gly Ala Gly Gly Thr Thr Thr Gly Thr Gly Cys Gly Gly 
    530                 535                 540                 


Cys Ala Ala Cys Cys Thr Ala Cys Ala Thr Gly Ala Thr Gly Gly Gly 
545                 550                 555                 560 


Thr Ala Ala Cys Gly Ala Gly Cys Thr Thr Ala Cys Ala Thr Thr Thr 
                565                 570                 575     


Cys Thr Cys Gly Ala Cys Gly Ala Cys Thr Cys Ala Ala Thr Ala Thr 
            580                 585                 590         


Gly Thr Ala Cys Thr Gly Gly Gly Ala Cys Cys Thr Cys Cys Thr Cys 
        595                 600                 605             


Ala Gly Gly Ala Ala Ala Thr Cys Ala Gly Gly Thr Cys Ala Ala Thr 
    610                 615                 620                 


Cys Thr Gly Ala Cys Cys Ala Thr Cys Cys Ala Ala Gly Gly Thr Cys 
625                 630                 635                 640 


Thr Gly Ala Gly Gly Gly Cys Gly Ala Thr Gly Gly Ala Thr Ala Cys 
                645                 650                 655     


Gly Gly Gly Thr Cys Thr Thr Thr Ala Thr Ala Thr Thr Thr Gly Cys 
            660                 665                 670         


Ala Ala Gly Gly Thr Thr Gly Ala Ala Cys Thr Cys Ala Thr Gly Thr 
        675                 680                 685             


Ala Thr Cys Cys Gly Cys Cys Thr Cys Cys Ala Thr Ala Cys Thr Ala 
    690                 695                 700                 


Thr Gly Ala Ala Gly Gly Cys Ala Thr Thr Gly Gly Ala Ala Ala Thr 
705                 710                 715                 720 


Gly Gly Ala Ala Cys Ala Cys Ala Ala Ala Thr Cys Thr Ala Thr Gly 
                725                 730                 735     


Thr Thr Ala Thr Thr Gly Ala Cys Cys Cys Gly Gly Ala Gly Cys Cys 
            740                 745                 750         


Gly Thr Gly Thr Cys Cys Ala Gly Ala Thr Ala Gly Thr Gly Ala Thr 
        755                 760                 765             


Cys Ala Gly Gly Gly Thr Gly Gly Ala Gly Gly Thr Gly Gly Gly Thr 
    770                 775                 780                 


Cys Ala 
785     


<210>  2537
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - CTLA-4 2519 - Fc

<400>  2537

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser 
    130                 135                 140                 


Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys 
145                 150                 155                 160 


Tyr Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val 
                165                 170                 175     


Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe 
            180                 185                 190         


Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn 
        195                 200                 205             


Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys 
    210                 215                 220                 


Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn 
225                 230                 235                 240 


Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
                245                 250                 255     


Gln Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys 
            260                 265                 270         


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
        275                 280                 285             


Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly 
            500 


<210>  2538
<211>  747
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - CTLA-4 2519 - Fc

<400>  2538

Thr Thr Ala Thr Thr Cys Ala Cys Ala Gly Thr Gly Ala Cys Thr Gly 
1               5                   10                  15      


Thr Thr Cys Cys Gly Ala Ala Ala Gly Ala Gly Thr Thr Gly Thr Ala 
            20                  25                  30          


Thr Ala Thr Ala Ala Thr Cys Gly Ala Gly Cys Ala Ala Gly Gly Gly 
        35                  40                  45              


Ala Gly Thr Ala Ala Thr Gly Thr Thr Ala Cys Cys Cys Thr Gly Gly 
    50                  55                  60                  


Ala Ala Thr Gly Cys Ala Ala Thr Thr Thr Thr Gly Ala Cys Ala Cys 
65                  70                  75                  80  


Cys Gly Gly Gly Thr Cys Ala Cys Ala Cys Gly Thr Cys Ala Ala Cys 
                85                  90                  95      


Cys Thr Cys Gly Gly Ala Gly Cys Gly Ala Thr Thr Ala Cys Thr Gly 
            100                 105                 110         


Cys Thr Thr Cys Thr Thr Thr Gly Cys Ala Ala Ala Ala Ala Gly Thr 
        115                 120                 125             


Thr Gly Ala Ala Ala Ala Cys Gly Ala Cys Gly Cys Gly Thr Cys Cys 
    130                 135                 140                 


Cys Cys Cys Cys Ala Thr Ala Gly Gly Gly Ala Ala Ala Gly Gly Gly 
145                 150                 155                 160 


Cys Gly Ala Cys Cys Cys Thr Thr Cys Thr Gly Gly Ala Gly Gly Ala 
                165                 170                 175     


Gly Cys Ala Gly Thr Thr Gly Cys Cys Cys Cys Thr Thr Gly Gly Cys 
            180                 185                 190         


Ala Gly Gly Gly Cys Ala Cys Thr Cys Thr Thr Thr Cys Ala Cys Ala 
        195                 200                 205             


Thr Thr Cys Cys Cys Cys Ala Gly Gly Thr Gly Cys Ala Ala Gly Thr 
    210                 215                 220                 


Cys Ala Gly Gly Gly Ala Cys Gly Ala Gly Gly Gly Gly Cys Ala Ala 
225                 230                 235                 240 


Thr Ala Cys Cys Gly Cys Thr Gly Cys Ala Thr Cys Ala Thr Ala Ala 
                245                 250                 255     


Thr Thr Thr Ala Cys Gly Gly Gly Gly Ala Cys Gly Cys Gly Thr Gly 
            260                 265                 270         


Gly Gly Ala Cys Thr Ala Cys Ala Ala Gly Thr Ala Cys Thr Thr Gly 
        275                 280                 285             


Ala Cys Thr Cys Thr Cys Ala Ala Ala Gly Thr Thr Ala Ala Ala Gly 
    290                 295                 300                 


Cys Thr Gly Gly Ala Thr Cys Cys Gly Gly Ala Gly Gly Gly Thr Cys 
305                 310                 315                 320 


Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Gly Gly Thr Thr Cys Thr 
                325                 330                 335     


Gly Gly Gly Gly Gly Thr Gly Gly Ala Gly Gly Cys Thr Cys Ala Ala 
            340                 345                 350         


Ala Gly Gly Cys Gly Ala Thr Gly Cys Ala Cys Gly Thr Ala Gly Cys 
        355                 360                 365             


Cys Cys Ala Gly Cys Cys Cys Gly Cys Thr Gly Thr Thr Gly Thr Thr 
    370                 375                 380                 


Cys Thr Cys Gly Cys Ala Ala Gly Thr Thr Cys Thr Cys Gly Cys Gly 
385                 390                 395                 400 


Gly Cys Ala Thr Ala Gly Cys Cys Thr Cys Cys Thr Thr Cys Gly Thr 
                405                 410                 415     


Ala Thr Gly Thr Gly Ala Gly Thr Ala Thr Gly Cys Cys Ala Gly Thr 
            420                 425                 430         


Cys Cys Ala Gly Gly Thr Ala Ala Gly Thr Ala Cys Ala Cys Gly Gly 
        435                 440                 445             


Ala Gly Gly Thr Ala Cys Gly Gly Gly Thr Ala Ala Cys Thr Gly Thr 
    450                 455                 460                 


Ala Cys Thr Gly Cys Gly Gly Cys Ala Gly Gly Cys Cys Gly Ala Thr 
465                 470                 475                 480 


Thr Cys Cys Cys Ala Gly Gly Thr Thr Ala Cys Gly Gly Ala Gly Gly 
                485                 490                 495     


Thr Thr Thr Gly Thr Gly Cys Gly Gly Cys Ala Ala Cys Cys Thr Ala 
            500                 505                 510         


Cys Ala Thr Gly Ala Thr Gly Gly Gly Thr Ala Ala Cys Gly Ala Gly 
        515                 520                 525             


Cys Thr Thr Ala Cys Ala Thr Thr Thr Cys Thr Cys Gly Ala Cys Gly 
    530                 535                 540                 


Ala Cys Thr Cys Ala Ala Thr Ala Thr Gly Thr Ala Cys Thr Gly Gly 
545                 550                 555                 560 


Gly Ala Cys Cys Thr Cys Cys Thr Cys Ala Gly Gly Ala Ala Ala Thr 
                565                 570                 575     


Cys Ala Gly Gly Thr Cys Ala Ala Thr Cys Thr Gly Ala Cys Cys Ala 
            580                 585                 590         


Thr Cys Cys Ala Ala Gly Gly Thr Cys Thr Gly Ala Gly Gly Gly Cys 
        595                 600                 605             


Gly Ala Thr Gly Gly Ala Thr Ala Cys Gly Gly Gly Thr Cys Thr Thr 
    610                 615                 620                 


Thr Ala Thr Ala Thr Thr Thr Gly Cys Ala Ala Gly Gly Thr Thr Gly 
625                 630                 635                 640 


Ala Ala Cys Thr Cys Ala Thr Gly Thr Ala Thr Cys Cys Gly Cys Cys 
                645                 650                 655     


Thr Cys Cys Ala Thr Ala Cys Thr Ala Thr Gly Ala Ala Gly Gly Cys 
            660                 665                 670         


Ala Thr Thr Gly Gly Ala Ala Ala Thr Gly Gly Ala Ala Cys Ala Cys 
        675                 680                 685             


Ala Ala Ala Thr Cys Thr Ala Thr Gly Thr Thr Ala Thr Thr Gly Ala 
    690                 695                 700                 


Cys Cys Cys Gly Gly Ala Gly Cys Cys Gly Thr Gly Thr Cys Cys Ala 
705                 710                 715                 720 


Gly Ala Thr Ala Gly Thr Gly Ala Thr Cys Ala Gly Gly Gly Thr Gly 
                725                 730                 735     


Gly Ala Gly Gly Thr Gly Gly Gly Thr Cys Ala 
            740                 745         


<210>  2539
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - CTLA-4 2519 - Fc

<400>  2539

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val 
        115                 120                 125             


Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser 
    130                 135                 140                 


Pro Gly Lys Tyr Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp 
145                 150                 155                 160 


Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu 
                165                 170                 175     


Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn 
            180                 185                 190         


Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu 
        195                 200                 205             


Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly 
    210                 215                 220                 


Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro 
225                 230                 235                 240 


Asp Ser Asp Gln Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            260                 265                 270         


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        275                 280                 285             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
305                 310                 315                 320 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                325                 330                 335     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            340                 345                 350         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    370                 375                 380                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
385                 390                 395                 400 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                405                 410                 415     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            420                 425                 430         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        435                 440                 445             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    450                 455                 460                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
465                 470                 475                 480 


Ser Leu Ser Leu Ser Pro Gly 
                485         


<210>  2540
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - Fc - CTLA-4 2520

<400>  2540
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggatc cggagggtct      360

gggggaggcg gttctgagcc caaaagctcc gacaagactc acacatgccc cccttgtcca      420

gcgcctgaag ctgagggtgc gccctctgtc ttccttttcc cccctaagcc gaaagatacc      480

ctgatgatct cccgcactcc cgaagtcaca tgtgttgttg tcgacgtatc tcatgaagat      540

cctgaggtga aattcaactg gtatgtagac ggggtcgaag ttcataatgc taagactaag      600

ccacgagaag agcaatacaa ctcaacgtat cgggtggtga gcgttctgac ggttctgcac      660

caagattggc ttaatggaaa agagtataag tgcaaggtgt ccaacaaggc tcttccggca      720

cccatcgaaa agacgatttc caaagcgaaa ggccaaccta gggaaccgca agtttacact      780

ttgcccccgt caagagacga acttaccaag aatcaagttt ccctgacgtg ccttgtgaag      840

ggcttctacc ctagcgatat agcagttgag tgggaatcta acggccagcc cgaaaataat      900

tataagacta ctccgcccgt gctggacagt gatggttcat ttttcctgta ttcaaaactc      960

actgtggaca aatctagatg gcagcagggt aatgtgttct cttgttcagt tatgcacgag     1020

gcattgcaca atcactatac gcaaaaaagt ttgtctctct ctccgggggg tggaggtggc     1080

tctggaggtg gtggaagcgg tggcggtggt agcaaggcga tgcacgtagc ccagcccgct     1140

gttgttctcg caagttctcg cggcatagcc tccttcgtat gtgagtatgc cagtccaggt     1200

aagtacacgg aggtacgggt aactgtactg cggcaggccg attcccaggt tacggaggtt     1260

tgtgcggcaa cctacatgat gggtaacgag cttacatttc tcgacgactc aatatgtact     1320

gggacctcct caggaaatca ggtcaatctg accatccaag gtctgagggc gatggatacg     1380

ggtctttata tttgcaaggt tgaactcatg tatccgcctc catactatga aggcattgga     1440

aatggaacac aaatctatgt tattgacccg gagccgagcc cagatagtga tcag           1494


<210>  2541
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - Fc - CTLA-4 2520

<400>  2541

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val 
    370                 375                 380                 


Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser 
385                 390                 395                 400 


Pro Gly Lys Tyr Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp 
                405                 410                 415     


Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu 
            420                 425                 430         


Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn 
        435                 440                 445             


Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu 
    450                 455                 460                 


Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly 
465                 470                 475                 480 


Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro 
                485                 490                 495     


Asp Ser Asp Gln 
            500 


<210>  2542
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - Fc - CTLA-4 2520

<400>  2542
ttattcacag tgactgttcc gaaagagttg tatataatcg agcaagggag taatgttacc       60

ctggaatgca attttgacac cgggtcacac gtcaacctcg gagcgattac tgcttctttg      120

caaaaagttg aaaacgacgc gtccccccat agggaaaggg cgacccttct ggaggagcag      180

ttgccccttg gcagggcact ctttcacatt ccccaggtgc aagtcaggga cgaggggcaa      240

taccgctgca tcataattta cggggacgcg tgggactaca agtacttgac tctcaaagtt      300

aaagctggat ccggagggtc tgggggaggc ggttctgagc ccaaaagctc cgacaagact      360

cacacatgcc ccccttgtcc agcgcctgaa gctgagggtg cgccctctgt cttccttttc      420

ccccctaagc cgaaagatac cctgatgatc tcccgcactc ccgaagtcac atgtgttgtt      480

gtcgacgtat ctcatgaaga tcctgaggtg aaattcaact ggtatgtaga cggggtcgaa      540

gttcataatg ctaagactaa gccacgagaa gagcaataca actcaacgta tcgggtggtg      600

agcgttctga cggttctgca ccaagattgg cttaatggaa aagagtataa gtgcaaggtg      660

tccaacaagg ctcttccggc acccatcgaa aagacgattt ccaaagcgaa aggccaacct      720

agggaaccgc aagtttacac tttgcccccg tcaagagacg aacttaccaa gaatcaagtt      780

tccctgacgt gccttgtgaa gggcttctac cctagcgata tagcagttga gtgggaatct      840

aacggccagc ccgaaaataa ttataagact actccgcccg tgctggacag tgatggttca      900

tttttcctgt attcaaaact cactgtggac aaatctagat ggcagcaggg taatgtgttc      960

tcttgttcag ttatgcacga ggcattgcac aatcactata cgcaaaaaag tttgtctctc     1020

tctccggggg gtggaggtgg ctctggaggt ggtggaagcg gtggcggtgg tagcaaggcg     1080

atgcacgtag cccagcccgc tgttgttctc gcaagttctc gcggcatagc ctccttcgta     1140

tgtgagtatg ccagtccagg taagtacacg gaggtacggg taactgtact gcggcaggcc     1200

gattcccagg ttacggaggt ttgtgcggca acctacatga tgggtaacga gcttacattt     1260

ctcgacgact caatatgtac tgggacctcc tcaggaaatc aggtcaatct gaccatccaa     1320

ggtctgaggg cgatggatac gggtctttat atttgcaagg ttgaactcat gtatccgcct     1380

ccatactatg aaggcattgg aaatggaaca caaatctatg ttattgaccc ggagccgagc     1440

ccagatagtg atcag                                                      1455


<210>  2543
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - Fc - CTLA-4 2520

<400>  2543

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            100                 105                 110         


Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
        115                 120                 125             


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
    130                 135                 140                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
145                 150                 155                 160 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                165                 170                 175     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            180                 185                 190         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        195                 200                 205             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    210                 215                 220                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
225                 230                 235                 240 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
                245                 250                 255     


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            260                 265                 270         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        275                 280                 285             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    290                 295                 300                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
305                 310                 315                 320 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                325                 330                 335     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro 
        355                 360                 365             


Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu 
    370                 375                 380                 


Tyr Ala Ser Pro Gly Lys Tyr Thr Glu Val Arg Val Thr Val Leu Arg 
385                 390                 395                 400 


Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met 
                405                 410                 415     


Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser 
            420                 425                 430         


Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp 
        435                 440                 445             


Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr 
    450                 455                 460                 


Tyr Glu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu 
465                 470                 475                 480 


Pro Ser Pro Asp Ser Asp Gln 
                485         


<210>  2544
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K Chain

<400>  2544

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Lys Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  2545
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D chain

<400>  2545

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Asp Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  2546
<211>  1107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - Fc

<400>  2546
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttat tcacagtgac tgttccgaaa gagttgtata taatcgagca agggagtaat      120

gttaccctgg aatgcaattt tgacaccggg tcacacgtca acctcggagc gattactgct      180

tctttgcaaa aagttgaaaa cgacgcgtcc ccccataggg aaagggcgac ccttctggag      240

gagcagttgc cccttggcag ggcactcttt cacattcccc aggtgcaagt cagggacgag      300

gggcaatacc gctgcatcat aatttacggg gacgcgtggg actacaagta cttgactctc      360

aaagttaaag ctgggggagg tggatccgag cccaaaagct ccgacaagac tcacacatgc      420

cccccttgtc cagcgcctga agctgagggt gcgccctctg tcttcctttt cccccctaag      480

ccgaaagata ccctgatgat ctcccgcact cccgaagtca catgtgttgt tgtcgacgta      540

tctcatgaag atcctgaggt gaaattcaac tggtatgtag acggggtcga agttcataat      600

gctaagacta agccacgaga agagcaatac aactcaacgt atcgggtggt gagcgttctg      660

acggttctgc accaagattg gcttaatgga aaagagtata agtgcaaggt gtccaacaag      720

gctcttccgg cacccatcga aaagacgatt tccaaagcga aaggccaacc tagggaaccg      780

caagtttaca ctttgccccc gtcaagaaag aaaatgacca agaatcaagt ttccctgacg      840

tgccttgtga agggcttcta ccctagcgat atagcagttg agtgggaatc taacggccag      900

cccgaaaata attataagac tactccgccc gtgctgaaaa gtgatggttc atttttcctg      960

tattcaaaac tcactgtgga caaatctaga tggcagcagg gtaatgtgtt ctcttgttca     1020

gttatgcacg aggcattgca caatcactat acgcaaaaaa gtttgtctct ctctccgggg     1080

gattacaagg atgacgacga taagtag                                         1107


<210>  2547
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - Fc

<400>  2547

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser 
            100                 105                 110         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
        115                 120                 125             


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    130                 135                 140                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
145                 150                 155                 160 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                165                 170                 175     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            180                 185                 190         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        195                 200                 205             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    210                 215                 220                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
225                 230                 235                 240 


Tyr Thr Leu Pro Pro Ser Arg Lys Lys Met Thr Lys Asn Gln Val Ser 
                245                 250                 255     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            260                 265                 270         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        275                 280                 285             


Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    290                 295                 300                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
305                 310                 315                 320 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                325                 330                 335     


Pro Gly Asp Tyr Lys Asp Asp Asp Asp Lys 
            340                 345     


<210>  2548
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOSL 2244 - Fc

<400>  2548
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgata ctcaggagaa ggaagtcaga gcgatggtag gcagcgacgt ggagctcagc      120

tgcgcttgcc ctgaaggaag ccgttttgat ttaaatgatg tttacgtata ttggcaaacc      180

agtgagtcga aaaccgtggt gacctaccac atcccacaga acagctcctt ggaaaacgtg      240

gacagccgct accggaaccg agccctgatg tcaccggccg gcatgctgcg gggcgacttc      300

tccctgcgct tgttcaacgt caccccccag gacgagcaga agtttcactg cctggtgttg      360

agccaatccc tgggattcca ggaggttttg agcgttgagg ttacactgca tgtggcagca      420

aacttcagcg tggggggagg tggatccgag cccaaaagct ccgacaagac tcacacatgc      480

cccccttgtc cagcgcctga agctgagggt gcgccctctg tcttcctttt cccccctaag      540

ccgaaagata ccctgatgat ctcccgcact cccgaagtca catgtgttgt tgtcgacgta      600

tctcatgaag atcctgaggt gaaattcaac tggtatgtag acggggtcga agttcataat      660

gctaagacta agccacgaga agagcaatac aactcaacgt atcgggtggt gagcgttctg      720

acggttctgc accaagattg gcttaatgga aaagagtata agtgcaaggt gtccaacaag      780

gctcttccgg cacccatcga aaagacgatt tccaaagcga aaggccaacc tagggaaccg      840

caagtttaca ctttgccccc gtcaagagag gaaatgacca agaatcaagt ttccctgacg      900

tgccttgtgg acggcttcta ccctagcgat atagcagttg agtgggaatc taacggccag      960

cccgaaaata attatgacac tactccgccc gtgctggaca gtgatggttc atttttcctg     1020

tattcagacc tcactgtgga caaatctaga tggcagcagg gtaatgtgtt ctcttgttca     1080

gttatgcacg aggcattgca caatcactat acgcaaaaaa gtttgtctct ctctccgggg     1140

caccatcatc accatcacta g                                               1161


<210>  2549
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL 2244 - Fc

<400>  2549

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Asp Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly His His His His His His 
        355                 360                 


<210>  2550
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOSL 2264 - Fc

<400>  2550
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgata ctcaggagaa ggaagtcaga gcgatggtag gcagcgacgt ggagctcagc      120

tgcgcttgcc ctgaaggaag ccgttttgat ttaaatgatg tttacgtata ttggcaaacc      180

agtgagtcga aaaccgtggt gacctaccac atcccacagc acagctcctt ggaatatgtg      240

gacagccgct accggaaccg agccctgatg tcaccggccg gcatgctgcg gggcgacttc      300

tccctgcgct tgttcaacgt caccccccag gacgagcaga agtttcactg cctggtgttg      360

agcagatccc tgggattcca ggaggttttg agcgttgagg ttacactgca tgtggcagca      420

aacttcagcg tggggggagg tggatccgag cccaaaagct ccgacaagac tcacacatgc      480

cccccttgtc cagcgcctga agctgagggt gcgccctctg tcttcctttt cccccctaag      540

ccgaaagata ccctgatgat ctcccgcact cccgaagtca catgtgttgt tgtcgacgta      600

tctcatgaag atcctgaggt gaaattcaac tggtatgtag acggggtcga agttcataat      660

gctaagacta agccacgaga agagcaatac aactcaacgt atcgggtggt gagcgttctg      720

acggttctgc accaagattg gcttaatgga aaagagtata agtgcaaggt gtccaacaag      780

gctcttccgg cacccatcga aaagacgatt tccaaagcga aaggccaacc tagggaaccg      840

caagtttaca ctttgccccc gtcaagagag gaaatgacca agaatcaagt ttccctgacg      900

tgccttgtgg acggcttcta ccctagcgat atagcagttg agtgggaatc taacggccag      960

cccgaaaata attatgacac tactccgccc gtgctggaca gtgatggttc atttttcctg     1020

tattcagacc tcactgtgga caaatctaga tggcagcagg gtaatgtgtt ctcttgttca     1080

gttatgcacg aggcattgca caatcactat acgcaaaaaa gtttgtctct ctctccgggg     1140

caccatcatc accatcacta g                                               1161


<210>  2551
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL 2264 - Fc

<400>  2551

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Asp Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly His His His His His His 
        355                 360                 


<210>  2552
<211>  1146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - Fc

<400>  2552
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttta ccgtaacggt ccctaaggat ttgtacgtgg ttgagtacgg gagcaatatg      120

acgattgaat gcaagttccc cgtagagaag cagctcgatt tggccgcttt gatagtgtac      180

tgggaaatgg aaggaaaaga catcattcaa ttcgtccacg gtgaagagga tcaaaaagcg      240

caacatagct cctatagaca acgcgcacgc ttgcttaaag accagctgag tcttggtaac      300

gcggcgctgc agattaccga cgtaaaactt caagacgcgg gagtttatcg ctgcatgatt      360

tcctacgggg gtggcgcaga ctataaaagg atcactgtaa aggtaaacgc cgggggaggt      420

ggatccgagc ccaaaagctc cgacaagact cacacatgcc ccccttgtcc agcgcctgaa      480

gctgagggtg cgccctctgt cttccttttc ccccctaagc cgaaagatac cctgatgatc      540

tcccgcactc ccgaagtcac atgtgttgtt gtcgacgtat ctcatgaaga tcctgaggtg      600

aaattcaact ggtatgtaga cggggtcgaa gttcataatg ctaagactaa gccacgagaa      660

gagcaataca actcaacgta tcgggtggtg agcgttctga cggttctgca ccaagattgg      720

cttaatggaa aagagtataa gtgcaaggtg tccaacaagg ctcttccggc acccatcgaa      780

aagacgattt ccaaagcgaa aggccaacct agggaaccgc aagtttacac tttgcccccg      840

tcaagaaaga aaatgaccaa gaatcaagtt tccctgacgt gccttgtgaa gggcttctac      900

cctagcgata tagcagttga gtgggaatct aacggccagc ccgaaaataa ttataagact      960

actccgcccg tgctgaaaag tgatggttca tttttcctgt attcaaaact cactgtggac     1020

aaatctagat ggcagcaggg taatgtgttc tcttgttcag ttatgcacga ggcattgcac     1080

aatcactata cgcaaaaaag tttgtctctc tctccggggg attacaagga tgacgacgat     1140

aagtga                                                                1146


<210>  2553
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - Fc

<400>  2553

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
        115                 120                 125             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser 
    130                 135                 140                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
145                 150                 155                 160 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                165                 170                 175     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            180                 185                 190         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        195                 200                 205             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    210                 215                 220                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
225                 230                 235                 240 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                245                 250                 255     


Pro Pro Ser Arg Lys Lys Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            260                 265                 270         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        275                 280                 285             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Lys 
    290                 295                 300                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
305                 310                 315                 320 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                325                 330                 335     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Asp 
            340                 345                 350         


Tyr Lys Asp Asp Asp Asp Lys 
        355                 


<210>  2554
<211>  1119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD80 2615 - Fc

<400>  2554
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgtta tccacgtgac caaggaagtg aaagaagtgg caacgctgtc ctgtggtcac      120

aatgtttctg ttgaagagct ggcacaaact cgcatctact ggcaaaagga gaagaaaatg      180

gtgctgacta tgatgtctgg ggacatgaat atatggcccg agtacaagaa ccggaccatc      240

tttgacatca ctaataacct ctccattgtg atcctggctc tgcgcccatc tgacgagggc      300

acatacgagt gtgttgttct gaagtatgaa aaagacgctt tcaagcggga acacctggct      360

gaagtgacgt tatcagtcaa agctgacttc gggggaggtg gatccgagcc caaaagctcc      420

gacaagactc acacatgccc cccttgtcca gcgcctgaag ctgagggtgc gccctctgtc      480

ttccttttcc cccctaagcc gaaagatacc ctgatgatct cccgcactcc cgaagtcaca      540

tgtgttgttg tcgacgtatc tcatgaagat cctgaggtga aattcaactg gtatgtagac      600

ggggtcgaag ttcataatgc taagactaag ccacgagaag agcaatacaa ctcaacgtat      660

cgggtggtga gcgttctgac ggttctgcac caagattggc ttaatggaaa agagtataag      720

tgcaaggtgt ccaacaaggc tcttccggca cccatcgaaa agacgatttc caaagcgaaa      780

ggccaaccta gggaaccgca agtttacact ttgcccccgt caagagagga aatgaccaag      840

aatcaagttt ccctgacgtg ccttgtggac ggcttctacc ctagcgatat agcagttgag      900

tgggaatcta acggccagcc cgaaaataat tatgacacta ctccgcccgt gctggacagt      960

gatggttcat ttttcctgta ttcagacctc actgtggaca aatctagatg gcagcagggt     1020

aatgtgttct cttgttcagt tatgcacgag gcattgcaca atcactatac gcaaaaaagt     1080

ttgtctctct ctccggggca ccatcatcac catcactag                            1119


<210>  2555
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 2615 - Fc

<400>  2555

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Gly Gly Gly Gly 
            100                 105                 110         


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        115                 120                 125             


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
    130                 135                 140                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
145                 150                 155                 160 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                165                 170                 175     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            180                 185                 190         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        195                 200                 205             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    210                 215                 220                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
225                 230                 235                 240 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                245                 250                 255     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Asp Gly Phe Tyr Pro 
            260                 265                 270         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        275                 280                 285             


Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    290                 295                 300                 


Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
305                 310                 315                 320 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                325                 330                 335     


Lys Ser Leu Ser Leu Ser Pro Gly His His His His His His 
            340                 345                 350 


<210>  2556
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD80 1152 - Fc

<400>  2556
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgtta tccacgtgac caaggaagtg aaagaagtgg caacgctgtc ctgtggtcac      120

aatgtttctc tggaagagct ggcacaaact cgcatctact ggcaaaaggg taagaaaatg      180

gtgctgacta tgatgtctgg ggacatgaat atatggcccg agtacaagaa ccggaccatc      240

tttgacatca ctaataacct ctccattgtg atcctggacc cacgcccatc tgacgagggc      300

acatacgagt gtgttgttct gaagtatgaa aaagacgctt tcaagcggga acacctggct      360

gaagtggggg gaggtggatc cgagcccaaa agctccgaca agactcacac atgcccccct      420

tgtccagcgc ctgaagctga gggtgcgccc tctgtcttcc ttttcccccc taagccgaaa      480

gataccctga tgatctcccg cactcccgaa gtcacatgtg ttgttgtcga cgtatctcat      540

gaagatcctg aggtgaaatt caactggtat gtagacgggg tcgaagttca taatgctaag      600

actaagccac gagaagagca atacaactca acgtatcggg tggtgagcgt tctgacggtt      660

ctgcaccaag attggcttaa tggaaaagag tataagtgca aggtgtccaa caaggctctt      720

ccggcaccca tcgaaaagac gatttccaaa gcgaaaggcc aacctaggga accgcaagtt      780

tacactttgc ccccgtcaag agaggaaatg accaagaatc aagtttccct gacgtgcctt      840

gtggacggct tctaccctag cgatatagca gttgagtggg aatctaacgg ccagcccgaa      900

aataattatg acactactcc gcccgtgctg gacagtgatg gttcattttt cctgtattca      960

gacctcactg tggacaaatc tagatggcag cagggtaatg tgttctcttg ttcagttatg     1020

cacgaggcat tgcacaatca ctatacgcaa aaaagtttgt ctctctctcc ggggcaccat     1080

catcaccatc actag                                                      1095


<210>  2557
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 1152 - Fc

<400>  2557

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys 
            100                 105                 110         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro 
        115                 120                 125             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    130                 135                 140                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
145                 150                 155                 160 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                165                 170                 175     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            180                 185                 190         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        195                 200                 205             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    210                 215                 220                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
225                 230                 235                 240 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                245                 250                 255     


Cys Leu Val Asp Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            260                 265                 270         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu 
        275                 280                 285             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu Thr Val Asp Lys 
    290                 295                 300                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
305                 310                 315                 320 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 330                 335     


His His His His His His 
            340         


<210>  2558
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Knob Fc

<400>  2558

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  2559
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hole Fc

<400>  2559

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  2560
<211>  1170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - Fc

<400>  2560
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttta ccgtaacggt ccctaaggat ttgtacgtgg ttgagtacgg gagcaatatg      120

acgattgaat gcaagttccc cgtagagaag cagctcgatt tggccgcttt gatagtgtac      180

tgggaaatgg aaggaaaaga catcattcaa ttcgtccacg gtgaagagga tcaaaaagcg      240

caacatagct cctatagaca acgcgcacgc ttgcttaaag accagctgag tcttggtaac      300

gcggcgctgc agattaccga cgtaaaactt caagacgcgg gagtttatcg ctgcatgatt      360

tcctacgggg gtggcgcaga ctataaaagg atcactgtaa aggtaaacgc cggatccgga      420

gggtctgggg gaggcggttc tgggggtgga ggctcagagc ccaaaagctc cgacaagact      480

cacacatgcc ccccttgtcc agcgcctgaa gctgagggtg cgccctctgt cttccttttc      540

ccccctaagc cgaaagatac cctgatgatc tcccgcactc ccgaagtcac atgtgttgtt      600

gtcgacgtat ctcatgaaga tcctgaggtg aaattcaact ggtatgtaga cggggtcgaa      660

gttcataatg ctaagactaa gccacgagaa gagcaataca actcaacgta tcgggtggtg      720

agcgttctga cggttctgca ccaagattgg cttaatggaa aagagtataa gtgcaaggtg      780

tccaacaagg ctcttccggc acccatcgaa aagacgattt ccaaagcgaa aggccaacct      840

agggaaccgc aagtttgcac tttgcccccg tcaagagaag aaatgaccaa gaatcaagtt      900

tccctgtctt gcgcagtgaa gggcttctac cctagcgata tagcagttga gtgggaatct      960

aacggccagc ccgaaaataa ttataagact actccgcccg tgctggacag tgatggttca     1020

tttttcctgg tttcaaaact cactgtggac aaatctagat ggcagcaggg taatgtgttc     1080

tcttgttcag ttatgcacga ggcattgcac aatcactata cgcaaaaaag tttgtctctc     1140

tctccggggc accatcatca ccatcactag                                      1170


<210>  2561
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - Fc

<400>  2561

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
    130                 135                 140                 


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
145                 150                 155                 160 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                165                 170                 175     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            180                 185                 190         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        195                 200                 205             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    210                 215                 220                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
225                 230                 235                 240 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                245                 250                 255     


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu 
            260                 265                 270         


Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
        275                 280                 285             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    290                 295                 300                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
305                 310                 315                 320 


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                325                 330                 335     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Lys Ser Leu Ser Leu Ser Pro Gly His His His His His His 
        355                 360                 365         


<210>  2562
<211>  1239
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OKT3 - PD-L1 303

<400>  2562
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctcagg tccagctgca gcagtctggg gctgaactgg caagacctgg ggcctcagtg      120

aagatgtcct gcaaggcttc tggctacacc tttactaggt acacgatgca ctgggtaaaa      180

cagaggcctg gacagggtct ggaatggatt ggatacatta atcctagccg tggttatact      240

aattacaatc agaagttcaa ggacaaggcc acattgacta cagacaaatc ctccagcaca      300

gcctacatgc aactgagcag cctgacatct gaggactctg cagtctatta ctgtgcaaga      360

tattatgatg atcattactg ccttgactac tggggccaag gcaccacggt gaccgtgagc      420

gccgggggag gtggcagcgg gggaggtggc agcggcggcg ggagctccca aattgttctc      480

acccagtctc cagcaatcat gtctgcatct ccaggggaga aggtcaccat gacctgcagt      540

gccagctcaa gtgtaagtta catgaactgg taccagcaga agtcaggcac ctcccccaaa      600

agatggattt atgacacatc caaactggct tctggagtcc ctgctcactt caggggcagt      660

gggtctggga cctcttactc tctcacaatc agcggcatgg aggctgaaga tgctgccact      720

tattactgcc agcagtggag tagtaaccca ttcacgttcg gctcggggac aaagttggaa      780

ataaaccggg gcggtggcga tcccggatcc ggagggtctg ggggaggcgg ttctgggggt      840

ggaggctcat ttaccgtaac ggtccctaag gatttgtacg tggttgagta cgggagcaat      900

atgacgattg aatgcaagtt ccccgtagag aagcagctcg atttggccgc tttgatagtg      960

tactgggaaa tggaaggaaa agacatcatt caattcgtcc acggtgaaga ggatcaaaaa     1020

gcgcaacata gctcctatag acaacgcgca cgcttgctta aagaccagct gagtcttggt     1080

aacgcggcgc tgcagattac cgacgtaaaa cttcaagacg cgggagttta tcgctgcatg     1140

atttcctacg ggggtggcgc agactataaa aggatcactg taaaggtaaa cgccgattac     1200

aaggatgacg acgataagca ccatcatcac catcactag                            1239


<210>  2563
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 - PD-L1 303

<400>  2563

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
225                 230                 235                 240 


Arg Gly Gly Gly Asp Pro Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val 
            260                 265                 270         


Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu 
        275                 280                 285             


Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly 
    290                 295                 300                 


Lys Asp Ile Ile Gln Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln 
305                 310                 315                 320 


His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser 
                325                 330                 335     


Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala 
            340                 345                 350         


Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys 
        355                 360                 365             


Arg Ile Thr Val Lys Val Asn Ala Asp Tyr Lys Asp Asp Asp Asp Lys 
    370                 375                 380                 


His His His His His His 
385                 390 


<210>  2564
<211>  1200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OKT3 - PD-L2 1417

<400>  2564
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctcagg tccagctgca gcagtctggg gctgaactgg caagacctgg ggcctcagtg      120

aagatgtcct gcaaggcttc tggctacacc tttactaggt acacgatgca ctgggtaaaa      180

cagaggcctg gacagggtct ggaatggatt ggatacatta atcctagccg tggttatact      240

aattacaatc agaagttcaa ggacaaggcc acattgacta cagacaaatc ctccagcaca      300

gcctacatgc aactgagcag cctgacatct gaggactctg cagtctatta ctgtgcaaga      360

tattatgatg atcattactg ccttgactac tggggccaag gcaccacggt gaccgtgagc      420

gccgggggag gtggcagcgg gggaggtggc agcggcggcg ggagctccca aattgttctc      480

acccagtctc cagcaatcat gtctgcatct ccaggggaga aggtcaccat gacctgcagt      540

gccagctcaa gtgtaagtta catgaactgg taccagcaga agtcaggcac ctcccccaaa      600

agatggattt atgacacatc caaactggct tctggagtcc ctgctcactt caggggcagt      660

gggtctggga cctcttactc tctcacaatc agcggcatgg aggctgaaga tgctgccact      720

tattactgcc agcagtggag tagtaaccca ttcacgttcg gctcggggac aaagttggaa      780

ataaaccggg gcggtggcga tcccggatcc ggagggtctg ggggaggcgg ttctgggggt      840

ggaggctcat tattcacagt gactgttccg aaagagttgt atataatcga gcaagggagt      900

aatgttaccc tggaatgcaa ttttgacacc gggtcacacg tcaacctcgg agcgattact      960

gcttctttgc aaaaagttga aaacgacgcg tccccccata gggaaagggc gacccttctg     1020

gaggagcagt tgccccttgg cagggcactc tttcacattc cccaggtgca agtcagggac     1080

gaggggcaat accgctgcat cataatttac ggggacgcgt gggactacaa gtacttgact     1140

ctcaaagtta aagctgatta caaggatgac gacgataagc accatcatca ccatcactag     1200


<210>  2565
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 - PD-L2 1417

<400>  2565

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
225                 230                 235                 240 


Arg Gly Gly Gly Asp Pro Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr 
            260                 265                 270         


Ile Ile Glu Gln Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr 
        275                 280                 285             


Gly Ser His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val 
    290                 295                 300                 


Glu Asn Asp Ala Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu 
305                 310                 315                 320 


Gln Leu Pro Leu Gly Arg Ala Leu Phe His Ile Pro Gln Val Gln Val 
                325                 330                 335     


Arg Asp Glu Gly Gln Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp 
            340                 345                 350         


Asp Tyr Lys Tyr Leu Thr Leu Lys Val Lys Ala Asp Tyr Lys Asp Asp 
        355                 360                 365             


Asp Asp Lys His His His His His His 
    370                 375         


<210>  2566
<211>  1230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - OKT3

<400>  2566
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctttt       60

accgtaacgg tccctaagga tttgtacgtg gttgagtacg ggagcaatat gacgattgaa      120

tgcaagttcc ccgtagagaa gcagctcgat ttggccgctt tgatagtgta ctgggaaatg      180

gaaggaaaag acatcattca attcgtccac ggtgaagagg atcaaaaagc gcaacatagc      240

tcctatagac aacgcgcacg cttgcttaaa gaccagctga gtcttggtaa cgcggcgctg      300

cagattaccg acgtaaaact tcaagacgcg ggagtttatc gctgcatgat ttcctacggg      360

ggtggcgcag actataaaag gatcactgta aaggtaaacg ccggatccgg agggtctggg      420

ggaggcggtt ctgggggtgg aggctcacag gtccagctgc agcagtctgg ggctgaactg      480

gcaagacctg gggcctcagt gaagatgtcc tgcaaggctt ctggctacac ctttactagg      540

tacacgatgc actgggtaaa acagaggcct ggacagggtc tggaatggat tggatacatt      600

aatcctagcc gtggttatac taattacaat cagaagttca aggacaaggc cacattgact      660

acagacaaat cctccagcac agcctacatg caactgagca gcctgacatc tgaggactct      720

gcagtctatt actgtgcaag atattatgat gatcattact gccttgacta ctggggccaa      780

ggcaccacgg tgaccgtgag cgccggggga ggtggcagcg ggggaggtgg cagcggcggc      840

gggagctccc aaattgttct cacccagtct ccagcaatca tgtctgcatc tccaggggag      900

aaggtcacca tgacctgcag tgccagctca agtgtaagtt acatgaactg gtaccagcag      960

aagtcaggca cctcccccaa aagatggatt tatgacacat ccaaactggc ttctggagtc     1020

cctgctcact tcaggggcag tgggtctggg acctcttact ctctcacaat cagcggcatg     1080

gaggctgaag atgctgccac ttattactgc cagcagtgga gtagtaaccc attcacgttc     1140

ggctcgggga caaagttgga aataaaccgg ggcggtggcg atcccgatta caaggatgac     1200

gacgataagc accatcatca ccatcactag                                      1230


<210>  2567
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - OKT3

<400>  2567

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro 
    130                 135                 140                 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
145                 150                 155                 160 


Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln 
            180                 185                 190         


Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr 
        195                 200                 205             


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Ser Ser Gln Ile Val Leu Thr Gln Ser Pro 
            260                 265                 270         


Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser 
        275                 280                 285             


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly 
    290                 295                 300                 


Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
305                 310                 315                 320 


Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
                325                 330                 335     


Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            340                 345                 350         


Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        355                 360                 365             


Ile Asn Arg Gly Gly Gly Asp Pro Asp Tyr Lys Asp Asp Asp Asp Lys 
    370                 375                 380                 


His His His His His His 
385                 390 


<210>  2568
<211>  1191
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - OKT3

<400>  2568
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgcttta       60

ttcacagtga ctgttccgaa agagttgtat ataatcgagc aagggagtaa tgttaccctg      120

gaatgcaatt ttgacaccgg gtcacacgtc aacctcggag cgattactgc ttctttgcaa      180

aaagttgaaa acgacgcgtc cccccatagg gaaagggcga cccttctgga ggagcagttg      240

ccccttggca gggcactctt tcacattccc caggtgcaag tcagggacga ggggcaatac      300

cgctgcatca taatttacgg ggacgcgtgg gactacaagt acttgactct caaagttaaa      360

gctggatccg gagggtctgg gggaggcggt tctgggggtg gaggctcaca ggtccagctg      420

cagcagtctg gggctgaact ggcaagacct ggggcctcag tgaagatgtc ctgcaaggct      480

tctggctaca cctttactag gtacacgatg cactgggtaa aacagaggcc tggacagggt      540

ctggaatgga ttggatacat taatcctagc cgtggttata ctaattacaa tcagaagttc      600

aaggacaagg ccacattgac tacagacaaa tcctccagca cagcctacat gcaactgagc      660

agcctgacat ctgaggactc tgcagtctat tactgtgcaa gatattatga tgatcattac      720

tgccttgact actggggcca aggcaccacg gtgaccgtga gcgccggggg aggtggcagc      780

gggggaggtg gcagcggcgg cgggagctcc caaattgttc tcacccagtc tccagcaatc      840

atgtctgcat ctccagggga gaaggtcacc atgacctgca gtgccagctc aagtgtaagt      900

tacatgaact ggtaccagca gaagtcaggc acctccccca aaagatggat ttatgacaca      960

tccaaactgg cttctggagt ccctgctcac ttcaggggca gtgggtctgg gacctcttac     1020

tctctcacaa tcagcggcat ggaggctgaa gatgctgcca cttattactg ccagcagtgg     1080

agtagtaacc cattcacgtt cggctcgggg acaaagttgg aaataaaccg gggcggtggc     1140

gatcccgatt acaaggatga cgacgataag caccatcatc accatcacta g              1191


<210>  2569
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - OKT3

<400>  2569

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu 
        115                 120                 125             


Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
    130                 135                 140                 


Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln 
145                 150                 155                 160 


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn 
                165                 170                 175     


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser 
            180                 185                 190         


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
        195                 200                 205             


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Ser Gln Ile Val Leu Thr 
                245                 250                 255     


Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
            260                 265                 270         


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
        275                 280                 285             


Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu 
    290                 295                 300                 


Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser 
305                 310                 315                 320 


Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr 
                325                 330                 335     


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr 
            340                 345                 350         


Lys Leu Glu Ile Asn Arg Gly Gly Gly Asp Pro Asp Tyr Lys Asp Asp 
        355                 360                 365             


Asp Asp Lys His His His His His His 
    370                 375         


<210>  2570
<211>  855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - IL16

<400>  2570
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctttt       60

accgtaacgg tccctaagga tttgtacgtg gttgagtacg ggagcaatat gacgattgaa      120

tgcaagttcc ccgtagagaa gcagctcgat ttggccgctt tgatagtgta ctgggaaatg      180

gaaggaaaag acatcattca attcgtccac ggtgaagagg atcaaaaagc gcaacatagc      240

tcctatagac aacgcgcacg cttgcttaaa gaccagctga gtcttggtaa cgcggcgctg      300

cagattaccg acgtaaaact tcaagacgcg ggagtttatc gctgcatgat ttcctacggg      360

ggtggcgcag actataaaag gatcactgta aaggtaaacg ccggatccgg agggtctggg      420

ggaggcggtt ctgggggtgg aggctcaagc gccgcttctg cctcagcagc cagcgatgtc      480

tctgtcgaaa gcacggcgga agctactgtt tgtactgtca cccttgagaa aatgagcgcg      540

ggtttggggt tttcactcga gggcggcaaa gggtcacttc acggcgacaa accattgaca      600

atcaatcgga tatttaaagg tgctgcctct gaacagagcg aaactgttca accgggcgat      660

gaaatactgc aactgggtgg tacagccatg cagggcctga cgcgcttcga ggcgtggaac      720

attataaaag cactgcctga tggtccagtc acaatagtca tccgccggaa atcacttcaa      780

tcaaaggaga ccaccgctgc gggagacagc gattacaagg atgacgacga taagcaccat      840

catcaccatc actag                                                       855


<210>  2571
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - IL16

<400>  2571

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu 
    130                 135                 140                 


Ser Thr Ala Glu Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser 
145                 150                 155                 160 


Ala Gly Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly 
                165                 170                 175     


Asp Lys Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu 
            180                 185                 190         


Gln Ser Glu Thr Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly 
        195                 200                 205             


Thr Ala Met Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys 
    210                 215                 220                 


Ala Leu Pro Asp Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu 
225                 230                 235                 240 


Gln Ser Lys Glu Thr Thr Ala Ala Gly Asp Ser Asp Tyr Lys Asp Asp 
                245                 250                 255     


Asp Asp Lys His His His His His His 
            260                 265 


<210>  2572
<211>  855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL16 - PD-L1 303

<400>  2572
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctagc       60

gccgcttctg cctcagcagc cagcgatgtc tctgtcgaaa gcacggcgga agctactgtt      120

tgtactgtca cccttgagaa aatgagcgcg ggtttggggt tttcactcga gggcggcaaa      180

gggtcacttc acggcgacaa accattgaca atcaatcgga tatttaaagg tgctgcctct      240

gaacagagcg aaactgttca accgggcgat gaaatactgc aactgggtgg tacagccatg      300

cagggcctga cgcgcttcga ggcgtggaac attataaaag cactgcctga tggtccagtc      360

acaatagtca tccgccggaa atcacttcaa tcaaaggaga ccaccgctgc gggagacagc      420

ggatccggag ggtctggggg aggcggttct gggggtggag gctcatttac cgtaacggtc      480

cctaaggatt tgtacgtggt tgagtacggg agcaatatga cgattgaatg caagttcccc      540

gtagagaagc agctcgattt ggccgctttg atagtgtact gggaaatgga aggaaaagac      600

atcattcaat tcgtccacgg tgaagaggat caaaaagcgc aacatagctc ctatagacaa      660

cgcgcacgct tgcttaaaga ccagctgagt cttggtaacg cggcgctgca gattaccgac      720

gtaaaacttc aagacgcggg agtttatcgc tgcatgattt cctacggggg tggcgcagac      780

tataaaagga tcactgtaaa ggtaaacgcc gattacaagg atgacgacga taagcaccat      840

catcaccatc actag                                                       855


<210>  2573
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL16 - PD-L1 303

<400>  2573

Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr 
1               5                   10                  15      


Ala Glu Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly 
            20                  25                  30          


Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys 
        35                  40                  45              


Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser 
    50                  55                  60                  


Glu Thr Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala 
65                  70                  75                  80  


Met Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu 
                85                  90                  95      


Pro Asp Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser 
            100                 105                 110         


Lys Glu Thr Thr Ala Ala Gly Asp Ser Gly Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val Pro Lys Asp 
    130                 135                 140                 


Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe 
145                 150                 155                 160 


Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu 
                165                 170                 175     


Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu Glu Asp Gln 
            180                 185                 190         


Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp 
        195                 200                 205             


Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu 
    210                 215                 220                 


Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala 
225                 230                 235                 240 


Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Asp Tyr Lys Asp Asp 
                245                 250                 255     


Asp Asp Lys His His His His His His 
            260                 265 


<210>  2574
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - IL16

<400>  2574
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttat tcacagtgac tgttccgaaa gagttgtata taatcgagca agggagtaat      120

gttaccctgg aatgcaattt tgacaccggg tcacacgtca acctcggagc gattactgct      180

tctttgcaaa aagttgaaaa cgacgcgtcc ccccataggg aaagggcgac ccttctggag      240

gagcagttgc cccttggcag ggcactcttt cacattcccc aggtgcaagt cagggacgag      300

gggcaatacc gctgcatcat aatttacggg gacgcgtggg actacaagta cttgactctc      360

aaagttaaag ctggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcaagc      420

gccgcttctg cctcagcagc cagcgatgtc tctgtcgaaa gcacggcgga agctactgtt      480

tgtactgtca cccttgagaa aatgagcgcg ggtttggggt tttcactcga gggcggcaaa      540

gggtcacttc acggcgacaa accattgaca atcaatcgga tatttaaagg tgctgcctct      600

gaacagagcg aaactgttca accgggcgat gaaatactgc aactgggtgg tacagccatg      660

cagggcctga cgcgcttcga ggcgtggaac attataaaag cactgcctga tggtccagtc      720

acaatagtca tccgccggaa atcacttcaa tcaaaggaga ccaccgctgc gggagacagc      780

gattacaagg atgacgacga taagcaccat catcaccatc actag                      825


<210>  2575
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - IL16

<400>  2575

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val 
        115                 120                 125             


Ser Val Glu Ser Thr Ala Glu Ala Thr Val Cys Thr Val Thr Leu Glu 
    130                 135                 140                 


Lys Met Ser Ala Gly Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser 
145                 150                 155                 160 


Leu His Gly Asp Lys Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala 
                165                 170                 175     


Ala Ser Glu Gln Ser Glu Thr Val Gln Pro Gly Asp Glu Ile Leu Gln 
            180                 185                 190         


Leu Gly Gly Thr Ala Met Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn 
        195                 200                 205             


Ile Ile Lys Ala Leu Pro Asp Gly Pro Val Thr Ile Val Ile Arg Arg 
    210                 215                 220                 


Lys Ser Leu Gln Ser Lys Glu Thr Thr Ala Ala Gly Asp Ser Asp Tyr 
225                 230                 235                 240 


Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250         


<210>  2576
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL16 - PD-L2 1417

<400>  2576
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctagcg ccgcttctgc ctcagcagcc agcgatgtct ctgtcgaaag cacggcggaa      120

gctactgttt gtactgtcac ccttgagaaa atgagcgcgg gtttggggtt ttcactcgag      180

ggcggcaaag ggtcacttca cggcgacaaa ccattgacaa tcaatcggat atttaaaggt      240

gctgcctctg aacagagcga aactgttcaa ccgggcgatg aaatactgca actgggtggt      300

acagccatgc agggcctgac gcgcttcgag gcgtggaaca ttataaaagc actgcctgat      360

ggtccagtca caatagtcat ccgccggaaa tcacttcaat caaaggagac caccgctgcg      420

ggagacagcg gatccggagg gtctggggga ggcggttctg ggggtggagg ctcattattc      480

acagtgactg ttccgaaaga gttgtatata atcgagcaag ggagtaatgt taccctggaa      540

tgcaattttg acaccgggtc acacgtcaac ctcggagcga ttactgcttc tttgcaaaaa      600

gttgaaaacg acgcgtcccc ccatagggaa agggcgaccc ttctggagga gcagttgccc      660

cttggcaggg cactctttca cattccccag gtgcaagtca gggacgaggg gcaataccgc      720

tgcatcataa tttacgggga cgcgtgggac tacaagtact tgactctcaa agttaaagct      780

gattacaagg atgacgacga taagcaccat catcaccatc actag                      825


<210>  2577
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL16 - PD-L2 1417

<400>  2577

Ser Ala Ala Ser Ala Ser Ala Ala Ser Asp Val Ser Val Glu Ser Thr 
1               5                   10                  15      


Ala Glu Ala Thr Val Cys Thr Val Thr Leu Glu Lys Met Ser Ala Gly 
            20                  25                  30          


Leu Gly Phe Ser Leu Glu Gly Gly Lys Gly Ser Leu His Gly Asp Lys 
        35                  40                  45              


Pro Leu Thr Ile Asn Arg Ile Phe Lys Gly Ala Ala Ser Glu Gln Ser 
    50                  55                  60                  


Glu Thr Val Gln Pro Gly Asp Glu Ile Leu Gln Leu Gly Gly Thr Ala 
65                  70                  75                  80  


Met Gln Gly Leu Thr Arg Phe Glu Ala Trp Asn Ile Ile Lys Ala Leu 
                85                  90                  95      


Pro Asp Gly Pro Val Thr Ile Val Ile Arg Arg Lys Ser Leu Gln Ser 
            100                 105                 110         


Lys Glu Thr Thr Ala Ala Gly Asp Ser Gly Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Leu Phe Thr Val Thr Val Pro Lys 
    130                 135                 140                 


Glu Leu Tyr Ile Ile Glu Gln Gly Ser Asn Val Thr Leu Glu Cys Asn 
145                 150                 155                 160 


Phe Asp Thr Gly Ser His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu 
                165                 170                 175     


Gln Lys Val Glu Asn Asp Ala Ser Pro His Arg Glu Arg Ala Thr Leu 
            180                 185                 190         


Leu Glu Glu Gln Leu Pro Leu Gly Arg Ala Leu Phe His Ile Pro Gln 
        195                 200                 205             


Val Gln Val Arg Asp Glu Gly Gln Tyr Arg Cys Ile Ile Ile Tyr Gly 
    210                 215                 220                 


Asp Ala Trp Asp Tyr Lys Tyr Leu Thr Leu Lys Val Lys Ala Asp Tyr 
225                 230                 235                 240 


Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250         


<210>  2578
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - ICOSL 2247

<400>  2578
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttat tcacagtgac tgttccgaaa gagttgtata taatcgagca agggagtaat      120

gttaccctgg aatgcaattt tgacaccggg tcacacgtca acctcggagc gattactgct      180

tctttgcaaa aagttgaaaa cgacgcgtcc ccccataggg aaagggcgac ccttctggag      240

gagcagttgc cccttggcag ggcactcttt cacattcccc aggtgcaagt cagggacgag      300

gggcaatacc gctgcatcat aatttacggg gacgcgtggg actacaagta cttgactctc      360

aaagttaaag ctggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcagat      420

actcaggaga aggaagtcag agcgatggta ggcagcgacg tggagctcag ctgcgcttgc      480

cctgaaggaa gccgttttga tttaaatgat gtttacgtat attggcaaac cagtgagtcg      540

aaaaccgtgg tgacctacca catcccacag gacagctcct tggaaaacgt ggacagccgc      600

taccggaacc gagccctgat gtcaccggcc ggcatgctgc ggggcgactt ctccctgcgc      660

ttgttcaacg tcacccccca ggacgagcag aagtttcact gcctggtgtt gagccaatcc      720

ctgggattcc aggaggtttt gagcgttgag gttacactgc atgtggcagc aaacttcagc      780

gtggattaca aggatgacga cgataagcac catcatcacc atcactag                   828


<210>  2579
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - ICOSL 2247

<400>  2579

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val 
        115                 120                 125             


Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe 
    130                 135                 140                 


Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr 
145                 150                 155                 160 


Val Val Thr Tyr His Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp 
                165                 170                 175     


Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg 
            180                 185                 190         


Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln 
        195                 200                 205             


Lys Phe His Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val 
    210                 215                 220                 


Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250             


<210>  2580
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOSL 2247 - PD-L2 1417

<400>  2580
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgata ctcaggagaa ggaagtcaga gcgatggtag gcagcgacgt ggagctcagc      120

tgcgcttgcc ctgaaggaag ccgttttgat ttaaatgatg tttacgtata ttggcaaacc      180

agtgagtcga aaaccgtggt gacctaccac atcccacagg acagctcctt ggaaaacgtg      240

gacagccgct accggaaccg agccctgatg tcaccggccg gcatgctgcg gggcgacttc      300

tccctgcgct tgttcaacgt caccccccag gacgagcaga agtttcactg cctggtgttg      360

agccaatccc tgggattcca ggaggttttg agcgttgagg ttacactgca tgtggcagca      420

aacttcagcg tgggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcatta      480

ttcacagtga ctgttccgaa agagttgtat ataatcgagc aagggagtaa tgttaccctg      540

gaatgcaatt ttgacaccgg gtcacacgtc aacctcggag cgattactgc ttctttgcaa      600

aaagttgaaa acgacgcgtc cccccatagg gaaagggcga cccttctgga ggagcagttg      660

ccccttggca gggcactctt tcacattccc caggtgcaag tcagggacga ggggcaatac      720

cgctgcatca taatttacgg ggacgcgtgg gactacaagt acttgactct caaagttaaa      780

gctgattaca aggatgacga cgataagcac catcatcacc atcactag                   828


<210>  2581
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL 2247 - PD-L2 1417

<400>  2581

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Phe Thr Val Thr Val Pro 
    130                 135                 140                 


Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser Asn Val Thr Leu Glu Cys 
145                 150                 155                 160 


Asn Phe Asp Thr Gly Ser His Val Asn Leu Gly Ala Ile Thr Ala Ser 
                165                 170                 175     


Leu Gln Lys Val Glu Asn Asp Ala Ser Pro His Arg Glu Arg Ala Thr 
            180                 185                 190         


Leu Leu Glu Glu Gln Leu Pro Leu Gly Arg Ala Leu Phe His Ile Pro 
        195                 200                 205             


Gln Val Gln Val Arg Asp Glu Gly Gln Tyr Arg Cys Ile Ile Ile Tyr 
    210                 215                 220                 


Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr Leu Lys Val Lys Ala Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250             


<210>  2582
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - ICOSL 2266

<400>  2582
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttat tcacagtgac tgttccgaaa gagttgtata taatcgagca agggagtaat      120

gttaccctgg aatgcaattt tgacaccggg tcacacgtca acctcggagc gattactgct      180

tctttgcaaa aagttgaaaa cgacgcgtcc ccccataggg aaagggcgac ccttctggag      240

gagcagttgc cccttggcag ggcactcttt cacattcccc aggtgcaagt cagggacgag      300

gggcaatacc gctgcatcat aatttacggg gacgcgtggg actacaagta cttgactctc      360

aaagttaaag ctggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcagat      420

actcaggaga aggaagtcag agcgatggta ggcagcgacg tggagctcag ctgcgcttgc      480

cctgaaggaa gccgttttga tttaaatgat gtttacgtat attggcaaac cagtgagtcg      540

aaaaccgtgg tgacctacca catcccacag cacagctcct tggaaaacgt ggacagccgc      600

taccggaacc gagccctgat gtcaccggcc ggcatgctgc ggggcgactt ctccctgcgc      660

ttgttcaacg tcacccccca ggacgagcag aagtttcact gcctggtgtt gagcagatcc      720

ctgggattcc aggaggtttt gagcgttgag gttacactgc atgtggcagc aaacttcagc      780

gtggattaca aggatgacga cgataagcac catcatcacc atcactag                   828


<210>  2583
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - ICOSL 2266

<400>  2583

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val 
        115                 120                 125             


Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe 
    130                 135                 140                 


Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr 
145                 150                 155                 160 


Val Val Thr Tyr His Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp 
                165                 170                 175     


Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg 
            180                 185                 190         


Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln 
        195                 200                 205             


Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val 
    210                 215                 220                 


Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250             


<210>  2584
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOSL 2266 - PD-L2 1417

<400>  2584
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgata ctcaggagaa ggaagtcaga gcgatggtag gcagcgacgt ggagctcagc      120

tgcgcttgcc ctgaaggaag ccgttttgat ttaaatgatg tttacgtata ttggcaaacc      180

agtgagtcga aaaccgtggt gacctaccac atcccacagc acagctcctt ggaaaacgtg      240

gacagccgct accggaaccg agccctgatg tcaccggccg gcatgctgcg gggcgacttc      300

tccctgcgct tgttcaacgt caccccccag gacgagcaga agtttcactg cctggtgttg      360

agcagatccc tgggattcca ggaggttttg agcgttgagg ttacactgca tgtggcagca      420

aacttcagcg tgggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcatta      480

ttcacagtga ctgttccgaa agagttgtat ataatcgagc aagggagtaa tgttaccctg      540

gaatgcaatt ttgacaccgg gtcacacgtc aacctcggag cgattactgc ttctttgcaa      600

aaagttgaaa acgacgcgtc cccccatagg gaaagggcga cccttctgga ggagcagttg      660

ccccttggca gggcactctt tcacattccc caggtgcaag tcagggacga ggggcaatac      720

cgctgcatca taatttacgg ggacgcgtgg gactacaagt acttgactct caaagttaaa      780

gctgattaca aggatgacga cgataagcac catcatcacc atcactag                   828


<210>  2585
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL 2266 - PD-L2 1417

<400>  2585

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Phe Thr Val Thr Val Pro 
    130                 135                 140                 


Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser Asn Val Thr Leu Glu Cys 
145                 150                 155                 160 


Asn Phe Asp Thr Gly Ser His Val Asn Leu Gly Ala Ile Thr Ala Ser 
                165                 170                 175     


Leu Gln Lys Val Glu Asn Asp Ala Ser Pro His Arg Glu Arg Ala Thr 
            180                 185                 190         


Leu Leu Glu Glu Gln Leu Pro Leu Gly Arg Ala Leu Phe His Ile Pro 
        195                 200                 205             


Gln Val Gln Val Arg Asp Glu Gly Gln Tyr Arg Cys Ile Ile Ile Tyr 
    210                 215                 220                 


Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr Leu Lys Val Lys Ala Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250             


<210>  2586
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - ICOSL 2264

<400>  2586
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttat tcacagtgac tgttccgaaa gagttgtata taatcgagca agggagtaat      120

gttaccctgg aatgcaattt tgacaccggg tcacacgtca acctcggagc gattactgct      180

tctttgcaaa aagttgaaaa cgacgcgtcc ccccataggg aaagggcgac ccttctggag      240

gagcagttgc cccttggcag ggcactcttt cacattcccc aggtgcaagt cagggacgag      300

gggcaatacc gctgcatcat aatttacggg gacgcgtggg actacaagta cttgactctc      360

aaagttaaag ctggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcagat      420

actcaggaga aggaagtcag agcgatggta ggcagcgacg tggagctcag ctgcgcttgc      480

cctgaaggaa gccgttttga tttaaatgat gtttacgtat attggcaaac cagtgagtcg      540

aaaaccgtgg tgacctacca catcccacag cacagctcct tggaatatgt ggacagccgc      600

taccggaacc gagccctgat gtcaccggcc ggcatgctgc ggggcgactt ctccctgcgc      660

ttgttcaacg tcacccccca ggacgagcag aagtttcact gcctggtgtt gagcagatcc      720

ctgggattcc aggaggtttt gagcgttgag gttacactgc atgtggcagc aaacttcagc      780

gtggattaca aggatgacga cgataagcac catcatcacc atcactag                   828


<210>  2587
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - ICOSL 2264

<400>  2587

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val 
        115                 120                 125             


Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe 
    130                 135                 140                 


Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr 
145                 150                 155                 160 


Val Val Thr Tyr His Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp 
                165                 170                 175     


Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg 
            180                 185                 190         


Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln 
        195                 200                 205             


Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val 
    210                 215                 220                 


Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250             


<210>  2588
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOSL 2264 - PD-L2 1417

<400>  2588
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgata ctcaggagaa ggaagtcaga gcgatggtag gcagcgacgt ggagctcagc      120

tgcgcttgcc ctgaaggaag ccgttttgat ttaaatgatg tttacgtata ttggcaaacc      180

agtgagtcga aaaccgtggt gacctaccac atcccacagc acagctcctt ggaatatgtg      240

gacagccgct accggaaccg agccctgatg tcaccggccg gcatgctgcg gggcgacttc      300

tccctgcgct tgttcaacgt caccccccag gacgagcaga agtttcactg cctggtgttg      360

agcagatccc tgggattcca ggaggttttg agcgttgagg ttacactgca tgtggcagca      420

aacttcagcg tgggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcatta      480

ttcacagtga ctgttccgaa agagttgtat ataatcgagc aagggagtaa tgttaccctg      540

gaatgcaatt ttgacaccgg gtcacacgtc aacctcggag cgattactgc ttctttgcaa      600

aaagttgaaa acgacgcgtc cccccatagg gaaagggcga cccttctgga ggagcagttg      660

ccccttggca gggcactctt tcacattccc caggtgcaag tcagggacga ggggcaatac      720

cgctgcatca taatttacgg ggacgcgtgg gactacaagt acttgactct caaagttaaa      780

gctgattaca aggatgacga cgataagcac catcatcacc atcactag                   828


<210>  2589
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL 2264 - PD-L2 1417

<400>  2589

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Phe Thr Val Thr Val Pro 
    130                 135                 140                 


Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser Asn Val Thr Leu Glu Cys 
145                 150                 155                 160 


Asn Phe Asp Thr Gly Ser His Val Asn Leu Gly Ala Ile Thr Ala Ser 
                165                 170                 175     


Leu Gln Lys Val Glu Asn Asp Ala Ser Pro His Arg Glu Arg Ala Thr 
            180                 185                 190         


Leu Leu Glu Glu Gln Leu Pro Leu Gly Arg Ala Leu Phe His Ile Pro 
        195                 200                 205             


Gln Val Gln Val Arg Asp Glu Gly Gln Tyr Arg Cys Ile Ile Ile Tyr 
    210                 215                 220                 


Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr Leu Lys Val Lys Ala Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250             


<210>  2590
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - ICOSL 2244

<400>  2590
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttat tcacagtgac tgttccgaaa gagttgtata taatcgagca agggagtaat      120

gttaccctgg aatgcaattt tgacaccggg tcacacgtca acctcggagc gattactgct      180

tctttgcaaa aagttgaaaa cgacgcgtcc ccccataggg aaagggcgac ccttctggag      240

gagcagttgc cccttggcag ggcactcttt cacattcccc aggtgcaagt cagggacgag      300

gggcaatacc gctgcatcat aatttacggg gacgcgtggg actacaagta cttgactctc      360

aaagttaaag ctggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcagat      420

actcaggaga aggaagtcag agcgatggta ggcagcgacg tggagctcag ctgcgcttgc      480

cctgaaggaa gccgttttga tttaaatgat gtttacgtat attggcaaac cagtgagtcg      540

aaaaccgtgg tgacctacca catcccacag aacagctcct tggaaaacgt ggacagccgc      600

taccggaacc gagccctgat gtcaccggcc ggcatgctgc ggggcgactt ctccctgcgc      660

ttgttcaacg tcacccccca ggacgagcag aagtttcact gcctggtgtt gagccaatcc      720

ctgggattcc aggaggtttt gagcgttgag gttacactgc atgtggcagc aaacttcagc      780

gtggattaca aggatgacga cgataagcac catcatcacc atcactag                   828


<210>  2591
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - ICOSL 2244

<400>  2591

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val 
        115                 120                 125             


Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe 
    130                 135                 140                 


Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr 
145                 150                 155                 160 


Val Val Thr Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp 
                165                 170                 175     


Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg 
            180                 185                 190         


Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln 
        195                 200                 205             


Lys Phe His Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val 
    210                 215                 220                 


Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250             


<210>  2592
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOSL 2244 - PD-L2 1417

<400>  2592
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgata ctcaggagaa ggaagtcaga gcgatggtag gcagcgacgt ggagctcagc      120

tgcgcttgcc ctgaaggaag ccgttttgat ttaaatgatg tttacgtata ttggcaaacc      180

agtgagtcga aaaccgtggt gacctaccac atcccacaga acagctcctt ggaaaacgtg      240

gacagccgct accggaaccg agccctgatg tcaccggccg gcatgctgcg gggcgacttc      300

tccctgcgct tgttcaacgt caccccccag gacgagcaga agtttcactg cctggtgttg      360

agccaatccc tgggattcca ggaggttttg agcgttgagg ttacactgca tgtggcagca      420

aacttcagcg tgggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcatta      480

ttcacagtga ctgttccgaa agagttgtat ataatcgagc aagggagtaa tgttaccctg      540

gaatgcaatt ttgacaccgg gtcacacgtc aacctcggag cgattactgc ttctttgcaa      600

aaagttgaaa acgacgcgtc cccccatagg gaaagggcga cccttctgga ggagcagttg      660

ccccttggca gggcactctt tcacattccc caggtgcaag tcagggacga ggggcaatac      720

cgctgcatca taatttacgg ggacgcgtgg gactacaagt acttgactct caaagttaaa      780

gctgattaca aggatgacga cgataagcac catcatcacc atcactag                   828


<210>  2593
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL 2244 - PD-L2 1417

<400>  2593

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Phe Thr Val Thr Val Pro 
    130                 135                 140                 


Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser Asn Val Thr Leu Glu Cys 
145                 150                 155                 160 


Asn Phe Asp Thr Gly Ser His Val Asn Leu Gly Ala Ile Thr Ala Ser 
                165                 170                 175     


Leu Gln Lys Val Glu Asn Asp Ala Ser Pro His Arg Glu Arg Ala Thr 
            180                 185                 190         


Leu Leu Glu Glu Gln Leu Pro Leu Gly Arg Ala Leu Phe His Ile Pro 
        195                 200                 205             


Gln Val Gln Val Arg Asp Glu Gly Gln Tyr Arg Cys Ile Ile Ile Tyr 
    210                 215                 220                 


Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr Leu Lys Val Lys Ala Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250             


<210>  2594
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - ICOSL 2247

<400>  2594
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttta ccgtaacggt ccctaaggat ttgtacgtgg ttgagtacgg gagcaatatg      120

acgattgaat gcaagttccc cgtagagaag cagctcgatt tggccgcttt gatagtgtac      180

tgggaaatgg aaggaaaaga catcattcaa ttcgtccacg gtgaagagga tcaaaaagcg      240

caacatagct cctatagaca acgcgcacgc ttgcttaaag accagctgag tcttggtaac      300

gcggcgctgc agattaccga cgtaaaactt caagacgcgg gagtttatcg ctgcatgatt      360

tcctacgggg gtggcgcaga ctataaaagg atcactgtaa aggtaaacgc cggatccgga      420

gggtctgggg gaggcggttc tgggggtgga ggctcagata ctcaggagaa ggaagtcaga      480

gcgatggtag gcagcgacgt ggagctcagc tgcgcttgcc ctgaaggaag ccgttttgat      540

ttaaatgatg tttacgtata ttggcaaacc agtgagtcga aaaccgtggt gacctaccac      600

atcccacagg acagctcctt ggaaaacgtg gacagccgct accggaaccg agccctgatg      660

tcaccggccg gcatgctgcg gggcgacttc tccctgcgct tgttcaacgt caccccccag      720

gacgagcaga agtttcactg cctggtgttg agccaatccc tgggattcca ggaggttttg      780

agcgttgagg ttacactgca tgtggcagca aacttcagcg tggattacaa ggatgacgac      840

gataagcacc atcatcacca tcactag                                          867


<210>  2595
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - ICOSL 2247

<400>  2595

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
    130                 135                 140                 


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
145                 150                 155                 160 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
                165                 170                 175     


Tyr His Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
            180                 185                 190         


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
        195                 200                 205             


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
    210                 215                 220                 


Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
225                 230                 235                 240 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Asp Tyr Lys Asp 
                245                 250                 255     


Asp Asp Asp Lys His His His His His His 
            260                 265     


<210>  2596
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOSL 2247 - PD-L1 303

<400>  2596
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgata ctcaggagaa ggaagtcaga gcgatggtag gcagcgacgt ggagctcagc      120

tgcgcttgcc ctgaaggaag ccgttttgat ttaaatgatg tttacgtata ttggcaaacc      180

agtgagtcga aaaccgtggt gacctaccac atcccacagg acagctcctt ggaaaacgtg      240

gacagccgct accggaaccg agccctgatg tcaccggccg gcatgctgcg gggcgacttc      300

tccctgcgct tgttcaacgt caccccccag gacgagcaga agtttcactg cctggtgttg      360

agccaatccc tgggattcca ggaggttttg agcgttgagg ttacactgca tgtggcagca      420

aacttcagcg tgggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcattt      480

accgtaacgg tccctaagga tttgtacgtg gttgagtacg ggagcaatat gacgattgaa      540

tgcaagttcc ccgtagagaa gcagctcgat ttggccgctt tgatagtgta ctgggaaatg      600

gaaggaaaag acatcattca attcgtccac ggtgaagagg atcaaaaagc gcaacatagc      660

tcctatagac aacgcgcacg cttgcttaaa gaccagctga gtcttggtaa cgcggcgctg      720

cagattaccg acgtaaaact tcaagacgcg ggagtttatc gctgcatgat ttcctacggg      780

ggtggcgcag actataaaag gatcactgta aaggtaaacg ccgattacaa ggatgacgac      840

gataagcacc atcatcacca tcactag                                          867


<210>  2597
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL 2247 - PD-L1 303

<400>  2597

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asp Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val Pro Lys 
    130                 135                 140                 


Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys 
145                 150                 155                 160 


Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp 
                165                 170                 175     


Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu Glu Asp 
            180                 185                 190         


Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys 
        195                 200                 205             


Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys 
    210                 215                 220                 


Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly 
225                 230                 235                 240 


Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Asp Tyr Lys Asp 
                245                 250                 255     


Asp Asp Asp Lys His His His His His His 
            260                 265     


<210>  2598
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - ICOSL 2266

<400>  2598
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttta ccgtaacggt ccctaaggat ttgtacgtgg ttgagtacgg gagcaatatg      120

acgattgaat gcaagttccc cgtagagaag cagctcgatt tggccgcttt gatagtgtac      180

tgggaaatgg aaggaaaaga catcattcaa ttcgtccacg gtgaagagga tcaaaaagcg      240

caacatagct cctatagaca acgcgcacgc ttgcttaaag accagctgag tcttggtaac      300

gcggcgctgc agattaccga cgtaaaactt caagacgcgg gagtttatcg ctgcatgatt      360

tcctacgggg gtggcgcaga ctataaaagg atcactgtaa aggtaaacgc cggatccgga      420

gggtctgggg gaggcggttc tgggggtgga ggctcagata ctcaggagaa ggaagtcaga      480

gcgatggtag gcagcgacgt ggagctcagc tgcgcttgcc ctgaaggaag ccgttttgat      540

ttaaatgatg tttacgtata ttggcaaacc agtgagtcga aaaccgtggt gacctaccac      600

atcccacagc acagctcctt ggaaaacgtg gacagccgct accggaaccg agccctgatg      660

tcaccggccg gcatgctgcg gggcgacttc tccctgcgct tgttcaacgt caccccccag      720

gacgagcaga agtttcactg cctggtgttg agcagatccc tgggattcca ggaggttttg      780

agcgttgagg ttacactgca tgtggcagca aacttcagcg tggattacaa ggatgacgac      840

gataagcacc atcatcacca tcactag                                          867


<210>  2599
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - ICOSL 2266

<400>  2599

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
    130                 135                 140                 


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
145                 150                 155                 160 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
                165                 170                 175     


Tyr His Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
            180                 185                 190         


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
        195                 200                 205             


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
    210                 215                 220                 


Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
225                 230                 235                 240 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Asp Tyr Lys Asp 
                245                 250                 255     


Asp Asp Asp Lys His His His His His His 
            260                 265     


<210>  2600
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOSL 2266 - PD-L1 303

<400>  2600
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgata ctcaggagaa ggaagtcaga gcgatggtag gcagcgacgt ggagctcagc      120

tgcgcttgcc ctgaaggaag ccgttttgat ttaaatgatg tttacgtata ttggcaaacc      180

agtgagtcga aaaccgtggt gacctaccac atcccacagc acagctcctt ggaaaacgtg      240

gacagccgct accggaaccg agccctgatg tcaccggccg gcatgctgcg gggcgacttc      300

tccctgcgct tgttcaacgt caccccccag gacgagcaga agtttcactg cctggtgttg      360

agcagatccc tgggattcca ggaggttttg agcgttgagg ttacactgca tgtggcagca      420

aacttcagcg tgggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcattt      480

accgtaacgg tccctaagga tttgtacgtg gttgagtacg ggagcaatat gacgattgaa      540

tgcaagttcc ccgtagagaa gcagctcgat ttggccgctt tgatagtgta ctgggaaatg      600

gaaggaaaag acatcattca attcgtccac ggtgaagagg atcaaaaagc gcaacatagc      660

tcctatagac aacgcgcacg cttgcttaaa gaccagctga gtcttggtaa cgcggcgctg      720

cagattaccg acgtaaaact tcaagacgcg ggagtttatc gctgcatgat ttcctacggg      780

ggtggcgcag actataaaag gatcactgta aaggtaaacg ccgattacaa ggatgacgac      840

gataagcacc atcatcacca tcactag                                          867


<210>  2601
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL 2266 - PD-L1 303

<400>  2601

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val Pro Lys 
    130                 135                 140                 


Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys 
145                 150                 155                 160 


Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp 
                165                 170                 175     


Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu Glu Asp 
            180                 185                 190         


Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys 
        195                 200                 205             


Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys 
    210                 215                 220                 


Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly 
225                 230                 235                 240 


Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Asp Tyr Lys Asp 
                245                 250                 255     


Asp Asp Asp Lys His His His His His His 
            260                 265     


<210>  2602
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - ICOSL 2264

<400>  2602
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttta ccgtaacggt ccctaaggat ttgtacgtgg ttgagtacgg gagcaatatg      120

acgattgaat gcaagttccc cgtagagaag cagctcgatt tggccgcttt gatagtgtac      180

tgggaaatgg aaggaaaaga catcattcaa ttcgtccacg gtgaagagga tcaaaaagcg      240

caacatagct cctatagaca acgcgcacgc ttgcttaaag accagctgag tcttggtaac      300

gcggcgctgc agattaccga cgtaaaactt caagacgcgg gagtttatcg ctgcatgatt      360

tcctacgggg gtggcgcaga ctataaaagg atcactgtaa aggtaaacgc cggatccgga      420

gggtctgggg gaggcggttc tgggggtgga ggctcagata ctcaggagaa ggaagtcaga      480

gcgatggtag gcagcgacgt ggagctcagc tgcgcttgcc ctgaaggaag ccgttttgat      540

ttaaatgatg tttacgtata ttggcaaacc agtgagtcga aaaccgtggt gacctaccac      600

atcccacagc acagctcctt ggaatatgtg gacagccgct accggaaccg agccctgatg      660

tcaccggccg gcatgctgcg gggcgacttc tccctgcgct tgttcaacgt caccccccag      720

gacgagcaga agtttcactg cctggtgttg agcagatccc tgggattcca ggaggttttg      780

agcgttgagg ttacactgca tgtggcagca aacttcagcg tggattacaa ggatgacgac      840

gataagcacc atcatcacca tcactag                                          867


<210>  2603
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - ICOSL 2264

<400>  2603

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
    130                 135                 140                 


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
145                 150                 155                 160 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
                165                 170                 175     


Tyr His Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr 
            180                 185                 190         


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
        195                 200                 205             


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
    210                 215                 220                 


Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
225                 230                 235                 240 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Asp Tyr Lys Asp 
                245                 250                 255     


Asp Asp Asp Lys His His His His His His 
            260                 265     


<210>  2604
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOSL 2264 - PD-L1 303

<400>  2604
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgata ctcaggagaa ggaagtcaga gcgatggtag gcagcgacgt ggagctcagc      120

tgcgcttgcc ctgaaggaag ccgttttgat ttaaatgatg tttacgtata ttggcaaacc      180

agtgagtcga aaaccgtggt gacctaccac atcccacagc acagctcctt ggaatatgtg      240

gacagccgct accggaaccg agccctgatg tcaccggccg gcatgctgcg gggcgacttc      300

tccctgcgct tgttcaacgt caccccccag gacgagcaga agtttcactg cctggtgttg      360

agcagatccc tgggattcca ggaggttttg agcgttgagg ttacactgca tgtggcagca      420

aacttcagcg tgggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcattt      480

accgtaacgg tccctaagga tttgtacgtg gttgagtacg ggagcaatat gacgattgaa      540

tgcaagttcc ccgtagagaa gcagctcgat ttggccgctt tgatagtgta ctgggaaatg      600

gaaggaaaag acatcattca attcgtccac ggtgaagagg atcaaaaagc gcaacatagc      660

tcctatagac aacgcgcacg cttgcttaaa gaccagctga gtcttggtaa cgcggcgctg      720

cagattaccg acgtaaaact tcaagacgcg ggagtttatc gctgcatgat ttcctacggg      780

ggtggcgcag actataaaag gatcactgta aaggtaaacg ccgattacaa ggatgacgac      840

gataagcacc atcatcacca tcactag                                          867


<210>  2605
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL 2264 - PD-L1 303

<400>  2605

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val Pro Lys 
    130                 135                 140                 


Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys 
145                 150                 155                 160 


Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp 
                165                 170                 175     


Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu Glu Asp 
            180                 185                 190         


Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys 
        195                 200                 205             


Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys 
    210                 215                 220                 


Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly 
225                 230                 235                 240 


Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Asp Tyr Lys Asp 
                245                 250                 255     


Asp Asp Asp Lys His His His His His His 
            260                 265     


<210>  2606
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - ICOSL 2244

<400>  2606
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttta ccgtaacggt ccctaaggat ttgtacgtgg ttgagtacgg gagcaatatg      120

acgattgaat gcaagttccc cgtagagaag cagctcgatt tggccgcttt gatagtgtac      180

tgggaaatgg aaggaaaaga catcattcaa ttcgtccacg gtgaagagga tcaaaaagcg      240

caacatagct cctatagaca acgcgcacgc ttgcttaaag accagctgag tcttggtaac      300

gcggcgctgc agattaccga cgtaaaactt caagacgcgg gagtttatcg ctgcatgatt      360

tcctacgggg gtggcgcaga ctataaaagg atcactgtaa aggtaaacgc cggatccgga      420

gggtctgggg gaggcggttc tgggggtgga ggctcagata ctcaggagaa ggaagtcaga      480

gcgatggtag gcagcgacgt ggagctcagc tgcgcttgcc ctgaaggaag ccgttttgat      540

ttaaatgatg tttacgtata ttggcaaacc agtgagtcga aaaccgtggt gacctaccac      600

atcccacaga acagctcctt ggaaaacgtg gacagccgct accggaaccg agccctgatg      660

tcaccggccg gcatgctgcg gggcgacttc tccctgcgct tgttcaacgt caccccccag      720

gacgagcaga agtttcactg cctggtgttg agccaatccc tgggattcca ggaggttttg      780

agcgttgagg ttacactgca tgtggcagca aacttcagcg tggattacaa ggatgacgac      840

gataagcacc atcatcacca tcactag                                          867


<210>  2607
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - ICOSL 2244

<400>  2607

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
    130                 135                 140                 


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
145                 150                 155                 160 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
                165                 170                 175     


Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
            180                 185                 190         


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
        195                 200                 205             


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
    210                 215                 220                 


Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
225                 230                 235                 240 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Asp Tyr Lys Asp 
                245                 250                 255     


Asp Asp Asp Lys His His His His His His 
            260                 265     


<210>  2608
<211>  867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOSL 2244 - PD-L1 303

<400>  2608
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgata ctcaggagaa ggaagtcaga gcgatggtag gcagcgacgt ggagctcagc      120

tgcgcttgcc ctgaaggaag ccgttttgat ttaaatgatg tttacgtata ttggcaaacc      180

agtgagtcga aaaccgtggt gacctaccac atcccacaga acagctcctt ggaaaacgtg      240

gacagccgct accggaaccg agccctgatg tcaccggccg gcatgctgcg gggcgacttc      300

tccctgcgct tgttcaacgt caccccccag gacgagcaga agtttcactg cctggtgttg      360

agccaatccc tgggattcca ggaggttttg agcgttgagg ttacactgca tgtggcagca      420

aacttcagcg tgggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcattt      480

accgtaacgg tccctaagga tttgtacgtg gttgagtacg ggagcaatat gacgattgaa      540

tgcaagttcc ccgtagagaa gcagctcgat ttggccgctt tgatagtgta ctgggaaatg      600

gaaggaaaag acatcattca attcgtccac ggtgaagagg atcaaaaagc gcaacatagc      660

tcctatagac aacgcgcacg cttgcttaaa gaccagctga gtcttggtaa cgcggcgctg      720

cagattaccg acgtaaaact tcaagacgcg ggagtttatc gctgcatgat ttcctacggg      780

ggtggcgcag actataaaag gatcactgta aaggtaaacg ccgattacaa ggatgacgac      840

gataagcacc atcatcacca tcactag                                          867


<210>  2609
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL 2244 - PD-L1 303

<400>  2609

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val Pro Lys 
    130                 135                 140                 


Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys 
145                 150                 155                 160 


Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp 
                165                 170                 175     


Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu Glu Asp 
            180                 185                 190         


Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys 
        195                 200                 205             


Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys 
    210                 215                 220                 


Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly 
225                 230                 235                 240 


Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Asp Tyr Lys Asp 
                245                 250                 255     


Asp Asp Asp Lys His His His His His His 
            260                 265     


<210>  2610
<211>  132
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Wildtype CD86 IgV

<400>  2610

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu 
    130         


<210>  2611
<211>  858
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - CD86 2610

<400>  2611
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttat tcacagtgac tgttccgaaa gagttgtata taatcgagca agggagtaat      120

gttaccctgg aatgcaattt tgacaccggg tcacacgtca acctcggagc gattactgct      180

tctttgcaaa aagttgaaaa cgacgcgtcc ccccataggg aaagggcgac ccttctggag      240

gagcagttgc cccttggcag ggcactcttt cacattcccc aggtgcaagt cagggacgag      300

gggcaatacc gctgcatcat aatttacggg gacgcgtggg actacaagta cttgactctc      360

aaagttaaag ctggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcagct      420

cctctgaaga ttcaagctta tttcaatgag actgcagacc tgccatgcca atttgcaaac      480

tctcaaaacc aaagcctgag tgagctagta gtattttggc aggaccagga aaacttggtt      540

ctgaatgagg tatacttagg caaagagaaa tttgacagtg ttcattccaa gtatatgggc      600

cgcacaagtt ttgattcgga cagttggacc ctgagacttc acaatcttca gatcaaggac      660

aagggcttgt atcaatgtat catccatcac aaaaagccca caggaatgat tcgcatccac      720

cagatgaatt ctgaactgtc agtgcttgct aacttcagtc aacctgaaat agtaccaatt      780

tctaatataa cagaaaatgt gtacataaat ttggattaca aggatgacga cgataagcac      840

catcatcacc atcactag                                                    858


<210>  2612
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - CD86 2610

<400>  2612

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu 
        115                 120                 125             


Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu 
    130                 135                 140                 


Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn 
145                 150                 155                 160 


Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr 
                165                 170                 175     


Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His 
            180                 185                 190         


Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His 
        195                 200                 205             


Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu 
    210                 215                 220                 


Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn 
225                 230                 235                 240 


Ile Thr Glu Asn Val Tyr Ile Asn Leu Asp Tyr Lys Asp Asp Asp Asp 
                245                 250                 255     


Lys His His His His His His 
            260             


<210>  2613
<211>  858
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD86 2610 - PD-L2 1417

<400>  2613
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgctc ctctgaagat tcaagcttat ttcaatgaga ctgcagacct gccatgccaa      120

tttgcaaact ctcaaaacca aagcctgagt gagctagtag tattttggca ggaccaggaa      180

aacttggttc tgaatgaggt atacttaggc aaagagaaat ttgacagtgt tcattccaag      240

tatatgggcc gcacaagttt tgattcggac agttggaccc tgagacttca caatcttcag      300

atcaaggaca agggcttgta tcaatgtatc atccatcaca aaaagcccac aggaatgatt      360

cgcatccacc agatgaattc tgaactgtca gtgcttgcta acttcagtca acctgaaata      420

gtaccaattt ctaatataac agaaaatgtg tacataaatt tgggatccgg agggtctggg      480

ggaggcggtt ctgggggtgg aggctcatta ttcacagtga ctgttccgaa agagttgtat      540

ataatcgagc aagggagtaa tgttaccctg gaatgcaatt ttgacaccgg gtcacacgtc      600

aacctcggag cgattactgc ttctttgcaa aaagttgaaa acgacgcgtc cccccatagg      660

gaaagggcga cccttctgga ggagcagttg ccccttggca gggcactctt tcacattccc      720

caggtgcaag tcagggacga ggggcaatac cgctgcatca taatttacgg ggacgcgtgg      780

gactacaagt acttgactct caaagttaaa gctgattaca aggatgacga cgataagcac      840

catcatcacc atcactag                                                    858


<210>  2614
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 2610 - PD-L2 1417

<400>  2614

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
145                 150                 155                 160 


Glu Gln Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
                165                 170                 175     


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
            180                 185                 190         


Asp Ala Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
        195                 200                 205             


Pro Leu Gly Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp 
    210                 215                 220                 


Glu Gly Gln Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr 
225                 230                 235                 240 


Lys Tyr Leu Thr Leu Lys Val Lys Ala Asp Tyr Lys Asp Asp Asp Asp 
                245                 250                 255     


Lys His His His His His 
            260         


<210>  2615
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Wildtype CD80 IgV

<400>  2615

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe 
            100                 105             


<210>  2616
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v165  IgV

<400>  2616

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val 
            100 


<210>  2617
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v191 IgV

<400>  2617

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Glu Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val 
            100 


<210>  2618
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - CD80 2615

<400>  2618
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttat tcacagtgac tgttccgaaa gagttgtata taatcgagca agggagtaat      120

gttaccctgg aatgcaattt tgacaccggg tcacacgtca acctcggagc gattactgct      180

tctttgcaaa aagttgaaaa cgacgcgtcc ccccataggg aaagggcgac ccttctggag      240

gagcagttgc cccttggcag ggcactcttt cacattcccc aggtgcaagt cagggacgag      300

gggcaatacc gctgcatcat aatttacggg gacgcgtggg actacaagta cttgactctc      360

aaagttaaag ctggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcagtt      420

atccacgtga ccaaggaagt gaaagaagtg gcaacgctgt cctgtggtca caatgtttct      480

gttgaagagc tggcacaaac tcgcatctac tggcaaaagg agaagaaaat ggtgctgact      540

atgatgtctg gggacatgaa tatatggccc gagtacaaga accggaccat ctttgacatc      600

actaataacc tctccattgt gatcctggct ctgcgcccat ctgacgaggg cacatacgag      660

tgtgttgttc tgaagtatga aaaagacgct ttcaagcggg aacacctggc tgaagtgacg      720

ttatcagtca aagctgactt cgattacaag gatgacgacg ataagcacca tcatcaccat      780

cactag                                                                 786


<210>  2619
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L2 1417 - CD80 2615

<400>  2619

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Val Ile His Val Thr Lys Glu Val Lys Glu Val 
        115                 120                 125             


Ala Thr Leu Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln 
    130                 135                 140                 


Thr Arg Ile Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met 
145                 150                 155                 160 


Ser Gly Asp Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe 
                165                 170                 175     


Asp Ile Thr Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser 
            180                 185                 190         


Asp Glu Gly Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala 
        195                 200                 205             


Phe Lys Arg Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
    210                 215                 220                 


Phe Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
225                 230                 235                 


<210>  2620
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD80 2615 - PD-L2 1417

<400>  2620
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgtta tccacgtgac caaggaagtg aaagaagtgg caacgctgtc ctgtggtcac      120

aatgtttctg ttgaagagct ggcacaaact cgcatctact ggcaaaagga gaagaaaatg      180

gtgctgacta tgatgtctgg ggacatgaat atatggcccg agtacaagaa ccggaccatc      240

tttgacatca ctaataacct ctccattgtg atcctggctc tgcgcccatc tgacgagggc      300

acatacgagt gtgttgttct gaagtatgaa aaagacgctt tcaagcggga acacctggct      360

gaagtgacgt tatcagtcaa agctgacttc ggatccggag ggtctggggg aggcggttct      420

gggggtggag gctcattatt cacagtgact gttccgaaag agttgtatat aatcgagcaa      480

gggagtaatg ttaccctgga atgcaatttt gacaccgggt cacacgtcaa cctcggagcg      540

attactgctt ctttgcaaaa agttgaaaac gacgcgtccc cccataggga aagggcgacc      600

cttctggagg agcagttgcc ccttggcagg gcactctttc acattcccca ggtgcaagtc      660

agggacgagg ggcaataccg ctgcatcata atttacgggg acgcgtggga ctacaagtac      720

ttgactctca aagttaaagc tgattacaag gatgacgacg ataagcacca tcatcaccat      780

cactag                                                                 786


<210>  2621
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 2615 - PD-L2 1417

<400>  2621

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Gly Ser Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Phe Thr Val Thr 
        115                 120                 125             


Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser Asn Val Thr Leu 
    130                 135                 140                 


Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu Gly Ala Ile Thr 
145                 150                 155                 160 


Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro His Arg Glu Arg 
                165                 170                 175     


Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Arg Ala Leu Phe His 
            180                 185                 190         


Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr Arg Cys Ile Ile 
        195                 200                 205             


Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr Leu Lys Val Lys 
    210                 215                 220                 


Ala Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
225                 230                 235                 


<210>  2622
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - CD80 2616

<400>  2622
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttat tcacagtgac tgttccgaaa gagttgtata taatcgagca agggagtaat      120

gttaccctgg aatgcaattt tgacaccggg tcacacgtca acctcggagc gattactgct      180

tctttgcaaa aagttgaaaa cgacgcgtcc ccccataggg aaagggcgac ccttctggag      240

gagcagttgc cccttggcag ggcactcttt cacattcccc aggtgcaagt cagggacgag      300

gggcaatacc gctgcatcat aatttacggg gacgcgtggg actacaagta cttgactctc      360

aaagttaaag ctggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcagtt      420

atccacgtga ccaaggaagt gaaagaagtg gcaacgctgt cctgtggtca caatgtttct      480

ctggaagagc tggcacaaac tcgcatctac tggcaaaagg gtaagaaaat ggtgctgact      540

atgatgtctg gggacatgaa tatatggccc gagtacaaga accggaccat ctttgacatc      600

actaataacc tctccattgt gatcctggac ccacgcccat ctgacgaggg cacatacgag      660

tgtgttgttc tgaagtatga aaaagacgct ttcaagcggg aacacctggc tgaagtggat      720

tacaaggatg acgacgataa gcaccatcat caccatcact ag                         762


<210>  2623
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - CD80 2616

<400>  2623

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Val Ile His Val Thr Lys Glu Val Lys Glu Val 
        115                 120                 125             


Ala Thr Leu Ser Cys Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln 
    130                 135                 140                 


Thr Arg Ile Tyr Trp Gln Lys Gly Lys Lys Met Val Leu Thr Met Met 
145                 150                 155                 160 


Ser Gly Asp Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe 
                165                 170                 175     


Asp Ile Thr Asn Asn Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser 
            180                 185                 190         


Asp Glu Gly Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala 
        195                 200                 205             


Phe Lys Arg Glu His Leu Ala Glu Val Asp Tyr Lys Asp Asp Asp Asp 
    210                 215                 220                 


Lys His His His His His His 
225                 230     


<210>  2624
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD80 2616 - PD-L2 1417

<400>  2624
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgtta tccacgtgac caaggaagtg aaagaagtgg caacgctgtc ctgtggtcac      120

aatgtttctc tggaagagct ggcacaaact cgcatctact ggcaaaaggg taagaaaatg      180

gtgctgacta tgatgtctgg ggacatgaat atatggcccg agtacaagaa ccggaccatc      240

tttgacatca ctaataacct ctccattgtg atcctggacc cacgcccatc tgacgagggc      300

acatacgagt gtgttgttct gaagtatgaa aaagacgctt tcaagcggga acacctggct      360

gaagtgggat ccggagggtc tgggggaggc ggttctgggg gtggaggctc attattcaca      420

gtgactgttc cgaaagagtt gtatataatc gagcaaggga gtaatgttac cctggaatgc      480

aattttgaca ccgggtcaca cgtcaacctc ggagcgatta ctgcttcttt gcaaaaagtt      540

gaaaacgacg cgtcccccca tagggaaagg gcgacccttc tggaggagca gttgcccctt      600

ggcagggcac tctttcacat tccccaggtg caagtcaggg acgaggggca ataccgctgc      660

atcataattt acggggacgc gtgggactac aagtacttga ctctcaaagt taaagctgat      720

tacaaggatg acgacgataa gcaccatcat caccatcact ag                         762


<210>  2625
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 2616 - PD-L2 1417

<400>  2625

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
        115                 120                 125             


Glu Gln Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
    130                 135                 140                 


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
145                 150                 155                 160 


Asp Ala Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
                165                 170                 175     


Pro Leu Gly Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp 
            180                 185                 190         


Glu Gly Gln Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr 
        195                 200                 205             


Lys Tyr Leu Thr Leu Lys Val Lys Ala Asp Tyr Lys Asp Asp Asp Asp 
    210                 215                 220                 


Lys His His His His His His 
225                 230     


<210>  2626
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - CD80 2617

<400>  2626
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttat tcacagtgac tgttccgaaa gagttgtata taatcgagca agggagtaat      120

gttaccctgg aatgcaattt tgacaccggg tcacacgtca acctcggagc gattactgct      180

tctttgcaaa aagttgaaaa cgacgcgtcc ccccataggg aaagggcgac ccttctggag      240

gagcagttgc cccttggcag ggcactcttt cacattcccc aggtgcaagt cagggacgag      300

gggcaatacc gctgcatcat aatttacggg gacgcgtggg actacaagta cttgactctc      360

aaagttaaag ctggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcagtt      420

atccacgtga ccaaggaagt gaaagaagtg gcaacgctgt cctgtggtca caatgtttct      480

gttgaagagc tggcacaaac tcgcatctac tggcaaaagg gtaagaaaat ggtgctgact      540

atgatgtctg gggacatgaa tatatggccc gagtacgaaa accggaccat ctttgacatc      600

actaataacc tctccattgt gatcctggac ccacgcccat ctgacgaggg cacatacgag      660

tgtgttgttc tgaagtatga aaaagacgct ttcaagcggg aacacctggc tgaagtggat      720

tacaaggatg acgacgataa gcaccatcat caccatcact ag                         762


<210>  2627
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - CD80 2617

<400>  2627

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Val Ile His Val Thr Lys Glu Val Lys Glu Val 
        115                 120                 125             


Ala Thr Leu Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln 
    130                 135                 140                 


Thr Arg Ile Tyr Trp Gln Lys Gly Lys Lys Met Val Leu Thr Met Met 
145                 150                 155                 160 


Ser Gly Asp Met Asn Ile Trp Pro Glu Tyr Glu Asn Arg Thr Ile Phe 
                165                 170                 175     


Asp Ile Thr Asn Asn Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser 
            180                 185                 190         


Asp Glu Gly Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala 
        195                 200                 205             


Phe Lys Arg Glu His Leu Ala Glu Val Asp Tyr Lys Asp Asp Asp Asp 
    210                 215                 220                 


Lys His His His His His His 
225                 230     


<210>  2628
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD80 2617 - PD-L2 1417

<400>  2628
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgtta tccacgtgac caaggaagtg aaagaagtgg caacgctgtc ctgtggtcac      120

aatgtttctg ttgaagagct ggcacaaact cgcatctact ggcaaaaggg taagaaaatg      180

gtgctgacta tgatgtctgg ggacatgaat atatggcccg agtacgaaaa ccggaccatc      240

tttgacatca ctaataacct ctccattgtg atcctggacc cacgcccatc tgacgagggc      300

acatacgagt gtgttgttct gaagtatgaa aaagacgctt tcaagcggga acacctggct      360

gaagtgggat ccggagggtc tgggggaggc ggttctgggg gtggaggctc attattcaca      420

gtgactgttc cgaaagagtt gtatataatc gagcaaggga gtaatgttac cctggaatgc      480

aattttgaca ccgggtcaca cgtcaacctc ggagcgatta ctgcttcttt gcaaaaagtt      540

gaaaacgacg cgtcccccca tagggaaagg gcgacccttc tggaggagca gttgcccctt      600

ggcagggcac tctttcacat tccccaggtg caagtcaggg acgaggggca ataccgctgc      660

atcataattt acggggacgc gtgggactac aagtacttga ctctcaaagt taaagctgat      720

tacaaggatg acgacgataa gcaccatcat caccatcact ag                         762


<210>  2629
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 2617 - PD-L2 1417

<400>  2629

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Glu Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
        115                 120                 125             


Glu Gln Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
    130                 135                 140                 


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
145                 150                 155                 160 


Asp Ala Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
                165                 170                 175     


Pro Leu Gly Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp 
            180                 185                 190         


Glu Gly Gln Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr 
        195                 200                 205             


Lys Tyr Leu Thr Leu Lys Val Lys Ala Asp Tyr Lys Asp Asp Asp Asp 
    210                 215                 220                 


Lys His His His His His His 
225                 230     


<210>  2630
<211>  897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - CD86 2610

<400>  2630
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttta ccgtaacggt ccctaaggat ttgtacgtgg ttgagtacgg gagcaatatg      120

acgattgaat gcaagttccc cgtagagaag cagctcgatt tggccgcttt gatagtgtac      180

tgggaaatgg aaggaaaaga catcattcaa ttcgtccacg gtgaagagga tcaaaaagcg      240

caacatagct cctatagaca acgcgcacgc ttgcttaaag accagctgag tcttggtaac      300

gcggcgctgc agattaccga cgtaaaactt caagacgcgg gagtttatcg ctgcatgatt      360

tcctacgggg gtggcgcaga ctataaaagg atcactgtaa aggtaaacgc cggatccgga      420

gggtctgggg gaggcggttc tgggggtgga ggctcagctc ctctgaagat tcaagcttat      480

ttcaatgaga ctgcagacct gccatgccaa tttgcaaact ctcaaaacca aagcctgagt      540

gagctagtag tattttggca ggaccaggaa aacttggttc tgaatgaggt atacttaggc      600

aaagagaaat ttgacagtgt tcattccaag tatatgggcc gcacaagttt tgattcggac      660

agttggaccc tgagacttca caatcttcag atcaaggaca agggcttgta tcaatgtatc      720

atccatcaca aaaagcccac aggaatgatt cgcatccacc agatgaattc tgaactgtca      780

gtgcttgcta acttcagtca acctgaaata gtaccaattt ctaatataac agaaaatgtg      840

tacataaatt tggattacaa ggatgacgac gataagcacc atcatcacca tcactag         897


<210>  2631
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - CD86 2610

<400>  2631

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp 
    130                 135                 140                 


Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu 
145                 150                 155                 160 


Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr 
                165                 170                 175     


Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg 
            180                 185                 190         


Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln 
        195                 200                 205             


Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro 
    210                 215                 220                 


Thr Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu 
225                 230                 235                 240 


Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu 
                245                 250                 255     


Asn Val Tyr Ile Asn Leu Asp Tyr Lys Asp Asp Asp Asp Lys His His 
            260                 265                 270         


His His His His 
        275     


<210>  2632
<211>  897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD86 2610 - PD-L1 303

<400>  2632
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgctc ctctgaagat tcaagcttat ttcaatgaga ctgcagacct gccatgccaa      120

tttgcaaact ctcaaaacca aagcctgagt gagctagtag tattttggca ggaccaggaa      180

aacttggttc tgaatgaggt atacttaggc aaagagaaat ttgacagtgt tcattccaag      240

tatatgggcc gcacaagttt tgattcggac agttggaccc tgagacttca caatcttcag      300

atcaaggaca agggcttgta tcaatgtatc atccatcaca aaaagcccac aggaatgatt      360

cgcatccacc agatgaattc tgaactgtca gtgcttgcta acttcagtca acctgaaata      420

gtaccaattt ctaatataac agaaaatgtg tacataaatt tgggatccgg agggtctggg      480

ggaggcggtt ctgggggtgg aggctcattt accgtaacgg tccctaagga tttgtacgtg      540

gttgagtacg ggagcaatat gacgattgaa tgcaagttcc ccgtagagaa gcagctcgat      600

ttggccgctt tgatagtgta ctgggaaatg gaaggaaaag acatcattca attcgtccac      660

ggtgaagagg atcaaaaagc gcaacatagc tcctatagac aacgcgcacg cttgcttaaa      720

gaccagctga gtcttggtaa cgcggcgctg cagattaccg acgtaaaact tcaagacgcg      780

ggagtttatc gctgcatgat ttcctacggg ggtggcgcag actataaaag gatcactgta      840

aaggtaaacg ccgattacaa ggatgacgac gataagcacc atcatcacca tcactag         897


<210>  2633
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 2610 - PD-L1 303

<400>  2633

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu 
145                 150                 155                 160 


Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln 
                165                 170                 175     


Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp 
            180                 185                 190         


Ile Ile Gln Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser 
        195                 200                 205             


Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly 
    210                 215                 220                 


Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val 
225                 230                 235                 240 


Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile 
                245                 250                 255     


Thr Val Lys Val Asn Ala Asp Tyr Lys Asp Asp Asp Asp Lys His His 
            260                 265                 270         


His His His His 
        275     


<210>  2634
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 303  - CD80 2615

<400>  2634
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttta ccgtaacggt ccctaaggat ttgtacgtgg ttgagtacgg gagcaatatg      120

acgattgaat gcaagttccc cgtagagaag cagctcgatt tggccgcttt gatagtgtac      180

tgggaaatgg aaggaaaaga catcattcaa ttcgtccacg gtgaagagga tcaaaaagcg      240

caacatagct cctatagaca acgcgcacgc ttgcttaaag accagctgag tcttggtaac      300

gcggcgctgc agattaccga cgtaaaactt caagacgcgg gagtttatcg ctgcatgatt      360

tcctacgggg gtggcgcaga ctataaaagg atcactgtaa aggtaaacgc cggatccgga      420

gggtctgggg gaggcggttc tgggggtgga ggctcagtta tccacgtgac caaggaagtg      480

aaagaagtgg caacgctgtc ctgtggtcac aatgtttctg ttgaagagct ggcacaaact      540

cgcatctact ggcaaaagga gaagaaaatg gtgctgacta tgatgtctgg ggacatgaat      600

atatggcccg agtacaagaa ccggaccatc tttgacatca ctaataacct ctccattgtg      660

atcctggctc tgcgcccatc tgacgagggc acatacgagt gtgttgttct gaagtatgaa      720

aaagacgctt tcaagcggga acacctggct gaagtgacgt tatcagtcaa agctgacttc      780

gattacaagg atgacgacga taagcaccat catcaccatc actag                      825


<210>  2635
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303  - CD80 2615

<400>  2635

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
    130                 135                 140                 


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
145                 150                 155                 160 


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
                165                 170                 175     


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
            180                 185                 190         


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
        195                 200                 205             


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
    210                 215                 220                 


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Asp Tyr 
225                 230                 235                 240 


Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250         


<210>  2636
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD80 2615 - PD-L1 303

<400>  2636
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgtta tccacgtgac caaggaagtg aaagaagtgg caacgctgtc ctgtggtcac      120

aatgtttctg ttgaagagct ggcacaaact cgcatctact ggcaaaagga gaagaaaatg      180

gtgctgacta tgatgtctgg ggacatgaat atatggcccg agtacaagaa ccggaccatc      240

tttgacatca ctaataacct ctccattgtg atcctggctc tgcgcccatc tgacgagggc      300

acatacgagt gtgttgttct gaagtatgaa aaagacgctt tcaagcggga acacctggct      360

gaagtgacgt tatcagtcaa agctgacttc ggatccggag ggtctggggg aggcggttct      420

gggggtggag gctcatttac cgtaacggtc cctaaggatt tgtacgtggt tgagtacggg      480

agcaatatga cgattgaatg caagttcccc gtagagaagc agctcgattt ggccgctttg      540

atagtgtact gggaaatgga aggaaaagac atcattcaat tcgtccacgg tgaagaggat      600

caaaaagcgc aacatagctc ctatagacaa cgcgcacgct tgcttaaaga ccagctgagt      660

cttggtaacg cggcgctgca gattaccgac gtaaaacttc aagacgcggg agtttatcgc      720

tgcatgattt cctacggggg tggcgcagac tataaaagga tcactgtaaa ggtaaacgcc      780

gattacaagg atgacgacga taagcaccat catcaccatc actag                      825


<210>  2637
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 2615 - PD-L1 303

<400>  2637

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Gly Ser Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val 
        115                 120                 125             


Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
    130                 135                 140                 


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
145                 150                 155                 160 


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
                165                 170                 175     


Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
            180                 185                 190         


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
        195                 200                 205             


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
    210                 215                 220                 


Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Asp Tyr 
225                 230                 235                 240 


Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250         


<210>  2638
<211>  801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - CD80 2616

<400>  2638
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttta ccgtaacggt ccctaaggat ttgtacgtgg ttgagtacgg gagcaatatg      120

acgattgaat gcaagttccc cgtagagaag cagctcgatt tggccgcttt gatagtgtac      180

tgggaaatgg aaggaaaaga catcattcaa ttcgtccacg gtgaagagga tcaaaaagcg      240

caacatagct cctatagaca acgcgcacgc ttgcttaaag accagctgag tcttggtaac      300

gcggcgctgc agattaccga cgtaaaactt caagacgcgg gagtttatcg ctgcatgatt      360

tcctacgggg gtggcgcaga ctataaaagg atcactgtaa aggtaaacgc cggatccgga      420

gggtctgggg gaggcggttc tgggggtgga ggctcagtta tccacgtgac caaggaagtg      480

aaagaagtgg caacgctgtc ctgtggtcac aatgtttctc tggaagagct ggcacaaact      540

cgcatctact ggcaaaaggg taagaaaatg gtgctgacta tgatgtctgg ggacatgaat      600

atatggcccg agtacaagaa ccggaccatc tttgacatca ctaataacct ctccattgtg      660

atcctggacc cacgcccatc tgacgagggc acatacgagt gtgttgttct gaagtatgaa      720

aaagacgctt tcaagcggga acacctggct gaagtggatt acaaggatga cgacgataag      780

caccatcatc accatcacta g                                                801


<210>  2639
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - CD80 2616

<400>  2639

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
    130                 135                 140                 


Ser Cys Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile 
145                 150                 155                 160 


Tyr Trp Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
                165                 170                 175     


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
            180                 185                 190         


Asn Asn Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly 
        195                 200                 205             


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
    210                 215                 220                 


Glu His Leu Ala Glu Val Asp Tyr Lys Asp Asp Asp Asp Lys His His 
225                 230                 235                 240 


His His His His 
                


<210>  2640
<211>  801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD80 2616 - PD-L1 303

<400>  2640
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgtta tccacgtgac caaggaagtg aaagaagtgg caacgctgtc ctgtggtcac      120

aatgtttctc tggaagagct ggcacaaact cgcatctact ggcaaaaggg taagaaaatg      180

gtgctgacta tgatgtctgg ggacatgaat atatggcccg agtacaagaa ccggaccatc      240

tttgacatca ctaataacct ctccattgtg atcctggacc cacgcccatc tgacgagggc      300

acatacgagt gtgttgttct gaagtatgaa aaagacgctt tcaagcggga acacctggct      360

gaagtgggat ccggagggtc tgggggaggc ggttctgggg gtggaggctc atttaccgta      420

acggtcccta aggatttgta cgtggttgag tacgggagca atatgacgat tgaatgcaag      480

ttccccgtag agaagcagct cgatttggcc gctttgatag tgtactggga aatggaagga      540

aaagacatca ttcaattcgt ccacggtgaa gaggatcaaa aagcgcaaca tagctcctat      600

agacaacgcg cacgcttgct taaagaccag ctgagtcttg gtaacgcggc gctgcagatt      660

accgacgtaa aacttcaaga cgcgggagtt tatcgctgca tgatttccta cgggggtggc      720

gcagactata aaaggatcac tgtaaaggta aacgccgatt acaaggatga cgacgataag      780

caccatcatc accatcacta g                                                801


<210>  2641
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 2616 - PD-L1 303

<400>  2641

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu 
        115                 120                 125             


Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln 
    130                 135                 140                 


Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp 
145                 150                 155                 160 


Ile Ile Gln Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser 
                165                 170                 175     


Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly 
            180                 185                 190         


Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val 
        195                 200                 205             


Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile 
    210                 215                 220                 


Thr Val Lys Val Asn Ala Asp Tyr Lys Asp Asp Asp Asp Lys His His 
225                 230                 235                 240 


His His His His 
                


<210>  2642
<211>  801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - CD80 2617

<400>  2642
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttta ccgtaacggt ccctaaggat ttgtacgtgg ttgagtacgg gagcaatatg      120

acgattgaat gcaagttccc cgtagagaag cagctcgatt tggccgcttt gatagtgtac      180

tgggaaatgg aaggaaaaga catcattcaa ttcgtccacg gtgaagagga tcaaaaagcg      240

caacatagct cctatagaca acgcgcacgc ttgcttaaag accagctgag tcttggtaac      300

gcggcgctgc agattaccga cgtaaaactt caagacgcgg gagtttatcg ctgcatgatt      360

tcctacgggg gtggcgcaga ctataaaagg atcactgtaa aggtaaacgc cggatccgga      420

gggtctgggg gaggcggttc tgggggtgga ggctcagtta tccacgtgac caaggaagtg      480

aaagaagtgg caacgctgtc ctgtggtcac aatgtttctg ttgaagagct ggcacaaact      540

cgcatctact ggcaaaaggg taagaaaatg gtgctgacta tgatgtctgg ggacatgaat      600

atatggcccg agtacgaaaa ccggaccatc tttgacatca ctaataacct ctccattgtg      660

atcctggacc cacgcccatc tgacgagggc acatacgagt gtgttgttct gaagtatgaa      720

aaagacgctt tcaagcggga acacctggct gaagtggatt acaaggatga cgacgataag      780

caccatcatc accatcacta g                                                801


<210>  2643
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - CD80 2617

<400>  2643

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
    130                 135                 140                 


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
145                 150                 155                 160 


Tyr Trp Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
                165                 170                 175     


Met Asn Ile Trp Pro Glu Tyr Glu Asn Arg Thr Ile Phe Asp Ile Thr 
            180                 185                 190         


Asn Asn Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly 
        195                 200                 205             


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
    210                 215                 220                 


Glu His Leu Ala Glu Val Asp Tyr Lys Asp Asp Asp Asp Lys His His 
225                 230                 235                 240 


His His His His 
                


<210>  2644
<211>  801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD80 2617 - PD-L1 303

<400>  2644
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctgtta tccacgtgac caaggaagtg aaagaagtgg caacgctgtc ctgtggtcac      120

aatgtttctg ttgaagagct ggcacaaact cgcatctact ggcaaaaggg taagaaaatg      180

gtgctgacta tgatgtctgg ggacatgaat atatggcccg agtacgaaaa ccggaccatc      240

tttgacatca ctaataacct ctccattgtg atcctggacc cacgcccatc tgacgagggc      300

acatacgagt gtgttgttct gaagtatgaa aaagacgctt tcaagcggga acacctggct      360

gaagtgggat ccggagggtc tgggggaggc ggttctgggg gtggaggctc atttaccgta      420

acggtcccta aggatttgta cgtggttgag tacgggagca atatgacgat tgaatgcaag      480

ttccccgtag agaagcagct cgatttggcc gctttgatag tgtactggga aatggaagga      540

aaagacatca ttcaattcgt ccacggtgaa gaggatcaaa aagcgcaaca tagctcctat      600

agacaacgcg cacgcttgct taaagaccag ctgagtcttg gtaacgcggc gctgcagatt      660

accgacgtaa aacttcaaga cgcgggagtt tatcgctgca tgatttccta cgggggtggc      720

gcagactata aaaggatcac tgtaaaggta aacgccgatt acaaggatga cgacgataag      780

caccatcatc accatcacta g                                                801


<210>  2645
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 2617 - PD-L1 303

<400>  2645

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Glu Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu 
        115                 120                 125             


Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln 
    130                 135                 140                 


Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp 
145                 150                 155                 160 


Ile Ile Gln Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser 
                165                 170                 175     


Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly 
            180                 185                 190         


Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val 
        195                 200                 205             


Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile 
    210                 215                 220                 


Thr Val Lys Val Asn Ala Asp Tyr Lys Asp Asp Asp Asp Lys His His 
225                 230                 235                 240 


His His His His 
                


<210>  2646
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA-4 2520 - PD-L1 303

<400>  2646
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctaag       60

gcgatgcacg tagcccagcc cgctgttgtt ctcgcaagtt ctcgcggcat agcctccttc      120

gtatgtgagt atgccagtcc aggtaagtac acggaggtac gggtaactgt actgcggcag      180

gccgattccc aggttacgga ggtttgtgcg gcaacctaca tgatgggtaa cgagcttaca      240

tttctcgacg actcaatatg tactgggacc tcctcaggaa atcaggtcaa tctgaccatc      300

caaggtctga gggcgatgga tacgggtctt tatatttgca aggttgaact catgtatccg      360

cctccatact atgaaggcat tggaaatgga acacaaatct atgttattga cccggagccg      420

tctccagata gtgatcaggg atccggaggg tctgggggag gcggttctgg gggtggaggc      480

tcatttaccg taacggtccc taaggatttg tacgtggttg agtacgggag caatatgacg      540

attgaatgca agttccccgt agagaagcag ctcgatttgg ccgctttgat agtgtactgg      600

gaaatggaag gaaaagacat cattcaattc gtccacggtg aagaggatca aaaagcgcaa      660

catagctcct atagacaacg cgcacgcttg cttaaagacc agctgagtct tggtaacgcg      720

gcgctgcaga ttaccgacgt aaaacttcaa gacgcgggag tttatcgctg catgatttcc      780

tacgggggtg gcgcagacta taaaaggatc actgtaaagg taaacgccga ttacaaggat      840

gacgacgata agcaccatca tcaccatcac tag                                   873


<210>  2647
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 2520 - PD-L1 303

<400>  2647

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp Gln Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr 
    130                 135                 140                 


Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met 
145                 150                 155                 160 


Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala 
                165                 170                 175     


Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val 
            180                 185                 190         


His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg 
        195                 200                 205             


Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln 
    210                 215                 220                 


Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile 
225                 230                 235                 240 


Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn 
                245                 250                 255     


Ala Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
            260                 265                 270     


<210>  2648
<211>  834
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA-4 2520 - PD-L2 1417

<400>  2648
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctaag       60

gcgatgcacg tagcccagcc cgctgttgtt ctcgcaagtt ctcgcggcat agcctccttc      120

gtatgtgagt atgccagtcc aggtaagtac acggaggtac gggtaactgt actgcggcag      180

gccgattccc aggttacgga ggtttgtgcg gcaacctaca tgatgggtaa cgagcttaca      240

tttctcgacg actcaatatg tactgggacc tcctcaggaa atcaggtcaa tctgaccatc      300

caaggtctga gggcgatgga tacgggtctt tatatttgca aggttgaact catgtatccg      360

cctccatact atgaaggcat tggaaatgga acacaaatct atgttattga cccggagccg      420

tctccagata gtgatcaggg atccggaggg tctgggggag gcggttctgg gggtggaggc      480

tcattattca cagtgactgt tccgaaagag ttgtatataa tcgagcaagg gagtaatgtt      540

accctggaat gcaattttga caccgggtca cacgtcaacc tcggagcgat tactgcttct      600

ttgcaaaaag ttgaaaacga cgcgtccccc catagggaaa gggcgaccct tctggaggag      660

cagttgcccc ttggcagggc actctttcac attccccagg tgcaagtcag ggacgagggg      720

caataccgct gcatcataat ttacggggac gcgtgggact acaagtactt gactctcaaa      780

gttaaagctg attacaagga tgacgacgat aagcaccatc atcaccatca ctag            834


<210>  2649
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 2520 - PD-L2 1417

<400>  2649

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp Gln Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Phe 
    130                 135                 140                 


Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser Asn 
145                 150                 155                 160 


Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu Gly 
                165                 170                 175     


Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro His 
            180                 185                 190         


Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Arg Ala 
        195                 200                 205             


Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr Arg 
    210                 215                 220                 


Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr Leu 
225                 230                 235                 240 


Lys Val Lys Ala Asp Tyr Lys Asp Asp Asp Asp Lys His His His His 
                245                 250                 255     


His His 
        


<210>  2650
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - CTLA-4 2520

<400>  2650
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctttt       60

accgtaacgg tccctaagga tttgtacgtg gttgagtacg ggagcaatat gacgattgaa      120

tgcaagttcc ccgtagagaa gcagctcgat ttggccgctt tgatagtgta ctgggaaatg      180

gaaggaaaag acatcattca attcgtccac ggtgaagagg atcaaaaagc gcaacatagc      240

tcctatagac aacgcgcacg cttgcttaaa gaccagctga gtcttggtaa cgcggcgctg      300

cagattaccg acgtaaaact tcaagacgcg ggagtttatc gctgcatgat ttcctacggg      360

ggtggcgcag actataaaag gatcactgta aaggtaaacg ccggatccgg agggtctggg      420

ggaggcggtt ctgggggtgg aggctcaaag gcgatgcacg tagcccagcc cgctgttgtt      480

ctcgcaagtt ctcgcggcat agcctccttc gtatgtgagt atgccagtcc aggtaagtac      540

acggaggtac gggtaactgt actgcggcag gccgattccc aggttacgga ggtttgtgcg      600

gcaacctaca tgatgggtaa cgagcttaca tttctcgacg actcaatatg tactgggacc      660

tcctcaggaa atcaggtcaa tctgaccatc caaggtctga gggcgatgga tacgggtctt      720

tatatttgca aggttgaact catgtatccg cctccatact atgaaggcat tggaaatgga      780

acacaaatct atgttattga cccggagccg tctccagata gtgatcagga ttacaaggat      840

gacgacgata agcaccatca tcaccatcac tag                                   873


<210>  2651
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 303 - CTLA-4 2520

<400>  2651

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser 
    130                 135                 140                 


Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys 
145                 150                 155                 160 


Tyr Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val 
                165                 170                 175     


Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe 
            180                 185                 190         


Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn 
        195                 200                 205             


Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys 
    210                 215                 220                 


Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn 
225                 230                 235                 240 


Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp 
                245                 250                 255     


Gln Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
            260                 265                 270     


<210>  2652
<211>  843
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - CTLA-4 2520

<400>  2652
gccgccacca tggggtcaac cgccatcctc gccctcctcc tggctgttct ccaaggagtc       60

agcgctttat tcacagtgac tgttccgaaa gagttgtata taatcgagca agggagtaat      120

gttaccctgg aatgcaattt tgacaccggg tcacacgtca acctcggagc gattactgct      180

tctttgcaaa aagttgaaaa cgacgcgtcc ccccataggg aaagggcgac ccttctggag      240

gagcagttgc cccttggcag ggcactcttt cacattcccc aggtgcaagt cagggacgag      300

gggcaatacc gctgcatcat aatttacggg gacgcgtggg actacaagta cttgactctc      360

aaagttaaag ctggatccgg agggtctggg ggaggcggtt ctgggggtgg aggctcaaag      420

gcgatgcacg tagcccagcc cgctgttgtt ctcgcaagtt ctcgcggcat agcctccttc      480

gtatgtgagt atgccagtcc aggtaagtac acggaggtac gggtaactgt actgcggcag      540

gccgattccc aggttacgga ggtttgtgcg gcaacctaca tgatgggtaa cgagcttaca      600

tttctcgacg actcaatatg tactgggacc tcctcaggaa atcaggtcaa tctgaccatc      660

caaggtctga gggcgatgga tacgggtctt tatatttgca aggttgaact catgtatccg      720

cctccatact atgaaggcat tggaaatgga acacaaatct atgttattga cccggagccg      780

tctccagata gtgatcagga ttacaaggat gacgacgata agcaccatca tcaccatcac      840

tag                                                                    843


<210>  2653
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L2 1417 - CTLA-4 2520

<400>  2653

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val 
        115                 120                 125             


Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser 
    130                 135                 140                 


Pro Gly Lys Tyr Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp 
145                 150                 155                 160 


Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu 
                165                 170                 175     


Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn 
            180                 185                 190         


Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu 
        195                 200                 205             


Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly 
    210                 215                 220                 


Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro 
225                 230                 235                 240 


Asp Ser Asp Gln Asp Tyr Lys Asp Asp Asp Asp Lys His His His His 
                245                 250                 255     


His His 
        


<210>  2654
<211>  100
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD80 WT IgV

<400>  2654

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val 
            100 


<210>  2655
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 wild-type ECD

<400>  2655

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln 
        115                 120                 125         


<210>  2656
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v196 ECD

<400>  2656

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Glu Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2657
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v197 ECD

<400>  2657

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2658
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v198 ECD

<400>  2658

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2659
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v199 ECD

<400>  2659

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2660
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v200 ECD

<400>  2660

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2661
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v201 ECD

<400>  2661

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2662
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v202 ECD

<400>  2662

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2663
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v203 ECD

<400>  2663

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2664
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v204 ECD

<400>  2664

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2665
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v205 ECD

<400>  2665

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2666
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v206 ECD

<400>  2666

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2667
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v207 ECD

<400>  2667

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2668
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v208 ECD

<400>  2668

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Ala Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2669
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v209 ECD

<400>  2669

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2670
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v210 ECD

<400>  2670

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2671
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v211 ECD

<400>  2671

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2672
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v212 ECD

<400>  2672

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2673
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v213 ECD

<400>  2673

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Thr Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2674
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v214 ECD

<400>  2674

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2675
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v215 ECD

<400>  2675

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Asp Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2676
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v216 ECD

<400>  2676

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Arg Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2677
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v217 ECD

<400>  2677

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Pro Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2678
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v218 ECD

<400>  2678

Val Ile His Val Thr Lys Asp Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2679
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v219 ECD

<400>  2679

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2680
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v220 ECD

<400>  2680

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Arg Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Glu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2681
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v221 ECD

<400>  2681

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Lys Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2682
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v222 ECD

<400>  2682

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Ser Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Leu Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Gly Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2683
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v223 ECD

<400>  2683

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Thr 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2684
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v224 ECD

<400>  2684

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Gln Lys His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2685
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v225 ECD

<400>  2685

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Lys Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Glu Asp Ala Phe Arg Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2686
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v226 ECD

<400>  2686

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Ala Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Trp Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2687
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v227 ECD

<400>  2687

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Glu Tyr Glu Lys Asp Ala Phe Lys Trp Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2688
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v228 ECD

<400>  2688

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2689
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v229 ECD

<400>  2689

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Ala Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2690
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v230 ECD

<400>  2690

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Glu Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2691
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v231 ECD

<400>  2691

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Ser Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2692
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v232 ECD

<400>  2692

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr His Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2693
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v233 ECD

<400>  2693

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Trp Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2694
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v234 ECD

<400>  2694

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2695
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v235 ECD

<400>  2695

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2696
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v236 ECD

<400>  2696

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Val Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2697
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v237 ECD

<400>  2697

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2698
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v238 ECD

<400>  2698

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2699
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v239 ECD

<400>  2699

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2700
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v240 ECD

<400>  2700

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2701
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v241 ECD

<400>  2701

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Val Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2702
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v242 ECD

<400>  2702

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Ala Val Leu Lys His Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Met Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2703
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v243 ECD

<400>  2703

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2704
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v244 ECD

<400>  2704

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Thr Arg Val His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2705
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v245 ECD

<400>  2705

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2706
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v246 ECD

<400>  2706

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asp 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2707
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v247 ECD

<400>  2707

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr His Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Val Ser Gly Asp Ile Asn 
        35                  40                  45              


Val Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2708
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v248 ECD

<400>  2708

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2709
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v249 ECD

<400>  2709

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2710
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v250 ECD

<400>  2710

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2711
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v251 ECD

<400>  2711

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2712
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v252 ECD

<400>  2712

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Gln Glu Glu Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2713
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v253 ECD

<400>  2713

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Asn Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2714
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v254 ECD

<400>  2714

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2715
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v255 ECD

<400>  2715

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2716
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v256 ECD

<400>  2716

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2717
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v257 ECD

<400>  2717

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2718
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v258 ECD

<400>  2718

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2719
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v259 ECD

<400>  2719

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Val Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2720
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v260 ECD

<400>  2720

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Cys Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2721
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v261 ECD

<400>  2721

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2722
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v262 ECD

<400>  2722

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2723
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v263 ECD

<400>  2723

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2724
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v264 ECD

<400>  2724

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Thr 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2725
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v265 ECD

<400>  2725

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2726
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v266 ECD

<400>  2726

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2727
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v267 ECD

<400>  2727

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2728
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v268 ECD

<400>  2728

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2729
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v269 ECD

<400>  2729

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2730
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v270 ECD

<400>  2730

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2731
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v271 ECD

<400>  2731

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2732
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v272 ECD

<400>  2732

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Val Asp 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2733
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v273 ECD

<400>  2733

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2734
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v274 ECD

<400>  2734

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2735
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v275 ECD

<400>  2735

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2736
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v276 ECD

<400>  2736

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Val Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2737
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v277 ECD

<400>  2737

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asp Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2738
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v278 ECD

<400>  2738

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Glu Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2739
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v279 ECD

<400>  2739

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Glu Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2740
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v280 ECD

<400>  2740

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2741
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v281 ECD

<400>  2741

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Tyr Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2742
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v282 ECD

<400>  2742

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Val Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Asp Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2743
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v283 ECD

<400>  2743

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2744
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v284 ECD

<400>  2744

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2745
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v285 ECD

<400>  2745

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu His Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Arg Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2746
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v286 ECD

<400>  2746

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Val His Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Lys Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2747
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v287 ECD

<400>  2747

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2748
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v288 ECD

<400>  2748

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Thr Val Leu Thr Met Met Ser Gly Glu Val Ser 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2749
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v289 ECD

<400>  2749

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Leu Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2750
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v290 ECD

<400>  2750

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Thr Val Leu Thr Met Val Ser Gly Asp Val Arg 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2751
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v291 ECD

<400>  2751

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Tyr Arg Ile Tyr Trp 
            20                  25                  30          


His Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  2752
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v196 IgV

<400>  2752

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Glu Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2753
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v197 IgV

<400>  2753

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2754
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v198 IgV

<400>  2754

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2755
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v199 IgV

<400>  2755

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2756
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v200 IgV

<400>  2756

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2757
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v201 IgV

<400>  2757

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2758
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v202 IgV

<400>  2758

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2759
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v203 IgV

<400>  2759

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2760
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v204 IgV

<400>  2760

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2761
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v205 IgV

<400>  2761

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2762
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v206 IgV

<400>  2762

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2763
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v207 IgV

<400>  2763

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2764
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v208 IgV

<400>  2764

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Ala Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2765
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v209 IgV

<400>  2765

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2766
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v210 IgV

<400>  2766

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2767
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v211 IgV

<400>  2767

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2768
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v212 IgV

<400>  2768

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2769
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v213 IgV

<400>  2769

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Thr Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2770
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v214 IgV

<400>  2770

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2771
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v215 IgV

<400>  2771

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Asp Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2772
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v216 IgV

<400>  2772

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Arg Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2773
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v217 IgV

<400>  2773

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Pro Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2774
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v218 IgV

<400>  2774

Val Ile His Val Thr Lys Asp Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr 
            100     


<210>  2775
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v219 IgV

<400>  2775

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2776
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v220 IgV

<400>  2776

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Arg Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Glu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2777
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v221 IgV

<400>  2777

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Lys Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2778
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v222 IgV

<400>  2778

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Ser Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Leu Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Gly Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2779
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v223 IgV

<400>  2779

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Thr 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2780
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v224 IgV

<400>  2780

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Gln Lys His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2781
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v225 IgV

<400>  2781

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Lys Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Glu Asp Ala Phe Arg Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2782
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v226 IgV

<400>  2782

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Ala Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Trp Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2783
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v227 IgV

<400>  2783

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Glu Tyr Glu Lys Asp Ala Phe Lys Trp Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2784
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v228 IgV

<400>  2784

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2785
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v229 IgV

<400>  2785

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Ala Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2786
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v230 IgV

<400>  2786

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Glu Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2787
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v231 IgV

<400>  2787

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Ser Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2788
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v232 IgV

<400>  2788

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr His Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2789
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v233 IgV

<400>  2789

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Trp Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2790
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v234 IgV

<400>  2790

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr 
            100     


<210>  2791
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v235 IgV

<400>  2791

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2792
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v236 IgV

<400>  2792

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Val Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2793
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v237 IgV

<400>  2793

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr 
            100     


<210>  2794
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v238 IgV

<400>  2794

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr 
            100     


<210>  2795
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v239 IgV

<400>  2795

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2796
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v240 IgV

<400>  2796

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr 
            100     


<210>  2797
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v241 IgV

<400>  2797

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Val Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2798
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v242 IgV

<400>  2798

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Ala Val Leu Lys His Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Met Ala Glu Val Thr 
            100     


<210>  2799
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v243 IgV

<400>  2799

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr 
            100     


<210>  2800
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v244 IgV

<400>  2800

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Thr Arg Val His 
                85                  90                  95      


Gln Ala Glu Val Thr 
            100     


<210>  2801
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v245 IgV

<400>  2801

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2802
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v246 IgV

<400>  2802

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asp 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2803
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v247 IgV

<400>  2803

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr His Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Val Ser Gly Asp Ile Asn 
        35                  40                  45              


Val Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2804
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v248 IgV

<400>  2804

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2805
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v249 IgV

<400>  2805

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2806
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v250 IgV

<400>  2806

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2807
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v251 IgV

<400>  2807

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2808
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v252 IgV

<400>  2808

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Gln Glu Glu Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2809
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v253 IgV

<400>  2809

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Asn Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2810
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v254 IgV

<400>  2810

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2811
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v255 IgV

<400>  2811

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2812
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v256 IgV

<400>  2812

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2813
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v257 IgV

<400>  2813

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2814
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v258 IgV

<400>  2814

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2815
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v259 IgV

<400>  2815

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Val Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2816
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v260 IgV

<400>  2816

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Cys Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2817
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v261 IgV

<400>  2817

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2818
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v262 IgV

<400>  2818

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2819
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v263 IgV

<400>  2819

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2820
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v264 IgV

<400>  2820

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Thr 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2821
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v265 IgV

<400>  2821

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2822
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v266 IgV

<400>  2822

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2823
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v267 IgV

<400>  2823

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2824
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v268 IgV

<400>  2824

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2825
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v269 IgV

<400>  2825

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2826
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v270 IgV

<400>  2826

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2827
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v271 IgV

<400>  2827

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2828
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v272 IgV

<400>  2828

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Val Asp 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2829
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v273 IgV

<400>  2829

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2830
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v274 IgV

<400>  2830

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2831
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v275 IgV

<400>  2831

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2832
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v276 IgV

<400>  2832

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Val Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2833
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v277 IgV

<400>  2833

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asp Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2834
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v278 IgV

<400>  2834

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Glu Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2835
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v279 IgV

<400>  2835

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Glu Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2836
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v280 IgV

<400>  2836

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2837
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v281 IgV

<400>  2837

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Tyr Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2838
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v282 IgV

<400>  2838

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Val Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Asp Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2839
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v283 IgV

<400>  2839

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr 
            100     


<210>  2840
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v284 IgV

<400>  2840

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr 
            100     


<210>  2841
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v285 IgV

<400>  2841

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu His Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Arg Ala Glu Val Thr 
            100     


<210>  2842
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v286 IgV

<400>  2842

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Val His Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Lys Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2843
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v287 IgV

<400>  2843

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2844
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v288 IgV

<400>  2844

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Thr Val Leu Thr Met Met Ser Gly Glu Val Ser 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2845
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v289 IgV

<400>  2845

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Leu Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2846
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v290 IgV

<400>  2846

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Thr Val Leu Thr Met Val Ser Gly Asp Val Arg 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2847
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v291 IgV

<400>  2847

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Tyr Arg Ile Tyr Trp 
            20                  25                  30          


His Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  2848
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v196 IgV

<400>  2848

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Glu Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2849
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v197 IgV

<400>  2849

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2850
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v198 IgV

<400>  2850

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2851
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v199 IgV

<400>  2851

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2852
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v200 IgV

<400>  2852

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2853
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v201 IgV

<400>  2853

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2854
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v202 IgV

<400>  2854

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2855
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v203 IgV

<400>  2855

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2856
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v204 IgV

<400>  2856

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2857
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v205 IgV

<400>  2857

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2858
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v206 IgV

<400>  2858

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2859
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v207 IgV

<400>  2859

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2860
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v208 IgV

<400>  2860

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Ala Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2861
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v209 IgV

<400>  2861

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2862
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v210 IgV

<400>  2862

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2863
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v211 IgV

<400>  2863

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2864
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v212 IgV

<400>  2864

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2865
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v213 IgV

<400>  2865

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Thr Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2866
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v214 IgV

<400>  2866

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2867
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v215 IgV

<400>  2867

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Asp Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2868
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v216 IgV

<400>  2868

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Arg Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2869
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v217 IgV

<400>  2869

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Pro Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2870
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v218 IgV

<400>  2870

Val Ile His Val Thr Lys Asp Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2871
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v219 IgV

<400>  2871

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2872
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v220 IgV

<400>  2872

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Arg Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Glu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2873
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v221 IgV

<400>  2873

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Lys Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2874
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v222 IgV

<400>  2874

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Ser Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Leu Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Gly Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2875
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v223 IgV

<400>  2875

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Thr 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2876
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v224 IgV

<400>  2876

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Gln Lys His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2877
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v225 IgV

<400>  2877

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Lys Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Glu Asp Ala Phe Arg Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2878
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v226 IgV

<400>  2878

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Ala Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Trp Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2879
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v227 IgV

<400>  2879

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Glu Tyr Glu Lys Asp Ala Phe Lys Trp Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2880
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v228 IgV

<400>  2880

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2881
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v229 IgV

<400>  2881

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Ala Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2882
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v230 IgV

<400>  2882

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Glu Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2883
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v231 IgV

<400>  2883

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Ser Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2884
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v232 IgV

<400>  2884

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr His Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2885
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v233 IgV

<400>  2885

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Trp Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2886
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v234 IgV

<400>  2886

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2887
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v235 IgV

<400>  2887

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2888
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v236 IgV

<400>  2888

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Val Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2889
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v237 IgV

<400>  2889

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2890
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v238 IgV

<400>  2890

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2891
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v239 IgV

<400>  2891

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2892
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v240 IgV

<400>  2892

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2893
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v241 IgV

<400>  2893

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Val Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2894
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v242 IgV

<400>  2894

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Ala Val Leu Lys His Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Met Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2895
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v243 IgV

<400>  2895

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2896
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v244 IgV

<400>  2896

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Thr Arg Val His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2897
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v245 IgV

<400>  2897

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2898
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v246 IgV

<400>  2898

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asp 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2899
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v247 IgV

<400>  2899

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr His Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Val Ser Gly Asp Ile Asn 
        35                  40                  45              


Val Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2900
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v248 IgV

<400>  2900

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2901
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v249 IgV

<400>  2901

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2902
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v250 IgV

<400>  2902

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2903
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v251 IgV

<400>  2903

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2904
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v252 IgV

<400>  2904

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Gln Glu Glu Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2905
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v253 IgV

<400>  2905

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Asn Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2906
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v254 IgV

<400>  2906

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2907
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v255 IgV

<400>  2907

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2908
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v256 IgV

<400>  2908

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2909
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v257 IgV

<400>  2909

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2910
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v258 IgV

<400>  2910

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2911
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v259 IgV

<400>  2911

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Val Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2912
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v260 IgV

<400>  2912

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Cys Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2913
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v261 IgV

<400>  2913

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2914
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v262 IgV

<400>  2914

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2915
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v263 IgV

<400>  2915

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2916
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v264 IgV

<400>  2916

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Thr 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2917
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v265 IgV

<400>  2917

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2918
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v266 IgV

<400>  2918

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2919
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v267 IgV

<400>  2919

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2920
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v268 IgV

<400>  2920

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2921
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v269 IgV

<400>  2921

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2922
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v270 IgV

<400>  2922

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2923
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v271 IgV

<400>  2923

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2924
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v272 IgV

<400>  2924

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Val Asp 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2925
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v273 IgV

<400>  2925

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2926
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v274 IgV

<400>  2926

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Leu Glu Glu Leu Ala His Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2927
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v275 IgV

<400>  2927

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2928
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v276 IgV

<400>  2928

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Val Ser Gly Asp Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2929
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v277 IgV

<400>  2929

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asp Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2930
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v278 IgV

<400>  2930

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Glu Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2931
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v279 IgV

<400>  2931

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Glu Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2932
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v280 IgV

<400>  2932

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2933
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v281 IgV

<400>  2933

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Tyr Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2934
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v282 IgV

<400>  2934

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Val Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Asp Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2935
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v283 IgV

<400>  2935

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2936
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v284 IgV

<400>  2936

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2937
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v285 IgV

<400>  2937

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu His Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Arg Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2938
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v286 IgV

<400>  2938

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Asp Val His Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Lys Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2939
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v287 IgV

<400>  2939

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Leu Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2940
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v288 IgV

<400>  2940

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Thr Val Leu Thr Met Met Ser Gly Glu Val Ser 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2941
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v289 IgV

<400>  2941

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Leu Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2942
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v290 IgV

<400>  2942

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Asp Lys Lys Thr Val Leu Thr Met Val Ser Gly Asp Val Arg 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2943
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v291 IgV

<400>  2943

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Tyr Arg Ile Tyr Trp 
            20                  25                  30          


His Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  2944
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tCD28

<400>  2944

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
            180                 185             


<210>  2945
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 ECD

<400>  2945

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Met His Val Ala Gln Pro 
            20                  25                  30          


Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu 
        35                  40                  45              


Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg 
    50                  55                  60                  


Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met 
65                  70                  75                  80  


Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser 
                85                  90                  95      


Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp 
            100                 105                 110         


Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr 
        115                 120                 125             


Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu 
    130                 135                 140                 


Pro Cys Pro Asp Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His 
145                 150                 155                 160 


Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val 
                165                 170                 175     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            180                 185                 190         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        195                 200                 205             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    210                 215                 220                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
225                 230                 235                 240 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                245                 250                 255     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            260                 265                 270         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        275                 280                 285             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    290                 295                 300                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
305                 310                 315                 320 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                325                 330                 335     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            340                 345                 350         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        355                 360                 365             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380             


<210>  2946
<211>  92
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  LFA-3 IgV

<400>  2946

Ser Gln Gln Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His Val 
1               5                   10                  15      


Pro Ser Asn Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys Asp 
            20                  25                  30          


Lys Val Ala Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser Phe 
        35                  40                  45              


Lys Asn Arg Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr 
    50                  55                  60                  


Asn Leu Thr Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn 
65                  70                  75                  80  


Ile Thr Asp Thr Met Lys Phe Phe Leu Tyr Val Leu 
                85                  90          


<210>  2947
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  unmodified CTLA-4 IgV (39-140 of P16410)

<400>  2947

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  2948
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P/L98Q/Y105L ECD

<400>  2948

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2949
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98R/N110K ECD

<400>  2949

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Arg Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Lys Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2950
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T ECD

<400>  2950

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2951
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P ECD

<400>  2951

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2952
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/Y105L ECD

<400>  2952

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2953
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98Q/Y105L ECD

<400>  2953

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2954
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P ECD

<400>  2954

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2955
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98R/N110K ECD

<400>  2955

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Arg Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Lys Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2956
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P/L98Q/M99L/Y105L ECD

<400>  2956

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2957
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/Q82H/L98Q/M99L/Y105L ECD

<400>  2957

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Met Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile His Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2958
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/L98Q/M99L/Y105L ECD

<400>  2958

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2959
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S14N/R16C/I18T/M56K/T61A/L63P/A86T/M99L ECD

<400>  2959

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Asn Ser Cys 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Lys Gly Asn Glu Leu Ala Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Thr Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2960
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S27P/M56K/L63P/S72G/S73R/T89A/M99L/Y105L/I117M ECD

<400>  2960

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Pro Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Arg Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Met Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2961
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56K/L63P/N75D/V96I/M99L/Y105L/L106I ECD

<400>  2961

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asp Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Ile 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2962
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/Y105L ECD

<400>  2962

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2963
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/M99L/Y105L/I117M ECD

<400>  2963

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Met Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2964
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/L98Q/M99L/Y105L/L106I/I117L ECD

<400>  2964

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2965
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/S72G/L98Q/Y105L/L106I/I117L ECD

<400>  2965

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2966
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/V116A ECD

<400>  2966

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Ala Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2967
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L98Q/M99L/Y105L ECD

<400>  2967

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2968
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T37S/M56V/L98Q/Y105L ECD

<400>  2968

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Ser Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Val Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2969
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/Y54F/M56K/M99L/Y105L ECD

<400>  2969

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Phe Met Lys Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2970
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/I18T/A26T/M55T/T69S/S72G/M99L/Y105L ECD

<400>  2970

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Ser Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2971
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V22I/L63P/L98Q/Y105L/I117M ECD

<400>  2971

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Ile Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Met Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2972
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  2972

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2973
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/A42T/L98Q/Y105L ECD

<400>  2973

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Met Val Arg Val Thr Val Leu Arg Gln Thr Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2974
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M55T/E97Q/M99L/Y105F ECD

<400>  2974

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Gln Leu Leu Tyr Pro Pro Pro Tyr Phe Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2975
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M55T/S72G/L98Q/M99L/Y105L ECD

<400>  2975

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2976
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R16C/G29W/E33V/M55T/L63P/L98Q/Y105L ECD

<400>  2976

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Cys 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2977
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P/L98Q/Y105L/L106I ECD

<400>  2977

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2978
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56L/L63P/L98Q/Y105L/L106I/I117L ECD

<400>  2978

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Leu Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2979
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S15P/I18V/M56T/L98Q/M99L/Y105L ECD

<400>  2979

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Pro Arg 
1               5                   10                  15      


Gly Val Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2980
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/G29W/L63P/L98Q/Y105L ECD

<400>  2980

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2981
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/Q82H/L98Q/M99L/Y105L ECD

<400>  2981

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile His Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2982
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98Q/M99L/Y105L/L106I/I117T ECD

<400>  2982

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Thr Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2983
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98Q/M99L/Y105L/L106I/Y115N ECD

<400>  2983

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Asn Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2984
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M55T/L63P/T71I/M99L/Y105L ECD

<400>  2984

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Ile Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2985
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/T53S/M56K/L63P/L98Q/Y105L ECD

<400>  2985

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2986
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/A26T/L63P/Q82R/L98Q/Y105L ECD

<400>  2986

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2987
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12H/M55T/E59D/L63P/M99L ECD

<400>  2987

Lys Ala Met His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Asp Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2988
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/L63P/S72G/L98Q/Y105L/I108V ECD

<400>  2988

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Val Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2989
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  2989

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2990
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T61A/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  2990

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Ala Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2991
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V38I/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  2991

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Ile Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2992
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/I93L/L98Q/M99L/Y105L ECD

<400>  2992

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Leu Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2993
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12I/M55T/M56V/I67T/M99L/L106R/I108F ECD

<400>  2993

Lys Ala Met His Val Ala Gln Pro Ala Val Val Ile Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Val Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Thr Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Tyr Arg Gly Phe Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2994
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18N/A26T/L63H/T89A/L98Q/M99L/Y105L ECD

<400>  2994

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Asn Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe His Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2995
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/E48R/L63P/T69S/L98Q/Y105L/N110Y ECD

<400>  2995

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Arg 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Ser Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Tyr Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2996
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18N/L63P/S72T/M87T/L98Q/Y105L/N110S ECD

<400>  2996

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Asn Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Thr Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Thr Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Ser Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2997
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M56T/L63P/L98Q/Y105L/L106I/I117L ECD

<400>  2997

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2998
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/M87T/L98Q/M99L/Y105L ECD

<400>  2998

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Thr Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2999
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/D64N/L98Q/M99L/Y105L ECD

<400>  2999

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asn 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3000
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/L63P/S72G/M87K/L98Q/M99L/Y105L ECD

<400>  3000

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Lys Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3001
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56V ECD

<400>  3001

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Val Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3002
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/K95R ECD

<400>  3002

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Arg Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3003
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q ECD

<400>  3003

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3004
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98Q/M99L/Y105L ECD

<400>  3004

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3005
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/M87K/M99L/L106R ECD

<400>  3005

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Lys Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Tyr Arg Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3006
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/M99L/Y105L/I108F ECD

<400>  3006

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Phe Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3007
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V10A/L63P/L98Q/Y105L ECD

<400>  3007

Lys Ala Met His Val Ala Gln Pro Ala Ala Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3008
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56T/L91R/L98Q/Y105L ECD

<400>  3008

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Arg Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3009
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/M87V/N110K/I117E ECD

<400>  3009

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Lys Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Glu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3010
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/L98Q/M99L/Y105L ECD

<400>  3010

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3011
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/V46E/L63P/D65G/L98Q ECD

<400>  3011

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Glu Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Gly Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3012
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/L98Q/Y105L ECD

<400>  3012

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3013
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/E59G/L63P/L98Q/Y105L ECD

<400>  3013

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Gly Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3014
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12H/L63P/S72G/L98Q/Y105L ECD

<400>  3014

Lys Ala Met His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3015
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A6T/A26T/M55T/M99L/Y105L ECD

<400>  3015

Lys Ala Met His Val Thr Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3016
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/D65G/L98Q/M99L/Y105L ECD

<400>  3016

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Gly Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3017
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V10A/L63P/D64V/S72G/L98Q/M99L/Y105L ECD

<400>  3017

Lys Ala Met His Val Ala Gln Pro Ala Ala Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Val 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3018
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/G29W/D43N/N58S/L63P/L98Q/M99L/Y105L ECD

<400>  3018

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asn Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3019
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18V/A26T/L63P/D64E/L98Q/Y105L/L106R/N110K ECD

<400>  3019

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Val Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Glu 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Arg Gly Ile Gly Lys Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3020
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A19V/G29W/R35K/L63P/L98Q/M99L/Y105L ECD

<400>  3020

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Val Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Lys Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3021
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P/S72G/T89M/L98Q/M99L/Y105L ECD

<400>  3021

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Met Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3022
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P28L/E33V/L63P/S72G/L98R/M99L/Y105L ECD

<400>  3022

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Leu Gly Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Arg Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3023
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E24Q/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  3023

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Gln Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3024
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/G29R/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  3024

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Arg Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3025
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/M99L/Y105L ECD

<400>  3025

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3026
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q41L/Y54F/M56K/M99L/I108F ECD

<400>  3026

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Leu Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Phe Met Lys Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Tyr Leu Gly Phe Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3027
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S72G/L98Q/M99L/Y105L/I117T ECD

<400>  3027

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Thr Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3028
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56R/L63P/L98Q/M99L/Y105L ECD

<400>  3028

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Arg Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3029
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/L63P/S72G/L98Q/Y105L ECD

<400>  3029

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Met Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3030
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/M99L/Y105L/L106I ECD

<400>  3030

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3031
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/M55R/L98Q/M99L/Y105L ECD

<400>  3031

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Arg Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3032
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/M87A/L98Q/Y105L ECD

<400>  3032

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Ala Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3033
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26D/S72G/L98Q/M99L/Y105L ECD

<400>  3033

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Asp Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3034
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V22A/L63P/L98Q/M99L/Y105L/P119H ECD

<400>  3034

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Ala Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp His Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3035
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/M55T/L63P/L98Q/M99L/Y105L ECD

<400>  3035

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3036
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33V/A42S/M55T/L98Q/M99L/Y105L ECD

<400>  3036

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ser Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3037
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/Q82R/L98Q/Y105L ECD

<400>  3037

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3038
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/L63P/S72G/L98Q/Y105L/I117L ECD

<400>  3038

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Met Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3039
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/I67N/S72G/L98Q/M99L/Y105L ECD

<400>  3039

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Asn Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3040
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12F/A26T/L63P/L98Q/Y105L/L106R ECD

<400>  3040

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Arg Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3041
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S20N/A26T/L63P/L98Q/M99L/Y105L ECD

<400>  3041

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Asn Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3042
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Green fluorescent protein

<400>  3042

Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
1               5                   10                  15      


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
            20                  25                  30          


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
        35                  40                  45              


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Ser 
    50                  55                  60                  


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
65                  70                  75                  80  


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
                85                  90                  95      


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
            100                 105                 110         


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
        115                 120                 125             


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
    130                 135                 140                 


Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile 
145                 150                 155                 160 


Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
                165                 170                 175     


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
            180                 185                 190         


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
        195                 200                 205             


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
    210                 215                 220                 


Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235         


<210>  3043
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T61I/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  3043

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Ile Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3044
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/T69I/L98Q/M99L/Y105L ECD

<400>  3044

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Ile Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3045
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/L63P/S72G/L98Q/M99L/Y105L/L106N ECD

<400>  3045

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Asn Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3046
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/T69A/L98Q/M99L/Y105L/L106R/V116A ECD

<400>  3046

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Ala Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Arg Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Ala Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3047
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/S72G/L98Q/Y105L ECD

<400>  3047

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3048
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/D65G/S72G/L98Q/Y105L ECD

<400>  3048

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Gly Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3049
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enhanced green fluorescent protein (eEGFP)

<400>  3049

Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
1               5                   10                  15      


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
            20                  25                  30          


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
        35                  40                  45              


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
    50                  55                  60                  


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
65                  70                  75                  80  


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
                85                  90                  95      


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
            100                 105                 110         


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
        115                 120                 125             


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
    130                 135                 140                 


Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile 
145                 150                 155                 160 


Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
                165                 170                 175     


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
            180                 185                 190         


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
        195                 200                 205             


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
    210                 215                 220                 


Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235         


<210>  3050
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T53S/M56V/L98Q/Y105L ECD

<400>  3050

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Val Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3051
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/L98Q/Y105L ECD

<400>  3051

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3052
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18A/L63P/S72G/L98Q/Y105L ECD

<400>  3052

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ala Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3053
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/L63P/L98Q/Y105L ECD

<400>  3053

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3054
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18V/G29W/L63P/S72G/L98Q/Y105L ECD

<400>  3054

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Val Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3055
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/S72G/L98Q/Y105L/L106I ECD

<400>  3055

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3056
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/I67V/S72G/L98Q/Y105L ECD

<400>  3056

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Val Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3057
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M55V/E59G/L63P/L98Q/Y105L ECD

<400>  3057

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Val Met Gly Asn Gly Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3058
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/S72G/L98Q/Y105L/I117L ECD

<400>  3058

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3059
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/L98Q/Y105L/L106I/I117L ECD

<400>  3059

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3060
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12F/R16H/G29W/M56T/L98Q/Y105L ECD

<400>  3060

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3061
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/G29W/L63P/S72G/L98Q/Y105L ECD

<400>  3061

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3062
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/G29W/L63P/S72G/L98Q/Y105L/L106I ECD

<400>  3062

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3063
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/S72G/L98Q/Y105L/L106I/I117L ECD

<400>  3063

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3064
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/S72G/L98Q/Y105L/L106I ECD

<400>  3064

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3065
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/T53S/L63P/L98Q/Y105L/L106I/I117L ECD

<400>  3065

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3066
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/S72G/M87V/L98Q/Y105L ECD

<400>  3066

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3067
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/S72G/Q76R/L98Q/Y105L/L106I/Q113H ECD

<400>  3067

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Arg Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


His Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3068
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/S72G/L98Q/Y105L/L106V ECD

<400>  3068

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Val Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3069
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/L98Q/M99L/Y105L ECD

<400>  3069

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3070
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58D/I67V/L98Q/M99L/Y105L ECD

<400>  3070

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asp Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Val Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3071
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I67V/S72G/Q82H/T89A/L98Q/M99L/Y105L ECD

<400>  3071

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Val Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile His Gly Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3072
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S72G/R85G/L98Q/M99L/Y105L/L106I ECD

<400>  3072

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Gly Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3073
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/T47A/M56K/L63P/S72G/Q82R/L98Q/M99L/Y105L ECD

<400>  3073

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Ala Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3074
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/M55T/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  3074

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3075
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12H/I18V/A42T/M55T/N58D/L98R/Y105L/L106I/P121S ECD

<400>  3075

Lys Ala Met His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg 
1               5                   10                  15      


Gly Val Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Thr Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asp Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Arg Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Ser Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3076
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/A26T/L63P/S72G/L98Q/Y105L ECD

<400>  3076

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3077
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12F/K30R/S72G/Q82R/L98Q/M99L/Y105L ECD

<400>  3077

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Arg Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3078
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/L63P/S72G/L98Q/M99L/Y105L/L106N/I117L ECD

<400>  3078

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Asn Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3079
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M87K/I93V/L98Q/M99L/Y105L ECD

<400>  3079

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Lys Asp Thr Gly Leu Tyr Val Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3080
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P28L/E33V/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  3080

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Leu Gly Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3081
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/L63P/Q82H/L98Q/M99I/Y105L ECD

<400>  3081

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile His Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Ile Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3082
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18F/L63P/L98Q/M99L/Y105L/P121S ECD

<400>  3082

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Phe Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Ser Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3083
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/M99L/Y105L/I108V ECD

<400>  3083

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Val Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3084
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/A42V/Q45H/I67N/M87K/E97Q/M99L ECD

<400>  3084

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Val Asp Ser His Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Asn Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Lys Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Gln Leu Leu Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3085
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56V/E59G/L63P/S72G/M87K/I93V/L98Q/M99L/Y105L/I117E ECD

<400>  3085

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Val Gly Asn Gly Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Lys Asp Thr Gly Leu Tyr Val Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Glu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3086
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M87K/T89S/L98Q/M99L/Y105L/I108V/I117L ECD

<400>  3086

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Lys Asp Ser Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Val Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3087
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/M56V/L63P/V96I/L98Q/M99L/Y105L/Y115H ECD

<400>  3087

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Val Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Ile 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile His Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3088
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/T61N/L63P/L98Q/Y105L ECD

<400>  3088

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Asn Glu Leu Asn Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3089
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/A26S/M55T/M56V/L63P/S72G/L98Q/M99L/Y105L/I117K ECD

<400>  3089

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ser Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Val Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Lys Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3090
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/T61R/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  3090

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Arg Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3091
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  3091

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3092
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/L63P/S72G/L98Q/Y105L/I108F ECD

<400>  3092

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Met Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Phe Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3093
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/R16H/A26T/T61S/L63P/M87V/L98Q/M99L/Y105L/L106I/I117L ECD

<400>  3093

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Ser Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3094
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/N58S/L63P/M87V/L98Q/Y105L/P121S ECD

<400>  3094

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Ser Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3095
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/S72G/L98Q/Y105L/P121S ECD

<400>  3095

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Ser Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3096
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/N58S/L63P/M87V/L98Q/Y105L ECD

<400>  3096

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3097
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/N58S/L63P/M87V/L98Q/Y105L/I108V ECD

<400>  3097

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Val Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3098
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/L63P/S72G/L98Q/Y105L ECD

<400>  3098

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3099
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V10A/G29W/T53S/M56K/L63P/L98Q/Y105L/P121S ECD

<400>  3099

Lys Ala Met His Val Ala Gln Pro Ala Ala Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Ser Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3100
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P/L98Q/Y105L IgV

<400>  3100

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3101
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98R IgV domain (of L63P/L98R/N110K - IgV doesn't contain 
       N110 residue)

<400>  3101

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Arg Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3102
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T IgV domain

<400>  3102

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3103
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P IgV domain

<400>  3103

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3104
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/Y105L IgV domain

<400>  3104

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3105
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98Q/Y105L IgV domain

<400>  3105

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3106
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P IgV domain

<400>  3106

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3107
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98R IgV domain (of L98R/N110K - IgV doesn't contain N110 
       residue)

<400>  3107

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Arg Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3108
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P/L98Q/M99L/Y105L IgV domain

<400>  3108

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3109
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/Q82H/L98Q/M99L/Y105L IgV domain

<400>  3109

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Met Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile His Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3110
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  3110

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3111
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S14N/R16C/I18T/M56K/T61A/L63P/A86T/M99L IgV domain

<400>  3111

His Val Ala Gln Pro Ala Val Val Leu Ala Asn Ser Cys Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Lys Gly Asn Glu Leu Ala Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Thr Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3112
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S27P/M56K/L63P/S72G/S73R/T89A/M99L/Y105L IgV domain

<400>  3112

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Pro Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Arg Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3113
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56K/L63P/N75D/V96I/M99L/Y105L IgV domain

<400>  3113

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asp Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Ile Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3114
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/Y105L IgV domain

<400>  3114

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3115
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/S72G/L98Q/Y105L IgV domain

<400>  3115

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3116
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L98Q/M99L/Y105L IgV domain

<400>  3116

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3117
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T37S/M56V/L98Q/Y105L IgV domain

<400>  3117

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Ser Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Val Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3118
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/Y54F/M56K/M99L/Y105L IgV domain

<400>  3118

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Phe Met Lys Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3119
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/I18T/A26T/M55T/T69S/S72G/M99L/Y105L IgV domain

<400>  3119

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Ser Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3120
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V22I/L63P/L98Q/Y105L IgV domain

<400>  3120

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Ile Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3121
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  3121

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3122
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/A42T/L98Q/Y105L IgV domain

<400>  3122

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Met Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Thr Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3123
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M55T/E97Q/M99L/Y105F IgV domain

<400>  3123

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Gln Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Phe 
            100         


<210>  3124
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M55T/S72G/L98Q/M99L/Y105L IgV domain

<400>  3124

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3125
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R16C/G29W/E33V/M55T/L63P/L98Q/Y105L IgV domain

<400>  3125

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Cys Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3126
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56L/L63P/L98Q/Y105L IgV domain

<400>  3126

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Leu Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3127
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S15P/I18V/M56T/L98Q/M99L/Y105L IgV domain

<400>  3127

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Pro Arg Gly Val Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3128
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/G29W/L63P/L98Q/Y105L IgV domain

<400>  3128

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3129
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/Q82H/L98Q/M99L/Y105L IgV domain

<400>  3129

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile His Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3130
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M55T/L63P/T71I/M99L/Y105L IgV domain

<400>  3130

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Ile Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3131
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/T53S/M56K/L63P/L98Q/Y105L IgV domain

<400>  3131

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3132
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/A26T/L63P/Q82R/L98Q/Y105L IgV domain

<400>  3132

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Arg Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3133
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12H/M55T/E59D/L63P/M99L IgV domain

<400>  3133

His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Asp Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3134
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/L63P/S72G/L98Q/Y105L IgV domain

<400>  3134

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3135
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  3135

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3136
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T61A/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  3136

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Ala Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3137
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V38I/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  3137

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Ile Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3138
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/I93L/L98Q/M99L/Y105L IgV domain

<400>  3138

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Leu Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3139
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12I/M55T/M56V/I67T/M99L IgV domain

<400>  3139

His Val Ala Gln Pro Ala Val Val Ile Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Val Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Thr 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3140
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18N/A26T/L63H/T89A/L98Q/M99L/Y105L IgV domain

<400>  3140

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Asn Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe His Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3141
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/E48R/L63P/T69S/L98Q/Y105L IgV domain

<400>  3141

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Arg Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Ser Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3142
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18N/L63P/S72T/M87T/L98Q/Y105L IgV domain

<400>  3142

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Asn Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Thr Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Thr Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3143
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M56T/L63P/L98Q/Y105L IgV domain

<400>  3143

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3144
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/M87T/L98Q/M99L/Y105L IgV domain

<400>  3144

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Thr Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3145
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/D64N/L98Q/M99L/Y105L IgV domain

<400>  3145

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asn Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3146
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/L63P/S72G/M87K/L98Q/M99L/Y105L IgV domain

<400>  3146

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Lys Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3147
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56V IgV domain

<400>  3147

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Val Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3148
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/K95R IgV domain

<400>  3148

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Arg Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3149
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q IgV domain

<400>  3149

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3150
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98Q/M99L/Y105L IgV domain

<400>  3150

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3151
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/M87K/M99L IgV domain

<400>  3151

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Lys Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3152
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/M99L/Y105L IgV domain

<400>  3152

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3153
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V10A/L63P/L98Q/Y105L IgV domain

<400>  3153

His Val Ala Gln Pro Ala Ala Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3154
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56T/L91R/L98Q/Y105L IgV domain

<400>  3154

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Arg Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3155
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/M87V IgV domain

<400>  3155

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3156
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/L98Q/M99L/Y105L IgV domain

<400>  3156

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3157
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/V46E/L63P/D65G/L98Q IgV domain

<400>  3157

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Glu Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Gly Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3158
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/L98Q/Y105L IgV domain

<400>  3158

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3159
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/E59G/L63P/L98Q/Y105L IgV domain

<400>  3159

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Gly Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3160
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12H/L63P/S72G/L98Q/Y105L IgV domain

<400>  3160

His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3161
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A6T/A26T/M55T/M99L/Y105L IgV domain

<400>  3161

His Val Thr Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3162
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/D65G/L98Q/M99L/Y105L IgV domain

<400>  3162

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Gly Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3163
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V10A/L63P/D64V/S72G/L98Q/M99L/Y105L IgV domain

<400>  3163

His Val Ala Gln Pro Ala Ala Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Val Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3164
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/G29W/D43N/N58S/L63P/L98Q/M99L/Y105L IgV domain

<400>  3164

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asn Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3165
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18V/A26T/L63P/D64E/L98Q/Y105L IgV domain

<400>  3165

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Val Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Glu Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3166
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A19V/G29W/R35K/L63P/L98Q/M99L/Y105L IgV domain

<400>  3166

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Val 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Lys 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3167
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P/S72G/T89M/L98Q/M99L/Y105L IgV domain

<400>  3167

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Met Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3168
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P28L/E33V/L63P/S72G/L98R/M99L/Y105L IgV domain

<400>  3168

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Leu Gly Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Arg Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3169
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E24Q/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  3169

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Gln Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3170
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/G29R/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  3170

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Arg Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3171
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/M99L/Y105L IgV domain

<400>  3171

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3172
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q41L/Y54F/M56K/M99L IgV domain

<400>  3172

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Leu Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Phe Met Lys Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3173
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S72G/L98Q/M99L/Y105L IgV domain

<400>  3173

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3174
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56R/L63P/L98Q/M99L/Y105L IgV domain

<400>  3174

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Arg Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3175
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/L63P/S72G/L98Q/Y105L IgV domain

<400>  3175

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Met Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3176
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/M55R/L98Q/M99L/Y105L IgV domain

<400>  3176

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Arg Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3177
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/M87A/L98Q/Y105L IgV domain

<400>  3177

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Ala Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3178
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26D/S72G/L98Q/M99L/Y105L IgV domain

<400>  3178

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Asp Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3179
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V22A/L63P/L98Q/M99L/Y105L IgV domain

<400>  3179

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Ala Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3180
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/M55T/L63P/L98Q/M99L/Y105L IgV domain

<400>  3180

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3181
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33V/A42S/M55T/L98Q/M99L/Y105L IgV domain

<400>  3181

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ser Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3182
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/Q82R/L98Q/Y105L IgV domain

<400>  3182

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Arg Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3183
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/I67N/S72G/L98Q/M99L/Y105L IgV domain

<400>  3183

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Asn 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3184
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12F/A26T/L63P/L98Q/Y105L IgV domain

<400>  3184

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3185
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S20N/A26T/L63P/L98Q/M99L/Y105L IgV domain

<400>  3185

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Asn Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3186
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M87K/T89S/L98Q/M99L/Y105L IgV domain

<400>  3186

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Lys Asp Ser Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3187
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T61I/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  3187

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Ile Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3188
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/T69I/L98Q/M99L/Y105L IgV domain

<400>  3188

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Ile Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3189
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  3189

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3190
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/T69A/L98Q/M99L/Y105L IgV domain

<400>  3190

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Ala Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3191
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/S72G/L98Q/Y105L IgV domain

<400>  3191

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3192
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/D65G/S72G/L98Q/Y105L IgV domain

<400>  3192

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Gly Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3193
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T53S/M56V/L98Q/Y105L IgV domain

<400>  3193

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Val Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3194
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/L98Q/Y105L IgV domain

<400>  3194

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3195
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18A/L63P/S72G/L98Q/Y105L IgV domain

<400>  3195

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ala Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3196
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/L63P/L98Q/Y105L IgV domain

<400>  3196

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3197
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18V/G29W/L63P/S72G/L98Q/Y105L IgV domain

<400>  3197

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Val Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3198
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/S72G/L98Q/Y105L IgV domain

<400>  3198

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3199
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/I67V/S72G/L98Q/Y105L IgV domain

<400>  3199

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Val 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3200
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M55V/E59G/L63P/L98Q/Y105L IgV domain

<400>  3200

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Val Met Gly Asn Gly Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3201
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12F/R16H/G29W/M56T/L98Q/Y105L IgV domain

<400>  3201

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3202
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/G29W/L63P/S72G/L98Q/Y105L IgV domain

<400>  3202

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3203
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/T53S/L63P/L98Q/Y105L IgV domain

<400>  3203

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3204
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/S72G/M87V/L98Q/Y105L IgV domain

<400>  3204

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3205
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/S72G/Q76R/L98Q/Y105L IgV domain

<400>  3205

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Arg Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3206
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/L98Q/M99L/Y105L IgV domain

<400>  3206

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3207
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58D/I67V/L98Q/M99L/Y105L IgV domain

<400>  3207

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asp Glu Leu Thr Phe Leu Asp Asp Ser Val 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3208
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I67V/S72G/Q82H/T89A/L98Q/M99L/Y105L IgV domain

<400>  3208

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Val 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile His Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3209
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S72G/R85G/L98Q/M99L/Y105L IgV domain

<400>  3209

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Gly Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3210
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/T47A/M56K/L63P/S72G/Q82R/L98Q/M99L/Y105L IgV domain

<400>  3210

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Ala Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Arg Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3211
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/M55T/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  3211

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3212
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12H/I18V/A42T/M55T/N58D/L98R/Y105L IgV domain

<400>  3212

His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg Gly Val Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Thr Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asp Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Arg Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3213
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/A26T/L63P/S72G/L98Q/Y105L IgV domain

<400>  3213

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3214
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12F/K30R/S72G/Q82R/L98Q/M99L/Y105L IgV domain

<400>  3214

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Arg Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Arg Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3215
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M87K/I93V/L98Q/M99L/Y105L IgV domain

<400>  3215

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Lys Asp Thr Gly Leu Tyr Val Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3216
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P28L/E33V/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  3216

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Leu Gly Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3217
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/L63P/Q82H/L98Q/M99I/Y105L IgV domain

<400>  3217

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile His Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Ile 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3218
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18F/L63P/L98Q/M99L/Y105L IgV domain

<400>  3218

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Phe Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3219
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/A42V/Q45H/I67N/M87K/E97Q/M99L IgV domain

<400>  3219

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Val Asp Ser His Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Asn 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Lys Asp Thr Gly Leu Tyr Ile Cys Lys Val Gln Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3220
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56V/E59G/L63P/S72G/M87K/I93V/L98Q/M99L/Y105L IgV domain

<400>  3220

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Val Gly Asn Gly Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Lys Asp Thr Gly Leu Tyr Val Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3221
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/M56V/L63P/V96I/L98Q/M99L/Y105L IgV domain

<400>  3221

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Val Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Ile Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3222
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/T61N/L63P/L98Q/Y105L IgV domain

<400>  3222

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Asn Glu Leu Asn Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3223
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/A26S/M55T/M56V/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  3223

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ser Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Val Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3224
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/T61R/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  3224

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Arg Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3225
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  3225

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3226
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/R16H/A26T/T61S/L63P/M87V/L98Q/M99L/Y105L IgV domain

<400>  3226

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Ser Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3227
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/N58S/L63P/M87V/L98Q/Y105L IgV domain

<400>  3227

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3228
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/L63P/S72G/L98Q/Y105L IgV domain

<400>  3228

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3229
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V10A/G29W/T53S/M56K/L63P/L98Q/Y105L IgV domain

<400>  3229

His Val Ala Gln Pro Ala Ala Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3230
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 ECD

<400>  3230

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3231
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 ECD

<400>  3231

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp 
        115                 120                 125     


<210>  3232
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 IgV

<400>  3232

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3233
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD8B IgV

<400>  3233

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu 
            100                 105                 110     


<210>  3234
<211>  2580
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-CD3 - PD-L1 303 - PD-L1 303 - PD-L1 303 - Fc

<400>  3234
caggtccagc tgcagcagtc tggggctgaa ctggcaagac ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacctttact aggtacacga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac      180

aatcagaagt tcaaggacaa ggccacattg actacagaca aatcctccag cacagcctac      240

atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagatattat      300

gatgatcatt actgccttga ctactggggc caaggcacca cggtgaccgt gagcgccggg      360

ggaggtggca gcgggggagg tggcagcggc ggcgggagct cccaaattgt tctcacccag      420

tctccagcaa tcatgtctgc atctccaggg gagaaggtca ccatgacctg cagtgccagc      480

tcaagtgtaa gttacatgaa ctggtaccag cagaagtcag gcacctcccc caaaagatgg      540

atttatgaca catccaaact ggcttctgga gtccctgctc acttcagggg cagtgggtct      600

gggacctctt actctctcac aatcagcggc atggaggctg aagatgctgc cacttattac      660

tgccagcagt ggagtagtaa cccattcacg ttcggctcgg ggacaaagtt ggaaataaac      720

cggggcggtg gcgatcccgg tggaggaggg tcaagcgctt ttacagtaac cgtaccgaag      780

gacctttacg tcgttgagta tggatctaat atgactattg agtgtaaatt tcccgttgag      840

aaacagcttg acctggcggc gctcatcgtg tattgggaaa tggaagggaa agacattata      900

caattcgttc atggagagga agatcagaaa gcccaacact cttcttatcg acaaagggca      960

cggttgctga aagatcaatt gtcattggga aacgctgcat tgcaaattac tgacgtgaag     1020

ctccaggacg caggtgtata caggtgcatg attagttacg gtggaggagc ggactataag     1080

cggataaccg taaaggttaa cgcaggtggt ggagggtcag gcggaggagg atcttttacg     1140

gttacagtcc cgaaagacct ctatgtcgtc gaatacggat caaatatgac gatcgagtgc     1200

aaatttcctg tcgagaaaca gctggacctt gcggctttga tagtatactg ggagatggaa     1260

ggaaaggaca ttatccaatt cgtgcacggc gaagaggacc agaaggcgca acattcttca     1320

tacaggcagc gggctaggct tctcaaagat caattgagtc tcggcaacgc agcactgcaa     1380

attaccgatg tcaagttgca ggacgctggc gtctatcgct gcatgataag ctatggcggt     1440

ggtgcggact ataaacgaat tacggtgaag gtgaatgcag gtggcggcgg gagcggcggt     1500

ggagggagtt ttacagttac ggtcccaaag gatctttatg tggttgaata tggttcaaac     1560

atgaccatcg agtgtaagtt cccggtcgag aagcaactcg acttggctgc gttgattgta     1620

tactgggaga tggagggaaa ggacattatt cagtttgtcc atggggagga agatcaaaaa     1680

gctcagcaca gctcatatcg gcagcgggcc cgactgttga aagaccagtt gagtttgggg     1740

aacgcggctc ttcagataac tgatgttaag cttcaggacg caggagtgta taggtgcatg     1800

ataagttatg gcgggggagc cgattataaa cggataaccg taaaagttaa tgctggcggc     1860

ggaggttcag gcggaggtgg cagcgagccc aaaagctccg acaagactca cacatgcccc     1920

ccttgtccag cgcctgaagc tgagggtgcg ccctctgtct tccttttccc ccctaagccg     1980

aaagataccc tgatgatctc ccgcactccc gaagtcacat gtgttgttgt cgacgtatct     2040

catgaagatc ctgaggtgaa attcaactgg tatgtagacg gggtcgaagt tcataatgct     2100

aagactaagc cacgagaaga gcaatacaac tcaacgtatc gggtggtgag cgttctgacg     2160

gttctgcacc aagattggct taatggaaaa gagtataagt gcaaggtgtc caacaaggct     2220

cttccggcac ccatcgaaaa gacgatttcc aaagcgaaag gccaacctag ggaaccgcaa     2280

gtttacactt tgcccccgtc aagagacgaa cttaccaaga atcaagtttc cctgacgtgc     2340

cttgtgaagg gcttctaccc tagcgatata gcagttgagt gggaatctaa cggccagccc     2400

gaaaataatt ataagactac tccgcccgtg ctggacagtg atggttcatt tttcctgtat     2460

tcaaaactca ctgtggacaa atctagatgg cagcagggta atgtgttctc ttgttcagtt     2520

atgcacgagg cattgcacaa tcactatacg caaaaaagtt tgtctctctc tccggggaag     2580


<210>  3235
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL16 - PD-L1 303 - PD-L1 303 - PD-L1 303 - Fc

<400>  3235
agcgccgctt ctgcctcagc agccagcgat gtctctgtcg aaagcacggc ggaagctact       60

gtttgtactg tcacccttga gaaaatgagc gcgggtttgg ggttttcact cgagggcggc      120

aaagggtcac ttcacggcga caaaccattg acaatcaatc ggatatttaa aggtgctgcc      180

tctgaacaga gcgaaactgt tcaaccgggc gatgaaatac tgcaactggg tggtacagcc      240

atgcagggcc tgacgcgctt cgaggcgtgg aacattataa aagcactgcc tgatggtcca      300

gtcacaatag tcatccgccg gaaatcactt caatcaaagg agaccaccgc tgcgggagac      360

agcggtggag gagggtcaag cgcttttaca gtaaccgtac cgaaggacct ttacgtcgtt      420

gagtatggat ctaatatgac tattgagtgt aaatttcccg ttgagaaaca gcttgacctg      480

gcggcgctca tcgtgtattg ggaaatggaa gggaaagaca ttatacaatt cgttcatgga      540

gaggaagatc agaaagccca acactcttct tatcgacaaa gggcacggtt gctgaaagat      600

caattgtcat tgggaaacgc tgcattgcaa attactgacg tgaagctcca ggacgcaggt      660

gtatacaggt gcatgattag ttacggtgga ggagcggact ataagcggat aaccgtaaag      720

gttaacgcag gtggtggagg gtcaggcgga ggaggatctt ttacggttac agtcccgaaa      780

gacctctatg tcgtcgaata cggatcaaat atgacgatcg agtgcaaatt tcctgtcgag      840

aaacagctgg accttgcggc tttgatagta tactgggaga tggaaggaaa ggacattatc      900

caattcgtgc acggcgaaga ggaccagaag gcgcaacatt cttcatacag gcagcgggct      960

aggcttctca aagatcaatt gagtctcggc aacgcagcac tgcaaattac cgatgtcaag     1020

ttgcaggacg ctggcgtcta tcgctgcatg ataagctatg gcggtggtgc ggactataaa     1080

cgaattacgg tgaaggtgaa tgcaggtggc ggcgggagcg gcggtggagg gagttttaca     1140

gttacggtcc caaaggatct ttatgtggtt gaatatggtt caaacatgac catcgagtgt     1200

aagttcccgg tcgagaagca actcgacttg gctgcgttga ttgtatactg ggagatggag     1260

ggaaaggaca ttattcagtt tgtccatggg gaggaagatc aaaaagctca gcacagctca     1320

tatcggcagc gggcccgact gttgaaagac cagttgagtt tggggaacgc ggctcttcag     1380

ataactgatg ttaagcttca ggacgcagga gtgtataggt gcatgataag ttatggcggg     1440

ggagccgatt ataaacggat aaccgtaaaa gttaatgctg gcggcggagg ttcaggcgga     1500

ggtggcagcg agcccaaaag ctccgacaag actcacacat gccccccttg tccagcgcct     1560

gaagctgagg gtgcgccctc tgtcttcctt ttccccccta agccgaaaga taccctgatg     1620

atctcccgca ctcccgaagt cacatgtgtt gttgtcgacg tatctcatga agatcctgag     1680

gtgaaattca actggtatgt agacggggtc gaagttcata atgctaagac taagccacga     1740

gaagagcaat acaactcaac gtatcgggtg gtgagcgttc tgacggttct gcaccaagat     1800

tggcttaatg gaaaagagta taagtgcaag gtgtccaaca aggctcttcc ggcacccatc     1860

gaaaagacga tttccaaagc gaaaggccaa cctagggaac cgcaagttta cactttgccc     1920

ccgtcaagag acgaacttac caagaatcaa gtttccctga cgtgccttgt gaagggcttc     1980

taccctagcg atatagcagt tgagtgggaa tctaacggcc agcccgaaaa taattataag     2040

actactccgc ccgtgctgga cagtgatggt tcatttttcc tgtattcaaa actcactgtg     2100

gacaaatcta gatggcagca gggtaatgtg ttctcttgtt cagttatgca cgaggcattg     2160

cacaatcact atacgcaaaa aagtttgtct ctctctccgg ggaag                     2205


<210>  3236
<211>  2223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA-4 2519 - PD-L1 303 - PD-L1 303 - PD-L1 303 - Fc

<400>  3236
aaggcgatgc acgtagccca gcccgctgtt gttctcgcaa gttctcgcgg catagcctcc       60

ttcgtatgtg agtatgccag tccaggtaag tacacggagg tacgggtaac tgtactgcgg      120

caggccgatt cccaggttac ggaggtttgt gcggcaacct acatgatggg taacgagctt      180

acatttctcg acgactcaat atgtactggg acctcctcag gaaatcaggt caatctgacc      240

atccaaggtc tgagggcgat ggatacgggt ctttatattt gcaaggttga actcatgtat      300

ccgcctccat actatgaagg cattggaaat ggaacacaaa tctatgttat tgacccggag      360

ccgtgtccag atagtgatca gggtggagga gggtcaagcg cttttacagt aaccgtaccg      420

aaggaccttt acgtcgttga gtatggatct aatatgacta ttgagtgtaa atttcccgtt      480

gagaaacagc ttgacctggc ggcgctcatc gtgtattggg aaatggaagg gaaagacatt      540

atacaattcg ttcatggaga ggaagatcag aaagcccaac actcttctta tcgacaaagg      600

gcacggttgc tgaaagatca attgtcattg ggaaacgctg cattgcaaat tactgacgtg      660

aagctccagg acgcaggtgt atacaggtgc atgattagtt acggtggagg agcggactat      720

aagcggataa ccgtaaaggt taacgcaggt ggtggagggt caggcggagg aggatctttt      780

acggttacag tcccgaaaga cctctatgtc gtcgaatacg gatcaaatat gacgatcgag      840

tgcaaatttc ctgtcgagaa acagctggac cttgcggctt tgatagtata ctgggagatg      900

gaaggaaagg acattatcca attcgtgcac ggcgaagagg accagaaggc gcaacattct      960

tcatacaggc agcgggctag gcttctcaaa gatcaattga gtctcggcaa cgcagcactg     1020

caaattaccg atgtcaagtt gcaggacgct ggcgtctatc gctgcatgat aagctatggc     1080

ggtggtgcgg actataaacg aattacggtg aaggtgaatg caggtggcgg cgggagcggc     1140

ggtggaggga gttttacagt tacggtccca aaggatcttt atgtggttga atatggttca     1200

aacatgacca tcgagtgtaa gttcccggtc gagaagcaac tcgacttggc tgcgttgatt     1260

gtatactggg agatggaggg aaaggacatt attcagtttg tccatgggga ggaagatcaa     1320

aaagctcagc acagctcata tcggcagcgg gcccgactgt tgaaagacca gttgagtttg     1380

gggaacgcgg ctcttcagat aactgatgtt aagcttcagg acgcaggagt gtataggtgc     1440

atgataagtt atggcggggg agccgattat aaacggataa ccgtaaaagt taatgctggc     1500

ggcggaggtt caggcggagg tggcagcgag cccaaaagct ccgacaagac tcacacatgc     1560

cccccttgtc cagcgcctga agctgagggt gcgccctctg tcttcctttt cccccctaag     1620

ccgaaagata ccctgatgat ctcccgcact cccgaagtca catgtgttgt tgtcgacgta     1680

tctcatgaag atcctgaggt gaaattcaac tggtatgtag acggggtcga agttcataat     1740

gctaagacta agccacgaga agagcaatac aactcaacgt atcgggtggt gagcgttctg     1800

acggttctgc accaagattg gcttaatgga aaagagtata agtgcaaggt gtccaacaag     1860

gctcttccgg cacccatcga aaagacgatt tccaaagcga aaggccaacc tagggaaccg     1920

caagtttaca ctttgccccc gtcaagagac gaacttacca agaatcaagt ttccctgacg     1980

tgccttgtga agggcttcta ccctagcgat atagcagttg agtgggaatc taacggccag     2040

cccgaaaata attataagac tactccgccc gtgctggaca gtgatggttc atttttcctg     2100

tattcaaaac tcactgtgga caaatctaga tggcagcagg gtaatgtgtt ctcttgttca     2160

gttatgcacg aggcattgca caatcactat acgcaaaaaa gtttgtctct ctctccgggg     2220

aag                                                                   2223


<210>  3237
<211>  250
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  LFA-3

<400>  3237

Met Val Ala Gly Ser Asp Ala Gly Arg Ala Leu Gly Val Leu Ser Val 
1               5                   10                  15      


Val Cys Leu Leu His Cys Phe Gly Phe Ile Ser Cys Phe Ser Gln Gln 
            20                  25                  30          


Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His Val Pro Ser Asn 
        35                  40                  45              


Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys Asp Lys Val Ala 
    50                  55                  60                  


Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser Phe Lys Asn Arg 
65                  70                  75                  80  


Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr Asn Leu Thr 
                85                  90                  95      


Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn Ile Thr Asp 
            100                 105                 110         


Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Leu Pro Ser Pro Thr 
        115                 120                 125             


Leu Thr Cys Ala Leu Thr Asn Gly Ser Ile Glu Val Gln Cys Met Ile 
    130                 135                 140                 


Pro Glu His Tyr Asn Ser His Arg Gly Leu Ile Met Tyr Ser Trp Asp 
145                 150                 155                 160 


Cys Pro Met Glu Gln Cys Lys Arg Asn Ser Thr Ser Ile Tyr Phe Lys 
                165                 170                 175     


Met Glu Asn Asp Leu Pro Gln Lys Ile Gln Cys Thr Leu Ser Asn Pro 
            180                 185                 190         


Leu Phe Asn Thr Thr Ser Ser Ile Ile Leu Thr Thr Cys Ile Pro Ser 
        195                 200                 205             


Ser Gly His Ser Arg His Arg Tyr Ala Leu Ile Pro Ile Pro Leu Ala 
    210                 215                 220                 


Val Ile Thr Thr Cys Ile Val Leu Tyr Met Asn Gly Ile Leu Lys Cys 
225                 230                 235                 240 


Asp Arg Lys Pro Asp Arg Thr Asn Ser Asn 
                245                 250 


<210>  3238
<211>  222
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature LFA-3

<400>  3238

Phe Ser Gln Gln Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His 
1               5                   10                  15      


Val Pro Ser Asn Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys 
            20                  25                  30          


Asp Lys Val Ala Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser 
        35                  40                  45              


Phe Lys Asn Arg Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile 
    50                  55                  60                  


Tyr Asn Leu Thr Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro 
65                  70                  75                  80  


Asn Ile Thr Asp Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Leu 
                85                  90                  95      


Pro Ser Pro Thr Leu Thr Cys Ala Leu Thr Asn Gly Ser Ile Glu Val 
            100                 105                 110         


Gln Cys Met Ile Pro Glu His Tyr Asn Ser His Arg Gly Leu Ile Met 
        115                 120                 125             


Tyr Ser Trp Asp Cys Pro Met Glu Gln Cys Lys Arg Asn Ser Thr Ser 
    130                 135                 140                 


Ile Tyr Phe Lys Met Glu Asn Asp Leu Pro Gln Lys Ile Gln Cys Thr 
145                 150                 155                 160 


Leu Ser Asn Pro Leu Phe Asn Thr Thr Ser Ser Ile Ile Leu Thr Thr 
                165                 170                 175     


Cys Ile Pro Ser Ser Gly His Ser Arg His Arg Tyr Ala Leu Ile Pro 
            180                 185                 190         


Ile Pro Leu Ala Val Ile Thr Thr Cys Ile Val Leu Tyr Met Asn Gly 
        195                 200                 205             


Ile Leu Lys Cys Asp Arg Lys Pro Asp Arg Thr Asn Ser Asn 
    210                 215                 220         


<210>  3239
<211>  187
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  LFA-3 ECD

<400>  3239

Phe Ser Gln Gln Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His 
1               5                   10                  15      


Val Pro Ser Asn Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys 
            20                  25                  30          


Asp Lys Val Ala Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser 
        35                  40                  45              


Phe Lys Asn Arg Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile 
    50                  55                  60                  


Tyr Asn Leu Thr Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro 
65                  70                  75                  80  


Asn Ile Thr Asp Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Leu 
                85                  90                  95      


Pro Ser Pro Thr Leu Thr Cys Ala Leu Thr Asn Gly Ser Ile Glu Val 
            100                 105                 110         


Gln Cys Met Ile Pro Glu His Tyr Asn Ser His Arg Gly Leu Ile Met 
        115                 120                 125             


Tyr Ser Trp Asp Cys Pro Met Glu Gln Cys Lys Arg Asn Ser Thr Ser 
    130                 135                 140                 


Ile Tyr Phe Lys Met Glu Asn Asp Leu Pro Gln Lys Ile Gln Cys Thr 
145                 150                 155                 160 


Leu Ser Asn Pro Leu Phe Asn Thr Thr Ser Ser Ile Ile Leu Thr Thr 
                165                 170                 175     


Cys Ile Pro Ser Ser Gly His Ser Arg His Arg 
            180                 185         


<210>  3240
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EAAAK Linker

<400>  3240

Glu Ala Ala Ala Lys 
1               5   


<210>  3241
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3x EAAAK Linker

<400>  3241

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  3242
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5x EAAAK Linker

<400>  3242

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25  


<210>  3243
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  eGFP

<400>  3243

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  3244
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v1 ECD

<400>  3244

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3245
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v2 ECD

<400>  3245

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3246
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v3 ECD

<400>  3246

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ala Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3247
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v4 ECD

<400>  3247

Val Ile His Met Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3248
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v5 ECD

<400>  3248

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3249
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v6 ECD

<400>  3249

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Leu Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ser Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3250
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v7 ECD

<400>  3250

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Pro Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3251
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v8 ECD

<400>  3251

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Gly Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3252
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v9 ECD

<400>  3252

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3253
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v10 ECD

<400>  3253

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3254
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v11 ECD

<400>  3254

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Ala Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3255
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v12 ECD

<400>  3255

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Asn Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3256
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v13 ECD

<400>  3256

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Ser Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Lys His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3257
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v14 ECD

<400>  3257

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Ser Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3258
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v15 ECD

<400>  3258

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Glu Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Thr Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Thr Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3259
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v16 ECD

<400>  3259

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Gly Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3260
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v17 ECD

<400>  3260

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Ser Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3261
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v18 ECD

<400>  3261

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Pro Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3262
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v19 ECD

<400>  3262

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Glu Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3263
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v20 ECD

<400>  3263

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3264
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v21 ECD

<400>  3264

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Val Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3265
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v22 ECD

<400>  3265

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Met Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3266
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v23 ECD

<400>  3266

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Thr Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Gly Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Thr Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3267
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v24 ECD

<400>  3267

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr His Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Gly Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Gly Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3268
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v25 ECD

<400>  3268

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Gly Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3269
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v26 ECD

<400>  3269

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Ala Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Ala Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3270
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v27 ECD

<400>  3270

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu His Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Ala Pro Ser 
            100                 105                 110         


Ile Ser Asp Leu Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3271
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v28 ECD

<400>  3271

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr His Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Gly Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3272
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v29 ECD

<400>  3272

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Ser Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3273
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v30 ECD

<400>  3273

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Thr Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3274
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v31 ECD

<400>  3274

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Ala Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3275
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v32 ECD

<400>  3275

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Val Val Leu Asp Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Gly Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Gly Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Ala Val Leu Lys Tyr Glu Glu Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3276
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v33 ECD

<400>  3276

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Pro Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3277
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v34 ECD

<400>  3277

Val Ile His Val Thr Lys Glu Val Lys Glu Val Val Thr Leu Phe Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Gly Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Leu His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Thr Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3278
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v35 ECD

<400>  3278

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Phe Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Gly Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3279
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v36 ECD

<400>  3279

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Gly Pro Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3280
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v37 ECD

<400>  3280

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Leu Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Leu Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3281
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v38 ECD

<400>  3281

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3282
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v39 ECD

<400>  3282

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Ser 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3283
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v40 ECD

<400>  3283

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Thr Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Ser Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3284
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v41 ECD

<400>  3284

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Gly Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Leu Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu Arg 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Ser Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3285
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v42 ECD

<400>  3285

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3286
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v43 ECD

<400>  3286

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Val Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Gln Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Arg Cys Val Val Ile Lys Tyr Glu Arg Leu Glu Asn Gln Gly Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3287
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v44 ECD

<400>  3287

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Ile Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3288
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v45 ECD

<400>  3288

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Arg Lys Gly Tyr Arg Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Ser Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Ser His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3289
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v46 ECD

<400>  3289

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Arg Lys Gly Tyr Arg Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3290
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v47 ECD

<400>  3290

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Gly Gln Ile Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Leu Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Gly Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3291
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v48 ECD

<400>  3291

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Asp Arg Lys Gly Tyr Arg Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3292
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v49 ECD

<400>  3292

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Gly Gln Ile Val Met Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3293
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v50 ECD

<400>  3293

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Gly Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3294
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v51 ECD

<400>  3294

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr His Ile His Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Gly Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Asn Gly Glu Asn Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Ser Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3295
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v52 ECD

<400>  3295

Val Ile His Val Thr Lys Glu Val Lys Glu Val Thr Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Val Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Leu Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Lys Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Ser Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3296
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v53 ECD

<400>  3296

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Val Ile Phe Trp 
            20                  25                  30          


Gln Lys Glu Gly Lys Leu Val Leu Thr Met Gln Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Arg Cys Ile Val Ile Lys Tyr Glu Arg Leu Glu Asn Gln Gly Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3297
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v54 ECD

<400>  3297

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Pro Ala Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Glu Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3298
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 WT IgV

<400>  3298

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3299
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v1 IgV

<400>  3299

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3300
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v20 IgV

<400>  3300

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3301
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v6 IgV

<400>  3301

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Leu Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ser Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3302
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v7 IgV

<400>  3302

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Pro Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3303
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v9 IgV

<400>  3303

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3304
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v10 IgV

<400>  3304

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3305
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v11 IgV

<400>  3305

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Ala Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3306
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v12 IgV

<400>  3306

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Asn Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3307
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v13 IgV

<400>  3307

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Ser Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Lys His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3308
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v14 IgV

<400>  3308

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Ser Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3309
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v15 IgV

<400>  3309

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Glu Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Thr Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3310
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v16 IgV

<400>  3310

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Gly Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3311
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v17 IgV

<400>  3311

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Ser Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3312
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v19 IgV

<400>  3312

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Glu Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3313
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v21 IgV

<400>  3313

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Val Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3314
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v22 IgV

<400>  3314

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Met Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3315
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v23 IgV

<400>  3315

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Thr Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Gly Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3316
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v24 IgV

<400>  3316

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr His Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Gly Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Gly Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3317
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v25 IgV

<400>  3317

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Gly Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3318
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v26 IgV

<400>  3318

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Ala Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3319
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v27 IgV

<400>  3319

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu His Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3320
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v28 IgV

<400>  3320

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr His Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Gly Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3321
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v30 IgV

<400>  3321

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Thr Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3322
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v32 IgV

<400>  3322

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Val Val Leu Asp Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Gly Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Gly Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Ala Val Leu Lys Tyr Glu Glu Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3323
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v33 IgV

<400>  3323

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3324
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v34 IgV

<400>  3324

Val Ile His Val Thr Lys Glu Val Lys Glu Val Val Thr Leu Phe Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Gly Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3325
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v35 IgV

<400>  3325

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Phe Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Gly Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3326
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v36 IgV

<400>  3326

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Gly Pro Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3327
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v37 IgV

<400>  3327

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Leu Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3328
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v38 IgV

<400>  3328

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3329
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v40 IgV

<400>  3329

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Thr Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3330
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v41 IgV

<400>  3330

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Gly Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Leu Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu Arg 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3331
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v43 IgV

<400>  3331

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Val Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Gln Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Arg Cys Val Val Ile Lys Tyr Glu Arg Leu Glu Asn Gln Gly Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3332
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v44 IgV

<400>  3332

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Ile Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3333
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v45 IgV

<400>  3333

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Arg Lys Gly Tyr Arg Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3334
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v47 IgV

<400>  3334

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Gly Gln Ile Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Leu Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Gly Val Thr 
            100     


<210>  3335
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v48 IgV

<400>  3335

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Asp Arg Lys Gly Tyr Arg Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3336
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v49 IgV

<400>  3336

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Gly Gln Ile Val Met Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3337
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v50 IgV

<400>  3337

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Gly Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3338
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v51 IgV

<400>  3338

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr His Ile His Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Gly Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Asn Gly Glu Asn Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3339
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v52 IgV

<400>  3339

Val Ile His Val Thr Lys Glu Val Lys Glu Val Thr Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Val Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Leu Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Lys Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3340
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v53 IgV

<400>  3340

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Val Ile Phe Trp 
            20                  25                  30          


Gln Lys Glu Gly Lys Leu Val Leu Thr Met Gln Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Arg Cys Ile Val Ile Lys Tyr Glu Arg Leu Glu Asn Gln Gly Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3341
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v54 IgV

<400>  3341

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Pro Ala Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Glu Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3342
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v55 ECD

<400>  3342

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3343
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v56 ECD

<400>  3343

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3344
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v57 ECD

<400>  3344

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3345
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v58 ECD

<400>  3345

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Arg Val Leu Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Thr Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3346
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v59 ECD

<400>  3346

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Leu Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3347
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v60 ECD

<400>  3347

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Arg Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Glu Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3348
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v61 ECD

<400>  3348

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Gly Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Val Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3349
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v62 ECD

<400>  3349

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3350
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v63 ECD

<400>  3350

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3351
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v64 ECD

<400>  3351

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3352
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v65 ECD

<400>  3352

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3353
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v66ECD

<400>  3353

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3354
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v67 ECD

<400>  3354

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Leu Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3355
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v68 ECD

<400>  3355

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3356
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v69 ECD

<400>  3356

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3357
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v70 ECD

<400>  3357

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3358
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v71 ECD

<400>  3358

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Tyr 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3359
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v72 ECD

<400>  3359

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Phe Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3360
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v73 ECD

<400>  3360

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3361
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v74 ECD

<400>  3361

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3362
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v75 ECD

<400>  3362

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Ile Leu Glu His 
                85                  90                  95      


Arg Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3363
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v76 ECD

<400>  3363

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Ile Leu Glu His 
                85                  90                  95      


Arg Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Ser Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3364
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v77 ECD

<400>  3364

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3365
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v78 ECD

<400>  3365

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Asn Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Phe Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Ala Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3366
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v79 ECD

<400>  3366

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Ala Pro Val Phe Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3367
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v80 ECD

<400>  3367

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Ala Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3368
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v81 ECD

<400>  3368

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Ser Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3369
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v82 ECD

<400>  3369

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Ser Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3370
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v83 ECD

<400>  3370

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Ser 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Ala Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3371
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v84 ECD

<400>  3371

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3372
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v85 ECD

<400>  3372

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Gly Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Leu Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3373
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v86 ECD

<400>  3373

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn Ile 
        35                  40                  45              


Trp Pro Glu Cys Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn Leu 
    50                  55                  60                  


Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr Glu 
65                  70                  75                  80  


Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His Leu 
                85                  90                  95      


Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser Ile 
            100                 105                 110         


Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys Ser 
        115                 120                 125             


Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn Gly 
    130                 135                 140                 


Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu Thr 
145                 150                 155                 160 


Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr Asn 
                165                 170                 175     


His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn Gln 
            180                 185                 190         


Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205         


<210>  3374
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v87 ECD

<400>  3374

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3375
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v88 ECD

<400>  3375

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Leu Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3376
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v89 ECD

<400>  3376

Val Ile His Val Thr Lys Glu Val Glu Arg Ser Gly Asn Ala Val Leu 
1               5                   10                  15      


Trp Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Cys Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asp Ala Ile Thr Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3377
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v90 ECD

<400>  3377

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Met Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3378
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v91 ECD

<400>  3378

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Glu Asp Ala Phe Glu Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3379
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v92 ECD

<400>  3379

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Pro Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Ile 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Ala Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe His Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Leu Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Ile Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3380
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v93 ECD

<400>  3380

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Leu Ser Asp Glu Gly Thr Asn 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Arg Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3381
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v94 ECD

<400>  3381

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Pro Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Leu Ser Asp Glu Gly Thr Asn 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asn Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Gly Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3382
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v95 ECD

<400>  3382

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3383
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v96 ECD

<400>  3383

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Ser Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3384
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v97 ECD

<400>  3384

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Leu Ser Asp Glu Gly Thr Asn 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Ser Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3385
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v98 ECD

<400>  3385

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Gly 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Gly Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Thr Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Ile Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn Arg Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asp 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3386
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v99 ECD

<400>  3386

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Phe Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Val Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Gly Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Gln Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3387
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v100 ECD

<400>  3387

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3388
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v101 ECD

<400>  3388

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Ser 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Phe Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Ile Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3389
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v102 ECD

<400>  3389

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Gly Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Asp Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3390
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v103 ECD

<400>  3390

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Pro Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3391
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v104 ECD

<400>  3391

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Pro Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3392
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v105 ECD

<400>  3392

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Thr Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3393
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v106 ECD

<400>  3393

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Pro Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3394
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v107 ECD

<400>  3394

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Ala Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3395
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v108 ECD

<400>  3395

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Arg Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Gln Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3396
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v109 ECD

<400>  3396

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Arg Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3397
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v110 ECD

<400>  3397

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Ala Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Ile Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3398
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v111 ECD

<400>  3398

Val Ile His Val Thr Lys Glu Val Lys Glu Val Gly Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Ala Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Arg Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys His Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3399
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v112 ECD

<400>  3399

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Thr Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Ser Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3400
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v113 ECD

<400>  3400

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Ile Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Leu Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3401
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v114 ECD

<400>  3401

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3402
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v115 ECD

<400>  3402

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3403
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v116 ECD

<400>  3403

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Ile Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3404
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v117 ECD

<400>  3404

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Phe Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Ile Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3405
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v118 ECD

<400>  3405

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Arg 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3406
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v119 ECD

<400>  3406

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Arg Thr Cys Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Thr Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Pro Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Gly 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3407
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v120 ECD

<400>  3407

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Pro Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Ala Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3408
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v121 ECD

<400>  3408

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Pro Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3409
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v93 IgV

<400>  3409

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Leu Ser Asp Glu Gly Thr Asn 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Arg Ala Glu Val Thr 
            100     


<210>  3410
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v122 ECD

<400>  3410

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asp 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3411
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v123 ECD

<400>  3411

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ala Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3412
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v124 ECD

<400>  3412

Val Ile His Met Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3413
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v125 ECD

<400>  3413

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3414
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v126 ECD

<400>  3414

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Ser 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3415
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v127 ECD

<400>  3415

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Leu Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3416
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v128 ECD

<400>  3416

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Gly Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3417
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v129 ECD

<400>  3417

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3418
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v130 ECD

<400>  3418

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Ser Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3419
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v131 ECD

<400>  3419

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Ala Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3420
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v132 ECD

<400>  3420

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Ser Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Lys His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Val Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Asn Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3421
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v133 ECD

<400>  3421

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Ser Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Thr Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3422
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v134 ECD

<400>  3422

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Glu Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Thr Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Thr Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3423
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v135 ECD

<400>  3423

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Gly Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asn Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3424
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v136 ECD

<400>  3424

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Ser Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Glu Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3425
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v137 ECD

<400>  3425

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Val Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3426
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v138 ECD

<400>  3426

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Met Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu His Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3427
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v139 ECD

<400>  3427

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Thr Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Gly Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Thr Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3428
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v140 ECD

<400>  3428

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Gly Met Leu Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Val Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3429
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v141 ECD

<400>  3429

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


His Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Ala Pro Ser 
            100                 105                 110         


Ile Ser Asp Leu Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3430
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v142 ECD

<400>  3430

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr His Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Gly Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3431
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v143 ECD

<400>  3431

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr His Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Gly Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3432
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v144 ECD

<400>  3432

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Thr Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe His Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3433
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v145 ECD

<400>  3433

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Ala Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3434
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v146 ECD

<400>  3434

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Val Val Leu Asp Met Ile Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Gly Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Gly Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Ala Val Leu Lys Tyr Glu Glu Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Val Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3435
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v147 ECD

<400>  3435

Val Ile His Val Thr Lys Glu Val Lys Glu Val Val Thr Leu Phe Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Leu Val Leu Gly Met Leu Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Leu His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asp Ala Ile Thr Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3436
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v148 ECD

<400>  3436

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Phe Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Gly Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3437
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v149 ECD

<400>  3437

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Gly Pro Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Thr Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3438
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v150 ECD

<400>  3438

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Leu Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Leu Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3439
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v151 ECD

<400>  3439

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Asp Arg Lys Gly Tyr Arg Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Ser Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Ser His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3440
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v152 ECD

<400>  3440

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Gly Gln Ile Val Met Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Leu Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Gly Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3441
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v153 ECD

<400>  3441

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Gly Lys Met Val Met Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3442
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v154 ECD

<400>  3442

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3443
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v155 ECD

<400>  3443

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3444
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v156 ECD

<400>  3444

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3445
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v157 ECD

<400>  3445

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Thr Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3446
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v158 ECD

<400>  3446

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asp 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Leu Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3447
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v159 ECD

<400>  3447

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Arg Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Glu Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3448
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v160 ECD

<400>  3448

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Gly Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Val Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3449
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v161 ECD

<400>  3449

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Val Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3450
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v162 ECD

<400>  3450

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3451
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v163 ECD

<400>  3451

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3452
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v164 ECD

<400>  3452

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Leu Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3453
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v165 ECD

<400>  3453

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3454
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v166 ECD

<400>  3454

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Leu Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3455
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v167 ECD

<400>  3455

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asp Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3456
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v168 ECD

<400>  3456

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3457
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v169 ECD

<400>  3457

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Tyr 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3458
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v170 ECD

<400>  3458

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Asp Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3459
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v171 ECD

<400>  3459

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3460
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v172 ECD

<400>  3460

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Asn Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Phe Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Ala Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Val Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3461
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v173 ECD

<400>  3461

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Phe Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3462
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v174 ECD

<400>  3462

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Ala Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3463
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v175 ECD

<400>  3463

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Ser Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3464
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v176 ECD

<400>  3464

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Ser 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Ala Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3465
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v177 ECD

<400>  3465

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3466
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v178 ECD

<400>  3466

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Gly Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Leu Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3467
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v179 ECD

<400>  3467

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Cys Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3468
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v180 ECD

<400>  3468

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Glu Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3469
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v181 ECD

<400>  3469

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Cys Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asp Ala Ile Thr Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3470
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v182 ECD

<400>  3470

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Val Pro Ser Ser Asn Ile Arg Arg Ile Thr Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly Asp Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3471
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v183 ECD

<400>  3471

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Ala Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  3472
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v153 IgV

<400>  3472

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Gly Lys Met Val Met Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  3473
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v153 IgV

<400>  3473

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Gly Lys Met Val Met Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3474
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 trailing sequence

<400>  3474

Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser Ile Ser Asp Phe Glu 
1               5                   10                  15      


Ile Pro 
        


<210>  3475
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD80 IgV wildtype

<400>  3475

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3476
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v46 IgV

<400>  3476

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Arg Lys Gly Tyr Arg Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3477
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v1 IgV

<400>  3477

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3478
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v20 IgV

<400>  3478

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3479
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v43 IgV

<400>  3479

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Val Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Gln Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Arg Cys Val Val Ile Lys Tyr Glu Arg Leu Glu Asn Gln Gly Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3480
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v44 IgV

<400>  3480

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Ile Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3481
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v18 IgV

<400>  3481

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Pro Val Lys Ala Asp 
            100                 105         


<210>  3482
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v48 IgV

<400>  3482

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Asp Arg Lys Gly Tyr Arg Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3483
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v49 IgV

<400>  3483

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Gly Gln Ile Val Met Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3484
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v50 IgV

<400>  3484

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Gly Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3485
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v53 IgV

<400>  3485

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Val Ile Phe Trp 
            20                  25                  30          


Gln Lys Glu Gly Lys Leu Val Leu Thr Met Gln Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Arg Cys Ile Val Ile Lys Tyr Glu Arg Leu Glu Asn Gln Gly Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3486
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v54 IgV

<400>  3486

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Met Ile Pro Ala Pro Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Glu Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3487
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v93 IgV

<400>  3487

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Asp Ile Leu Trp 
            20                  25                  30          


His Lys Glu Gly Lys Ile Val Leu Ala Met Arg Ser Gly Asp Thr Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Leu Ser Asp Glu Gly Thr Asn 
65                  70                  75                  80  


Val Cys Val Val Arg Lys Tyr Glu Asn Asp Thr Pro Val Leu Glu His 
                85                  90                  95      


Arg Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3488
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v19 IgV

<400>  3488

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Glu Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3489
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 v29 IgV

<400>  3489

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Ser Ser Val Lys Ala Asp 
            100                 105         


<210>  3490
<211>  100
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD4 IgV

<400>  3490

Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys 
1               5                   10                  15      


Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn 
            20                  25                  30          


Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro 
        35                  40                  45              


Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln 
    50                  55                  60                  


Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp 
65                  70                  75                  80  


Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu 
                85                  90                  95      


Val Phe Gly Leu 
            100 


<210>  3491
<211>  114
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD8A IgV

<400>  3491

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala 
        


<210>  3492
<211>  131
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  LAG3 IgV

<400>  3492

Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile Pro Leu Gln Asp 
1               5                   10                  15      


Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln His Gln Pro Asp 
            20                  25                  30          


Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu Ala Pro Gly Pro 
        35                  40                  45              


His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro Arg Arg Tyr Thr 
    50                  55                  60                  


Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly Arg Leu Pro Leu 
65                  70                  75                  80  


Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln Arg Gly Asp Phe 
                85                  90                  95      


Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala Gly Glu Tyr Arg 
            100                 105                 110         


Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys Arg Leu Arg Leu 
        115                 120                 125             


Arg Leu Gly 
    130     


<210>  3493
<211>  243
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD48

<400>  3493

Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Thr Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Thr 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Thr Leu Ala Arg Ser Phe Gly Val Glu 
    210                 215                 220                 


Trp Ile Ala Ser Trp Leu Val Val Thr Val Pro Thr Ile Leu Gly Leu 
225                 230                 235                 240 


Leu Leu Thr 
            


<210>  3494
<211>  194
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD48 ECD

<400>  3494

Gln Gly His Leu Val His Met Thr Val Val Ser Gly Ser Asn Val Thr 
1               5                   10                  15      


Leu Asn Ile Ser Glu Ser Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp 
            20                  25                  30          


Phe Tyr Thr Phe Asp Gln Lys Ile Val Glu Trp Asp Ser Arg Lys Ser 
        35                  40                  45              


Lys Tyr Phe Glu Ser Lys Phe Lys Gly Arg Val Arg Leu Asp Pro Gln 
    50                  55                  60                  


Ser Gly Ala Leu Tyr Ile Ser Lys Val Gln Lys Glu Asp Asn Ser Thr 
65                  70                  75                  80  


Tyr Ile Met Arg Val Leu Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys 
                85                  90                  95      


Ile Lys Leu Gln Val Leu Asp Pro Val Pro Lys Pro Val Ile Lys Ile 
            100                 105                 110         


Glu Lys Ile Glu Asp Met Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys 
        115                 120                 125             


Val Ile Pro Gly Glu Ser Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg 
    130                 135                 140                 


Pro Phe Pro Lys Glu Leu Gln Asn Ser Val Leu Glu Thr Thr Leu Met 
145                 150                 155                 160 


Pro His Asn Tyr Ser Arg Cys Tyr Thr Cys Gln Val Ser Asn Ser Val 
                165                 170                 175     


Ser Ser Lys Asn Gly Thr Val Cys Leu Ser Pro Pro Cys Thr Leu Ala 
            180                 185                 190         


Arg Ser 
        


<210>  3495
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 wt ECD

<400>  3495

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp Gln 
        115                 120                 125         


<210>  3496
<211>  266
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - ICOSL 2264

<400>  3496

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
    130                 135                 140                 


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
145                 150                 155                 160 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
                165                 170                 175     


Tyr His Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr 
            180                 185                 190         


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
        195                 200                 205             


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
    210                 215                 220                 


Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
225                 230                 235                 240 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Asp Tyr Lys Asp 
                245                 250                 255     


Asp Asp Asp Lys His His His His His His 
            260                 265     


<210>  3497
<211>  266
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - ICOSL 2266

<400>  3497

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
    130                 135                 140                 


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
145                 150                 155                 160 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
                165                 170                 175     


Tyr His Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
            180                 185                 190         


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
        195                 200                 205             


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
    210                 215                 220                 


Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
225                 230                 235                 240 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Asp Tyr Lys Asp 
                245                 250                 255     


Asp Asp Asp Lys His His His His His His 
            260                 265     


<210>  3498
<211>  253
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L2 1417 -ICOSL 2266

<400>  3498

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val 
        115                 120                 125             


Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe 
    130                 135                 140                 


Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr 
145                 150                 155                 160 


Val Val Thr Tyr His Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp 
                165                 170                 175     


Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg 
            180                 185                 190         


Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln 
        195                 200                 205             


Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val 
    210                 215                 220                 


Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250             


<210>  3499
<211>  253
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L2 1417 - ICOSL 2264:

<400>  3499

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val 
        115                 120                 125             


Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe 
    130                 135                 140                 


Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr 
145                 150                 155                 160 


Val Val Thr Tyr His Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp 
                165                 170                 175     


Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg 
            180                 185                 190         


Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln 
        195                 200                 205             


Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val 
    210                 215                 220                 


Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250             


<210>  3500
<211>  533
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 -PD-L1 303 - ICOSL 2264 -ICOSL 2264

<400>  3500

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
    130                 135                 140                 


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
145                 150                 155                 160 


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile 
                165                 170                 175     


Ile Gln Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser 
            180                 185                 190         


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
        195                 200                 205             


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
    210                 215                 220                 


Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr 
225                 230                 235                 240 


Val Lys Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly 
            260                 265                 270         


Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp 
        275                 280                 285             


Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val 
    290                 295                 300                 


Val Thr Tyr His Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser 
305                 310                 315                 320 


Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly 
                325                 330                 335     


Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys 
            340                 345                 350         


Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu 
        355                 360                 365             


Ser Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln 
385                 390                 395                 400 


Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys 
                405                 410                 415     


Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr 
            420                 425                 430         


Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln 
        435                 440                 445             


His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu 
    450                 455                 460                 


Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe 
465                 470                 475                 480 


Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser 
                485                 490                 495     


Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His 
            500                 505                 510         


Val Ala Ala Asn Phe Ser Val Asp Tyr Lys Asp Asp Asp Asp Lys His 
        515                 520                 525             


His His His His His 
    530             


<210>  3501
<211>  396
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - ICOSL 2264  - PD-L1 303

<400>  3501

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
    130                 135                 140                 


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
145                 150                 155                 160 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
                165                 170                 175     


Tyr His Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr 
            180                 185                 190         


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
        195                 200                 205             


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
    210                 215                 220                 


Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
225                 230                 235                 240 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val 
            260                 265                 270         


Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
        275                 280                 285             


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
    290                 295                 300                 


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
305                 310                 315                 320 


Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
                325                 330                 335     


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
            340                 345                 350         


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
        355                 360                 365             


Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Asp Tyr 
    370                 375                 380                 


Lys Asp Asp Asp Asp Lys His His His His His His 
385                 390                 395     


<210>  3502
<211>  533
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303  - ICOSL 2264 - ICOSL 2264  - PD-L1 303

<400>  3502

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
    130                 135                 140                 


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
145                 150                 155                 160 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
                165                 170                 175     


Tyr His Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr 
            180                 185                 190         


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
        195                 200                 205             


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
    210                 215                 220                 


Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
225                 230                 235                 240 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys 
            260                 265                 270         


Glu Val Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys 
        275                 280                 285             


Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln 
    290                 295                 300                 


Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln His Ser 
305                 310                 315                 320 


Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser 
                325                 330                 335     


Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val 
            340                 345                 350         


Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser 
        355                 360                 365             


Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala 
    370                 375                 380                 


Ala Asn Phe Ser Val Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val 
                405                 410                 415     


Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys 
            420                 425                 430         


Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys 
        435                 440                 445             


Asp Ile Ile Gln Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His 
    450                 455                 460                 


Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu 
465                 470                 475                 480 


Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly 
                485                 490                 495     


Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg 
            500                 505                 510         


Ile Thr Val Lys Val Asn Ala Asp Tyr Lys Asp Asp Asp Asp Lys His 
        515                 520                 525             


His His His His His 
    530             


<210>  3503
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Moiety: COMP

<400>  3503

Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala 
1               5                   10                  15      


Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr 
            20                  25                  30          


Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala Cys Gly 
        35                  40                  45  


<210>  3504
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Moiety: VASP

<400>  3504

Asp Leu Gln Arg Val Lys Gln Glu Leu Leu Glu Glu Val Lys Lys Glu 
1               5                   10                  15      


Leu Gln Lys Val Lys Glu Glu Ile Ile Glu Ala Phe Val Gln Glu Leu 
            20                  25                  30          


Arg 
    


<210>  3505
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Moiety: ZZ12.6

<400>  3505

Asp Val Gln Ala Ile Ser Ser Thr Ile Gln Asp Leu Gln Asp Gln Val 
1               5                   10                  15      


Asp Ser Leu Ala Glu Val Val Leu Gln Asn Arg Arg Gly Leu Asp Leu 
            20                  25                  30          


Leu Thr Arg Ser Gly Gly Gly Ser 
        35                  40  


<210>  3506
<211>  189
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - COMP

<400>  3506

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn 
    130                 135                 140                 


Ala Ala Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val Arg Glu 
145                 150                 155                 160 


Ile Thr Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala Cys Gly Asp 
                165                 170                 175     


Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
            180                 185                 


<210>  3507
<211>  326
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - ICOSL 2264 - COMP

<400>  3507

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
    130                 135                 140                 


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
145                 150                 155                 160 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
                165                 170                 175     


Tyr His Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr 
            180                 185                 190         


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
        195                 200                 205             


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
    210                 215                 220                 


Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
225                 230                 235                 240 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Leu Gly Pro Gln 
            260                 265                 270         


Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val Arg 
        275                 280                 285             


Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn Thr 
    290                 295                 300                 


Val Met Glu Cys Asp Ala Cys Gly Asp Tyr Lys Asp Asp Asp Asp Lys 
305                 310                 315                 320 


His His His His His His 
                325     


<210>  3508
<211>  177
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - VASP

<400>  3508

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Leu Gln Arg Val Lys Gln Glu Leu Leu Glu Glu Val Lys 
    130                 135                 140                 


Lys Glu Leu Gln Lys Val Lys Glu Glu Ile Ile Glu Ala Phe Val Gln 
145                 150                 155                 160 


Glu Leu Arg Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His 
                165                 170                 175     


His 
    


<210>  3509
<211>  314
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - ICOSL 2264 - VASP

<400>  3509

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
    130                 135                 140                 


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
145                 150                 155                 160 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
                165                 170                 175     


Tyr His Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr 
            180                 185                 190         


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
        195                 200                 205             


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
    210                 215                 220                 


Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
225                 230                 235                 240 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Leu Gln Arg Val 
            260                 265                 270         


Lys Gln Glu Leu Leu Glu Glu Val Lys Lys Glu Leu Gln Lys Val Lys 
        275                 280                 285             


Glu Glu Ile Ile Glu Ala Phe Val Gln Glu Leu Arg Asp Tyr Lys Asp 
    290                 295                 300                 


Asp Asp Asp Lys His His His His His His 
305                 310                 


<210>  3510
<211>  175
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ZZ12.6 - PD-L1 303

<400>  3510

Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His Gly Gly 
1               5                   10                  15      


Gly Gly Ser Ser Asp Val Gln Ala Ile Ser Ser Thr Ile Gln Asp Leu 
            20                  25                  30          


Gln Asp Gln Val Asp Ser Leu Ala Glu Val Val Leu Gln Asn Arg Arg 
        35                  40                  45              


Gly Leu Asp Leu Leu Thr Arg Ser Gly Gly Gly Ser Phe Thr Val Thr 
    50                  55                  60                  


Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile 
65                  70                  75                  80  


Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile 
                85                  90                  95      


Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly 
            100                 105                 110         


Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg 
        115                 120                 125             


Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr 
    130                 135                 140                 


Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr 
145                 150                 155                 160 


Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala 
                165                 170                 175 


<210>  3511
<211>  184
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - ZZ12.6

<400>  3511

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Ala Ile Ser Ser Thr Ile Gln Asp Leu Gln Asp 
    130                 135                 140                 


Gln Val Asp Ser Leu Ala Glu Val Val Leu Gln Asn Arg Arg Gly Leu 
145                 150                 155                 160 


Asp Leu Leu Thr Arg Ser Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp 
                165                 170                 175     


Asp Lys His His His His His His 
            180                 


<210>  3512
<211>  354
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L2 1417  - Fc

<400>  3512

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
        115                 120                 125             


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
    130                 135                 140                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
145                 150                 155                 160 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                165                 170                 175     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            180                 185                 190         


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
        195                 200                 205             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    210                 215                 220                 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
225                 230                 235                 240 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser 
                245                 250                 255     


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
            260                 265                 270         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        275                 280                 285             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    290                 295                 300                 


Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
305                 310                 315                 320 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                325                 330                 335     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly His His His His 
            340                 345                 350         


His His 
        


<210>  3513
<211>  497
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303  - ICOSL 2266 - Fc

<400>  3513

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser 
    130                 135                 140                 


Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu 
145                 150                 155                 160 


Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val 
                165                 170                 175     


Thr Tyr His Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg 
            180                 185                 190         


Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp 
        195                 200                 205             


Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe 
    210                 215                 220                 


His Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser 
225                 230                 235                 240 


Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys 
            260                 265                 270         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro 
        275                 280                 285             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    290                 295                 300                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
305                 310                 315                 320 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                325                 330                 335     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            340                 345                 350         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        355                 360                 365             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    370                 375                 380                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
385                 390                 395                 400 


Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp 
                405                 410                 415     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            420                 425                 430         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    450                 455                 460                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
465                 470                 475                 480 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490                 495     


Lys 
    


<210>  3514
<211>  243
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Hole Fc

<400>  3514

His Met Ser Ser Val Ser Ala Gln Ala Ala Ala Glu Pro Lys Ser Ser 
1               5                   10                  15      


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
            20                  25                  30          


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        35                  40                  45              


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    50                  55                  60                  


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
65                  70                  75                  80  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                85                  90                  95      


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            100                 105                 110         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        115                 120                 125             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    130                 135                 140                 


Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
145                 150                 155                 160 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                165                 170                 175     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            180                 185                 190         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        195                 200                 205             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    210                 215                 220                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
225                 230                 235                 240 


Pro Gly Lys 
            


<210>  3515
<211>  497
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303  - ICOSL 2264 - Fc

<400>  3515

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser 
    130                 135                 140                 


Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu 
145                 150                 155                 160 


Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val 
                165                 170                 175     


Thr Tyr His Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg 
            180                 185                 190         


Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp 
        195                 200                 205             


Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe 
    210                 215                 220                 


His Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser 
225                 230                 235                 240 


Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys 
            260                 265                 270         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro 
        275                 280                 285             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    290                 295                 300                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
305                 310                 315                 320 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                325                 330                 335     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            340                 345                 350         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        355                 360                 365             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    370                 375                 380                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
385                 390                 395                 400 


Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp 
                405                 410                 415     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            420                 425                 430         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    450                 455                 460                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
465                 470                 475                 480 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490                 495     


Lys 
    


<210>  3516
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - ICOSL 2266 - Fc

<400>  3516

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
    130                 135                 140                 


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
145                 150                 155                 160 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
                165                 170                 175     


Tyr His Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
            180                 185                 190         


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
        195                 200                 205             


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
    210                 215                 220                 


Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
225                 230                 235                 240 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
            260                 265                 270         


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490                 495 


<210>  3517
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - ICOSL 2264 - Fc

<400>  3517

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
    130                 135                 140                 


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
145                 150                 155                 160 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
                165                 170                 175     


Tyr His Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr 
            180                 185                 190         


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
        195                 200                 205             


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
    210                 215                 220                 


Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
225                 230                 235                 240 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
            260                 265                 270         


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490                 495 


<210>  3518
<211>  500
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - CTLA-4 3495 - Fc

<400>  3518

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser 
    130                 135                 140                 


Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys 
145                 150                 155                 160 


Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val 
                165                 170                 175     


Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe 
            180                 185                 190         


Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn 
        195                 200                 205             


Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys 
    210                 215                 220                 


Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn 
225                 230                 235                 240 


Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp 
                245                 250                 255     


Gln Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys 
            260                 265                 270         


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
        275                 280                 285             


Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly 
            500 


<210>  3519
<211>  487
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L2 1417 - CTLA-4 3495 - Fc

<400>  3519

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val 
        115                 120                 125             


Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser 
    130                 135                 140                 


Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp 
145                 150                 155                 160 


Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu 
                165                 170                 175     


Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn 
            180                 185                 190         


Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu 
        195                 200                 205             


Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly 
    210                 215                 220                 


Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro 
225                 230                 235                 240 


Asp Ser Asp Gln Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            260                 265                 270         


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        275                 280                 285             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
305                 310                 315                 320 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                325                 330                 335     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            340                 345                 350         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    370                 375                 380                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
385                 390                 395                 400 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                405                 410                 415     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            420                 425                 430         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        435                 440                 445             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    450                 455                 460                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
465                 470                 475                 480 


Ser Leu Ser Leu Ser Pro Gly 
                485         


<210>  3520
<211>  500
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CTLA-4 2655 - PD-L1 303 - Fc

<400>  3520

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr 
    130                 135                 140                 


Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met 
145                 150                 155                 160 


Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala 
                165                 170                 175     


Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val 
            180                 185                 190         


His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg 
        195                 200                 205             


Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln 
    210                 215                 220                 


Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile 
225                 230                 235                 240 


Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn 
                245                 250                 255     


Ala Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys 
            260                 265                 270         


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
        275                 280                 285             


Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly 
            500 


<210>  3521
<211>  500
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - CTLA-4 2655 - Fc

<400>  3521

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser 
    130                 135                 140                 


Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys 
145                 150                 155                 160 


Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val 
                165                 170                 175     


Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe 
            180                 185                 190         


Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn 
        195                 200                 205             


Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys 
    210                 215                 220                 


Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn 
225                 230                 235                 240 


Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
                245                 250                 255     


Gln Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys 
            260                 265                 270         


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
        275                 280                 285             


Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly 
            500 


<210>  3522
<211>  499
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CTLA-4 3037 - PD-L1 303 -Fc

<400>  3522

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val 
    130                 135                 140                 


Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr 
145                 150                 155                 160 


Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu 
                165                 170                 175     


Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His 
            180                 185                 190         


Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala 
        195                 200                 205             


Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile 
    210                 215                 220                 


Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser 
225                 230                 235                 240 


Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
        275                 280                 285             


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  3523
<211>  499
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - CTLA-4 3037 - Fc

<400>  3523

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser 
    130                 135                 140                 


Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys 
145                 150                 155                 160 


Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val 
                165                 170                 175     


Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe 
            180                 185                 190         


Pro Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn 
        195                 200                 205             


Leu Thr Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys 
    210                 215                 220                 


Lys Val Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn 
225                 230                 235                 240 


Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
        275                 280                 285             


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  3524
<211>  497
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - Fc - CTLA-4 3037

<400>  3524

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys 
        115                 120                 125             


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
    130                 135                 140                 


Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        195                 200                 205             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
    370                 375                 380                 


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp 
385                 390                 395                 400 


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
                405                 410                 415     


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr 
            420                 425                 430         


Phe Pro Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
        435                 440                 445             


Asn Leu Thr Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
    450                 455                 460                 


Cys Lys Val Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly 
465                 470                 475                 480 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
                485                 490                 495     


Asp 
    


<210>  3525
<211>  129
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303

<400>  3525

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His 
        115                 120                 125             


His 
    


<210>  3526
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L2 1417

<400>  3526

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Gly Ser Asp Tyr Lys Asp Asp Asp Lys Gly 
            100                 105                 110         


Ser His His His His His His 
        115                 


<210>  3527
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ICOSL 2266

<400>  3527

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Asp Tyr Lys Asp Asp Asp 
        115                 120                 125             


Asp Lys His His His His His His 
    130                 135     


<210>  3528
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ICOSL 2264

<400>  3528

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Asp Tyr Lys Asp Asp Asp 
        115                 120                 125             


Asp Lys His His His His His His 
    130                 135     


<210>  3529
<211>  364
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CTLA-4 3037 - Fc

<400>  3529

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360                 


<210>  3530
<211>  364
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CTLA-4 36 - Fc

<400>  3530

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360                 


<210>  3531
<211>  356
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303  - Fc

<400>  3531

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys 
        115                 120                 125             


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
    130                 135                 140                 


Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        195                 200                 205             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly 
        355     


<210>  3532
<211>  451
<212>  PRT
<213>  Artificial sequence

<220>
<223>  huPDL2-Fc

<400>  3532

Ala Ile Leu Ala Leu Leu Leu Ala Val Leu Gln Gly Val Ser Ala Leu 
1               5                   10                  15      


Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser 
            20                  25                  30          


Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu 
        35                  40                  45              


Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro 
    50                  55                  60                  


His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys 
65                  70                  75                  80  


Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr 
                85                  90                  95      


Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr 
            100                 105                 110         


Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu Lys 
        115                 120                 125             


Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly Tyr 
    130                 135                 140                 


Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn Thr 
145                 150                 155                 160 


Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val Leu 
                165                 170                 175     


Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp Asn 
            180                 185                 190         


Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser Gln 
        195                 200                 205             


Met Glu Pro Arg Thr His Pro Thr Ala Ala Ala Glu Pro Lys Ser Ser 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
    290                 295                 300                 


Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  3533
<211>  243
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Stuffer_AAA_ Knob Fc

<400>  3533

His Met Ser Ser Val Ser Ala Gln Ala Ala Ala Glu Pro Lys Ser Ser 
1               5                   10                  15      


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
            20                  25                  30          


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        35                  40                  45              


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    50                  55                  60                  


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
65                  70                  75                  80  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                85                  90                  95      


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            100                 105                 110         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        115                 120                 125             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    130                 135                 140                 


Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
145                 150                 155                 160 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                165                 170                 175     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            180                 185                 190         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        195                 200                 205             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    210                 215                 220                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
225                 230                 235                 240 


Pro Gly Lys 
            


<210>  3534
<211>  367
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303  - Fc

<400>  3534

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
    130                 135                 140                 


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
145                 150                 155                 160 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                165                 170                 175     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            180                 185                 190         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        195                 200                 205             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    210                 215                 220                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
225                 230                 235                 240 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                245                 250                 255     


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu 
            260                 265                 270         


Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
        275                 280                 285             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    290                 295                 300                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
305                 310                 315                 320 


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                325                 330                 335     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Lys Ser Leu Ser Leu Ser Pro Gly His His His His His His 
        355                 360                 365         


<210>  3535
<211>  266
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303  - ICOSL 2244

<400>  3535

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
    130                 135                 140                 


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
145                 150                 155                 160 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
                165                 170                 175     


Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
            180                 185                 190         


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
        195                 200                 205             


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
    210                 215                 220                 


Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
225                 230                 235                 240 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Asp Tyr Lys Asp 
                245                 250                 255     


Asp Asp Asp Lys His His His His His His 
            260                 265     


<210>  3536
<211>  1476
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L2 31 - Fc

<400>  3536
atggggtcag ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctgat       60

actcaggaga aggaagtcag agcgatggta ggcagcgacg tggagctcag ctgcgcttgc      120

cctgaaggaa gccgttttga tttaaatgat gtttacgtat attggcaaac cagtgagtcg      180

aaaaccgtgg tgacctacca catcccacag cacagctcct tggaaaacgt ggacagccgc      240

taccggaacc gagccctgat gtcaccggcc ggcatgctgc ggggcgactt ctccctgcgc      300

ttgttcaacg tcacccccca ggacgagcag aagtttcact gcctggtgtt gagccgatcc      360

ctgggattcc aggaggtttt gagcgttgag gttacactgc atgtggcagc aaacttcagc      420

gtgcccgtcg tcagcgcccc ccacagcccc tcccaggatg agctcacctt cacgtgtaca      480

tccataaacg gctaccccag gcccaacgtg tactggatca ataagacgga caacagcctg      540

ctggaccagg ctctgcagaa tgacaccgtc ttcttgaaca tgcggggctt gtatgacgtg      600

gtcagcgtgc tgaggatcgc acggaccccc agcgtgaaca ttggctgctg catagagaac      660

gtgcttctgc agcagaacct gactgtcggc agccagacag gaaatgacat cggagagaga      720

gacaagatca cagagaatcc agtcagtacc ggcgagaaaa acgcggccac ggcggccgca      780

gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      840

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      900

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      960

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgtg cgaggagcag     1020

tacgggagca cgtaccgttg cgtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1080

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1140

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1200

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1260

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1320

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1380

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1440

tacacgcaga agagcctctc cctgtctccg ggtaag                               1476


<210>  3537
<211>  473
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L2 31 - Fc

<400>  3537

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr Ala Ala 
225                 230                 235                 240 


Ala Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu 
305                 310                 315                 320 


Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  3538
<211>  231
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fc

<400>  3538

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  3539
<211>  1125
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  - Fc

<400>  3539
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctttt       60

accgtaacgg tccctaagga tttgtacgtg gttgagtacg ggagcaatat gacgattgaa      120

tgcaagttcc ccgtagagaa gcagctcgat ttggccgctt tgatagtgta ctgggaaatg      180

gaaggaaaag acatcattca attcgtccac ggtgaagagg atcaaaaagc gcaacatagc      240

tcctatagac aacgcgcacg cttgcttaaa gaccagctga gtcttggtaa cgcggcgctg      300

cagattaccg acgtaaaact tcaagacgcg ggagtttatc gctgcatgat ttcctacggg      360

ggtggcgcag actataaaag gatcactgta aaggtaaacg ccggatccgg agggtctggg      420

ggaggcggtt ctgagcccaa atcttctgac aaaactcaca catgcccccc ttgtccagcg      480

cctgaactcc tgggtggacc ctctgtcttc cttttccccc ctaagccgaa agataccctg      540

atgatctccc gcactcccga agtcacatgt gttgttgtcg acgtatctca tgaagatcct      600

gaggtgaaat tcaactggta tgtagacggg gtcgaagttc ataatgctaa gactaagcca      660

cgagaagagc aatacaactc aacgtatcgg gtggtgagcg ttctgacggt tctgcaccaa      720

gattggctta atggaaaaga gtataagtgc aaggtgtcca acaaggctct tccggcaccc      780

atcgaaaaga cgatttccaa agcgaaaggc caacctaggg aaccgcaagt ttacactttg      840

cccccgtcaa gagacgaact taccaagaat caagtttccc tgacgtgcct tgtgaagggc      900

ttctacccta gcgatatagc agttgagtgg gaatctaacg gccagcccga aaataattat      960

aagactactc cgcccgtgct ggacagtgat ggttcatttt tcctgtattc aaaactcact     1020

gtggacaaat ctagatggca gcagggtaat gtgttctctt gttcagttat gcacgaggca     1080

ttgcacaatc actatacgca aaaaagtttg tctctctctc cgggg                     1125


<210>  3540
<211>  356
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303  - Fc

<400>  3540

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys 
        115                 120                 125             


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    130                 135                 140                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        195                 200                 205             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly 
        355     


<210>  3541
<211>  1558
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  - PD-L1 303  - Fc

<400>  3541
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctttt       60

actgttacgg tacccaaaga cctgtacgta gtggagtacg ggtccaatat gaccatagaa      120

tgcaaattcc ccgtcgagaa gcaattggat ctcgccgctc tgatcgtcta ctgggagatg      180

gagggcaaag atatcattca attcgtacac ggggaagaag atcagaaagc tcaacacagc      240

tcttacaggc aacgggcgag actgctcaag gaccaattga gtcttggaaa cgctgcactt      300

cagatcaccg acgtgaagtt gcaggatgca ggcgtgtatc ggtgcatgat aagctatgga      360

ggaggggcag attataaaag gattacggtg aaggtaaacg caggtggcgg aggttctggc      420

ggaggtggaa gtggcggagg tggctctttc acagtaacgg tccctaaaga tctctatgtc      480

gtggaatacg ggagcaacat gacaattgag tgcaagtttc cagtagaaaa gcaacttgat      540

ctggccgcgt tgatagtcta ctgggagatg gaaggtaagg acatcattca gtttgtacat      600

ggagaggaag accaaaaggc tcagcatagt tcctatcggc agagggcgag attgcttaaa      660

gaccagctct ccttgggaaa tgcagctctc cagattacgg atgtgaaatt gcaagatgct      720

ggcgtataca gatgtatgat tagctatgga ggaggtgcgg actataagag aatcacggtc      780

aaagttaatg ccgggtctgg gggaggcggt tctgagccca aatcttctga caaaactcac      840

acatgccccc cttgtccagc gcctgaactc ctgggtggac cctctgtctt ccttttcccc      900

cctaagccga aagataccct gatgatctcc cgcactcccg aagtcacatg tgttgttgtc      960

gacgtatctc atgaagatcc tgaggtgaaa ttcaactggt atgtagacgg ggtcgaagtt     1020

cataatgcta agactaagcc acgagaagag caatacaact caacgtatcg ggtggtgagc     1080

gttctgacgg ttctgcacca agattggctt aatggaaaag agtataagtg caaggtgtcc     1140

aacaaggctc ttccggcacc catcgaaaag acgatttcca aagcgaaagg ccaacctagg     1200

gaaccgcaag tttacacttt gcccccgtca agagacgaac ttaccaagaa tcaagtttcc     1260

ctgacgtgcc ttgtgaaggg cttctaccct agcgatatag cagttgagtg ggaatctaac     1320

ggccagcccg aaaataatta taagactact ccgcccgtgc tggacagtga tggttcattt     1380

ttcctgtatt caaaactcac tgtggacaaa tctagatggc agcagggtaa tgtgttctct     1440

tgttcagtta tgcacgaggc attgcacaat cactatacgc aaaaaagttt gtctctctct     1500

ccggggtaag atatctcgac aatcaacctc tggattacaa aatttgtgaa agattgac       1558


<210>  3542
<211>  483
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303  - PD-L1 303  - Fc

<400>  3542

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
    130                 135                 140                 


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
145                 150                 155                 160 


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile 
                165                 170                 175     


Ile Gln Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser 
            180                 185                 190         


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
        195                 200                 205             


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
    210                 215                 220                 


Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr 
225                 230                 235                 240 


Val Lys Val Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
                245                 250                 255     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly 
            


<210>  3543
<211>  798
<212>  DNA
<213>  artificial sequence

<220>
<223>  PD-L1 303  ICOSL 2264

<400>  3543
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggatc cggagggtct      360

gggggaggcg gttctggggg tggaggctca gatactcagg agaaggaagt cagagcgatg      420

gtaggcagcg acgtggagct cagctgcgct tgccctgaag gaagccgttt tgatttaaat      480

gatgtttacg tatattggca aaccagtgag tcgaaaaccg tggtgaccta ccacatccca      540

cagcacagct ccttggaata tgtggacagc cgctaccgga accgagccct gatgtcaccg      600

gccggcatgc tgcggggcga cttctccctg cgcttgttca acgtcacccc ccaggacgag      660

cagaagtttc actgcctggt gttgagcaga tccctgggat tccaggaggt tttgagcgtt      720

gaggttacac tgcatgtggc agcaaacttc agcgtggatt acaaggatga cgacgataag      780

caccatcatc accatcac                                                    798


<210>  3544
<211>  798
<212>  DNA
<213>  artificial sequence

<220>
<223>  PD-L1 303  ICOSL 2266

<400>  3544
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggatc cggagggtct      360

gggggaggcg gttctggggg tggaggctca gatactcagg agaaggaagt cagagcgatg      420

gtaggcagcg acgtggagct cagctgcgct tgccctgaag gaagccgttt tgatttaaat      480

gatgtttacg tatattggca aaccagtgag tcgaaaaccg tggtgaccta ccacatccca      540

cagcacagct ccttggaaaa cgtggacagc cgctaccgga accgagccct gatgtcaccg      600

gccggcatgc tgcggggcga cttctccctg cgcttgttca acgtcacccc ccaggacgag      660

cagaagtttc actgcctggt gttgagcaga tccctgggat tccaggaggt tttgagcgtt      720

gaggttacac tgcatgtggc agcaaacttc agcgtggatt acaaggatga cgacgataag      780

caccatcatc accatcac                                                    798


<210>  3545
<211>  759
<212>  DNA
<213>  artificial sequence

<220>
<223>  PD-L2 1417  ICOSL 2266:

<400>  3545
ttattcacag tgactgttcc gaaagagttg tatataatcg agcaagggag taatgttacc       60

ctggaatgca attttgacac cgggtcacac gtcaacctcg gagcgattac tgcttctttg      120

caaaaagttg aaaacgacgc gtccccccat agggaaaggg cgacccttct ggaggagcag      180

ttgccccttg gcagggcact ctttcacatt ccccaggtgc aagtcaggga cgaggggcaa      240

taccgctgca tcataattta cggggacgcg tgggactaca agtacttgac tctcaaagtt      300

aaagctggat ccggagggtc tgggggaggc ggttctgggg gtggaggctc agatactcag      360

gagaaggaag tcagagcgat ggtaggcagc gacgtggagc tcagctgcgc ttgccctgaa      420

ggaagccgtt ttgatttaaa tgatgtttac gtatattggc aaaccagtga gtcgaaaacc      480

gtggtgacct accacatccc acagcacagc tccttggaaa acgtggacag ccgctaccgg      540

aaccgagccc tgatgtcacc ggccggcatg ctgcggggcg acttctccct gcgcttgttc      600

aacgtcaccc cccaggacga gcagaagttt cactgcctgg tgttgagcag atccctggga      660

ttccaggagg ttttgagcgt tgaggttaca ctgcatgtgg cagcaaactt cagcgtggat      720

tacaaggatg acgacgataa gcaccatcat caccatcac                             759


<210>  3546
<211>  759
<212>  DNA
<213>  artificial sequence

<220>
<223>  PD-L2 1417  ICOSL 2264:

<400>  3546
ttattcacag tgactgttcc gaaagagttg tatataatcg agcaagggag taatgttacc       60

ctggaatgca attttgacac cgggtcacac gtcaacctcg gagcgattac tgcttctttg      120

caaaaagttg aaaacgacgc gtccccccat agggaaaggg cgacccttct ggaggagcag      180

ttgccccttg gcagggcact ctttcacatt ccccaggtgc aagtcaggga cgaggggcaa      240

taccgctgca tcataattta cggggacgcg tgggactaca agtacttgac tctcaaagtt      300

aaagctggat ccggagggtc tgggggaggc ggttctgggg gtggaggctc agatactcag      360

gagaaggaag tcagagcgat ggtaggcagc gacgtggagc tcagctgcgc ttgccctgaa      420

ggaagccgtt ttgatttaaa tgatgtttac gtatattggc aaaccagtga gtcgaaaacc      480

gtggtgacct accacatccc acagcacagc tccttggaat atgtggacag ccgctaccgg      540

aaccgagccc tgatgtcacc ggccggcatg ctgcggggcg acttctccct gcgcttgttc      600

aacgtcaccc cccaggacga gcagaagttt cactgcctgg tgttgagcag atccctggga      660

ttccaggagg ttttgagcgt tgaggttaca ctgcatgtgg cagcaaactt cagcgtggat      720

tacaaggatg acgacgataa gcaccatcat caccatcac                             759


<210>  3547
<211>  1599
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  PD-L1 303  ICOSL 2264  ICOSL 2264

<400>  3547
tttacagtaa cagtacccaa agacctgtat gtcgtcgaat acgggtcaaa catgactatt       60

gagtgtaaat tcccggtaga aaagcaactt gatctggcag ccctgattgt atattgggaa      120

atggagggca aggatataat ccaatttgtt cacggcgagg aggatcagaa agcacagcac      180

tcttcatata ggcagagggc acgcctgctg aaagatcaac ttagtctggg taatgcagcc      240

ttgcaaatta cagatgttaa gttacaggat gcgggtgtgt accggtgtat gattagttac      300

ggcggaggag cagattataa acggatcacc gttaaggtga acgccggagg tggtggatca      360

ggtggaggag gttccggagg aggtggatct tttaccgtaa cggtccctaa ggatttgtac      420

gtggttgagt acgggagcaa tatgacgatt gaatgcaagt tccccgtaga gaagcagctc      480

gatttggccg ctttgatagt gtactgggaa atggaaggaa aagacatcat tcaattcgtc      540

cacggtgaag aggatcaaaa agcgcaacat agctcctata gacaacgcgc acgcttgctt      600

aaagaccagc tgagtcttgg taacgcggcg ctgcagatta ccgacgtaaa acttcaagac      660

gcgggagttt atcgctgcat gatttcctac gggggtggcg cagactataa aaggatcact      720

gtaaaggtaa acgccggtgg aggtggctct ggaggtggtg gaagcggtgg cggtggtagc      780

gatactcagg agaaggaagt cagagcgatg gtaggcagcg acgtggagct cagctgcgct      840

tgccctgaag gaagccgttt tgatttaaat gatgtttacg tatattggca aaccagtgag      900

tcgaaaaccg tggtgaccta ccacatccca cagcacagct ccttggaata tgtggacagc      960

cgctaccgga accgagccct gatgtcaccg gccggcatgc tgcggggcga cttctccctg     1020

cgcttgttca acgtcacccc ccaggacgag cagaagtttc actgcctggt gttgagcaga     1080

tccctgggat tccaggaggt tttgagcgtt gaggttacac tgcatgtggc agcaaacttc     1140

agcgtgggat ccggagggtc tgggggaggc ggttctgggg gtggaggctc agatactcag     1200

gaaaaggaag tgagagcaat ggttgggtca gatgtggaat tgagctgtgc atgccccgaa     1260

ggaagtagat tcgatctcaa tgatgtctat gtgtactggc aaaccagcga gagcaagact     1320

gtggtaacct atcacattcc gcaacacagt tcacttgaat atgtggatag ccggtaccga     1380

aatcgggctc ttatgtctcc ggcagggatg cttaggggtg acttttcctt gagacttttc     1440

aacgtcactc ctcaggacga gcagaaattc cattgtcttg tcctgtctcg gtccttgggg     1500

tttcaggaag tgctgtctgt agaggtgacg ctgcacgtcg ctgctaactt tagcgtggat     1560

tacaaggatg acgacgataa gcaccatcat caccatcac                            1599


<210>  3548
<211>  1188
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  ICOSL 2264   PD-L1 303

<400>  3548
tttacagtaa cagtacccaa agacctgtat gtcgtcgaat acgggtcaaa catgactatt       60

gagtgtaaat tcccggtaga aaagcaactt gatctggcag ccctgattgt atattgggaa      120

atggagggca aggatataat ccaatttgtt cacggcgagg aggatcagaa agcacagcac      180

tcttcatata ggcagagggc acgcctgctg aaagatcaac ttagtctggg taatgcagcc      240

ttgcaaatta cagatgttaa gttgcaggat gcgggtgtgt accggtgtat gattagttac      300

ggcggaggag cagattataa acggatcacc gttaaggtga acgccggagg tggtggatca      360

ggtggaggag gttccggagg aggtggatct gatactcagg agaaggaagt cagagcgatg      420

gtaggcagcg acgtggagct cagctgcgct tgccctgaag gaagccgttt tgatttaaat      480

gatgtttacg tatattggca aaccagtgag tcgaaaaccg tggtgaccta ccacatccca      540

cagcacagct ccttggaata tgtggacagc cgctaccgga accgagccct gatgtcaccg      600

gccggcatgc tgcggggcga cttctccctg cgcttgttca acgtcacccc ccaggacgag      660

cagaagtttc actgcctggt gttgagcaga tccctgggat tccaggaggt tttgagcgtt      720

gaggttacac tgcatgtggc agcaaacttc agcgtgggtg gaggtggctc tggaggtggt      780

ggaagcggtg gcggtggtag ctttaccgta acggtcccta aggatttgta cgtggttgag      840

tacgggagca atatgacgat tgaatgcaag ttccccgtag agaagcagct cgatttggcc      900

gctttgatag tgtactggga aatggaagga aaagacatca ttcaattcgt ccacggtgaa      960

gaggatcaaa aagcgcaaca tagctcctat agacaacgcg cacgcttgct taaagaccag     1020

ctgagtcttg gtaacgcggc gctgcagatt accgacgtaa aacttcaaga cgcgggagtt     1080

tatcgctgca tgatttccta cgggggtggc gcagactata aaaggatcac tgtaaaggta     1140

aacgccgatt acaaggatga cgacgataag caccatcatc accatcac                  1188


<210>  3549
<211>  1599
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303   ICOSL 2264  ICOSL 2264   PD-L1 303

<400>  3549
tttacagtaa cagtacccaa agacctgtat gtcgtcgaat acgggtcaaa catgactatt       60

gagtgtaaat tcccggtaga aaagcaactt gatctggcag ccctgattgt atattgggaa      120

atggagggca aggatataat ccaatttgtt cacggcgagg aggatcagaa agcacagcac      180

tcttcatata ggcagagggc acgcctgctg aaagatcaac ttagtctggg taatgcagcc      240

ttgcaaatta cagatgttaa gttgcaggat gcgggtgtgt accggtgtat gattagttac      300

ggcggaggag cagattataa acggatcacc gttaaggtga acgccggagg tggtggatca      360

ggtggaggag gttccggagg aggtggatct gatactcagg agaaggaagt cagagcgatg      420

gtaggcagcg acgtggagct cagctgcgct tgccctgaag gaagccgttt tgatttaaat      480

gatgtttacg tatattggca aaccagtgag tcgaaaaccg tggtgaccta ccacatccca      540

cagcacagct ccttggaata tgtggacagc cgctaccgga accgagccct gatgtcaccg      600

gccggcatgc tgcggggcga cttctccctg cgcttgttca acgtcacccc ccaggacgag      660

cagaagtttc actgcctggt gttgagcaga tccctgggat tccaggaggt tttgagcgtt      720

gaggttacac tgcatgtggc agcaaacttc agcgtgggtg gaggtggctc tggaggtggt      780

ggaagcggtg gcggtggtag cgatactcag gaaaaggaag tgagagcaat ggttgggtca      840

gatgtggaat tgagctgtgc atgccccgaa ggaagtagat tcgatctcaa tgatgtctat      900

gtgtactggc aaaccagcga gagcaagact gtggtaacct atcacattcc gcaacacagt      960

tcacttgaat atgtggatag ccggtaccga aatcgggctc ttatgtctcc ggcagggatg     1020

cttaggggtg acttttcctt gagacttttc aacgtcactc ctcaggacga gcagaaattc     1080

cattgtcttg tcctgtctcg gtccttgggg tttcaggaag tgctgtctgt agaggtgacg     1140

ctgcacgtcg ctgctaactt tagcgtggga tccggagggt ctgggggagg cggttctggg     1200

ggtggaggct catttaccgt aacggtccct aaggatttgt acgtggttga gtacgggagc     1260

aatatgacga ttgaatgcaa gttccccgta gagaagcagc tcgatttggc cgctttgata     1320

gtgtactggg aaatggaagg aaaagacatc attcaattcg tccacggtga agaggatcaa     1380

aaagcgcaac atagctccta tagacaacgc gcacgcttgc ttaaagacca gctgagtctt     1440

ggtaacgcgg cgctgcagat taccgacgta aaacttcaag acgcgggagt ttatcgctgc     1500

atgatttcct acgggggtgg cgcagactat aaaaggatca ctgtaaaggt aaacgccgat     1560

tacaaggatg acgacgataa gcaccatcat caccatcac                            1599


<210>  3550
<211>  567
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  COMP

<400>  3550
tttacagtaa cagtacccaa agacctgtat gtcgtcgaat acgggtcaaa catgactatt       60

gagtgtaaat tcccggtaga aaagcaactt gatctggcag ccctgattgt atattgggaa      120

atggagggca aggatataat ccaatttgtt cacggcgagg aggatcagaa agcacagcac      180

tcttcatata ggcagagggc acgcctgctg aaagatcaac ttagtctggg taatgcagcc      240

ttgcaaatta cagatgttaa gttgcaggat gcgggtgtgt accggtgtat gattagttac      300

ggcggaggag cagattataa acggatcacc gttaaggtga acgccggagg tggtggatca      360

ggtggaggag gttccggagg aggtggatct gatttgggtc cacaaatgct gagggagttg      420

caggagacaa atgccgcttt gcaagacgtt agagagcttc tgagacaaca agtgcgcgag      480

atcacgttct tgaagaacac agttatggaa tgcgacgctt gcggcgatta caaggatgac      540

gacgataagc accatcatca ccatcac                                          567


<210>  3551
<211>  978
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  ICOSL 2264 COMP

<400>  3551
tttacagtaa cagtacccaa agacctgtat gtcgtcgaat acgggtcaaa catgactatt       60

gagtgtaaat tcccggtaga aaagcaactt gatctggcag ccctgattgt atattgggaa      120

atggagggca aggatataat ccaatttgtt cacggcgagg aggatcagaa agcacagcac      180

tcttcatata ggcagagggc acgcctgctg aaagatcaac ttagtctggg taatgcagcc      240

ttgcaaatta cagatgttaa gttgcaggat gcgggtgtgt accggtgtat gattagttac      300

ggcggaggag cagattataa acggatcacc gttaaggtga acgccggagg tggtggatca      360

ggtggaggag gttccggagg aggtggatct gatactcagg agaaggaagt cagagcgatg      420

gtaggcagcg acgtggagct cagctgcgct tgccctgaag gaagccgttt tgatttaaat      480

gatgtttacg tatattggca aaccagtgag tcgaaaaccg tggtgaccta ccacatccca      540

cagcacagct ccttggaata tgtggacagc cgctaccgga accgagccct gatgtcaccg      600

gccggcatgc tgcggggcga cttctccctg cgcttgttca acgtcacccc ccaggacgag      660

cagaagtttc actgcctggt gttgagcaga tccctgggat tccaggaggt tttgagcgtt      720

gaggttacac tgcatgtggc agcaaacttc agcgtgggtg gaggtggctc tggaggtggt      780

ggaagcggtg gcggtggtag cgatttgggt ccacaaatgc tgagggagtt gcaggagaca      840

aatgccgctt tgcaagacgt tagagagctt ctgagacaac aagtgcgcga gatcacgttc      900

ttgaagaaca cagttatgga atgcgacgct tgcggcgatt acaaggatga cgacgataag      960

caccatcatc accatcac                                                    978


<210>  3552
<211>  531
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  VASP

<400>  3552
tttactgtta cggtacccaa agacctgtac gtagtggagt acgggtccaa tatgaccata       60

gaatgcaaat tccccgtcga gaagcaattg gatctcgccg ctctgatcgt ctactgggag      120

atggagggca aagatatcat tcaattcgta cacggggaag aagatcagaa agctcaacac      180

agctcttaca ggcaacgggc gagactgctc aaggaccaat tgagtcttgg aaacgctgca      240

cttcagatca ccgacgtgaa gttgcaggat gcaggcgtgt atcggtgcat gataagctat      300

ggaggagggg cagattataa aaggattacg gtgaaggtaa acgcaggtgg cggaggttct      360

ggcggaggtg gaagtggcgg aggtggctct gatctccaga gggtcaaaca agagctgctt      420

gaagaggtga aaaaggagct tcagaaggtt aaagaagaaa ttatagaggc attcgttcaa      480

gaattgagag actataaaga tgacgacgac aaacaccatc atcaccatca c               531


<210>  3553
<211>  942
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  ICOSL 2264  VASP

<400>  3553
tttactgtta cggtacccaa agacctgtac gtagtggagt acgggtccaa tatgaccata       60

gaatgcaaat tccccgtcga gaagcaattg gatctcgccg ctctgatcgt ctactgggag      120

atggagggca aagatatcat tcaattcgta cacggggaag aagatcagaa agctcaacac      180

agctcttaca ggcaacgggc gagactgctc aaggaccaat tgagtcttgg aaacgctgca      240

cttcagatca ccgacgtgaa gttgcaggat gcaggcgtgt atcggtgcat gataagctat      300

ggaggagggg cagattataa aaggattacg gtgaaggtaa acgcaggtgg cggaggttct      360

ggcggaggtg gaagtggcgg aggtggctct gatactcagg agaaggaagt cagagcgatg      420

gtaggcagcg acgtggagct cagctgcgct tgccctgaag gaagccgttt tgatttaaat      480

gatgtttacg tatattggca aaccagtgag tcgaaaaccg tggtgaccta ccacatccca      540

cagcacagct ccttggaata tgtggacagc cgctaccgga accgagccct gatgtcaccg      600

gccggcatgc tgcggggcga cttctccctg cgcttgttca acgtcacccc ccaggacgag      660

cagaagtttc actgcctggt gttgagcaga tccctgggat tccaggaggt tttgagcgtt      720

gaggttacac tgcatgtggc agcaaacttc agcgtgggtg gtggtgggag tgggggcggg      780

ggttcaggag gcggcggctc tgatctccag agggtcaaac aagagctgct tgaagaggtg      840

aaaaaggagc ttcagaaggt taaagaagaa attatagagg cattcgttca agaattgaga      900

gactataaag atgacgacga caaacaccat catcaccatc ac                         942


<210>  3554
<211>  525
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ZZ12.6  PD-L1 303

<400>  3554
gactataaag atgacgacga caaacaccat catcaccatc acggtggcgg aggttcttcc       60

gacgtccagg cgatctcctc caccatccag gaccttcagg accaggtcga ctccctggcg      120

gaggtggtgc tgcagaatcg ccgcggcctt gaccttctta cgagaagcgg cggtggatca      180

tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt      240

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      300

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      360

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      420

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      480

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgcc                      525


<210>  3555
<211>  552
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  ZZ12.6

<400>  3555
tttactgtta cggtacccaa agacctgtac gtagtggagt acgggtccaa tatgaccata       60

gaatgcaaat tccccgtcga gaagcaattg gatctcgccg ctctgatcgt ctactgggag      120

atggagggca aagatatcat tcaattcgta cacggggaag aagatcagaa agctcaacac      180

agctcttaca ggcaacgggc gagactgctc aaggaccaat tgagtcttgg aaacgctgca      240

cttcagatca ccgacgtgaa gttgcaggat gcaggcgtgt atcggtgcat gataagctat      300

ggaggagggg cagattataa aaggattacg gtgaaggtaa acgcaggtgg cggaggttct      360

ggcggaggtg gaagtggcgg aggtggctct gacgtccagg cgatctcctc caccatccag      420

gaccttcagg accaggtcga ctccctggcg gaggtggtgc tgcagaatcg ccgcggcctt      480

gaccttctta cgagaagcgg cggtggatca gactataaag atgacgacga caaacaccat      540

catcaccatc ac                                                          552


<210>  3556
<211>  1488
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303   ICOSL 2266  Fc

<400>  3556
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggatc cggagggtct      360

gggggaggcg gttctggggg tggaggctca gatactcagg agaaggaagt cagagcgatg      420

gtaggcagcg acgtggagct cagctgcgct tgccctgaag gaagccgttt tgatttaaat      480

gatgtttacg tatattggca aaccagtgag tcgaaaaccg tggtgaccta ccacatccca      540

cagcacagct ccttggaaaa cgtggacagc cgctaccgga accgagccct gatgtcaccg      600

gccggcatgc tgcggggcga cttctccctg cgcttgttca acgtcacccc ccaggacgag      660

cagaagtttc actgcctggt gttgagcaga tccctgggat tccaggaggt tttgagcgtt      720

gaggttacac tgcatgtggc agcaaacttc agcgtgggtg gaggagggtc aggatccggg      780

ggaggtggaa gcgagcccaa aagctccgac aagactcaca catgcccccc ttgtccagcg      840

cctgaagctg agggtgcgcc ctctgtcttc cttttccccc ctaagccgaa agataccctg      900

atgatctccc gcactcccga agtcacatgt gttgttgtcg acgtatctca tgaagatcct      960

gaggtgaaat tcaactggta tgtagacggg gtcgaagttc ataatgctaa gactaagcca     1020

cgagaagagc aatacaactc aacgtatcgg gtggtgagcg ttctgacggt tctgcaccaa     1080

gattggctta atggaaaaga gtataagtgc aaggtgtcca acaaggctct tccggcaccc     1140

atcgaaaaga cgatttccaa agcgaaaggc caacctaggg aaccgcaagt ttacactttg     1200

cccccgtgca gagaagaaat gaccaagaat caagtttccc tgtggtgcct tgtgaagggc     1260

ttctacccta gcgatatagc agttgagtgg gaatctaacg gccagcccga aaataattat     1320

aagactactc cgcccgtgct ggacagtgat ggttcatttt tcctgtattc aaaactcact     1380

gtggacaaat ctagatggca gcagggtaat gtgttctctt gttcagttat gcacgaggca     1440

ttgcacaatc actatacgca aaaaagtttg tctctctctc cggggaag                  1488


<210>  3557
<211>  729
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Hole Fc

<400>  3557
cacatgtctt cggtaagtgc acaggcggcc gcagagccca aaagctccga caagactcac       60

acatgccccc cttgtccagc gcctgaagct gagggtgcgc cctctgtctt ccttttcccc      120

cctaagccga aagataccct gatgatctcc cgcactcccg aagtcacatg tgttgttgtc      180

gacgtatctc atgaagatcc tgaggtgaaa ttcaactggt atgtagacgg ggtcgaagtt      240

cataatgcta agactaagcc acgagaagag caatacaact caacgtatcg ggtggtgagc      300

gttctgacgg ttctgcacca agattggctt aatggaaaag agtataagtg caaggtgtcc      360

aacaaggctc ttccggcacc catcgaaaag acgatttcca aagcgaaagg ccaacctagg      420

gaaccgcaag tttgcacttt gcccccgtca agagaagaaa tgaccaagaa tcaagtttcc      480

ctgtcttgcg cagtgaaggg cttctaccct agcgatatag cagttgagtg ggaatctaac      540

ggccagcccg aaaataatta taagactact ccgcccgtgc tggacagtga tggttcattt      600

ttcctggttt caaaactcac tgtggacaaa tctagatggc agcagggtaa tgtgttctct      660

tgttcagtta tgcacgaggc attgcacaat cactatacgc aaaaaagttt gtctctctct      720

ccggggaag                                                              729


<210>  3558
<211>  1488
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303   ICOSL 2264  Fc

<400>  3558
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggatc cggagggtct      360

gggggaggcg gttctggggg tggaggctca gatactcagg agaaggaagt cagagcgatg      420

gtaggcagcg acgtggagct cagctgcgct tgccctgaag gaagccgttt tgatttaaat      480

gatgtttacg tatattggca aaccagtgag tcgaaaaccg tggtgaccta ccacatccca      540

cagcacagct ccttggaata tgtggacagc cgctaccgga accgagccct gatgtcaccg      600

gccggcatgc tgcggggcga cttctccctg cgcttgttca acgtcacccc ccaggacgag      660

cagaagtttc actgcctggt gttgagcaga tccctgggat tccaggaggt tttgagcgtt      720

gaggttacac tgcatgtggc agcaaacttc agcgtgggtg gaggagggtc aggatccggg      780

ggaggtggaa gcgagcccaa aagctccgac aagactcaca catgcccccc ttgtccagcg      840

cctgaagctg agggtgcgcc ctctgtcttc cttttccccc ctaagccgaa agataccctg      900

atgatctccc gcactcccga agtcacatgt gttgttgtcg acgtatctca tgaagatcct      960

gaggtgaaat tcaactggta tgtagacggg gtcgaagttc ataatgctaa gactaagcca     1020

cgagaagagc aatacaactc aacgtatcgg gtggtgagcg ttctgacggt tctgcaccaa     1080

gattggctta atggaaaaga gtataagtgc aaggtgtcca acaaggctct tccggcaccc     1140

atcgaaaaga cgatttccaa agcgaaaggc caacctaggg aaccgcaagt ttacactttg     1200

cccccgtgca gagaagaaat gaccaagaat caagtttccc tgtggtgcct tgtgaagggc     1260

ttctacccta gcgatatagc agttgagtgg gaatctaacg gccagcccga aaataattat     1320

aagactactc cgcccgtgct ggacagtgat ggttcatttt tcctgtattc aaaactcact     1380

gtggacaaat ctagatggca gcagggtaat gtgttctctt gttcagttat gcacgaggca     1440

ttgcacaatc actatacgca aaaaagtttg tctctctctc cggggaag                  1488


<210>  3559
<211>  1485
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  ICOSL 2266  Fc

<400>  3559
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggatc cggagggtct      360

gggggaggcg gttctggggg tggaggctca gatactcagg agaaggaagt cagagcgatg      420

gtaggcagcg acgtggagct cagctgcgct tgccctgaag gaagccgttt tgatttaaat      480

gatgtttacg tatattggca aaccagtgag tcgaaaaccg tggtgaccta ccacatccca      540

cagcacagct ccttggaaaa cgtggacagc cgctaccgga accgagccct gatgtcaccg      600

gccggcatgc tgcggggcga cttctccctg cgcttgttca acgtcacccc ccaggacgag      660

cagaagtttc actgcctggt gttgagcaga tccctgggat tccaggaggt tttgagcgtt      720

gaggttacac tgcatgtggc agcaaacttc agcgtgggtg gaggtgggtc aggatccggt      780

ggaggagggt cagagcccaa aagctccgac aagactcaca catgcccccc ttgtccagcg      840

cctgaagctg agggtgcgcc ctctgtcttc cttttccccc ctaagccgaa agataccctg      900

atgatctccc gcactcccga agtcacatgt gttgttgtcg acgtatctca tgaagatcct      960

gaggtgaaat tcaactggta tgtagacggg gtcgaagttc ataatgctaa gactaagcca     1020

cgagaagagc aatacaactc aacgtatcgg gtggtgagcg ttctgacggt tctgcaccaa     1080

gattggctta atggaaaaga gtataagtgc aaggtgtcca acaaggctct tccggcaccc     1140

atcgaaaaga cgatttccaa agcgaaaggc caacctaggg aaccgcaagt ttacactttg     1200

cccccgtcaa gagacgaact taccaagaat caagtttccc tgacgtgcct tgtgaagggc     1260

ttctacccta gcgatatagc agttgagtgg gaatctaacg gccagcccga aaataattat     1320

aagactactc cgcccgtgct ggacagtgat ggttcatttt tcctgtattc aaaactcact     1380

gtggacaaat ctagatggca gcagggtaat gtgttctctt gttcagttat gcacgaggca     1440

ttgcacaatc actatacgca aaaaagtttg tctctctctc cgggg                     1485


<210>  3560
<211>  1485
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  ICOSL 2264 Fc

<400>  3560
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggatc cggagggtct      360

gggggaggcg gttctggggg tggaggctca gatactcagg agaaggaagt cagagcgatg      420

gtaggcagcg acgtggagct cagctgcgct tgccctgaag gaagccgttt tgatttaaat      480

gatgtttacg tatattggca aaccagtgag tcgaaaaccg tggtgaccta ccacatccca      540

cagcacagct ccttggaata tgtggacagc cgctaccgga accgagccct gatgtcaccg      600

gccggcatgc tgcggggcga cttctccctg cgcttgttca acgtcacccc ccaggacgag      660

cagaagtttc actgcctggt gttgagcaga tccctgggat tccaggaggt tttgagcgtt      720

gaggttacac tgcatgtggc agcaaacttc agcgtgggtg gaggtgggtc aggatccggt      780

ggaggagggt cagagcccaa aagctccgac aagactcaca catgcccccc ttgtccagcg      840

cctgaagctg agggtgcgcc ctctgtcttc cttttccccc ctaagccgaa agataccctg      900

atgatctccc gcactcccga agtcacatgt gttgttgtcg acgtatctca tgaagatcct      960

gaggtgaaat tcaactggta tgtagacggg gtcgaagttc ataatgctaa gactaagcca     1020

cgagaagagc aatacaactc aacgtatcgg gtggtgagcg ttctgacggt tctgcaccaa     1080

gattggctta atggaaaaga gtataagtgc aaggtgtcca acaaggctct tccggcaccc     1140

atcgaaaaga cgatttccaa agcgaaaggc caacctaggg aaccgcaagt ttacactttg     1200

cccccgtcaa gagacgaact taccaagaat caagtttccc tgacgtgcct tgtgaagggc     1260

ttctacccta gcgatatagc agttgagtgg gaatctaacg gccagcccga aaataattat     1320

aagactactc cgcccgtgct ggacagtgat ggttcatttt tcctgtattc aaaactcact     1380

gtggacaaat ctagatggca gcagggtaat gtgttctctt gttcagttat gcacgaggca     1440

ttgcacaatc actatacgca aaaaagtttg tctctctctc cgggg                     1485


<210>  3561
<211>  1500
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  CTLA-4 3495  Fc

<400>  3561
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggatc cggagggtct      360

gggggaggcg gttctggggg tggaggctca aaggcgatgc acgtagccca gcccgctgtt      420

gttctcgcaa gttctcgcgg catagcctcc ttcgtatgtg agtatgccag tccaggtaag      480

gcaacggagg tacgggtaac tgtactgcgg caggccgatt cccaggttac ggaggtttgt      540

gcggcaacct acatgatggg taacgagctt acatttctcg acgactcaat atgtactggg      600

acctcctcag gaaatcaggt caatctgacc atccaaggtc tgagggcgat ggatacgggt      660

ctttatattt gcaaggttga actcatgtat ccgcctccat actatctggg cattggaaat      720

ggaacacaaa tctatgttat tgacccggag ccgtctccag atagtgatca gggtggaggt      780

gggtcaggat ccggtggagg agggtcagag cccaaaagct ccgacaagac tcacacatgc      840

cccccttgtc cagcgcctga agctgagggt gcgccctctg tcttcctttt cccccctaag      900

ccgaaagata ccctgatgat ctcccgcact cccgaagtca catgtgttgt tgtcgacgta      960

tctcatgaag atcctgaggt gaaattcaac tggtatgtag acggggtcga agttcataat     1020

gctaagacta agccacgaga agagcaatac aactcaacgt atcgggtggt gagcgttctg     1080

acggttctgc accaagattg gcttaatgga aaagagtata agtgcaaggt gtccaacaag     1140

gctcttccgg cacccatcga aaagacgatt tccaaagcga aaggccaacc tagggaaccg     1200

caagtttaca ctttgccccc gtcaagagac gaacttacca agaatcaagt ttccctgacg     1260

tgccttgtga agggcttcta ccctagcgat atagcagttg agtgggaatc taacggccag     1320

cccgaaaata attataagac tactccgccc gtgctggaca gtgatggttc atttttcctg     1380

tattcaaaac tcactgtgga caaatctaga tggcagcagg gtaatgtgtt ctcttgttca     1440

gttatgcacg aggcattgca caatcactat acgcaaaaaa gtttgtctct ctctccgggg     1500


<210>  3562
<211>  1461
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L2 1417  CTLA-4 3495  Fc

<400>  3562
ttattcacag tgactgttcc taaggaactg tacataatag agcaaggcag caatgtgacc       60

ctggaatgca actttgacac tggaagtcat gtgaaccttg gagcaataac agccagtttg      120

caaaaggtgg agaatgatgc atccccacac cgtgaaagag ccactttgct ggaggagcag      180

ctgcccctag ggagggcctt gttccacata cctcaagtcc aagtgaggga cgaaggacag      240

taccgatgca taatcatcta tggggacgcc tgggactaca agtacttgac tctcaaagtt      300

aaagctggat ccggagggtc tgggggaggc ggttctgggg gtggaggctc aaaggcgatg      360

cacgtagccc agcccgctgt tgttctcgca agttctcgcg gcatagcctc cttcgtatgt      420

gagtatgcca gtccaggtaa ggcaacggag gtacgggtaa ctgtactgcg gcaggccgat      480

tcccaggtta cggaggtttg tgcggcaacc tacatgatgg gtaacgagct tacatttctc      540

gacgactcaa tatgtactgg gacctcctca ggaaatcagg tcaacctgac catccaaggt      600

ctgagggcga tggatacggg tctttatatt tgcaaggttg aactcatgta tccgcctcca      660

tactatctgg gcattggaaa tggaacacaa atctatgtta ttgacccgga gccgtctcca      720

gatagtgatc agggtggagg tgggtcagga tccggtggag gagggtcaga gcccaaaagc      780

tccgacaaga ctcacacatg ccccccttgt ccagcgcctg aagctgaggg tgcgccctct      840

gtcttccttt tcccccctaa gccgaaagat accctgatga tctcccgcac tcccgaagtc      900

acatgtgttg ttgtcgacgt atctcatgaa gatcctgagg tgaaattcaa ctggtatgta      960

gacggggtcg aagttcataa tgctaagact aagccacgag aagagcaata caactcaacg     1020

tatcgggtgg tgagcgttct gacggttctg caccaagatt ggcttaatgg aaaagagtat     1080

aagtgcaagg tgtccaacaa ggctcttccg gcacccatcg aaaagacgat ttccaaagcg     1140

aaaggccaac ctagggaacc gcaagtttac actttgcccc cgtcaagaga cgaacttacc     1200

aagaatcaag tttccctgac gtgccttgtg aagggcttct accctagcga tatagcagtt     1260

gagtgggaat ctaacggcca gcccgaaaat aattataaga ctactccgcc cgtgctggac     1320

agtgatggtt catttttcct gtattcaaaa ctcactgtgg acaaatctag atggcagcag     1380

ggtaatgtgt tctcttgttc agttatgcac gaggcattgc acaatcacta tacgcaaaaa     1440

agtttgtctc tctctccggg g                                               1461


<210>  3563
<211>  1500
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CTLA-4 2655  PD-L1 303  Fc

<400>  3563
aaggcgatgc acgtagccca gcccgctgtt gttctcgcaa gttctcgcgg catagcctcc       60

ttcgtatgtg agtatgccag tccaggtaag gcaacggagg tacgggtaac tgtactgcgg      120

caggccgatt cccaggttac ggaggtttgt gcggcaacct acatgatggg taacgagctt      180

acatttctcg acgactcaat atgtactggg acctcctcag gaaatcaggt caatctgacc      240

atccaaggtc tgagggcgat ggatacgggt ctttatattt gcaaggttga actcatgtat      300

ccgcctccat actatctggg cattggaaat ggaacacaaa tctatgttat tgacccggag      360

ccgtgtccag atagtgatca gggatccgga gggtctgggg gaggcggttc tgggggtgga      420

ggctcattta ccgtaacggt ccctaaggat ttgtacgtgg ttgagtacgg gagcaatatg      480

acgattgaat gcaagttccc cgtagagaag cagctcgatt tggccgcttt gatagtgtac      540

tgggaaatgg aaggaaaaga catcattcaa ttcgtccacg gtgaagagga tcaaaaagcg      600

caacatagct cctatagaca acgcgcacgc ttgcttaaag accagctgag tcttggtaac      660

gcggcgctgc agattaccga cgtaaaactt caagacgcgg gagtttatcg ctgcatgatt      720

tcctacgggg gtggcgcaga ctataaaagg atcactgtaa aggtaaacgc cggcggaggt      780

ggttccggat ccggtggagg aggctccgag cccaaaagct ccgacaagac tcacacatgc      840

cccccttgtc cagcgcctga agctgagggt gcgccctctg tcttcctttt cccccctaag      900

ccgaaagata ccctgatgat ctcccgcact cccgaagtca catgtgttgt tgtcgacgta      960

tctcatgaag atcctgaggt gaaattcaac tggtatgtag acggggtcga agttcataat     1020

gctaagacta agccacgaga agagcaatac aactcaacgt atcgggtggt gagcgttctg     1080

acggttctgc accaagattg gcttaatgga aaagagtata agtgcaaggt gtccaacaag     1140

gctcttccgg cacccatcga aaagacgatt tccaaagcga aaggccaacc tagggaaccg     1200

caagtttaca ctttgccccc gtcaagagac gaacttacca agaatcaagt ttccctgacg     1260

tgccttgtga agggcttcta ccctagcgat atagcagttg agtgggaatc taacggccag     1320

cccgaaaata attataagac tactccgccc gtgctggaca gtgatggttc atttttcctg     1380

tattcaaaac tcactgtgga caaatctaga tggcagcagg gtaatgtgtt ctcttgttca     1440

gttatgcacg aggcattgca caatcactat acgcaaaaaa gtttgtctct ctctccgggg     1500


<210>  3564
<211>  1500
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  CTLA-4 2655  Fc

<400>  3564
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggatc cggagggtct      360

gggggaggcg gttctggggg tggaggctca aaggcgatgc acgtagccca gcccgctgtt      420

gttctcgcaa gttctcgcgg catagcctcc ttcgtatgtg agtatgccag tccaggtaag      480

gcaacggagg tacgggtaac tgtactgcgg caggccgatt cccaggttac ggaggtttgt      540

gcggcaacct acatgatggg taacgagctt acatttctcg acgactcaat atgtactggg      600

acctcctcag gaaatcaggt caatctgacc atccaaggtc tgagggcgat ggatacgggt      660

ctttatattt gcaaggttga actcatgtat ccgcctccat actatctggg cattggaaat      720

ggaacacaaa tctatgttat tgacccggag ccgtgtccag atagtgatca gggcggaggt      780

ggttccggat ccggtggagg aggctccgag cccaaaagct ccgacaagac tcacacatgc      840

cccccttgtc cagcgcctga agctgagggt gcgccctctg tcttcctttt cccccctaag      900

ccgaaagata ccctgatgat ctcccgcact cccgaagtca catgtgttgt tgtcgacgta      960

tctcatgaag atcctgaggt gaaattcaac tggtatgtag acggggtcga agttcataat     1020

gctaagacta agccacgaga agagcaatac aactcaacgt atcgggtggt gagcgttctg     1080

acggttctgc accaagattg gcttaatgga aaagagtata agtgcaaggt gtccaacaag     1140

gctcttccgg cacccatcga aaagacgatt tccaaagcga aaggccaacc tagggaaccg     1200

caagtttaca ctttgccccc gtcaagagac gaacttacca agaatcaagt ttccctgacg     1260

tgccttgtga agggcttcta ccctagcgat atagcagttg agtgggaatc taacggccag     1320

cccgaaaata attataagac tactccgccc gtgctggaca gtgatggttc atttttcctg     1380

tattcaaaac tcactgtgga caaatctaga tggcagcagg gtaatgtgtt ctcttgttca     1440

gttatgcacg aggcattgca caatcactat acgcaaaaaa gtttgtctct ctctccgggg     1500


<210>  3565
<211>  1497
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CTLA-4 3037  PD-L1 303 Fc

<400>  3565
aaagcgatgc acgtcgccca gcctgccgtc gtactcgcta gctcacgcgg catcgctagt       60

ttcgtatgcg aatatgcctc tccatggaaa gcgaccgagg tcagagttac tgtactgaga      120

caagctgatt cacaagtgac tgaggtctgc gctgctactt atatgatggg gagcgagctg      180

actttccctg atgactcaat ctgtaccggc accagcagtg ggaaccaagt aaatcttact      240

attcgaggac tgagggcaat ggacacggga ctttacattt gtaaggtcga gcagatgtac      300

ccgccacctt acctcctcgg aatcggtaat ggtacgcaaa tttatgttat agatcctgaa      360

ccgtgccccg attccgacgg atccggaggg tctgggggag gcggttctgg gggtggaggc      420

tcatttaccg taacggtccc taaggatttg tacgtggttg agtacgggag caatatgacg      480

attgaatgca agttccccgt agagaagcag ctcgatttgg ccgctttgat agtgtactgg      540

gaaatggaag gaaaagacat cattcaattc gtccacggtg aagaggatca aaaagcgcaa      600

catagctcct atagacaacg cgcacgcttg cttaaagacc agctgagtct tggtaacgcg      660

gcgctgcaga ttaccgacgt aaaacttcaa gacgcgggag tttatcgctg catgatttcc      720

tacgggggtg gcgcagacta taaaaggatc actgtaaagg taaacgccgg cggaggtggt      780

tccggatccg gtggaggagg ctccgagccc aaaagctccg acaagactca cacatgcccc      840

ccttgtccag cgcctgaagc tgagggtgcg ccctctgtct tccttttccc ccctaagccg      900

aaagataccc tgatgatctc ccgcactccc gaagtcacat gtgttgttgt cgacgtatct      960

catgaagatc ctgaggtgaa attcaactgg tatgtagacg gggtcgaagt tcataatgct     1020

aagactaagc cacgagaaga gcaatacaac tcaacgtatc gggtggtgag cgttctgacg     1080

gttctgcacc aagattggct taatggaaaa gagtataagt gcaaggtgtc caacaaggct     1140

cttccggcac ccatcgaaaa gacgatttcc aaagcgaaag gccaacctag ggaaccgcaa     1200

gtttacactt tgcccccgtc aagagacgaa cttaccaaga atcaagtttc cctgacgtgc     1260

cttgtgaagg gcttctaccc tagcgatata gcagttgagt gggaatctaa cggccagccc     1320

gaaaataatt ataagactac tccgcccgtg ctggacagtg atggttcatt tttcctgtat     1380

tcaaaactca ctgtggacaa atctagatgg cagcagggta atgtgttctc ttgttcagtt     1440

atgcacgagg cattgcacaa tcactatacg caaaaaagtt tgtctctctc tccgggg        1497


<210>  3566
<211>  1497
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  CTLA-4 3037  Fc

<400>  3566
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggatc cggagggtct      360

gggggaggcg gttctggggg tggaggctca aaagcgatgc acgtcgccca gcctgccgtc      420

gtactcgcta gctcacgcgg catcgctagt ttcgtatgcg aatatgcctc tccatggaaa      480

gcgaccgagg tcagagttac tgtactgaga caagctgatt cacaagtgac tgaggtctgc      540

gctgctactt atatgatggg gagcgagctg actttccctg atgactcaat ctgtaccggc      600

accagcagtg ggaaccaagt aaatcttact attcgaggac tgagggcaat ggacacggga      660

ctttacattt gtaaggtcga gcagatgtac ccgccacctt acctcctcgg aatcggtaat      720

ggtacgcaaa tttatgttat agatcctgaa ccgtgccccg attccgacgg cggaggtggt      780

tccggatccg gtggaggagg ctccgagccc aaaagctccg acaagactca cacatgcccc      840

ccttgtccag cgcctgaagc tgagggtgcg ccctctgtct tccttttccc ccctaagccg      900

aaagataccc tgatgatctc ccgcactccc gaagtcacat gtgttgttgt cgacgtatct      960

catgaagatc ctgaggtgaa attcaactgg tatgtagacg gggtcgaagt tcataatgct     1020

aagactaagc cacgagaaga gcaatacaac tcaacgtatc gggtggtgag cgttctgacg     1080

gttctgcacc aagattggct taatggaaaa gagtataagt gcaaggtgtc caacaaggct     1140

cttccggcac ccatcgaaaa gacgatttcc aaagcgaaag gccaacctag ggaaccgcaa     1200

gtttacactt tgcccccgtc aagagacgaa cttaccaaga atcaagtttc cctgacgtgc     1260

cttgtgaagg gcttctaccc tagcgatata gcagttgagt gggaatctaa cggccagccc     1320

gaaaataatt ataagactac tccgcccgtg ctggacagtg atggttcatt tttcctgtat     1380

tcaaaactca ctgtggacaa atctagatgg cagcagggta atgtgttctc ttgttcagtt     1440

atgcacgagg cattgcacaa tcactatacg caaaaaagtt tgtctctctc tccgggg        1497


<210>  3567
<211>  1482
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  Fc - CTLA-4 3037

<400>  3567
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccgggtc tgggggaggc      360

ggttctgagc ccaaaagctc cgacaagact cacacatgcc ccccttgtcc agcgcctgaa      420

gctgagggtg cgccctctgt cttccttttc ccccctaagc cgaaagatac cctgatgatc      480

tcccgcactc ccgaagtcac atgtgttgtt gtcgacgtat ctcatgaaga tcctgaggtg      540

aaattcaact ggtatgtaga cggggtcgaa gttcataatg ctaagactaa gccacgagaa      600

gagcaataca actcaacgta tcgggtggtg agcgttctga cggttctgca ccaagattgg      660

cttaatggaa aagagtataa gtgcaaggtg tccaacaagg ctcttccggc acccatcgaa      720

aagacgattt ccaaagcgaa aggccaacct agggaaccgc aagtttacac tttgcccccg      780

tcaagagacg aacttaccaa gaatcaagtt tccctgacgt gccttgtgaa gggcttctac      840

cctagcgata tagcagttga gtgggaatct aacggccagc ccgaaaataa ttataagact      900

actccgcccg tgctggacag tgatggttca tttttcctgt attcaaaact cactgtggac      960

aaatctagat ggcagcaggg taatgtgttc tcttgttcag ttatgcacga ggcattgcac     1020

aatcactata cgcaaaaaag tttgtctctc tctccggggg gtggaggtgg ctctggaggt     1080

ggtggaagcg gtggcggtgg tagcaaagcg atgcacgtcg cccagcctgc cgtcgtactc     1140

gctagctcac gcggcatcgc tagtttcgta tgcgaatatg cctctccatg gaaagcgacc     1200

gaggtcagag ttactgtact gagacaagct gattcacaag tgactgaggt ctgcgctgct     1260

acttatatga tggggagcga gctgactttc cctgatgact caatctgtac cggcaccagc     1320

agtgggaacc aagtaaatct tactattcga ggactgaggg caatggacac gggactttac     1380

atttgtaagg tcgagcagat gtacccgcca ccttacctcc tcggaatcgg taatggtacg     1440

caaatttatg ttatagatcc tgaaccgtgc cccgattccg ac                        1482


<210>  3568
<211>  387
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303

<400>  3568
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccgatta caaggatgac      360

gacgataagc accatcatca ccatcac                                          387


<210>  3569
<211>  360
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L2 1417

<400>  3569
ttattcacag tgacagtccc taaggaactg tacataatag agcaaggcag caatgtgacc       60

ctggaatgca actttgacac tggaagtcat gtgaaccttg gagcaataac agccagtttg      120

caaaaggtgg aaaatgatgc ttccccacac cgtgaaagag ccactttgct ggaggagcag      180

ctgcccctag ggagggcctt attccacata cctcaagtcc aagtgaggga cgaaggacag      240

tacaggtgca taatcatcta tggggacgcc tgggactaca agtacctgac tctgaaagtc      300

aaagctggat cagattacaa ggatgacgac gataagggat ctcaccatca tcaccatcac      360


<210>  3570
<211>  408
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ICOSL 2266

<400>  3570
gatactcagg agaaggaagt cagagcgatg gtaggcagcg acgtggagct cagctgcgct       60

tgccctgaag gaagccgttt tgatttaaat gatgtttacg tatattggca aaccagtgag      120

tcgaaaaccg tggtgaccta ccacatccca cagcacagct ccttggaaaa cgtggacagc      180

cgctaccgga accgagccct gatgtcaccg gccggcatgc tgcggggcga cttctccctg      240

cgcttgttca acgtcacccc ccaggacgag cagaagtttc actgcctggt gttgagccga      300

tccctgggat tccaggaggt tttgagcgtt gaggttacac tgcatgtggc agcaaacttc      360

agcgtggatt acaaggatga cgacgataag caccatcatc accatcac                   408


<210>  3571
<211>  408
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ICOSL 2264

<400>  3571
gatactcagg agaaggaagt cagagcgatg gtaggcagcg acgtggagct cagctgcgct       60

tgccctgaag gaagccgttt tgatttaaat gatgtttacg tatattggca aaccagtgag      120

tcgaaaaccg tggtgaccta ccacatccca cagcacagct ccttggaata cgtggacagc      180

cgctaccgga accgagccct gatgtcaccg gccggcatgc tgcggggcga cttctccctg      240

cgcttgttca acgtcacccc ccaggacgag cagaagtttc actgcctggt gttgagccga      300

tccctgggat tccaggaggt tttgagcgtt gaggttacac tgcatgtggc agcaaacttc      360

agcgtggatt acaaggatga cgacgataag caccatcatc accatcac                   408


<210>  3572
<211>  1092
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CTLA-4 3037  Fc

<400>  3572
aaagcgatgc acgtcgccca gcctgccgtc gtactcgcta gctcacgcgg catcgctagt       60

ttcgtatgcg aatatgcctc tccatggaaa gcgaccgagg tcagagttac tgtactgaga      120

caagctgatt cacaagtgac tgaggtctgc gctgctactt atatgatggg gagcgagctg      180

actttccctg atgactcaat ctgtaccggc accagcagtg ggaaccaagt aaatcttact      240

attcgaggac tgagggcaat ggacacggga ctttacattt gtaaggtcga gcagatgtac      300

ccgccacctt acctcctcgg aatcggtaat ggtacgcaaa tttatgttat agatcctgaa      360

ccgtgccccg attccgacgg atccggtgga ggagggtcag agcccaaaag ctccgacaag      420

actcacacat gccccccttg tccagcgcct gaagctgagg gtgcgccctc tgtcttcctt      480

ttccccccta agccgaaaga taccctgatg atctcccgca ctcccgaagt cacatgtgtt      540

gttgtcgacg tatctcatga agatcctgag gtgaaattca actggtatgt agacggggtc      600

gaagttcata atgctaagac taagccacga gaagagcaat acaactcaac gtatcgggtg      660

gtgagcgttc tgacggttct gcaccaagat tggcttaatg gaaaagagta taagtgcaag      720

gtgtccaaca aggctcttcc ggcacccatc gaaaagacga tttccaaagc gaaaggccaa      780

cctagggaac cgcaagttta cactttgccc ccgtcaagag acgaacttac caagaatcaa      840

gtttccctga cgtgccttgt gaagggcttc taccctagcg atatagcagt tgagtgggaa      900

tctaacggcc agcccgaaaa taattataag actactccgc ccgtgctgga cagtgatggt      960

tcatttttcc tgtattcaaa actcactgtg gacaaatcta gatggcagca gggtaatgtg     1020

ttctcttgtt cagttatgca cgaggcattg cacaatcact atacgcaaaa aagtttgtct     1080

ctctctccgg gg                                                         1092


<210>  3573
<211>  1092
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CTLA-4 36  Fc

<400>  3573
aaagcgatgc acgtcgccca gcctgctgtc gtactcgcta gctcacgcgg catcgcaagt       60

ttcgtatgcg aatatgcctc tccaggaaaa gcgaccgagg tcagagttac tgtactgaga      120

caagctgatt cacaagtgac tgaggtctgc gctgctactt atatgatggg gaacgagctg      180

actttccttg atgactcaat ctgtaccggc accagcagtg ggaaccaagt aaatcttact      240

attcaaggac tgagggcaat ggacacggga ctttacattt gtaaggtcga gctgatgtac      300

ccgccacctt actacctcgg aatcggtaat ggtacgcaaa tttatgttat agatcctgaa      360

ccgtgccccg attccgacgg atccggtgga ggagggtcag agcccaaaag ctccgacaag      420

actcacacat gccccccttg tccagcgcct gaagctgagg gtgcgccctc tgtcttcctt      480

ttccccccta agccgaaaga taccctgatg atctcccgca ctcccgaagt cacatgtgtt      540

gttgtcgacg tatctcatga agatcctgag gtgaaattca actggtatgt agacggggtc      600

gaagttcata atgctaagac taagccacga gaagagcaat acaactcaac gtatcgggtg      660

gtgagcgttc tgacggttct gcaccaagat tggcttaatg gaaaagagta taagtgcaag      720

gtgtccaaca aggctcttcc ggcacccatc gaaaagacga tttccaaagc gaaaggccaa      780

cctagggaac cgcaagttta cactttgccc ccgtcaagag acgaacttac caagaatcaa      840

gtttccctga cgtgccttgt gaagggcttc taccctagcg atatagcagt tgagtgggaa      900

tctaacggcc agcccgaaaa taattataag actactccgc ccgtgctgga cagtgatggt      960

tcatttttcc tgtattcaaa actcactgtg gacaaatcta gatggcagca gggtaatgtg     1020

ttctcttgtt cagttatgca cgaggcattg cacaatcact atacgcaaaa aagtttgtct     1080

ctctctccgg gg                                                         1092


<210>  3574
<211>  1059
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303   Fc

<400>  3574
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggatc cggtggagga      360

gggtcagagc ccaaaagctc cgacaagact cacacatgcc ccccttgtcc agcgcctgaa      420

gctgagggtg cgccctctgt cttccttttc ccccctaagc cgaaagatac cctgatgatc      480

tcccgcactc ccgaagtcac atgtgttgtt gtcgacgtat ctcatgaaga tcctgaggtg      540

aaattcaact ggtatgtaga cggggtcgaa gttcataatg ctaagactaa gccacgagaa      600

gagcaataca actcaacgta tcgggtggtg agcgttctga cggttctgca ccaagattgg      660

cttaatggaa aagagtataa gtgcaaggtg tccaacaagg ctcttccggc acccatcgaa      720

aagacgattt ccaaagcgaa aggccaacct agggaaccgc aagtttacac tttgcccccg      780

tcaagagacg aacttaccaa gaatcaagtt tccctgacgt gccttgtgaa gggcttctac      840

cctagcgata tagcagttga gtgggaatct aacggccagc ccgaaaataa ttataagact      900

actccgcccg tgctggacag tgatggttca tttttcctgt attcaaaact cactgtggac      960

aaatctagat ggcagcaggg taatgtgttc tcttgttcag ttatgcacga ggcattgcac     1020

aatcactata cgcaaaaaag tttgtctctc tctccgggg                            1059


<210>  3575
<211>  1308
<212>  DNA
<213>  Artificial sequence

<220>
<223>  huPDL2-Fc

<400>  3575
ttattcacag tgacagtccc taaggaactg tacataatag agcatggcag caatgtgacc       60

ctggaatgca actttgacac tggaagtcat gtgaaccttg gagcaataac agccagtttg      120

caaaaggtgg aaaatgatac atccccacac cgtgaaagag ccactttgct ggaggagcag      180

ctgcccctag ggaaggcctc gttccacata cctcaagtcc aagtgaggga cgaaggacag      240

taccaatgca taatcatcta tggggtcgcc tgggactaca agtacctgac tctgaaagtc      300

aaagcttcct acaggaaaat aaacactcac atcctaaagg ttccagaaac agatgaggta      360

gagctcacct gccaggctac aggttatcct ctggcagaag tatcctggcc aaacgtcagc      420

gttcctgcca acaccagcca ctccaggacc cctgaaggcc tctaccaggt caccagtgtt      480

ctgcgcctaa agccaccccc tggcagaaac ttcagctgtg tgttctggaa tactcacgtg      540

agggaactta ctttggccag cattgacctt caaagtcaga tggaacccag gacccatcca      600

actgcggccg cagagcccaa atcttctgac aaaactcaca catgcccacc gtgcccagca      660

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      720

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      780

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      840

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      900

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc      960

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1020

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1080

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1140

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1200

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1260

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaag                  1308


<210>  3576
<211>  720
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Stuffer_AAA_ Knob Fc

<400>  3576
cacatgtctt cggtaagtgc acaagagccc aaaagctccg acaagactca cacatgcccc       60

ccttgtccag cgcctgaagc tgagggtgcg ccctctgtct tccttttccc ccctaagccg      120

aaagataccc tgatgatctc ccgcactccc gaagtcacat gtgttgttgt cgacgtatct      180

catgaagatc ctgaggtgaa attcaactgg tatgtagacg gggtcgaagt tcataatgct      240

aagactaagc cacgagaaga gcaatacaac tcaacgtatc gggtggtgag cgttctgacg      300

gttctgcacc aagattggct taatggaaaa gagtataagt gcaaggtgtc caacaaggct      360

cttccggcac ccatcgaaaa gacgatttcc aaagcgaaag gccaacctag ggaaccgcaa      420

gtttacactt tgcccccgtg cagagaagaa atgaccaaga atcaagtttc cctgtggtgc      480

cttgtgaagg gcttctaccc tagcgatata gcagttgagt gggaatctaa cggccagccc      540

gaaaataatt ataagactac tccgcccgtg ctggacagtg atggttcatt tttcctgtat      600

tcaaaactca ctgtggacaa atctagatgg cagcagggta atgtgttctc ttgttcagtt      660

atgcacgagg cattgcacaa tcactatacg caaaaaagtt tgtctctctc tccggggaag      720


<210>  3577
<211>  1101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303  Fc

<400>  3577
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggatc cggagggtct      360

gggggaggcg gttctggggg tggaggctca gagcccaaaa gctccgacaa gactcacaca      420

tgcccccctt gtccagcgcc tgaagctgag ggtgcgccct ctgtcttcct tttcccccct      480

aagccgaaag ataccctgat gatctcccgc actcccgaag tcacatgtgt tgttgtcgac      540

gtatctcatg aagatcctga ggtgaaattc aactggtatg tagacggggt cgaagttcat      600

aatgctaaga ctaagccacg agaagagcaa tacaactcaa cgtatcgggt ggtgagcgtt      660

ctgacggttc tgcaccaaga ttggcttaat ggaaaagagt ataagtgcaa ggtgtccaac      720

aaggctcttc cggcacccat cgaaaagacg atttccaaag cgaaaggcca acctagggaa      780

ccgcaagttt gcactttgcc cccgtcaaga gaagaaatga ccaagaatca agtttccctg      840

tcttgcgcag tgaagggctt ctaccctagc gatatagcag ttgagtggga atctaacggc      900

cagcccgaaa ataattataa gactactccg cccgtgctgg acagtgatgg ttcatttttc      960

ctggtttcaa aactcactgt ggacaaatct agatggcagc agggtaatgt gttctcttgt     1020

tcagttatgc acgaggcatt gcacaatcac tatacgcaaa aaagtttgtc tctctctccg     1080

gggcaccatc atcaccatca c                                               1101


<210>  3578
<211>  798
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303   ICOSL 2244

<400>  3578
tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt       60

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      120

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      180

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      240

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      300

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggatc cggagggtct      360

gggggaggcg gttctggggg tggaggctca gatactcagg agaaggaagt cagagcgatg      420

gtaggcagcg acgtggagct cagctgcgct tgccctgaag gaagccgttt tgatttaaat      480

gatgtttacg tatattggca aaccagtgag tcgaaaaccg tggtgaccta ccacatccca      540

cagcacagct ccttggaata tgtggacagc cgctaccgga accgagccct gatgtcaccg      600

gccggcatgc tgcggggcga cttctccctg cgcttgttca acgtcacccc ccaggacgag      660

cagaagtttc actgcctggt gttgagcaga tccctgggat tccaggaggt tttgagcgtt      720

gaggttacac tgcatgtggc agcaaacttc agcgtggatt acaaggatga cgacgataag      780

caccatcatc accatcac                                                    798


<210>  3579
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc (C220S/L234A/L235E/G237A/E356D/M358L )

<400>  3579

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  3580
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Wildtype CD80 IgV

<400>  3580

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  3581
<211>  1062
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L2 1417_GSGGS_2xG4S_ Hole Fc_His

<400>  3581
ttattcacag tgactgttcc gaaagagttg tatataatcg agcaagggag taatgttacc       60

ctggaatgca attttgacac cgggtcacac gtcaacctcg gagcgattac tgcttctttg      120

caaaaagttg aaaacgacgc gtccccccat agggaaaggg cgacccttct ggaggagcag      180

ttgccccttg gcagggcact ctttcacatt ccccaggtgc aagtcaggga cgaggggcaa      240

taccgctgca tcataattta cggggacgcg tgggactaca agtacttgac tctcaaagtt      300

aaagctggat ccggagggtc tgggggaggc ggttctgggg gtggaggctc agagcccaaa      360

agctccgaca agactcacac atgcccccct tgtccagcgc ctgaagctga gggtgcgccc      420

tctgtcttcc ttttcccccc taagccgaaa gataccctga tgatctcccg cactcccgaa      480

gtcacatgtg ttgttgtcga cgtatctcat gaagatcctg aggtgaaatt caactggtat      540

gtagacgggg tcgaagttca taatgctaag actaagccac gagaagagca atacaactca      600

acgtatcggg tggtgagcgt tctgacggtt ctgcaccaag attggcttaa tggaaaagag      660

tataagtgca aggtgtccaa caaggctctt ccggcaccca tcgaaaagac gatttccaaa      720

gcgaaaggcc aacctaggga accgcaagtt tgcactttgc ccccgtcaag agaagaaatg      780

accaagaatc aagtttccct gtcttgcgca gtgaagggct tctaccctag cgatatagca      840

gttgagtggg aatctaacgg ccagcccgaa aataattata agactactcc gcccgtgctg      900

gacagtgatg gttcattttt cctggtttca aaactcactg tggacaaatc tagatggcag      960

cagggtaatg tgttctcttg ttcagttatg cacgaggcat tgcacaatca ctatacgcaa     1020

aaaagtttgt ctctctctcc ggggcaccat catcaccatc ac                        1062


<210>  3582
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T89A/L98Q/M99L/Y105L/L106I/Y115N/E120D/C122P/D124P/S125I/D126P 
       ECD

<400>  3582

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Asn Val Ile Asp Pro Asp Pro Pro Pro Pro Ile Pro 
        115                 120                 125     


<210>  3583
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  N58S/L63P/T71A/S72G/L98Q/M99L/Y105L/D124I/S125P/D126T ECD

<400>  3583

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Ala Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Ile Pro Thr 
        115                 120                 125     


<210>  3584
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  R16G/E33M/N58S/E59G/L63P/L98Q/Y105L/E120D/C122P/D124P/S125I/D126P
       ECD

<400>  3584

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Gly 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Met Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Gly Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Asp Pro Pro Pro Pro Ile Pro 
        115                 120                 125     


<210>  3585
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/L63P/S72G/L98Q/Y105L/P121S/D126T ECD

<400>  3585

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Ser Cys Pro Asp Ser Thr 
        115                 120                 125     


<210>  3586
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12H/E33M/L98Q/Y105L ECD

<400>  3586

Lys Ala Met His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Met Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3587
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/M87V/L98Q/Y105L ECD

<400>  3587

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3588
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  I18T/A26T/M55T/M56K/L63P/L98Q/M99L/Y105L ECD

<400>  3588

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3589
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  I18T/A26T/M56K/L63P/L98Q/Y105L ECD

<400>  3589

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3590
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/L63P/L98Q ECD

<400>  3590

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3591
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/L63P/Y105L ECD

<400>  3591

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3592
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/M87V/L98Q ECD

<400>  3592

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3593
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/M87V/Y105L ECD

<400>  3593

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3594
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/L98Q/Y105L ECD

<400>  3594

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3595
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/M87V/L98Q/Y105L ECD

<400>  3595

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3596
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/L63P/M87V/L98Q/Y105L ECD

<400>  3596

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3597
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/N58S/L63P/M87V/L98Q/Y105L ECD

<400>  3597

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3598
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  M56K/N58S/L63P/M87V/L98Q/Y105L ECD

<400>  3598

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3599
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/L98Q/Y105L ECD

<400>  3599

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3600
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/M99L/Y105L ECD

<400>  3600

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3601
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/L98Q/M99L  ECD

<400>  3601

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3602
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/M99L ECD

<400>  3602

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3603
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/G29W/M56T/L98Q ECD

<400>  3603

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3604
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/G29W/M56T/Y105L ECD

<400>  3604

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3605
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/G29W/L98Q/Y105L ECD

<400>  3605

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3606
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/M56T/L98Q/Y105L ECD

<400>  3606

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3607
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/M56T/L98Q/Y105L ECD

<400>  3607

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3608
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/G29W/L98Q/Y105L ECD

<400>  3608

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3609
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/L98Q/Y105L ECD

<400>  3609

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3610
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  R16H/L98Q/Y105L ECD

<400>  3610

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3611
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/L98Q/Y105L ECD

<400>  3611

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3612
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  M56T/L98Q/Y105L ECD

<400>  3612

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3613
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/G29W/M56T/S72G/L98Q/Y105L ECD

<400>  3613

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3614
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/M56T/S72G/L98Q/Y105L ECD

<400>  3614

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3615
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T89A/L98Q/M99L/Y105L/L106I/Y115N/E120D/C122P/D124P/S125I/D126P 
       IgV domain

<400>  3615

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3616
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  N58S/L63P/T71A/S72G/L98Q/M99L/Y105L/D124I/S125P/D126T IgV domain

<400>  3616

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Ala Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3617
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  R16G/E33M/N58S/E59G/L63P/L98Q/Y105L/E120D/C122P/D124P/S125I/D126P
       IgV

<400>  3617

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Gly Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Met Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Gly Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3618
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/L63P/S72G/L98Q/Y105L/P121S/D126T IgV domain

<400>  3618

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3619
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12H/E33M/L98Q/Y105L IgV domain

<400>  3619

His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Met Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3620
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/M87V/L98Q/Y105L IgV domain

<400>  3620

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3621
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  I18T/A26T/M55T/M56K/L63P/L98Q/ M99L/Y105L IgV domain

<400>  3621

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3622
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  I18T/A26T/M56K/L63P/L98Q/Y105L IgV domain

<400>  3622

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3623
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/L63P/L98Q IgV domain

<400>  3623

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3624
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/L63P/Y105L IgV domain

<400>  3624

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3625
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/M87V/L98Q IgV domain

<400>  3625

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3626
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/M87V/Y105L IgV domain

<400>  3626

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3627
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/L98Q/Y105L IgV domain

<400>  3627

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3628
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/M87V/L98Q/Y105L IgV domain

<400>  3628

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3629
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/L63P/M87V/L98Q/Y105L IgV domain

<400>  3629

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3630
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/N58S/L63P/M87V/L98Q/Y105L IgV domain

<400>  3630

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3631
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  M56K/N58S/L63P/M87V/L98Q/Y105L IgV domain

<400>  3631

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3632
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/L98Q/Y105L IgV domain

<400>  3632

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3633
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/M99L/Y105L IgV domain

<400>  3633

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3634
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/L98Q/M99L  IgV domain

<400>  3634

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3635
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/M99L IgV domain

<400>  3635

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3636
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/G29W/M56T/L98Q IgV domain

<400>  3636

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  3637
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/G29W/M56T/Y105L IgV domain

<400>  3637

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3638
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/G29W/L98Q/Y105L IgV domain

<400>  3638

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3639
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/M56T/L98Q/Y105L IgV domain

<400>  3639

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3640
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/M56T/L98Q/Y105L IgV domain

<400>  3640

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3641
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/G29W/L98Q/Y105L IgV domain

<400>  3641

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3642
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/L98Q/Y105L IgV domain

<400>  3642

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3643
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  R16H/L98Q/Y105L IgV domain

<400>  3643

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3644
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/L98Q/Y105L IgV domain

<400>  3644

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3645
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  M56T/L98Q/Y105L IgV domain

<400>  3645

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3646
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>   L12F/R16H/G29W/M56T/S72G/L98Q/Y105L IgV domain

<400>  3646

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3647
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/M56T/S72G/L98Q/Y105L IgV domain

<400>  3647

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  3648
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  I18T, T61R, L63P, S72G, L98Q, M99L, P102L, Y105L ECD

<400>  3648

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Arg Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Leu Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3649
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  I18T, T61R, L63P, S72G, L98Q, M99L, P102L, Y105L IgV domain

<400>  3649

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Arg Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Leu Pro Tyr Leu 
            100         


<210>  3650
<211>  94
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(94)
<223>  CD58 wild type

<400>  3650

Ser Gln Gln Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His Val 
1               5                   10                  15      


Pro Ser Asn Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys Asp 
            20                  25                  30          


Lys Val Ala Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser Phe 
        35                  40                  45              


Lys Asn Arg Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr 
    50                  55                  60                  


Asn Leu Thr Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn 
65                  70                  75                  80  


Ile Thr Asp Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser 
                85                  90                  


<210>  3651
<211>  1560
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CTLA4 3060 - CD155 665 - Fc

<400>  3651
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctaaa       60

gcgatgcacg tcgcccagcc tgctgtcgta ttcgccagct cacacggcat cgcaagtttc      120

gtatgcgaat atgcctctcc atggaaagcg accgaggtca gagttactgt actgagacaa      180

gctgattcac aagtgactga ggtctgcgct gctacttata tgacggggaa cgagctgact      240

ttccttgatg actcaatctg taccggcacc agcagtggga accaagtaaa tcttactatt      300

caaggactga gggcaatgga cacgggactt tacatttgta aggtcgagca gatgtacccg      360

ccaccttacc tcctcggaat cggtaatggt acgcaaattt atgttataga tcctgaaccg      420

tgccccgatt ccgacggagg tggtggatca ggtggaggag gttccggagg aggtggatct      480

tggccacccc caggaaccgg ggacgtcgtc gtgcaggcgc ccacccaggt gtccggcttc      540

ttgggcgact ccgtgacgct gccctgctac ctacaggtgc ccaacatgga ggtgacgcat      600

gtgtcacagc tgacttgggc gcggcatggt gaatctggca gcatggccgt cttccaccaa      660

acgcagggcc cctggtatgc ggagtccaaa cggctggaat tcgtggcagc cagactgggc      720

gcggagctgc ggaatgcctc gctgagggtg ttcgggttgc gcgcagagga tgaaggcaac      780

tacacctgcc agttcgtcac gttcccgcag cgcagcagga gcgtggatat ctggctccga      840

gtgcttggat ccggtggagg agggtcagag cccaaaagct ccgacaagac tcacacatgc      900

cccccttgtc cagcgcctga agctgagggt gcgccctctg tcttcctttt cccccctaag      960

ccgaaagata ccctgatgat ctcccgcact cccgaagtca catgtgttgt tgtcgacgta     1020

tctcatgaag atcctgaggt gaaattcaac tggtatgtag acggggtcga agttcataat     1080

gctaagacta agccacgaga agagcaatac aactcaacgt atcgggtggt gagcgttctg     1140

acggttctgc accaagattg gcttaatgga aaagagtata agtgcaaggt gtccaacaag     1200

gctcttccgg cacccatcga aaagacgatt tccaaagcga aaggccaacc tagggaaccg     1260

caagtttaca ctttgccccc gtcaagagac gaacttacca agaatcaagt ttccctgacg     1320

tgccttgtga agggcttcta ccctagcgat atagcagttg agtgggaatc taacggccag     1380

cccgaaaata attataagac tactccgccc gtgctggaca gtgatggttc atttttcctg     1440

tattcaaaac tcactgtgga caaatctaga tggcagcagg gtaatgtgtt ctcttgttca     1500

gttatgcacg aggcattgca caatcactat acgcaaaaaa gtttgtctct ctctccgggg     1560


<210>  3652
<211>  501
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CTLA4 3060 - CD155 665 - Fc

<400>  3652

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Trp Pro Pro 
    130                 135                 140                 


Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
145                 150                 155                 160 


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
                165                 170                 175     


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
            180                 185                 190         


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Trp Tyr Ala 
        195                 200                 205             


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
    210                 215                 220                 


Arg Asn Ala Ser Leu Arg Val Phe Gly Leu Arg Ala Glu Asp Glu Gly 
225                 230                 235                 240 


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
                245                 250                 255     


Asp Ile Trp Leu Arg Val Leu Gly Ser Gly Gly Gly Gly Ser Glu Pro 
            260                 265                 270         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly 
            500     


<210>  3653
<211>  1560
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD155 665 - CTLA4 3037 - Fc

<400>  3653
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgcttgg       60

ccacccccag gaaccgggga cgtcgtcgtg caggcgccca cccaggtgtc cggcttcttg      120

ggcgactccg tgacgctgcc ctgctaccta caggtgccca acatggaggt gacgcatgtg      180

tcacagctga cttgggcgcg gcatggtgaa tctggcagca tggccgtctt ccaccaaacg      240

cagggcccct ggtatgcgga gtccaaacgg ctggaattcg tggcagccag actgggcgcg      300

gagctgcgga atgcctcgct gagggtgttc gggttgcgcg cagaggatga aggcaactac      360

acctgccagt tcgtcacgtt cccgcagcgc agcaggagcg tggatatctg gctccgagtg      420

cttggaggtg gtggatcagg tggaggaggt tccggaggag gtggatctaa agcgatgcac      480

gtcgcccagc ctgctgtcgt attcgccagc tcacacggca tcgcaagttt cgtatgcgaa      540

tatgcctctc catggaaagc gaccgaggtc agagttactg tactgagaca agctgattca      600

caagtgactg aggtctgcgc tgctacttat atgacgggga acgagctgac tttccttgat      660

gactcaatct gtaccggcac cagcagtggg aaccaagtaa atcttactat tcaaggactg      720

agggcaatgg acacgggact ttacatttgt aaggtcgagc agatgtaccc gccaccttac      780

ctcctcggaa tcggtaatgg tacgcaaatt tatgttatag atcctgaacc gtgccccgat      840

tccgacggat ccggtggagg agggtcagag cccaaaagct ccgacaagac tcacacatgc      900

cccccttgtc cagcgcctga agctgagggt gcgccctctg tcttcctttt cccccctaag      960

ccgaaagata ccctgatgat ctcccgcact cccgaagtca catgtgttgt tgtcgacgta     1020

tctcatgaag atcctgaggt gaaattcaac tggtatgtag acggggtcga agttcataat     1080

gctaagacta agccacgaga agagcaatac aactcaacgt atcgggtggt gagcgttctg     1140

acggttctgc accaagattg gcttaatgga aaagagtata agtgcaaggt gtccaacaag     1200

gctcttccgg cacccatcga aaagacgatt tccaaagcga aaggccaacc tagggaaccg     1260

caagtttaca ctttgccccc gtcaagagac gaacttacca agaatcaagt ttccctgacg     1320

tgccttgtga agggcttcta ccctagcgat atagcagttg agtgggaatc taacggccag     1380

cccgaaaata attataagac tactccgccc gtgctggaca gtgatggttc atttttcctg     1440

tattcaaaac tcactgtgga caaatctaga tggcagcagg gtaatgtgtt ctcttgttca     1500

gttatgcacg aggcattgca caatcactat acgcaaaaaa gtttgtctct ctctccgggg     1560


<210>  3654
<211>  501
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD155 665 - CTLA4 3037 - Fc

<400>  3654

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Val Phe Gly Leu Arg Ala Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln 
    130                 135                 140                 


Pro Ala Val Val Phe Ala Ser Ser His Gly Ile Ala Ser Phe Val Cys 
145                 150                 155                 160 


Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg Val Thr Val Leu 
                165                 170                 175     


Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met 
            180                 185                 190         


Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr 
        195                 200                 205             


Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met 
    210                 215                 220                 


Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met Tyr Pro Pro Pro 
225                 230                 235                 240 


Tyr Leu Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro 
                245                 250                 255     


Glu Pro Cys Pro Asp Ser Asp Gly Ser Gly Gly Gly Gly Ser Glu Pro 
            260                 265                 270         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    370                 375                 380                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Pro Gly 
            500     


<210>  3655
<211>  1719
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD155 665 - CD155 665 - ICOSL 2264 - ICOSL 2264

<400>  3655
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgcttgg       60

ccacccccag gaaccgggga cgtcgtcgtg caggcgccca cccaggtgtc cggcttcttg      120

ggcgactccg tgacgctgcc ctgctaccta caggtgccca acatggaggt gacgcatgtg      180

tcacagctga cttgggcgcg gcatggtgaa tctggcagca tggccgtctt ccaccaaacg      240

cagggcccct ggtatgcgga gtccaaacgg ctggaattcg tggcagccag actgggcgcg      300

gagctgcgga atgcctcgct gagggtgttc gggttgcgcg cagaggatga aggcaactac      360

acctgccagt tcgtcacgtt cccgcagcgc agcaggagcg tggatatctg gctccgagtg      420

cttggaggtg gtggatcagg tggaggaggt tccggaggag gtggatcttg gccgccccca      480

gggaccggcg atgtagtggt ccaggcgcca acacaggtta gcgggttcct cggcgacagc      540

gtaacactcc cgtgctacct tcaagtacca aacatggaag ttacacacgt ctcccagctc      600

acttgggctc ggcacggaga gtccgggtct atggccgtct tccatcagac tcagggaccg      660

tggtatgctg agagcaaacg gcttgaattt gtggccgcga gattgggcgc cgaattgaga      720

aatgcaagcc tccgagtctt cgggcttagg gctgaggatg aaggcaatta cacctgccag      780

tttgtcacat tcccccaaag gtcccggtct gtggatattt ggctgcgggt ccttggtgga      840

ggtggctctg gaggtggtgg aagcggtggc ggtggtagcg atactcagga gaaggaagtc      900

agagcgatgg taggcagcga cgtggagctc agctgcgctt gccctgaagg aagccgtttt      960

gatttaaatg atgtttacgt atattggcaa accagtgagt cgaaaaccgt ggtgacctac     1020

cacatcccac agcacagctc cttggaatat gtggacagcc gctaccggaa ccgagccctg     1080

atgtcaccgg ccggcatgct gcggggcgac ttctccctgc gcttgttcaa cgtcaccccc     1140

caggacgagc agaagtttca ctgcctggtg ttgagcagat ccctgggatt ccaggaggtt     1200

ttgagcgttg aggttacact gcatgtggca gcaaacttca gcgtgggatc cggagggtct     1260

gggggaggcg gttctggggg tggaggctca gatactcagg aaaaggaagt gagagcaatg     1320

gttgggtcag atgtggaatt gagctgtgca tgccccgaag gaagtagatt cgatctcaat     1380

gatgtctatg tgtactggca aaccagcgag agcaagactg tggtaaccta tcacattccg     1440

caacacagtt cacttgaata tgtggatagc cggtaccgaa atcgggctct tatgtctccg     1500

gcagggatgc ttaggggtga cttttccttg agacttttca acgtcactcc tcaggacgag     1560

cagaaattcc attgtcttgt cctgtctcgg tccttggggt ttcaggaagt gctgtctgta     1620

gaggtgacgc tgcacgtcgc tgctaacttt agcgtgggat ccggtggagg agggtcagac     1680

tataaagatg acgacgacaa acaccatcat caccatcac                            1719


<210>  3656
<211>  554
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD155 665 - CD155 665 - ICOSL 2264 - ICOSL 2264

<400>  3656

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Val Phe Gly Leu Arg Ala Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Trp Pro Pro Pro Gly Thr Gly 
    130                 135                 140                 


Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly Phe Leu Gly Asp 
145                 150                 155                 160 


Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr 
                165                 170                 175     


His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met 
            180                 185                 190         


Ala Val Phe His Gln Thr Gln Gly Pro Trp Tyr Ala Glu Ser Lys Arg 
        195                 200                 205             


Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser 
    210                 215                 220                 


Leu Arg Val Phe Gly Leu Arg Ala Glu Asp Glu Gly Asn Tyr Thr Cys 
225                 230                 235                 240 


Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val Asp Ile Trp Leu 
                245                 250                 255     


Arg Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
        275                 280                 285             


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
    290                 295                 300                 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
305                 310                 315                 320 


Tyr His Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr 
                325                 330                 335     


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
            340                 345                 350         


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
        355                 360                 365             


Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
    370                 375                 380                 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys 
                405                 410                 415     


Glu Val Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys 
            420                 425                 430         


Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln 
        435                 440                 445             


Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln His Ser 
    450                 455                 460                 


Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser 
465                 470                 475                 480 


Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val 
                485                 490                 495     


Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser 
            500                 505                 510         


Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala 
        515                 520                 525             


Ala Asn Phe Ser Val Gly Ser Gly Gly Gly Gly Ser Asp Tyr Lys Asp 
    530                 535                 540                 


Asp Asp Asp Lys His His His His His His 
545                 550                 


<210>  3657
<211>  1719
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD155 665 - ICOSL 2264 - ICOSL 2264 - CD155 665

<400>  3657
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgcttgg       60

ccacccccag gaaccgggga cgtcgtcgtg caggcgccca cccaggtgtc cggcttcttg      120

ggcgactccg tgacgctgcc ctgctaccta caggtgccca acatggaggt gacgcatgtg      180

tcacagctga cttgggcgcg gcatggtgaa tctggcagca tggccgtctt ccaccaaacg      240

cagggcccct ggtatgcgga gtccaaacgg ctggaattcg tggcagccag actgggcgcg      300

gagctgcgga atgcctcgct gagggtgttc gggttgcgcg cagaggatga aggcaactac      360

acctgccagt tcgtcacgtt cccgcagcgc agcaggagcg tggatatctg gctccgagtg      420

cttggaggtg gtggatcagg tggaggaggt accggaggtg gtggatctga tactcaggag      480

aaggaagtca gagcgatggt aggcagcgac gtggagctca gctgcgcttg ccctgaagga      540

agccgttttg atttaaatga tgtttacgta tattggcaaa ccagtgagtc gaaaaccgtg      600

gtgacctacc acatcccaca gcacagctcc ttggaatatg tggacagccg ctaccggaac      660

cgagccctga tgtcaccggc cggcatgctg cggggcgact tctccctgcg cttgttcaac      720

gtcacccccc aggacgagca gaagtttcac tgcctggtgt tgagcagatc cctgggattc      780

caggaggttt tgagcgttga ggttacactg catgtggcag caaacttcag cgtgggtgga      840

ggtggctctg gaggtggtgg aagcggtggc ggtggtagcg atactcagga aaaggaagtg      900

agagcaatgg ttgggtcaga tgtggaattg agctgtgcat gccccgaagg aagtagattc      960

gatctcaatg atgtctatgt gtactggcaa accagcgaga gcaagactgt ggtaacctat     1020

cacattccgc aacacagttc acttgaatat gtggatagcc ggtaccgaaa tcgggctctt     1080

atgtctccgg cagggatgct taggggtgac ttttccttga gacttttcaa cgtcactcct     1140

caggacgagc agaaattcca ttgtcttgtc ctgtctcggt ccttggggtt tcaggaagtg     1200

ctgtctgtag aggtgacgct gcacgtcgct gctaacttta gcgtgggatc cggagggtct     1260

gggggaggcg gttctggggg tggaggctca tggccgcccc cagggaccgg cgatgtagtg     1320

gtccaggcgc caacacaggt tagcgggttc ctcggcgaca gcgtaacact cccgtgctac     1380

cttcaagtac caaacatgga agttacacac gtctcccagc tcacttgggc tcggcacgga     1440

gagtccgggt ctatggccgt cttccatcag actcagggac cgtggtatgc tgagagcaaa     1500

cggcttgaat ttgtggccgc gagattgggc gccgaattga gaaatgcaag cctccgagtc     1560

ttcgggctta gggctgagga tgaaggcaat tacacctgcc agtttgtcac attcccccaa     1620

aggtcccggt ctgtggatat ttggctgcgg gtccttggat ccggtggagg agggtcagac     1680

tataaagatg acgacgacaa acaccatcat caccatcac                            1719


<210>  3658
<211>  554
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD155 665 - ICOSL 2264 - ICOSL 2264 - CD155 665

<400>  3658

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Val Phe Gly Leu Arg Ala Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Thr Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val 
    130                 135                 140                 


Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu 
145                 150                 155                 160 


Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser 
                165                 170                 175     


Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln His Ser Ser Leu 
            180                 185                 190         


Glu Tyr Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala 
        195                 200                 205             


Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
    210                 215                 220                 


Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly 
225                 230                 235                 240 


Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn 
                245                 250                 255     


Phe Ser Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
        275                 280                 285             


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
    290                 295                 300                 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
305                 310                 315                 320 


Tyr His Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr 
                325                 330                 335     


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
            340                 345                 350         


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
        355                 360                 365             


Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
    370                 375                 380                 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Trp Pro Pro Pro Gly 
                405                 410                 415     


Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly Phe Leu 
            420                 425                 430         


Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn Met Glu 
        435                 440                 445             


Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu Ser Gly 
    450                 455                 460                 


Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Trp Tyr Ala Glu Ser 
465                 470                 475                 480 


Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu Arg Asn 
                485                 490                 495     


Ala Ser Leu Arg Val Phe Gly Leu Arg Ala Glu Asp Glu Gly Asn Tyr 
            500                 505                 510         


Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val Asp Ile 
        515                 520                 525             


Trp Leu Arg Val Leu Gly Ser Gly Gly Gly Gly Ser Asp Tyr Lys Asp 
    530                 535                 540                 


Asp Asp Asp Lys His His His His His His 
545                 550                 


<210>  3659
<211>  1464
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD155 665 - CD58 3650 - Fc

<400>  3659
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgcttgg       60

ccacccccag gaaccgggga cgtcgtcgtg caggcgccca cccaggtgtc cggcttcttg      120

ggcgactccg tgacgctgcc ctgctaccta caggtgccca acatggaggt gacgcatgtg      180

tcacagctga cttgggcgcg gcatggtgaa tctggcagca tggccgtctt ccaccaaacg      240

cagggcccct ggtatgcgga gtccaaacgg ctggaattcg tggcagccag actgggcgcg      300

gagctgcgga atgcctcgct gagggtgttc gggttgcgcg cagaggatga aggcaactac      360

acctgccagt tcgtcacgtt cccgcagcgc agcaggagcg tggatatctg gctccgagtg      420

cttggaggtg gtggatcagg tggaggaggt tccggaggag gtggatcttc ccaacaaata      480

tatggtgttg tgtatgggaa tgtaactttc catgtaccaa gcaatgtgcc tttaaaagag      540

gtcctatgga aaaaacaaaa ggataaagtt gcagaactgg aaaattctga attcagagct      600

ttctcatctt ttaaaaatag ggtttattta gacactgtgt caggtagcct cactatctac      660

aacttaacat catcagatga agatgagtat gaaatggaat cgccaaatat tactgatacc      720

atgaagttct ttctttatgt gcttgagtct ggatccggtg gaggagggtc agagcccaaa      780

agctccgaca agactcacac atgcccccct tgtccagcgc ctgaagctga gggtgcgccc      840

tctgtcttcc ttttcccccc taagccgaaa gataccctga tgatctcccg cactcccgaa      900

gtcacatgtg ttgttgtcga cgtatctcat gaagatcctg aggtgaaatt caactggtat      960

gtagacgggg tcgaagttca taatgctaag actaagccac gagaagagca atacaactca     1020

acgtatcggg tggtgagcgt tctgacggtt ctgcaccaag attggcttaa tggaaaagag     1080

tataagtgca aggtgtccaa caaggctctt ccggcaccca tcgaaaagac gatttccaaa     1140

gcgaaaggcc aacctaggga accgcaagtt tacactttgc ccccgtcaag agacgaactt     1200

accaagaatc aagtttccct gacgtgcctt gtgaagggct tctaccctag cgatatagca     1260

gttgagtggg aatctaacgg ccagcccgaa aataattata agactactcc gcccgtgctg     1320

gacagtgatg gttcattttt cctgtattca aaactcactg tggacaaatc tagatggcag     1380

cagggtaatg tgttctcttg ttcagttatg cacgaggcat tgcacaatca ctatacgcaa     1440

aaaagtttgt ctctctctcc gggg                                            1464


<210>  3660
<211>  469
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD155 665 - CD58 3650 - Fc

<400>  3660

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Val Phe Gly Leu Arg Ala Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gln Gln Ile Tyr Gly Val 
    130                 135                 140                 


Val Tyr Gly Asn Val Thr Phe His Val Pro Ser Asn Val Pro Leu Lys 
145                 150                 155                 160 


Glu Val Leu Trp Lys Lys Gln Lys Asp Lys Val Ala Glu Leu Glu Asn 
                165                 170                 175     


Ser Glu Phe Arg Ala Phe Ser Ser Phe Lys Asn Arg Val Tyr Leu Asp 
            180                 185                 190         


Thr Val Ser Gly Ser Leu Thr Ile Tyr Asn Leu Thr Ser Ser Asp Glu 
        195                 200                 205             


Asp Glu Tyr Glu Met Glu Ser Pro Asn Ile Thr Asp Thr Met Lys Phe 
    210                 215                 220                 


Phe Leu Tyr Val Leu Glu Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  3661
<211>  1464
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD58 3650 - CD155 665 - Fc

<400>  3661
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgcttcc       60

caacaaatat atggtgttgt gtatgggaat gtaactttcc atgtaccaag caatgtgcct      120

ttaaaagagg tcctatggaa aaaacaaaag gataaagttg cagaactgga aaattctgaa      180

ttcagagctt tctcatcttt taaaaatagg gtttatttag acactgtgtc aggtagcctc      240

actatctaca acttaacatc atcagatgaa gatgagtatg aaatggaatc gccaaatatt      300

actgatacca tgaagttctt tctttatgtg cttgagtctg gaggtggtgg atcaggtgga      360

ggaggttccg gaggaggtgg atcttggcca cccccaggaa ccggggacgt cgtcgtgcag      420

gcgcccaccc aggtgtccgg cttcttgggc gactccgtga cgctgccctg ctacctacag      480

gtgcccaaca tggaggtgac gcatgtgtca cagctgactt gggcgcggca tggtgaatct      540

ggcagcatgg ccgtcttcca ccaaacgcag ggcccctggt atgcggagtc caaacggctg      600

gaattcgtgg cagccagact gggcgcggag ctgcggaatg cctcgctgag ggtgttcggg      660

ttgcgcgcag aggatgaagg caactacacc tgccagttcg tcacgttccc gcagcgcagc      720

aggagcgtgg atatctggct ccgagtgctt ggatccggtg gaggagggtc agagcccaaa      780

agctccgaca agactcacac atgcccccct tgtccagcgc ctgaagctga gggtgcgccc      840

tctgtcttcc ttttcccccc taagccgaaa gataccctga tgatctcccg cactcccgaa      900

gtcacatgtg ttgttgtcga cgtatctcat gaagatcctg aggtgaaatt caactggtat      960

gtagacgggg tcgaagttca taatgctaag actaagccac gagaagagca atacaactca     1020

acgtatcggg tggtgagcgt tctgacggtt ctgcaccaag attggcttaa tggaaaagag     1080

tataagtgca aggtgtccaa caaggctctt ccggcaccca tcgaaaagac gatttccaaa     1140

gcgaaaggcc aacctaggga accgcaagtt tacactttgc ccccgtcaag agacgaactt     1200

accaagaatc aagtttccct gacgtgcctt gtgaagggct tctaccctag cgatatagca     1260

gttgagtggg aatctaacgg ccagcccgaa aataattata agactactcc gcccgtgctg     1320

gacagtgatg gttcattttt cctgtattca aaactcactg tggacaaatc tagatggcag     1380

cagggtaatg tgttctcttg ttcagttatg cacgaggcat tgcacaatca ctatacgcaa     1440

aaaagtttgt ctctctctcc gggg                                            1464


<210>  3662
<211>  469
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD58 3650 - CD155 665 - Fc

<400>  3662

Ser Gln Gln Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His Val 
1               5                   10                  15      


Pro Ser Asn Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys Asp 
            20                  25                  30          


Lys Val Ala Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser Phe 
        35                  40                  45              


Lys Asn Arg Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr 
    50                  55                  60                  


Asn Leu Thr Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn 
65                  70                  75                  80  


Ile Thr Asp Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Gly Gly 
                85                  90                  95      


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Trp Pro Pro 
            100                 105                 110         


Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly 
        115                 120                 125             


Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn 
    130                 135                 140                 


Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu 
145                 150                 155                 160 


Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Trp Tyr Ala 
                165                 170                 175     


Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu 
            180                 185                 190         


Arg Asn Ala Ser Leu Arg Val Phe Gly Leu Arg Ala Glu Asp Glu Gly 
        195                 200                 205             


Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val 
    210                 215                 220                 


Asp Ile Trp Leu Arg Val Leu Gly Ser Gly Gly Gly Gly Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  3663
<211>  1950
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - CD155 665 - CTLA4 3037 - Fc

<400>  3663
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctttt       60

accgtaacgg tccctaagga tttgtacgtg gttgagtacg ggagcaatat gacgattgaa      120

tgcaagttcc ccgtagagaa gcagctcgat ttggccgctt tgatagtgta ctgggaaatg      180

gaaggaaaag acatcattca attcgtccac ggtgaagagg atcaaaaagc gcaacatagc      240

tcctatagac aacgcgcacg cttgcttaaa gaccagctga gtcttggtaa cgcggcgctg      300

cagattaccg acgtaaaact tcaagacgcg ggagtttatc gctgcatgat ttcctacggg      360

ggtggcgcag actataaaag gatcactgta aaggtaaacg ccggtggagg tggctctgga      420

ggtggtggaa gcggtggcgg tggtagctgg ccacccccag gaaccgggga cgtcgtcgtg      480

caggcgccca cccaggtgtc cggcttcttg ggcgactccg tgacgctgcc ctgctaccta      540

caggtgccca acatggaggt gacgcatgtg tcacagctga cttgggcgcg gcatggtgaa      600

tctggcagca tggccgtctt ccaccaaacg cagggcccct ggtatgcgga gtccaaacgg      660

ctggaattcg tggcagccag actgggcgcg gagctgcgga atgcctcgct gagggtgttc      720

gggttgcgcg cagaggatga aggcaactac acctgccagt tcgtcacgtt cccgcagcgc      780

agcaggagcg tggatatctg gctccgagtg cttggaggtg gtggatcagg tggaggaggt      840

tccggaggag gtggatctaa agcgatgcac gtcgcccagc ctgctgtcgt attcgccagc      900

tcacacggca tcgcaagttt cgtatgcgaa tatgcctctc catggaaagc gaccgaggtc      960

agagttactg tactgagaca agctgattca caagtgactg aggtctgcgc tgctacttat     1020

atgacgggga acgagctgac tttccttgat gactcaatct gtaccggcac cagcagtggg     1080

aaccaagtaa atcttactat tcaaggactg agggcaatgg acacgggact ttacatttgt     1140

aaggtcgagc agatgtaccc gccaccttac ctcctcggaa tcggtaatgg tacgcaaatt     1200

tatgttatag atcctgaacc gtgccccgat tccgacggat ccggtggagg agggtcagag     1260

cccaaaagct ccgacaagac tcacacatgc cccccttgtc cagcgcctga agctgagggt     1320

gcgccctctg tcttcctttt cccccctaag ccgaaagata ccctgatgat ctcccgcact     1380

cccgaagtca catgtgttgt tgtcgacgta tctcatgaag atcctgaggt gaaattcaac     1440

tggtatgtag acggggtcga agttcataat gctaagacta agccacgaga agagcaatac     1500

aactcaacgt atcgggtggt gagcgttctg acggttctgc accaagattg gcttaatgga     1560

aaagagtata agtgcaaggt gtccaacaag gctcttccgg cacccatcga aaagacgatt     1620

tccaaagcga aaggccaacc tagggaaccg caagtttaca ctttgccccc gtcaagagac     1680

gaacttacca agaatcaagt ttccctgacg tgccttgtga agggcttcta ccctagcgat     1740

atagcagttg agtgggaatc taacggccag cccgaaaata attataagac tactccgccc     1800

gtgctggaca gtgatggttc atttttcctg tattcaaaac tcactgtgga caaatctaga     1860

tggcagcagg gtaatgtgtt ctcttgttca gttatgcacg aggcattgca caatcactat     1920

acgcaaaaaa gtttgtctct ctctccgggg                                      1950


<210>  3664
<211>  631
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - CD155 665 - CTLA4 3037 - Fc

<400>  3664

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro 
    130                 135                 140                 


Thr Gln Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr 
145                 150                 155                 160 


Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp 
                165                 170                 175     


Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln 
            180                 185                 190         


Gly Pro Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg 
        195                 200                 205             


Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Val Phe Gly Leu Arg 
    210                 215                 220                 


Ala Glu Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln 
225                 230                 235                 240 


Arg Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val 
            260                 265                 270         


Ala Gln Pro Ala Val Val Phe Ala Ser Ser His Gly Ile Ala Ser Phe 
        275                 280                 285             


Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg Val Thr 
    290                 295                 300                 


Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr 
305                 310                 315                 320 


Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr 
                325                 330                 335     


Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg 
            340                 345                 350         


Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met Tyr Pro 
        355                 360                 365             


Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile 
    370                 375                 380                 


Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                405                 410                 415     


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            420                 425                 430         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        435                 440                 445             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    450                 455                 460                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
465                 470                 475                 480 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                485                 490                 495     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            500                 505                 510         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        515                 520                 525             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    530                 535                 540                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
545                 550                 555                 560 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                565                 570                 575     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            580                 585                 590         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        595                 600                 605             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    610                 615                 620                 


Ser Leu Ser Leu Ser Pro Gly 
625                 630     


<210>  3665
<211>  1554
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CTLA4 3037 - PD-L1 303 - Fc

<400>  3665
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctaaa       60

gcgatgcacg tcgcccagcc tgccgtcgta ctcgctagct cacgcggcat cgctagtttc      120

gtatgcgaat atgcctctcc atggaaagcg accgaggtca gagttactgt actgagacaa      180

gctgattcac aagtgactga ggtctgcgct gctacttata tgatggggag cgagctgact      240

ttccctgatg actcaatctg taccggcacc agcagtggga accaagtaaa tcttactatt      300

cgaggactga gggcaatgga cacgggactt tacatttgta aggtcgagca gatgtacccg      360

ccaccttacc tcctcggaat cggtaatggt acgcaaattt atgttataga tcctgaaccg      420

tgccccgatt ccgacggatc cggagggtct gggggaggcg gttctggggg tggaggctca      480

tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt      540

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      600

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      660

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      720

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      780

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggcgg aggtggttcc      840

ggatccggtg gaggaggctc cgagcccaaa agctccgaca agactcacac atgcccccct      900

tgtccagcgc ctgaagctga gggtgcgccc tctgtcttcc ttttcccccc taagccgaaa      960

gataccctga tgatctcccg cactcccgaa gtcacatgtg ttgttgtcga cgtatctcat     1020

gaagatcctg aggtgaaatt caactggtat gtagacgggg tcgaagttca taatgctaag     1080

actaagccac gagaagagca atacaactca acgtatcggg tggtgagcgt tctgacggtt     1140

ctgcaccaag attggcttaa tggaaaagag tataagtgca aggtgtccaa caaggctctt     1200

ccggcaccca tcgaaaagac gatttccaaa gcgaaaggcc aacctaggga accgcaagtt     1260

tacactttgc ccccgtcaag agacgaactt accaagaatc aagtttccct gacgtgcctt     1320

gtgaagggct tctaccctag cgatatagca gttgagtggg aatctaacgg ccagcccgaa     1380

aataattata agactactcc gcccgtgctg gacagtgatg gttcattttt cctgtattca     1440

aaactcactg tggacaaatc tagatggcag cagggtaatg tgttctcttg ttcagttatg     1500

cacgaggcat tgcacaatca ctatacgcaa aaaagtttgt ctctctctcc gggg           1554


<210>  3666
<211>  499
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CTLA4 3037 - PD-L1 303 - Fc

<400>  3666

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val 
    130                 135                 140                 


Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr 
145                 150                 155                 160 


Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu 
                165                 170                 175     


Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His 
            180                 185                 190         


Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala 
        195                 200                 205             


Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile 
    210                 215                 220                 


Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser 
225                 230                 235                 240 


Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
        275                 280                 285             


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  3667
<211>  1554
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - CTLA4 3037 - Fc

<400>  3667
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctttt       60

accgtaacgg tccctaagga tttgtacgtg gttgagtacg ggagcaatat gacgattgaa      120

tgcaagttcc ccgtagagaa gcagctcgat ttggccgctt tgatagtgta ctgggaaatg      180

gaaggaaaag acatcattca attcgtccac ggtgaagagg atcaaaaagc gcaacatagc      240

tcctatagac aacgcgcacg cttgcttaaa gaccagctga gtcttggtaa cgcggcgctg      300

cagattaccg acgtaaaact tcaagacgcg ggagtttatc gctgcatgat ttcctacggg      360

ggtggcgcag actataaaag gatcactgta aaggtaaacg ccggatccgg agggtctggg      420

ggaggcggtt ctgggggtgg aggctcaaaa gcgatgcacg tcgcccagcc tgccgtcgta      480

ctcgctagct cacgcggcat cgctagtttc gtatgcgaat atgcctctcc atggaaagcg      540

accgaggtca gagttactgt actgagacaa gctgattcac aagtgactga ggtctgcgct      600

gctacttata tgatggggag cgagctgact ttccctgatg actcaatctg taccggcacc      660

agcagtggga accaagtaaa tcttactatt cgaggactga gggcaatgga cacgggactt      720

tacatttgta aggtcgagca gatgtacccg ccaccttacc tcctcggaat cggtaatggt      780

acgcaaattt atgttataga tcctgaaccg tgccccgatt ccgacggcgg aggtggttcc      840

ggatccggtg gaggaggctc cgagcccaaa agctccgaca agactcacac atgcccccct      900

tgtccagcgc ctgaagctga gggtgcgccc tctgtcttcc ttttcccccc taagccgaaa      960

gataccctga tgatctcccg cactcccgaa gtcacatgtg ttgttgtcga cgtatctcat     1020

gaagatcctg aggtgaaatt caactggtat gtagacgggg tcgaagttca taatgctaag     1080

actaagccac gagaagagca atacaactca acgtatcggg tggtgagcgt tctgacggtt     1140

ctgcaccaag attggcttaa tggaaaagag tataagtgca aggtgtccaa caaggctctt     1200

ccggcaccca tcgaaaagac gatttccaaa gcgaaaggcc aacctaggga accgcaagtt     1260

tacactttgc ccccgtcaag agacgaactt accaagaatc aagtttccct gacgtgcctt     1320

gtgaagggct tctaccctag cgatatagca gttgagtggg aatctaacgg ccagcccgaa     1380

aataattata agactactcc gcccgtgctg gacagtgatg gttcattttt cctgtattca     1440

aaactcactg tggacaaatc tagatggcag cagggtaatg tgttctcttg ttcagttatg     1500

cacgaggcat tgcacaatca ctatacgcaa aaaagtttgt ctctctctcc gggg           1554


<210>  3668
<211>  499
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - CTLA4 3037 - Fc

<400>  3668

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser 
    130                 135                 140                 


Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys 
145                 150                 155                 160 


Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val 
                165                 170                 175     


Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe 
            180                 185                 190         


Pro Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn 
        195                 200                 205             


Leu Thr Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys 
    210                 215                 220                 


Lys Val Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn 
225                 230                 235                 240 


Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
        275                 280                 285             


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  3669
<211>  1539
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CTLA4 3037 - Fc - PD-L1 303

<400>  3669
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctaaa       60

gcgatgcacg tcgcccagcc tgccgtcgta ctcgctagct cacgcggcat cgctagtttc      120

gtatgcgaat atgcctctcc atggaaagcg accgaggtca gagttactgt actgagacaa      180

gctgattcac aagtgactga ggtctgcgct gctacttata tgatggggag cgagctgact      240

ttccctgatg actcaatctg taccggcacc agcagtggga accaagtaaa tcttactatt      300

cgaggactga gggcaatgga cacgggactt tacatttgta aggtcgagca gatgtacccg      360

ccaccttacc tcctcggaat cggtaatggt acgcaaattt atgttataga tcctgaaccg      420

tgccccgatt ccgacgggtc tgggggaggc ggttctgagc ccaaaagctc cgacaagact      480

cacacatgcc ccccttgtcc agcgcccgaa gctgagggtg cgccctctgt cttccttttc      540

ccccctaagc cgaaagatac cctgatgatc tcccgcactc ccgaagtcac atgtgttgtt      600

gtcgacgtat ctcatgaaga tcctgaggtg aaattcaact ggtatgtaga cggggtcgaa      660

gttcataatg ctaagactaa gccacgagaa gagcaataca actcaacgta tcgggtggtg      720

agcgttctga cggttctgca ccaagattgg cttaatggaa aagagtataa gtgcaaggtg      780

tccaacaagg ctcttccggc acccatcgaa aagacgattt ccaaagcgaa aggccaacct      840

agggaaccgc aagtttacac tttgcccccg tcaagagacg aacttaccaa gaatcaagtt      900

tccctgacgt gccttgtgaa gggcttctac cctagcgata tagcagttga gtgggaatct      960

aacggccagc ccgaaaataa ttataagact actccgcccg tgctggacag tgatggttca     1020

tttttcctgt attcaaaact cactgtggac aaatctagat ggcagcaggg taatgtgttc     1080

tcttgttcag ttatgcacga ggcattgcac aatcactata cgcaaaaaag tttgtctctc     1140

tctccggggg gtggaggtgg ctctggaggt ggtggaagcg gtggcggtgg tagctttacc     1200

gtaacggtcc ctaaggattt gtacgtggtt gagtacggga gcaatatgac gattgaatgc     1260

aagttccccg tagagaagca gctcgatttg gccgctttga tagtgtactg ggaaatggaa     1320

ggaaaagaca tcattcaatt cgtccacggt gaagaggatc aaaaagcgca acatagctcc     1380

tatagacaac gcgcacgctt gcttaaagac cagctgagtc ttggtaacgc ggcgctgcag     1440

attaccgacg taaaacttca agacgcggga gtttatcgct gcatgatttc ctacgggggt     1500

ggcgcagact ataaaaggat cactgtaaag gtaaacgcc                            1539


<210>  3670
<211>  494
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CTLA4 3037 - Fc - PD-L1 303

<400>  3670

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val 
    370                 375                 380                 


Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu 
385                 390                 395                 400 


Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val 
                405                 410                 415     


Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu 
            420                 425                 430         


Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu 
        435                 440                 445             


Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp 
    450                 455                 460                 


Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly 
465                 470                 475                 480 


Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala 
                485                 490                 


<210>  3671
<211>  1542
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CTLA4 3037 - Fc - PD-L1 303

<400>  3671
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctaaa       60

gcgatgcacg tcgcccagcc tgccgtcgta ctcgctagct cacgcggcat cgctagtttc      120

gtatgcgaat atgcctctcc atggaaagcg accgaggtca gagttactgt actgagacaa      180

gctgattcac aagtgactga ggtctgcgct gctacttata tgatggggag cgagctgact      240

ttccctgatg actcaatctg taccggcacc agcagtggga accaagtaaa tcttactatt      300

cgaggactga gggcaatgga cacgggactt tacatttgta aggtcgagca gatgtacccg      360

ccaccttacc tcctcggaat cggtaatggt acgcaaattt atgttataga tcctgaaccg      420

tgccccgatt ccgacgggtc tgggggaggc ggttctgagc ccaaaagctc cgacaagact      480

cacacatgcc ccccttgtcc agcgcccgaa gctgagggtg cgccctctgt cttccttttc      540

ccccctaagc cgaaagatac cctgatgatc tcccgcactc ccgaagtcac atgtgttgtt      600

gtcgacgtat ctcatgaaga tcctgaggtg aaattcaact ggtatgtaga cggggtcgaa      660

gttcataatg ctaagactaa gccacgagaa gagcaataca actcaacgta tcgggtggtg      720

agcgttctga cggttctgca ccaagattgg cttaatggaa aagagtataa gtgcaaggtg      780

tccaacaagg ctcttccggc acccatcgaa aagacgattt ccaaagcgaa aggccaacct      840

agggaaccgc aagtttacac tttgcccccg tcaagagacg aacttaccaa gaatcaagtt      900

tccctgacgt gccttgtgaa gggcttctac cctagcgata tagcagttga gtgggaatct      960

aacggccagc ccgaaaataa ttataagact actccgcccg tgctggacag tgatggttca     1020

tttttcctgt attcaaaact cactgtggac aaatctagat ggcagcaggg taatgtgttc     1080

tcttgttcag ttatgcacga ggcattgcac aatcactata cgcaaaaaag tttgtctctc     1140

tctccggggg gtggaggtgg ctctggaggt ggtggaagcg gtggcggtgg tagcgcattt     1200

accgtaacgg tccctaagga tttgtacgtg gttgagtacg ggagcaatat gacgattgaa     1260

tgcaagttcc ccgtagagaa gcagctcgat ttggccgctt tgatagtgta ctgggaaatg     1320

gaaggaaaag acatcattca attcgtccac ggtgaagagg atcaaaaagc gcaacatagc     1380

tcctatagac aacgcgcacg cttgcttaaa gaccagctga gtcttggtaa cgcggcgctg     1440

cagattaccg acgtaaaact tcaagacgcg ggagtttatc gctgcatgat ttcctacggg     1500

ggtggcgcag actataaaag gatcactgta aaggtaaacg cc                        1542


<210>  3672
<211>  495
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CTLA4 3037 - Fc - PD-L1 303

<400>  3672

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Thr Val Thr 
    370                 375                 380                 


Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile 
385                 390                 395                 400 


Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile 
                405                 410                 415     


Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly 
            420                 425                 430         


Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg 
        435                 440                 445             


Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr 
    450                 455                 460                 


Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr 
465                 470                 475                 480 


Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala 
                485                 490                 495 


<210>  3673
<211>  1554
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CTLA4 3060 - PD-L1 303 - Fc

<400>  3673
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctaaa       60

gcgatgcacg tcgcccagcc tgctgtcgta ttcgccagct cacacggcat cgcaagtttc      120

gtatgcgaat atgcctctcc atggaaagcg accgaggtca gagttactgt actgagacaa      180

gctgattcac aagtgactga ggtctgcgct gctacttata tgacggggaa cgagctgact      240

ttccttgatg actcaatctg taccggcacc agcagtggga accaagtaaa tcttactatt      300

caaggactga gggcaatgga cacgggactt tacatttgta aggtcgagca gatgtacccg      360

ccaccttacc tcctcggaat cggtaatggt acgcaaattt atgttataga tcctgaaccg      420

tgccccgatt ccgacggatc cggagggtct gggggaggcg gttctggggg tggaggctca      480

tttaccgtaa cggtccctaa ggatttgtac gtggttgagt acgggagcaa tatgacgatt      540

gaatgcaagt tccccgtaga gaagcagctc gatttggccg ctttgatagt gtactgggaa      600

atggaaggaa aagacatcat tcaattcgtc cacggtgaag aggatcaaaa agcgcaacat      660

agctcctata gacaacgcgc acgcttgctt aaagaccagc tgagtcttgg taacgcggcg      720

ctgcagatta ccgacgtaaa acttcaagac gcgggagttt atcgctgcat gatttcctac      780

gggggtggcg cagactataa aaggatcact gtaaaggtaa acgccggtgg aggtgggtca      840

ggatccggtg gaggagggtc agagcccaaa agctccgaca agactcacac atgcccccct      900

tgtccagcgc ctgaagctga gggtgcgccc tctgtcttcc ttttcccccc taagccgaaa      960

gataccctga tgatctcccg cactcccgaa gtcacatgtg ttgttgtcga cgtatctcat     1020

gaagatcctg aggtgaaatt caactggtat gtagacgggg tcgaagttca taatgctaag     1080

actaagccac gagaagagca atacaactca acgtatcggg tggtgagcgt tctgacggtt     1140

ctgcaccaag attggcttaa tggaaaagag tataagtgca aggtgtccaa caaggctctt     1200

ccggcaccca tcgaaaagac gatttccaaa gcgaaaggcc aacctaggga accgcaagtt     1260

tacactttgc ccccgtcaag agacgaactt accaagaatc aagtttccct gacgtgcctt     1320

gtgaagggct tctaccctag cgatatagca gttgagtggg aatctaacgg ccagcccgaa     1380

aataattata agactactcc gcccgtgctg gacagtgatg gttcattttt cctgtattca     1440

aaactcactg tggacaaatc tagatggcag cagggtaatg tgttctcttg ttcagttatg     1500

cacgaggcat tgcacaatca ctatacgcaa aaaagtttgt ctctctctcc gggg           1554


<210>  3674
<211>  499
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CTLA4 3060 - PD-L1 303 - Fc

<400>  3674

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val 
    130                 135                 140                 


Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr 
145                 150                 155                 160 


Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu 
                165                 170                 175     


Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His 
            180                 185                 190         


Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala 
        195                 200                 205             


Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile 
    210                 215                 220                 


Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser 
225                 230                 235                 240 


Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
        275                 280                 285             


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  3675
<211>  1554
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - CTLA4 3060 - Fc

<400>  3675
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctttt       60

accgtaacgg tccctaagga tttgtacgtg gttgagtacg ggagcaatat gacgattgaa      120

tgcaagttcc ccgtagagaa gcagctcgat ttggccgctt tgatagtgta ctgggaaatg      180

gaaggaaaag acatcattca attcgtccac ggtgaagagg atcaaaaagc gcaacatagc      240

tcctatagac aacgcgcacg cttgcttaaa gaccagctga gtcttggtaa cgcggcgctg      300

cagattaccg acgtaaaact tcaagacgcg ggagtttatc gctgcatgat ttcctacggg      360

ggtggcgcag actataaaag gatcactgta aaggtaaacg ccggatccgg agggtctggg      420

ggaggcggtt ctgggggtgg aggctcaaaa gcgatgcacg tcgcccagcc tgctgtcgta      480

ttcgccagct cacacggcat cgcaagtttc gtatgcgaat atgcctctcc atggaaagcg      540

accgaggtca gagttactgt actgagacaa gctgattcac aagtgactga ggtctgcgct      600

gctacttata tgacggggaa cgagctgact ttccttgatg actcaatctg taccggcacc      660

agcagtggga accaagtaaa tcttactatt caaggactga gggcaatgga cacgggactt      720

tacatttgta aggtcgagca gatgtacccg ccaccttacc tcctcggaat cggtaatggt      780

acgcaaattt atgttataga tcctgaaccg tgccccgatt ccgacggtgg aggtgggtca      840

ggatccggtg gaggagggtc agagcccaaa agctccgaca agactcacac atgcccccct      900

tgtccagcgc ctgaagctga gggtgcgccc tctgtcttcc ttttcccccc taagccgaaa      960

gataccctga tgatctcccg cactcccgaa gtcacatgtg ttgttgtcga cgtatctcat     1020

gaagatcctg aggtgaaatt caactggtat gtagacgggg tcgaagttca taatgctaag     1080

actaagccac gagaagagca atacaactca acgtatcggg tggtgagcgt tctgacggtt     1140

ctgcaccaag attggcttaa tggaaaagag tataagtgca aggtgtccaa caaggctctt     1200

ccggcaccca tcgaaaagac gatttccaaa gcgaaaggcc aacctaggga accgcaagtt     1260

tacactttgc ccccgtcaag agacgaactt accaagaatc aagtttccct gacgtgcctt     1320

gtgaagggct tctaccctag cgatatagca gttgagtggg aatctaacgg ccagcccgaa     1380

aataattata agactactcc gcccgtgctg gacagtgatg gttcattttt cctgtattca     1440

aaactcactg tggacaaatc tagatggcag cagggtaatg tgttctcttg ttcagttatg     1500

cacgaggcat tgcacaatca ctatacgcaa aaaagtttgt ctctctctcc gggg           1554


<210>  3676
<211>  499
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - CTLA4 3060 - Fc

<400>  3676

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser 
    130                 135                 140                 


Ser His Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys 
145                 150                 155                 160 


Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val 
                165                 170                 175     


Thr Glu Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe 
            180                 185                 190         


Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn 
        195                 200                 205             


Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys 
    210                 215                 220                 


Lys Val Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn 
225                 230                 235                 240 


Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
            260                 265                 270         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
        275                 280                 285             


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly 
            


<210>  3677
<211>  1020
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - ICOSL 2264 - ZZ12.6

<400>  3677
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctttt       60

actgttacgg tacccaaaga cctgtacgta gtggagtacg ggtccaatat gaccatagaa      120

tgcaaattcc ccgtcgagaa gcaattggat ctcgccgctc tgatcgtcta ctgggagatg      180

gagggcaaag atatcattca attcgtacac ggggaagaag atcagaaagc tcaacacagc      240

tcttacaggc aacgggcgag actgctcaag gaccaattga gtcttggaaa cgctgcactt      300

cagatcaccg acgtgaagtt gcaggatgca ggcgtgtatc ggtgcatgat aagctatgga      360

ggaggggcag attataaaag gattacggtg aaggtaaacg caggtggcgg aggttctggc      420

ggaggtggaa gtggcggagg tggctctgat actcaggaga aggaagtcag agcgatggta      480

ggcagcgacg tggagctcag ctgcgcttgc cctgaaggaa gccgttttga tttaaatgat      540

gtttacgtat attggcaaac cagtgagtcg aaaaccgtgg tgacctacca catcccacag      600

cacagctcct tggaatatgt ggacagccgc taccggaacc gagccctgat gtcaccggcc      660

ggcatgctgc ggggcgactt ctccctgcgc ttgttcaacg tcacccccca ggacgagcag      720

aagtttcact gcctggtgtt gagcagatcc ctgggattcc aggaggtttt gagcgttgag      780

gttacactgc atgtggcagc aaacttcagc gtgggtggcg gaggttctgg cggaggtgga      840

agtggcggag gtggctctga cgtccaggcg atctcctcca ccatccagga ccttcaggac      900

caggtcgact ccctggcgga ggtggtgctg cagaatcgcc gcggccttga ccttcttacg      960

agaagcggcg gtggatcaga ctataaagat gacgacgaca aacaccatca tcaccatcac     1020


<210>  3678
<211>  321
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - ICOSL 2264 - ZZ12.6

<400>  3678

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
    130                 135                 140                 


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
145                 150                 155                 160 


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
                165                 170                 175     


Tyr His Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr 
            180                 185                 190         


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
        195                 200                 205             


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
    210                 215                 220                 


Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
225                 230                 235                 240 


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Ala Ile 
            260                 265                 270         


Ser Ser Thr Ile Gln Asp Leu Gln Asp Gln Val Asp Ser Leu Ala Glu 
        275                 280                 285             


Val Val Leu Gln Asn Arg Arg Gly Leu Asp Leu Leu Thr Arg Ser Gly 
    290                 295                 300                 


Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His 
305                 310                 315                 320 


His 
    


<210>  3679
<211>  1443
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD58 3650 - PD-L1 303 - Fc

<400>  3679
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgcttcc       60

caacaaatat atggtgttgt gtatgggaat gtaactttcc atgtaccaag caatgtgcct      120

ttaaaagagg tcctatggaa aaaacaaaag gataaagttg cagaactgga aaattctgaa      180

ttcagagctt tctcatcttt taaaaatagg gtttatttag acactgtgtc aggtagcctc      240

actatctaca acttaacatc atcagatgaa gatgagtatg aaatggaatc gccaaatatt      300

actgatacca tgaagttctt tctttatgtg cttgagtctg gaggtggtgg atcaggtgga      360

ggaggttccg gaggaggtgg atcttttacc gtaacggtcc ctaaggattt gtacgtggtt      420

gagtacggga gcaatatgac gattgaatgc aagttccccg tagagaagca gctcgatttg      480

gccgctttga tagtgtactg ggaaatggaa ggaaaagaca tcattcaatt cgtccacggt      540

gaagaggatc aaaaagcgca acatagctcc tatagacaac gcgcacgctt gcttaaagac      600

cagctgagtc ttggtaacgc ggcgctgcag attaccgacg taaaacttca agacgcggga      660

gtttatcgct gcatgatttc ctacgggggt ggcgcagact ataaaaggat cactgtaaag      720

gtaaacgccg gatccggtgg aggagggtca gagcccaaaa gctccgacaa gactcacaca      780

tgcccccctt gtccagcgcc tgaagctgag ggtgcgccct ctgtcttcct tttcccccct      840

aagccgaaag ataccctgat gatctcccgc actcccgaag tcacatgtgt tgttgtcgac      900

gtatctcatg aagatcctga ggtgaaattc aactggtatg tagacggggt cgaagttcat      960

aatgctaaga ctaagccacg agaagagcaa tacaactcaa cgtatcgggt ggtgagcgtt     1020

ctgacggttc tgcaccaaga ttggcttaat ggaaaagagt ataagtgcaa ggtgtccaac     1080

aaggctcttc cggcacccat cgaaaagacg atttccaaag cgaaaggcca acctagggaa     1140

ccgcaagttt acactttgcc cccgtcaaga gacgaactta ccaagaatca agtttccctg     1200

acgtgccttg tgaagggctt ctaccctagc gatatagcag ttgagtggga atctaacggc     1260

cagcccgaaa ataattataa gactactccg cccgtgctgg acagtgatgg ttcatttttc     1320

ctgtattcaa aactcactgt ggacaaatct agatggcagc agggtaatgt gttctcttgt     1380

tcagttatgc acgaggcatt gcacaatcac tatacgcaaa aaagtttgtc tctctctccg     1440

ggg                                                                   1443


<210>  3680
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD58 3650 - PD-L1 303 - Fc

<400>  3680

Ser Gln Gln Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His Val 
1               5                   10                  15      


Pro Ser Asn Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys Asp 
            20                  25                  30          


Lys Val Ala Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser Phe 
        35                  40                  45              


Lys Asn Arg Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr 
    50                  55                  60                  


Asn Leu Thr Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn 
65                  70                  75                  80  


Ile Thr Asp Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Gly Gly 
                85                  90                  95      


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val 
            100                 105                 110         


Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr 
        115                 120                 125             


Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu 
    130                 135                 140                 


Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His 
145                 150                 155                 160 


Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala 
                165                 170                 175     


Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile 
            180                 185                 190         


Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser 
        195                 200                 205             


Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460         


<210>  3681
<211>  1443
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - CD58 3650 - Fc

<400>  3681
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctttt       60

accgtaacgg tccctaagga tttgtacgtg gttgagtacg ggagcaatat gacgattgaa      120

tgcaagttcc ccgtagagaa gcagctcgat ttggccgctt tgatagtgta ctgggaaatg      180

gaaggaaaag acatcattca attcgtccac ggtgaagagg atcaaaaagc gcaacatagc      240

tcctatagac aacgcgcacg cttgcttaaa gaccagctga gtcttggtaa cgcggcgctg      300

cagattaccg acgtaaaact tcaagacgcg ggagtttatc gctgcatgat ttcctacggg      360

ggtggcgcag actataaaag gatcactgta aaggtaaacg ccggaggtgg tggatcaggt      420

ggaggaggtt ccggaggagg tggatcttcc caacaaatat atggtgttgt gtatgggaat      480

gtaactttcc atgtaccaag caatgtgcct ttaaaagagg tcctatggaa aaaacaaaag      540

gataaagttg cagaactgga aaattctgaa ttcagagctt tctcatcttt taaaaatagg      600

gtttatttag acactgtgtc aggtagcctc actatctaca acttaacatc atcagatgaa      660

gatgagtatg aaatggaatc gccaaatatt actgatacca tgaagttctt tctttatgtg      720

cttgagtctg gatccggtgg aggagggtca gagcccaaaa gctccgacaa gactcacaca      780

tgcccccctt gtccagcgcc tgaagctgag ggtgcgccct ctgtcttcct tttcccccct      840

aagccgaaag ataccctgat gatctcccgc actcccgaag tcacatgtgt tgttgtcgac      900

gtatctcatg aagatcctga ggtgaaattc aactggtatg tagacggggt cgaagttcat      960

aatgctaaga ctaagccacg agaagagcaa tacaactcaa cgtatcgggt ggtgagcgtt     1020

ctgacggttc tgcaccaaga ttggcttaat ggaaaagagt ataagtgcaa ggtgtccaac     1080

aaggctcttc cggcacccat cgaaaagacg atttccaaag cgaaaggcca acctagggaa     1140

ccgcaagttt acactttgcc cccgtcaaga gacgaactta ccaagaatca agtttccctg     1200

acgtgccttg tgaagggctt ctaccctagc gatatagcag ttgagtggga atctaacggc     1260

cagcccgaaa ataattataa gactactccg cccgtgctgg acagtgatgg ttcatttttc     1320

ctgtattcaa aactcactgt ggacaaatct agatggcagc agggtaatgt gttctcttgt     1380

tcagttatgc acgaggcatt gcacaatcac tatacgcaaa aaagtttgtc tctctctccg     1440

ggg                                                                   1443


<210>  3682
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - CD58 3650 - Fc

<400>  3682

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Ser Gln Gln Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe 
    130                 135                 140                 


His Val Pro Ser Asn Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln 
145                 150                 155                 160 


Lys Asp Lys Val Ala Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser 
                165                 170                 175     


Ser Phe Lys Asn Arg Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr 
            180                 185                 190         


Ile Tyr Asn Leu Thr Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser 
        195                 200                 205             


Pro Asn Ile Thr Asp Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460         


<210>  3683
<211>  1509
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - PD-L1 303 - CD58 3650 - CD58 3650

<400>  3683
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgctttt       60

accgtaacgg tccctaagga tttgtacgtg gttgagtacg ggagcaatat gacgattgaa      120

tgcaagttcc ccgtagagaa gcagctcgat ttggccgctt tgatagtgta ctgggaaatg      180

gaaggaaaag acatcattca attcgtccac ggtgaagagg atcaaaaagc gcaacatagc      240

tcctatagac aacgcgcacg cttgcttaaa gaccagctga gtcttggtaa cgcggcgctg      300

cagattaccg acgtaaaact tcaagacgcg ggagtttatc gctgcatgat ttcctacggg      360

ggtggcgcag actataaaag gatcactgta aaggtaaacg ccggaggtgg tggatcaggt      420

ggaggaggtt ccggaggagg tggatctttc acggttacag ttcctaagga cttgtatgta      480

gtagagtacg gctccaacat gaccatagaa tgtaagtttc ccgtagaaaa gcagttggac      540

ttggctgcgt tgatagtata ttgggaaatg gaaggcaaag atatcatcca attcgttcac      600

ggtgaagagg accaaaaggc ccagcattca agttatcgac agagggctag attgctcaaa      660

gatcagctct cccttggaaa cgcggcgttg caaataactg acgttaaact ccaagatgcc      720

ggggtctatc gatgtatgat ctcttacggt ggcggagcgg attataaacg gataaccgtc      780

aaggtgaacg ccggtggagg tggctctgga ggtggtggaa gcggtggcgg tggtagctcc      840

caacaaatat atggtgttgt gtatgggaat gtaactttcc atgtaccaag caatgtgcct      900

ttaaaagagg tcctatggaa aaaacaaaag gataaagttg cagaactgga aaattctgaa      960

ttcagagctt tctcatcttt taaaaatagg gtttatttag acactgtgtc aggtagcctc     1020

actatctaca acttaacatc atcagatgaa gatgagtatg aaatggaatc gccaaatatt     1080

actgatacca tgaagttctt tctttatgtg cttgagtctg gatccggagg gtctggggga     1140

ggcggttctg ggggtggagg ctcaagccag cagatatatg gagtagtata tggaaacgtc     1200

acttttcatg ttcctagtaa cgtacctctg aaagaagtac tttggaagaa gcagaaggat     1260

aaagtggctg aattggagaa tagcgaattt agagcttttt cctcattcaa aaatcgggtc     1320

tatcttgata cggtctcagg ctcacttact atttacaatc ttacttctag cgacgaggac     1380

gagtacgaga tggaatctcc gaatatcaca gacactatga aatttttttt gtacgtcctt     1440

gagagcggat ccggtggagg agggtcagac tataaagatg acgacgacaa acaccatcat     1500

caccatcac                                                             1509


<210>  3684
<211>  484
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PD-L1 303 - PD-L1 303 - CD58 3650 - CD58 3650

<400>  3684

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
    130                 135                 140                 


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
145                 150                 155                 160 


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile 
                165                 170                 175     


Ile Gln Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser 
            180                 185                 190         


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
        195                 200                 205             


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
    210                 215                 220                 


Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr 
225                 230                 235                 240 


Val Lys Val Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ser Gln Gln Ile Tyr Gly Val Val Tyr Gly Asn Val 
            260                 265                 270         


Thr Phe His Val Pro Ser Asn Val Pro Leu Lys Glu Val Leu Trp Lys 
        275                 280                 285             


Lys Gln Lys Asp Lys Val Ala Glu Leu Glu Asn Ser Glu Phe Arg Ala 
    290                 295                 300                 


Phe Ser Ser Phe Lys Asn Arg Val Tyr Leu Asp Thr Val Ser Gly Ser 
305                 310                 315                 320 


Leu Thr Ile Tyr Asn Leu Thr Ser Ser Asp Glu Asp Glu Tyr Glu Met 
                325                 330                 335     


Glu Ser Pro Asn Ile Thr Asp Thr Met Lys Phe Phe Leu Tyr Val Leu 
            340                 345                 350         


Glu Ser Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Ser Gln Gln Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His 
    370                 375                 380                 


Val Pro Ser Asn Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys 
385                 390                 395                 400 


Asp Lys Val Ala Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser 
                405                 410                 415     


Phe Lys Asn Arg Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile 
            420                 425                 430         


Tyr Asn Leu Thr Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro 
        435                 440                 445             


Asn Ile Thr Asp Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys His His 
465                 470                 475                 480 


His His His His 
                


<210>  3685
<211>  1509
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD58 3650 - CD58 3650 - PD-L1 303 - PD-L1 303

<400>  3685
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgcttcc       60

caacaaatat atggtgttgt gtatgggaat gtaactttcc atgtaccaag caatgtgcct      120

ttaaaagagg tcctatggaa aaaacaaaag gataaagttg cagaactgga aaattctgaa      180

ttcagagctt tctcatcttt taaaaatagg gtttatttag acactgtgtc aggtagcctc      240

actatctaca acttaacatc atcagatgaa gatgagtatg aaatggaatc gccaaatatt      300

actgatacca tgaagttctt tctttatgtg cttgagtctg gaggtggtgg atcaggtgga      360

ggaggttccg gaggaggtgg atctagccag cagatatatg gagtagtata tggaaacgtc      420

acttttcatg ttcctagtaa cgtacctctg aaagaagtac tttggaagaa gcagaaggat      480

aaagtggctg aattggagaa tagcgaattt agagcttttt cctcattcaa aaatcgggtc      540

tatcttgata cggtctcagg ctcacttact atttacaatc ttacttctag cgacgaggac      600

gagtacgaga tggaatctcc gaatatcaca gacactatga aatttttttt gtacgtcctt      660

gagagcggtg gaggtggctc tggaggtggt ggaagcggtg gcggtggtag ctttaccgta      720

acggtcccta aggatttgta cgtggttgag tacgggagca atatgacgat tgaatgcaag      780

ttccccgtag agaagcagct cgatttggcc gctttgatag tgtactggga aatggaagga      840

aaagacatca ttcaattcgt ccacggtgaa gaggatcaaa aagcgcaaca tagctcctat      900

agacaacgcg cacgcttgct taaagaccag ctgagtcttg gtaacgcggc gctgcagatt      960

accgacgtaa aacttcaaga cgcgggagtt tatcgctgca tgatttccta cgggggtggc     1020

gcagactata aaaggatcac tgtaaaggta aacgccggat ccggagggtc tgggggaggc     1080

ggttctgggg gtggaggctc attcacggtt acagttccta aggacttgta tgtagtagag     1140

tacggctcca acatgaccat agaatgtaag tttcccgtag aaaagcagtt ggacttggct     1200

gcgttgatag tatattggga aatggaaggc aaagatatca tccaattcgt tcacggtgaa     1260

gaggaccaaa aggcccagca ttcaagttat cgacagaggg ctagattgct caaagatcag     1320

ctctcccttg gaaacgcggc gttgcaaata actgacgtta aactccaaga tgccggggtc     1380

tatcgatgta tgatctctta cggtggcgga gcggattata aacggataac cgtcaaggtg     1440

aacgccggat ccggtggagg agggtcagac tataaagatg acgacgacaa acaccatcat     1500

caccatcac                                                             1509


<210>  3686
<211>  484
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD58 3650 - CD58 3650 - PD-L1 303 - PD-L1 303

<400>  3686

Ser Gln Gln Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His Val 
1               5                   10                  15      


Pro Ser Asn Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys Asp 
            20                  25                  30          


Lys Val Ala Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser Phe 
        35                  40                  45              


Lys Asn Arg Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr 
    50                  55                  60                  


Asn Leu Thr Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn 
65                  70                  75                  80  


Ile Thr Asp Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Gly Gly 
                85                  90                  95      


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gln Gln 
            100                 105                 110         


Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His Val Pro Ser Asn 
        115                 120                 125             


Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys Asp Lys Val Ala 
    130                 135                 140                 


Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser Phe Lys Asn Arg 
145                 150                 155                 160 


Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr Asn Leu Thr 
                165                 170                 175     


Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn Ile Thr Asp 
            180                 185                 190         


Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr Val Pro 
    210                 215                 220                 


Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys 
225                 230                 235                 240 


Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr 
                245                 250                 255     


Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu Glu 
            260                 265                 270         


Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu 
        275                 280                 285             


Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val 
    290                 295                 300                 


Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly 
305                 310                 315                 320 


Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Gly Ser Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val Thr 
            340                 345                 350         


Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile 
        355                 360                 365             


Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile 
    370                 375                 380                 


Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly 
385                 390                 395                 400 


Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg 
                405                 410                 415     


Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr 
            420                 425                 430         


Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr 
        435                 440                 445             


Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys His His 
465                 470                 475                 480 


His His His His 
                


<210>  3687
<211>  1509
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CD58 3650 - PD-L1 303 - PD-L1 303 - CD58 3650

<400>  3687
atggggtcaa ccgccatcct cgccctcctc ctggctgttc tccaaggagt cagcgcttcc       60

caacaaatat atggtgttgt gtatgggaat gtaactttcc atgtaccaag caatgtgcct      120

ttaaaagagg tcctatggaa aaaacaaaag gataaagttg cagaactgga aaattctgaa      180

ttcagagctt tctcatcttt taaaaatagg gtttatttag acactgtgtc aggtagcctc      240

actatctaca acttaacatc atcagatgaa gatgagtatg aaatggaatc gccaaatatt      300

actgatacca tgaagttctt tctttatgtg cttgagtctg gaggtggtgg atcaggtgga      360

ggaggttccg gaggaggtgg atcttttacc gtaacggtcc ctaaggattt gtacgtggtt      420

gagtacggga gcaatatgac gattgaatgc aagttccccg tagagaagca gctcgatttg      480

gccgctttga tagtgtactg ggaaatggaa ggaaaagaca tcattcaatt cgtccacggt      540

gaagaggatc aaaaagcgca acatagctcc tatagacaac gcgcacgctt gcttaaagac      600

cagctgagtc ttggtaacgc ggcgctgcag attaccgacg taaaacttca agacgcggga      660

gtttatcgct gcatgatttc ctacgggggt ggcgcagact ataaaaggat cactgtaaag      720

gtaaacgccg gtggaggtgg ctctggaggt ggtggaagcg gtggcggtgg tagcttcacg      780

gttacagttc ctaaggactt gtatgtagta gagtacggct ccaacatgac catagaatgt      840

aagtttcccg tagaaaagca gttggacttg gctgcgttga tagtatattg ggaaatggaa      900

ggcaaagata tcatccaatt cgttcacggt gaagaggacc aaaaggccca gcattcaagt      960

tatcgacaga gggctagatt gctcaaagat cagctctccc ttggaaacgc ggcgttgcaa     1020

ataactgacg ttaaactcca agatgccggg gtctatcgat gtatgatctc ttacggtggc     1080

ggagcggatt ataaacggat aaccgtcaag gtgaacgccg gatccggagg gtctggggga     1140

ggcggttctg ggggtggagg ctcaagccag cagatatatg gagtagtata tggaaacgtc     1200

acttttcatg ttcctagtaa cgtacctctg aaagaagtac tttggaagaa gcagaaggat     1260

aaagtggctg aattggagaa tagcgaattt agagcttttt cctcattcaa aaatcgggtc     1320

tatcttgata cggtctcagg ctcacttact atttacaatc ttacttctag cgacgaggac     1380

gagtacgaga tggaatctcc gaatatcaca gacactatga aatttttttt gtacgtcctt     1440

gagagcggat ccggtggagg agggtcagac tataaagatg acgacgacaa acaccatcat     1500

caccatcac                                                             1509


<210>  3688
<211>  484
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD58 3650 - PD-L1 303 - PD-L1 303 - CD58 3650

<400>  3688

Ser Gln Gln Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His Val 
1               5                   10                  15      


Pro Ser Asn Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys Asp 
            20                  25                  30          


Lys Val Ala Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser Phe 
        35                  40                  45              


Lys Asn Arg Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr 
    50                  55                  60                  


Asn Leu Thr Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn 
65                  70                  75                  80  


Ile Thr Asp Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Gly Gly 
                85                  90                  95      


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Thr Val 
            100                 105                 110         


Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr 
        115                 120                 125             


Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu 
    130                 135                 140                 


Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His 
145                 150                 155                 160 


Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala 
                165                 170                 175     


Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile 
            180                 185                 190         


Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser 
        195                 200                 205             


Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe 
225                 230                 235                 240 


Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn 
                245                 250                 255     


Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala 
            260                 265                 270         


Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe 
        275                 280                 285             


Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln 
    290                 295                 300                 


Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu 
305                 310                 315                 320 


Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met 
                325                 330                 335     


Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            340                 345                 350         


Asn Ala Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Ser Gln Gln Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His 
    370                 375                 380                 


Val Pro Ser Asn Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys 
385                 390                 395                 400 


Asp Lys Val Ala Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser 
                405                 410                 415     


Phe Lys Asn Arg Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile 
            420                 425                 430         


Tyr Asn Leu Thr Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro 
        435                 440                 445             


Asn Ile Thr Asp Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys His His 
465                 470                 475                 480 


His His His His 
                


