                         SEQUENCE LISTING

<110>  CELGENE CORPORATION
 
<120>  METHODS FOR SCREENING CEREBLON MODIFYING COMPOUNDS

<130>  14247-269-228

<140>  To Be Assigned
<141>  Herewith

<150>  62/617,112
<151>  2018-01-12

<150>  62/710,401
<151>  2018-02-16

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  1053
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequences of human SALL4A

<400>  1

Met Ser Arg Arg Lys Gln Ala Lys Pro Gln His Ile Asn Ser Glu Glu 
1               5                   10                  15      


Asp Gln Gly Glu Gln Gln Pro Gln Gln Gln Thr Pro Glu Phe Ala Asp 
            20                  25                  30          


Ala Ala Pro Ala Ala Pro Ala Ala Gly Glu Leu Gly Ala Pro Val Asn 
        35                  40                  45              


His Pro Gly Asn Asp Glu Val Ala Ser Glu Asp Glu Ala Thr Val Lys 
    50                  55                  60                  


Arg Leu Arg Arg Glu Glu Thr His Val Cys Glu Lys Cys Cys Ala Glu 
65                  70                  75                  80  


Phe Phe Ser Ile Ser Glu Phe Leu Glu His Lys Lys Asn Cys Thr Lys 
                85                  90                  95      


Asn Pro Pro Val Leu Ile Met Asn Asp Ser Glu Gly Pro Val Pro Ser 
            100                 105                 110         


Glu Asp Phe Ser Gly Ala Val Leu Ser His Gln Pro Thr Ser Pro Gly 
        115                 120                 125             


Ser Lys Asp Cys His Arg Glu Asn Gly Gly Ser Ser Glu Asp Met Lys 
    130                 135                 140                 


Glu Lys Pro Asp Ala Glu Ser Val Val Tyr Leu Lys Thr Glu Thr Ala 
145                 150                 155                 160 


Leu Pro Pro Thr Pro Gln Asp Ile Ser Tyr Leu Ala Lys Gly Lys Val 
                165                 170                 175     


Ala Asn Thr Asn Val Thr Leu Gln Ala Leu Arg Gly Thr Lys Val Ala 
            180                 185                 190         


Val Asn Gln Arg Ser Ala Asp Ala Leu Pro Ala Pro Val Pro Gly Ala 
        195                 200                 205             


Asn Ser Ile Pro Trp Val Leu Glu Gln Ile Leu Cys Leu Gln Gln Gln 
    210                 215                 220                 


Gln Leu Gln Gln Ile Gln Leu Thr Glu Gln Ile Arg Ile Gln Val Asn 
225                 230                 235                 240 


Met Trp Ala Ser His Ala Leu His Ser Ser Gly Ala Gly Ala Asp Thr 
                245                 250                 255     


Leu Lys Thr Leu Gly Ser His Met Ser Gln Gln Val Ser Ala Ala Val 
            260                 265                 270         


Ala Leu Leu Ser Gln Lys Ala Gly Ser Gln Gly Leu Ser Leu Asp Ala 
        275                 280                 285             


Leu Lys Gln Ala Lys Leu Pro His Ala Asn Ile Pro Ser Ala Thr Ser 
    290                 295                 300                 


Ser Leu Ser Pro Gly Leu Ala Pro Phe Thr Leu Lys Pro Asp Gly Thr 
305                 310                 315                 320 


Arg Val Leu Pro Asn Val Met Ser Arg Leu Pro Ser Ala Leu Leu Pro 
                325                 330                 335     


Gln Ala Pro Gly Ser Val Leu Phe Gln Ser Pro Phe Ser Thr Val Ala 
            340                 345                 350         


Leu Asp Thr Ser Lys Lys Gly Lys Gly Lys Pro Pro Asn Ile Ser Ala 
        355                 360                 365             


Val Asp Val Lys Pro Lys Asp Glu Ala Ala Leu Tyr Lys His Lys Cys 
    370                 375                 380                 


Lys Tyr Cys Ser Lys Val Phe Gly Thr Asp Ser Ser Leu Gln Ile His 
385                 390                 395                 400 


Leu Arg Ser His Thr Gly Glu Arg Pro Phe Val Cys Ser Val Cys Gly 
                405                 410                 415     


His Arg Phe Thr Thr Lys Gly Asn Leu Lys Val His Phe His Arg His 
            420                 425                 430         


Pro Gln Val Lys Ala Asn Pro Gln Leu Phe Ala Glu Phe Gln Asp Lys 
        435                 440                 445             


Val Ala Ala Gly Asn Gly Ile Pro Tyr Ala Leu Ser Val Pro Asp Pro 
    450                 455                 460                 


Ile Asp Glu Pro Ser Leu Ser Leu Asp Ser Lys Pro Val Leu Val Thr 
465                 470                 475                 480 


Thr Ser Val Gly Leu Pro Gln Asn Leu Ser Ser Gly Thr Asn Pro Lys 
                485                 490                 495     


Asp Leu Thr Gly Gly Ser Leu Pro Gly Asp Leu Gln Pro Gly Pro Ser 
            500                 505                 510         


Pro Glu Ser Glu Gly Gly Pro Thr Leu Pro Gly Val Gly Pro Asn Tyr 
        515                 520                 525             


Asn Ser Pro Arg Ala Gly Gly Phe Gln Gly Ser Gly Thr Pro Glu Pro 
    530                 535                 540                 


Gly Ser Glu Thr Leu Lys Leu Gln Gln Leu Val Glu Asn Ile Asp Lys 
545                 550                 555                 560 


Ala Thr Thr Asp Pro Asn Glu Cys Leu Ile Cys His Arg Val Leu Ser 
                565                 570                 575     


Cys Gln Ser Ser Leu Lys Met His Tyr Arg Thr His Thr Gly Glu Arg 
            580                 585                 590         


Pro Phe Gln Cys Lys Ile Cys Gly Arg Ala Phe Ser Thr Lys Gly Asn 
        595                 600                 605             


Leu Lys Thr His Leu Gly Val His Arg Thr Asn Thr Ser Ile Lys Thr 
    610                 615                 620                 


Gln His Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val Met 
625                 630                 635                 640 


Leu Gln Gln His Ile Arg Met His Met Gly Gly Gln Ile Pro Asn Thr 
                645                 650                 655     


Pro Leu Pro Glu Asn Pro Cys Asp Phe Thr Gly Ser Glu Pro Met Thr 
            660                 665                 670         


Val Gly Glu Asn Gly Ser Thr Gly Ala Ile Cys His Asp Asp Val Ile 
        675                 680                 685             


Glu Ser Ile Asp Val Glu Glu Val Ser Ser Gln Glu Ala Pro Ser Ser 
    690                 695                 700                 


Ser Ser Lys Val Pro Thr Pro Leu Pro Ser Ile His Ser Ala Ser Pro 
705                 710                 715                 720 


Thr Leu Gly Phe Ala Met Met Ala Ser Leu Asp Ala Pro Gly Lys Val 
                725                 730                 735     


Gly Pro Ala Pro Phe Asn Leu Gln Arg Gln Gly Ser Arg Glu Asn Gly 
            740                 745                 750         


Ser Val Glu Ser Asp Gly Leu Thr Asn Asp Ser Ser Ser Leu Met Gly 
        755                 760                 765             


Asp Gln Glu Tyr Gln Ser Arg Ser Pro Asp Ile Leu Glu Thr Thr Ser 
    770                 775                 780                 


Phe Gln Ala Leu Ser Pro Ala Asn Ser Gln Ala Glu Ser Ile Lys Ser 
785                 790                 795                 800 


Lys Ser Pro Asp Ala Gly Ser Lys Ala Glu Ser Ser Glu Asn Ser Arg 
                805                 810                 815     


Thr Glu Met Glu Gly Arg Ser Ser Leu Pro Ser Thr Phe Ile Arg Ala 
            820                 825                 830         


Pro Pro Thr Tyr Val Lys Val Glu Val Pro Gly Thr Phe Val Gly Pro 
        835                 840                 845             


Ser Thr Leu Ser Pro Gly Met Thr Pro Leu Leu Ala Ala Gln Pro Arg 
    850                 855                 860                 


Arg Gln Ala Lys Gln His Gly Cys Thr Arg Cys Gly Lys Asn Phe Ser 
865                 870                 875                 880 


Ser Ala Ser Ala Leu Gln Ile His Glu Arg Thr His Thr Gly Glu Lys 
                885                 890                 895     


Pro Phe Val Cys Asn Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn 
            900                 905                 910         


Leu Lys Val His Tyr Met Thr His Gly Ala Asn Asn Asn Ser Ala Arg 
        915                 920                 925             


Arg Gly Arg Lys Leu Ala Ile Glu Asn Thr Met Ala Leu Leu Gly Thr 
    930                 935                 940                 


Asp Gly Lys Arg Val Ser Glu Ile Phe Pro Lys Glu Ile Leu Ala Pro 
945                 950                 955                 960 


Ser Val Asn Val Asp Pro Val Val Trp Asn Gln Tyr Thr Ser Met Leu 
                965                 970                 975     


Asn Gly Gly Leu Ala Val Lys Thr Asn Glu Ile Ser Val Ile Gln Ser 
            980                 985                 990         


Gly Gly Val Pro Thr Leu Pro Val  Ser Leu Gly Ala Thr  Ser Val Val 
        995                 1000                 1005             


Asn Asn  Ala Thr Val Ser Lys  Met Asp Gly Ser Gln  Ser Gly Ile 
    1010                 1015                 1020             


Ser Ala  Asp Val Glu Lys Pro  Ser Ala Thr Asp Gly  Val Pro Lys 
    1025                 1030                 1035             


His Gln  Phe Pro His Phe Leu  Glu Glu Asn Lys Ile  Ala Val Ser 
    1040                 1045                 1050             


<210>  2
<211>  3162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence of human SALL4A

<400>  2
atgtcgaggc gcaagcaggc gaaaccccag cacatcaact cggaggagga ccagggcgag       60

cagcagccgc agcagcagac cccggagttt gcagatgcgg ccccagcggc gcccgcggcg      120

ggggagctgg gtgctccagt gaaccaccca gggaatgacg aggtggcgag tgaggatgaa      180

gccacagtaa agcggcttcg tcgggaggag acgcacgtct gtgagaaatg ctgtgcggag      240

ttcttcagca tctctgagtt cctggaacat aagaaaaatt gcactaaaaa tccacctgtc      300

ctcatcatga atgacagcga ggggcctgtg ccttcagaag acttctccgg agctgtactg      360

agccaccagc ccaccagtcc cggcagtaag gactgtcaca gggagaatgg cggcagctca      420

gaggacatga aggagaagcc ggatgcggag tctgtggtgt acctaaagac agagacagcc      480

ctgccaccca ccccccagga cataagctat ttagccaaag gcaaagtggc caacactaat      540

gtgaccttgc aggcactacg gggcaccaag gtggcggtga atcagcggag cgcggatgca      600

ctccctgccc ccgtgcctgg tgccaacagc atcccgtggg tcctcgagca gatcttgtgt      660

ctgcagcagc agcagctaca gcagatccag ctcaccgagc agatccgcat ccaggtgaac      720

atgtgggcct cccacgccct ccactcaagc ggggcagggg ccgacactct gaagaccttg      780

ggcagccaca tgtctcagca ggtttctgca gctgtggctt tgctcagcca gaaagctgga      840

agccaaggtc tgtctctgga tgccttgaaa caagccaagc tacctcacgc caacatccct      900

tctgccacca gctccctgtc cccagggctg gcacccttca ctctgaagcc ggatgggacc      960

cgggtgctcc cgaacgtcat gtcccgcctc ccgagcgctt tgcttcctca ggccccgggc     1020

tcggtgctct tccagagccc tttctccact gtggcgctag acacatccaa gaaagggaag     1080

gggaagccac cgaacatctc cgcggtggat gtcaaaccca aagacgaggc ggccctctac     1140

aagcacaagt gtaagtactg tagcaaggtt tttgggactg atagctcctt gcagatccac     1200

ctccgctccc acactggaga gagacccttc gtgtgctctg tctgtggtca tcgcttcacc     1260

accaagggca acctcaaggt gcactttcac cgacatcccc aggtgaaggc aaacccccag     1320

ctgtttgccg agttccagga caaagtggcg gccggcaatg gcatccccta tgcactctct     1380

gtacctgacc ccatagatga accgagtctt tctttagaca gcaaacctgt ccttgtaacc     1440

acctctgtag ggctacctca gaatctttct tcggggacta atcccaagga cctcacgggt     1500

ggctccttgc ccggtgacct gcagcctggg ccttctccag aaagtgaggg tggacccaca     1560

ctccctgggg tgggaccaaa ctataattcc ccaagggctg gtggcttcca agggagtggg     1620

acccctgagc cagggtcaga gaccctgaaa ttgcagcagt tggtggagaa cattgacaag     1680

gccaccactg atcccaacga atgtctcatt tgccaccgag tcttaagctg tcagagctcc     1740

ctcaagatgc attatcgcac ccacaccggg gagagaccgt tccagtgtaa gatctgtggc     1800

cgagcctttt ctaccaaagg taacctgaag acacaccttg gggttcaccg aaccaacaca     1860

tccattaaga cgcagcattc gtgccccatc tgccagaaga agttcactaa tgccgtgatg     1920

ctgcagcaac atattcggat gcacatgggc ggtcagattc ccaacacgcc cctgccagag     1980

aatccctgtg actttacggg ttctgagcca atgaccgtgg gtgagaacgg cagcaccggc     2040

gctatctgcc atgatgatgt catcgaaagc atcgatgtag aggaagtcag ctcccaggag     2100

gctcccagca gctcctccaa ggtccccacg cctcttccca gcatccactc ggcatcaccc     2160

acgctagggt ttgccatgat ggcttcctta gatgccccag ggaaagtggg tcctgcccct     2220

tttaacctgc agcgccaggg cagcagagaa aacggttccg tggagagcga tggcttgacc     2280

aacgactcat cctcgctgat gggagaccag gagtatcaga gccgaagccc agatatcctg     2340

gaaaccacat ccttccaggc actctccccg gccaatagtc aagccgaaag catcaagtca     2400

aagtctcccg atgctgggag caaagcagag agctccgaga acagccgcac tgagatggaa     2460

ggtcggagca gtctcccttc cacgtttatc cgagccccgc cgacctatgt caaggttgaa     2520

gttcctggca catttgtggg accctcgaca ttgtccccag ggatgacccc tttgttagca     2580

gcccagccac gccgacaggc caagcaacat ggctgcacac ggtgtgggaa gaacttctcg     2640

tctgctagcg ctcttcagat ccacgagcgg actcacactg gagagaagcc ttttgtgtgc     2700

aacatttgtg ggcgagcttt taccaccaaa ggcaacttaa aggttcacta catgacacac     2760

ggggcgaaca ataactcagc ccgccgtgga aggaagttgg ccatcgagaa caccatggct     2820

ctgttaggta cggacggaaa aagagtctca gaaatctttc ccaaggaaat cctggcccct     2880

tcagtgaatg tggaccctgt tgtgtggaac cagtacacca gcatgctcaa tggcggtctg     2940

gccgtgaaga ccaatgagat ctctgtgatc cagagtgggg gggttcctac cctcccggtt     3000

tccttggggg ccacctccgt tgtgaataac gccactgtct ccaagatgga tggctcccag     3060

tcgggtatca gtgcagatgt ggaaaaacca agtgctactg acggcgttcc caaacaccag     3120

tttcctcact tcctggaaga aaacaagatt gcggtcagct aa                        3162


<210>  3
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  first zinc finger domain encompasses amino acid residues 405-432

<400>  3

Thr Gly Glu Arg Pro Phe Val Cys Ser Val Cys Gly His Arg Phe Thr 
1               5                   10                  15      


Thr Lys Gly Asn Leu Lys Val His Phe His Arg His 
            20                  25              


<210>  4
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  second zinc finger domain encompasses amino acid residues 589-616

<400>  4

Thr Gly Glu Arg Pro Phe Gln Cys Lys Ile Cys Gly Arg Ala Phe Ser 
1               5                   10                  15      


Thr Lys Gly Asn Leu Lys Thr His Leu Gly Val His 
            20                  25              


<210>  5
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  third zinc finger domain encompasses amino acid residues 865-892

<400>  5

Arg Gln Ala Lys Gln His Gly Cys Thr Arg Cys Gly Lys Asn Phe Ser 
1               5                   10                  15      


Ser Ala Ser Ala Leu Gln Ile His Glu Arg Thr His 
            20                  25              


<210>  6
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fourth zinc finger domain encompasses amino acid residues 893-920

<400>  6

Thr Gly Glu Lys Pro Phe Val Cys Asn Ile Cys Gly Arg Ala Phe Thr 
1               5                   10                  15      


Thr Lys Gly Asn Leu Lys Val His Tyr Met Thr His 
            20                  25              


<210>  7
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ikaros zinc finger domain (amino acid residues 140-168)

<400>  7

Thr Gly Glu Arg Pro Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr 
1               5                   10                  15      


Gln Lys Gly Asn Leu Leu Arg His Ile Lys Leu His Ser 
            20                  25                  


<210>  8
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ikaros (amino acid residues 145-167)

<400>  8

Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu 
1               5                   10                  15      


Leu Arg His Ile Lys Leu His 
            20              


<210>  9
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZFP91 (amino acid residues 400-422)

<400>  9

Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg Gln Lys Ala Ser Leu 
1               5                   10                  15      


Asn Trp His Met Lys Lys His 
            20              


<210>  10
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SALL4-ZF1

<400>  10

His Lys Cys Lys Tyr Cys Ser Lys Val Phe Gly Thr Asp Ser Ser Leu 
1               5                   10                  15      


Gln Ile His Leu Arg Ser His 
            20              


<210>  11
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SALL4-ZF2

<400>  11

Phe Val Cys Ser Val Cys Gly His Arg Phe Thr Thr Lys Gly Asn Leu 
1               5                   10                  15      


Lys Val His Phe His Arg His 
            20              


<210>  12
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SALL4-ZF3

<400>  12

Asn Glu Cys Leu Ile Cys His Arg Val Leu Ser Cys Gln Ser Ser Leu 
1               5                   10                  15      


Lys Met His Tyr Arg Thr His 
            20              


<210>  13

<400>  13
000

<210>  14
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SALL4-ZF4

<400>  14

Phe Gln Cys Lys Ile Cys Gly Arg Ala Phe Ser Thr Lys Gly Asn Leu 
1               5                   10                  15      


Lys Thr His Leu Gly Val His 
            20              


<210>  15
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SALL4-ZF5

<400>  15

His Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val Met Leu 
1               5                   10                  15      


Gln Gln His Ile Arg Met His 
            20              


<210>  16
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SALL4-ZF6

<400>  16

His Gly Cys Thr Arg Cys Gly Lys Asn Phe Ser Ser Ala Ser Ala Leu 
1               5                   10                  15      


Gln Ile His Glu Arg Thr His 
            20              


<210>  17
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SALL4-ZF7

<400>  17

Phe Val Cys Asn Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn Leu 
1               5                   10                  15      


Lys Val His Tyr Met Thr His 
            20              


<210>  18
<211>  442
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Cereblon

<400>  18

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser 
            180                 185                 190         


Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe 
        195                 200                 205             


Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp 
    210                 215                 220                 


Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp 
225                 230                 235                 240 


Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg 
                245                 250                 255     


Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser 
            260                 265                 270         


Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu 
        275                 280                 285             


Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala 
    290                 295                 300                 


Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser 
305                 310                 315                 320 


Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu 
                325                 330                 335     


Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro 
            340                 345                 350         


His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu 
        355                 360                 365             


Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr 
    370                 375                 380                 


Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp 
385                 390                 395                 400 


Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly 
                405                 410                 415     


Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu 
            420                 425                 430         


Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        435                 440         


<210>  19
<211>  487
<212>  PRT
<213>  Oryctolagus cuniculus

<220>
<223>  Rabbit Cereblon

<400>  19

Met Asp Ser Trp Arg Pro Leu Asp Arg Leu Ser Gln Ala Gly Ala Asp 
1               5                   10                  15      


Gly Glu Asp Glu Ser Glu Asp Glu Asp Glu Met Glu Val Glu Asp Gln 
            20                  25                  30          


Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn Phe Asp Thr Ser 
        35                  40                  45              


Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met Glu Glu Phe His 
    50                  55                  60                  


Gly Arg Thr Leu His Asp Asp Asp Ser Cys Pro Val Ile Pro Val Leu 
65                  70                  75                  80  


Pro Gln Val Val Met Ile Leu Ile Pro Gly Gln Thr Leu Pro Leu Gln 
                85                  90                  95      


Leu Ser His Pro Pro Glu Val Ser Met Val Arg Ser Leu Ile Gln Lys 
            100                 105                 110         


Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val Gln Glu Arg Glu 
        115                 120                 125             


Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr Arg Glu Glu Gln 
    130                 135                 140                 


Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Val Gly Arg Gln Arg 
145                 150                 155                 160 


Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly Ile Gln Gln Ala 
                165                 170                 175     


Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser Thr Met Ser Ala 
            180                 185                 190         


Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe Pro Ser Lys Pro 
        195                 200                 205             


Val Ser Trp Glu Asp Gln Cys Ser Tyr Lys Trp Trp Gln Lys Tyr Gln 
    210                 215                 220                 


Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp Pro Arg Trp Leu 
225                 230                 235                 240 


Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg Ile Lys Lys Gln 
                245                 250                 255     


Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser Leu Pro Ser Asn 
            260                 265                 270         


Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu Pro Ile Asp Asp 
        275                 280                 285             


Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala Ile Gln Arg Leu 
    290                 295                 300                 


Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser Leu Cys Cys Lys 
305                 310                 315                 320 


Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu Ile Phe Ser Leu 
                325                 330                 335     


Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro His Gly Tyr Val 
            340                 345                 350         


His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu Asn Leu Ile Gly 
        355                 360                 365             


Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr Ala Trp Thr Val 
    370                 375                 380                 


Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp Lys Phe Thr Ala 
385                 390                 395                 400 


Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly Leu Thr Arg Ser 
                405                 410                 415     


Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu Leu Ser Pro Asp 
            420                 425                 430         


Arg Ser Val Arg Leu Arg Gln His Thr Trp Asp Arg Gln Met His Ser 
        435                 440                 445             


Arg His Thr Arg Asp Pro Thr Tyr Val Ala Arg Gly Arg Arg Pro Val 
    450                 455                 460                 


Gly Ser Ala Val Leu Gly Arg Lys Arg Trp Leu Cys Val Ala Val Asp 
465                 470                 475                 480 


Ser Gln Gly Cys Val Thr Pro 
                485         


<210>  20
<211>  445
<212>  PRT
<213>  Mus

<220>
<223>  Mouse Cereblon

<400>  20

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Asp Ser Glu Asp Glu Asp Asp Glu Ile 
            20                  25                  30          


Glu Met Glu Val Glu Asp Gln Asp Ser Lys Glu Ala Arg Lys Pro Asn 
        35                  40                  45              


Ile Ile Asn Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly 
    50                  55                  60                  


Ala Asp Met Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser 
65                  70                  75                  80  


Cys Gln Val Ile Pro Val Leu Pro Glu Val Leu Met Ile Leu Ile Pro 
                85                  90                  95      


Gly Gln Thr Leu Pro Leu Gln Leu Ser His Pro Gln Glu Val Ser Met 
            100                 105                 110         


Val Arg Asn Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr 
        115                 120                 125             


Ser Asn Val Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile 
    130                 135                 140                 


Tyr Ala Tyr Arg Glu Glu Gln Glu Phe Gly Ile Glu Val Val Lys Val 
145                 150                 155                 160 


Lys Ala Ile Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln 
                165                 170                 175     


Ser Asp Gly Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val 
            180                 185                 190         


Leu Pro Ser Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys 
        195                 200                 205             


Gln Val Phe Pro Ser Lys Pro Ile Ser Trp Glu Asp Gln Tyr Ser Cys 
    210                 215                 220                 


Lys Trp Trp Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu 
225                 230                 235                 240 


Thr Ser Trp Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu 
                245                 250                 255     


Met Asp Arg Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys 
            260                 265                 270         


Asp Asp Ser Leu Pro Glu Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala 
        275                 280                 285             


Ala Cys Leu Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile 
    290                 295                 300                 


Gly Ser Ala Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys 
305                 310                 315                 320 


Cys Thr Ser Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr 
                325                 330                 335     


Lys Asn Glu Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr 
            340                 345                 350         


Val Asn Pro His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala 
        355                 360                 365             


Ser Asn Leu Asn Leu Ile Gly Arg Pro Ser Thr Val His Ser Trp Phe 
    370                 375                 380                 


Pro Gly Tyr Ala Trp Thr Ile Ala Gln Cys Lys Ile Cys Ala Ser His 
385                 390                 395                 400 


Ile Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys 
                405                 410                 415     


Phe Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Glu Thr 
            420                 425                 430         


Glu Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        435                 440                 445 


<210>  21
<211>  1053
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human SALL4A

<400>  21

Met Ser Arg Arg Lys Gln Ala Lys Pro Gln His Ile Asn Ser Glu Glu 
1               5                   10                  15      


Asp Gln Gly Glu Gln Gln Pro Gln Gln Gln Thr Pro Glu Phe Ala Asp 
            20                  25                  30          


Ala Ala Pro Ala Ala Pro Ala Ala Gly Glu Leu Gly Ala Pro Val Asn 
        35                  40                  45              


His Pro Gly Asn Asp Glu Val Ala Ser Glu Asp Glu Ala Thr Val Lys 
    50                  55                  60                  


Arg Leu Arg Arg Glu Glu Thr His Val Cys Glu Lys Cys Cys Ala Glu 
65                  70                  75                  80  


Phe Phe Ser Ile Ser Glu Phe Leu Glu His Lys Lys Asn Cys Thr Lys 
                85                  90                  95      


Asn Pro Pro Val Leu Ile Met Asn Asp Ser Glu Gly Pro Val Pro Ser 
            100                 105                 110         


Glu Asp Phe Ser Gly Ala Val Leu Ser His Gln Pro Thr Ser Pro Gly 
        115                 120                 125             


Ser Lys Asp Cys His Arg Glu Asn Gly Gly Ser Ser Glu Asp Met Lys 
    130                 135                 140                 


Glu Lys Pro Asp Ala Glu Ser Val Val Tyr Leu Lys Thr Glu Thr Ala 
145                 150                 155                 160 


Leu Pro Pro Thr Pro Gln Asp Ile Ser Tyr Leu Ala Lys Gly Lys Val 
                165                 170                 175     


Ala Asn Thr Asn Val Thr Leu Gln Ala Leu Arg Gly Thr Lys Val Ala 
            180                 185                 190         


Val Asn Gln Arg Ser Ala Asp Ala Leu Pro Ala Pro Val Pro Gly Ala 
        195                 200                 205             


Asn Ser Ile Pro Trp Val Leu Glu Gln Ile Leu Cys Leu Gln Gln Gln 
    210                 215                 220                 


Gln Leu Gln Gln Ile Gln Leu Thr Glu Gln Ile Arg Ile Gln Val Asn 
225                 230                 235                 240 


Met Trp Ala Ser His Ala Leu His Ser Ser Gly Ala Gly Ala Asp Thr 
                245                 250                 255     


Leu Lys Thr Leu Gly Ser His Met Ser Gln Gln Val Ser Ala Ala Val 
            260                 265                 270         


Ala Leu Leu Ser Gln Lys Ala Gly Ser Gln Gly Leu Ser Leu Asp Ala 
        275                 280                 285             


Leu Lys Gln Ala Lys Leu Pro His Ala Asn Ile Pro Ser Ala Thr Ser 
    290                 295                 300                 


Ser Leu Ser Pro Gly Leu Ala Pro Phe Thr Leu Lys Pro Asp Gly Thr 
305                 310                 315                 320 


Arg Val Leu Pro Asn Val Met Ser Arg Leu Pro Ser Ala Leu Leu Pro 
                325                 330                 335     


Gln Ala Pro Gly Ser Val Leu Phe Gln Ser Pro Phe Ser Thr Val Ala 
            340                 345                 350         


Leu Asp Thr Ser Lys Lys Gly Lys Gly Lys Pro Pro Asn Ile Ser Ala 
        355                 360                 365             


Val Asp Val Lys Pro Lys Asp Glu Ala Ala Leu Tyr Lys His Lys Cys 
    370                 375                 380                 


Lys Tyr Cys Ser Lys Val Phe Gly Thr Asp Ser Ser Leu Gln Ile His 
385                 390                 395                 400 


Leu Arg Ser His Thr Gly Glu Arg Pro Phe Val Cys Ser Val Cys Gly 
                405                 410                 415     


His Arg Phe Thr Thr Lys Gly Asn Leu Lys Val His Phe His Arg His 
            420                 425                 430         


Pro Gln Val Lys Ala Asn Pro Gln Leu Phe Ala Glu Phe Gln Asp Lys 
        435                 440                 445             


Val Ala Ala Gly Asn Gly Ile Pro Tyr Ala Leu Ser Val Pro Asp Pro 
    450                 455                 460                 


Ile Asp Glu Pro Ser Leu Ser Leu Asp Ser Lys Pro Val Leu Val Thr 
465                 470                 475                 480 


Thr Ser Val Gly Leu Pro Gln Asn Leu Ser Ser Gly Thr Asn Pro Lys 
                485                 490                 495     


Asp Leu Thr Gly Gly Ser Leu Pro Gly Asp Leu Gln Pro Gly Pro Ser 
            500                 505                 510         


Pro Glu Ser Glu Gly Gly Pro Thr Leu Pro Gly Val Gly Pro Asn Tyr 
        515                 520                 525             


Asn Ser Pro Arg Ala Gly Gly Phe Gln Gly Ser Gly Thr Pro Glu Pro 
    530                 535                 540                 


Gly Ser Glu Thr Leu Lys Leu Gln Gln Leu Val Glu Asn Ile Asp Lys 
545                 550                 555                 560 


Ala Thr Thr Asp Pro Asn Glu Cys Leu Ile Cys His Arg Val Leu Ser 
                565                 570                 575     


Cys Gln Ser Ser Leu Lys Met His Tyr Arg Thr His Thr Gly Glu Arg 
            580                 585                 590         


Pro Phe Gln Cys Lys Ile Cys Gly Arg Ala Phe Ser Thr Lys Gly Asn 
        595                 600                 605             


Leu Lys Thr His Leu Gly Val His Arg Thr Asn Thr Ser Ile Lys Thr 
    610                 615                 620                 


Gln His Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val Met 
625                 630                 635                 640 


Leu Gln Gln His Ile Arg Met His Met Gly Gly Gln Ile Pro Asn Thr 
                645                 650                 655     


Pro Leu Pro Glu Asn Pro Cys Asp Phe Thr Gly Ser Glu Pro Met Thr 
            660                 665                 670         


Val Gly Glu Asn Gly Ser Thr Gly Ala Ile Cys His Asp Asp Val Ile 
        675                 680                 685             


Glu Ser Ile Asp Val Glu Glu Val Ser Ser Gln Glu Ala Pro Ser Ser 
    690                 695                 700                 


Ser Ser Lys Val Pro Thr Pro Leu Pro Ser Ile His Ser Ala Ser Pro 
705                 710                 715                 720 


Thr Leu Gly Phe Ala Met Met Ala Ser Leu Asp Ala Pro Gly Lys Val 
                725                 730                 735     


Gly Pro Ala Pro Phe Asn Leu Gln Arg Gln Gly Ser Arg Glu Asn Gly 
            740                 745                 750         


Ser Val Glu Ser Asp Gly Leu Thr Asn Asp Ser Ser Ser Leu Met Gly 
        755                 760                 765             


Asp Gln Glu Tyr Gln Ser Arg Ser Pro Asp Ile Leu Glu Thr Thr Ser 
    770                 775                 780                 


Phe Gln Ala Leu Ser Pro Ala Asn Ser Gln Ala Glu Ser Ile Lys Ser 
785                 790                 795                 800 


Lys Ser Pro Asp Ala Gly Ser Lys Ala Glu Ser Ser Glu Asn Ser Arg 
                805                 810                 815     


Thr Glu Met Glu Gly Arg Ser Ser Leu Pro Ser Thr Phe Ile Arg Ala 
            820                 825                 830         


Pro Pro Thr Tyr Val Lys Val Glu Val Pro Gly Thr Phe Val Gly Pro 
        835                 840                 845             


Ser Thr Leu Ser Pro Gly Met Thr Pro Leu Leu Ala Ala Gln Pro Arg 
    850                 855                 860                 


Arg Gln Ala Lys Gln His Gly Cys Thr Arg Cys Gly Lys Asn Phe Ser 
865                 870                 875                 880 


Ser Ala Ser Ala Leu Gln Ile His Glu Arg Thr His Thr Gly Glu Lys 
                885                 890                 895     


Pro Phe Val Cys Asn Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn 
            900                 905                 910         


Leu Lys Val His Tyr Met Thr His Gly Ala Asn Asn Asn Ser Ala Arg 
        915                 920                 925             


Arg Gly Arg Lys Leu Ala Ile Glu Asn Thr Met Ala Leu Leu Gly Thr 
    930                 935                 940                 


Asp Gly Lys Arg Val Ser Glu Ile Phe Pro Lys Glu Ile Leu Ala Pro 
945                 950                 955                 960 


Ser Val Asn Val Asp Pro Val Val Trp Asn Gln Tyr Thr Ser Met Leu 
                965                 970                 975     


Asn Gly Gly Leu Ala Val Lys Thr Asn Glu Ile Ser Val Ile Gln Ser 
            980                 985                 990         


Gly Gly Val Pro Thr Leu Pro Val  Ser Leu Gly Ala Thr  Ser Val Val 
        995                 1000                 1005             


Asn Asn  Ala Thr Val Ser Lys  Met Asp Gly Ser Gln  Ser Gly Ile 
    1010                 1015                 1020             


Ser Ala  Asp Val Glu Lys Pro  Ser Ala Thr Asp Gly  Val Pro Lys 
    1025                 1030                 1035             


His Gln  Phe Pro His Phe Leu  Glu Glu Asn Lys Ile  Ala Val Ser 
    1040                 1045                 1050             


<210>  22
<211>  993
<212>  PRT
<213>  Oryctolagus cuniculus

<220>
<223>  Rabbit SALL4A

<400>  22

Gly Ala Ala Met Asn Gln Pro Gly Thr Gly Asp Asp Ala Pro Gly Asp 
1               5                   10                  15      


Arg Val Pro Gly Lys Arg Pro Arg Arg Glu Glu Thr His Ile Cys Glu 
            20                  25                  30          


Lys Cys Cys Ala Glu Phe Phe Ser Leu Ser Glu Phe Leu Glu His Lys 
        35                  40                  45              


Lys Asn Cys Thr Lys Asn Pro Pro Val Leu Ile Met Ser Asp Ser Glu 
    50                  55                  60                  


Gly Pro Val Pro Ser Glu Asp Phe Ser Gly Ala Val Leu Ser Pro Gly 
65                  70                  75                  80  


Gly Arg Asp Ser His Arg Glu Ser Gly Gly Ser Ser Gly Asp Thr Lys 
                85                  90                  95      


Glu Lys Leu Gly Ala Glu Ser Val Val His Leu Lys Ala Glu Thr Thr 
            100                 105                 110         


Leu Pro Pro Pro Pro Gln Asp Ile Ser Tyr Val Pro Lys Gly Lys Val 
        115                 120                 125             


Ala Ser Thr Asn Val Thr Leu Gln Ala Leu Arg Gly Thr Lys Val Ala 
    130                 135                 140                 


Val Asn Gln Arg Ser Ala Asp Ala Pro Pro Ala Pro Val Pro Gly Ala 
145                 150                 155                 160 


Asn Ser Ile Pro Trp Val Leu Glu Gln Ile Leu Cys Leu Gln Gln Gln 
                165                 170                 175     


Gln Leu Gln Gln Ile Gln Leu Thr Glu Gln Ile Arg Ile Gln Val Asn 
            180                 185                 190         


Met Trp Ala Ser His Ala Leu His Ser Gly Val Ala Gly Ala Asp Ala 
        195                 200                 205             


Leu Lys Thr Leu Gly Gly His Val Ser Gln Gln Val Ser Ala Ala Val 
    210                 215                 220                 


Ala Leu Leu Ser Gln Lys Ala Gly Ser Gln Gly Leu Ser Leu Glu Ala 
225                 230                 235                 240 


Leu Lys Gln Gly Lys Leu Pro His Ala Ser Ile Pro Ser Ala Ala Gly 
                245                 250                 255     


Ser Leu Ser Ser Gly Leu Thr Pro Phe Ala Leu Lys Pro Asp Gly Ala 
            260                 265                 270         


Arg Val Leu Pro Ser Val Met Ser Arg Leu Pro Ser Ala Leu Leu Pro 
        275                 280                 285             


Gln Thr Pro Gly Pro Ala Leu Phe Gln Gly Pro Phe Ser Thr Val Ala 
    290                 295                 300                 


Leu Asp Pro Ser Lys Lys Gly Lys Gly Lys Pro Pro Ser Val Ser Ala 
305                 310                 315                 320 


Val Asp Val Lys Thr Lys Asp Glu Thr Gly Leu Cys Lys His Lys Cys 
                325                 330                 335     


Lys Tyr Cys Ser Lys Val Phe Gly Thr Asp Ser Ser Leu Gln Ile His 
            340                 345                 350         


Leu Arg Ser His Thr Gly Glu Arg Pro Phe Val Cys Ser Val Cys Gly 
        355                 360                 365             


His Arg Phe Thr Thr Lys Gly Asn Leu Lys Val His Phe His Arg His 
    370                 375                 380                 


Pro Gln Val Lys Ala Asn Pro Gln Leu Phe Ala Glu Phe Gln Asp Lys 
385                 390                 395                 400 


Val Ala Ala Gly Ser Gly Val Pro Phe Ala Leu Ser Val Pro Val Pro 
                405                 410                 415     


Val Asp Gly Ala Ser Leu Ser Val Asp Ser Lys Pro Val Leu Ala Thr 
            420                 425                 430         


Gly Ala Pro Ser Val Gly Leu Pro Gln Asn Leu Ser Ser Gly Thr Asn 
        435                 440                 445             


Pro Lys Asp Leu Leu Gly Ala Pro Leu Pro Ser Asp Leu Gln Pro Pro 
    450                 455                 460                 


Gly Pro Ser Pro Glu Ser Glu Gly Gly Leu Ala Leu Ala Gly Val Gly 
465                 470                 475                 480 


Pro Asn His Ile Ser Pro Arg Val Gly Gly Phe Gln Gly Ser Ala Val 
                485                 490                 495     


Pro Glu Pro Gly Ser Glu Thr Leu Lys Leu Gln Gln Leu Val Glu Asn 
            500                 505                 510         


Ile Asp Lys Ala Thr Thr Asp Pro Asn Glu Cys Leu Ile Cys His Arg 
        515                 520                 525             


Val Leu Ser Cys Gln Ser Ser Leu Lys Met His Tyr Arg Thr His Thr 
    530                 535                 540                 


Gly Glu Arg Pro Phe Gln Cys Lys Val Cys Gly Arg Ala Phe Ser Thr 
545                 550                 555                 560 


Gly Asn Leu Lys Thr His Leu Gly Val His Arg Thr Asn Pro Ala Val 
                565                 570                 575     


Lys Thr Gln His Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala 
            580                 585                 590         


Val Leu Leu Gln Gln His Ile Arg Met His Met Gly Gly Gln Ile Pro 
        595                 600                 605             


Asn Thr Pro Leu Pro Glu Gly Pro Cys Asp Phe Cys His Asp Asp Ser 
    610                 615                 620                 


Glu Gly Val Asp Leu Asp Glu Val Ser Leu Gln Asp Val Pro Ser Gly 
625                 630                 635                 640 


Ser Ser Lys Val Pro Ala Pro Leu Pro Gly Val His Ser Ala Ser Pro 
                645                 650                 655     


Thr Leu Gly Phe Pro Val Arg Ala Ser Leu Asp Ala Ala Gly Lys Ala 
            660                 665                 670         


Gly Ala Ala Pro Leu Gly Leu Gln Arg Gln Ser Ser Arg Glu Asn Gly 
        675                 680                 685             


Ser Val Glu Ser Asp Gly Leu Thr Asn Asp Ser Ser Ser Leu Ile Glu 
    690                 695                 700                 


Asp Pro Glu Tyr Gln Ser Arg Ser Pro Asp Ala Ala Glu Ser Ala Ser 
705                 710                 715                 720 


Phe Gln Ala Pro Ser Pro Ala Asn Ser Gln Ala Glu Ser Val Lys Ser 
                725                 730                 735     


Arg Ser Pro Asp Ala Gly Ser Arg Ala Glu Ser Ser Glu Met Gly Gly 
            740                 745                 750         


His Cys Ser Leu Ala Thr Glu Pro Gly Arg Ser Ser Leu Pro Ser Thr 
        755                 760                 765             


Phe Ile Arg Thr Gln Pro Thr Tyr Val Lys Val Glu Val Pro Gly Pro 
    770                 775                 780                 


Phe Val Gly Pro Ser Thr Leu Ser Pro Gly Thr Thr Pro Leu Leu Val 
785                 790                 795                 800 


Ala Gln Pro Arg Arg Gln Ala Lys Gln His Gly Cys Thr Arg Cys Gly 
                805                 810                 815     


Lys Asn Phe Ser Ser Ala Ser Ala Leu Gln Ile His Glu Arg Thr His 
            820                 825                 830         


Thr Gly Glu Lys Pro Phe Val Cys Asn Ile Cys Gly Arg Ala Phe Thr 
        835                 840                 845             


Thr Lys Gly Asn Leu Lys Val His Tyr Met Thr His Gly Ala Asn Asn 
    850                 855                 860                 


Asn Ser Ala Arg Arg Gly Arg Lys Leu Ala Ile Glu Asn Thr Met Ala 
865                 870                 875                 880 


Leu Leu Gly Thr Asp Gly Lys Arg Val Ser Glu Met Phe Pro Lys Glu 
                885                 890                 895     


Ile Leu Ala Pro Ser Val Asn Val Asp Pro Val Met Trp Thr Gln Tyr 
            900                 905                 910         


Thr Ser Met Leu Asn Gly Gly Met Ala Val Lys Thr Asn Glu Ile Ser 
        915                 920                 925             


Val Ile Gln Ser Gly Gly Leu Pro Thr Leu Pro Val Ser Leu Gly Ala 
    930                 935                 940                 


Ser Ser Val Val Ser Asn Ala Thr Val Ser Lys Leu Asp Gly Ser Gln 
945                 950                 955                 960 


Ser Gly Ile Ser Ala Asp Ala Glu Lys Pro Gly Ala Ala Asp Gly Val 
                965                 970                 975     


Ala Lys His Gln Phe Pro His Phe Leu Glu Glu Lys Lys Ile Ala Val 
            980                 985                 990         


Ser 
    


<210>  23
<211>  1067
<212>  PRT
<213>  Mus

<220>
<223>  Mouse SALL4A

<400>  23

Met Ser Arg Arg Lys Gln Ala Lys Pro Gln His Ile Asn Trp Glu Glu 
1               5                   10                  15      


Gly Gln Gly Glu Gln Pro Gln Gln Leu Pro Ser Pro Asp Leu Ala Glu 
            20                  25                  30          


Ala Leu Ala Ala Glu Glu Pro Gly Ala Pro Val Asn Ser Pro Gly Asn 
        35                  40                  45              


Cys Asp Glu Ala Ser Glu Asp Ser Ile Pro Val Lys Arg Pro Arg Arg 
    50                  55                  60                  


Glu Asp Thr His Ile Cys Asn Lys Cys Cys Ala Glu Phe Phe Ser Leu 
65                  70                  75                  80  


Ser Glu Phe Met Glu His Lys Lys Ser Cys Thr Lys Thr Pro Pro Val 
                85                  90                  95      


Leu Ile Met Asn Asp Ser Glu Gly Pro Val Pro Ser Glu Asp Phe Ser 
            100                 105                 110         


Arg Ala Ala Leu Ser His Gln Leu Gly Ser Pro Ser Asn Lys Asp Ser 
        115                 120                 125             


Leu Gln Glu Asn Gly Ser Ser Ser Gly Asp Leu Lys Lys Leu Gly Thr 
    130                 135                 140                 


Asp Ser Ile Leu Tyr Leu Lys Thr Glu Ala Thr Gln Pro Ser Thr Pro 
145                 150                 155                 160 


Gln Asp Ile Ser Tyr Leu Pro Lys Gly Lys Val Ala Asn Thr Asn Val 
                165                 170                 175     


Thr Leu Gln Ala Leu Arg Gly Thr Lys Val Ala Val Asn Gln Arg Gly 
            180                 185                 190         


Ala Glu Ala Pro Met Ala Pro Met Pro Ala Ala Gln Gly Ile Pro Trp 
        195                 200                 205             


Val Leu Glu Gln Ile Leu Cys Leu Gln Gln Gln Gln Leu Gln Gln Ile 
    210                 215                 220                 


Gln Leu Thr Glu Gln Ile Arg Val Gln Val Asn Met Trp Ala Ala His 
225                 230                 235                 240 


Ala Leu His Ser Gly Val Ala Gly Ala Asp Thr Leu Lys Ala Leu Ser 
                245                 250                 255     


Ser His Val Ser Gln Gln Val Ser Val Ser Gln Gln Val Ser Ala Ala 
            260                 265                 270         


Val Ala Leu Leu Ser Gln Lys Ala Ser Asn Pro Ala Leu Ser Leu Asp 
        275                 280                 285             


Ala Leu Lys Gln Ala Lys Leu Pro His Ala Ser Val Pro Ser Ala Ala 
    290                 295                 300                 


Ser Pro Leu Ser Ser Gly Leu Thr Ser Phe Thr Leu Lys Pro Asp Gly 
305                 310                 315                 320 


Thr Arg Val Leu Pro Asn Phe Val Ser Arg Leu Pro Ser Ala Leu Leu 
                325                 330                 335     


Pro Gln Thr Pro Gly Ser Val Leu Leu Gln Ser Pro Phe Ser Ala Val 
            340                 345                 350         


Thr Leu Asp Gln Ser Lys Lys Gly Lys Gly Lys Pro Gln Asn Leu Ser 
        355                 360                 365             


Ala Ser Ala Ser Val Leu Asp Val Lys Ala Lys Asp Glu Val Val Leu 
    370                 375                 380                 


Gly Lys His Lys Cys Arg Tyr Cys Pro Lys Val Phe Gly Thr Asp Ser 
385                 390                 395                 400 


Ser Leu Gln Ile His Leu Arg Ser His Thr Gly Glu Arg Pro Tyr Val 
                405                 410                 415     


Cys Pro Ile Cys Gly His Arg Phe Thr Thr Lys Gly Asn Leu Lys Val 
            420                 425                 430         


His Leu Gln Arg His Pro Glu Val Lys Ala Asn Pro Gln Leu Leu Ala 
        435                 440                 445             


Glu Phe Gln Asp Lys Gly Ala Val Ser Ala Ala Ser His Tyr Ala Leu 
    450                 455                 460                 


Pro Val Pro Val Pro Ala Asp Glu Ser Ser Leu Ser Val Asp Ala Glu 
465                 470                 475                 480 


Pro Val Pro Val Thr Gly Thr Pro Ser Leu Gly Leu Pro Gln Lys Leu 
                485                 490                 495     


Thr Ser Gly Pro Asn Ser Arg Asp Leu Met Gly Gly Ser Leu Pro Asn 
            500                 505                 510         


Asp Met Gln Pro Gly Pro Ser Pro Glu Ser Glu Ala Gly Leu Pro Leu 
        515                 520                 525             


Leu Gly Val Gly Met Ile His Asn Pro Pro Lys Ala Gly Gly Phe Gln 
    530                 535                 540                 


Gly Thr Gly Ala Pro Glu Ser Gly Ser Glu Thr Leu Lys Leu Gln Gln 
545                 550                 555                 560 


Leu Val Glu Asn Ile Asp Lys Ala Thr Thr Asp Pro Asn Glu Cys Leu 
                565                 570                 575     


Ile Cys His Arg Val Leu Ser Cys Gln Ser Ser Leu Lys Met His Tyr 
            580                 585                 590         


Arg Thr His Thr Gly Glu Arg Pro Phe Gln Cys Lys Ile Cys Gly Arg 
        595                 600                 605             


Ala Phe Ser Thr Lys Gly Asn Leu Lys Thr His Leu Gly Val His Arg 
    610                 615                 620                 


Thr Asn Thr Thr Val Lys Thr Gln His Ser Cys Pro Ile Cys Gln Lys 
625                 630                 635                 640 


Lys Phe Thr Asn Ala Val Met Leu Gln Gln His Ile Arg Met His Met 
                645                 650                 655     


Gly Gly Gln Ile Pro Asn Thr Pro Leu Pro Glu Ser Pro Cys Asp Phe 
            660                 665                 670         


Thr Ala Pro Glu Pro Val Ala Val Ser Glu Asn Gly Ser Ala Ser Gly 
        675                 680                 685             


Val Cys Gln Asp Asp Ala Ala Glu Gly Met Glu Ala Glu Glu Val Cys 
    690                 695                 700                 


Ser Gln Asp Val Pro Ser Gly Pro Ser Thr Val Ser Leu Pro Val Pro 
705                 710                 715                 720 


Ser Ala His Leu Ala Ser Pro Ser Leu Gly Phe Ser Val Leu Ala Ser 
                725                 730                 735     


Leu Asp Thr Gln Gly Lys Gly Ala Leu Pro Ala Leu Ala Leu Gln Arg 
            740                 745                 750         


Gln Ser Ser Arg Glu Asn Ser Ser Leu Glu Gly Gly Asp Thr Gly Pro 
        755                 760                 765             


Ala Asn Asp Ser Ser Leu Leu Val Gly Asp Gln Glu Cys Gln Ser Arg 
    770                 775                 780                 


Ser Pro Asp Ala Thr Glu Thr Met Cys Tyr Gln Ala Val Ser Pro Ala 
785                 790                 795                 800 


Asn Ser Gln Ala Gly Ser Val Lys Ser Arg Ser Pro Glu Gly His Lys 
                805                 810                 815     


Ala Glu Gly Val Glu Ser Cys Arg Val Asp Thr Glu Gly Arg Thr Ser 
            820                 825                 830         


Leu Pro Pro Thr Phe Ile Arg Ala Gln Pro Thr Phe Val Lys Val Glu 
        835                 840                 845             


Val Pro Gly Thr Phe Val Gly Pro Pro Ser Met Pro Ser Gly Met Pro 
    850                 855                 860                 


Pro Leu Leu Ala Ser Gln Pro Gln Pro Arg Arg Gln Ala Lys Gln His 
865                 870                 875                 880 


Cys Cys Thr Arg Cys Gly Lys Asn Phe Ser Ser Ala Ser Ala Leu Gln 
                885                 890                 895     


Ile His Glu Arg Thr His Thr Gly Glu Lys Pro Phe Val Cys Asn Ile 
            900                 905                 910         


Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn Leu Lys Val His Tyr Met 
        915                 920                 925             


Thr His Gly Ala Asn Asn Asn Ser Ala Arg Arg Gly Arg Lys Leu Ala 
    930                 935                 940                 


Ile Glu Asn Pro Met Ala Ala Leu Ser Ala Glu Gly Lys Arg Ala Pro 
945                 950                 955                 960 


Glu Val Phe Ser Lys Glu Leu Leu Ser Pro Ala Val Ser Val Asp Pro 
                965                 970                 975     


Ala Ser Trp Asn Gln Tyr Thr Ser Val Leu Asn Gly Gly Leu Ala Met 
            980                 985                 990         


Lys Thr Asn Glu Ile Ser Val Ile  Gln Ser Gly Gly Ile  Pro Thr Leu 
        995                 1000                 1005             


Pro Val  Ser Leu Gly Ala Ser  Ser Val Val Ser Asn  Gly Thr Ile 
    1010                 1015                 1020             


Ser Lys  Leu Asp Gly Ser Gln  Thr Gly Val Ser Met  Pro Met Ser 
    1025                 1030                 1035             


Gly Asn  Gly Glu Lys Leu Ala  Val Pro Asp Gly Met  Ala Lys His 
    1040                 1045                 1050             


Gln Phe  Pro His Phe Leu Glu  Glu Asn Lys Ile Ala  Val Ser 
    1055                 1060                 1065         


