                         SEQUENCE LISTING

<110>  NEW YORK UNIVERSITY
 
<120>  SOLUBLE ALPHA-KLOTHO PROTEINS, PROTEIN FRAGMENTS, AND USES 
       THEREOF

<130>  29527.2051 (MOH01-09PCT)

<150>  62/616,945
<151>  2018-01-12

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  981
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wildtype Human alpha-Klotho

<400>  1

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser 
            980     


<210>  2
<211>  932
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified soluble alpha-Klotho protein

<400>  2

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
    530                 535                 540                 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
545                 550                 555                 560 


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
                565                 570                 575     


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
            580                 585                 590         


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
        595                 600                 605             


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
    610                 615                 620                 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
625                 630                 635                 640 


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
                645                 650                 655     


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
            660                 665                 670         


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
        675                 680                 685             


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
    690                 695                 700                 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
705                 710                 715                 720 


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
                725                 730                 735     


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
            740                 745                 750         


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
        755                 760                 765             


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
    770                 775                 780                 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
785                 790                 795                 800 


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
                805                 810                 815     


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
            820                 825                 830         


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
        835                 840                 845             


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
    850                 855                 860                 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
865                 870                 875                 880 


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
                885                 890                 895     


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
            900                 905                 910         


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
        915                 920                 925             


Thr Arg Lys Ser 
    930         


<210>  3
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-Klotho receptor binding arm portion

<400>  3

Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
1               5                   10                  15      


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
            20                  25                  30          


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
        35                  40                  45              


Ile 
    


<210>  4
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human FGF23

<400>  4

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210>  5
<211>  3039
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human alpha-Klotho gene coding sequence

<400>  5
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtttctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gatacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc     1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc     1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc     1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct     1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc     1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac     2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc     2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat     2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct     2220

ttctcccaaa aggacaaaga ggtggctgag agagttttgg aatttgacat tggctggctg     2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa     2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc     2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat     2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac     2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag     2580

ttcaagtacg gagacctccc catgtacata atatccaatg gaatcgatga cgggctgcat     2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa     2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc     2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc     2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa     2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag     2940

tctttactgg ctttcatagc ttttctattt tttgcttcta ttatttctct ctcccttata     3000

ttttactact cgaagaaagg cagaagaagt tacaaatag                            3039


<210>  6
<211>  2880
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule encoding alpha-Klotho ectodomain/delta RBA

<400>  6
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtttctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gatacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgaca agaagaggaa atcctactgt gttgactttg ctgccatcca gccccagatc     1680

gctttactcc aggaaatgca cgttacacat tttcgcttct ccctggactg ggccctgatt     1740

ctccctctgg gtaaccagtc ccaggtgaac cacaccatcc tgcagtacta tcgctgcatg     1800

gccagcgagc ttgtccgtgt caacatcacc ccagtggtgg ccctgtggca gcctatggcc     1860

ccgaaccaag gactgccgcg cctcctggcc aggcagggcg cctgggagaa cccctacact     1920

gccctggcct ttgcagagta tgcccgactg tgctttcaag agctcggcca tcacgtcaag     1980

ctttggataa cgatgaatga gccgtataca aggaatatga catacagtgc tggccacaac     2040

cttctgaagg cccatgccct ggcttggcat gtgtacaatg aaaagtttag gcatgctcag     2100

aatgggaaaa tatccatagc cttgcaggct gattggatag aacctgcctg ccctttctcc     2160

caaaaggaca aagaggtggc tgagagagtt ttggaatttg acattggctg gctggctgag     2220

cccattttcg gctctggaga ttatccatgg gtgatgaggg actggctgaa ccaaagaaac     2280

aattttcttc ttccttattt cactgaagat gaaaaaaagc taatccaggg tacctttgac     2340

tttttggctt taagccatta taccaccatc cttgtagact cagaaaaaga agatccaata     2400

aaatacaatg attacctaga agtgcaagaa atgaccgaca tcacgtggct caactccccc     2460

agtcaggtgg cggtagtgcc ctgggggttg cgcaaagtgc tgaactggct gaagttcaag     2520

tacggagacc tccccatgta cataatatcc aatggaatcg atgacgggct gcatgctgag     2580

gacgaccagc tgagggtgta ttatatgcag aattacataa acgaagctct caaagcccac     2640

atactggatg gtatcaatct ttgcggatac tttgcttatt cgtttaacga ccgcacagct     2700

ccgaggtttg gcctctatcg ttatgctgca gatcagtttg agcccaaggc atccatgaaa     2760

cattacagga aaattattga cagcaatggt ttcccgggcc cagaaactct ggaaagattt     2820

tgtccagaag aattcaccgt gtgtactgag tgcagttttt ttcacacccg aaagtcttag     2880


<210>  7
<211>  959
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-Klotho ectodomain/delta RBA

<400>  7

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Lys 
    530                 535                 540                 


Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln Pro Gln Ile 
545                 550                 555                 560 


Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg Phe Ser Leu Asp 
                565                 570                 575     


Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val Asn His Thr 
            580                 585                 590         


Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val Arg Val Asn 
        595                 600                 605             


Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro Asn Gln Gly 
    610                 615                 620                 


Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr 
625                 630                 635                 640 


Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly 
                645                 650                 655     


His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn 
            660                 665                 670         


Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His Ala Leu Ala 
        675                 680                 685             


Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn Gly Lys Ile 
    690                 695                 700                 


Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser 
705                 710                 715                 720 


Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe Asp Ile Gly 
                725                 730                 735     


Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro Trp Val Met 
            740                 745                 750         


Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr 
        755                 760                 765             


Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu 
    770                 775                 780                 


Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu Asp Pro Ile 
785                 790                 795                 800 


Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp Ile Thr Trp 
                805                 810                 815     


Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly Leu Arg Lys 
            820                 825                 830         


Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile 
        835                 840                 845             


Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala Glu Asp Asp Gln Leu 
    850                 855                 860                 


Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu Lys Ala His 
865                 870                 875                 880 


Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn 
                885                 890                 895     


Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln 
            900                 905                 910         


Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg Lys Ile Ile Asp Ser 
        915                 920                 925             


Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu 
    930                 935                 940                 


Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His Thr Arg Lys Ser 
945                 950                 955                 


<210>  8
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human FGF21

<400>  8

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  9
<211>  822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human FGFR1c

<400>  9

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
            420                 425                 430         


Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
        435                 440                 445             


Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
    450                 455                 460                 


Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
465                 470                 475                 480 


Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                485                 490                 495     


Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
            500                 505                 510         


Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
        515                 520                 525             


Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
    530                 535                 540                 


Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
545                 550                 555                 560 


Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                565                 570                 575     


Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
            580                 585                 590         


Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
        595                 600                 605             


Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
    610                 615                 620                 


Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
625                 630                 635                 640 


Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                645                 650                 655     


Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
            660                 665                 670         


Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
        675                 680                 685             


Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val 
    690                 695                 700                 


Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
705                 710                 715                 720 


Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                725                 730                 735     


Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
            740                 745                 750         


Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
        755                 760                 765             


Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg 
    770                 775                 780                 


Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
785                 790                 795                 800 


Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn 
                805                 810                 815     


Gly Gly Leu Lys Arg Arg 
            820         


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer for Egr1

<400>  10
gaggagatga tgctgctgag                                                   20


<210>  11
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer for Egr1

<400>  11
tgctgctgct gctattacc                                                    19


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer for cyclophilin

<400>  12
gtctcttttc gccgcttgct                                                   20


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer for cyclophilin

<400>  13
tctgctgtct ttggaacttt gtctg                                             25


<210>  14
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR1b portion

<400>  14

Asp Pro Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn Gly 
1               5                   10                  15      


Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys His 
            20                  25                  30          


Ser Gly Ile Asn Ser Ser Asp Ala Glu Val Leu Thr Leu Phe Asn Val 
        35                  40                  45              


Thr Glu Ala Gln Ser Gly Glu Tyr Val Cys Lys Val Ser Asn Tyr Ile 
    50                  55                  60                  


Gly Glu Ala Asn Gln Ser Ala Trp Leu Thr Val Thr Arg Pro Ala 
65                  70                  75                  


<210>  15
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR1c portion

<400>  15

Asp Pro Gln Pro His Ile Gln Trp Leu Lys His Ile Glu Val Asn Gly 
1               5                   10                  15      


Ser Lys Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys Thr 
            20                  25                  30          


Ala Gly Val Asn Thr Thr Asp Lys Glu Met Glu Val Leu His Leu Arg 
        35                  40                  45              


Asn Val Ser Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn 
    50                  55                  60                  


Ser Ile Gly Leu Ser His His Ser Ala Trp Leu Thr Val Leu Glu Ala 
65                  70                  75                  80  


<210>  16
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR2b portion

<400>  16

Asp Ala Gln Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn Gly 
1               5                   10                  15      


Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys His 
            20                  25                  30          


Ser Gly Ile Asn Ser Ser Asn Ala Glu Val Leu Ala Leu Phe Asn Val 
        35                  40                  45              


Thr Glu Ala Asp Ala Gly Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile 
    50                  55                  60                  


Gly Gln Ala Asn Gln Ser Ala Trp Leu Thr Val Leu Pro Lys Gln 
65                  70                  75                  


<210>  17
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR2c portion

<400>  17

Asp Ala Gln Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn Gly 
1               5                   10                  15      


Ser Lys Tyr Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala 
            20                  25                  30          


Ala Gly Val Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg 
        35                  40                  45              


Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn 
    50                  55                  60                  


Ser Ile Gly Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro 
65                  70                  75                  


<210>  18
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR3b portion

<400>  18

Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly 
1               5                   10                  15      


Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Ser 
            20                  25                  30          


Trp Ile Ser Glu Ser Val Glu Ala Asp Val Arg Leu Arg Leu Ala Asn 
        35                  40                  45              


Val Ser Glu Arg Asp Gly Gly Glu Tyr Leu Cys Arg Ala Thr Asn Phe 
    50                  55                  60                  


Ile Gly Val Ala Glu Lys Ala Phe Trp Leu Ser Val His Gly Pro Arg 
65                  70                  75                  80  


<210>  19
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR3c portion

<400>  19

Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly 
1               5                   10                  15      


Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Thr 
            20                  25                  30          


Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu His 
        35                  40                  45              


Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn 
    50                  55                  60                  


Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu 
65                  70                  75              


<210>  20
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGFR4 portion

<400>  20

Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly 
1               5                   10                  15      


Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr 
            20                  25                  30          


Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val 
        35                  40                  45              


Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile 
    50                  55                  60                  


Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Glu 
65                  70                  75                  


<210>  21
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Klotho Related Protein KLrP

<400>  21

Met Ala Phe Pro Ala Gly Phe Gly Trp Ala Ala Ala Thr Ala Ala Tyr 
1               5                   10                  15      


Gln Val Glu Gly Gly Trp Asp Ala Asp Gly Lys Gly Pro Cys Val Trp 
            20                  25                  30          


Asp Thr Phe Thr His Gln Gly Gly Glu Arg Val Phe Lys Asn Gln Thr 
        35                  40                  45              


Gly Asp Val Ala Cys Gly Ser Tyr Thr Leu Trp Glu Glu Asp Leu Lys 
    50                  55                  60                  


Cys Ile Lys Gln Leu Gly Leu Thr His Tyr Arg Phe Ser Leu Ser Trp 
65                  70                  75                  80  


Ser Arg Leu Leu Pro Asp Gly Thr Thr Gly Phe Ile Asn Gln Lys Gly 
                85                  90                  95      


Ile Asp Tyr Tyr Asn Lys Ile Ile Asp Asp Leu Leu Lys Asn Gly Val 
            100                 105                 110         


Thr Pro Ile Val Thr Leu Tyr His Phe Asp Leu Pro Gln Thr Leu Glu 
        115                 120                 125             


Asp Gln Gly Gly Trp Leu Ser Glu Ala Ile Ile Glu Ser Phe Asp Lys 
    130                 135                 140                 


Tyr Ala Gln Phe Cys Phe Ser Thr Phe Gly Asp Arg Val Lys Gln Trp 
145                 150                 155                 160 


Ile Thr Ile Asn Glu Ala Asn Val Leu Ser Val Met Ser Tyr Asp Leu 
                165                 170                 175     


Gly Met Phe Pro Pro Gly Ile Pro His Phe Gly Thr Gly Gly Tyr Gln 
            180                 185                 190         


Ala Ala His Asn Leu Ile Lys Ala His Ala Arg Ser Trp His Ser Tyr 
        195                 200                 205             


Asp Ser Leu Phe Arg Lys Lys Gln Lys Gly Met Val Ser Leu Ser Leu 
    210                 215                 220                 


Phe Ala Val Trp Leu Glu Pro Ala Asp Pro Asn Ser Val Ser Asp Gln 
225                 230                 235                 240 


Glu Ala Ala Lys Arg Ala Ile Thr Phe His Leu Asp Leu Phe Ala Lys 
                245                 250                 255     


Pro Ile Phe Ile Asp Gly Asp Tyr Pro Glu Val Val Lys Ser Gln Ile 
            260                 265                 270         


Ala Ser Met Ser Gln Lys Gln Gly Tyr Pro Ser Ser Arg Leu Pro Glu 
        275                 280                 285             


Phe Thr Glu Glu Glu Lys Lys Met Ile Lys Gly Thr Ala Asp Phe Phe 
    290                 295                 300                 


Ala Val Gln Tyr Tyr Thr Thr Arg Leu Ile Lys Tyr Gln Glu Asn Lys 
305                 310                 315                 320 


Lys Gly Glu Leu Gly Ile Leu Gln Asp Ala Glu Ile Glu Phe Phe Pro 
                325                 330                 335     


Asp Pro Ser Trp Lys Asn Val Asp Trp Ile Tyr Val Val Pro Trp Gly 
            340                 345                 350         


Val Cys Lys Leu Leu Lys Tyr Ile Lys Asp Thr Tyr Asn Asn Pro Val 
        355                 360                 365             


Ile Tyr Ile Thr Glu Asn Gly Phe Pro Gln Ser Asp Pro Ala Pro Leu 
    370                 375                 380                 


Asp Asp Thr Gln Arg Trp Glu Tyr Phe Arg Gln Thr Phe Gln Glu Leu 
385                 390                 395                 400 


Phe Lys Ala Ile Gln Leu Asp Lys Val Asn Leu Gln Val Tyr Cys Ala 
                405                 410                 415     


Trp Ser Leu Leu Asp Asn Phe Glu Trp Asn Gln Gly Tyr Ser Ser Arg 
            420                 425                 430         


Phe Gly Leu Phe His Val Asp Phe Glu Asp Pro Ala Arg Pro Arg Val 
        435                 440                 445             


Pro Tyr Thr Ser Ala Lys Glu Tyr Ala Lys Ile Ile Arg Asn Asn Gly 
    450                 455                 460                 


Leu Glu Ala His Leu 
465                 


<210>  22
<211>  1012
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-Klotho

<400>  22

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys 
    1010         


<210>  23
<211>  1044
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta-Klotho

<400>  23

Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe 
1               5                   10                  15      


Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met Ser Asn 
            20                  25                  30          


Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile Leu Leu Arg 
        35                  40                  45              


Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn 
    50                  55                  60                  


Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr 
65                  70                  75                  80  


Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val 
                85                  90                  95      


Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His 
            100                 105                 110         


Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser 
        115                 120                 125             


Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile 
    130                 135                 140                 


Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro 
145                 150                 155                 160 


Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser 
                165                 170                 175     


Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly 
        195                 200                 205             


Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr 
    210                 215                 220                 


Cys Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His 
225                 230                 235                 240 


Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala 
                245                 250                 255     


Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn 
            260                 265                 270         


Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe 
        275                 280                 285             


Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp 
    290                 295                 300                 


Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln 
305                 310                 315                 320 


Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly 
                325                 330                 335     


Asp Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu 
            340                 345                 350         


Pro Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp 
        355                 360                 365             


Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr 
    370                 375                 380                 


Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu 
385                 390                 395                 400 


Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu 
                405                 410                 415     


Asn Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala 
            420                 425                 430         


Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg 
        435                 440                 445             


Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp 
    450                 455                 460                 


Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala 
                485                 490                 495     


His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu 
            500                 505                 510         


Ser Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly 
        515                 520                 525             


Val Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln 
    530                 535                 540                 


Phe Ser Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu 
545                 550                 555                 560 


Leu His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys 
                565                 570                 575     


Thr Asp Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met 
            580                 585                 590         


Lys Val Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro 
        595                 600                 605             


Thr Gly Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg 
    610                 615                 620                 


Cys Val Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr 
625                 630                 635                 640 


Leu Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu 
                645                 650                 655     


His Ala Asp Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala 
            660                 665                 670         


Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp 
        675                 680                 685             


Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser 
    690                 695                 700                 


Gly Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala 
705                 710                 715                 720 


Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly 
                725                 730                 735     


Ala Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro 
            740                 745                 750         


Tyr Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu 
        755                 760                 765             


Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala 
    770                 775                 780                 


Ala Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser 
785                 790                 795                 800 


Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly 
                805                 810                 815     


Thr Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met 
            820                 825                 830         


His Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln 
        835                 840                 845             


Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val 
    850                 855                 860                 


Ile Pro Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr 
865                 870                 875                 880 


Gly Asp Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala 
                885                 890                 895     


Leu Glu Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln 
            900                 905                 910         


Glu Val Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr 
        915                 920                 925             


Tyr Ala Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe 
    930                 935                 940                 


Phe Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys 
945                 950                 955                 960 


Val Ile Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys 
                965                 970                 975     


Ser Gln Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val 
            980                 985                 990         


Gln Lys Lys Pro Leu Ile Phe Leu  Gly Cys Cys Phe Phe  Ser Thr Leu 
        995                 1000                 1005             


Val Leu  Leu Leu Ser Ile Ala  Ile Phe Gln Arg Gln  Lys Arg Arg 
    1010                 1015                 1020             


Lys Phe  Trp Lys Ala Lys Asn  Leu Gln His Ile Pro  Leu Lys Lys 
    1025                 1030                 1035             


Gly Lys  Arg Val Val Ser 
    1040                 


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Unrelated sequence

<400>  24

Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr Lys Pro Tyr His 
1               5                   10                  15      


<210>  25
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF23 portion

<400>  25

Tyr Pro Asn Ala Ser Pro Leu Leu Gly Ser Ser Trp Gly Gly Leu Ile 
1               5                   10                  15      


His Leu Tyr Thr Ala Thr Ala Arg Asn Ser Tyr His Leu Gln Ile His 
            20                  25                  30          


Lys Asn Gly His Val Asp Gly Ala Pro His Gln Thr Ile Tyr Ser Ala 
        35                  40                  45              


Leu Met Ile Arg Ser Glu Asp Ala Gly Phe Val Val Ile Thr Gly Val 
    50                  55                  60                  


Met Ser Arg Arg Tyr Leu Cys Met Asp Phe Arg Gly Asn Ile Phe Gly 
65                  70                  75                  80  


Ser His Tyr Phe Asp Pro Glu Asn Cys Arg Phe Gln His Gln Thr Leu 
                85                  90                  95      


Glu Asn Gly Tyr Asp Val Tyr His Ser Pro Gln Tyr His Phe Leu Val 
            100                 105                 110         


Ser Leu Gly Arg Ala Lys Arg Ala Phe Leu Pro Gly Met Asn Pro Pro 
        115                 120                 125             


Pro Tyr Ser Gln Phe Leu Ser Arg Arg Asn Glu Ile Pro Leu Ile His 
    130                 135                 140                 


Phe Asn Thr Pro Ile Pro Arg Arg His Thr Arg Ser Ala Glu Asp Asp 
145                 150                 155                 160 


Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met Thr 
                165                 170                 175     


Pro Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro Ser Ala Glu Asp Asn 
            180                 185                 190         


Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val Arg Gly Gly Arg Val 
        195                 200                 205             


Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly Cys Arg Pro Phe Ala 
    210                 215                 220                 


Lys Phe Ile 
225         


<210>  26
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF21 portion

<400>  26

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser 
            180     


<210>  27
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FGF19

<400>  27

Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
1               5                   10                  15      


Gly Asp Pro Ile Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly 
            20                  25                  30          


Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys 
        35                  40                  45              


Ala Arg Gly Gln Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala 
    50                  55                  60                  


Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys 
65                  70                  75                  80  


Met Gly Ala Asp Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu 
                85                  90                  95      


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            100                 105                 110         


Arg Ser Glu Lys His Arg Leu Pro Val Ser Leu Ser Ser Ala Lys Gln 
        115                 120                 125             


Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    130                 135                 140                 


Pro Met Leu Pro Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His 
145                 150                 155                 160 


Leu Glu Ser Asp Met Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp 
                165                 170                 175     


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
            180                 185                 190         


Glu Lys 
        


<210>  28
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule encoding alpha-Klotho receptor binding arm

<400>  28
aactacattc aagtagatac cactctgtct cagtttaccg acctgaatgt ttacctgtgg       60

gatgtccacc acagtaaaag gcttattaaa gtggatgggg ttgtgaccaa gaagaggaaa      120

tcctactgtg ttgactttgc tgccatc                                          147


<210>  29
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of RBA deleted

<400>  29
ctgaatgttt acctgtggga tgtccaccac agtaaaaggc ttattaaagt ggatggggtt       60

gtgacc                                                                  66


