                         SEQUENCE LISTING

<110>  Oxford Genetics Limited
 
<120>  Vectors

<130>  489.412.135819/01

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  1866
<212>  DNA
<213>  adeno-associated virus 2

<400>  1
atgccggggt tttacgagat tgtgattaag gtccccagcg accttgacga gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggccct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccgcggga tcgagccgac tttgccaaac tggttcgcgg tcacaaagac cagaaatggc      420

gccggaggcg ggaacaaggt ggtggatgag tgctacatcc ccaattactt gctccccaaa      480

acccagcctg agctccagtg ggcgtggact aatatggaac agtatttaag cgcctgtttg      540

aatctcacgg agcgtaaacg gttggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aagagaatca gaatcccaat tctgatgcgc cggtgatcag atcaaaaact      660

tcagccaggt acatggagct ggtcgggtgg ctcgtggaca aggggattac ctcggagaag      720

cagtggatcc aggaggacca ggcctcatac atctccttca atgcggcctc caactcgcgg      780

tcccaaatca aggctgcctt ggacaatgcg ggaaagatta tgagcctgac taaaaccgcc      840

cccgactacc tggtgggcca gcagcccgtg gaggacattt ccagcaatcg gatttataaa      900

attttggaac taaacgggta cgatccccaa tatgcggctt ccgtctttct gggatgggcc      960

acgaaaaagt tcggcaagag gaacaccatc tggctgtttg ggcctgcaac taccgggaag     1020

accaacatcg cggaggccat agcccacact gtgcccttct acgggtgcgt aaactggacc     1080

aatgagaact ttcccttcaa cgactgtgtc gacaagatgg tgatctggtg ggaggagggg     1140

aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc tcggaggaag caaggtgcgc     1200

gtggaccaga aatgcaagtc ctcggcccag atagacccga ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgccgt gattgacggg aactcaacga ccttcgaaca ccagcagccg     1320

ttgcaagacc ggatgttcaa atttgaactc acccgccgtc tggatcatga ctttgggaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcaa aggatcacgt ggttgaggtg     1440

gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa gacccgcccc cagtgacgca     1500

gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc agccatcgac gtcagacgcg     1560

gaagcttcga tcaactacgc agacaggtac caaaacaaat gttctcgtca cgtgggcatg     1620

aatctgatgc tgtttccctg cagacaatgc gagagaatga atcagaattc aaatatctgc     1680

ttcactcacg gacagaaaga ctgtttagag tgctttcccg tgtcagaatc tcaacccgtt     1740

tctgtcgtca aaaaggcgta tcagaaactg tgctacattc atcatatcat gggaaaggtg     1800

ccagacgctt gcactgcctg cgatctggtc aatgtggatt tggatgactg catctttgaa     1860

caatag                                                                1866


<210>  2
<211>  621
<212>  PRT
<213>  adeno-associated virus 2

<400>  2

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Gly His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  3
<211>  528
<212>  PRT
<213>  adeno-associated virus 2

<400>  3

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


<210>  4
<211>  397
<212>  PRT
<213>  adeno-associated virus 2

<400>  4

Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
1               5                   10                  15      


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
            20                  25                  30          


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
        35                  40                  45              


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
    50                  55                  60                  


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
65                  70                  75                  80  


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
                85                  90                  95      


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
            100                 105                 110         


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
        115                 120                 125             


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
    130                 135                 140                 


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
145                 150                 155                 160 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
                165                 170                 175     


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
            180                 185                 190         


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
        195                 200                 205             


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
    210                 215                 220                 


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
225                 230                 235                 240 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
                245                 250                 255     


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
            260                 265                 270         


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
        275                 280                 285             


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
    290                 295                 300                 


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
305                 310                 315                 320 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
                325                 330                 335     


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
            340                 345                 350         


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
        355                 360                 365             


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
    370                 375                 380                 


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
385                 390                 395         


<210>  5
<211>  312
<212>  PRT
<213>  adeno-associated virus 2

<400>  5

Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
1               5                   10                  15      


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
            20                  25                  30          


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
        35                  40                  45              


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
    50                  55                  60                  


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
65                  70                  75                  80  


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
                85                  90                  95      


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
            100                 105                 110         


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
        115                 120                 125             


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
    130                 135                 140                 


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
145                 150                 155                 160 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
                165                 170                 175     


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
            180                 185                 190         


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
        195                 200                 205             


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
    210                 215                 220                 


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
225                 230                 235                 240 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
                245                 250                 255     


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
            260                 265                 270         


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
        275                 280                 285             


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
    290                 295                 300                 


Arg Leu Ala Arg Gly His Ser Leu 
305                 310         


<210>  6
<211>  1866
<212>  DNA
<213>  adeno-associated virus 2

<400>  6
atgccggggt tttacgagat tgtgattaag gtccccagcg accttgacgg gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggccct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccgcggga tcgagccgac tttgccaaac tggttcgcgg tcacaaagac cagaaatggc      420

gccggaggcg ggaacaaggt ggtggatgag tgctacatcc ccaattactt gctccccaaa      480

acccagcctg agctccagtg ggcgtggact aatatggaac agtacctcag cgcctgtttg      540

aatctcacgg agcgtaaacg gttggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aagagaatca gaatcccaat tctgatgcgc cggtgatcag atcaaaaact      660

tcagccaggt acatggagct ggtcgggtgg ctcgtggaca aggggattac ctcggagaag      720

cagtggatcc aggaggacca ggcctcatac atctccttca atgcggcctc caactcgcgg      780

tcccaaatca aggctgcctt ggacaatgcg ggaaagatta tgagcctgac taaaaccgcc      840

cccgactacc tggtgggcca gcagcccgtg gaggacattt ccagcaatcg gatttataaa      900

attttggaac taaacgggta cgatccccaa tatgcggctt ccgtctttct gggatgggcc      960

acgaaaaagt tcggcaagag gaacaccatc tggctgtttg ggcctgcaac taccgggaag     1020

accaacatcg cggaggccat agcccacact gtgcccttct acgggtgcgt aaactggacc     1080

aatgagaact ttcccttcaa cgactgtgtc gacaagatgg tgatctggtg ggaggagggg     1140

aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc tcggaggaag caaggtgcgc     1200

gtggaccaga aatgcaagtc ctcggcccag atagacccga ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgccgt gattgacggg aactcaacga ccttcgaaca ccagcagccg     1320

ttgcaagacc ggatgttcaa atttgaactc acccgccgtc tggatcatga ctttgggaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcaa aggatcacgt ggttgaggtg     1440

gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa gacccgcccc cagtgacgca     1500

gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc agccatcgac gtcagacgcg     1560

gaagcttcga tcaactacgc agacaggtac caaaacaaat gttctcgtca cgtgggcatg     1620

aatctgatgc tgtttccctg cagacaatgc gagagaatga atcagaattc aaatatctgc     1680

ttcactcacg gacagaaaga ctgtttagag tgctttcccg tgtcagaatc tcaacccgtt     1740

tctgtcgtca aaaaggcgta tcagaaactg tgctacattc atcatatcat gggaaaggtg     1800

ccagacgctt gcactgcctg cgatctggtc aatgtggatt tggatgactg catctttgaa     1860

caatag                                                                1866


<210>  7
<211>  1589
<212>  DNA
<213>  adeno-associated virus 2

<400>  7
atgccggggt tttacgagat tgtgattaag gtccccagcg accttgacga gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggccct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccgcggga tcgagccgac tttgccaaac tggttcgcgg tcacaaagac cagaaatggc      420

gccggaggcg ggaacaaggt ggtggatgag tgctacatcc ccaattactt gctccccaaa      480

acccagcctg agctccagtg ggcgtggact aatatggaac agtacctcag cgcctgtttg      540

aatctcacgg agcgtaaacg gttggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aagagaatca gaatcccaat tctgatgcgc cggtgatcag atcaaaaact      660

tcagccaggt acatggagct ggtcgggtgg ctcgtggaca aggggattac ctcggagaag      720

cagtggatcc aggaggacca ggcctcatac atctccttca atgcggcctc caactcgcgg      780

tcccaaatca aggctgcctt ggacaatgcg ggaaagatta tgagcctgac taaaaccgcc      840

cccgactacc tggtgggcca gcagcccgtg gaggacattt ccagcaatcg gatttataaa      900

attttggaac taaacgggta cgatccccaa tatgcggctt ccgtctttct gggatgggcc      960

acgaaaaagt tcggcaagag gaacaccatc tggctgtttg ggcctgcaac taccgggaag     1020

accaacatcg cggaggccat agcccacact gtgcccttct acgggtgcgt aaactggacc     1080

aatgagaact ttcccttcaa cgactgtgtc gacaagatgg tgatctggtg ggaggagggg     1140

aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc tcggaggaag caaggtgcgc     1200

gtggaccaga aatgcaagtc ctcggcccag atagacccga ctcccgtgat cgtcacctcc     1260

aacaccaaca tgtgcgccgt gattgacggg aactcaacga ccttcgaaca ccagcagccg     1320

ttgcaagacc ggatgttcaa atttgaactc acccgccgtc tggatcatga ctttgggaag     1380

gtcaccaagc aggaagtcaa agactttttc cggtgggcaa aggatcacgt ggttgaggtg     1440

gagcatgaat tctacgtcaa aaagggtgga gccaagaaaa gacccgcccc cagtgacgca     1500

gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc agccatcgac gtcagacgcg     1560

gaagcttcga tcaactacgc agacagtag                                       1589


<210>  8
<211>  1195
<212>  DNA
<213>  adeno-associated virus 2

<400>  8
catggagctg gtcgggtggc tcgtggacaa ggggattacc tcggagaagc agtggatcca       60

ggaggaccag gcctcataca tctccttcaa tgcggcctcc aactcgcggt cccaaatcaa      120

ggctgccttg gacaatgcgg gaaagattat gagcctgact aaaaccgccc ccgactacct      180

ggtgggccag cagcccgtgg aggacatttc cagcaatcgg atttataaaa ttttggaact      240

aaacgggtac gatccccaat atgcggcttc cgtctttctg ggatgggcca cgaaaaagtt      300

cggcaagagg aacaccatct ggctgtttgg gcctgcaact accgggaaga ccaacatcgc      360

ggaggccata gcccacactg tgcccttcta cgggtgcgta aactggacca atgagaactt      420

tcccttcaac gactgtgtcg acaagatggt gatctggtgg gaggagggga agatgaccgc      480

caaggtcgtg gagtcggcca aagccattct cggaggaagc aaggtgcgcg tggaccagaa      540

atgcaagtcc tcggcccaga tagacccgac tcccgtgatc gtcacctcca acaccaacat      600

gtgcgccgtg attgacggga actcaacgac cttcgaacac cagcagccgt tgcaagaccg      660

gatgttcaaa tttgaactca cccgccgtct ggatcatgac tttgggaagg tcaccaagca      720

ggaagtcaaa gactttttcc ggtgggcaaa ggatcacgtg gttgaggtgg agcatgaatt      780

ctacgtcaaa aagggtggag ccaagaaaag acccgccccc agtgacgcag atataagtga      840

gcccaaacgg gtgcgcgagt cagttgcgca gccatcgacg tcagacgcgg aagcttcgat      900

caactacgca gacaggtacc aaaacaaatg ttctcgtcac gtgggcatga atctgatgct      960

gtttccctgc agacaatgcg agagaatgaa tcagaattca aatatctgct tcactcacgg     1020

acagaaagac tgtttagagt gctttcccgt gtcagaatct caacccgttt ctgtcgtcaa     1080

aaaggcgtat cagaaactgt gctacattca tcatatcatg ggaaaggtgc cagacgcttg     1140

cactgcctgc gatctggtca atgtggattt ggatgactgc atctttgaac aatag          1195


<210>  9
<211>  939
<212>  DNA
<213>  adeno-associated virus 2

<400>  9
atggagctgg tcgggtggct cgtggacaag gggattacct cggagaagca gtggatccag       60

gaggaccagg cctcatacat ctccttcaat gcggcctcca actcgcggtc ccaaatcaag      120

gctgccttgg acaatgcggg aaagattatg agcctgacta aaaccgcccc cgactacctg      180

gtgggccagc agcccgtgga ggacatttcc agcaatcgga tttataaaat tttggaacta      240

aacgggtacg atccccaata tgcggcttcc gtctttctgg gatgggccac gaaaaagttc      300

ggcaagagga acaccatctg gctgtttggg cctgcaacta ccgggaagac caacatcgcg      360

gaggccatag cccacactgt gcccttctac gggtgcgtaa actggaccaa tgagaacttt      420

cccttcaacg actgtgtcga caagatggtg atctggtggg aggaggggaa gatgaccgcc      480

aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgcgt ggaccagaaa      540

tgcaagtcct cggcccagat agacccgact cccgtgatcg tcacctccaa caccaacatg      600

tgcgccgtga ttgacgggaa ctcaacgacc ttcgaacacc agcagccgtt gcaagaccgg      660

atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt caccaagcag      720

gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgaattc      780

tacgtcaaaa agggtggagc caagaaaaga cccgccccca gtgacgcaga tataagtgag      840

cccaaacggg tgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc      900

aactacgcag acagattggc tcgaggacac tctctctag                             939


<210>  10
<211>  2559
<212>  DNA
<213>  adeno-associated virus 2

<400>  10
cagttgcgca gccatcgacg tcagacgcgg aagcttcgat caactacgca gacaggtacc       60

aaaacaaatg ttctcgtcac gtgggcatga atctgatgct gtttccctgc agacaatgcg      120

agagaatgaa tcagaattca aatatctgct tcactcacgg acagaaagac tgtttagagt      180

gctttcccgt gtcagaatct caacccgttt ctgtcgtcaa aaaggcgtat cagaaactgt      240

gctacattca tcatatcatg ggaaaggtgc cagacgcttg cactgcctgc gatctggtca      300

atgtggattt ggatgactgc atctttgaac aataaatgat ttaaatcagg tatggctgcc      360

gatggttatc ttccagattg gctcgaggac actctctctg aaggaataag acagtggtgg      420

aagctcaaac ctggcccacc accaccaaag cccgcagagc ggcataagga cgacagcagg      480

ggtcttgtgc ttcctgggta caagtacctc ggacccttca acggactcga caagggagag      540

ccggtcaacg aggcagacgc cgcggccctc gagcacgaca aagcctacga ccggcagctc      600

gacagcggag acaacccgta cctcaagtac aaccacgccg acgcggagtt tcaggagcgc      660

cttaaagaag atacgtcttt tgggggcaac ctcggacgag cagtcttcca ggcgaaaaag      720

agggttcttg aacctctggg cctggttgag gaacctgtta agacggctcc gggaaaaaag      780

aggccggtag agcactctcc tgtggagcca gactcctcct cgggaaccgg aaaggcgggc      840

cagcagcctg caagaaaaag attgaatttt ggtcagactg gagacgcaga ctcagtacct      900

gacccccagc ctctcggaca gccaccagca gccccctctg gtctgggaac taatacgatg      960

gctacaggca gtggcgcacc aatggcagac aataacgagg gcgccgacgg agtgggtaat     1020

tcctcgggaa attggcattg cgattccaca tggatgggcg acagagtcat caccaccagc     1080

acccgaacct gggccctgcc cacctacaac aaccacctct acaaacaaat ttccagccaa     1140

tcaggagcct cgaacgacaa tcactacttt ggctacagca ccccttgggg gtattttgac     1200

ttcaacagat tccactgcca cttttcacca cgtgactggc aaagactcat caacaacaac     1260

tggggattcc gacccaagag actcaacttc aagctcttta acattcaagt caaagaggtc     1320

acgcagaatg acggtacgac gacgattgcc aataacctta ccagcacggt tcaggtgttt     1380

actgactcgg agtaccagct cccgtacgtc ctcggctcgg cgcatcaagg atgcctcccg     1440

ccgttcccag cagacgtctt catggtgcca cagtatggat acctcaccct gaacaacggg     1500

agtcaggcag taggacgctc ttcattttac tgcctggagt actttccttc tcagatgctg     1560

cgtaccggaa acaactttac cttcagctac acttttgagg acgttccttt ccacagcagc     1620

tacgctcaca gccagagtct ggaccgtctc atgaatcctc tcatcgacca gtacctgtat     1680

tacttgagca gaacaaacac tccaagtgga accaccacgc agtcaaggct tcagttttct     1740

caggccggag cgagtgacat tcgggaccag tctaggaact ggcttcctgg accctgttac     1800

cgccagcagc gagtatcaaa gacatctgcg gataacaaca acagtgaata ctcgtggact     1860

ggagctacca agtaccacct caatggcaga gactctctgg tgaatccggg cccggccatg     1920

gcaagccaca aggacgatga agaaaagttt tttcctcaga gcggggttct catctttggg     1980

aagcaaggct cagagaaaac aaatgtggac attgaaaagg tcatgattac agacgaagag     2040

gaaatcagga caaccaatcc cgtggctacg gagcagtatg gttctgtatc taccaacctc     2100

cagagaggca acagacaagc agctaccgca gatgtcaaca cacaaggcgt tcttccaggc     2160

atggtctggc aggacagaga tgtgtacctt caggggccca tctgggcaaa gattccacac     2220

acggacggac attttcaccc ctctcccctc atgggtggat tcggacttaa acaccctcct     2280

ccacagattc tcatcaagaa caccccggta cctgcgaatc cttcgaccac cttcagtgcg     2340

gcaaagtttg cttccttcat cacacagtac tccacgggac aggtcagcgt ggagatcgag     2400

tgggagctgc agaaggaaaa cagcaaacgc tggaatcccg aaattcagta cacttccaac     2460

tacaacaagt ctgttaatgt ggactttact gtggacacta atggcgtgta ttcagagcct     2520

cgccccattg gcaccagata cctgactcgt aatctgtaa                            2559


<210>  11
<211>  735
<212>  PRT
<213>  adeno-associated virus 2

<400>  11

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TetR binding site

<400>  12
tccctatcag tgatagaga                                                    19


<210>  13
<211>  624
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of the TetR protein

<400>  13
atgtcgcgcc tggacaaaag caaagtgatt aactcagcgc tggaactgtt gaatgaggtg       60

ggaattgaag gactcactac tcgcaagctg gcacagaagc tgggcgtcga gcagccaacg      120

ctgtactggc atgtgaagaa taaacgggcg ctcctagacg cgcttgccat cgaaatgctg      180

gaccgccatc acacccactt ttgccccctg gagggcgaat cctggcaaga ttttctgcgg      240

aacaatgcaa agtcgttccg gtgcgctctg ctgtcccacc gcgatggcgc aaaagtgcac      300

ctgggcactc ggcccaccga gaaacaatac gaaaccctgg aaaaccaact ggctttcctt      360

tgccaacagg gattttcact ggagaatgcc ctgtacgcac tatccgcggt cggccacttt      420

accctgggat gcgtcctcga agatcaggag caccaagtcg ccaaggagga aagagaaact      480

cctaccactg actcaatgcc tccgctcctg agacaagcca tcgagctgtt cgaccaccag      540

ggtgctgaac ctgcatttct gttcgggctt gaactgatta tctgcggcct ggagaaacag      600

ttgaagtgcg agtcgggatc ctag                                             624


<210>  14
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the TetR protein

<400>  14

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser 
        195                 200                 205         


<210>  15
<211>  519
<212>  DNA
<213>  Encephalomyocarditis virus

<400>  15
cgttactggc cgaagccgct tggaataagg ccggtgtgcg tttgtctata tgttattttc       60

caccatattg ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg tcttcttgac      120

gagcattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt      180

gaaggaagca gttcctctgg aagcttcttg aagacaaaca acgtctgtag cgaccctttg      240

caggcagcgg aaccccccac ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata      300

agatacacct gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga tagttgtgga      360

aagagtcaaa tggctcccct caagcgtatt caacaagggg ctgaaggatg cccagaaggt      420

accccattgt atgggatctg atctggggcc tcggtgcaca tgctttacat gtgtttagtc      480

gaggttaaaa aacgtctagg ccccccgaac cacggggac                             519


<210>  16
<211>  461
<212>  DNA
<213>  Foot-and-mouth disease virus

<400>  16
agcaggtttc cccaactgac acaaaacgtg caacttgaaa ctccgcctgg tctttccagg       60

tctagagggg taacactttg tactgcgttt ggctccacgc tcgatccact ggcgagtgtt      120

agtaacagca ctgttgcttc gtagcggagc atgacggccg tgggaactcc tccttggtaa      180

caaggaccca cggggccaaa agccacgccc acacgggccc gtcatgtgtg caaccccagc      240

acggcgactt tactgcgaaa cccactttaa agtgacattg aaactggtac ccacacactg      300

gtgacaggct aaggatgccc ttcaggtacc ccgaggtaac acgcgacact cgggatctga      360

gaaggggact ggggcttcta taaaagcgct cggtttaaaa agcttctatg cctgaatagg      420

tgaccggagg tcggcacctt tcctttgcaa ttactgacca c                          461


<210>  17
<211>  5341
<212>  DNA
<213>  Human adenovirus type 5

<400>  17
ggtacccaac tccatgctca acagtcccca ggtacagccc accctgcgtc gcaaccagga       60

acagctctac agcttcctgg agcgccactc gccctacttc cgcagccaca gtgcgcagat      120

taggagcgcc acttcttttt gtcacttgaa aaacatgtaa aaataatgta ctagagacac      180

tttcaataaa ggcaaatgct tttatttgta cactctcggg tgattattta cccccaccct      240

tgccgtctgc gccgtttaaa aatcaaaggg gttctgccgc gcatcgctat gcgccactgg      300

cagggacacg ttgcgatact ggtgtttagt gctccactta aactcaggca caaccatccg      360

cggcagctcg gtgaagtttt cactccacag gctgcgcacc atcaccaacg cgtttagcag      420

gtcgggcgcc gatatcttga agtcgcagtt ggggcctccg ccctgcgcgc gcgagttgcg      480

atacacaggg ttgcagcact ggaacactat cagcgccggg tggtgcacgc tggccagcac      540

gctcttgtcg gagatcagat ccgcgtccag gtcctccgcg ttgctcaggg cgaacggagt      600

caactttggt agctgccttc ccaaaaaggg cgcgtgccca ggctttgagt tgcactcgca      660

ccgtagtggc atcaaaaggt gaccgtgccc ggtctgggcg ttaggataca gcgcctgcat      720

aaaagccttg atctgcttaa aagccacctg agcctttgcg ccttcagaga agaacatgcc      780

gcaagacttg ccggaaaact gattggccgg acaggccgcg tcgtgcacgc agcaccttgc      840

gtcggtgttg gagatctgca ccacatttcg gccccaccgg ttcttcacga tcttggcctt      900

gctagactgc tccttcagcg cgcgctgccc gttttcgctc gtcacatcca tttcaatcac      960

gtgctcctta tttatcataa tgcttccgtg tagacactta agctcgcctt cgatctcagc     1020

gcagcggtgc agccacaacg cgcagcccgt gggctcgtga tgcttgtagg tcacctctgc     1080

aaacgactgc aggtacgcct gcaggaatcg ccccatcatc gtcacaaagg tcttgttgct     1140

ggtgaaggtc agctgcaacc cgcggtgctc ctcgttcagc caggtcttgc atacggccgc     1200

cagagcttcc acttggtcag gcagtagttt gaagttcgcc tttagatcgt tatccacgtg     1260

gtacttgtcc atcagcgcgc gcgcagcctc catgcccttc tcccacgcag acacgatcgg     1320

cacactcagc gggttcatca ccgtaatttc actttccgct tcgctgggct cttcctcttc     1380

ctcttgcgtc cgcataccac gcgccactgg gtcgtcttca ttcagccgcc gcactgtgcg     1440

cttacctcct ttgccatgct tgattagcac cggtgggttg ctgaaaccca ccatttgtag     1500

cgccacatct tctctttctt cctcgctgtc cacgattacc tctggtgatg gcgggcgctc     1560

gggcttggga gaagggcgct tctttttctt cttgggcgca atggccaaat ccgccgccga     1620

ggtcgatggc cgcgggctgg gtgtgcgcgg caccagcgcg tcttgtgatg agtcttcctc     1680

gtcctcggac tcgatacgcc gcctcatccg cttttttggg ggcgcccggg gaggcggcgg     1740

cgacggggac ggggacgaca cgtcctccat ggttggggga cgtcgcgccg caccgcgtcc     1800

gcgctcgggg gtggtttcgc gctgctcctc ttcccgactg gccatttcct tctcctatag     1860

gcagaaaaag atcatggagt cagtcgagaa gaaggacagc ctaaccgccc cctctgagtt     1920

cgccaccacc gcctccaccg atgccgccaa cgcgcctacc accttccccg tcgaggcacc     1980

cccgcttgag gaggaggaag tgattatcga gcaggaccca ggttttgtaa gcgaagacga     2040

cgaggaccgc tcagtaccaa cagaggataa aaagcaagac caggacaacg cagaggcaaa     2100

cgaggaacaa gtcgggcggg gggacgaaag gcatggcgac tacctagatg tgggagacga     2160

cgtgctgttg aagcatctgc agcgccagtg cgccattatc tgcgacgcgt tgcaagagcg     2220

cagcgatgtg cccctcgcca tagcggatgt cagccttgcc tacgaacgcc acctattctc     2280

accgcgcgta ccccccaaac gccaagaaaa cggcacatgc gagcccaacc cgcgcctcaa     2340

cttctacccc gtatttgccg tgccagaggt gcttgccacc tatcacatct ttttccaaaa     2400

ctgcaagata cccctatcct gccgtgccaa ccgcagccga gcggacaagc agctggcctt     2460

gcggcagggc gctgtcatac ctgatatcgc ctcgctcaac gaagtgccaa aaatctttga     2520

gggtcttgga cgcgacgaga agcgcgcggc aaacgctctg caacaggaaa acagcgaaaa     2580

tgaaagtcac tctggagtgt tggtggaact cgagggtgac aacgcgcgcc tagccgtact     2640

aaaacgcagc atcgaggtca cccactttgc ctacccggca cttaacctac cccccaaggt     2700

catgagcaca gtcatgagtg agctgatcgt gcgccgtgcg cagcccctgg agagggatgc     2760

aaatttgcaa gaacaaacag aggagggcct acccgcagtt ggcgacgagc agctagcgcg     2820

ctggcttcaa acgcgcgagc ctgccgactt ggaggagcga cgcaaactaa tgatggccgc     2880

agtgctcgtt accgtggagc ttgagtgcat gcagcggttc tttgctgacc cggagatgca     2940

gcgcaagcta gaggaaacat tgcactacac ctttcgacag ggctacgtac gccaggcctg     3000

caagatctcc aacgtggagc tctgcaacct ggtctcctac cttggaattt tgcacgaaaa     3060

ccgccttggg caaaacgtgc ttcattccac gctcaagggc gaggcgcgcc gcgactacgt     3120

ccgcgactgc gtttacttat ttctatgcta cacctggcag acggccatgg gcgtttggca     3180

gcagtgcttg gaggagtgca acctcaagga gctgcagaaa ctgctaaagc aaaacttgaa     3240

ggacctatgg acggccttca acgagcgctc cgtggccgcg cacctggcgg acatcatttt     3300

ccccgaacgc ctgcttaaaa ccctgcaaca gggtctgcca gacttcacca gtcaaagcat     3360

gttgcagaac tttaggaact ttatcctaga gcgctcagga atcttgcccg ccacctgctg     3420

tgcacttcct agcgactttg tgcccattaa gtaccgcgaa tgccctccgc cgctttgggg     3480

ccactgctac cttctgcagc tagccaacta ccttgcctac cactctgaca taatggaaga     3540

cgtgagcggt gacggtctac tggagtgtca ctgtcgctgc aacctatgca ccccgcaccg     3600

ctccctggtt tgcaattcgc agctgcttaa cgaaagtcaa attatcggta cctttgagct     3660

gcagggtccc tcgcctgacg aaaagtccgc ggctccgggg ttgaaactca ctccggggct     3720

gtggacgtcg gcttaccttc gcaaatttgt acctgaggac taccacgccc acgagattag     3780

gttctacgaa gaccaatccc gcccgcctaa tgcggagctt accgcctgcg tcattaccca     3840

gggccacatt cttggccaat tgcaagccat caacaaagcc cgccaagagt ttctgctacg     3900

aaagggacgg ggggtttact tggaccccca gtccggcgag gagctcaacc caatcccccc     3960

gccgccgcag ccctatcagc agcagccgcg ggcccttgct tcccaggatg gcacccaaaa     4020

agaagctgca gctgccgccg ccacccacgg acgaggagga atactgggac agtcaggcag     4080

aggaggtttt ggacgaggag gaggaggaca tgatggaaga ctgggagagc ctagacgagg     4140

aagcttccga ggtcgaagag gtgtcagacg aaacaccgtc accctcggtc gcattcccct     4200

cgccggcgcc ccagaaatcg gcaaccggtt ccagcatggc tacaacctcc gctcctcagg     4260

cgccgccggc actgcccgtt cgccgaccca accgtagatg ggacaccact ggaaccaggg     4320

ccggtaagtc caagcagccg ccgccgttag cccaagagca acaacagcgc caaggctacc     4380

gctcatggcg cgggcacaag aacgccatag ttgcttgctt gcaagactgt gggggcaaca     4440

tctccttcgc ccgccgcttt cttctctacc atcacggcgt ggccttcccc cgtaacatcc     4500

tgcattacta ccgtcatctc tacagcccat actgcaccgg cggcagcggc agcaacagca     4560

gcggccacac agaagcaaag gcgaccggat agcaagactc tgacaaagcc caagaaatcc     4620

acagcggcgg cagcagcagg aggaggagcg ctgcgtctgg cgcccaacga acccgtatcg     4680

acccgcgagc ttagaaacag gatttttccc actctgtatg ctatatttca acagagcagg     4740

ggccaagaac aagagctgaa aataaaaaac aggtctctgc gatccctcac ccgcagctgc     4800

ctgtatcaca aaagcgaaga tcagcttcgg cgcacgctgg aagacgcgga ggctctcttc     4860

agtaaatact gcgcgctgac tcttaaggac tagtttcgcg ccctttctca aatttaagcg     4920

cgaaaactac gtcatctcca gcggccacac ccggcgccag cacctgttgt cagcgccatt     4980

atgagcaagg aaattcccac gccctacatg tggagttacc agccacaaat gggacttgcg     5040

gctggagctg cccaagacta ctcaacccga ataaactaca tgagcgcggg accccacatg     5100

atatcccggg tcaacggaat acgcgcccac cgaaaccgaa ttcccttgga acaggcggct     5160

attaccacca cacctcgtaa taaccttaat ccccgtagtt ggcccgctgc cctggtgtac     5220

caggaaagtc ccgctcccac cactgtggta cttcccagag acgcccaggc cgaagttcag     5280

atgactaact caggggcgca gcttgcgggc ggctttcgtc acagggtgcg gtcgcccggg     5340

c                                                                     5341


<210>  18
<211>  573
<212>  DNA
<213>  Cytomegalovirus genus

<400>  18
agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac       60

ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa      120

tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt      180

atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc      240

ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat      300

gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atgctgatgc      360

ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc      420

tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa      480

aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg      540

tctatataag cagagctggt ttagtgaacc gtc                                   573


<210>  19
<211>  637
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV promoter inducible (p565-2xTetO)

<400>  19
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcactagt cgccgtgaac gtcaatggaa agtccctatt ggcgttacta tgggaacata      240

cgtcattatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac      300

cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatgct      360

gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac ggggatttcc      420

aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt      480

tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg      540

ggaggtctat ataagcagag ctgtccctat cagtgataga gatgtcccta tcagtgatag      600

agatcgtcga gcagctcgtt tagtgaaccg tcagatc                               637


<210>  20
<211>  2559
<212>  DNA
<213>  adeno-associated virus 2

<400>  20
cagttgcgca gccatcgacg tcagacgcgg aagcttcgat caactacgca gacaggtacc       60

aaaacaaatg ttctcgtcac gtgggcatga atctgatgct gtttccctgc agacaatgcg      120

agagaatgaa tcagaattca aatatctgct tcactcacgg acagaaagac tgtttagagt      180

gctttcccgt gtcagaatct caacccgttt ctgtcgtcaa aaaggcgtat cagaaactgt      240

gctacattca tcatatcatg ggaaaggtgc cagacgcttg cactgcctgc gatctggtca      300

atgtggattt ggatgactgc atctttgaac aataaatgat ttaaatcagg tatggctgcc      360

gatggttatc ttccagattg gctcgaggac actctctctg aaggaataag acagtggtgg      420

aagctcaaac ctggcccacc accaccaaag cccgcagagc ggcataagga cgacagcagg      480

ggtcttgtgc ttcctgggta caagtacctc ggacccttca acggactcga caagggagag      540

ccggtcaacg aggcagacgc cgcggccctc gagcacgaca aagcctacga ccggcagctc      600

gacagcggag acaacccgta cctcaagtac aaccacgccg acgcggagtt tcaggagcgc      660

cttaaagaag atacgtcttt tgggggcaac ctcggacgag cagtcttcca ggcgaaaaag      720

agggttcttg aacctctggg cctggttgag gaacctgtta agacggctcc gggaaaaaag      780

aggccggtag agcactctcc tgtggagcca gactcctcct cgggaaccgg aaaggcgggc      840

cagcagcctg caagaaaaag attgaatttt ggtcagactg gagacgcaga ctcagtacct      900

gacccccagc ctctcggaca gccaccagca gccccctctg gtctgggaac taatacgatg      960

gctacaggca gtggcgcacc aatggcagac aataacgagg gcgccgacgg agtgggtaat     1020

tcctcgggaa attggcattg cgattccaca tggatgggcg acagagtcat caccaccagc     1080

acccgaacct gggccctgcc cacctacaac aaccacctct acaaacaaat ttccagccaa     1140

tcaggagcct cgaacgacaa tcactacttt ggctacagca ccccttgggg gtattttgac     1200

ttcaacagat tccactgcca cttttcacca cgtgactggc aaagactcat caacaacaac     1260

tggggattcc gacccaagag actcaacttc aagctcttta acattcaagt caaagaggtc     1320

acgcagaatg acggtacgac gacgattgcc aataacctta ccagcacggt tcaggtgttt     1380

actgactcgg agtaccagct cccgtacgtc ctcggctcgg cgcatcaagg atgcctcccg     1440

ccgttcccag cagacgtctt catggtgcca cagtatggat acctcaccct gaacaacggg     1500

agtcaggcag taggacgctc ttcattttac tgcctggagt actttccttc tcagatgctg     1560

cgtaccggaa acaactttac cttcagctac acttttgagg acgttccttt ccacagcagc     1620

tacgctcaca gccagagtct ggaccgtctc atgaatcctc tcatcgacca gtacctgtat     1680

tacttgagca gaacaaacac tccaagtgga accaccacgc agtcaaggct tcagttttct     1740

caggccggag cgagtgacat tcgggaccag tctaggaact ggcttcctgg accctgttac     1800

cgccagcagc gagtatcaaa gacatctgcg gataacaaca acagtgaata ctcgtggact     1860

ggagctacca agtaccacct caatggcaga gactctctgg tgaatccggg cccggccatg     1920

gcaagccaca aggacgatga agaaaagttt tttcctcaga gcggggttct catctttggg     1980

aagcaaggct cagagaaaac aaatgtggac attgaaaagg tcatgattac agacgaagag     2040

gaaatcagga caaccaatcc cgtggctacg gagcagtatg gttctgtatc taccaacctc     2100

cagagaggca acagacaagc agctaccgca gatgtcaaca cacaaggcgt tcttccaggc     2160

atggtctggc aggacagaga tgtgtacctt caggggccca tctgggcaaa gattccacac     2220

acggacggac attttcaccc ctctcccctc atgggtggat tcggacttaa acaccctcct     2280

ccacagattc tcatcaagaa caccccggta cctgcgaatc cttcgaccac cttcagtgcg     2340

gcaaagtttg cttccttcat cacacagtac tccacgggac aggtcagcgt ggagatcgag     2400

tgggagctgc agaaggaaaa cagcaaacgc tggaatcccg aaattcagta cacttccaac     2460

tacaacaagt ctgttaatgt ggactttact gtggacacta atggcgtgta ttcagagcct     2520

cgccccattg gcaccagata cctgactcgt aatctgtaa                            2559


<210>  21
<211>  192
<212>  DNA
<213>  Simian virus 40

<400>  21
cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa       60

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca      120

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt      180

gggaggtttt tt                                                          192


