                               SEQUENCE LISTING

<110> BIO-RAD LABORATORIES, INC.
 
<120> MUTANT DNA POLYMERASES

<130> 094260-1116788 (115810PC)

<140>
<141>

<150> 62/619,394
<151> 2018-01-19

<160> 18    

<170> PatentIn version 3.5

<210> 1
<211> 830
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu Val Asp Gly 
1               5                   10                  15      


His His Leu Ala Tyr Arg Asn Phe Phe Thr Leu Lys Gly Pro Thr Thr 
            20                  25                  30          


Ser Arg Gly Glu Pro Val Gln Gly Val Tyr Gly Phe Ala Lys Ser Leu 
        35                  40                  45              


Ala Lys Ala Leu Lys Glu Asp Gly Asp Val Val Ile Val Val Phe Asp 
    50                  55                  60                  


Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Ala Tyr Lys Ala 
65                  70                  75                  80  


Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu Ala Leu Met 
                85                  90                  95      


Lys Glu Leu Val Asp Leu Leu Gly Leu Glu Arg Leu Glu Val Pro Gly 
            100                 105                 110         


Phe Glu Ala Asp Asp Val Leu Ala Ala Leu Ala Lys Ile Ala Glu Arg 
        115                 120                 125             


Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Arg Asp Leu Phe Gln 
    130                 135                 140                 


Leu Leu Ser Asp Arg Ile Ala Leu Leu His Pro Glu Gly His Leu Ile 
145                 150                 155                 160 


Thr Pro Gly Trp Leu Trp Glu Arg Tyr Gly Leu Arg Pro Glu Gln Trp 
                165                 170                 175     


Val Asp Phe Arg Ala Leu Ala Gly Asp Pro Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Lys Gly Ile Ser Glu Lys Thr Ala Leu Lys Leu Leu Lys Glu Trp 
        195                 200                 205             


Gly Ser Leu Glu Asn Ile Gln Lys Asn Leu Ala Gln Val Lys Pro Glu 
    210                 215                 220                 


Arg Val Arg Glu Ala Ile Arg Asn Asn Leu Asp Lys Leu Gln Met Ser 
225                 230                 235                 240 


Leu Glu Leu Ser Arg Leu Arg Thr Asp Leu Pro Leu Glu Val Asp Phe 
                245                 250                 255     


Arg Arg Arg Arg Glu Pro Asp Arg Glu Gly Leu Arg Ala Phe Leu Glu 
            260                 265                 270         


Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu Glu Ser 
        275                 280                 285             


Pro Lys Ala Leu Glu Glu Ala Leu Trp Pro Pro Pro Glu Gly Ala Phe 
    290                 295                 300                 


Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp Leu Leu 
305                 310                 315                 320 


Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro Glu Pro 
                325                 330                 335     


Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro Pro Gly 
        355                 360                 365             


Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn Thr Thr 
    370                 375                 380                 


Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu Glu Ala 
385                 390                 395                 400 


Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asp Leu Trp Gly 
                405                 410                 415     


Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu Val Glu 
            420                 425                 430         


Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly Val Arg 
        435                 440                 445             


Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala Glu Glu 
    450                 455                 460                 


Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His Pro Phe 
465                 470                 475                 480 


Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp Glu Leu 
                485                 490                 495     


Gly Leu Pro Ala Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg Ser Thr 
            500                 505                 510         


Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile Val Glu 
        515                 520                 525             


Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr Tyr Ile 
    530                 535                 540                 


Asp Pro Leu Pro Arg Leu Val His Pro Lys Thr Gly Arg Leu His Thr 
545                 550                 555                 560 


Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser Ser Asp 
                565                 570                 575     


Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln Arg Ile 
            580                 585                 590         


Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala Leu Asp 
        595                 600                 605             


Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly Asp Glu 
    610                 615                 620                 


Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr Glu Thr 
625                 630                 635                 640 


Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro Leu Met 
                645                 650                 655     


Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly Met Ser 
            660                 665                 670         


Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu Ala Gln 
        675                 680                 685             


Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg Ala Trp 
    690                 695                 700                 


Ile Ala His Thr Leu Glu Glu Gly Arg Lys Lys Gly Tyr Val Glu Thr 
705                 710                 715                 720 


Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Asn Ala Arg Val Lys 
                725                 730                 735     


Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Ala Val Gln 
            740                 745                 750         


Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu Phe Pro 
        755                 760                 765             


Arg Leu Pro Glu Val Gly Ala Arg Met Leu Leu Gln Val His Asp Glu 
    770                 775                 780                 


Leu Leu Leu Glu Ala Pro Lys Glu Arg Ala Glu Glu Ala Ala Ala Leu 
785                 790                 795                 800 


Ala Lys Glu Val Met Glu Gly Val Trp Pro Leu Ala Val Pro Leu Glu 
                805                 810                 815     


Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Gly 
            820                 825                 830 


<210> 2
<211> 830
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu Val Asp Gly 
1               5                   10                  15      


His His Leu Ala Tyr Arg Asn Phe Phe Thr Leu Lys Gly Leu Thr Thr 
            20                  25                  30          


Ser Arg Gly Glu Pro Val Gln Gly Val Tyr Gly Phe Ala Lys Ser Leu 
        35                  40                  45              


Ala Lys Ala Leu Lys Glu Asp Gly Asp Val Val Ile Val Val Phe Asp 
    50                  55                  60                  


Ala Glu Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Ala Tyr Lys Ala 
65                  70                  75                  80  


Gly Arg Ala Pro Thr Arg Glu Asp Phe Pro Arg Gln Leu Ala Leu Met 
                85                  90                  95      


Lys Glu Leu Val Asp Leu Leu Gly Leu Glu Arg Leu Glu Val Pro Gly 
            100                 105                 110         


Phe Glu Ala Asp Asp Val Leu Ala Ala Leu Ala Lys Ile Ala Glu Arg 
        115                 120                 125             


Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Arg Asp Leu Phe Gln 
    130                 135                 140                 


Leu Leu Ser Asp Arg Ile Ala Val Leu His Pro Glu Gly His Leu Ile 
145                 150                 155                 160 


Thr Pro Gly Trp Leu Trp Glu Arg Tyr Gly Leu Arg Pro Glu Gln Trp 
                165                 170                 175     


Val Asp Phe Arg Ala Leu Ala Gly Asp Pro Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Lys Gly Ile Ser Glu Lys Thr Ala Leu Lys Leu Leu Lys Glu Trp 
        195                 200                 205             


Gly Ser Leu Glu Asn Ile Gln Lys Asn Leu Ala Gln Val Lys Pro Glu 
    210                 215                 220                 


Arg Val Arg Glu Ala Ile Arg Asn Asn Leu Asp Lys Leu Gln Met Ser 
225                 230                 235                 240 


Leu Glu Leu Ser Arg Leu Arg Thr Asp Leu Pro Leu Glu Val Asp Phe 
                245                 250                 255     


Arg Arg Arg Arg Lys Pro Asp Arg Glu Gly Leu Arg Ala Phe Met Glu 
            260                 265                 270         


Arg Leu Glu Phe Asp Ser Leu Leu His Glu Phe Gly Leu Leu Glu Ser 
        275                 280                 285             


Pro Lys Ala Leu Glu Glu Ala Leu Trp Pro Pro Pro Glu Gly Ala Phe 
    290                 295                 300                 


Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp Leu Leu 
305                 310                 315                 320 


Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro Glu Pro 
                325                 330                 335     


Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro Pro Gly 
        355                 360                 365             


Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn Thr Thr 
    370                 375                 380                 


Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu Glu Ala 
385                 390                 395                 400 


Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asp Leu Trp Gly 
                405                 410                 415     


Arg Leu Glu Glu Glu Glu Arg Leu Leu Trp Leu Tyr His Glu Val Glu 
            420                 425                 430         


Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly Val Arg 
        435                 440                 445             


Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala Glu Glu 
    450                 455                 460                 


Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His Pro Phe 
465                 470                 475                 480 


Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp Glu Leu 
                485                 490                 495     


Gly Leu Pro Pro Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg Ser Thr 
            500                 505                 510         


Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile Val Glu 
        515                 520                 525             


Lys Ile Leu Gln Tyr Arg Glu Leu Ala Lys Leu Lys Ser Thr Tyr Ile 
    530                 535                 540                 


Asp Pro Leu Pro Arg Leu Val His Pro Lys Thr Gly Arg Leu His Thr 
545                 550                 555                 560 


Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser Ser Asp 
                565                 570                 575     


Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln Arg Ile 
            580                 585                 590         


Arg Lys Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala Leu Asp 
        595                 600                 605             


Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly Asp Glu 
    610                 615                 620                 


Asn Leu Ile Arg Val Phe Arg Glu Gly Lys Asp Ile His Thr Glu Thr 
625                 630                 635                 640 


Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro Leu Met 
                645                 650                 655     


Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly Met Ser 
            660                 665                 670         


Ala His Arg Leu Ser Gln Glu Leu Ser Ile Pro Tyr Glu Glu Ala Ala 
        675                 680                 685             


Ala Phe Ile Glu Arg Tyr Phe Gln Arg Phe Pro Gln Val Arg Ala Trp 
    690                 695                 700                 


Ile Ala His Thr Leu Glu Glu Gly Arg Lys Lys Gly Tyr Val Glu Thr 
705                 710                 715                 720 


Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Asn Ala Arg Val Lys 
                725                 730                 735     


Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Ala Val Gln 
            740                 745                 750         


Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu Phe Pro 
        755                 760                 765             


Arg Leu Arg Pro Leu Gly Val Arg Met Leu Leu Gln Val His Asp Glu 
    770                 775                 780                 


Leu Leu Leu Glu Ala Pro Lys Glu Arg Ala Glu Glu Ala Ala Ala Leu 
785                 790                 795                 800 


Ala Lys Glu Val Met Glu Gly Val Trp Pro Leu Ala Val Pro Leu Glu 
                805                 810                 815     


Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Gly 
            820                 825                 830 


<210> 3
<211> 830
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu Val Asp Gly 
1               5                   10                  15      


His His Leu Ala Tyr Arg Asn Phe Phe Thr Leu Arg Gly Leu Thr Thr 
            20                  25                  30          


Ser Arg Gly Glu Pro Val Gln Gly Val Tyr Gly Phe Ala Lys Ser Leu 
        35                  40                  45              


Ala Lys Ala Leu Lys Glu Asp Gly Asp Val Val Ile Val Val Phe Asp 
    50                  55                  60                  


Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Ala Tyr Lys Ala 
65                  70                  75                  80  


Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu Ala Leu Met 
                85                  90                  95      


Lys Glu Leu Val Asp Leu Leu Gly Leu Glu Arg Leu Glu Val Pro Gly 
            100                 105                 110         


Phe Glu Ala Asp Asp Val Leu Ala Ala Leu Ala Lys Ile Ala Glu Arg 
        115                 120                 125             


Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Arg Asp Leu Phe Gln 
    130                 135                 140                 


Leu Leu Ser Asp Arg Ile Ala Val Leu His Pro Glu Gly His Leu Ile 
145                 150                 155                 160 


Thr Pro Gly Trp Leu Trp Glu Arg Tyr Gly Leu Arg Pro Glu Gln Trp 
                165                 170                 175     


Val Asp Phe Arg Ala Leu Thr Gly Asp Pro Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Lys Gly Ile Gly Glu Lys Thr Ala Leu Lys Leu Leu Lys Glu Trp 
        195                 200                 205             


Gly Ser Leu Glu Asn Ile Gln Lys Asn Leu Asp Gln Val Lys Pro Glu 
    210                 215                 220                 


Arg Val Arg Glu Ala Ile Arg Asn Asn Leu Asp Lys Leu Gln Met Ser 
225                 230                 235                 240 


Leu Glu Leu Ser Arg Leu Arg Thr Asp Leu Pro Leu Glu Val Asp Phe 
                245                 250                 255     


Arg Arg Arg Arg Glu Pro Asp Arg Glu Gly Leu Arg Ala Phe Leu Glu 
            260                 265                 270         


Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu Glu Ser 
        275                 280                 285             


Pro Lys Ala Leu Glu Glu Ala Leu Trp Pro Pro Pro Glu Gly Ala Phe 
    290                 295                 300                 


Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp Leu Leu 
305                 310                 315                 320 


Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro Glu Pro 
                325                 330                 335     


Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro Pro Gly 
        355                 360                 365             


Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn Thr Thr 
    370                 375                 380                 


Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu Glu Ala 
385                 390                 395                 400 


Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu Trp Ser 
                405                 410                 415     


Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu Val Glu 
            420                 425                 430         


Arg Pro Leu Ser Val Val Leu Ala His Met Glu Ala Thr Gly Val Arg 
        435                 440                 445             


Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala Glu Glu 
    450                 455                 460                 


Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His Pro Phe 
465                 470                 475                 480 


Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp Glu Leu 
                485                 490                 495     


Gly Leu Pro Pro Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg Ser Thr 
            500                 505                 510         


Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile Val Glu 
        515                 520                 525             


Lys Ile Leu Gln Tyr Arg Glu Leu Ala Lys Leu Lys Ser Thr Tyr Ile 
    530                 535                 540                 


Asp Pro Leu Pro Arg Leu Val His Pro Lys Thr Gly Arg Leu His Thr 
545                 550                 555                 560 


Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser Ser Asp 
                565                 570                 575     


Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln Arg Ile 
            580                 585                 590         


Arg Lys Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala Leu Asp 
        595                 600                 605             


Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly Asp Glu 
    610                 615                 620                 


Asn Leu Ile Arg Val Phe Arg Glu Gly Lys Asp Ile His Thr Glu Thr 
625                 630                 635                 640 


Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro Leu Met 
                645                 650                 655     


Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly Met Ser 
            660                 665                 670         


Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu Ala Gln 
        675                 680                 685             


Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg Ala Trp 
    690                 695                 700                 


Ile Glu Lys Thr Leu Glu Glu Gly Arg Gln Arg Gly Tyr Val Glu Thr 
705                 710                 715                 720 


Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Asn Ala Arg Val Lys 
                725                 730                 735     


Arg Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Pro Val Gln 
            740                 745                 750         


Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Arg Leu Phe Pro 
        755                 760                 765             


Arg Leu Pro Glu Val Gly Ala Arg Met Leu Leu Gln Val His Asp Glu 
    770                 775                 780                 


Leu Leu Leu Glu Ala Pro Lys Glu Arg Ala Glu Glu Ala Ala Ala Leu 
785                 790                 795                 800 


Ala Arg Glu Val Met Glu Gly Val Trp Pro Leu Ala Val Pro Leu Glu 
                805                 810                 815     


Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Gly 
            820                 825                 830 


<210> 4
<211> 830
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu Val Asp Gly 
1               5                   10                  15      


His His Leu Ala Tyr Arg Asn Phe Phe Thr Leu Lys Gly Pro Thr Thr 
            20                  25                  30          


Ser Arg Gly Glu Pro Val Gln Gly Val Tyr Gly Phe Ala Lys Ser Leu 
        35                  40                  45              


Ala Lys Ala Leu Lys Glu Asp Gly Asp Val Val Ile Val Val Phe Asp 
    50                  55                  60                  


Ala Lys Ala Pro Ser Phe Arg His Glu Thr Tyr Gly Ala Tyr Lys Ala 
65                  70                  75                  80  


Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu Ala Leu Met 
                85                  90                  95      


Lys Glu Leu Val Asp Leu Leu Gly Leu Glu Arg Leu Glu Val Pro Gly 
            100                 105                 110         


Phe Glu Ala Asp Asp Val Leu Ala Ala Leu Ala Lys Ile Ala Glu Arg 
        115                 120                 125             


Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Arg Asp Leu Phe Gln 
    130                 135                 140                 


Leu Leu Ser Asp Arg Ile Ala Val Leu His Pro Glu Gly His Leu Ile 
145                 150                 155                 160 


Thr Pro Gly Trp Leu Trp Glu Arg Tyr Gly Leu Arg Pro Glu Gln Trp 
                165                 170                 175     


Val Asp Phe Arg Ala Leu Ala Gly Asp Pro Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Lys Gly Ile Gly Glu Lys Thr Ala Leu Lys Leu Leu Lys Glu Trp 
        195                 200                 205             


Gly Ser Leu Glu Asn Ile Gln Lys Asn Leu Asp Gln Val Lys Pro Glu 
    210                 215                 220                 


Arg Val Arg Glu Ala Ile Arg Asn Asn Leu Asp Lys Leu Gln Met Ser 
225                 230                 235                 240 


Leu Glu Leu Ser Arg Leu Arg Thr Asp Leu Pro Leu Glu Val Asp Phe 
                245                 250                 255     


Arg Arg Arg Arg Glu Pro Asp Arg Glu Gly Leu Arg Ala Phe Leu Glu 
            260                 265                 270         


Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu Glu Ser 
        275                 280                 285             


Pro Lys Ala Leu Glu Glu Ala Leu Trp Pro Pro Pro Glu Gly Ala Phe 
    290                 295                 300                 


Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp Leu Leu 
305                 310                 315                 320 


Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro Glu Pro 
                325                 330                 335     


Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro Pro Gly 
        355                 360                 365             


Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn Thr Thr 
    370                 375                 380                 


Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu Glu Ala 
385                 390                 395                 400 


Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu Trp Gly 
                405                 410                 415     


Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu Val Glu 
            420                 425                 430         


Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly Val Arg 
        435                 440                 445             


Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala Glu Glu 
    450                 455                 460                 


Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His Pro Phe 
465                 470                 475                 480 


Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp Glu Leu 
                485                 490                 495     


Gly Leu Pro Pro Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg Ser Thr 
            500                 505                 510         


Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile Val Glu 
        515                 520                 525             


Lys Ile Leu Gln Tyr Arg Glu Leu Ala Lys Leu Lys Ser Thr Tyr Ile 
    530                 535                 540                 


Asp Pro Leu Pro Arg Leu Val His Pro Lys Thr Gly Arg Leu His Thr 
545                 550                 555                 560 


Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser Ser Asp 
                565                 570                 575     


Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln Arg Ile 
            580                 585                 590         


Arg Lys Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala Leu Asp 
        595                 600                 605             


Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly Asp Glu 
    610                 615                 620                 


Asn Leu Ile Arg Val Phe Arg Glu Gly Lys Asp Ile His Thr Glu Thr 
625                 630                 635                 640 


Ala Ala Trp Met Phe Gly Val Pro Pro Glu Gly Val Asp Gly Ala Met 
                645                 650                 655     


Arg Arg Ala Ala Lys Thr Val Asn Phe Gly Val Leu Tyr Gly Met Ser 
            660                 665                 670         


Ala His Arg Leu Ser Gln Glu Leu Ser Ile Pro Tyr Glu Glu Ala Ala 
        675                 680                 685             


Ala Phe Ile Glu Arg Tyr Phe Gln Arg Phe Pro Gln Val Arg Ala Trp 
    690                 695                 700                 


Ile Ala His Thr Leu Glu Glu Gly Arg Lys Lys Gly Tyr Val Glu Thr 
705                 710                 715                 720 


Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Asn Ala Arg Val Lys 
                725                 730                 735     


Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Ala Val Gln 
            740                 745                 750         


Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu Phe Pro 
        755                 760                 765             


Arg Leu Pro Glu Val Gly Ala Arg Met Leu Leu Gln Val His Asp Glu 
    770                 775                 780                 


Leu Leu Leu Glu Ala Pro Lys Glu Arg Ala Glu Glu Ala Ala Ala Leu 
785                 790                 795                 800 


Ala Lys Glu Val Met Glu Gly Val Trp Pro Leu Ala Val Pro Leu Glu 
                805                 810                 815     


Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Gly 
            820                 825                 830 


<210> 5
<211> 830
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu Val Asp Gly 
1               5                   10                  15      


His His Leu Ala Tyr Arg Asn Phe Phe Thr Leu Lys Gly Leu Thr Thr 
            20                  25                  30          


Ser Arg Gly Glu Pro Val Gln Gly Val Tyr Gly Phe Ala Lys Ser Leu 
        35                  40                  45              


Ala Lys Ala Leu Lys Glu Asp Gly Asp Val Val Ile Val Val Phe Asp 
    50                  55                  60                  


Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Ala Tyr Lys Ala 
65                  70                  75                  80  


Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu Ala Leu Met 
                85                  90                  95      


Lys Glu Leu Val Asp Leu Leu Gly Leu Glu Arg Leu Glu Val Pro Gly 
            100                 105                 110         


Phe Glu Ala Asp Asp Val Leu Ala Ala Leu Ala Lys Ile Ala Glu Arg 
        115                 120                 125             


Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Arg Asp Leu Phe Gln 
    130                 135                 140                 


Leu Leu Ser Asp Arg Ile Ala Val Leu His Pro Glu Gly His Leu Ile 
145                 150                 155                 160 


Thr Pro Gly Trp Leu Trp Glu Arg Tyr Gly Leu Arg Pro Glu Gln Trp 
                165                 170                 175     


Val Asn Phe Arg Ala Leu Ala Gly Asp Pro Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Lys Gly Ile Gly Glu Lys Thr Ala Leu Lys Leu Leu Lys Glu Trp 
        195                 200                 205             


Gly Ser Leu Glu Asn Ile Gln Lys Asn Leu Asp Gln Val Lys Pro Glu 
    210                 215                 220                 


Arg Val Arg Glu Ala Ile Arg Asn Asn Leu Asp Lys Leu Gln Met Ser 
225                 230                 235                 240 


Leu Glu Leu Ser Cys Leu Arg Thr Asp Leu Pro Leu Glu Val Asp Phe 
                245                 250                 255     


Arg Arg Arg Arg Glu Pro Asp Arg Glu Gly Leu Arg Ala Phe Leu Glu 
            260                 265                 270         


Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu Glu Ser 
        275                 280                 285             


Pro Lys Ala Leu Glu Glu Ala Leu Trp Pro Pro Pro Glu Gly Ala Phe 
    290                 295                 300                 


Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp Leu Leu 
305                 310                 315                 320 


Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro Glu Pro 
                325                 330                 335     


Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu Ala Lys 
            340                 345                 350         


Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro Pro Gly 
        355                 360                 365             


Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn Thr Thr 
    370                 375                 380                 


Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu Glu Ala 
385                 390                 395                 400 


Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu Trp Gly 
                405                 410                 415     


Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu Val Glu 
            420                 425                 430         


Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly Val Arg 
        435                 440                 445             


Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala Glu Glu 
    450                 455                 460                 


Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His Pro Phe 
465                 470                 475                 480 


Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp Glu Leu 
                485                 490                 495     


Gly Leu Pro Pro Ile Gly Arg Thr Glu Lys Thr Gly Lys Arg Ser Thr 
            500                 505                 510         


Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile Val Glu 
        515                 520                 525             


Lys Ile Leu Gln Tyr Arg Glu Leu Ala Lys Leu Lys Ser Thr Tyr Ile 
    530                 535                 540                 


Asp Pro Leu Pro Arg Leu Val His Pro Lys Thr Gly Arg Leu His Thr 
545                 550                 555                 560 


Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser Ser Asp 
                565                 570                 575     


Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln Arg Ile 
            580                 585                 590         


Arg Lys Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala Leu Asp 
        595                 600                 605             


Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly Asp Glu 
    610                 615                 620                 


Asn Leu Ile Arg Val Phe Arg Glu Gly Lys Asp Ile His Thr Glu Thr 
625                 630                 635                 640 


Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro Leu Met 
                645                 650                 655     


Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly Met Ser 
            660                 665                 670         


Ala His Arg Leu Ser Gln Glu Leu Ser Ile Pro Tyr Glu Glu Ala Val 
        675                 680                 685             


Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Gln Val Arg Ala Trp 
    690                 695                 700                 


Ile Ala His Thr Leu Glu Glu Gly Arg Lys Lys Gly Tyr Val Glu Thr 
705                 710                 715                 720 


Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Asn Ala Arg Val Lys 
                725                 730                 735     


Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Ala Val Gln 
            740                 745                 750         


Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu Phe Pro 
        755                 760                 765             


Arg Leu Pro Glu Val Gly Ala Arg Met Leu Leu Gln Val His Asp Glu 
    770                 775                 780                 


Leu Leu Leu Glu Ala Pro Lys Glu Arg Ala Glu Glu Ala Ala Ala Leu 
785                 790                 795                 800 


Ala Lys Glu Val Met Glu Gly Val Trp Pro Leu Ala Val Pro Leu Glu 
                805                 810                 815     


Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 
            820                 825                 830 


<210> 6
<211> 829
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu Val Asp Gly 
1               5                   10                  15      


His His Leu Ala His Arg Asn Phe Phe Ala Leu Lys Gly Leu Thr Thr 
            20                  25                  30          


Ser Arg Gly Glu Pro Val Gln Gly Val Tyr Gly Phe Ala Lys Ser Leu 
        35                  40                  45              


Leu Lys Ala Leu Lys Glu Asp Gly Asp Val Val Ile Val Val Phe Asp 
    50                  55                  60                  


Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Ala Tyr Lys Ala 
65                  70                  75                  80  


Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu Ala Leu Ile 
                85                  90                  95      


Lys Glu Leu Val Asp Leu Leu Gly Leu Val Arg Leu Glu Val Pro Gly 
            100                 105                 110         


Phe Glu Ala Asp Asp Val Leu Ala Thr Leu Ala Lys Lys Ala Glu Lys 
        115                 120                 125             


Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp Leu Tyr Gln 
    130                 135                 140                 


Ile Leu Ser Asp Arg Val His Val Leu His Pro Glu Gly Tyr Leu Ile 
145                 150                 155                 160 


Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro Asp Gln Trp 
                165                 170                 175     


Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn Leu Pro Gly 
            180                 185                 190         


Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu Glu Glu Trp 
        195                 200                 205             


Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu Lys Pro Ala 
    210                 215                 220                 


Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys Leu Ser Trp 
225                 230                 235                 240 


Asp Pro Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val Asp Phe Ala 
                245                 250                 255     


Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe Leu Glu Arg 
            260                 265                 270         


Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu Glu Ser Pro 
        275                 280                 285             


Lys Ala Leu Glu Glu Ala Leu Trp Pro Pro Pro Glu Gly Ala Phe Val 
    290                 295                 300                 


Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp Leu Leu Ala 
305                 310                 315                 320 


Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro Glu Pro Tyr 
                325                 330                 335     


Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu Ala Lys Asp 
            340                 345                 350         


Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro Pro Gly Asp 
        355                 360                 365             


Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn Thr Thr Pro 
    370                 375                 380                 


Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu Glu Ala Gly 
385                 390                 395                 400 


Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asp Leu Trp Gly Arg 
                405                 410                 415     


Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu Val Glu Arg 
            420                 425                 430         


Pro Leu Ser Ala Val Leu Ala Arg Met Glu Ala Thr Gly Val Arg Leu 
        435                 440                 445             


Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala Glu Glu Ile 
    450                 455                 460                 


Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His Pro Phe Asn 
465                 470                 475                 480 


Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp Glu Leu Gly 
                485                 490                 495     


Leu Pro Ala Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg Ser Thr Ser 
            500                 505                 510         


Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile Val Glu Lys 
        515                 520                 525             


Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr Tyr Ile Asp 
    530                 535                 540                 


Pro Leu Pro Arg Leu Val His Pro Lys Thr Gly Arg Leu His Thr Arg 
545                 550                 555                 560 


Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser Ser Asp Pro 
                565                 570                 575     


Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln Arg Ile Arg 
            580                 585                 590         


Lys Ala Phe Ile Ala Glu Glu Gly His Leu Leu Val Ala Leu Asp Tyr 
        595                 600                 605             


Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly Asp Glu Asn 
    610                 615                 620                 


Leu Ile Arg Val Phe Gln Glu Gly Lys Asp Ile His Thr Glu Thr Ala 
625                 630                 635                 640 


Ala Trp Met Phe Gly Val Pro Pro Glu Gly Val Asp Gly Ala Met Arg 
                645                 650                 655     


Arg Ala Ala Lys Thr Val Asn Phe Gly Val Leu Tyr Gly Met Ser Ala 
            660                 665                 670         


His Arg Leu Ser Gln Glu Leu Ser Ile Pro Tyr Glu Glu Ala Ala Ala 
        675                 680                 685             


Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Gln Val Arg Ala Trp Ile 
    690                 695                 700                 


Ala His Thr Leu Glu Glu Gly Arg Lys Lys Gly Tyr Val Glu Thr Leu 
705                 710                 715                 720 


Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Asn Ala Arg Val Lys Ser 
                725                 730                 735     


Val Arg Lys Ala Ala Glu Arg Met Ala Phe Asn Met Ala Val Gln Gly 
            740                 745                 750         


Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu Phe Pro Arg 
        755                 760                 765             


Leu Pro Glu Val Gly Ala Arg Met Leu Leu Gln Val His Asp Glu Leu 
    770                 775                 780                 


Leu Leu Glu Ala Pro Lys Glu Arg Ala Glu Glu Ala Ala Ala Leu Ala 
785                 790                 795                 800 


Lys Glu Val Met Glu Gly Val Trp Pro Leu Ala Val Pro Leu Glu Val 
                805                 810                 815     


Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Gly 
            820                 825                 


<210> 7
<211> 829
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu Val Asp Gly 
1               5                   10                  15      


His His Leu Ala Tyr Arg Thr Phe Phe Ala Leu Lys Gly Leu Thr Thr 
            20                  25                  30          


Ser Arg Gly Glu Pro Val Gln Gly Val Tyr Gly Phe Ala Lys Ser Leu 
        35                  40                  45              


Leu Lys Ala Leu Lys Glu Asp Gly Glu Val Ala Ile Val Val Phe Asp 
    50                  55                  60                  


Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Glu Ala Tyr Lys Ala 
65                  70                  75                  80  


Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu Ala Leu Ile 
                85                  90                  95      


Lys Glu Leu Val Asp Leu Leu Gly Leu Val Arg Leu Glu Val Pro Gly 
            100                 105                 110         


Phe Glu Ala Asp Asp Val Leu Ala Ala Leu Ala Lys Lys Ala Glu Arg 
        115                 120                 125             


Glu Gly Tyr Glu Val Arg Ile Leu Ser Ala Asp Arg Asp Leu Tyr Gln 
    130                 135                 140                 


Leu Leu Ser Asp Arg Ile His Leu Leu His Pro Glu Gly Tyr Leu Ile 
145                 150                 155                 160 


Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro Asp Gln Trp 
                165                 170                 175     


Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn Leu Pro Gly 
            180                 185                 190         


Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu Glu Glu Trp 
        195                 200                 205             


Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu Lys Pro Ala 
    210                 215                 220                 


Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys Leu Ser Trp 
225                 230                 235                 240 


Asp Pro Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val Asp Phe Ala 
                245                 250                 255     


Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe Leu Glu Arg 
            260                 265                 270         


Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu Glu Ser Pro 
        275                 280                 285             


Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro Pro Glu Gly Ala Phe Val 
    290                 295                 300                 


Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp Leu Leu Ala 
305                 310                 315                 320 


Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro Glu Pro Tyr 
                325                 330                 335     


Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu Ala Lys Asp 
            340                 345                 350         


Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro Pro Gly Asp 
        355                 360                 365             


Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn Thr Thr Pro 
    370                 375                 380                 


Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu Glu Ala Gly 
385                 390                 395                 400 


Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu Trp Gly Arg 
                405                 410                 415     


Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu Val Glu Arg 
            420                 425                 430         


Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly Val Arg Leu 
        435                 440                 445             


Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala Glu Glu Ile 
    450                 455                 460                 


Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His Pro Phe Asn 
465                 470                 475                 480 


Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp Glu Leu Gly 
                485                 490                 495     


Leu Pro Ala Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg Ser Thr Ser 
            500                 505                 510         


Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile Val Glu Lys 
        515                 520                 525             


Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr Tyr Ile Asp 
    530                 535                 540                 


Pro Leu Pro Arg Leu Val His Pro Lys Thr Gly Arg Leu His Thr Arg 
545                 550                 555                 560 


Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser Ser Asp Pro 
                565                 570                 575     


Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln Arg Ile Arg 
            580                 585                 590         


Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala Leu Asp Tyr 
        595                 600                 605             


Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly Asp Glu Asn 
    610                 615                 620                 


Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr Glu Thr Ala 
625                 630                 635                 640 


Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro Leu Met Arg 
                645                 650                 655     


Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly Met Ser Ala 
            660                 665                 670         


His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu Ala Gln Ala 
        675                 680                 685             


Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg Ala Trp Ile 
    690                 695                 700                 


Glu Arg Thr Leu Glu Glu Gly Arg Gln Arg Gly Tyr Val Glu Thr Leu 
705                 710                 715                 720 


Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Asn Ala Arg Val Lys Arg 
                725                 730                 735     


Val Arg Lys Ala Ala Glu Arg Met Ala Phe Asn Met Pro Val Gln Gly 
            740                 745                 750         


Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Arg Leu Phe Pro Arg 
        755                 760                 765             


Leu Pro Glu Val Gly Ala Arg Met Leu Leu Gln Val His Asp Glu Leu 
    770                 775                 780                 


Leu Leu Glu Ala Pro Lys Glu Arg Ala Glu Glu Ala Ala Gln Leu Ala 
785                 790                 795                 800 


Lys Glu Thr Met Glu Gly Val Trp Pro Leu Ala Val Pro Leu Glu Val 
                805                 810                 815     


Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 
            820                 825                 


<210> 8
<211> 832
<212> PRT
<213> Thermus aquaticus

<400> 8
Met Arg Gly Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe His Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Asp Ala Val Ile Val 
    50                  55                  60                  


Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Gly Gly 
65                  70                  75                  80  


Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln Leu 
                85                  90                  95      


Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Leu Ala Arg Leu Glu 
            100                 105                 110         


Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Ser Leu Ala Lys Lys 
        115                 120                 125             


Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Lys Asp 
    130                 135                 140                 


Leu Tyr Gln Leu Leu Ser Asp Arg Ile His Val Leu His Pro Glu Gly 
145                 150                 155                 160 


Tyr Leu Ile Thr Pro Ala Trp Leu Trp Glu Lys Tyr Gly Leu Arg Pro 
                165                 170                 175     


Asp Gln Trp Ala Asp Tyr Arg Ala Leu Thr Gly Asp Glu Ser Asp Asn 
            180                 185                 190         


Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Arg Lys Leu Leu 
        195                 200                 205             


Glu Glu Trp Gly Ser Leu Glu Ala Leu Leu Lys Asn Leu Asp Arg Leu 
    210                 215                 220                 


Lys Pro Ala Ile Arg Glu Lys Ile Leu Ala His Met Asp Asp Leu Lys 
225                 230                 235                 240 


Leu Ser Trp Asp Leu Ala Lys Val Arg Thr Asp Leu Pro Leu Glu Val 
                245                 250                 255     


Asp Phe Ala Lys Arg Arg Glu Pro Asp Arg Glu Arg Leu Arg Ala Phe 
            260                 265                 270         


Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly Leu Leu 
        275                 280                 285             


Glu Ser Pro Lys Ala Leu Glu Glu Ala Pro Trp Pro Pro Pro Glu Gly 
    290                 295                 300                 


Ala Phe Val Gly Phe Val Leu Ser Arg Lys Glu Pro Met Trp Ala Asp 
305                 310                 315                 320 


Leu Leu Ala Leu Ala Ala Ala Arg Gly Gly Arg Val His Arg Ala Pro 
                325                 330                 335     


Glu Pro Tyr Lys Ala Leu Arg Asp Leu Lys Glu Ala Arg Gly Leu Leu 
            340                 345                 350         


Ala Lys Asp Leu Ser Val Leu Ala Leu Arg Glu Gly Leu Gly Leu Pro 
        355                 360                 365             


Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro Ser Asn 
    370                 375                 380                 


Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp Thr Glu 
385                 390                 395                 400 


Glu Ala Gly Glu Arg Ala Ala Leu Ser Glu Arg Leu Phe Ala Asn Leu 
                405                 410                 415     


Trp Gly Arg Leu Glu Gly Glu Glu Arg Leu Leu Trp Leu Tyr Arg Glu 
            420                 425                 430         


Val Glu Arg Pro Leu Ser Ala Val Leu Ala His Met Glu Ala Thr Gly 
        435                 440                 445             


Val Arg Leu Asp Val Ala Tyr Leu Arg Ala Leu Ser Leu Glu Val Ala 
    450                 455                 460                 


Glu Glu Ile Ala Arg Leu Glu Ala Glu Val Phe Arg Leu Ala Gly His 
465                 470                 475                 480 


Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu Phe Asp 
                485                 490                 495     


Glu Leu Gly Leu Pro Ala Ile Gly Lys Thr Glu Lys Thr Gly Lys Arg 
            500                 505                 510         


Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His Pro Ile 
        515                 520                 525             


Val Glu Lys Ile Leu Gln Tyr Arg Glu Leu Thr Lys Leu Lys Ser Thr 
    530                 535                 540                 


Tyr Ile Asp Pro Leu Pro Asp Leu Ile His Pro Arg Thr Gly Arg Leu 
545                 550                 555                 560 


His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu Ser Ser 
                565                 570                 575     


Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu Gly Gln 
            580                 585                 590         


Arg Ile Arg Arg Ala Phe Ile Ala Glu Glu Gly Trp Leu Leu Val Ala 
        595                 600                 605             


Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu Ser Gly 
    610                 615                 620                 


Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Arg Asp Ile His Thr 
625                 630                 635                 640 


Glu Thr Ala Ser Trp Met Phe Gly Val Pro Arg Glu Ala Val Asp Pro 
                645                 650                 655     


Leu Met Arg Arg Ala Ala Lys Thr Ile Asn Phe Gly Val Leu Tyr Gly 
            660                 665                 670         


Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr Glu Glu 
        675                 680                 685             


Ala Gln Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys Val Arg 
    690                 695                 700                 


Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Arg Arg Gly Tyr Val 
705                 710                 715                 720 


Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Glu Ala Arg 
                725                 730                 735     


Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn Met Pro 
            740                 745                 750         


Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val Lys Leu 
        755                 760                 765             


Phe Pro Arg Leu Glu Glu Met Gly Ala Arg Met Leu Leu Gln Val His 
    770                 775                 780                 


Asp Glu Leu Val Leu Glu Ala Pro Lys Glu Arg Ala Glu Ala Val Ala 
785                 790                 795                 800 


Arg Leu Ala Lys Glu Val Met Glu Gly Val Tyr Pro Leu Ala Val Pro 
                805                 810                 815     


Leu Glu Val Glu Val Gly Ile Gly Glu Asp Trp Leu Ser Ala Lys Glu 
            820                 825                 830         


<210> 9
<211> 2493
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
atgctgccgc tgtttgagcc gaaaggtcgt gtgctgctgg ttgacggtca tcatctggcg       60

tatcgtaact tctttacgct gaaaggtccg accaccagcc gtggtgagcc ggtgcaaggt      120

gtttacggct tcgcgaaaag cctggcgaag gcgctgaaag aagacggcga tgtggttatc      180

gtggttttcg acgcgaaagc gccgagcttt cgtcacgagg cgtacggtgc gtataaagcg      240

ggtcgtgcgc cgaccccgga ggacttcccg cgtcagctgg cgctgatgaa ggaactggtg      300

gatctgctgg gtctggagcg tctggaagtt ccgggctttg aagcggatga tgttctggcg      360

gcgctggcga agatagcgga gcgtgagggt tacgaagtgc gtattctgac cgcggaccgt      420

gacctgttcc aactgctgag cgaccgtatc gcgcttctgc acccggaagg tcacctgatt      480

accccgggct ggctgtggga gcgttatggt ctgcgtccgg aacagtgggt ggattttcgt      540

gcgctggcgg gtgacccgag cgataacatc ccgggcgtta aaggtattag cgagaagatc      600

gcgctgaagc tgctgaaaga gtggggcagc ctggaaaaca tccagaaaaa cctggctcag      660

gtgaagccgg aacgtgttcg tgaggcgatt cgtaacaacc tggacaagct gcaaatgagc      720

ctggaactga gccgtctgcg taccgacctg ccgctggaag ttgatttccg tcgtcgtcgt      780

gaaccggatc gtgagggtct gggtgcgttc ctggaacgtc tggagtttgg tagcctgctg      840

cacgaatttg gcctcttaga atcacccaaa gccctggaag aagcactgtg gcctccacct      900

gaaggcgcct ttgttggttt tgttttgtct cgtaaagaac ctatgtgggc cgatttactg      960

gccttagccg ctgcacgtgg tggtcgtgtc catcgcgcac cagaacctta taaagcactg     1020

cgtgatctta aagaagctcg tggtctcctc gccaaagact tatccgtatt agcactccgc     1080

gagggtttag ggctgccacc tggtgatgat ccaatgttac ttgcatatct cctggatccc     1140

tctaatacaa ccccggaagg cgtggctcgt cgttatggtg atgaatggac tgaagaagct     1200

ggtgaacgtg cggctttgtc tgaacgctta ttcgctgacc tgtggggccg tctggaagga     1260

gaggaacgct tactctggtt atatcgtgaa gttgaacgcc cactgtcagc agtacttgcg     1320

cacatggaag ctaccggggt ccgcttagat gttgcctatc tccgtgctct gagtcttgaa     1380

gtagccgaag agattgcgcg cctagaagcc gaagtatttc gtctggccgg tcacccgttc     1440

aaccttaatt cccgtgatca actggaacgc gttttgtttg atgaacttgg cctgcccgca     1500

attggtaaaa ctgaaaaaac tggtaaacgt tcgacctccg ccgcagtcct tgaagccctg     1560

cgtgaagccc acccaattgt cgaaaaaatc ctgcagtacc gcgaactcac taaacttaaa     1620

tctacctata ttgacccgct gccgcgtctg gtgcacccga aaaccggacg tcttcacacc     1680

cgttttaatc aaactgctac cgcgactgga cgtttaagct catccgatcc caacttgcaa     1740

aatattcctg tccgtacccc actagggcaa cgtattcgcc gcgcatttat cgcagaggaa     1800

ggttggttgc tggtggcatt agattatagc caaattgaat tacgtgttct tgcgcattta     1860

tccggtgacg aaaatctcat tcgtgttttt caggagggac gtgatattca cacagaaacc     1920

gcttcatgga tgtttggtgt tccgcgtgaa gccgtcgacc cgttaatgcg tcgcgctgca     1980

aaaaccatta atttcggtgt tctgtatggt atgagtgcac atcggttatc acaagaactc     2040

gctatcccgt acgaagaagc tcaagcattt attgaacgtt attttcagag ttttcctaag     2100

gttcgtgcgt ggatcgcgca caccctggaa gagggtcgta agaaaggcta cgtggagacc     2160

ctgttcggtc gtcgtcgtta cgttccggac ctgaacgcgc gtgtgaaaag cgttcgtgaa     2220

gcggcggagc gtatggcgtt caacatggcg gtgcaaggta ccgcggcgga cctgatgaag     2280

ctggcgatgg tgaagctgtt tccgcgtctg ccggaagtgg gtgcgcgtat gctgctgcag     2340

gtgcacgatg aactgctgct ggaggcgccg aaagagcgtg cggaagaggc ggcggcgctg     2400

gcgaaggaag tgatggaggg tgtttggccg ctggcggtgc cgctggaagt ggaagttggt     2460

atcggtgaag actggctgag cgcgaagggc taa                                  2493


<210> 10
<211> 2545
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atgctgccgc tgtttgagcc gaaaggtcgt gtgctgctgg ttgacggtca tcatctggcg       60

tatcgtaact tctttacgct gaaaggtctg accaccagcc gtggtgagcc ggtgcaaggt      120

gtttacggct tcgcgaaaag cctggcgaag gcgctgaaag aagacggcga tgtggttatc      180

gtggttttcg acgcggaagc gccgagcttt cgtcacgagg cgtacggtgc gtataaagcg      240

ggtcgtgcgc cgacccggga ggacttcccg cgtcagctgg cgctgatgaa ggaactggtg      300

gatctgctgg gtctggaacg tctggaagtt ccgggctttg aagcggatga tgttctggcg      360

gcgctggcga agatagcgga acgtgagggt tacgaagtgc gtattctgac cgcggaccgt      420

gacctgttcc aactgctgag cgaccgtatc gcggttctgc acccggaagg tcacctgatt      480

accccgggct ggctgtggga gcgttatggt ctgcgtccgg aacagtgggt ggattttcgt      540

gcgctggcgg gtgaccctag cgataacatc ccgggcgtta aaggtattag cgagaagacc      600

gcgctgaagc tgctgaaaga gtggggcagc ctggaaaaca tccagaaaaa cctggctcag      660

gtgaagccgg aacgtgttcg tgaggcgatt cgtaacaacc tggacaagct gcaaatgagc      720

ctggaactga gccgtctgcg taccgacctg ccgctggaag ttgatttccg tcgtcgtcgt      780

aaaccggatc gtgagggtct gcgtgcattc atggaacgtc tggagtttga tagcctgctg      840

cacgaatttg gcctcttaga atcacccaag gccctggaag aagcactgtg gcccccacct      900

gaaggcgcct ttgttggttt tgttttgtct cgtaaagaac ctatgtgggc cgatttactg      960

gccttagccg ctgcacgtgg tggtcgtgtc catcgcgcac cagaacctta taaagcactg     1020

cgtgatctta aagaagctcg tggtctcctc gccaaagact tatccgtatt agcactccgc     1080

gagggtttag ggctgccacc tggtgatgat ccaatgttac ttgcatatct cctggatccc     1140

tctaatacaa ccccggaagg cgtggctcgt cgttatggtg gtgaatggac tgaagaagct     1200

ggtgaacgtg cggctttgtc cgaacgctta ttcgctgacc tgtggggccg tctggaagaa     1260

gaggaacgct tactctggtt atatcatgaa gttgaacgcc cactgtcagc agtacttgcg     1320

cacatggaag ctaccggggt ccgcttagat gttgcctatc tccgtgctct gagtcttgaa     1380

gtagccgaag aaattgcgcg cctggaagcc gaagtatttc gtctggcggg ccacccgttt     1440

aacctgaaca gccgtgacca gctggaacgt gttctgtttg atgaactggg tctgccgccg     1500

atcggcaaga ccgagaaaac cggtaaacgt agcaccagcg cggcggtgct ggaagcgctg     1560

cgtgaggcgc acccgatcgt tgagaagatt ctgcaatacc gtgaactggc gaagctgaaa     1620

agcacctata ttgacccgct gccgcgtctg gtgcacccga aaaccggtcg tctgcacacc     1680

cgtttcaacc aaaccgcgac cgcgaccggc cgtctgagca gcagcgatcc gaacctgcag     1740

aacatcccgg ttcgtacccc gctgggtcaa cgtatccgta aggcgtttat cgcagaagaa     1800

ggttggctgc tggtggcatt agattatagc caaattgaac tgcgtgttct ggcgcacctg     1860

agcggtgacg agaacctgat ccgtgtgttc cgtgaaggca aagatattca caccgagacc     1920

gcttcatgga tgtttggtgt tccgcgtgaa gccgtcgacc cgttaatgcg tcgcgctgca     1980

aaaaccatta attttggtgt tctgtatggt atgagcgcgc accgtctgag ccaggaactg     2040

agcatcccgt atgaagaggc ggcggcgttt attgagcgtt atttccagcg ctttccgcaa     2100

gtgcgtgcgt ggatcgcgca caccctggaa gagggtcgta agaaaggcta cgtggagacc     2160

ctgttcggtc gtcgtcgtta cgttccggac ctgaacgcgc gtgtgaaaag cgttcgtgaa     2220

gcagcggagc gtatggcgtt caacatggcg gtgcaaggta ccgcggcgga cctgatgaag     2280

ctggcgatgg tgaagctgtt tccgcgtctg cgtccgctgg gcgttcgtat gctgctgcag     2340

gttcacgatg aactgctgct ggaggcgccg aaagagcgtg cggaagaggc ggcggcgctg     2400

gcgaaggaag tgatggaggg tgtttggccg ctggcggtgc cgctggaagt ggaagttggt     2460

atcggtgaag actggctgag cgcgaagggc taatatctaa ctaagcttga cctgtgaagt     2520

gaaaaatggc gcacatggcg acatt                                           2545


<210> 11
<211> 2493
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
atgctgccgc tgtttgagcc gaaaggtcgt gtgctgctgg ttgacggtca tcatctggcg       60

tatcgtaact tctttacgct gagaggtctg accaccagcc gtggtgagcc tgtgcaaggt      120

gtttacggct tcgcgaaaag cctggcgaag gcgctgaaag aagacggcga tgtggttatc      180

gtggttttcg acgcgaaagc gccgagcttt cgtcacgagg cgtacggtgc gtataaagcg      240

ggtcgtgcgc cgaccccgga ggacttcccg cgtcagctgg cgctgatgaa ggaactggtg      300

gatctgctgg gtctggagcg tctggaagtt ccgggccttg aagcggatga tgttttggcg      360

gcgctggcga agatagcgga acgtgagggt tacgaagtgc gtattctgac cgcggaccgt      420

gacctgttcc aactgctgag cgaccgtatc gcggttctgc acccggaagg tcacctgatt      480

accccgggct ggctgtggga gcgttatggt ctgcgtccgg aacagtgggt ggattttcgt      540

gcgctgacgg gtgacccgag cgataacatc ccgggcgtta aaggtattgg cgagaagacc      600

gcgctgaagc tgctgaaaga gtggggcagc ctggaaaaca tccagaaaaa cctggatcag      660

gtgaagccgg aacgtgttcg tgaggcgatt cgtaacaacc tggacaagct gcaaatgagc      720

ctggaactga gccgtctgcg taccgacctg ccgctggaag ttgatttccg tcgtcgtcgt      780

gaaccggatc gtgagggtct gcgtgcgttc ctggaacgtc tggagtttgg tagcctgctg      840

cacgaatttg gcctcttaga atcacccaag gccctggaag aagcactgtg gcctccacct      900

gaaggcgcct ttgttggttt tgttttgtct cgtaaagaac ctatgtgggc cgatttactg      960

gccttagccg ctgcacgtgg tggtcgtgtc catcgcgcac cagaacctta taaagcactg     1020

cgtgacctta aagaagctcg tggtctcctc gccaaagact tatccgtatt agcactccgc     1080

gagggtttag ggctgccacc tggtgatgat ccaatgttac ttgcatatct cctggatccc     1140

tctaatacaa ccccggaagg cgtggctcgt cgttatggtg gtgaatggac tgaagaagct     1200

ggtgaacgtg cggctttgtc tgaacgctta ttcgctaacc tgtggagccg tctggaagga     1260

gaggaacgct tactctggtt atatcgtgaa gttgaacgcc cactgtcagt agtactagcg     1320

cacatggaag ctaccggggt ccgcttagat gttgcctatc tccgtgctct gagtcttgaa     1380

gtagccgaag aaattgcgcg cctggaagcc gaagtatttc gtctggcggg ccacccgttt     1440

aacctgaaca gccgtgacca gctggaacgt gttctgtttg atgaactggg tctgccgccg     1500

atcggcaaga ccgagaaaac cggtaaacgt agcaccagcg cggcggtgct ggaagcgctg     1560

cgtgaggcgc acccgatcgt tgagaagatt ctgcaatacc gtgaactggc gaagctgaaa     1620

agcacctata ttgacccgct gccgcgtctg gtgcacccga aaaccggtcg tctgcacacc     1680

cgtttcaacc aaaccgcgac cgcgaccggc cgtctgagca gcagcgatcc gaacctgcag     1740

aacatcccgg ttcgtacccc gctgggtcaa cgtatccgta aggcgtttat cgcagaagaa     1800

ggttggctgc tggtggcatt agattatagc caaattgaac tgcgtgttct ggcgcacctg     1860

agcggtgacg agaacctgat ccgtgtgttc cgtgaaggca aagatattca caccgagacc     1920

gcttcatgga tgtttggtgt tccgcgtgaa gccgtcgacc cgttaatgcg tcgcgctgca     1980

aaaaccatta attttggtgt tctgtatggt atgagtgcac atcggttatc acaagaactc     2040

gctatcccgt atgaagaagc tcaagcattt attgaacgtt attttcagag ttttcctaag     2100

gttcgtgctt ggattgaaaa aacattggaa gagggtcgtc agcgtggcta cgtggaaacc     2160

ctgtttggtc gtcgtcgtta cgttccggat ctgaacgcgc gtgtgaaaag ggttcgtgaa     2220

gcggcggagc gtatggcgtt caacatgccg gttcaaggta ccgcggcgga cctgatgaag     2280

ctggcgatgg ttcgtctgtt cccgcgtctg ccggaagtgg gtgcgcgtat gctgctgcag     2340

gttcacgatg aactgctgct ggaggcgccg aaagagcgtg cggaagaggc ggcggcgctg     2400

gcgagggaag tgatggaggg tgtttggccg ctggcggtgc cgctggaagt ggaagttggt     2460

attggtgaag actggctgag cgcgaagggc taa                                  2493


<210> 12
<211> 2493
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
atgctgccgc tgtttgagcc gaaaggtcgt gtgctgctgg ttgacggtca tcatctggcg       60

tatcgtaact tctttacgct gaaaggtccg accaccagcc gtggtgagcc ggtgcaaggt      120

gtttacggct tcgcgaaaag cctggcgaag gcgctgaaag aagacggcga tgtggttatc      180

gtggttttcg acgcgaaagc gccgagcttt cgtcacgaga cgtacggtgc gtataaagcg      240

ggtcgtgcgc cgaccccgga ggacttcccg cgtcagctgg cgctgatgaa ggaactggtg      300

gatctgctgg gtctggagcg tctggaagtt ccgggctttg aagcggatga tgttctggcg      360

gcgctggcga agatagcgga gcgtgagggt tacgaagtgc gtattctgac cgcggaccgt      420

gacctgttcc aactgctgag cgaccgtatc gcggttctgc acccggaagg tcacctgatt      480

accccgggct ggctgtggga gcgttatggt ctgcgtccgg aacagtgggt ggattttcgt      540

gcgctggcgg gtgacccgag cgataacatc ccgggcgtta aaggtattgg cgagaagacc      600

gcgctgaagc tgctgaaaga gtggggcagc ctggaaaaca tccagaaaaa cctggatcag      660

gtgaagccgg aacgtgttcg tgaggcgatt cgtaacaacc tggacaagct gcaaatgagt      720

ctggaactga gccgtctgcg taccgacctg ccgctggaag ttgatttccg tcgtcgtcgt      780

gaaccggatc gtgagggtct gcgtgcgttc ctggaacgtc tggagtttgg tagcctgctg      840

cacgaatttg gcctcttaga atcacccaag gccctggaag aagcactgtg gcctccacct      900

gaaggcgcct ttgttggttt tgttttgtct cgtaaagaac ctatgtgggc cgatttactg      960

gccttagccg ctgcacgtgg tggtcgtgtc catcgcgcac cagaacctta taaagcactg     1020

cgtgacctta aagaagctcg tggtctcctc gccaaagact tatccgtatt agcactccgc     1080

gagggtttag ggctgccacc tggtgatgat ccaatgttac ttgcatatct cctggatccc     1140

tctaatacaa ccccggaagg cgtggctcgt cgttatggtg gtgaatggac tgaagaagct     1200

ggtgaacgtg cggctttgtc tgaacgctta ttcgctaacc tgtggggccg tctggaagga     1260

gaggaacgct tactctggtt atatcgtgaa gttgaacgcc cactgtcagc agtacttgcg     1320

cacatggaag ctaccggggt ccgcttagat gttgcctatc tccgtgctct gagtcttgaa     1380

gtagccgaag aaattgcgcg cctggaagcc gaagtatttc gtctggcggg ccacccgttt     1440

aacctgaaca gccgtgacca gctggaacgt gttctgtttg atgaactggg tctgccgccg     1500

atcggcaaga ccgagaaaac cggtaaacgt agcaccagcg cggcggtgct ggaagcgctg     1560

cgtgaggcgc acccgatcgt tgagaagatt ctgcaatacc gtgaactggc gaagctgaaa     1620

agcacctata ttgacccgct gccgcgtctg gtgcacccga aaaccggtcg tctgcacacc     1680

cgtttcaacc aaaccgcgac cgcgaccggc cgtctgagca gcagcgatcc gaacctgcag     1740

aacatcccgg ttcgtacccc gctgggtcaa cgtatccgta aggcgtttat cgcagaagaa     1800

ggttggctgc tggtggcatt agattatagc caaattgaac tgcgtgttct ggcgcacctg     1860

agcggtgacg agaacctgat ccgtgtgttc cgtgaaggca aagatattca caccgagacc     1920

gcggcgtgga tgtttggtgt gccgccggaa ggtgttgatg gtgcgatgcg tcgtgcggcg     1980

aagaccgtga acttcggtgt tctgtatggc atgagcgcgc accgtctgag ccaggaactg     2040

agcatcccgt acgaagaggc ggcggcgttt attgagcgtt atttccagcg ctttccgcaa     2100

gtgcgtgcgt ggatcgcgca caccctggaa gagggtcgta agaaaggcta cgtggagacc     2160

ctgttcggtc gtcgtcgtta cgttccggac ctgaacgcgc gtgtgaaaag cgttcgtgaa     2220

gcagcggagc gtatggcgtt caacatggcg gtgcaaggta ccgcggcgga cctgatgaag     2280

ctggcgatgg tgaagctgtt tccgcgtctg ccggaagtgg gtgcgcgtat gctgctgcag     2340

gtgcacgatg aactgctgct ggaggcgccg aaagagcgtg cggaagaggc ggcggcgctg     2400

gcgaaggaag tgatggaggg tgtttggccg ctggcggtgc cgctggaagt ggaagttggt     2460

atcggtgaag actggctgag cgcgaagggc taa                                  2493


<210> 13
<211> 2493
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
atgctgccgc tgtttgagcc gaaaggtcgt gtgctgctgg ttgacggtca tcatctggcg       60

tatcgtaact tctttacgct gaaaggtctg accaccagcc gtggtgagcc tgtgcaaggt      120

gtttacggct tcgcgaaaag cctggcgaag gcgctgaaag aagacggcga tgtggttatc      180

gtggttttcg acgcgaaagc gccgagcttt cgtcacgagg cgtacggtgc gtataaagcg      240

ggtcgtgcgc cgaccccgga ggacttcccg cgtcagctgg cgctgatgaa ggaactggtg      300

gatctcctgg gtctggagcg tctggaagtt ccgggctttg aagcggatga tgttctggcg      360

gcgctggcga agatagcgga acgtgagggt tacgaagtgc gtattctgac cgcggaccgt      420

gacctgttcc aactgctgag cgaccgtatc gcggttctgc acccggaagg tcacctaatt      480

accccgggct ggctgtggga gcgttatggt ctgcgtccgg aacagtgggt gaattttcgt      540

gcgctggcgg gtgacccgag cgataacatc ccgggcgtta aaggtattgg cgagaagacc      600

acgctgaagc tgctgaaaga gtggggcagc ctggaaaaca tccagaaaaa cctggatcag      660

gtgaagccgg aacgtgttcg tgaggcgatt cgtaacaacc tggacaagct gcaaatgagc      720

ctggaactga gctgtctgcg taccgacctg ccgctggaag ttgatttccg tcgtcgtcgt      780

gaaccggatc gtgagggtct gcgtgcgttc ctggaacgtc tggagtttgg tagcctgctg      840

cacgaatttg gcctcttaga gtcacccaag gccctggaag aagcactgtg gcctccacct      900

gaaggcgcct ttgttggttt tgttttgtct cgtaaagaac ctatgtgggc cgatttactg      960

gccttagccg ctgcacgtgg tggtcgtgtc catcgcgcac cagaacctta taaagcactg     1020

cgtgatctta aagaagctcg tggtctcctc gccaaagact tatccgtatt agcactccgc     1080

gagggtttag ggctgccacc tggtgatgat ccaatgttac ttgcatatct cctggatccc     1140

tctaatacaa ccccggaagg cgtggctcgt cgttatggtg gtgaatggac tgaagaagct     1200

ggtgaacgtg cggctttgtc tgaacgctta ttcgctaacc tgtggggccg tctggaagga     1260

gaggaacgct tactctggtt atatcgtgaa gttgaacgcc cactgtcagc agtacttgcg     1320

cacatggaag ctaccggggt ccgcttagat gttgcctatc tccgtgctct gagtcttgaa     1380

gtagccgaag aaattgcgcg cctggaagcc gaagtatttc gtctggcggg ccacccgttt     1440

aacctgaaca gccgtgacca gctggaacgt gttctgtttg atgaactggg tctgccgccg     1500

atcggcagga ccgagaaaac cggtaaacgt agcaccagcg cggcggtgct ggaagcgctg     1560

cgtgaggcgc acccgatcgt tgagaagatt ctgcaatacc gtgaactggc gaagctgaaa     1620

agcacctata ttgacccgct gccgcgtctg gtgcacccga aaaccggtcg tctgcacacc     1680

cgtttcaacc aaaccgcgac cgcgaccggc cgtctgagca gcagcgatcc gaacctgcag     1740

aacatcccgg ttcgtacccc gctgggtcaa cgtatccgta aggcgtttat cgcagaagaa     1800

ggttggctgc tggtggcatt agattatagc caaattgaac tgcgtgttct ggcgcacctg     1860

agcggtgacg agaacctgat ccgtgtgttc cgtgaaggca aagatattca caccgagacc     1920

gcttcatgga tgtttggtgt tccgcgtgaa gccgtcgacc cgttaatgcg tcgcgctgca     1980

aaaaccatta attttggtgt tctgtatggt atgagcgcgc accgtctgag ccaggaactg     2040

agcatcccgt atgaagaggc ggtggcgttt attgagcgtt atttccagag ctttccgcaa     2100

gtgcgtgcgt ggatcgcgca caccctggaa gagggtcgta agaaaggcta cgtggagacc     2160

ctgttcggtc gtcgtcgtta cgttccggac ctgaacgcgc gtgtgaaaag cgttcgtgaa     2220

gcggcggagc gtatggcgtt caacatggcg gtgcaaggta ccgcggcgga cctgatgaag     2280

ctggcgatgg tgaagctgtt tccgcgtctg ccggaagtgg gtgcgcgtat gctgctgcag     2340

gtgcacgatg aactgctgct ggaggcgccg aaagagcgtg cggaagaggc ggcggcgctg     2400

gcgaaggaag tgatggaggg tgtttggccg ctggcggtgc cgctggaagt cgaagtgggc     2460

atcggtgaag actggctgtc ggcaaaagaa taa                                  2493


<210> 14
<211> 2502
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
tatgctgccg ctgtttgagc cgaaaggtcg tgtgctgctg gttgacggtc atcatctggc       60

gcatcgtaac ttcttcgcgc tgaaaggtct gaccaccagc cgtggtgagc cggtgcaagg      120

tgtttacggc ttcgcgaaaa gcctgctgaa ggcgctgaaa gaagacggcg atgtggttat      180

cgtggttttc gacgcgaaag cgccgagctt tcgtcacgag gcgtacggtg cgtataaagc      240

aggtcgtgcg ccgaccccgg aagacttccc gcgtcaactg gcgctgatta aggagctggt      300

tgatctgctg ggtctggtgc gtctggaagt gccgggcttt gaagcggatg atgtgctggc      360

gaccctggcg aagaaagcag aaaaagaagg atatgaagta cgcatcctga cagccgacaa      420

agacttatac caaatccttt cagatcgcgt ccacgtttta catcccgaag gctacttaat      480

tacccctgca tggctgtggg aaaaatatgg attacgtccg gatcaatggg ccgattaccg      540

tgctttaacc ggtgatgaat cagataacct gccagatgtt aaagggattg gagaaaaaac      600

tgcctgtaaa ttgttagatg aatggggctc tttggaagca ctgttaaaaa accttgatcg      660

tctcaaacct gccatccgcg aaaaaatcct ggcccacatg gatgacttaa aactgagctg      720

ggatcccgct aaagttcgta ccgacttacc tcttgaagtt gattttgcaa aacgccgtga      780

acctgatcgt gaacgccttc gtgcatttct tgaacgtctg gaatttggct ccttgttaca      840

tgaatttggc ctcttagaat cacccaaggc cctggaagaa gcactgtggc ctccacctga      900

aggcgccttt gttggttttg ttttgtctcg taaagaacct atgtgggccg atttactggc      960

attagccgct gcacgtggtg gtcgtgtcca tcgcgcacca gaaccttata aagcactgcg     1020

tgatcttaaa gaagctcgtg gtctcctcgc caaagactta tccgtattag cactccgcga     1080

gggtttaggg ctgccacctg gtgatgatcc aatgttactt gcatatctcc tggatccctc     1140

taatacaacc ccggaaggcg tggctcgtcg ttatggtggt gaatggactg aagaagctgg     1200

tgaacgtgcg gctttgtctg aacgcttatt cgctgacctg tggggccgtc tggaaggaga     1260

ggaacgctta ctctggttat atcgtgaagt tgaacgccca ctgtcagcag tacttgcgcg     1320

catggaagct accggggtcc gcttagatgt tgcctatctc cgtgctctga gtcttgaagt     1380

agccgaagaa attgcgcgcc tggaagccga agtatttcgt ctggccggtc acccgtttaa     1440

ccttaattcc cgtgatcaac tggaacgcgt tttgtttgat gaacttggcc tgcccgcaat     1500

tggtaaaact gaaaaaactg gtaaacgttc gacctccgcc gcagtccttg aagccctgcg     1560

tgaagcccac ccaattgtcg aaaaaatcct gcagtaccgg gaactcacga aacttaaatc     1620

tacctatatt gacccgctgc cgcgtctggt gcacccgaaa accggacgtc ttcacacccg     1680

ttttaatcaa actgctaccg cgactggacg tttaagctca tccgatccca acttgcaaaa     1740

tattcctgtc cgtaccccac tagggcaacg tattcgtaag gcgtttattg cggaagaggg     1800

ccacctgctg gttgcgctgg actacagcca gatcgaactg cgtgttctgg cgcacctgag     1860

cggtgacgag aacctgatcc gtgttttcca ggaaggcaaa gatattcaca ccgagaccgc     1920

ggcgtggatg tttggtgtgc cgccggaagg tgttgatggt gcgatgcgtc gtgcggcgaa     1980

gaccgtgaac ttcggtgttc tgtatggcat gagcgcgcac cgtctgagcc aggaactgag     2040

catcccgtac gaagaggcgg cggcgtttat tgagcgttat ttccagagct ttccgcaagt     2100

gcgtgcgtgg atcgcgcaca ccctggaaga gggtcgtaag aaaggctacg tggagaccct     2160

gttcggtcgt cgtcgttacg ttccggacct gaacgcgcgt gtgaaaagcg ttcgtaaagc     2220

ggcggagcgt atggcgttca acatggcggt gcaaggtacc gcggcggacc tgatgaagct     2280

ggcgatggtg aagctgtttc cgcgtctgcc ggaagtgggt gcgcgtatgc tgttgcaggt     2340

gcacgatgaa ctgctgctgg aggcgccgaa agagcgtgcg gaagaggcgg cggcgctggc     2400

gaaggaagtg atggagggtg tttggccgct tgcggtgccg ctggaagtgg aagttggtat     2460

cggtgaagac tggctgagcg cgaagggcta atatctaact aa                        2502


<210> 15
<211> 2490
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
atgctgccgc tgtttgagcc gaaaggtcgt gtgctgctgg ttgacggcca ccacctggcg       60

taccgtacct tctttgcgct gaaaggtctg accaccagcc gtggtgagcc ggtgcaaggt      120

gtttacggct tcgcgaaaag cctgctgaag gcgctgaaag aagacggcga ggtggcgatc      180

gtggttttcg atgcgaaagc gccgagcttt cgtcacgaag cgtacgaggc gtataaagcg      240

ggtcgtgcgc cgaccccgga agacttcccg cgtcaactgg cgctgattaa ggagctggtt      300

gatctgctgg gtctggtgcg tctggaagtg ccgggctttg aagcggatga tgttctggcg      360

gcgctggcga agaaagcgga acgtgagggt tacgaggttc gtatcctgag cgcggaccgt      420

gatctgtatc agctgctgag cgaccgtatt cacctactgc atcccgaagg ctacttaatt      480

acccctgcat ggctgtggga aaaatatgga ttacgtccgg atcaatgggc cgattaccgt      540

gctttaaccg gtgatgaatc agataacctg ccaggtgtta aagggattgg agaaaaaact      600

gcccgtaaat tgttagaaga atggggctct ttggaagcac tgttaaaaaa ccttgatcgt      660

ctcaaacctg ccatccgcga aaaaattctg gcccacatgg atgacttaaa actgagctgg      720

gatcccgcta aagttcgtac cgacttacct ctcgaagttg attttgcaaa acgccgtgaa      780

cctgatcgtg aacgccttcg tgcatttctt gaacgtctgg aatttggctc cttgttacac      840

gaatttggcc tcttagaatc acccaaggcc ctggaagaag caccgtggcc tccacctgaa      900

ggcgcctttg ttggttttgt tttgtctcgt aaagaaccta tgtgggccga tttactggcc      960

ttagccgctg cacgtggtgg tcgtgtccat cgcgcaccag aaccttataa agcactgcgt     1020

gatcttaaag aagctcgtgg tctcctcgcc aaagacttat ccgtattagc actccgcgag     1080

ggtttagggc tgccacctgg tgatgatcca atgttacttg catatctcct ggatccctct     1140

aatacaaccc cggaaggcgt ggctcgtcgt tatggtggtg aatggactga agaagctggt     1200

gaacgtgcgg ctttgtctga acgcttattc gctaacctgt ggggccgtct ggaaggagag     1260

gaacgcttac tctggttata tcgtgaagtt gaacgcccac tgtcagcagt acttgcgcac     1320

atggaagcta ccggggtccg cttagatgtt gcctatctcc gtgctctgag tcttgaagta     1380

gccgaagaaa ttgcgcgcct ggaagccgaa gtatttcgtc tggccggtca cccgttcaac     1440

cttaattccc gtgatcaact ggaacgcgtt ttgtttgatg aacttggcct gcccgcaatt     1500

ggtaaaactg aaaaaactgg taaacgttcg acctccgccg cagtccttga agccctgcgt     1560

gaagcccacc caattgtcga aaaaatcctg cagtaccgcg aactcactaa acttaaatct     1620

acctatattg acccgctgcc gcgtctggtg cacccgaaaa ccggacgtct tcacacccgt     1680

tttaatcaaa ctgctaccgc gactggacgt ttaagctcat ccgatcccaa cttgcaaaat     1740

attcctgtcc gtaccccact agggcaacgt attcgccgcg catttatcgc agaggaaggt     1800

tggttgctgg tggcattaga ttatagccaa attgaattac gtgttcttgc gcatttatcc     1860

ggtgacgaaa atctcattcg tgtttttcag gagggacgtg atattcacac agaaaccgct     1920

tcatggatgt ttggtgttcc gcgtgaagcc gtcgacccgt taatgcgtcg cgctgcaaaa     1980

accattaatt tcggtgttct gtatggtatg agtgcacatc ggttatcaca agaactcgct     2040

atcccgtacg aagaagctca agcatttatt gaacgttatt ttcagagttt tcctaaggtt     2100

cgtgcttgga ttgagcgtac cctggaagag ggtcgtcagc gtggctacgt ggaaaccctg     2160

tttggtcgtc gtcgttacgt tccggatctg aacgcgcgtg tgaaaagggt tcgtaaagcg     2220

gcggagcgta tggcgttcaa catgcaggtg caaggtaccg cggcggacct gatgaagctg     2280

gcgatggttc gtctgttccc gcgtctgccg gaagtgggtg cgcgtatgct gctgcaggtt     2340

cacgatgaac tgctgctgga ggcgccgaaa gagcgtgcgg aagaggcggc gcaactggcg     2400

aaggaaacca tggagggtgt ttggccgctg gcggtgccgc tggaagtcga agtgggcatc     2460

ggtgaagact ggctgtcggc aaaagaataa                                      2490


<210> 16
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 16
His His His His His His 
1               5       


<210> 17
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
gaaggtgaag gtcggagtc                                                    19


<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
gaagatggtg atgggatttc                                                   20


