                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Payne, Aimee S.
       Ellebrecht, Christoph T.
 
<120>  Compositions and Methods for Targeting Gamma Delta T Cells with 
       Chimeric Antigen Receptors

<130>  046483-7188WO1

<150>  US 62/619,146
<151>  2018-01-19

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  486
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  1

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ile Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Asn Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Tyr Ser Leu Thr Ile 
                85                  90                  95      


Lys Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Met Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly 
                165                 170                 175     


Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Ala Ser Gly Thr Thr Asp Tyr Asn Ser Ala Leu Met Ser 
        195                 200                 205             


Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Arg 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Glu Thr Thr Ala Ser Phe Gly Tyr Trp Gly Leu Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ala Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 


Cys Asp Ser Gly Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  2
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  3
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  3

Asp Ile Gln Met Thr Gln Thr Thr Ser Ile Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Asn Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Ser Leu Thr Ile Lys Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Met Val Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  4
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  4

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  5
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  5

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Ser Gly Thr Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Arg Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Thr Thr Ala Ser Phe Gly Tyr Trp Gly Leu Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  6
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  6

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ser Gly Ile 
        35                  40                  45              


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    50                  55                  60                  


Leu Val Ile Thr Leu Tyr Cys 
65                  70      


<210>  7
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  7

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  8
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  9
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgcgga       60

tccgatatcc aaatgacgca aactacgtct atcctgtctg cctccttggg cgaccgggtg      120

acgattacgt gccgggcatc tcaagatatt agtaactatc ttaactggta tcaacagaac      180

cctgacggaa cggtgaaatt gctcatttac tacacttcta gacttcatag tggcgtgccg      240

tccagatttt ccggaagtgg gtcaggtaca gaatactcac tgactattaa gaacctggaa      300

caagaggaca tagccacata tttttgtcag caaggtaata tggtcccttt taccttcggc      360

agtggtacta agctcgaaat aaagggagga gggggtagcg gaggtggcgg ctcaggcggc      420

ggcggcagtc aggttcaact taaggaatcc ggtcccggtc ttgtagcgcc aagtcagtct      480

ctctctatca cttgtacggt atccgggttc tcccttacgt cctacggggt acactgggtt      540

cgacaaccac ccggaaaggg cctggagtgg ttgggcgtca tatgggcaag cggaactacg      600

gattataact ctgcccttat gtctcgcctc accatttcta aagataatag taaaagccag      660

gtttttcttc gcatgaactc tctccaaact gatgacacag caatgtacta ctgcgccagg      720

gagactacag cgagtttcgg ttattggggc ttgggcacac tggtcacagt ttcagcagct      780

agcaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc      840

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg      900

ctggacttcg cctgtgattc cggaatctac atctgggccc ctctggccgg cacctgtggc      960

gtgctgctgc tgtccctggt catcaccctg tactgcaagc ggggcagaaa gaagctgctg     1020

tacatcttca agcagccctt catgcggcct gtgcagacca cacaggaaga ggacggctgt     1080

agctgtagat tccccgagga agaggaaggc ggctgcgagc tgagagtgaa gttcagcaga     1140

agcgccgacg cccctgccta tcagcagggc cagaaccagc tgtacaacga gctgaacctg     1200

ggcagacggg aggaatacga cgtgctggac aagagaagag gccgggaccc tgagatgggc     1260

ggcaagccca gacggaagaa cccccaggaa ggcctgtata acgaactgca gaaagacaag     1320

atggccgagg cctacagcga gatcggcatg aagggcgagc ggagaagagg caagggccat     1380

gacggcctgt accagggcct gagcaccgcc accaaggaca cctacgacgc cctgcacatg     1440

caggccctgc ctccaagatg a                                               1461


<210>  10
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  10
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgc          57


<210>  11
<211>  320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
gatatccaaa tgacgcaaac tacgtctatc ctgtctgcct ccttgggcga ccgggtgacg       60

attacgtgcc gggcatctca agatattagt aactatctta actggtatca acagaaccct      120

gacggaacgg tgaaattgct catttactac acttctagac ttcatagtgg cgtgccgtcc      180

agattttccg gaagtgggtc aggtacagaa tactcactga ctattaagaa cctggaacaa      240

gaggacatag ccacatattt ttgtcagcaa ggtaatatgg tcccttttac cttcggcagt      300

ggtactaagc tcgaaataaa                                                  320


<210>  12
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
gggaggaggg ggtagcggag gtggcggctc aggcggcggc ggcagt                      46


<210>  13
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
caggttcaac ttaaggaatc cggtcccggt cttgtagcgc caagtcagtc tctctctatc       60

acttgtacgg tatccgggtt ctcccttacg tcctacgggg tacactgggt tcgacaacca      120

cccggaaagg gcctggagtg gttgggcgtc atatgggcaa gcggaactac ggattataac      180

tctgccctta tgtctcgcct caccatttct aaagataata gtaaaagcca ggtttttctt      240

cgcatgaact ctctccaaac tgatgacaca gcaatgtact actgcgccag ggagactaca      300

gcgagtttcg gttattgggg cttgggcaca ctggtcacag tttcagca                   348


<210>  14
<211>  213
<212>  DNA
<213>  Homo sapiens

<400>  14
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgattccgg aatctacatc tgggcccctc tggccggcac ctgtggcgtg      180

ctgctgctgt ccctggtcat caccctgtac tgc                                   213


<210>  15
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  15
aagcggggca gaaagaagct gctgtacatc ttcaagcagc ccttcatgcg gcctgtgcag       60

accacacagg aagaggacgg ctgtagctgt agattccccg aggaagagga aggcggctgc      120

gagctg                                                                 126


<210>  16
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  16
agagtgaagt tcagcagaag cgccgacgcc cctgcctatc agcagggcca gaaccagctg       60

tacaacgagc tgaacctggg cagacgggag gaatacgacg tgctggacaa gagaagaggc      120

cgggaccctg agatgggcgg caagcccaga cggaagaacc cccaggaagg cctgtataac      180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg      240

agaagaggca agggccatga cggcctgtac cagggcctga gcaccgccac caaggacacc      300

tacgacgccc tgcacatgca ggccctgcct ccaaga                                336


<210>  17
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  17

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


