                         SEQUENCE LISTING

<110>  PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120>  GDF11 VARIANTS AND USES THEREOF

<130>  HRVY-124-WO1

<150>  62/619,683
<151>  2018-01-18

<150>  62/654,303
<151>  2018-04-06

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Leu Ala Ala Pro Leu Leu Leu Gly Phe Leu Leu Leu Ala Leu 
1               5                   10                  15      


Glu Leu Arg Pro Arg Gly Glu Ala Ala Glu Gly Pro Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Val Gly Gly Glu Arg Ser 
        35                  40                  45              


Ser Arg Pro Ala Pro Ser Val Ala Pro Glu Pro Asp Gly Cys Pro Val 
    50                  55                  60                  


Cys Val Trp Arg Gln His Ser Arg Glu Leu Arg Leu Glu Ser Ile Lys 
65                  70                  75                  80  


Ser Gln Ile Leu Ser Lys Leu Arg Leu Lys Glu Ala Pro Asn Ile Ser 
                85                  90                  95      


Arg Glu Val Val Lys Gln Leu Leu Pro Lys Ala Pro Pro Leu Gln Gln 
            100                 105                 110         


Ile Leu Asp Leu His Asp Phe Gln Gly Asp Ala Leu Gln Pro Glu Asp 
        115                 120                 125             


Phe Leu Glu Glu Asp Glu Tyr His Ala Thr Thr Glu Thr Val Ile Ser 
    130                 135                 140                 


Met Ala Gln Glu Thr Asp Pro Ala Val Gln Thr Asp Gly Ser Pro Leu 
145                 150                 155                 160 


Cys Cys His Phe His Phe Ser Pro Lys Val Met Phe Thr Lys Val Leu 
                165                 170                 175     


Lys Ala Gln Leu Trp Val Tyr Leu Arg Pro Val Pro Arg Pro Ala Thr 
            180                 185                 190         


Val Tyr Leu Gln Ile Leu Arg Leu Lys Pro Leu Thr Gly Glu Gly Thr 
        195                 200                 205             


Ala Gly Gly Gly Gly Gly Gly Arg Arg His Ile Arg Ile Arg Ser Leu 
    210                 215                 220                 


Lys Ile Glu Leu His Ser Arg Ser Gly His Trp Gln Ser Ile Asp Phe 
225                 230                 235                 240 


Lys Gln Val Leu His Ser Trp Phe Arg Gln Pro Gln Ser Asn Trp Gly 
                245                 250                 255     


Ile Glu Ile Asn Ala Phe Asp Pro Ser Gly Thr Asp Leu Ala Val Thr 
            260                 265                 270         


Ser Leu Gly Pro Gly Ala Glu Gly Leu His Pro Phe Met Glu Leu Arg 
        275                 280                 285             


Val Leu Glu Asn Thr Lys Arg Ser Arg Arg Asn Leu Gly Leu Asp Cys 
    290                 295                 300                 


Asp Glu His Ser Ser Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val 
305                 310                 315                 320 


Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr 
                325                 330                 335     


Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu Tyr Met Phe Met Gln Lys 
            340                 345                 350         


Tyr Pro His Thr His Leu Val Gln Gln Ala Asn Pro Arg Gly Ser Ala 
        355                 360                 365             


Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr 
    370                 375                 380                 


Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly Lys Ile Pro Gly Met Val 
385                 390                 395                 400 


Val Asp Arg Cys Gly Cys Ser 
                405         


<210>  2
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Glu Gly Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Gly Val Gly Gly Glu Arg Ser Ser Arg Pro Ala Pro Ser Val Ala 
            20                  25                  30          


Pro Glu Pro Asp Gly Cys Pro Val Cys Val Trp Arg Gln His Ser Arg 
        35                  40                  45              


Glu Leu Arg Leu Glu Ser Ile Lys Ser Gln Ile Leu Ser Lys Leu Arg 
    50                  55                  60                  


Leu Lys Glu Ala Pro Asn Ile Ser Arg Glu Val Val Lys Gln Leu Leu 
65                  70                  75                  80  


Pro Lys Ala Pro Pro Leu Gln Gln Ile Leu Asp Leu His Asp Phe Gln 
                85                  90                  95      


Gly Asp Ala Leu Gln Pro Glu Asp Phe Leu Glu Glu Asp Glu Tyr His 
            100                 105                 110         


Ala Thr Thr Glu Thr Val Ile Ser Met Ala Gln Glu Thr Asp Pro Ala 
        115                 120                 125             


Val Gln Thr Asp Gly Ser Pro Leu Cys Cys His Phe His Phe Ser Pro 
    130                 135                 140                 


Lys Val Met Phe Thr Lys Val Leu Lys Ala Gln Leu Trp Val Tyr Leu 
145                 150                 155                 160 


Arg Pro Val Pro Arg Pro Ala Thr Val Tyr Leu Gln Ile Leu Arg Leu 
                165                 170                 175     


Lys Pro Leu Thr Gly Glu Gly Thr Ala Gly Gly Gly Gly Gly Gly Arg 
            180                 185                 190         


Arg His Ile Arg Ile Arg Ser Leu Lys Ile Glu Leu His Ser Arg Ser 
        195                 200                 205             


Gly His Trp Gln Ser Ile Asp Phe Lys Gln Val Leu His Ser Trp Phe 
    210                 215                 220                 


Arg Gln Pro Gln Ser Asn Trp Gly Ile Glu Ile Asn Ala Phe Asp Pro 
225                 230                 235                 240 


Ser Gly Thr Asp Leu Ala Val Thr Ser Leu Gly Pro Gly Ala Glu Gly 
                245                 250                 255     


Leu His Pro Phe Met Glu Leu Arg Val Leu Glu Asn Thr Lys Arg Ser 
            260                 265                 270         


Arg Arg Asn Leu Gly Leu Asp Cys Asp Glu His Ser Ser Glu Ser Arg 
        275                 280                 285             


Cys Cys Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp 
    290                 295                 300                 


Trp Ile Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln 
305                 310                 315                 320 


Cys Glu Tyr Met Phe Met Gln Lys Tyr Pro His Thr His Leu Val Gln 
                325                 330                 335     


Gln Ala Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys 
            340                 345                 350         


Met Ser Pro Ile Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile 
        355                 360                 365             


Tyr Gly Lys Ile Pro Gly Met Val Val Asp Arg Cys Gly Cys Ser 
    370                 375                 380             


<210>  3
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  3

Asn Leu Gly Leu Asp Cys Asp Glu His Ser Ser Glu Ser Arg Cys Cys 
1               5                   10                  15      


Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile 
            20                  25                  30          


Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu 
        35                  40                  45              


Tyr Met Phe Met Gln Lys Tyr Pro His Thr His Leu Val Gln Gln Ala 
    50                  55                  60                  


Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser 
65                  70                  75                  80  


Pro Ile Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly 
                85                  90                  95      


Lys Ile Pro Gly Met Val Val Asp Arg Cys Gly Cys Ser 
            100                 105                 


<210>  4
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Glu Gly Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Gly Val Gly Gly Glu Arg Ser Ser Arg Pro Ala Pro Ser Val Ala 
            20                  25                  30          


Pro Glu Pro Asp Gly Cys Pro Val Cys Val Trp Arg Gln His Ser Arg 
        35                  40                  45              


Glu Leu Arg Leu Glu Ser Ile Lys Ser Gln Ile Leu Ser Lys Leu Arg 
    50                  55                  60                  


Leu Lys Glu Ala Pro Asn Ile Ser Arg Glu Val Val Lys Gln Leu Leu 
65                  70                  75                  80  


Pro Lys Ala Pro Pro Leu Gln Gln Ile Leu Asp Leu His Asp Phe Gln 
                85                  90                  95      


Gly Asp Ala Leu Gln Pro Glu Asp Phe Leu Glu Glu Asp Glu Tyr His 
            100                 105                 110         


Ala Thr Thr Glu Thr Val Ile Ser Met Ala Gln Glu Thr Asp Pro Ala 
        115                 120                 125             


Val Gln Thr Asp Gly Ser Pro Leu Cys Cys His Phe His Phe Ser Pro 
    130                 135                 140                 


Lys Val Met Phe Thr Lys Val Leu Lys Ala Gln Leu Trp Val Tyr Leu 
145                 150                 155                 160 


Arg Pro Val Pro Arg Pro Ala Thr Val Tyr Leu Gln Ile Leu Arg Leu 
                165                 170                 175     


Lys Pro Leu Thr Gly Glu Gly Thr Ala Gly Gly Gly Gly Gly Gly Arg 
            180                 185                 190         


Arg His Ile Arg Ile Arg Ser Leu Lys Ile Glu Leu His Ser Arg Ser 
        195                 200                 205             


Gly His Trp Gln Ser Ile Asp Phe Lys Gln Val Leu His Ser Trp Phe 
    210                 215                 220                 


Arg Gln Pro Gln Ser Asn Trp Gly Ile Glu Ile Asn Ala Phe Asp Pro 
225                 230                 235                 240 


Ser Gly Thr Asp Leu Ala Val Thr Ser Leu Gly Pro Gly Ala Glu Gly 
                245                 250                 255     


Leu His Pro Phe Met Glu Leu Arg Val Leu Glu Asn Thr Lys Arg Ser 
            260                 265                 270         


Arg Arg 
        


<210>  5
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
catgcaaaag tatccacaca cc                                                22


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6
cctggactgc gatgaacact                                                   20


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
cctactgagt tgtcagggga ac                                                22


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8
ctggaaggag agagggaaaa a                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
ctgcgcctag agagcatcaa g                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10
ttggaagtcg tgcagatcca g                                                 21


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
acagagcaac tggggaatcg                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12
agtgttcatc gcagtccagg                                                   20


<210>  13
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13
atcaagatca ttgctcctcc tgag                                              24


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14
ctgcttgctg atccacatct g                                                 21


<210>  15
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
tgggtgctca tgggagtaag acctgcagaa gcttggc                                37


<210>  16
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16
cttctgcagg tcttactccc atgagcaccc acagcgg                                37


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
aatacgactc actataggg                                                    19


<210>  18
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18
caggaaacag ctatgac                                                      17


<210>  19
<211>  6792
<212>  DNA
<213>  Homo sapiens

<400>  19
tccccgcccc ccagtcctcc cctcccctgc agcatggtgc tcgcggcccc gctgctgctg       60

ggcttcctgc tcctcgccct ggagctgcgg ccccgggggg aggcggccga gggccccgcg      120

gcggcggcgg cggcagcggc ggcggcggcc ggggtcgggg gggagcgctc gagccggccg      180

gccccgtccg ctccgccgga gccggacggc tgccccgtgt gcgtgtggcg gcagcacagc      240

cgcgagctgc gcctagagag catcaagtcg cagatcctga gcaaactgcg gctcaaggag      300

gcgcccaaca tcagccggga ggtagtgaag cagctgctgc ccaaggcgcc gccgctgcag      360

cagatcctgg atctgcacga cttccaaggc gacgcgctgc agcctgagga cttcttggaa      420

gaggacgagt accacgctac caccgagacg gtcataagca tggcccagga gagtaagtgg      480

gctgcggggt gcgcgcggtg cggtgcagtc cgggaaggac ccggaagccc tttctgcgaa      540

aacttgacgg attggggagc cgggccactc cacacaactt tttgagcgga gaagatgggc      600

agcggagttg agtgcacgcc ccgttctagg gtgggggggt ggaggatggc gcgttggggg      660

aggggggcca aaccaggcag gttgtgagct attgctttcc atcccttgtg agaaaaagat      720

tcaagttgaa gtagtcctag aaactggcac cctacagtga cttttctgga gcgttaggtg      780

gggagcttcc gtgacccgtg cagtctcagc tgggccgcag tgccatcttc ccactgctct      840

ggcaccagca tcaactcctt gcccggtgct ccggaaggcg cccaccggct ttcggaaaaa      900

ctaagtgttc ctctaaggcc atggcatagg acccaaaccc ggtgtacgtc tcagcaactc      960

agctgacacc tctcctttct gcacctgatc tcgcactggg tatcccctag gacctagaag     1020

agctgttcct tcctggtacc gaaagagctc aaataactca actccactgc gcttgccact     1080

taacgagtat catttggtta ctctcatctt agcgtgctca ctccctgtcc tacccacagc     1140

tggagccaaa gaagacccag ggagaaagaa ctagatgagg gggatgggag aacccaggca     1200

tccgagcccc tggccaaacg gaggatgaac actctgatag acaggagcgg ctttgaaatt     1260

ttatggcctg gaaaatccag gccaatacta ccgcccccac tgccttctct ccctagggtc     1320

aggtgactcc ctttcccctc ccccactgac tgtagtcccc ccccccccca actccaggga     1380

accaggcttt ctctattccc tagtggtttg gcaagccccc cctcctttgg ttttatggct     1440

ctgaacagaa gggggggctg gtttattggc agatgggtca taaaaagctg ggggttgcgg     1500

gaaatcctag tggcccaccc ccatggtaga ggtacaggaa cccaggtgtg catttggaag     1560

gttgagagcc tggcacttgc cacccagttt ctgcagaatt caactccaac ttggttagga     1620

ttgtaaagaa aactcagagt caggaaactc tctctctctc tctctctctc tctctctctc     1680

tctctctctc tctctctctc tctctctctc tctcgtgtgt atgtgtatgt gtatgtgtgt     1740

gagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgcacag agatctgatc ttgggttctc     1800

aggctccctt gttcttattg cttctacttt tggaaaccag ggtcagtctt tgattgacta     1860

agggcaggga tagggaaaag attctagaaa acagttgtag ggaaataatg aatgacaaaa     1920

ttttctggaa gatgcaggat atatagagaa aagatactct gctctgtgtg atgtaaagtg     1980

tgtatttcca gggtgagtga cccagctgca ggcttcccat tgccttcact atccctagcc     2040

tcctgtaacc agaaggcttg agtccagaat taactctggt agtggagagc agcaggaagt     2100

gaagggactc tgaatgcaca aattgggcag tagccattaa gcctgggggt gggattgtac     2160

cagtagatga agttgggtct caccctgact tccattttag tgccactcca ggacttaggt     2220

aacccaggaa ctgggtttca aaccaggtat tgtacttccc ctttaagagt ctagctgcga     2280

ccttaagaga gggaggggga gtagagggga ggggagggag agaggagagg ggggaaaagg     2340

aaaaagagac ttttatagtc taatccccag ggacccgctt taataagaga cttgtgctct     2400

gctaatcggg ggaggtgttt gtcagcagag atggcctctg ctcccctccc cctgcctccc     2460

ctcccccagc caaccccgga ccccagcccc cacctttcct aggctgttcg gcctgcccta     2520

gttccctcta ccctctcact ctcccacccc agccttcatc cctgggaacc cagccccctg     2580

ctcttctagg agccaagccc tgcccctcag tttgtctctc ctgtgcacgc taagaggccc     2640

ctgccctctc gcccaacctc ctgcccctgg gccatccagc ctgagttggg agagggtgtg     2700

tggtggggtg gaggctgtag gcagagaggg ggttgggcct ttgctgaaaa tagtgcagtg     2760

acctctctcc cccaccagca ccgcctccta aacctgacct gctgcctgcc accaaccaaa     2820

tcaatccaac acagatgtgg ccccttcccc tccccaccag agctccatag ctttacctgc     2880

ttctttgttc cttcttctgc acctttccat ctcttcttta ccccacgagg gtcccacctt     2940

tgccctctta ccttacccac tccagtccag tctacccagt gtttccattt cccaaacatt     3000

tgctcccatt actgtgatct acttgttccg ttcctctgct ggtcttggtc taacctgtct     3060

tcattctgtc tcttcattct tatcttatca tcttcaacct cttcctttcc ttacatcttg     3120

tcccctagaa acatgactgc agatacacag atgtatatgt ggattccctg gggcagcagt     3180

agaggaaccc ttgtccgaag gaagcagact taagaaggat atcccatgac cctgtctcag     3240

ccttaagtgg gatgtttagt ttataaaatg aacatttatt gggaaactat tattattttt     3300

catgttattt aatgcacaga attatttgta tgtccctcag aagtatagtg gctaaggtta     3360

agtaccaggc aacaacccag gcacatggtt aaacctttca ttgttgccag aagagtctgg     3420

gaagaacctg ccattcaaca tgtattcact gcttgacatg atgggagcca cagagaaact     3480

acaatggtga taaaatattc tcaggacatc aaccctcaca gagatgagta tctaatgaca     3540

aaaaaacaga taattcagct ggacctggtg gtaccagcat gtaatcccga ctactcagga     3600

gcctgaagca ggaatttatg aagtccaaag ccttcctgaa gtacagagta caaggccagc     3660

cttgggcaac cctgtctcaa aattaggaga aagagaatga agctcagggg tggggttctt     3720

gcctagcagg tgtgaggccc aaggtttgct ccccagtaac acgcacatga gtatgtgcat     3780

acacgcgctc acacgcacag ctgtgctgca atcagatgca gtgtgcatct aggcttactg     3840

tcacatccta atctctgcat ttccattcct catccgtatt ctaccttaca tgagtaagtg     3900

tcagaacact gggatcttgg atgctgcggg aggacatggt gtgtcctgtt ctgagtagtc     3960

agtacatact ttgttcctcg tcacactcag aggagtcctc ttcctggggt gatggagagc     4020

gttctccatg gcatggttat gcagatggta atacttgggt gtgacgacag ggacctggac     4080

ttcaccatta cttacacggc tctggaacaa cctcattcca gattcttcct atctagagaa     4140

tgaacaattt agggcatctc taacccactt aaagaggtca ggaaaagctg ggcatagtgg     4200

tacatgctgt aatctcaaca cctgggaaga tgagacagga gaactgctat gagctgagac     4260

tagcatgggc tatataggga cagtcagaga cacttaacaa acccatgtct caaaacaaag     4320

gctgagaaga gcttaaggaa agcaaatgga cacactgaga accttcctgg agactcctta     4380

ggatcttgaa ccatggaaag tggctaaaat gtaaagttgg gacgttaact ttgtaaagtt     4440

agaggcactg cattaagcaa acaaagggag gtcaagggag gagagatggc tgcttatagt     4500

tgacgcaatg tgttgaatat ggtttctgat actctgggca agaaggacac tctgaacttt     4560

cccttcctca gaagctgagt gtctccgctg gcagtgagga agcagcagag gacgcagaat     4620

ggggagtcag aatcacagga aatgcttggt agctccattc tgaagggcgt gctactggga     4680

atcaggagcc tggatctgct ctgacttact ttataaaccc atctctcagg accctgggtt     4740

atttcctctg atgcctcctt tgctttttca ggggagtggg ctgccaggct ccacctgctc     4800

attagatgaa ccgggtaagg tagcttgagg acagcaggtg cagcaaagag cattagagac     4860

cagctgagaa gcactggggc agggaaggcc tcagatggag gtagactcca cagctatctt     4920

agcagaggga tcctttgtgc taggagaaat gttatagggg atagtataga tcagtaaggc     4980

ctaacagact catcatccta gtgatgagac aattttaggt accagagaca taatagccaa     5040

caatacaggc acagaagggt aaagaggaat tggaaagcag gctgagaaga atctgctaaa     5100

gccaccgggg ctgctgaacc cctccctcca cagataccct tttctgatgt tgtgccccct     5160

tctctcttat cagcggaccc tgcagtgcag acagatggca gccctctctg ctgtcatttc     5220

cacttcagcc ccaaggtgat gttcaccaag gtactgaagg cccaactgtg ggtgtacctt     5280

cggcctgtgc cccgcccagc cacagtctac ctgcagatct tacgactgaa acccctaact     5340

ggggaaggga ccgcaggggg agggggtgga ggccggcgtc acatccgtat ccgttcacta     5400

aagattgagc tacactcacg ttccggccac tggcagagca tcgacttcaa gcaagtgcta     5460

cacagctggt ttcgccagcc acagagcaac tggggaatcg agatcaacgc ctttgatccc     5520

agcggcacag acctggctgt cacctccctg gggccaggag ctgaggggct ggtgagcagg     5580

gggcctgaag tggtggtgga ggatatgtat aacctgtccc caagagatgg gagttagaaa     5640

aagtagatca ggaatgtggt ggttggggcc aggaactaat ttcagaggag gtggggtagc     5700

aactatcact tttcagggat ttaagccaga tgacagctga aaactaaaac tggatttggg     5760

gtgaaggtat cagttagtgg gagatccgtg ggaacacaaa gctgaccctt gggcgtggtg     5820

ttatctaatc ctcgcagtag ggaggccaga caggagggcc aggagctcta gaccgttacc     5880

tttgctacat agcaaatctg aggtcaacct gagcgacatg agagcccatc tcaaaacaaa     5940

acagaacctg gcccttgaca aggcgctggg ccaagaaccc gatgaggtca cattgccaga     6000

aaaggaagaa ttagggaaag tgagcaggag agacgtctag atgtcaagag aagtgctcac     6060

aatgtctggg tgggagccgt aaacaagcca agaggttatg gtttctggtc tgatgctcct     6120

gttgagatca ggaaatgttc aggaaatccc ctgttgagat gtaggaaagt aagaggtaag     6180

agacattgtt gagggtcatg tcacatctct ttcccctctc cctgaccctc agcatccttt     6240

catggagctt cgagtcctag agaacacgaa aaggtcccgg cggaacctag gcctggactg     6300

cgatgaacac tcgagtgagt cccgctgctg ccgatatcct ctcacagtgg actttgaggc     6360

ttttggctgg gactggatca tcgcacctaa gcgctacaag gccaactact gctccggcca     6420

gtgcgaatac atgttcatgc aaaagtatcc acacacccac ttggtgcaac aggccaaccc     6480

aagaggctct gctgggccct gctgcacccc taccaagatg tccccaatca acatgctcta     6540

cttcaatgac aagcagcaga ttatctacgg caagatccct ggcatggtgg tggatcgatg     6600

tggctgctcc tgggagtaag cagagagccc tgccccaagc ctgtttttcc acagcaaggt     6660

gagaggcttg gtatagtttg ggggagttcc cctgacaact cagtaggagt aagtcagagt     6720

ccattcttag ctttttccct ctctccttcc agtagcagcc ggaagtggac cgaggatggg     6780

gcaaagtaag ga                                                         6792


