<110> 쾫׼＼޹˾
<120>һָĽڹCARǼеӦ
<160> 32
<170> PatentIn version 3.5
<210> 1
<211> 36
<212> PRT
<213> Artificial 
<220> 
<223> 7H
<400> 1
Ala Pro Pro Arg Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser
5 10 15
Ala Leu Pro Asp Pro Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro
20 25 30
Ala Ala Ser Ala Leu Pro
35
<210> 2
<211> 228
<212> PRT
<213> Artificial 
<220> 
<223> G4HH2H3mt
<400> 2
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro
5 10 15
Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
20 25 30
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
35 40 45
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
50 55 60
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
65 70 75
Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
80 85 90
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
95 100 105
Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala
110 115 120
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
125 130 135
Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
140 145 150
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
155 160 165
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
170 175 180
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys
185 190 195
Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His
200 205 210
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
215 220 225
Leu Gly Lys
<210> 3
<211> 45
<212> PRT
<213> Artificial 
<220> 
<223> 8H(dc)
<400> 3
Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
5 10 15
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Arg Pro
20 25 30
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Asp
35 40 45
<210> 4
<211> 229
<212> PRT
<213> Artificial 
<220> 
<223> G4HH2H3
<400> 4
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu
5 10 15
Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
20 25 30
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
35 40 45
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
50 55 60
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
65 70 75
Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
80 85 90
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
95 100 105
Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
110 115 120
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
125 130 135
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
140 145 150
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
155 160 165
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
170 175 180
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp
185 190 195
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met
200 205 210
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
215 220 225
Ser Leu Gly Lys

<210> 5
<211> 47
<212> PRT
<213> Artificial 
<220> 
<223> 8H
<400> 5
Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
5 10 15
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
20 25 30
Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
35 40 45
Cys Asp
<210> 6
<211> 236
<212> PRT
<213> Artificial 
<220> 
<223> PSCA-scFV
<400> 6
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
5 10 15
Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg
20 25 30
Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg
35 40 45
Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
50 55 60
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65 70 75
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp
80 85 90
Ser Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
95 100 105
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly
110 115 120
Ser Thr Lys Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly
125 130 135
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
140 145 150
Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Arg Gln Ala
155 160 165
Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp Pro Glu Asn
170 175 180
Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala Thr Ile
185 190 195
Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser
200 205 210
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly
215 220 225
Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
230 235
<210> 7
<211> 246
<212> PRT
<213> Artificial 
<220> 
<223> PSCA-scFV
<400> 7
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
5 10 15
Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Ser
20 25 30
Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
35 40 45
Leu Leu Ile Tyr Tyr Thr Leu Lys Leu Asn Ser Gly Val Pro Ser
50 55 60
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile
65 70 75
Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln
80 85 90
Ser Lys Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu
95 100 105
Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu
110 115 120
Gly Ser Thr Lys Gly Gln Val Lys Leu Gln Glu Ser Gly Gly Gly
125 130 135
Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Ala Ser
140 145 150
Gly Phe Thr Phe Ser Ser Tyr Thr Met Ser Trp Val Arg Arg Thr
155 160 165
Pro Glu Lys Arg Leu Glu Trp Val Ala Tyr Ile His Asn Gly Gly
170 175 180
Gly His Thr Tyr Tyr Pro Asp Thr Ile Lys Gly Arg Phe Thr Ile
185 190 195
Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe Leu Glu Met Ser Ser
200 205 210
Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Thr Arg Arg Met
215 220 225
Tyr Tyr Gly Asn Ser His Trp Tyr Phe Asp Val Trp Gly Ala Gly
230 235 240
Thr Ser Val Thr Val Ser
245
<210> 8
<211> 27
<212> PRT
<213> Artificial 
<220> 
<223> CD28TM
<400> 8
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
5 10 15
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
20 25
<210> 9
<211> 24
<212> PRT
<213> Artificial 
<220> 
<223> CD8 TM
<400> 9
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu
5 10 15
Leu Ser Leu Val Ile Thr Leu Tyr Cys
20
<210> 10
<211> 41
<212> PRT
<213> Artificial 
<220> 
<223> CD28
<400> 10
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
5 10 15
Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
20 25 30
Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
35 40
<210> 11
<211> 44
<212> PRT
<213> Artificial 
<220> 
<223> CD137
<400> 11
Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro
5 10 15
Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser
20 25 30
Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg
35 40
<210> 12
<211> 111
<212> PRT
<213> Artificial 
<220> 
<223> CD3
<400> 12
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
5 10 15
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
20 25 30
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
35 40 45
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu
50 55 60
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met
65 70 75
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
80 85 90
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
95 100 105
Gln Ala Leu Pro Pro Arg
110
<210> 13
<211> 496
<212> PRT
<213> Artificial 
<220> 
<223> PSCA-CAR-7H
<400> 13
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
5 10 15
Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg
20 25 30
Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg
35 40 45
Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
50 55 60
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65 70 75
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp
80 85 90
Ser Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
95 100 105
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly
110 115 120
Ser Thr Lys Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly
125 130 135
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
140 145 150
Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Arg Gln Ala
155 160 165
Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp Pro Glu Asn
170 175 180
Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala Thr Ile
185 190 195
Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser
200 205 210
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly
215 220 225
Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Pro Pro
230 235 240
Arg Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala Leu Pro
245 250 255
Asp Pro Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala Ser
260 265 270
Ala Leu Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
275 280 285
Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
290 295 300
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
305 310 315
Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
320 325 330
Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Val Lys Arg Gly
335 340 345
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro
350 355 360
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro
365 370 375
Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg
380 385 390
Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr
395 400 405
Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp
410 415 420
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg
425 430 435
Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys
440 445 450
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg
455 460 465
Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
470 475 480
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
485 490 495
<210> 14
<211> 452
<212> PRT
<213> Artificial 
<220> 
<223> PSCA-CAR1
<400> 14
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
5 10 15
Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg
20 25 30
Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg
35 40 45
Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
50 55 60
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65 70 75
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp
80 85 90
Ser Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
95 100 105
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly
110 115 120
Ser Thr Lys Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly
125 130 135
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
140 145 150
Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Arg Gln Ala
155 160 165
Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp Pro Glu Asn
170 175 180
Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala Thr Ile
185 190 195
Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser
200 205 210
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly
215 220 225
Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Pro Pro
230 235 240
Arg Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala Leu Pro
245 250 255
Asp Pro Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala Ser
260 265 270
Ala Leu Pro Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
275 280 285
Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Val Lys Arg
290 295 300
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg
305 310 315
Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
320 325 330
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser
335 340 345
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu
350 355 360
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu
365 370 375
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg
380 385 390
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp
395 400 405
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
410 415 420
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
425 430 435
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
440 445 450
<210> 15
<211> 452
<212> PRT
<213> Artificial 
<220> 
<223> PSCA-CAR2
<400> 15
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
5 10 15
Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg
20 25 30
Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg
35 40 45
Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
50 55 60
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65 70 75
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp
80 85 90
Ser Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
95 100 105
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly
110 115 120
Ser Thr Lys Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly
125 130 135
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
140 145 150
Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Arg Gln Ala
155 160 165
Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp Pro Glu Asn
170 175 180
Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala Thr Ile
185 190 195
Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser
200 205 210
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly
215 220 225
Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Pro Pro
230 235 240
Arg Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala Leu Pro
245 250 255
Asp Pro Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala Ser
260 265 270
Ala Leu Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
275 280 285
Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
290 295 300
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
305 310 315
Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
320 325 330
Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Val Lys Phe Ser
335 340 345
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu
350 355 360
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu
365 370 375
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg
380 385 390
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp
395 400 405
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
410 415 420
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
425 430 435
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
440 445 450
<210> 16
<211> 688
<212> PRT
<213> Artificial 
<220> 
<223> PSCA-CAR-G4HH2H3mt
<400> 16
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
5 10 15
Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg
20 25 30
Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg
35 40 45
Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
50 55 60
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65 70 75
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp
80 85 90
Ser Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
95 100 105
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly
110 115 120
Ser Thr Lys Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly
125 130 135
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
140 145 150
Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Arg Gln Ala
155 160 165
Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp Pro Glu Asn
170 175 180
Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala Thr Ile
185 190 195
Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser
200 205 210
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly
215 220 225
Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys
230 235 240
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly
245 250 255
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
260 265 270
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
275 280 285
Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
290 295 300
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln
305 310 315
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
320 325 330
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
335 340 345
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
350 355 360
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu
365 370 375
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
380 385 390
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
395 400 405
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
410 415 420
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp
425 430 435
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
440 445 450
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
455 460 465
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
470 475 480
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
485 490 495
Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
500 505 510
Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
515 520 525
Arg Asp Phe Ala Ala Tyr Arg Ser Val Lys Arg Gly Arg Lys Lys
530 535 540
Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr
545 550 555
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
560 565 570
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp
575 580 585
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu
590 595 600
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg
605 610 615
Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro
620 625 630
Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu
635 640 645
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys
650 655 660
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp
665 670 675
Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
680 685
<210> 17
<211> 644
<212> PRT
<213> Artificial 
<220> 
<223> PSCA-CAR3
<400> 17
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
5 10 15
Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg
20 25 30
Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg
35 40 45
Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
50 55 60
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65 70 75
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp
80 85 90
Ser Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
95 100 105
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly
110 115 120
Ser Thr Lys Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly
125 130 135
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
140 145 150
Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Arg Gln Ala
155 160 165
Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp Pro Glu Asn
170 175 180
Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala Thr Ile
185 190 195
Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser
200 205 210
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly
215 220 225
Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys
230 235 240
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly
245 250 255
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
260 265 270
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
275 280 285
Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
290 295 300
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln
305 310 315
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
320 325 330
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
335 340 345
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
350 355 360
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu
365 370 375
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
380 385 390
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
395 400 405
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
410 415 420
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp
425 430 435
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
440 445 450
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
455 460 465
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu
470 475 480
Leu Ser Leu Val Ile Thr Leu Tyr Cys Val Lys Arg Gly Arg Lys
485 490 495
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
500 505 510
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu
515 520 525
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala
530 535 540
Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu
545 550 555
Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg
560 565 570
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn
575 580 585
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala
590 595 600
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly
605 610 615
Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys
620 625 630
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
635 640
<210> 18
<211> 644
<212> PRT
<213> Artificial 
<220> 
<223> PSCA-CAR4
<400> 18
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
5 10 15
Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg
20 25 30
Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg
35 40 45
Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
50 55 60
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65 70 75
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp
80 85 90
Ser Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
95 100 105
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly
110 115 120
Ser Thr Lys Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly
125 130 135
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
140 145 150
Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Arg Gln Ala
155 160 165
Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp Pro Glu Asn
170 175 180
Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala Thr Ile
185 190 195
Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser
200 205 210
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly
215 220 225
Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys
230 235 240
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly
245 250 255
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
260 265 270
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
275 280 285
Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
290 295 300
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln
305 310 315
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
320 325 330
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
335 340 345
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
350 355 360
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu
365 370 375
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
380 385 390
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
395 400 405
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
410 415 420
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp
425 430 435
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
440 445 450
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
455 460 465
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
470 475 480
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
485 490 495
Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
500 505 510
Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
515 520 525
Arg Asp Phe Ala Ala Tyr Arg Ser Val Lys Phe Ser Arg Ser Ala
530 535 540
Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu
545 550 555
Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg
560 565 570
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn
575 580 585
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala
590 595 600
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly
605 610 615
Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys
620 625 630
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
635 640
<210> 19
<211> 63
<212> DNA
<213> Artificial 
<220> 
<223>ǰ
<400> 19
atggcactgc cagtgaccgc cctgctgctg cccctggcac tgctgctgca cgcagctcgg 60
cct 63
<210> 20
<211> 684
<212> DNA
<213> Artificial 
<220> 
<223> G4HH2H3mt
<400> 20
gaaagcaaat atggcccgcc gtgcccgccg tgcccggcgc cgccggtggc gggcccgagc 60
gtgtttctgt ttccgccgaa accgaaagat accctgatga ttagccgcac cccggaagtg 120
acctgcgtgg tggtggatgt gagccaggaa gatccggaag tgcagtttaa ctggtatgtg 180
gatggcgtgg aagtgcataa cgcgaaaacc aaaccgcgcg aagaacagtt tcagagcacc 240
tatcgcgtgg tgagcgtgct gaccgtgctg catcaggatt ggctgaacgg caaagaatat 300
aaatgcaaag tgagcaacaa aggcctgccg agcagcattg aaaaaaccat tagcaaagcg 360
aaaggccagc cgcgcgaacc gcaggtgtat accctgccgc cgagccagga agaaatgacc 420
aaaaaccagg tgagcctgac ctgcctggtg aaaggctttt atccgagcga tattgcggtg 480
gaatgggaaa gcaacggcca gccggaaaac aactataaaa ccaccccgcc ggtgctggat 540
agcgatggca gcttttttct gtatagccgc ctgaccgtgg ataaaagccg ctggcaggaa 600
ggcaacgtgt ttagctgcag cgtgatgcat gaagcgctgc ataaccatta tacccagaaa 660
agcctgagcc tgagcctggg caaa 684
<210> 21
<211> 108
<212> DNA
<213> Artificial 
<220> 
<223> 7H
<400> 21
gcgccgccgc gcgcgagcgc gctgccggcg ccgccgaccg gcagcgcgct gccggatccg 60
cagaccgcga gcgcgctgcc ggatccgccg gcggcgagcg cgctgccg 108
<210> 22
<211> 30
<212> DNA
<213> Artificial 
<220> 
<223>
<400> 22
atcgctagca tggccctgcc agtgaccgcc 30
<210> 23
<211> 31
<212> DNA
<213> Artificial 
<220> 
<223>
<400> 23
ccaggtcgac ttagcgaggg ggcagggcct g 31
<210> 24
<211> 1485
<212> DNA
<213> Artificial 
<220> 
<223> PSCA-CAR -7H
<400> 24
gatattcagc tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc 60
attacctgca gcgcgagcag cagcgtgcgc tttattcatt ggtatcagca gaaaccgggc 120
aaagcgccga aacgcctgat ttatgatacc agcaaactgg cgagcggcgt gccgagccgc 180
tttagcggca gcggcagcgg caccgatttt accctgacca ttagcagcct gcagccggaa 240
gattttgcga cctattattg ccagcagtgg agcagcagcc cgtttacctt tggccagggc 300
accaaagtgg aaattaaagg cagcaccagc ggcagcggca aaccgggcag cggcgaaggc 360
agcaccaaag gcagcgaagt gcagctggtg gaaagcggcg gcggcctggt gcagccgggc 420
ggcagcctgc gcctgagctg cgcggcgagc ggctttaaca ttaaagatta ttatattcat 480
tgggtgcgcc aggcgccggg caaaggcctg gaatgggtgg cgtggattga tccggaaaac 540
ggcgataccg aatttgtgcc gaaatttcag ggccgcgcga ccattagcgc ggataccagc 600
aaaaacaccg cgtatctgca gatgaacagc ctgcgcgcgg aagataccgc ggtgtattat 660
tgcaaaaccg gcggcttttg gggccagggc accctggtga ccgtgagcag cgcgccgccg 720
cgcgcgagcg cgctgccggc gccgccgacc ggcagcgcgc tgccggatcc gcagaccgcg 780
agcgcgctgc cggatccgcc ggcggcgagc gcgctgccgt tttgggtgct ggtggtggtg 840
ggcggcgtgc tggcgtgcta tagcctgctg gtgaccgtgg cgtttattat tttttgggtg 900
cgcagcaaac gcagccgcct gctgcatagc gattatatga acatgacccc gcgccgcccg 960
ggcccgaccc gcaaacatta tcagccgtat gcgccgccgc gcgattttgc ggcgtatcgc 1020
agcgtgaaac gcggccgcaa aaaactgctg tatattttta aacagccgtt tatgcgcccg 1080
gtgcagacca cccaggaaga agatggctgc agctgccgct ttccggaaga agaagaaggc 1140
ggctgcgaac tgcgcgtgaa atttagccgc agcgcggatg cgccggcgta tcagcagggc 1200
cagaaccagc tgtataacga actgaacctg ggccgccgcg aagaatatga tgtgctggat 1260
aaacgccgcg gccgcgatcc ggaaatgggc ggcaaaccgc gccgcaaaaa cccgcaggaa 1320
ggcctgtata acgaactgca gaaagataaa atggcggaag cgtatagcga aattggcatg 1380
aaaggcgaac gccgccgcgg caaaggccat gatggcctgt atcagggcct gagcaccgcg 1440
accaaagata cctatgatgc gctgcatatg caggcgctgc cgccgcgc 1488

<210> 25
<211> 2061
<212> DNA
<213> Artificial 
<220> 
<223> PSCA-CAR CG4HH2H3mt
<400> 25
gatattcagc tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc 60
attacctgca gcgcgagcag cagcgtgcgc tttattcatt ggtatcagca gaaaccgggc 120
aaagcgccga aacgcctgat ttatgatacc agcaaactgg cgagcggcgt gccgagccgc 180
tttagcggca gcggcagcgg caccgatttt accctgacca ttagcagcct gcagccggaa 240
gattttgcga cctattattg ccagcagtgg agcagcagcc cgtttacctt tggccagggc 300
accaaagtgg aaattaaagg cagcaccagc ggcagcggca aaccgggcag cggcgaaggc 360
agcaccaaag gcagcgaagt gcagctggtg gaaagcggcg gcggcctggt gcagccgggc 420
ggcagcctgc gcctgagctg cgcggcgagc ggctttaaca ttaaagatta ttatattcat 480
tgggtgcgcc aggcgccggg caaaggcctg gaatgggtgg cgtggattga tccggaaaac 540
ggcgataccg aatttgtgcc gaaatttcag ggccgcgcga ccattagcgc ggataccagc 600
aaaaacaccg cgtatctgca gatgaacagc ctgcgcgcgg aagataccgc ggtgtattat 660
tgcaaaaccg gcggcttttg gggccagggc accctggtga ccgtgagcag cgaaagcaaa 720
tatggcccgc cgtgcccgcc gtgcccggcg ccgccggtgg cgggcccgag cgtgtttctg 780
tttccgccga aaccgaaaga taccctgatg attagccgca ccccggaagt gacctgcgtg 840
gtggtggatg tgagccagga agatccggaa gtgcagttta actggtatgt ggatggcgtg 900
gaagtgcata acgcgaaaac caaaccgcgc gaagaacagt ttcagagcac ctatcgcgtg 960
gtgagcgtgc tgaccgtgct gcatcaggat tggctgaacg gcaaagaata taaatgcaaa 1020
gtgagcaaca aaggcctgcc gagcagcatt gaaaaaacca ttagcaaagc gaaaggccag 1080
ccgcgcgaac cgcaggtgta taccctgccg ccgagccagg aagaaatgac caaaaaccag 1140
gtgagcctga cctgcctggt gaaaggcttt tatccgagcg atattgcggt ggaatgggaa 1200
agcaacggcc agccggaaaa caactataaa accaccccgc cggtgctgga tagcgatggc 1260
agcttttttc tgtatagccg cctgaccgtg gataaaagcc gctggcagga aggcaacgtg 1320
tttagctgca gcgtgatgca tgaagcgctg cataaccatt atacccagaa aagcctgagc 1380
ctgagcctgg gcaaattttg ggtgctggtg gtggtgggcg gcgtgctggc gtgctatagc 1440
ctgctggtga ccgtggcgtt tattattttt tgggtgcgca gcaaacgcag ccgcctgctg 1500
catagcgatt atatgaacat gaccccgcgc cgcccgggcc cgacccgcaa acattatcag 1560
ccgtatgcgc cgccgcgcga ttttgcggcg tatcgcagcg tgaaacgcgg ccgcaaaaaa 1620
ctgctgtata tttttaaaca gccgtttatg cgcccggtgc agaccaccca ggaagaagat 1680
ggctgcagct gccgctttcc ggaagaagaa gaaggcggct gcgaactgcg cgtgaaattt 1740
agccgcagcg cggatgcgcc ggcgtatcag cagggccaga accagctgta taacgaactg 1800
aacctgggcc gccgcgaaga atatgatgtg ctggataaac gccgcggccg cgatccggaa 1860
atgggcggca aaccgcgccg caaaaacccg caggaaggcc tgtataacga actgcagaaa 1920
gataaaatgg cggaagcgta tagcgaaatt ggcatgaaag gcgaacgccg ccgcggcaaa 1980
ggccatgatg gcctgtatca gggcctgagc accgcgacca aagataccta tgatgcgctg 2040
catatgcagg cgctgccgcc gcgc 2064
<210> 26
<211> 244
<212> PRT
<213> Artificial 
<220> 
<223> scFV-2
<400> 26
Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
5 10 15
Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser 
20 25 30
Ser Tyr Thr Met Ser Trp Val Arg Arg Thr Pro Glu Lys Arg Leu 
35 40 45
Glu Trp Val Ala Tyr Ile His Asn Gly Gly Gly His Thr Tyr Tyr 
50 55 60
Pro Asp Thr Ile Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
65 70 75
Lys Asn Thr Leu Phe Leu Glu Met Ser Ser Leu Lys Ser Glu Asp 
80 80 90
Thr Ala Met Tyr Tyr Cys Thr Arg Arg Met Tyr Tyr Gly Asn Ser 
95 100 105
His Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Ser Val Thr Val 
110	115	120
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
125	130	135
Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
140	145	150
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp 
155	160 165
Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
170	175	180
Pro Lys Leu Leu Ile Tyr Tyr Thr Leu Lys Leu Asn Ser Gly Val 
185	190	195
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe 
200	205	210
Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
215	220	225
Gln Gln Ser Lys Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys 
230	235	240
Val Glu Ile Lys
<210> 27
<211> 233
<212> PRT
<213> Artificial 
<220> 
<223> scFV-3
<400> 27
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
5 10 15
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys
20 25 30
Asp Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
35 40 45
Glu Trp Val Ala Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Phe
50 55 60
Val Pro Lys Phe Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser
65 70 75
Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
80 85 90
Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly Phe Trp Gly Gln Gly
95 100 105
Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
110	115	120
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro
125	130	135
Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
140	145	150
Ser Ala Ser Ser Ser Val Arg Phe Ile His Trp Tyr Gln Gln Lys
155	160	165
Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Asp Thr Ser Lys Leu
170	175	180
Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
185	190	195
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala
200	205	210
Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ser Pro Phe Thr Phe Gly
215	220	225
Gln Gly Thr Lys Val Glu Ile Lys
230
<210> 28
<211> 505
<212> PRT
<213> Artificial 
<220> 
<223> PSCA-CAR-8H(dc)
<400> 28
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
5	10	15
Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg
20	25	30
Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg
35	40	45
Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
50	55	60
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65	70	75
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp
80	85	90
Ser Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
95	100	105
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly
110	115	120
Ser Thr Lys Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly
125	130	135
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
140	145	150
Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Arg Gln Ala
155	160	165
Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp Pro Glu Asn
170	175	180
Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala Thr Ile
185	190	195
Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser
200	205	210
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly
215	220	225
Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Lys Pro Thr
230	235	240
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
245	250	255
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Arg Pro Ala Ala Gly
260	265	270
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Asp Phe Trp Val
275	280	285
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
290	295	300
Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
305	310	315
Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
320	325	330
Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
335	340	345
Ala Ala Tyr Arg Ser Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr
350	355	360
Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu
365	370	375
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly
380	385	390
Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala
395	400	405
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly
410	415	420
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp
425	430	435
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly
440	445	450
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser
455	460	465
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp
470	475	480
Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp
485	490	495
Ala Leu His Met Gln Ala Leu Pro Pro Arg
500	505
<210> 29
<211> 461
<212> PRT
<213> Artificial 
<220> 
<223> PSCA-CAR1
<400> 29
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
5  10	15
Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg
20	25	30
Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg
35	40	45
Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
50	55	60
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65	70	75
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp
80	85	90
Ser Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
95 100 105
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly
110	115	120
Ser Thr Lys Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly
125	130	135
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
140	145	150
Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Arg Gln Ala
155	160	165
Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp Pro Glu Asn
170	175	180
Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala Thr Ile
185	190	195
Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser
200	205	210
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly
215	220	225
Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Lys Pro Thr
230	235	240
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
245	250	255
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Arg Pro Ala Ala Gly
260	265	270
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Asp Ile Tyr Ile
275	280	285
Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu
290	295	300
Val Ile Thr Leu Tyr Cys Val Lys Arg Gly Arg Lys Lys Leu Leu
305	310	315
Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln
320	325	330
Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly
335	340	345
Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro
350	355	360
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
365	370	375
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
380	385	390
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu
395	400	405
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr
410	415	420
Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His
425	430	435
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr
440	445	450
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
455	 460
<210> 30
<211> 461
<212> PRT
<213> Artificial 
<220> 
<223> PSCA-CAR2
<400> 30
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
5	10	15
Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg
20	25	30
Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg
35	40	45
Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg
50	55	60
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65	70	75
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp
80 85 90
Ser Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
95 100	105
Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly
110	115	120
Ser Thr Lys Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly
125	130	135
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
140	145	150
Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Arg Gln Ala
155	160	165
Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp Pro Glu Asn
170	175	180
Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala Thr Ile
185	190	195
Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser
200	205	210
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly
215	220	225
Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Lys Pro Thr
230	235	240
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
245	250	255
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Arg Pro Ala Ala Gly
260	265	270
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Asp Phe Trp Val
275	280	285
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
290	295	300
Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
305	310	315
Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
320	325	330
Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
335	340	345
Ala Ala Tyr Arg Ser Val Lys Phe Ser Arg Ser Ala Asp Ala Pro
350	355	360
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
365	370	375
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
380	385	390
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu
395	400	405
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr
410	415	420
Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His
425	430	435
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr
440	445	450
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
455	460
<210> 31
<211> 1515
<212> DNA
<213> Artificial 
<220> 
<223> PSCA-CAR -8H(dc)
<400> 31
gatattcagc tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60
attacctgca gcgcgagcag cagcgtgcgc tttattcatt ggtatcagca gaaaccgggc     120
aaagcgccga aacgcctgat ttatgatacc agcaaactgg cgagcggcgt gccgagccgc     180
tttagcggca gcggcagcgg caccgatttt accctgacca ttagcagcct gcagccggaa     240
gattttgcga cctattattg ccagcagtgg agcagcagcc cgtttacctt tggccagggc     300
accaaagtgg aaattaaagg cagcaccagc ggcagcggca aaccgggcag cggcgaaggc     360
agcaccaaag gcagcgaagt gcagctggtg gaaagcggcg gcggcctggt gcagccgggc     420
ggcagcctgc gcctgagctg cgcggcgagc ggctttaaca ttaaagatta ttatattcat     480
tgggtgcgcc aggcgccggg caaaggcctg gaatgggtgg cgtggattga tccggaaaac     540
ggcgataccg aatttgtgcc gaaatttcag ggccgcgcga ccattagcgc ggataccagc     600
aaaaacaccg cgtatctgca gatgaacagc ctgcgcgcgg aagataccgc ggtgtattat     660
tgcaaaaccg gcggcttttg gggccagggc accctggtga ccgtgagcag caaaccgacc     720
accaccccgg cgccgcgccc gccgaccccg gcgccgacca ttgcgagcca gccgctgagc     780
ctgcgcccgg aagcgcgccc ggcggcgggc ggcgcggtgc atacccgcgg cctggatttt     840
gcggattttt gggtgctggt ggtggtgggc ggcgtgctgg cgtgctatag cctgctggtg     900
accgtggcgt ttattatttt ttgggtgcgc agcaaacgca gccgcctgct gcatagcgat     960
tatatgaaca tgaccccgcg ccgcccgggc ccgacccgca aacattatca gccgtatgcg    1020
ccgccgcgcg attttgcggc gtatcgcagc gtgaaacgcg gccgcaaaaa actgctgtat    1080
atttttaaac agccgtttat gcgcccggtg cagaccaccc aggaagaaga tggctgcagc    1140
tgccgctttc cggaagaaga agaaggcggc tgcgaactgc gcgtgaaatt tagccgcagc    1200
gcggatgcgc cggcgtatca gcagggccag aaccagctgt ataacgaact gaacctgggc    1260
cgccgcgaag aatatgatgt gctggataaa cgccgcggcc gcgatccgga aatgggcggc    1320
aaaccgcgcc gcaaaaaccc gcaggaaggc ctgtataacg aactgcagaa agataaaatg    1380
gcggaagcgt atagcgaaat tggcatgaaa ggcgaacgcc gccgcggcaa aggccatgat    1440
ggcctgtatc agggcctgag caccgcgacc aaagatacct atgatgcgct gcatatgcag    1500
gcgctgccgc cgcgc  
<210> 32
<211> 135
<212> DNA
<213> Artificial 
<220> 
<223> 8H(dc)
<400>32
aaaccgacca ccaccccggc gccgcgcccg ccgaccccgg cgccgaccat tgcgagccag      60
ccgctgagcc tgcgcccgga agcgcgcccg gcggcgggcg gcgcggtgca tacccgcggc     120
ctggattttg cggat                                                      135
