                         SEQUENCE LISTING

<110>  Integrated DNA Technologies, Inc.
       Collingwood, Michael A
       Jacobi, Ashley M
       Rettig, Garret R
       Schubert, Mollie S
       Behlke, Mark A
       Vakulskas, Christopher A
 
<120>  CRISPR-BASED COMPOSITIONS AND METHODS OF USE

<130>  IDT01-008-PCT-CIP

<140>  PCT/US18/15583
<141>  2018-01-26

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLETIDE

<400>  1
cuuauaucca acacuucgug guuuuagagc uaugcu                                 36


<210>  2
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-SpC3 spacer (propanediol)

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  3'-SpC3 spacer (propanediol)

<400>  2
cuuauaucca acacuucgug guuuuagagc uaugcu                                 36


<210>  3
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotoide linkage

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  locked nucleic acid  internucleotoide linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  phosphorothioate internucleotoide linkage

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  2'-O-methyl moiety

<400>  3
cuuauaucca acacuucgug guuuuagagc uaugcu                                 36


<210>  4
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (24)..(36)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (34)..(36)
<223>  phosphorothioate internucleotide linkage

<400>  4
cuuauaucca acacuucgug guuuuagagc uaugcu                                 36


<210>  5
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA-DNA SEQUENCE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (33)..(35)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  2'-O-methyl moiety

<400>  5
cuuauaucca acacuucgug guuuuagagc uatgcu                                 36


<210>  6
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA SEQUENCE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  2'-O-methyl moiety

<400>  6
cuuauaucca acacuucgug guuuuagagc uaugcu                                 36


<210>  7
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONULCEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (31)..(33)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  2'-O-methyl moiety

<400>  7
cuuauaucca acacuucgug guuuuagagc uaugcu                                 36


<210>  8
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA-DNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (33)..(35)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  2'-O-methyl

<400>  8
cuuauaucca acacuucgug guuuuagagc uatgcu                                 36


<210>  9
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (97)..(99)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (98)..(100)
<223>  phosphorothioate internucleotide linkage

<400>  9
cuuauaucca acacuucgug guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  10
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-SpC3 spacer (propanediol)

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  3'-SpC3 spacer (propanediol)

<400>  10
gaggcuauuc ugcccauuug guuuuagagc uaugcu                                 36


<210>  11
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA SEQUENCE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  2'-O-methyl moiety

<400>  11
gaggcuauuc ugcccauuug guuuuagagc uaugcu                                 36


<210>  12
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA-DNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (33)..(35)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  2'-O-methyl moiety

<400>  12
gaggcuauuc ugcccauuug guuuuagagc uatgcu                                 36


<210>  13
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (97)..(99)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (98)..(100)
<223>  phosphorothioate internucleotide linkage

<400>  13
gaggcuauuc ugcccauuug guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  14
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-SpC3 (propanediol)

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  3'-SpC3 (propanediol)

<400>  14
uggcacugag cucccagauc guuuuagagc uaugcu                                 36


<210>  15
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  2'-O-methyl moiety

<400>  15
uggcacugag cucccagauc guuuuagagc uaugcu                                 36


<210>  16
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA-DNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (33)..(35)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  2'-O-methyl moiety

<400>  16
uggcacugag cucccagauc guuuuagagc uatgcu                                 36


<210>  17
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (97)..(99)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (98)..(100)
<223>  phosphorothioate internucleotide linkage

<400>  17
uggcacugag cucccagauc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  18
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-SpC3 (propanediol)

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  3'-SpC3 (propanediol)

<400>  18
aggacaaguu cucugaguuc guuuuagagc uaugcu                                 36


<210>  19
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  2'-O-methyl moiety

<400>  19
aggacaaguu cucugaguuc guuuuagagc uaugcu                                 36


<210>  20
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA-DNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (32)..(34)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  2'-O-methyl moiety

<400>  20
aggacaaguu cucugaguuc guuuuagagc atgcu                                  35


<210>  21
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (97)..(99)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (98)..(100)
<223>  phosphorothioate internucleotide linkage

<400>  21
aggacaaguu cucugaguuc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  22
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-SpC3 spacer (propanediol)

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  3'-SpC3 spacer (propanediol)

<400>  22
ccccuccaac cuggaauucc guuuuagagc uaugcu                                 36


<210>  23
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  2'-O-methyl moiety

<400>  23
ccccuccaac cuggaauucc guuuuagagc uaugcu                                 36


<210>  24
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA-DNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorthioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (33)..(35)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  phosphorthioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  2'-O-methyl moiety

<400>  24
ccccuccaac cuggaauucc guuuuagagc uatgcu                                 36


<210>  25
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (97)..(99)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (98)..(100)
<223>  phosphorothioate internucleotide linkage

<400>  25
ccccuccaac cuggaauucc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  26
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-SpC3 spacer (propanediol)

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  3'-SpC3 spacer (propanediol)

<400>  26
gcugcuguag cugauuccau guuuuagagc uaugcu                                 36


<210>  27
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  2'-O-methyl moiety

<400>  27
gcugcuguag cugauuccau guuuuagagc uaugcu                                 36


<210>  28
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA-DNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (33)..(35)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  2'-O-methyl moiety

<400>  28
gcugcuguag cugauuccau guuuuagagc uatgcu                                 36


<210>  29
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (97)..(99)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (98)..(100)
<223>  phosphorothioate internucleotide linkage

<400>  29
gcugcuguag cugauuccau guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  30
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-SpC3 spacer (propanediol)

<220>
<221>  misc_feature
<222>  (1)..(1)

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  3'-SpC3 spacer (propanediol)

<400>  30
cuuauaucca acacuucgug guuuuagagc uaugcu                                 36


<210>  31
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (34)..(36)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (34)..(36)
<223>  phosphorothioate internucleotide linkage

<400>  31
cuuauaucca acacuucgug guuuuagagc uaugcu                                 36


<210>  32
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (24)..(36)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (34)..(36)
<223>  phosphorothioate internucleotide linkage

<400>  32
cuuauaucca acacuucgug guuuuagagc uaugcu                                 36


<210>  33
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (38)..(67)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (66)..(67)
<223>  phosphorothioate internucleotide linkage

<400>  33
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugcuuu                                                                 67


<210>  34
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE

<400>  34
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugcuuu                                                                 67


<210>  35
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC AMINO ACID SEQUENCE

<400>  35

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  36
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE

<400>  36
cuuauaucca acacuucgug guuuuagagc uaugcuguuu ug                          42


<210>  37
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE

<400>  37
cuuauaucca acacuucgug guuuuagagc uaugcu                                 36


<210>  38
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE

<400>  38
guuggaacca uucaaaacag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga       60

aaaaguggca ccgagucggu gcuuuuuuu                                         89


<210>  39
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE

<400>  39
cuuauaucca acacuucgug guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuu                              99


<210>  40
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (26)..(36)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (34)..(36)
<223>  phosphorothioate internucleotide linkage

<400>  40
cuuauaucca acacuucgug guuuuagagc uaugcu                                 36


<210>  41
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  locked nucleic acid  internucleotide linkage

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl moiety

<400>  41
guuuuagagc uaugcu                                                       16


<210>  42
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA-DNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl moiety

<400>  42
guuuuagagc uuatgcu                                                      17


<210>  43
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl moiety

<400>  43
guuuuagagc uaugcu                                                       16


<210>  44
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl moiety

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  locked nucleic acid internucleotide linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl moiety

<400>  44
guuuuagagc uaugcu                                                       16


<210>  45
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE

<400>  45
ggugagugag ugugugcgug guuuuagagc uaugcu                                 36


<210>  46
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA OLIGONUCLEOTIDE


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-SpC3 Spacer (propanediol)

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  3'-SpC3 Spacer (propanediol)

<400>  46
ggugagugag ugugugcgug guuuuagagc uaugcu                                 36


<210>  47
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC RNA SEQUENCE


<220>
<221>  misc_feature
<222>  (2)..(7)
<223>  phosphorothioate internucleotide linkage

<220>
<221>  misc_feature
<222>  (31)..(36)
<223>  phosphorothioate internucleotide linkage

<400>  47
ggugagugag ugugugcgug guuuuagagc uaugcu                                 36


<210>  48
<211>  8068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC DNA OLIGONUCLEOTIDE

<400>  48
ggggaattgt gagcggataa caattcccct gtagaaataa ttttgtttaa ctttaataag       60

gagatatacc atggacaaaa agtactctat tggcctggat atcgggacca acagcgtcgg      120

gtgggctgtt atcaccgacg agtataaagt accttcgaaa aagttcaaag tgctgggcaa      180

caccgatcgc cattcaatca aaaagaactt gattggtgcg ctgttgtttg actccgggga      240

aaccgccgag gcgactcgcc ttaaacgtac agcacgtcgc cggtacactc ggcgtaagaa      300

tcgcatttgc tatttgcagg aaatctttag caacgagatg gcaaaagtcg atgactcgtt      360

tttccaccgc ctcgaggaaa gctttctggt ggaggaagac aaaaagcatg agcgtcaccc      420

gatcttcggc aacattgtcg atgaagtagc gtatcatgaa aaatacccaa ccatttacca      480

cttacgcaaa aagctggtgg acagcactga caaagctgat ttgcgcctta tctatttagc      540

cctggcacat atgattaagt ttcgtggtca cttcctgatc gaaggagact taaatcccga      600

caacagtgat gttgataaat tgtttattca gcttgtccaa acttacaatc aactgttcga      660

ggaaaacccg atcaatgcct ccggtgtgga tgcaaaagcc attttaagtg cacgccttag      720

caagtcccgt cgcttagaaa accttatcgc gcagctgccc ggcgagaaaa agaatggttt      780

gtttgggaac cttattgcct tgagcttagg cctcaccccg aatttcaaaa gtaatttcga      840

tcttgcagaa gacgccaaat tacaactgtc gaaggatact tatgatgacg atctcgataa      900

tctgttagcg cagattggtg accaatacgc cgatcttttt ctggcggcta aaaatctgag      960

cgacgccatc ttgctttcgg atattctccg cgttaacacc gaaatcacga aagcgcctct     1020

tagtgccagc atgattaaac gttatgatga acaccaccag gacctgacct tactcaaagc     1080

gttggttcgc cagcaactgc cagagaagta caaagaaatc ttctttgatc agtcaaagaa     1140

tggttatgcc ggctatattg acgggggtgc aagccaagag gaattctaca aatttatcaa     1200

gcctattctg gagaaaatgg atggcaccga agagttattg gtgaagctta accgtgaaga     1260

cctcctgcgg aaacagcgca cattcgataa tggttcgatc ccacaccaaa tccatttggg     1320

ggagttacac gctattttgc gtcgccagga agacttttac cctttcctga aggataaccg     1380

ggagaaaatt gagaagatcc ttacctttcg tattccgtat tacgtaggcc ccttagcacg     1440

gggtaatagc cgtttcgcgt ggatgacacg gaagtcggaa gagacgatca ccccgtggaa     1500

cttcgaagag gtagtcgaca agggcgcatc agcgcagtct tttattgaac gtatgacgaa     1560

tttcgataaa aacttgccca atgagaaggt gcttccgaaa cattccttgt tatatgaata     1620

ttttacagtt tacaacgagc tgaccaaggt taaatacgtg acggaaggaa tgcgcaagcc     1680

cgcttttctt agcggtgagc aaaaaaaggc gatcgtcgac ctgttattca aaacgaatcg     1740

taaggtgact gtaaagcaac tcaaagaaga ttacttcaaa aagattgagt gcttcgacag     1800

cgtcgaaatc tctggggtag aggatcggtt taacgcaagt ttaggtacct accatgacct     1860

gcttaaaatc attaaggata aagacttctt agataatgaa gagaacgaag atattctcga     1920

ggacatcgtc ttgacgttaa ccttatttga ggatcgtgaa atgattgagg aacgcctcaa     1980

aacttatgcc cacctgttcg acgataaggt gatgaagcag ctgaaacgtc ggcgctacac     2040

aggatggggc cgcttgagtc gcaaacttat taacggaatc cgtgacaagc aatccggcaa     2100

aacgattctg gatttcttga agtcggacgg atttgctaat cgcaacttca tgcagttgat     2160

ccatgatgac tccctgactt ttaaagagga tattcaaaag gcgcaggtta gtggtcaagg     2220

cgacagctta cacgaacaca tcgcaaattt ggctggttcg ccggccatta aaaaggggat     2280

cctccagacc gtgaaagttg tagatgagct tgttaaggtc atgggtcgtc ataagcccga     2340

aaacatcgtg attgaaatgg cgcgggagaa tcaaacgacc cagaaaggac aaaagaatag     2400

ccgtgaacgg atgaagcgga tcgaggaagg cattaaagag ctggggtctc aaatcttgaa     2460

ggaacaccct gtggagaaca ctcagctcca aaatgaaaaa ctttacctgt actatttgca     2520

gaacggacgc gatatgtacg tggaccaaga gttggatatt aatcggctga gtgactacga     2580

cgttgatcat atcgtcccgc agagcttcct caaagacgat tctattgaca ataaggtact     2640

gacgcgctct gataaaaacc gtggtaagtc ggacaacgtg ccctccgaag aggttgtgaa     2700

aaagatgaaa aattattggc gccagctttt aaacgcgaag ctgatcacac aacgtaaatt     2760

cgataatttg accaaggctg aacggggtgg cctgagcgag ttagataagg caggatttat     2820

taaacgccag ttagtggaga ctcgtcaaat caccaaacat gtcgcgcaga ttttggacag     2880

ccggatgaac accaagtacg atgaaaatga caaactgatc cgtgaggtga aagtcattac     2940

tctgaagtcc aaattagtta gtgatttccg gaaggacttt caattctaca aagtccgtga     3000

aattaataac tatcatcacg cacatgacgc gtacctgaat gcagtggttg ggaccgccct     3060

tatcaagaaa tatcctaagc tggagtcgga gtttgtctat ggcgactata aggtatacga     3120

tgttcgcaaa atgattgcga aatctgagca ggagatcggt aaggcaaccg caaaatattt     3180

cttttactca aacattatga atttctttaa gacagaaatc actctggcca acggggagat     3240

tcgcaaacgt ccgttgatcg aaacaaacgg cgagactggc gaaattgttt gggacaaagg     3300

gcgtgatttc gcgacggtgc gcaaggtact gagcatgcct caagtcaata ttgttaagaa     3360

aaccgaagtg cagacgggcg ggttttccaa ggaaagcatc ttacccaaac gtaattcaga     3420

taaacttatt gcacgcaaaa aggactggga tccgaaaaag tatggaggct tcgacagtcc     3480

aaccgtagcc tactctgttc tcgttgtagc gaaagtagaa aagggtaaat ccaagaaact     3540

gaaatctgtc aaggagttgc ttggaatcac cattatggag cgtagctcct tcgagaagaa     3600

cccgattgac tttctggaag ccaaaggata taaagaggtc aagaaagatc ttatcattaa     3660

gctgcctaag tattcactct tcgagctgga aaatggtcgt aaacgcatgc tcgcttctgc     3720

cggcgagttg cagaagggca atgaattagc acttccatca aagtacgtta acttcctgta     3780

tttggccagc cattacgaga aactgaaggg gtctccagag gacaacgaac agaaacaatt     3840

atttgtagag cagcacaagc attatcttga tgaaatcatt gagcaaattt ccgaattcag     3900

taaacgcgta atcctggccg atgcaaacct cgacaaggtg ctgagcgctt acaataagca     3960

tcgcgacaaa cctatccgtg agcaggctga aaatatcatt cacctgttca cattaacgaa     4020

cctgggcgct ccggccgctt ttaaatattt cgacacgaca atcgaccgta agcgctatac     4080

cagtacgaaa gaagtgttgg atgcgaccct tattcaccag tcaattacag gattatatga     4140

gacccgtatc gaccttagcc aattaggtgg ggattaagag ctcggcgcgc ctgcaggtcg     4200

acaagcttgc ggccgcataa tgcttaagtc gaacagaaag taatcgtatt gtacacggcc     4260

gcataatcga aattaatacg actcactata ggggaattgt gagcggataa caattcccca     4320

tcttagtata ttagttaagt ataagaagga gatatacata tggcagatct caattggata     4380

tcggccggcc acgcgatcgc tgacgtcggt accctcgagt ctggtaaaga aaccgctgct     4440

gcgaaatttg aacgccagca catggactcg tctactagcg cagcttaatt aacctaggct     4500

gctgccaccg ctgagcaata actagcataa ccccttgggg cctctaaacg ggtcttgagg     4560

ggttttttgc tgaaacctca ggcatttgag aagcacacgg tcacactgct tccggtagtc     4620

aataaaccgg taaaccagca atagacataa gcggctattt aacgaccctg ccctgaaccg     4680

acgaccgggt cgaatttgct ttcgaatttc tgccattcat ccgcttatta tcacttattc     4740

aggcgtagca ccaggcgttt aagggcacca ataactgcct taaaaaaatt acgccccgcc     4800

ctgccactca tcgcagtact gttgtaattc attaagcatt ctgccgacat ggaagccatc     4860

acagacggca tgatgaacct gaatcgccag cggcatcagc accttgtcgc cttgcgtata     4920

atatttgccc atagtgaaaa cgggggcgaa gaagttgtcc atattggcca cgtttaaatc     4980

aaaactggtg aaactcaccc agggattggc tgagacgaaa aacatattct caataaaccc     5040

tttagggaaa taggccaggt tttcaccgta acacgccaca tcttgcgaat atatgtgtag     5100

aaactgccgg aaatcgtcgt ggtattcact ccagagcgat gaaaacgttt cagtttgctc     5160

atggaaaacg gtgtaacaag ggtgaacact atcccatatc accagctcac cgtctttcat     5220

tgccatacgg aactccggat gagcattcat caggcgggca agaatgtgaa taaaggccgg     5280

ataaaacttg tgcttatttt tctttacggt ctttaaaaag gccgtaatat ccagctgaac     5340

ggtctggtta taggtacatt gagcaactga ctgaaatgcc tcaaaatgtt ctttacgatg     5400

ccattgggat atatcaacgg tggtatatcc agtgattttt ttctccattt tagcttcctt     5460

agctcctgaa aatctcgata actcaaaaaa tacgcccggt agtgatctta tttcattatg     5520

gtgaaagttg gaacctctta cgtgccgatc aacgtctcat tttcgccaaa agttggccca     5580

gggcttcccg gtatcaacag ggacaccagg atttatttat tctgcgaagt gatcttccgt     5640

cacaggtatt tattcggcgc aaagtgcgtc gggtgatgct gccaacttac tgatttagtg     5700

tatgatggtg tttttgaggt gctccagtgg cttctgtttc tatcagctgt ccctcctgtt     5760

cagctactga cggggtggtg cgtaacggca aaagcaccgc cggacatcag cgctagcgga     5820

gtgtatactg gcttactatg ttggcactga tgagggtgtc agtgaagtgc ttcatgtggc     5880

aggagaaaaa aggctgcacc ggtgcgtcag cagaatatgt gatacaggat atattccgct     5940

tcctcgctca ctgactcgct acgctcggtc gttcgactgc ggcgagcgga aatggcttac     6000

gaacggggcg gagatttcct ggaagatgcc aggaagatac ttaacaggga agtgagaggg     6060

ccgcggcaaa gccgtttttc cataggctcc gcccccctga caagcatcac gaaatctgac     6120

gctcaaatca gtggtggcga aacccgacag gactataaag ataccaggcg tttcccctgg     6180

cggctccctc gtgcgctctc ctgttcctgc ctttcggttt accggtgtca ttccgctgtt     6240

atggccgcgt ttgtctcatt ccacgcctga cactcagttc cgggtaggca gttcgctcca     6300

agctggactg tatgcacgaa ccccccgttc agtccgaccg ctgcgcctta tccggtaact     6360

atcgtcttga gtccaacccg gaaagacatg caaaagcacc actggcagca gccactggta     6420

attgatttag aggagttagt cttgaagtca tgcgccggtt aaggctaaac tgaaaggaca     6480

agttttggtg actgcgctcc tccaagccag ttacctcggt tcaaagagtt ggtagctcag     6540

agaaccttcg aaaaaccgcc ctgcaaggcg gttttttcgt tttcagagca agagattacg     6600

cgcagaccaa aacgatctca agaagatcat cttattaatc agataaaata tttctagatt     6660

tcagtgcaat ttatctcttc aaatgtagca cctgaagtca gccccatacg atataagttg     6720

taattctcat gttagtcatg ccccgcgccc accggaagga gctgactggg ttgaaggctc     6780

tcaagggcat cggtcgagat cccggtgcct aatgagtgag ctaacttaca ttaattgcgt     6840

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg     6900

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgcca gggtggtttt tcttttcacc     6960

agtgagacgg gcaacagctg attgcccttc accgcctggc cctgagagag ttgcagcaag     7020

cggtccacgc tggtttgccc cagcaggcga aaatcctgtt tgatggtggt taacggcggg     7080

atataacatg agctgtcttc ggtatcgtcg tatcccacta ccgagatgtc cgcaccaacg     7140

cgcagcccgg actcggtaat ggcgcgcatt gcgcccagcg ccatctgatc gttggcaacc     7200

agcatcgcag tgggaacgat gccctcattc agcatttgca tggtttgttg aaaaccggac     7260

atggcactcc agtcgccttc ccgttccgct atcggctgaa tttgattgcg agtgagatat     7320

ttatgccagc cagccagacg cagacgcgcc gagacagaac ttaatgggcc cgctaacagc     7380

gcgatttgct ggtgacccaa tgcgaccaga tgctccacgc ccagtcgcgt accgtcttca     7440

tgggagaaaa taatactgtt gatgggtgtc tggtcagaga catcaagaaa taacgccgga     7500

acattagtgc aggcagcttc cacagcaatg gcatcctggt catccagcgg atagttaatg     7560

atcagcccac tgacgcgttg cgcgagaaga ttgtgcaccg ccgctttaca ggcttcgacg     7620

ccgcttcgtt ctaccatcga caccaccacg ctggcaccca gttgatcggc gcgagattta     7680

atcgccgcga caatttgcga cggcgcgtgc agggccagac tggaggtggc aacgccaatc     7740

agcaacgact gtttgcccgc cagttgttgt gccacgcggt tgggaatgta attcagctcc     7800

gccatcgccg cttccacttt ttcccgcgtt ttcgcagaaa cgtggctggc ctggttcacc     7860

acgcgggaaa cggtctgata agagacaccg gcatactctg cgacatcgta taacgttact     7920

ggtttcacat tcaccaccct gaattgactc tcttccgggc gctatcatgc cataccgcga     7980

aaggttttgc gccattcgat ggtgtccggg atctcgacgc tctcccttat gcgactcctg     8040

cattaggaaa ttaatacgac tcactata                                        8068


