
                                SEQUENCE LISTING

<110> Adagene Inc.
      LUO, Peter Peizhi
      DU, Fangyong
      PAN, Zhongzong

<120> ACTIVATABLE BINDING POLYPEPTIDES AND
      METHODS OF MAKING AND USING THE SAME
  
<130> 695402000640

<140> Not Yet Assigned
<141> Concurrently Herewith

<160> 87

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1, 3
<223> Xaa = Ala, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu,
Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp, or Tyr

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Asp, Ala, Tyr, Ser, Thr, Asn, Ile, Leu, Phe, Val,
His, and Pro

<220> 
<221> VARIANT        
<222> 1
<223> Can be present in repeats of at least three and up to 10

<220> 
<221> VARIANT        
<222> 3
<223> Can be present in repeats of at least three and up to 10

<220> 
<221> VARIANT        
<222> 5
<223> Can be present in repeats of at least one and up to 10

<400> 1
Xaa Cys Xaa Cys Xaa
 1               5  


<210> 2
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1, 2, 7, 8, 13
<223> n = A,T,C or G

<220> 
<221> misc_feature   
<222> 3, 9
<223> n = A,T,C or G

<220> 
<221> misc_feature   
<222> 6, 12
<223> n = T or C

<220> 
<221> misc_feature   
<222> 14
<223> n = A,T or C

<220> 
<221> misc_feature   
<222> 1, 2, 3
<223> Can be present in repeats of at least three and up to 10

<220> 
<221> misc_feature   
<222> 7, 8, 9
<223> Can be present in repeats of at least three and up to 10

<220> 
<221> misc_feature   
<222> 13, 14, 15
<223> Can be present in repeats of at least one and up to 10

<400> 2
nnntgnnnnt gnnnc                                                  15

<210> 3
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Ala, Asp, Ile, Asn, Pro, or Tyr

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Ala, Phe, Asn, Ser, or Val

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = Ala, His, Leu, Pro, Ser, Val, or Tyr

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = Ala, His, Ser, or Tyr

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = Ala, Asp, Pro, Ser, Val, or Tyr

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = Ala, Asp, Leu, Ser, or Tyr

<220> 
<221> VARIANT        
<222> 13
<223> Xaa = Asp, Pro, or Val

<220> 
<221> VARIANT        
<222> 14
<223> Xaa = Ala, Asp, His, Pro, Ser, or Thr

<220> 
<221> VARIANT        
<222> 15
<223> Xaa = Ala, Asp, Phe, His, Pro, or Tyr

<220> 
<221> VARIANT        
<222> 16
<223> Xaa = Leu, Pro, or Tyr

<220> 
<221> VARIANT        
<222> 17
<223> Xaa = Phe, Pro, or Tyr

<220> 
<221> VARIANT        
<222> 18
<223> Xaa = Ala, Pro, Ser, or Tyr

<220> 
<221> VARIANT        
<222> 20
<223> Xaa = Ala, Asp, Asn, Ser, Thr, or Tyr

<220> 
<221> VARIANT        
<222> 21
<223> Xaa = Ala, Ser, or Tyr

<400> 3
Glu Val Gly Ser Tyr Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa
 1               5                  10                  15      
Xaa Xaa Cys Xaa Xaa Ser Gly Arg Ser Ala Gly Gly Gly Gly Thr Glu
            20                  25                  30          
Asn Leu Tyr Phe Gln Gly Ser Gly Gly Ser
        35                  40          


<210> 4
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 6, 8, 10
<223> Xaa = Asp, Ala, Tyr, Ser, Thr, Asn, Ile, Leu, Phe, Val, His, and Pro

<220> 
<221> VARIANT        
<222> 6
<223> Present in repeats of six

<220> 
<221> VARIANT        
<222> 8
<223> Present in repeats of six

<220> 
<221> VARIANT        
<222> 10
<223> Present in repeats of two

<400> 4
Glu Val Gly Ser Tyr Xaa Cys Xaa Cys Xaa Ser Gly Arg Ser Ala
 1               5                  10                  15  


<210> 5
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 6, 10
<223> Xaa = Asp, Ala, Tyr, Ser, Thr, Asn, Ile, Leu, Phe, Val, His, and Pro

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = Ala, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
Pro, Gln, Arg, Ser, Thr, Val, Trp, and Tyr

<220> 
<221> VARIANT        
<222> 6
<223> Present in repeats of six

<220> 
<221> VARIANT        
<222> 8
<223> Present in repeats of six

<220> 
<221> VARIANT        
<222> 10
<223> Present in repeats of two

<400> 5
Glu Val Gly Ser Tyr Xaa Cys Xaa Cys Xaa Ser Gly Arg Ser Ala
 1               5                  10                  15  


<210> 6
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 6, 8, 10
<223> Xaa = Asp, Ala, Tyr, Ser, Thr, Asn, Ile, Leu, Phe, Val, His, and Pro

<220> 
<221> VARIANT        
<222> 6
<223> Present in repeats of six

<220> 
<221> VARIANT        
<222> 8
<223> Present in repeats of eight

<220> 
<221> VARIANT        
<222> 10
<223> Present in repeats of two

<400> 6
Glu Val Gly Ser Tyr Xaa Cys Xaa Cys Xaa Ser Gly Arg Ser Ala
 1               5                  10                  15  


<210> 7
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 6, 10
<223> Xaa = Asp, Ala, Tyr, Ser, Thr, Asn, Ile, Leu, Phe, Val, His, and Pro

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = Ala, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
Pro, Gln, Arg, Ser, Thr, Val, Trp, and Tyr

<220> 
<221> VARIANT        
<222> 6
<223> Present in repeats of six

<220> 
<221> VARIANT        
<222> 8
<223> Present in repeats of eight

<220> 
<221> VARIANT        
<222> 10
<223> Present in repeats of two

<400> 7
Glu Val Gly Ser Tyr Xaa Cys Xaa Cys Xaa Ser Gly Arg Ser Ala
 1               5                  10                  15  


<210> 8
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 16, 22, 28
<223> n = A,T,C or G

<220> 
<221> misc_feature   
<222> 17, 23, 29
<223> n = A,T, or C

<220> 
<221> misc_feature   
<222> 16, 17, 18
<223> Present in repeats of six

<220> 
<221> misc_feature   
<222> 22, 23, 24
<223> Present in repeats of six

<220> 
<221> misc_feature   
<222> 28, 29, 30
<223> Present in repeats of two

<400> 8
gaggttggat cctacnnctg tnnctgcnnc tcaggtcgtt ccgct                 45

<210> 9
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 16, 22, 23, 28
<223> n = A,T,C or G

<220> 
<221> misc_feature   
<222> 17, 29
<223> n = A,T, or C

<220> 
<221> misc_feature   
<222> 16, 17, 18
<223> Present in repeats of six

<220> 
<221> misc_feature   
<222> 22, 23, 24
<223> Present in repeats of six

<220> 
<221> misc_feature   
<222> 28, 29, 30
<223> Present in repeats of two

<400> 9
gaggttggat cctacnnctg tnnntgcnnc tcaggtcgtt ccgct                 45

<210> 10
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 16, 22, 28
<223> n = A,T,C or G

<220> 
<221> misc_feature   
<222> 17, 23, 29
<223> n = A,T, or C

<220> 
<221> misc_feature   
<222> 16, 17, 18
<223> Present in repeats of six

<220> 
<221> misc_feature   
<222> 22, 23, 24
<223> Present in repeats of eight

<220> 
<221> misc_feature   
<222> 28, 29, 30
<223> Present in repeats of two

<400> 10
gaggttggat cctacnnctg tnnctgcnnc tcaggtcgtt ccgct                 45

<210> 11
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 16, 22, 23, 28
<223> n = A,T,C or G

<220> 
<221> misc_feature   
<222> 17, 29
<223> n = A,T, or C

<220> 
<221> misc_feature   
<222> 16, 17, 18
<223> Present in repeats of six

<220> 
<221> misc_feature   
<222> 22, 23, 24
<223> Present in repeats of eight

<220> 
<221> misc_feature   
<222> 28, 29, 30
<223> Present in repeats of two

<400> 11
gaggttggat cctacnnctg tnnntgcnnc tcaggtcgtt ccgct                 45

<210> 12
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly
 1               5                  10                  15      
Ser Gly Gly Ser
            20  


<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 13
Ser Gly Arg Ser Ala
 1               5  


<210> 14
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
Pro Leu Gly Leu Ala Gly
 1               5      


<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
Glu Asn Leu Tyr Phe Gln Gly
 1               5          


<210> 16
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
Glu Val Gly Ser Tyr
 1               5  


<210> 17
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
Gly Gly Gly Gly Ser
 1               5  


<210> 18
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 18
Ser Gly Gly Ser
 1              


<210> 19
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 19
Gly Gly Ser Gly
 1              


<210> 20
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 20
Gly Gly Ser Gly Gly
 1               5  


<210> 21
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 21
Gly Ser Gly Ser Gly
 1               5  


<210> 22
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 22
Gly Ser Gly Gly Gly
 1               5  


<210> 23
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
Gly Gly Gly Ser Gly
 1               5  


<210> 24
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
Gly Ser Ser Ser Gly
 1               5  


<210> 25
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 25
Glu Val Gly Ser Tyr Asp Ala Leu His Tyr Ala Cys Pro Pro Asp Tyr
 1               5                  10                  15      
Tyr Ala Cys Tyr Tyr Ser Gly Arg Ser Ala Gly Gly Gly Gly Thr Glu
            20                  25                  30          
Asn Leu Tyr Phe Gln Gly Ser Gly Gly Ser
        35                  40          


<210> 26
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 26
Glu Val Gly Ser Tyr Asn Ser Tyr His Ala Tyr Cys Pro His Pro Leu
 1               5                  10                  15      
Tyr Pro Cys Thr Ala Ser Gly Arg Ser Ala Gly Gly Gly Gly Thr Glu
            20                  25                  30          
Asn Leu Tyr Phe Gln Gly Ser Gly Gly Ser
        35                  40          


<210> 27
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 27
Glu Val Gly Ser Tyr Ala Ser Ser Ala Val Leu Cys Val Thr Ala Tyr
 1               5                  10                  15      
Phe Ser Cys Asn Ser Ser Gly Arg Ser Ala Gly Gly Gly Gly Thr Glu
            20                  25                  30          
Asn Leu Tyr Phe Gln Gly Ser Gly Gly Ser
        35                  40          


<210> 28
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 28
Glu Val Gly Ser Tyr Asn Phe Val Ala Asp Ser Cys Pro Asp His Pro
 1               5                  10                  15      
Tyr Pro Cys Ser Ala Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 29
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 29
Glu Val Gly Ser Tyr Asn Phe Val Ala Asp Ser Cys Pro Asp His Pro
 1               5                  10                  15      
Tyr Pro Cys Ser Ala Ser Gly Arg Ser Ala Gly Gly Gly Gly Thr Glu
            20                  25                  30          
Asn Leu Tyr Phe Gln Gly Ser Gly Gly Ser
        35                  40          


<210> 30
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 30
Glu Val Gly Ser Tyr Ile Val His His Ser Asp Cys Asp Ala Phe Tyr
 1               5                  10                  15      
Pro Tyr Cys Asp Ser Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 31
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 31
Glu Val Gly Ser Tyr Ile Val His His Ser Asp Cys Asp Ala Phe Tyr
 1               5                  10                  15      
Pro Tyr Cys Asp Ser Ser Gly Arg Ser Ala Gly Gly Gly Gly Thr Glu
            20                  25                  30          
Asn Leu Tyr Phe Gln Gly Ser Gly Gly Ser
        35                  40          


<210> 32
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 32
Glu Val Gly Ser Tyr Tyr Ser Ala Tyr Pro Ala Cys Asp Ser His Tyr
 1               5                  10                  15      
Pro Tyr Cys Asn Ser Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 33
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 33
Glu Val Gly Ser Tyr Tyr Ser Ala Tyr Pro Ala Cys Asp Ser His Tyr
 1               5                  10                  15      
Pro Tyr Cys Asn Ser Ser Gly Arg Ser Ala Gly Gly Gly Gly Thr Glu
            20                  25                  30          
Asn Leu Tyr Phe Gln Gly Ser Gly Gly Ser
        35                  40          


<210> 34
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 34
Glu Val Gly Ser Tyr Pro Asn Pro Ser Ser Asp Cys Val Pro Tyr Tyr
 1               5                  10                  15      
Tyr Ala Cys Ala Tyr Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 35
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 35
Glu Val Gly Ser Tyr Pro Asn Pro Ser Ser Asp Cys Val Pro Tyr Tyr
 1               5                  10                  15      
Tyr Ala Cys Ala Tyr Ser Gly Arg Ser Ala Gly Gly Gly Gly Thr Glu
            20                  25                  30          
Asn Leu Tyr Phe Gln Gly Ser Gly Gly Ser
        35                  40          


<210> 36
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 36
Glu Val Gly Ser Tyr Tyr Ser Ala Tyr Pro Ala Cys Asp Ser His Tyr
 1               5                  10                  15      
Pro Tyr Cys Gln Ser Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 37
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 37
Glu Val Gly Ser Tyr Tyr Ser Ala Tyr Pro Ala Cys Asp Ser His Tyr
 1               5                  10                  15      
Pro Tyr Cys Asn Ser Ala Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 38
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 38
Glu Val Gly Ser Tyr Pro Gln Pro Ser Ser Asp Cys Val Pro Tyr Tyr
 1               5                  10                  15      
Tyr Ala Cys Ala Tyr Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 39
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 39
Glu Val Gly Ser Tyr Pro Asn Pro Ala Ser Asp Cys Val Pro Tyr Tyr
 1               5                  10                  15      
Tyr Ala Cys Ala Tyr Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 40
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 40
Glu Val Gly Ser Tyr Pro Thr Asp Leu Asp Ala Cys Ala Asp Ala Pro
 1               5                  10                  15      
Asn His Cys His Phe Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 41
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 41
Glu Val Gly Ser Tyr Ser Ser Thr His Ala His Cys His His Ser Pro
 1               5                  10                  15      
Ala Asn Cys Ile Ser Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 42
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 42
Glu Val Gly Ser Tyr Asp Thr Asp Tyr Asp Phe Cys Pro Ile Leu Arg
 1               5                  10                  15      
His Arg Cys Asp Ser Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 43
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 43
Glu Val Gly Ser Tyr Asn Asp Tyr Asn Tyr His Cys Lys Trp Arg Pro
 1               5                  10                  15      
Ser Arg Cys His Asn Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 44
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 44
Glu Val Gly Ser Tyr Tyr His Asp Tyr Asp Asp Cys Arg Val Leu Pro
 1               5                  10                  15      
Arg Arg Cys Phe Asn Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 45
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 45
Glu Val Gly Ser Tyr Ser Asn Asn Phe Ala Ser Cys Leu Trp Arg His
 1               5                  10                  15      
Arg Ser Cys Ala Asp Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 46
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 46
Glu Val Gly Ser Tyr Thr Asp Asn Tyr Asp Tyr Cys Pro Arg Leu Arg
 1               5                  10                  15      
Arg Lys Cys Tyr His Ser Gly Arg Ser Ala Gly Gly Gly Gly Ser Pro
            20                  25                  30          
Leu Gly Leu Ala Gly Ser Gly Gly Ser
        35                  40      


<210> 47
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 47
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Ser Ser Gly
            20                  25                  30          
Tyr His Trp Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
        35                  40                  45              
Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser Leu
    50                  55                  60                  
Lys Ser Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Tyr Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 48
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 48
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Arg Gly Arg
            20                  25                  30          
Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ser Ser Trp Pro
                85                  90                  95      
Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105                 


<210> 49
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 49
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Gly
            20                  25                  30          
Gly Val Gly Val Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Leu Ala Leu Ile Asp Trp Ala Asp Asp Lys Tyr Tyr Ser Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Gly Gly Ser Asp Thr Val Ile Gly Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 50
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 50
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr Leu Trp Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105     


<210> 51
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 51
tcgggtgagg ttggatccta c                                           21

<210> 52
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 52
gtacaggttc tcggtaccac c                                           21

<210> 53
<211> 65
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 53
tggagacaca gacaggatca ctggagactg ggtcagcagg atatcggatc ctgaaccgcc 60
tgaac                                                             65

<210> 54
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 54
cttcgctgtt tttcaatatt ttctgttatt gcttcagttt tagcaggatc cgaggttgga 60
tcctac                                                            66

<210> 55
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1, 5
<223> Xaa = Asp, Ala, Tyr, Ser, Thr, Asn, Ile, Leu, Phe, Val, His, and Pro

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Ala, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
Pro, Gln, Arg, Ser, Thr, Val, Trp, and Tyr

<220> 
<221> VARIANT        
<222> 1
<223> Present in repeats of six

<220> 
<221> VARIANT        
<222> 3
<223> Present in repeats of six

<220> 
<221> VARIANT        
<222> 5
<223> Present in repeats of two

<400> 55
Xaa Cys Xaa Cys Xaa
 1               5  


<210> 56
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1, 5
<223> Xaa = Asp, Ala, Tyr, Ser, Thr, Asn, Ile, Leu, Phe, Val, His, and Pro

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Ala, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn,
Pro, Gln, Arg, Ser, Thr, Val, Trp, and Tyr

<220> 
<221> VARIANT        
<222> 1
<223> Present in repeats of six

<220> 
<221> VARIANT        
<222> 3
<223> Present in repeats of eight

<220> 
<221> VARIANT        
<222> 5
<223> Present in repeats of two

<400> 56
Xaa Cys Xaa Cys Xaa
 1               5  


<210> 57
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1, 3, 5
<223> Xaa = Asp, Ala, Tyr, Ser, Thr, Asn, Ile, Leu, Phe, Val,
His, and Pro

<220> 
<221> VARIANT        
<222> 1
<223> Present in repeats of six

<220> 
<221> VARIANT        
<222> 3
<223> Present in repeats of six

<220> 
<221> VARIANT        
<222> 5
<223> Present in repeats of two

<400> 57
Xaa Cys Xaa Cys Xaa
 1               5  


<210> 58
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1, 3, 5
<223> Xaa = Asp, Ala, Tyr, Ser, Thr, Asn, Ile, Leu, Phe, Val,
His, and Pro

<220> 
<221> VARIANT        
<222> 1
<223> Present in repeats of six

<220> 
<221> VARIANT        
<222> 3
<223> Present in repeats of eight

<220> 
<221> VARIANT        
<222> 5
<223> Present in repeats of two

<400> 58
Xaa Cys Xaa Cys Xaa
 1               5  


<210> 59
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 59
Tyr Ser Ile Ser Ser Gly Tyr His Trp Ser Trp Ile
 1               5                  10          


<210> 60
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 60
Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser Leu
 1               5                  10                  15      
Lys Ser Arg Leu
            20  


<210> 61
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 61
Ala Arg Ser Tyr Val Tyr Phe Asp Tyr
 1               5                  


<210> 62
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 62
Arg Ala Ser Gln Ser Val Arg Gly Arg Phe Leu Ala
 1               5                  10          


<210> 63
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 63
Asp Ala Ser Asn Arg Ala Thr Gly Ile
 1               5                  


<210> 64
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 64
Tyr Cys Gln Gln Ser Ser Ser Trp Pro Pro Thr
 1               5                  10      


<210> 65
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 65
Phe Ser Leu Ser Thr Gly Gly Val Gly Val Gly Trp Ile
 1               5                  10              


<210> 66
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 66
Leu Ala Leu Ile Asp Trp Ala Asp Asp Lys Tyr Tyr Ser Pro Ser Leu
 1               5                  10                  15      
Lys Ser Arg Leu
            20  


<210> 67
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 67
Ala Arg Gly Gly Ser Asp Thr Val Ile Gly Asp Trp Phe Ala Tyr
 1               5                  10                  15  


<210> 68
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 68
Arg Ala Ser Gln Ser Ile Gly Ser Tyr Leu Ala
 1               5                  10      


<210> 69
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 69
Asp Ala Ser Asn Leu Glu Thr Gly Val
 1               5                  


<210> 70
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 70
Tyr Cys Gln Gln Gly Tyr Tyr Leu Trp Thr
 1               5                  10  


<210> 71
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1, 3, 5
<223> Xaa = Asp, Ala, Tyr, Ser, Thr, Asn, Ile, Leu, Phe, Val,
His, and Pro

<220> 
<221> VARIANT        
<222> 1
<223> Can be present in repeats of at least three and up to 10

<220> 
<221> VARIANT        
<222> 3
<223> Can be present in repeats of at least three and up to 10

<220> 
<221> VARIANT        
<222> 5
<223> Can be present in repeats of at least one and up to 10

<400> 71
Xaa Cys Xaa Cys Xaa
 1               5 


<210> 72
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 72
Asn Phe Val Ala Asp Ser Cys Pro Asp His Pro Tyr Pro Cys Ser
 1               5                  10                  15      
Ala


<210> 73
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 73
Ile Val His His Ser Asp Cys Asp Ala Phe Tyr Pro Tyr Cys Asp
 1               5                  10                  15      
Ser


<210> 74
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 74
Tyr Ser Ala Tyr Pro Ala Cys Asp Ser His Tyr Pro Tyr Cys Asn
 1               5                  10                  15      
Ser


<210> 75
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 75
Pro Asn Pro Ser Ser Asp Cys Val Pro Tyr Tyr Tyr Ala Cys Ala
 1               5                  10                  15      
Tyr


<210> 76
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 76
Tyr Ser Ala Tyr Pro Ala Cys Asp Ser His Tyr Pro Tyr Cys Gln 
 1               5                  10                  15      
Ser


<210> 77
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 77
Pro Gln Pro Ser Ser Asp Cys Val Pro Tyr Tyr Tyr Ala Cys Ala
 1               5                  10                  15      
Tyr


<210> 78
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 78
Pro Asn Pro Ala Ser Asp Cys Val Pro Tyr Tyr Tyr Ala Cys Ala
 1               5                  10                  15      
Tyr


<210> 79
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 79
Pro Thr Asp Leu Asp Ala Cys Ala Asp Ala Pro Asn His Cys His
 1               5                  10                  15      
Phe


<210> 80
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 80
Ser Ser Thr His Ala His Cys His His Ser Pro Ala Asn Cys Ile
 1               5                  10                  15      
Ser


<210> 81
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 81
Asp Thr Asp Tyr Asp Phe Cys Pro Ile Leu Arg His Arg Cys Asp
 1               5                  10                  15      
Ser


<210> 82
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 82
Asn Asp Tyr Asn Tyr His Cys Lys Trp Arg Pro Ser Arg Cys His
 1               5                  10                  15      
Asn


<210> 83
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 83
Tyr His Asp Tyr Asp Asp Cys Arg Val Leu Pro Arg Arg Cys Phe
 1               5                  10                  15      
Asn


<210> 84
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 84
Asn Asn Phe Ala Ser Cys Leu Trp Arg His Arg Ser Cys Ala Asp
 1               5                  10                  15   


<210> 85
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 85
Thr Asp Asn Tyr Asp Tyr Cys Pro Arg Leu Arg Arg Lys Cys Tyr 
 1               5                  10                  15  
His   


<210> 86
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1, 3, 5
<223> Xaa = Ala, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu,
Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp, or Tyr


<220> 
<221> VARIANT        
<222> 1
<223> Can be present in repeats of at least three and up to 10

<220> 
<221> VARIANT        
<222> 3
<223> Can be present in repeats of at least three and up to 10

<220> 
<221> VARIANT        
<222> 5
<223> Can be present in repeats of at least one and up to 10

<400> 86
Xaa Cys Xaa Cys Xaa
 1               5  


<210> 87
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature   
<222> 1, 2, 7, 8, 13, 14
<223> n = A,T,C or G

<220> 
<221> misc_feature   
<222> 3, 9, 15
<223> n = A,T,C or G

<220> 
<221> misc_feature   
<222> 6, 12
<223> n = T or C

<220> 
<221> misc_feature   
<222> 1, 2, 3
<223> Can be present in repeats of at least three and up to 10

<220> 
<221> misc_feature   
<222> 7, 8, 9
<223> Can be present in repeats of at least three and up to 10

<220> 
<221> misc_feature   
<222> 13, 14, 15
<223> Can be present in repeats of at least one and up to 10

<400> 87
nnntgnnnnt gnnnn                                                  15