                         SEQUENCE LISTING

<110>  Probiodrug AG
 
<120>  Humanized and de-immunized antibodies

<130>  PBD135WO

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant Polypeptide

<400>  1

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Thr Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  2
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant Polypeptide

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Asp Gly Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Thr Thr Val His 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  3
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant peptide

<400>  3

Ser Ser Gln Ser Leu Leu Tyr Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15  


<210>  4
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  4

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  5
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant peptide

<400>  5

Val Gln Gly Thr His Phe Pro 
1               5           


<210>  6
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant peptide

<400>  6

Gly Tyr Ser Phe Thr Gly His Thr Met Asn 
1               5                   10  


<210>  7
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant peptide

<400>  7

Leu Ile Asn Pro Ser Asp Gly Val Thr Arg Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant peptide

<400>  8

Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr 
1               5                   10  


<210>  9
<211>  336
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Recombinant nucleic acid

<400>  9
gacgtggtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca agtcaagtca gagcctcctg cactccgacg gcaagaccta cttgaactgg      120

ttccagcaga ggccaggcca gtctccaagg cgcctgacct atctggtgtc taagctggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgacttcac actgaagatc      240

agcagggtgg aggctgagga tgtcggagtc tactactgcg tgcaaggtac acacttccca      300

ttcacgttcg gcggagggac caaggtggaa atcaaa                                336


<210>  10
<211>  357
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid

<400>  10
caggtgcagc tcgtgcagtc tggggctgag gtggtgaagc caggtgcctc agtgaaggtc       60

tcctgcaagg catctggtta ctcattcact ggtcacacca tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggactc atcaatcctt ccgatggtgt tactaggtac      180

aaccagaagt tccagggcag agtcaccatc accagggaca cgtccacgac caccgttcac      240

atggagctga ccagcctgac atctgaggac acggccacct actactgtac gagagaggcg      300

aaacgggagt gggacgagac ttactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  11
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Recombinant nucleic acid

<400>  11
tcaagtcaga gcctcctgca ctccgacggc aagacctact tgaac                       45


<210>  12
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Recombinant nucleic acid

<400>  12
ctggtgtcta agctggactc t                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Recombinant nucleic acid

<400>  13
gtgcaaggta cacacttccc a                                                 21


<210>  14
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Recombinant nucleic acid

<400>  14
ggttactcat tcactggtca caccatgaac                                        30


<210>  15
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Recombinant nucleic acid

<400>  15
ctcatcaatc cttccgatgg tgttactagg tacaaccaga agttccaggg c                51


<210>  16
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Recombinant nucleic acid

<400>  16
gaggcgaaac gggagtggga cgagacttac                                        30


<210>  17
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant polypeptide

<400>  17

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Thr Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  18
<211>  449
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant polypeptide

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Asp Gly Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Thr Thr Val His 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  19
<211>  449
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant polypeptide

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Asp Gly Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Thr Thr Val His 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  20
<211>  657
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Recombinant nucleic acid

<400>  20
gacgtggtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca agtcaagtca gagcctcctg cactccgacg gcaagaccta cttgaactgg      120

ttccagcaga ggccaggcca gtctccaagg cgcctgacct atctggtgtc taagctggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgacttcac actgaagatc      240

agcagggtgg aggctgagga tgtcggagtc tactactgcg tgcaaggtac acacttccca      300

ttcacgttcg gcggagggac caaggtggaa atcaaaagga ccgtggccgc accctctgtg      360

ttcatcttcc cccccagcga cgagcagctg aagagcggca ctgcatctgt cgtgtgtctg      420

ctgaacaact tctacccaag ggaggcgaaa gtgcagtgga aggtagacaa cgccttgcaa      480

tccggcaact cccaggagag cgtgaccgag caggacagca aagactcaac ctacagcctg      540

agcagtactt tgaccctgtc taaggccgat tacgagaagc acaaggtgta cgcctgcgag      600

gtaacccacc agggactgag ctctcccgtg accaagagct tcaacagggg cgagtgc         657


<210>  21
<211>  1347
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Recombinant nucleic acid

<400>  21
caggtgcagc tcgtgcagtc tggggctgag gtggtgaagc caggtgcctc agtgaaggtc       60

tcctgcaagg catctggtta ctcattcact ggtcacacca tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggactc atcaatcctt ccgatggtgt tactaggtac      180

aaccagaagt tccagggcag agtcaccatc accagggaca cgtccacgac caccgttcac      240

atggagctga ccagcctgac atctgaggac acggccacct actactgtac gagagaggcg      300

aaacgggagt gggacgagac ttactggggc cagggaaccc tggtcaccgt ctcctcagcc      360

agcactaagg gcccgagcgt gttccccctc gcccctagca gtaagagcac cagcggtggc      420

acggcggcac ttggctgctt ggttaaggac tacttcccag agcccgtgac cgtgtcctgg      480

aactctgggg cacttaccag tggcgtgcac accttccccg ctgtactgca gagcagcggc      540

ttgtacagct tgtcttccgt cgtaacggtg cccagcagca gcttgggaac ccagacctac      600

atctgcaacg taaaccacaa gccatccaac accaaggtag acaaaaaggt cgaacccaag      660

tcctgcgaca agacccacac ctgtccaccc tgtcctgcac ccgagctcct gggaggtccc      720

agcgttttcc tgttccctcc aaagccaaag gataccctga tgatcagcag gacccccgag      780

gtgacctgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gttgatgggg tggaggtaca caatgccaag accaaacctc gagaggagca atacaacagc      900

acctaccgag ttgtgagcgt gcttaccgtg ctgcaccagg actggctgaa cggcaaggag      960

tacaagtgcg ctgtgagcaa caaggctctg ccggctccca tcgagaagac catcagcaag     1020

gccaagggcc agcccaggga gccacaggtt tacacgttgc ccccctcaag ggacgagttg     1080

accaagaacc aggtttccct cacgtgcctt gtgaagggct tctaccccag cgacatcgcc     1140

gtggaatggg agagcaacgg gcagcccgag aacaactaca agacgacccc ccctgttctg     1200

gacagcgacg gctctttctt cctgtattca aagctcaccg tggacaaaag caggtggcag     1260

cagggtaatg tgttctcctg cagcgtgatg cacgaggccc tgcataacca ctacacccaa     1320

aagagcttga gcctctcccc cggtaag                                         1347


<210>  22
<211>  1347
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Recombinant nucleic acid

<400>  22
caggtgcagc tcgtgcagtc tggggctgag gtggtgaagc caggtgcctc agtgaaggtc       60

tcctgcaagg catctggtta ctcattcact ggtcacacca tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggactc atcaatcctt ccgatggtgt tactaggtac      180

aaccagaagt tccagggcag agtcaccatc accagggaca cgtccacgac caccgttcac      240

atggagctga ccagcctgac atctgaggac acggccacct actactgtac gagagaggcg      300

aaacgggagt gggacgagac ttactggggc cagggaaccc tggtcaccgt ctcctcagcc      360

agcactaagg gcccgagcgt gttccccctc gcccctagca gtaagagcac cagcggtggc      420

acggcggcac ttggctgctt ggttaaggac tacttcccag agcccgtgac cgtgtcctgg      480

aactctgggg cacttaccag tggcgtgcac accttccccg ctgtactgca gagcagcggc      540

ttgtacagct tgtcttccgt cgtaacggtg cccagcagca gcttgggaac ccagacctac      600

atctgcaacg taaaccacaa gccatccaac accaaggtag acaaaaaggt cgaacccaag      660

tcctgcgaca agacccacac ctgtccaccc tgtcctgcac ccgagctcct gggaggtccc      720

agcgttttcc tgttccctcc aaagccaaag gataccctga tgatcagcag gacccccgag      780

gtgacctgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gttgatgggg tggaggtaca caatgccaag accaaacctc gagaggagca atacaacagc      900

acctaccgag ttgtgagcgt gcttaccgtg ctgcaccagg actggctgaa cggcaaggag      960

tacaagtgca aggtgagcaa caaggctctg ccggctccca tcgagaagac catcagcaag     1020

gccaagggcc agcccaggga gccacaggtt tacacgttgc ccccctcaag ggacgagttg     1080

accaagaacc aggtttccct cacgtgcctt gtgaagggct tctaccccag cgacatcgcc     1140

gtggaatggg agagcaacgg gcagcccgag aacaactaca agacgacccc ccctgttctg     1200

gacagcgacg gctctttctt cctgtattca aagctcaccg tggacaaaag caggtggcag     1260

cagggtaatg tgttctcctg cagcgtgatg cacgaggccc tgcataacca ctacacccaa     1320

aagagcttga gcctctcccc cggtaag                                         1347


<210>  23
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  23

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
1               5                   10                  15      


<210>  24
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  24

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
1               5                   10                  15  


<210>  25
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  25

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  


<210>  26
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  26

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln 
1               5                   10              


<210>  27
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  27

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His 
1               5                   10          


<210>  28
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  28

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His 
1               5                   10      


<210>  29
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  29

Glu Phe Arg His Asp Ser Gly Tyr Glu Val 
1               5                   10  


<210>  30
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  30

Glu Phe Arg His Asp Ser Gly Tyr Glu 
1               5                   


<210>  31
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  31

Glu Phe Arg His Asp Ser Gly Tyr 
1               5               


<210>  32
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  32

Glu Phe Arg His Asp Ser Gly 
1               5           


<210>  33
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  33

Glu Phe Arg His Asp Ser 
1               5       


<210>  34
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  34

Glu Phe Arg His Asp 
1               5   


<210>  35
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  35

Glu Phe Arg His 
1               


<210>  36
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  PYRROLIDONE CARBOXYLIC ACID

<400>  36

Glu Phe Arg 
1           


<210>  37
<211>  42
<212>  PRT
<213>  Human

<400>  37

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  38
<211>  40
<212>  PRT
<213>  Human

<400>  38

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val 
        35                  40  


<210>  39
<211>  38
<212>  PRT
<213>  Human

<400>  39

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly 
        35              


<210>  40
<211>  40
<212>  PRT
<213>  Human

<400>  40

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
1               5                   10                  15      


Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 
            20                  25                  30          


Met Val Gly Gly Val Val Ile Ala 
        35                  40  


<210>  41
<211>  38
<212>  PRT
<213>  Human

<400>  41

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
1               5                   10                  15      


Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 
            20                  25                  30          


Met Val Gly Gly Val Val 
        35              


<210>  42
<211>  36
<212>  PRT
<213>  Human

<400>  42

Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
1               5                   10                  15      


Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 
            20                  25                  30          


Met Val Gly Gly 
        35      


<210>  43
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  43
actgtggctg caccatctgt cttc                                              24


<210>  44
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  44
ctaacactct cccctgttga agctc                                             25


<210>  45
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  45
agggaaccct ggtcaccgtc tcc                                               23


<210>  46
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  46
tcatttaccc ggagacaggg agagg                                             25


<210>  47
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  47
caagtcagag cctcttatat agtg                                              24


<210>  48
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  48
gtaccttgca cgcagtaata aac                                               23


<210>  49
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant polypeptide

<400>  49

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Ser Asn Gly Val Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Thr Thr Thr Val His 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Ala Lys Arg Glu Trp Asp Glu Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


