﻿               SEQUENCE LISTING

<110> SANOFI

<120> MODIFIED LIPIDATED RELAXIN B CHAIN PEPTIDES AND THEIR THERAPEUTIC USE

<130> PR82713/KLP/MGG/gg

<150> EP18305094
<151> 2018-01-31

<160> 104

<170> BiSSAP 1.3.6

<210> 1
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 1
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 2
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 2
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 3
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 3
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 4
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)2-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)2-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 4
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 5
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)4-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 5
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 6
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)2-(gamma glutamic
      acid)3-Stearoyl group (-(TTDS)2-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 6
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 7
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Stearoyl group (-(TTDS)3-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 7
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 8
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)4-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 8
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 9
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)2-(gamma glutamic
      acid)2-Palmitoyl group (-(TTDS)2-(gE)2-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 9
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 10
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)2-(gamma glutamic
      acid)4-Palmitoyl group (-(TTDS)2-(gE)4-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 10
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 11
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 11
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Ala Xaa 
            20                  

<210> 12
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents Citruline (Cit)

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 12
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 13
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 13
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Lys Arg Ala Xaa 
            20                  

<210> 14
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 20
<223> Xaa in position 20 represents D-serine (Dser)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 14
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Xaa Lys Arg Ala Xaa 
            20                  

<210> 15
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 20
<223> Xaa in position 20 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 15
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Xaa Lys Arg Ala Xaa 
            20                  

<210> 16
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)2-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)2-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents D-lysine (Dlys)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 16
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 17
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)2-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)2-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents D-lysine (Dlys)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 17
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Ala Xaa 
            20                  

<210> 18
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)2-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)2-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents D-lysine (Dlys)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 18
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 19
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 reprsents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 19
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 20
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Stearoyl group (-(TTDS)3-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 20
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 21
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)4-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 21
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 22
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2DGA)3-(gamma
      glutamic acid)3-Palmitoyl group (-(PEG2DGA)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 22
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 23
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 23
Leu Glu Gly Arg Glu Leu Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 24
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 24
Leu Glu Gly Arg Glu Phe Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 25
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 25
Leu Glu Gly Arg Glu Gln Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 26
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)3-Stearoyl group (-(PEG2)4-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 26
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 27
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 27
Leu Glu Gly Arg Glu Arg Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 28
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 6
<223> Xaa in position 6 represents homolysine (Hly)

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 28
Leu Glu Gly Arg Glu Xaa Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 29
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 9
<223> Xaa in position 9 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 29
Leu Glu Gly Arg Glu Lys Val Arg Xaa Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 30
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Stearoyl group (-(TTDS)3-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 30
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Ala Xaa 
            20                  

<210> 31
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 31
Leu Glu Gly Arg Glu Arg Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Arg Xaa 
            20                  

<210> 32
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2DGA)3-(gamma
      glutamic acid)3-Stearoyl group (-(PEG2DGA)3-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 32
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 33
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)2-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)2-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 33
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 34
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)2-(gamma glutamic
      acid)3-Stearoyl group (-(TTDS)2-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 34
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 35
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 20
<223> Xaa in position 20 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 35
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Xaa Lys Arg Ala Xaa 
            20                  

<210> 36
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents D-lysine (Dlys)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 36
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 37
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 37
Leu Glu Gly Arg Glu Leu Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Arg Xaa 
            20                  

<210> 38
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)3-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 38
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 39
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 39
Leu Glu Gly Arg Glu Phe Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Arg Xaa 
            20                  

<210> 40
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 40
Leu Glu Gly Arg Glu Gln Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Arg Xaa 
            20                  

<210> 41
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2DGA)3-(gamma
      glutamic acid)3-Palmitoyl group (-(PEG2DGA)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 41
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Ala Xaa 
            20                  

<210> 42
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)4-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)4-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 42
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Ala Xaa 
            20                  

<210> 43
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 6
<223> Xaa in position 6 represents homolysine (Hly)

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Stearoyl group (-(TTDS)3-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 43
Leu Glu Gly Arg Glu Xaa Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Ala Xaa 
            20                  

<210> 44
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 20
<223> Xaa in position 20 represents D-serine (Dser)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 44
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Xaa Lys Arg Ala Xaa 
            20                  

<210> 45
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)5-(gamma glutamic
      acid)3-Palmitoyl group (-(PEG2)5-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 45
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 46
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2)5-(gamma glutamic
      acid)4-Palmitoyl group (-(PEG2)5-(gE)4-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 46
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 47
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 47
Leu Glu Gly Arg Glu Lys Val Arg Ala Lys Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 48
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 48
Leu Glu Gly Arg Glu Lys Val Arg Ala Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 49
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl group (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-Methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 49
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Lys 
            20                  

<210> 50
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2DGA)3-(gamma
      glutamic acid)3-Stearoyl group (-(PEG2DGA)3-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 50
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 51
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)4-Stearoyl group (-(TTDS)3-(gE)4-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 51
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 52
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)2-Stearoyl group (-(TTDS)3-(gE)2-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 52
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 53
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(PEG2DGA)3-(gamma
      glutamic acid)4-Stearoyl group (-(PEG2DGA)3-(gE)4-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 53
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 54
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)2-(gamma glutamic
      acid)4-Stearoyl group (-(TTDS)2-(gE)4-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 54
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 55
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 55
Leu Glu Gly Arg Glu Arg Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Arg Xaa 
            20                  

<210> 56
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents citruline (Cit)

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Stearoyl (-(TTDS)3-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 56
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 57
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents homolysine (Hly)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 57
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Ala Xaa 
            20                  

<210> 58
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)4-(gamma glutamic
      acid)3-Stearoyl (-(TTDS)4-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 58
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Ala Xaa 
            20                  

<210> 59
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)4-(gamma glutamic
      acid)3-Stearoyl (-(TTDS)4-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 59
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Lys Xaa 
            20                  

<210> 60
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)2-(gamma glutamic
      acid)3-Stearoyl (-(TTDS)2-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 60
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Lys Xaa 
            20                  

<210> 61
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Stearoyl (-(TTDS)3-(gE)3-Stea)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 61
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Lys Xaa 
            20                  

<210> 62
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)4-Palmitoyl (-(TTDS)3-(gE)4-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 62
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 63
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 63
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Gln Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 64
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 64
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Arg Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 65
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 9
<223> Xaa in position 9 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 65
Leu Glu Gly Arg Glu Lys Val Arg Xaa Gln Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 66
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 20
<223> Xaa in position 20 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 66
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Xaa Xaa Arg Ala Xaa 
            20                  

<210> 67
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 67
Leu Glu Gly Arg Glu Arg Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 68
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 23
<223> Xaa in position 23 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 68
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Xaa Lys 
            20                  

<210> 69
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 23
<223> Xaa in position 23 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 69
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Xaa Arg 
            20                  

<210> 70
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 70
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Ile Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 71
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 71
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Ala Lys 
            20                  

<210> 72
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 20
<223> Xaa in position 20 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 72
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Xaa Arg Arg Ala Xaa 
            20                  

<210> 73
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 73
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Lys Trp Ser Xaa Arg Ala Lys 
            20                  

<210> 74
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)4-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)4-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 74
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Ile Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 75
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)4-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)4-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 75
Leu Glu Gly Arg Glu Arg Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Arg Xaa 
            20                  

<210> 76
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 76
Leu Glu Gly Arg Glu Arg Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Arg Xaa 
            20                  

<210> 77
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)4-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)4-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 77
Leu Glu Gly Arg Glu Arg Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Arg Xaa 
            20                  

<210> 78
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)4-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)4-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 78
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 79
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 79
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Lys Phe Ser Xaa Arg Lys Xaa 
            20                  

<210> 80
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents 5-chloro-tryptophan (Trp(5Cl))

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 80
Leu Glu Gly Arg Glu Arg Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Arg Xaa 
            20                  

<210> 81
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 1
<223> Xaa in position 1 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 81
Xaa Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 82
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 9
<223> Xaa in position 9 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 82
Leu Glu Gly Arg Glu Lys Val Arg Xaa Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Ala Xaa 
            20                  

<210> 83
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 83
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Lys Trp Ser Xaa Arg Lys Xaa 
            20                  

<210> 84
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 84
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Ile Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 85
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 9
<223> Xaa in position 9 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 85
Leu Glu Gly Arg Glu Arg Val Arg Xaa Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Trp Ser Xaa Arg Arg Xaa 
            20                  

<210> 86
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 1
<223> Xaa in position 1 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 86
Xaa Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Ile Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 87
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 87
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Arg Arg Ala Xaa 
            20                  

<210> 88
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents homolysine (Hly)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 88
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 89
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents α-methyl-phenylalanine (Mph)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 89
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Arg Arg Ala Xaa 
            20                  

<210> 90
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 90
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Ala Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 91
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents 4-fluoro-phenylalanine (Pfp)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 91
Leu Glu Gly Arg Glu Arg Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Arg Xaa 
            20                  

<210> 92
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 represents 5-fluoro-tryptophan (Trp(5F))

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 92
Leu Glu Gly Arg Glu Arg Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Xaa Ser Xaa Arg Arg Xaa 
            20                  

<210> 93
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 93
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Thr Arg Arg Ala Xaa 
            20                  

<210> 94
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Palmitoyl (-(TTDS)3-(gE)3-Palm)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 94
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Val Arg Arg Ala Xaa 
            20                  

<210> 95
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Myristoyl (-(TTDS)3-(gE)3-Myr)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<220> 
<221> VARIANT
<222> 24
<223> Xaa in position 24 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<400> 95
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Xaa 
            20                  

<210> 96
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)3-Myristoyl (-(TTDS)3-(gE)3-Myr)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 96
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Lys 
            20                  

<210> 97
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 10
<223> Xaa in position 10 represents 2-amino-4-acetamido-hexanoic acid
      (Nε-Acetyl-lysine - K(Ac))

<220> 
<221> VARIANT
<222> 12
<223> Xaa in position 12 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 13
<223> Xaa in position 13 represents 2-amino-isobutyric acid (Aib)

<220> 
<221> VARIANT
<222> 16
<223> Xaa in position 16 represents a lysine amino acid bound on the
      nitrogen atom of its lateral chain to a -(TTDS)3-(gamma glutamic
      acid)4-Myristoyl (-(TTDS)3-(gE)4-Myr)

<220> 
<221> VARIANT
<222> 21
<223> Xaa in position 21 represents α-methyl-lysine (Mly)

<220> 
<221> VARIANT
<222> 24
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 97
Leu Glu Gly Arg Glu Lys Val Arg Ala Xaa Ile Xaa Xaa Glu Gly Xaa 
1               5                   10                  15      
Ser Thr Phe Ser Xaa Arg Ala Lys 
            20                  

<210> 98
<400> 98
000

<210> 99
<400> 99
000

<210> 100
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> H2-relaxin A chain

<220> 
<223> H2-relaxin A chain

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with a hydrogen atom (H) on its
      N-terminal extremity

<400> 100
Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly Cys Thr 
1               5                   10                  15      
Lys Arg Ser Leu Ala Arg Phe Cys 
            20                  

<210> 101
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> H2-relaxin B chain

<220> 
<223> H2-relaxin B chain

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with a hydrogen atom (H) on its
      N-terminal extremity

<400> 101
Asp Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val 
1               5                   10                  15      
Arg Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
            20                  25                  

<210> 102
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2 - comparison example

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2 - comparison example

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with a hydrogen atom (H) on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 102
Val Ile Lys Leu Ser Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile 
1               5                   10                  15      
Ser Gly Met Ser Thr Trp Ser Lys Arg Ser Leu 
            20                  25          

<210> 103
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2 - comparison example

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2 - comparison example

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 103
Val Ile Lys Leu Ser Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile 
1               5                   10                  15      
Ser Gly Met Ser Thr Trp Ser Lys Arg Ser Leu 
            20                  25          

<210> 104
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide analogue of the B-chain of Relaxin-2 - comparison example

<220> 
<223> Peptide analogue of the B-chain of Relaxin-2 - comparison example

<220> 
<221> VARIANT
<222> 1
<223> The peptide is substituted with an acetyl (Ac) group on its
      N-terminal extremity

<220> 
<221> VARIANT
<222> 27
<223> The peptide is substituted with an –NH2 group on its C-terminal
      extremity

<400> 104
Val Ile Lys Leu Ser Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile 
1               5                   10                  15      
Ser Gly Met Ser Thr Trp Ser Lys Lys Lys Lys 
            20                  25          

