                         SEQUENCE LISTING

<110>  Flagship Pioneering Innovations V, Inc.
 
<120>  METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY OR AUTOIMMUNE 
       DISEASES OR CONDITIONS USING CALCITONIN RECEPTOR ACTIVATORS

<130>  51247-020WO3

<150>  US 62/623,885
<151>  2018-01-30

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  1

Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr Thr Gln Asp Phe 
1               5                   10                  15      


Asn Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly Val Gly Ala Pro 
            20                  25                  30          


<210>  2
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  3
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Ile Leu Lys Leu Gln Val Phe Leu Ile Val Leu Ser Val Ala 
1               5                   10                  15      


Leu Asn His Leu Lys Ala Thr Pro Ile Glu Ser His Gln Val Glu Lys 
            20                  25                  30          


Arg Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe 
        35                  40                  45              


Leu Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn 
    50                  55                  60                  


Val Gly Ser Asn Thr Tyr Gly Lys Arg Asn Ala Val Glu Val Leu Lys 
65                  70                  75                  80  


Arg Glu Pro Leu Asn Tyr Leu Pro Leu 
                85                  


<210>  4
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu 
1               5                   10                  15      


Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Pro Glu Ser 
            20                  25                  30          


Pro 
    


<210>  5
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys His Thr Asp Val Gly Ala Asn Ala 
            20                  25                  30          


Pro 
    


<210>  6
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys His Ser Ser Thr Asp Val Gly Ala 
            20                  25                  30          


Asn Ala Pro 
        35  


<210>  7
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys His Ser Ser Asn Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  8
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          


Gly Ala Asn Ala Pro 
        35          


<210>  9
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Gly Ala Ile Leu Ser Pro Lys Thr Asp Val 
            20                  25                  30          


Gly Ala Asn Ala Pro 
        35          


<210>  10
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Pro Lys Thr Asp Val 
            20                  25                  30          


Gly Ala Asn Ala Pro 
        35          


<210>  11
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Gly Ala Ile Leu Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  12
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Ile Leu Ser Ser Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  13
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Phe Gly Ala Ile Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  14
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Leu Ser Ser Thr Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  15
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Gly Leu Ile Thr Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  16
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Val Leu Ile Gly Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  17
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Asn Asn Phe Gly Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  18
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Ser Ser Asn Asn Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  19
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Val His Ser Ser Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  20
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Leu Val His Ser Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  21
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Ser Asn Asn Phe Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  22
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Lys Gly Gly Gln Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  23
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Arg Thr Thr Gln Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  24
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys His Thr Thr Asn Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  25
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys His Gly Gly Gln Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  26
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys His Lys Lys Asn Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  27
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys His Lys Lys His Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  28
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Ala Thr Asp Val Gly Ala Asn Ala 
            20                  25                  30          


Pro 
    


<210>  29
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Ala Ile Thr Asp Val Gly Ala Asn 
            20                  25                  30          


Ala Pro 
        


<210>  30
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys His Ser Thr Asp Val Gly Ala Asn 
            20                  25                  30          


Ala Pro 
        


<210>  31
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Ala Ile Leu Thr Asp Val Gly Ala 
            20                  25                  30          


Asn Ala Pro 
        35  


<210>  32
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Ala Ile Leu Ser Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  33
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Thr Asp Val Gly Ala Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  34
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  35
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


Val Arg Ser Ser Asn Asn Leu Gly Pro Val Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  36
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Arg Leu Gln Thr Tyr Pro Lys Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  37
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asp Val 
            20                  25                  30          


Gly Ala Asn Ala Pro 
        35          


<210>  38
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Cys Ser Asn Leu Ser Thr Cys Met Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asp Val 
            20                  25                  30          


Gly Ala Asn Ala Pro 
        35          


<210>  39
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Ser Ser Asn Asn Phe Gly Ala Ile Leu Pro Ser Thr Asn Val 
            20                  25                  30          


Gly Ala Asn Ala Pro 
        35          


<210>  40
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Cys Ser Asn Leu Ser Thr Cys Met Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Arg Leu Gln Thr Tyr Pro Lys Thr Asp Val 
            20                  25                  30          


Gly Ala Asn Ala Pro 
        35          


<210>  41
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asp Val 
            20                  25                  30          


Gly Ala Asn Ala Pro 
        35          


<210>  42
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Cys Ser Asn Leu Ser Thr Cys Met Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Pro Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  43
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Ile Leu Ile Leu Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  44
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Glu Ser Ser Glu Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


<210>  45
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45

Cys Ser Asn Leu Ser Thr Cys Met Leu Gly Arg Leu Ser Gln Asp Leu 
1               5                   10                  15      


His Arg Leu Gln Thr Tyr Pro Lys Glu Glu Glu Glu Thr Asp Val Gly 
            20                  25                  30          


Ala Asn Ala Pro 
        35      


