                         SEQUENCE LISTING

<110>  HOMOLOGY MEDICINES, INC.
 
<120>  ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR RESTORING PAH GENE 
       FUNCTION AND METHODS OF USE THEREOF

<130>  610062: HMT-024PC

<150>  62/625,149
<151>  2018-02-01

<150>  62/672,377
<151>  2018-05-16

<160>  153   

<170>  PatentIn version 3.5

<210>  1
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  adeno-associated AAV9

<400>  1

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  2
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  2

Met Thr Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Gln Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  3
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  3

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Gly Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Gly Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  4
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  4

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Ile Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Tyr Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  5
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  5

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Asp 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  6
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  6

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Leu Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Ser Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  7
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  7

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Arg Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  8
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  8

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Val Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  9
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  9

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Arg Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  10
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  10

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Cys Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  11
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  11

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Arg Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Lys Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  12
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  12

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro His Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Asn 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Arg Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Met Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  13
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  13

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Arg Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  14
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  splice acceptor

<400>  14
ctgacctctt ctcttcctcc cacagg                                            26


<210>  15
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  15

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Arg Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Arg Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  16
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  16

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ala Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Arg Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  17
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  novel AAV isolate

<400>  17

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Ile Ala Trp Pro Arg Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Cys Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  18
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 5' ITR

<400>  18
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcct                                            145


<210>  19
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 3' ITR

<400>  19
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  20
<211>  167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV5 5' ITR

<400>  20
ctctcccccc tgtcgcgttc gctcgctcgc tggctcgttt gggggggtgg cagctcaaag       60

agctgccaga cgacggccct ctggccgtcg cccccccaaa cgagccagcg agcgagcgaa      120

cgcgacaggg gggagagtgc cacactctca agcaaggggg ttttgta                    167


<210>  21
<211>  167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV5 3' ITR

<400>  21
tacaaaacct ccttgcttga gagtgtggca ctctcccccc tgtcgcgttc gctcgctcgc       60

tggctcgttt gggggggtgg cagctcaaag agctgccaga cgacggccct ctggccgtcg      120

cccccccaaa cgagccagcg agcgagcgaa cgcgacaggg gggagag                    167


<210>  22
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV2 Rep

<400>  22

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  23
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ser Thr Ala Val Leu Glu Asn Pro Gly Leu Gly Arg Lys Leu Ser 
1               5                   10                  15      


Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Asp Asn Cys Asn Gln Asn 
            20                  25                  30          


Gly Ala Ile Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu 
        35                  40                  45              


Ala Lys Val Leu Arg Leu Phe Glu Glu Asn Asp Val Asn Leu Thr His 
    50                  55                  60                  


Ile Glu Ser Arg Pro Ser Arg Leu Lys Lys Asp Glu Tyr Glu Phe Phe 
65                  70                  75                  80  


Thr His Leu Asp Lys Arg Ser Leu Pro Ala Leu Thr Asn Ile Ile Lys 
                85                  90                  95      


Ile Leu Arg His Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp 
            100                 105                 110         


Lys Lys Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu 
        115                 120                 125             


Asp Arg Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala 
    130                 135                 140                 


Asp His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln 
145                 150                 155                 160 


Phe Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg 
                165                 170                 175     


Val Glu Tyr Met Glu Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys 
            180                 185                 190         


Thr Leu Lys Ser Leu Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His 
        195                 200                 205             


Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile 
    210                 215                 220                 


Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe 
225                 230                 235                 240 


Arg Leu Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly 
                245                 250                 255     


Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly 
            260                 265                 270         


Ser Lys Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu 
        275                 280                 285             


Gly His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln 
    290                 295                 300                 


Glu Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys 
305                 310                 315                 320 


Leu Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln 
                325                 330                 335     


Gly Asp Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly 
            340                 345                 350         


Glu Leu Gln Tyr Cys Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu 
        355                 360                 365             


Leu Glu Lys Thr Ala Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro 
    370                 375                 380                 


Leu Tyr Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg 
385                 390                 395                 400 


Asn Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro 
                405                 410                 415     


Tyr Thr Gln Arg Ile Glu Val Leu Asp Asn Thr Gln Gln Leu Lys Ile 
            420                 425                 430         


Leu Ala Asp Ser Ile Asn Ser Glu Ile Gly Ile Leu Cys Ser Ala Leu 
        435                 440                 445             


Gln Lys Ile Lys 
    450         


<210>  24
<211>  1359
<212>  DNA
<213>  Homo sapiens

<400>  24
atgtccactg cggtcctgga aaacccaggc ttgggcagga aactctctga ctttggacag       60

gaaacaagct atattgaaga caactgcaat caaaatggtg ccatatcact gatcttctca      120

ctcaaagaag aagttggtgc attggccaaa gtattgcgct tatttgagga gaatgatgta      180

aacctgaccc acattgaatc tagaccttct cgtttaaaga aagatgagta tgaatttttc      240

acccatttgg ataaacgtag cctgcctgct ctgacaaaca tcatcaagat cttgaggcat      300

gacattggtg ccactgtcca tgagctttca cgagataaga agaaagacac agtgccctgg      360

ttcccaagaa ccattcaaga gctggacaga tttgccaatc agattctcag ctatggagcg      420

gaactggatg ctgaccaccc tggttttaaa gatcctgtgt accgtgcaag acggaagcag      480

tttgctgaca ttgcctacaa ctaccgccat gggcagccca tccctcgagt ggaatacatg      540

gaggaagaaa agaaaacatg gggcacagtg ttcaagactc tgaagtcctt gtataaaacc      600

catgcttgct atgagtacaa tcacattttt ccacttcttg aaaagtactg tggcttccat      660

gaagataaca ttccccagct ggaagacgtt tctcaattcc tgcagacttg cactggtttc      720

cgcctccgac ctgtggctgg cctgctttcc tctcgggatt tcttgggtgg cctggccttc      780

cgagtcttcc actgcacaca gtacatcaga catggatcca agcccatgta tacccccgaa      840

cctgacatct gccatgagct gttgggacat gtgcccttgt tttcagatcg cagctttgcc      900

cagttttccc aggaaattgg ccttgcctct ctgggtgcac ctgatgaata cattgaaaag      960

ctcgccacaa tttactggtt tactgtggag tttgggctct gcaaacaagg agactccata     1020

aaggcatatg gtgctgggct cctgtcatcc tttggtgaat tacagtactg cttatcagag     1080

aagccaaagc ttctccccct ggagctggag aagacagcca tccaaaatta cactgtcacg     1140

gagttccagc ccctgtatta cgtggcagag agttttaatg atgccaagga gaaagtaagg     1200

aactttgctg ccacaatacc tcggcccttc tcagttcgct acgacccata cacccaaagg     1260

attgaggtct tggacaatac ccagcagctt aagattttgg ctgattccat taacagtgaa     1320

attggaatcc tttgcagtgc cctccagaaa ataaagtaa                            1359


<210>  25
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Silently altered PAH coding sequence

<400>  25
atgtccaccg ctgtgctgga gaaccctggg ctggggagga aactgtcaga cttcgggcag       60

gagacttcat acattgagga taactgtaac cagaatggcg ccatctctct gatcttcagc      120

ctgaaggagg aagtgggcgc cctggcaaag gtgctgcgcc tgtttgagga gaacgacgtg      180

aatctgaccc acatcgagtc ccggccttct agactgaaga aggacgagta cgagttcttt      240

acccacctgg ataagcggtc cctgccagcc ctgacaaaca tcatcaagat cctgaggcac      300

gacatcggag caaccgtgca cgagctgtct cgggacaaga agaaggatac cgtgccctgg      360

ttccctcgga caatccagga gctggataga tttgccaacc agatcctgtc ttacggagca      420

gagctggacg cagatcaccc tggcttcaag gacccagtgt atcgggcccg gagaaagcag      480

tttgccgata tcgcctacaa ttataggcac ggacagccaa tccctcgcgt ggagtatatg      540

gaggaggaga agaagacctg gggcacagtg ttcaagaccc tgaagagcct gtacaagaca      600

cacgcctgct acgagtataa ccacatcttc cccctgctgg agaagtattg tggctttcac      660

gaggacaata tccctcagct ggaggacgtg agccagttcc tgcagacctg cacaggcttt      720

aggctgaggc cagtggcagg actgctgagc tcccgggact tcctgggagg actggccttc      780

agagtgtttc actgcaccca gtacatcagg cacggctcca agccaatgta tacaccagag      840

cccgacatct gtcacgagct gctgggccac gtgcccctgt ttagcgatag atccttcgcc      900

cagttttccc aggagatcgg actggcatct ctgggagcac ctgacgagta catcgagaag      960

ctggccacca tctattggtt cacagtggag tttggcctgt gcaagcaggg cgatagcatc     1020

aaggcctacg gagcaggact gctgtctagc ttcggcgagc tgcagtattg tctgtccgag     1080

aagccaaagc tgctgcccct ggagctggag aagaccgcca tccagaacta caccgtgaca     1140

gagttccagc ccctgtacta tgtggccgag tcttttaacg atgccaagga gaaggtgaga     1200

aatttcgccg ccacaatccc taggcccttc agcgtgcggt acgaccctta tacccagagg     1260

atcgaggtgc tggataatac acagcagctg aagatcctgg ctgactcaat caatagcgaa     1320

atcggaatcc tgtgctccgc cctgcagaaa atcaaatga                            1359


<210>  26
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated AAV2 5'ITR

<400>  26
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtgg                     106


<210>  27
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified AAV2 3'ITR

<400>  27
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gcc                                              143


<210>  28
<211>  130
<212>  DNA
<213>  Homo sapiens

<400>  28
gttggtatca aggttacaag acaggtttaa ggagaccaat agaaactggg catgtggaga       60

cagagaagac tcttgggttt ctgataggca ctgactctct ctgcctattg gtctattttc      120

ccacccttag                                                             130


<210>  29
<211>  116
<212>  DNA
<213>  Mus musculus

<400>  29
gttggtatcc aggttacaag gcagctcaca agaagaagtt gggtgcttgg agacagaggt       60

ctgctttcca gcagacacta actttcagtg tcccctgtct atgtttccct ttttag          116


<210>  30
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Minute virus in mice

<400>  30
aagaggtaag ggtttaaggg atggttggtt ggtggggtat taatgtttaa ttacctggag       60

cacctgcctg aaatcacttt ttttcaggtt gg                                     92


<210>  31
<211>  198
<212>  DNA
<213>  Simian virus 40

<400>  31
gatccagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga       60

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc      120

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag      180

gtgtgggagg ttttttaa                                                    198


<210>  32
<211>  122
<212>  DNA
<213>  Simian virus 40

<400>  32
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

ta                                                                     122


<210>  33
<211>  133
<212>  DNA
<213>  Simian virus 40

<400>  33
tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat       60

aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg      120

gaggtttttt aaa                                                         133


<210>  34
<211>  135
<212>  DNA
<213>  Simian virus 40

<400>  34
gatccagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga       60

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc      120

tgcaataaac aagtt                                                       135


<210>  35
<211>  1654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pHMIA-hPAH-hI1C-032.1 editing element

<400>  35
ctgacctctt ctcttcctcc cacagggcag cggagctact aacttcagcc tgctgaagca       60

ggctggagac gtggaggaga accctggacc tatgtccacc gctgtgctgg agaaccctgg      120

gctggggagg aaactgtcag acttcgggca ggagacttca tacattgagg ataactgtaa      180

ccagaatggc gccatctctc tgatcttcag cctgaaggag gaagtgggcg ccctggcaaa      240

ggtgctgcgc ctgtttgagg agaacgacgt gaatctgacc cacatcgagt cccggccttc      300

tagactgaag aaggacgagt acgagttctt tacccacctg gataagcggt ccctgccagc      360

cctgacaaac atcatcaaga tcctgaggca cgacatcgga gcaaccgtgc acgagctgtc      420

tcgggacaag aagaaggata ccgtgccctg gttccctcgg acaatccagg agctggatag      480

atttgccaac cagatcctgt cttacggagc agagctggac gcagatcacc ctggcttcaa      540

ggacccagtg tatcgggccc ggagaaagca gtttgccgat atcgcctaca attataggca      600

cggacagcca atccctcgcg tggagtatat ggaggaggag aagaagacct ggggcacagt      660

gttcaagacc ctgaagagcc tgtacaagac acacgcctgc tacgagtata accacatctt      720

ccccctgctg gagaagtatt gtggctttca cgaggacaat atccctcagc tggaggacgt      780

gagccagttc ctgcagacct gcacaggctt taggctgagg ccagtggcag gactgctgag      840

ctcccgggac ttcctgggag gactggcctt cagagtgttt cactgcaccc agtacatcag      900

gcacggctcc aagccaatgt atacaccaga gcccgacatc tgtcacgagc tgctgggcca      960

cgtgcccctg tttagcgata gatccttcgc ccagttttcc caggagatcg gactggcatc     1020

tctgggagca cctgacgagt acatcgagaa gctggccacc atctattggt tcacagtgga     1080

gtttggcctg tgcaagcagg gcgatagcat caaggcctac ggagcaggac tgctgtctag     1140

cttcggcgag ctgcagtatt gtctgtccga gaagccaaag ctgctgcccc tggagctgga     1200

gaagaccgcc atccagaact acaccgtgac agagttccag cccctgtact atgtggccga     1260

gtcttttaac gatgccaagg agaaggtgag aaatttcgcc gccacaatcc ctaggccctt     1320

cagcgtgcgg tacgaccctt atacccagag gatcgaggtg ctggataata cacagcagct     1380

gaagatcctg gctgactcaa tcaatagcga aatcggaatc ctgtgctccg ccctgcagaa     1440

aatcaaatga ggtaccgatc cagacatgat aagatacatt gatgagtttg gacaaaccac     1500

aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt     1560

tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt     1620

tcaggttcag ggggaggtgt gggaggtttt ttaa                                 1654


<210>  36
<211>  960
<212>  DNA
<213>  Homo sapiens

<400>  36
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960


<210>  37
<211>  960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.2 vector 5' homology arm

<400>  37
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccaccatgg cggcggcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960


<210>  38
<211>  960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.3 vector 5' homology arm

<400>  38
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctga gagtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960


<210>  39
<211>  960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.4 vector 5' homology arm

<400>  39
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgagtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960


<210>  40
<211>  960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.5 vector 5' homology arm

<400>  40
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acgtcaagca      480

tccggcaggc tgccctggcc tcctgagtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960


<210>  41
<211>  960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.6 vector 5' homology arm

<400>  41
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaatg tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960


<210>  42
<211>  960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.7 vector 5' homology arm

<400>  42
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttccaccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960


<210>  43
<211>  968
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.8 vector 5' homology arm

<400>  43
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttccaccag acggtcgcag gcttagtcca attgcagaga acacgctgtt      300

cttcgcccca ggcttctgag agtcccggaa gtgcctaaac ctgtctaatc gacggggctt      360

gggtggcccg tcgctccctg gcttcttccc tttacccagg gcgggcagcg aagtggtgcc      420

tcctgcgtcc cccacaccct ccctcagccc ctcccctccg gcccgtcctg ggcaggtgac      480

ctggagcatc cggcaggctg ccctggcctc ctgcgtcagg acaacgccca cgaggggcgt      540

tactgtgcgg agatgcacca cgcaagagac accctttgta actctcttct cctccctagt      600

gcgaggttaa aaccttcagc cccacgtgct gtttgcaaac ctgcctgtac ctgaggccct      660

aaaaagccag agacctcact cccggggagc cagcatgtcc actgcggtcc tggaaaaccc      720

aggcttgggc aggaaactct ctgactttgg acaggtgagc cacggcagcc tgagctgctc      780

agttagggga atttgggcct ccagagaaag agatccgaag actgctggtg cttcctggtt      840

tcataagctc agtaagaagt ctgaattcgt tggaagctga tgagaatatc caggaagtca      900

acagacaaat gtcctcaaca attgtttcta agtaggagaa catctgtcct cggtggcttt      960

cacaggaa                                                               968


<210>  44
<211>  960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.9 vector 5' homology arm

<400>  44
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctga gagtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacagagc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc taggcaggtg acctgaagca      480

tccagcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960


<210>  45
<211>  911
<212>  DNA
<213>  Homo sapiens

<400>  45
ctgggatggg atgtggaatc cttctagatt tcttttgtaa tatttataaa gtgctctcag       60

caaggtatca aaatggcaaa attgtgagta actatcctcc tttcattttg ggaagaagat      120

gaggcatgaa gagaattcag acagaaactt actcagacca ggggaggcag aaactaagca      180

gagaggaaaa tgaccaagag ttagccctgg gcatggaatg tgaaagaacc ctaaacgtga      240

cttggaaata atgcccaagg tatattccat tctccgggat ttgttggcat tttcttgagg      300

tgaagaattg cagaatacat tctttaatgt gacctacata tttacccatg ggaggaagtc      360

tgctcctgga ctcttgagat tcagtcataa agcccaggcc agggaaataa tgtaagtctg      420

caggcccctg tcatcagtag gattagggag aagagttctc agtagaaaac agggaggctg      480

gagagaaaag aatggttaat gttaacgtta atataactag aaagactgca gaacttagga      540

ctgattttta tttgaatcct taaaaaaaaa aatttcttat gaaaatagta catggctctt      600

aggagacaga acttattgta cagaggaaca gcgtgagagt cagagtgatc ccagaacagg      660

tcctggctcc atcctgcaca tagttttggt gctgctggca atacggtccc cacaactgtg      720

ggaaggggtt aggggcaggg atctcatcag gaaagcatag gggtttaaag ttctttatag      780

agcacttaga agattgagaa tccacaaatt atattaataa caaacaaagt agtgtcgtgt      840

tatatagtaa atgtgaattt gcagacacat ttagggaaaa gttataatta aaaaaatagg      900

ctgtatatat a                                                           911


<210>  46
<211>  3537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.1 vector correction genome

<400>  46
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960

aagcttctga cctcttctct tcctcccaca gggcagcgga gctactaact tcagcctgct     1020

gaagcaggct ggagacgtgg aggagaaccc tggacctatg tccaccgctg tgctggagaa     1080

ccctgggctg gggaggaaac tgtcagactt cgggcaggag acttcataca ttgaggataa     1140

ctgtaaccag aatggcgcca tctctctgat cttcagcctg aaggaggaag tgggcgccct     1200

ggcaaaggtg ctgcgcctgt ttgaggagaa cgacgtgaat ctgacccaca tcgagtcccg     1260

gccttctaga ctgaagaagg acgagtacga gttctttacc cacctggata agcggtccct     1320

gccagccctg acaaacatca tcaagatcct gaggcacgac atcggagcaa ccgtgcacga     1380

gctgtctcgg gacaagaaga aggataccgt gccctggttc cctcggacaa tccaggagct     1440

ggatagattt gccaaccaga tcctgtctta cggagcagag ctggacgcag atcaccctgg     1500

cttcaaggac ccagtgtatc gggcccggag aaagcagttt gccgatatcg cctacaatta     1560

taggcacgga cagccaatcc ctcgcgtgga gtatatggag gaggagaaga agacctgggg     1620

cacagtgttc aagaccctga agagcctgta caagacacac gcctgctacg agtataacca     1680

catcttcccc ctgctggaga agtattgtgg ctttcacgag gacaatatcc ctcagctgga     1740

ggacgtgagc cagttcctgc agacctgcac aggctttagg ctgaggccag tggcaggact     1800

gctgagctcc cgggacttcc tgggaggact ggccttcaga gtgtttcact gcacccagta     1860

catcaggcac ggctccaagc caatgtatac accagagccc gacatctgtc acgagctgct     1920

gggccacgtg cccctgttta gcgatagatc cttcgcccag ttttcccagg agatcggact     1980

ggcatctctg ggagcacctg acgagtacat cgagaagctg gccaccatct attggttcac     2040

agtggagttt ggcctgtgca agcagggcga tagcatcaag gcctacggag caggactgct     2100

gtctagcttc ggcgagctgc agtattgtct gtccgagaag ccaaagctgc tgcccctgga     2160

gctggagaag accgccatcc agaactacac cgtgacagag ttccagcccc tgtactatgt     2220

ggccgagtct tttaacgatg ccaaggagaa ggtgagaaat ttcgccgcca caatccctag     2280

gcccttcagc gtgcggtacg acccttatac ccagaggatc gaggtgctgg ataatacaca     2340

gcagctgaag atcctggctg actcaatcaa tagcgaaatc ggaatcctgt gctccgccct     2400

gcagaaaatc aaatgaggta ccgatccaga catgataaga tacattgatg agtttggaca     2460

aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc     2520

tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt     2580

tatgtttcag gttcaggggg aggtgtggga ggttttttaa ggatccctgg gatgggatgt     2640

ggaatccttc tagatttctt ttgtaatatt tataaagtgc tctcagcaag gtatcaaaat     2700

ggcaaaattg tgagtaacta tcctcctttc attttgggaa gaagatgagg catgaagaga     2760

attcagacag aaacttactc agaccagggg aggcagaaac taagcagaga ggaaaatgac     2820

caagagttag ccctgggcat ggaatgtgaa agaaccctaa acgtgacttg gaaataatgc     2880

ccaaggtata ttccattctc cgggatttgt tggcattttc ttgaggtgaa gaattgcaga     2940

atacattctt taatgtgacc tacatattta cccatgggag gaagtctgct cctggactct     3000

tgagattcag tcataaagcc caggccaggg aaataatgta agtctgcagg cccctgtcat     3060

cagtaggatt agggagaaga gttctcagta gaaaacaggg aggctggaga gaaaagaatg     3120

gttaatgtta acgttaatat aactagaaag actgcagaac ttaggactga tttttatttg     3180

aatccttaaa aaaaaaaatt tcttatgaaa atagtacatg gctcttagga gacagaactt     3240

attgtacaga ggaacagcgt gagagtcaga gtgatcccag aacaggtcct ggctccatcc     3300

tgcacatagt tttggtgctg ctggcaatac ggtccccaca actgtgggaa ggggttaggg     3360

gcagggatct catcaggaaa gcataggggt ttaaagttct ttatagagca cttagaagat     3420

tgagaatcca caaattatat taataacaaa caaagtagtg tcgtgttata tagtaaatgt     3480

gaatttgcag acacatttag ggaaaagtta taattaaaaa aataggctgt atatata        3537


<210>  47
<211>  3537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.2 vector correction genome

<400>  47
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccaccatgg cggcggcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960

aagcttctga cctcttctct tcctcccaca gggcagcgga gctactaact tcagcctgct     1020

gaagcaggct ggagacgtgg aggagaaccc tggacctatg tccaccgctg tgctggagaa     1080

ccctgggctg gggaggaaac tgtcagactt cgggcaggag acttcataca ttgaggataa     1140

ctgtaaccag aatggcgcca tctctctgat cttcagcctg aaggaggaag tgggcgccct     1200

ggcaaaggtg ctgcgcctgt ttgaggagaa cgacgtgaat ctgacccaca tcgagtcccg     1260

gccttctaga ctgaagaagg acgagtacga gttctttacc cacctggata agcggtccct     1320

gccagccctg acaaacatca tcaagatcct gaggcacgac atcggagcaa ccgtgcacga     1380

gctgtctcgg gacaagaaga aggataccgt gccctggttc cctcggacaa tccaggagct     1440

ggatagattt gccaaccaga tcctgtctta cggagcagag ctggacgcag atcaccctgg     1500

cttcaaggac ccagtgtatc gggcccggag aaagcagttt gccgatatcg cctacaatta     1560

taggcacgga cagccaatcc ctcgcgtgga gtatatggag gaggagaaga agacctgggg     1620

cacagtgttc aagaccctga agagcctgta caagacacac gcctgctacg agtataacca     1680

catcttcccc ctgctggaga agtattgtgg ctttcacgag gacaatatcc ctcagctgga     1740

ggacgtgagc cagttcctgc agacctgcac aggctttagg ctgaggccag tggcaggact     1800

gctgagctcc cgggacttcc tgggaggact ggccttcaga gtgtttcact gcacccagta     1860

catcaggcac ggctccaagc caatgtatac accagagccc gacatctgtc acgagctgct     1920

gggccacgtg cccctgttta gcgatagatc cttcgcccag ttttcccagg agatcggact     1980

ggcatctctg ggagcacctg acgagtacat cgagaagctg gccaccatct attggttcac     2040

agtggagttt ggcctgtgca agcagggcga tagcatcaag gcctacggag caggactgct     2100

gtctagcttc ggcgagctgc agtattgtct gtccgagaag ccaaagctgc tgcccctgga     2160

gctggagaag accgccatcc agaactacac cgtgacagag ttccagcccc tgtactatgt     2220

ggccgagtct tttaacgatg ccaaggagaa ggtgagaaat ttcgccgcca caatccctag     2280

gcccttcagc gtgcggtacg acccttatac ccagaggatc gaggtgctgg ataatacaca     2340

gcagctgaag atcctggctg actcaatcaa tagcgaaatc ggaatcctgt gctccgccct     2400

gcagaaaatc aaatgaggta ccgatccaga catgataaga tacattgatg agtttggaca     2460

aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc     2520

tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt     2580

tatgtttcag gttcaggggg aggtgtggga ggttttttaa ggatccctgg gatgggatgt     2640

ggaatccttc tagatttctt ttgtaatatt tataaagtgc tctcagcaag gtatcaaaat     2700

ggcaaaattg tgagtaacta tcctcctttc attttgggaa gaagatgagg catgaagaga     2760

attcagacag aaacttactc agaccagggg aggcagaaac taagcagaga ggaaaatgac     2820

caagagttag ccctgggcat ggaatgtgaa agaaccctaa acgtgacttg gaaataatgc     2880

ccaaggtata ttccattctc cgggatttgt tggcattttc ttgaggtgaa gaattgcaga     2940

atacattctt taatgtgacc tacatattta cccatgggag gaagtctgct cctggactct     3000

tgagattcag tcataaagcc caggccaggg aaataatgta agtctgcagg cccctgtcat     3060

cagtaggatt agggagaaga gttctcagta gaaaacaggg aggctggaga gaaaagaatg     3120

gttaatgtta acgttaatat aactagaaag actgcagaac ttaggactga tttttatttg     3180

aatccttaaa aaaaaaaatt tcttatgaaa atagtacatg gctcttagga gacagaactt     3240

attgtacaga ggaacagcgt gagagtcaga gtgatcccag aacaggtcct ggctccatcc     3300

tgcacatagt tttggtgctg ctggcaatac ggtccccaca actgtgggaa ggggttaggg     3360

gcagggatct catcaggaaa gcataggggt ttaaagttct ttatagagca cttagaagat     3420

tgagaatcca caaattatat taataacaaa caaagtagtg tcgtgttata tagtaaatgt     3480

gaatttgcag acacatttag ggaaaagtta taattaaaaa aataggctgt atatata        3537


<210>  48
<211>  3537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.3 vector correction genome

<400>  48
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctga gagtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960

aagcttctga cctcttctct tcctcccaca gggcagcgga gctactaact tcagcctgct     1020

gaagcaggct ggagacgtgg aggagaaccc tggacctatg tccaccgctg tgctggagaa     1080

ccctgggctg gggaggaaac tgtcagactt cgggcaggag acttcataca ttgaggataa     1140

ctgtaaccag aatggcgcca tctctctgat cttcagcctg aaggaggaag tgggcgccct     1200

ggcaaaggtg ctgcgcctgt ttgaggagaa cgacgtgaat ctgacccaca tcgagtcccg     1260

gccttctaga ctgaagaagg acgagtacga gttctttacc cacctggata agcggtccct     1320

gccagccctg acaaacatca tcaagatcct gaggcacgac atcggagcaa ccgtgcacga     1380

gctgtctcgg gacaagaaga aggataccgt gccctggttc cctcggacaa tccaggagct     1440

ggatagattt gccaaccaga tcctgtctta cggagcagag ctggacgcag atcaccctgg     1500

cttcaaggac ccagtgtatc gggcccggag aaagcagttt gccgatatcg cctacaatta     1560

taggcacgga cagccaatcc ctcgcgtgga gtatatggag gaggagaaga agacctgggg     1620

cacagtgttc aagaccctga agagcctgta caagacacac gcctgctacg agtataacca     1680

catcttcccc ctgctggaga agtattgtgg ctttcacgag gacaatatcc ctcagctgga     1740

ggacgtgagc cagttcctgc agacctgcac aggctttagg ctgaggccag tggcaggact     1800

gctgagctcc cgggacttcc tgggaggact ggccttcaga gtgtttcact gcacccagta     1860

catcaggcac ggctccaagc caatgtatac accagagccc gacatctgtc acgagctgct     1920

gggccacgtg cccctgttta gcgatagatc cttcgcccag ttttcccagg agatcggact     1980

ggcatctctg ggagcacctg acgagtacat cgagaagctg gccaccatct attggttcac     2040

agtggagttt ggcctgtgca agcagggcga tagcatcaag gcctacggag caggactgct     2100

gtctagcttc ggcgagctgc agtattgtct gtccgagaag ccaaagctgc tgcccctgga     2160

gctggagaag accgccatcc agaactacac cgtgacagag ttccagcccc tgtactatgt     2220

ggccgagtct tttaacgatg ccaaggagaa ggtgagaaat ttcgccgcca caatccctag     2280

gcccttcagc gtgcggtacg acccttatac ccagaggatc gaggtgctgg ataatacaca     2340

gcagctgaag atcctggctg actcaatcaa tagcgaaatc ggaatcctgt gctccgccct     2400

gcagaaaatc aaatgaggta ccgatccaga catgataaga tacattgatg agtttggaca     2460

aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc     2520

tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt     2580

tatgtttcag gttcaggggg aggtgtggga ggttttttaa ggatccctgg gatgggatgt     2640

ggaatccttc tagatttctt ttgtaatatt tataaagtgc tctcagcaag gtatcaaaat     2700

ggcaaaattg tgagtaacta tcctcctttc attttgggaa gaagatgagg catgaagaga     2760

attcagacag aaacttactc agaccagggg aggcagaaac taagcagaga ggaaaatgac     2820

caagagttag ccctgggcat ggaatgtgaa agaaccctaa acgtgacttg gaaataatgc     2880

ccaaggtata ttccattctc cgggatttgt tggcattttc ttgaggtgaa gaattgcaga     2940

atacattctt taatgtgacc tacatattta cccatgggag gaagtctgct cctggactct     3000

tgagattcag tcataaagcc caggccaggg aaataatgta agtctgcagg cccctgtcat     3060

cagtaggatt agggagaaga gttctcagta gaaaacaggg aggctggaga gaaaagaatg     3120

gttaatgtta acgttaatat aactagaaag actgcagaac ttaggactga tttttatttg     3180

aatccttaaa aaaaaaaatt tcttatgaaa atagtacatg gctcttagga gacagaactt     3240

attgtacaga ggaacagcgt gagagtcaga gtgatcccag aacaggtcct ggctccatcc     3300

tgcacatagt tttggtgctg ctggcaatac ggtccccaca actgtgggaa ggggttaggg     3360

gcagggatct catcaggaaa gcataggggt ttaaagttct ttatagagca cttagaagat     3420

tgagaatcca caaattatat taataacaaa caaagtagtg tcgtgttata tagtaaatgt     3480

gaatttgcag acacatttag ggaaaagtta taattaaaaa aataggctgt atatata        3537


<210>  49
<211>  3537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.4 vector correction genome

<400>  49
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgagtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960

aagcttctga cctcttctct tcctcccaca gggcagcgga gctactaact tcagcctgct     1020

gaagcaggct ggagacgtgg aggagaaccc tggacctatg tccaccgctg tgctggagaa     1080

ccctgggctg gggaggaaac tgtcagactt cgggcaggag acttcataca ttgaggataa     1140

ctgtaaccag aatggcgcca tctctctgat cttcagcctg aaggaggaag tgggcgccct     1200

ggcaaaggtg ctgcgcctgt ttgaggagaa cgacgtgaat ctgacccaca tcgagtcccg     1260

gccttctaga ctgaagaagg acgagtacga gttctttacc cacctggata agcggtccct     1320

gccagccctg acaaacatca tcaagatcct gaggcacgac atcggagcaa ccgtgcacga     1380

gctgtctcgg gacaagaaga aggataccgt gccctggttc cctcggacaa tccaggagct     1440

ggatagattt gccaaccaga tcctgtctta cggagcagag ctggacgcag atcaccctgg     1500

cttcaaggac ccagtgtatc gggcccggag aaagcagttt gccgatatcg cctacaatta     1560

taggcacgga cagccaatcc ctcgcgtgga gtatatggag gaggagaaga agacctgggg     1620

cacagtgttc aagaccctga agagcctgta caagacacac gcctgctacg agtataacca     1680

catcttcccc ctgctggaga agtattgtgg ctttcacgag gacaatatcc ctcagctgga     1740

ggacgtgagc cagttcctgc agacctgcac aggctttagg ctgaggccag tggcaggact     1800

gctgagctcc cgggacttcc tgggaggact ggccttcaga gtgtttcact gcacccagta     1860

catcaggcac ggctccaagc caatgtatac accagagccc gacatctgtc acgagctgct     1920

gggccacgtg cccctgttta gcgatagatc cttcgcccag ttttcccagg agatcggact     1980

ggcatctctg ggagcacctg acgagtacat cgagaagctg gccaccatct attggttcac     2040

agtggagttt ggcctgtgca agcagggcga tagcatcaag gcctacggag caggactgct     2100

gtctagcttc ggcgagctgc agtattgtct gtccgagaag ccaaagctgc tgcccctgga     2160

gctggagaag accgccatcc agaactacac cgtgacagag ttccagcccc tgtactatgt     2220

ggccgagtct tttaacgatg ccaaggagaa ggtgagaaat ttcgccgcca caatccctag     2280

gcccttcagc gtgcggtacg acccttatac ccagaggatc gaggtgctgg ataatacaca     2340

gcagctgaag atcctggctg actcaatcaa tagcgaaatc ggaatcctgt gctccgccct     2400

gcagaaaatc aaatgaggta ccgatccaga catgataaga tacattgatg agtttggaca     2460

aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc     2520

tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt     2580

tatgtttcag gttcaggggg aggtgtggga ggttttttaa ggatccctgg gatgggatgt     2640

ggaatccttc tagatttctt ttgtaatatt tataaagtgc tctcagcaag gtatcaaaat     2700

ggcaaaattg tgagtaacta tcctcctttc attttgggaa gaagatgagg catgaagaga     2760

attcagacag aaacttactc agaccagggg aggcagaaac taagcagaga ggaaaatgac     2820

caagagttag ccctgggcat ggaatgtgaa agaaccctaa acgtgacttg gaaataatgc     2880

ccaaggtata ttccattctc cgggatttgt tggcattttc ttgaggtgaa gaattgcaga     2940

atacattctt taatgtgacc tacatattta cccatgggag gaagtctgct cctggactct     3000

tgagattcag tcataaagcc caggccaggg aaataatgta agtctgcagg cccctgtcat     3060

cagtaggatt agggagaaga gttctcagta gaaaacaggg aggctggaga gaaaagaatg     3120

gttaatgtta acgttaatat aactagaaag actgcagaac ttaggactga tttttatttg     3180

aatccttaaa aaaaaaaatt tcttatgaaa atagtacatg gctcttagga gacagaactt     3240

attgtacaga ggaacagcgt gagagtcaga gtgatcccag aacaggtcct ggctccatcc     3300

tgcacatagt tttggtgctg ctggcaatac ggtccccaca actgtgggaa ggggttaggg     3360

gcagggatct catcaggaaa gcataggggt ttaaagttct ttatagagca cttagaagat     3420

tgagaatcca caaattatat taataacaaa caaagtagtg tcgtgttata tagtaaatgt     3480

gaatttgcag acacatttag ggaaaagtta taattaaaaa aataggctgt atatata        3537


<210>  50
<211>  3537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.5 vector correction genome

<400>  50
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acgtcaagca      480

tccggcaggc tgccctggcc tcctgagtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960

aagcttctga cctcttctct tcctcccaca gggcagcgga gctactaact tcagcctgct     1020

gaagcaggct ggagacgtgg aggagaaccc tggacctatg tccaccgctg tgctggagaa     1080

ccctgggctg gggaggaaac tgtcagactt cgggcaggag acttcataca ttgaggataa     1140

ctgtaaccag aatggcgcca tctctctgat cttcagcctg aaggaggaag tgggcgccct     1200

ggcaaaggtg ctgcgcctgt ttgaggagaa cgacgtgaat ctgacccaca tcgagtcccg     1260

gccttctaga ctgaagaagg acgagtacga gttctttacc cacctggata agcggtccct     1320

gccagccctg acaaacatca tcaagatcct gaggcacgac atcggagcaa ccgtgcacga     1380

gctgtctcgg gacaagaaga aggataccgt gccctggttc cctcggacaa tccaggagct     1440

ggatagattt gccaaccaga tcctgtctta cggagcagag ctggacgcag atcaccctgg     1500

cttcaaggac ccagtgtatc gggcccggag aaagcagttt gccgatatcg cctacaatta     1560

taggcacgga cagccaatcc ctcgcgtgga gtatatggag gaggagaaga agacctgggg     1620

cacagtgttc aagaccctga agagcctgta caagacacac gcctgctacg agtataacca     1680

catcttcccc ctgctggaga agtattgtgg ctttcacgag gacaatatcc ctcagctgga     1740

ggacgtgagc cagttcctgc agacctgcac aggctttagg ctgaggccag tggcaggact     1800

gctgagctcc cgggacttcc tgggaggact ggccttcaga gtgtttcact gcacccagta     1860

catcaggcac ggctccaagc caatgtatac accagagccc gacatctgtc acgagctgct     1920

gggccacgtg cccctgttta gcgatagatc cttcgcccag ttttcccagg agatcggact     1980

ggcatctctg ggagcacctg acgagtacat cgagaagctg gccaccatct attggttcac     2040

agtggagttt ggcctgtgca agcagggcga tagcatcaag gcctacggag caggactgct     2100

gtctagcttc ggcgagctgc agtattgtct gtccgagaag ccaaagctgc tgcccctgga     2160

gctggagaag accgccatcc agaactacac cgtgacagag ttccagcccc tgtactatgt     2220

ggccgagtct tttaacgatg ccaaggagaa ggtgagaaat ttcgccgcca caatccctag     2280

gcccttcagc gtgcggtacg acccttatac ccagaggatc gaggtgctgg ataatacaca     2340

gcagctgaag atcctggctg actcaatcaa tagcgaaatc ggaatcctgt gctccgccct     2400

gcagaaaatc aaatgaggta ccgatccaga catgataaga tacattgatg agtttggaca     2460

aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc     2520

tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt     2580

tatgtttcag gttcaggggg aggtgtggga ggttttttaa ggatccctgg gatgggatgt     2640

ggaatccttc tagatttctt ttgtaatatt tataaagtgc tctcagcaag gtatcaaaat     2700

ggcaaaattg tgagtaacta tcctcctttc attttgggaa gaagatgagg catgaagaga     2760

attcagacag aaacttactc agaccagggg aggcagaaac taagcagaga ggaaaatgac     2820

caagagttag ccctgggcat ggaatgtgaa agaaccctaa acgtgacttg gaaataatgc     2880

ccaaggtata ttccattctc cgggatttgt tggcattttc ttgaggtgaa gaattgcaga     2940

atacattctt taatgtgacc tacatattta cccatgggag gaagtctgct cctggactct     3000

tgagattcag tcataaagcc caggccaggg aaataatgta agtctgcagg cccctgtcat     3060

cagtaggatt agggagaaga gttctcagta gaaaacaggg aggctggaga gaaaagaatg     3120

gttaatgtta acgttaatat aactagaaag actgcagaac ttaggactga tttttatttg     3180

aatccttaaa aaaaaaaatt tcttatgaaa atagtacatg gctcttagga gacagaactt     3240

attgtacaga ggaacagcgt gagagtcaga gtgatcccag aacaggtcct ggctccatcc     3300

tgcacatagt tttggtgctg ctggcaatac ggtccccaca actgtgggaa ggggttaggg     3360

gcagggatct catcaggaaa gcataggggt ttaaagttct ttatagagca cttagaagat     3420

tgagaatcca caaattatat taataacaaa caaagtagtg tcgtgttata tagtaaatgt     3480

gaatttgcag acacatttag ggaaaagtta taattaaaaa aataggctgt atatata        3537


<210>  51
<211>  3537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.6 vector correction genome

<400>  51
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaatg tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960

aagcttctga cctcttctct tcctcccaca gggcagcgga gctactaact tcagcctgct     1020

gaagcaggct ggagacgtgg aggagaaccc tggacctatg tccaccgctg tgctggagaa     1080

ccctgggctg gggaggaaac tgtcagactt cgggcaggag acttcataca ttgaggataa     1140

ctgtaaccag aatggcgcca tctctctgat cttcagcctg aaggaggaag tgggcgccct     1200

ggcaaaggtg ctgcgcctgt ttgaggagaa cgacgtgaat ctgacccaca tcgagtcccg     1260

gccttctaga ctgaagaagg acgagtacga gttctttacc cacctggata agcggtccct     1320

gccagccctg acaaacatca tcaagatcct gaggcacgac atcggagcaa ccgtgcacga     1380

gctgtctcgg gacaagaaga aggataccgt gccctggttc cctcggacaa tccaggagct     1440

ggatagattt gccaaccaga tcctgtctta cggagcagag ctggacgcag atcaccctgg     1500

cttcaaggac ccagtgtatc gggcccggag aaagcagttt gccgatatcg cctacaatta     1560

taggcacgga cagccaatcc ctcgcgtgga gtatatggag gaggagaaga agacctgggg     1620

cacagtgttc aagaccctga agagcctgta caagacacac gcctgctacg agtataacca     1680

catcttcccc ctgctggaga agtattgtgg ctttcacgag gacaatatcc ctcagctgga     1740

ggacgtgagc cagttcctgc agacctgcac aggctttagg ctgaggccag tggcaggact     1800

gctgagctcc cgggacttcc tgggaggact ggccttcaga gtgtttcact gcacccagta     1860

catcaggcac ggctccaagc caatgtatac accagagccc gacatctgtc acgagctgct     1920

gggccacgtg cccctgttta gcgatagatc cttcgcccag ttttcccagg agatcggact     1980

ggcatctctg ggagcacctg acgagtacat cgagaagctg gccaccatct attggttcac     2040

agtggagttt ggcctgtgca agcagggcga tagcatcaag gcctacggag caggactgct     2100

gtctagcttc ggcgagctgc agtattgtct gtccgagaag ccaaagctgc tgcccctgga     2160

gctggagaag accgccatcc agaactacac cgtgacagag ttccagcccc tgtactatgt     2220

ggccgagtct tttaacgatg ccaaggagaa ggtgagaaat ttcgccgcca caatccctag     2280

gcccttcagc gtgcggtacg acccttatac ccagaggatc gaggtgctgg ataatacaca     2340

gcagctgaag atcctggctg actcaatcaa tagcgaaatc ggaatcctgt gctccgccct     2400

gcagaaaatc aaatgaggta ccgatccaga catgataaga tacattgatg agtttggaca     2460

aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc     2520

tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt     2580

tatgtttcag gttcaggggg aggtgtggga ggttttttaa ggatccctgg gatgggatgt     2640

ggaatccttc tagatttctt ttgtaatatt tataaagtgc tctcagcaag gtatcaaaat     2700

ggcaaaattg tgagtaacta tcctcctttc attttgggaa gaagatgagg catgaagaga     2760

attcagacag aaacttactc agaccagggg aggcagaaac taagcagaga ggaaaatgac     2820

caagagttag ccctgggcat ggaatgtgaa agaaccctaa acgtgacttg gaaataatgc     2880

ccaaggtata ttccattctc cgggatttgt tggcattttc ttgaggtgaa gaattgcaga     2940

atacattctt taatgtgacc tacatattta cccatgggag gaagtctgct cctggactct     3000

tgagattcag tcataaagcc caggccaggg aaataatgta agtctgcagg cccctgtcat     3060

cagtaggatt agggagaaga gttctcagta gaaaacaggg aggctggaga gaaaagaatg     3120

gttaatgtta acgttaatat aactagaaag actgcagaac ttaggactga tttttatttg     3180

aatccttaaa aaaaaaaatt tcttatgaaa atagtacatg gctcttagga gacagaactt     3240

attgtacaga ggaacagcgt gagagtcaga gtgatcccag aacaggtcct ggctccatcc     3300

tgcacatagt tttggtgctg ctggcaatac ggtccccaca actgtgggaa ggggttaggg     3360

gcagggatct catcaggaaa gcataggggt ttaaagttct ttatagagca cttagaagat     3420

tgagaatcca caaattatat taataacaaa caaagtagtg tcgtgttata tagtaaatgt     3480

gaatttgcag acacatttag ggaaaagtta taattaaaaa aataggctgt atatata        3537


<210>  52
<211>  3537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.7 vector correction genome

<400>  52
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttccaccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960

aagcttctga cctcttctct tcctcccaca gggcagcgga gctactaact tcagcctgct     1020

gaagcaggct ggagacgtgg aggagaaccc tggacctatg tccaccgctg tgctggagaa     1080

ccctgggctg gggaggaaac tgtcagactt cgggcaggag acttcataca ttgaggataa     1140

ctgtaaccag aatggcgcca tctctctgat cttcagcctg aaggaggaag tgggcgccct     1200

ggcaaaggtg ctgcgcctgt ttgaggagaa cgacgtgaat ctgacccaca tcgagtcccg     1260

gccttctaga ctgaagaagg acgagtacga gttctttacc cacctggata agcggtccct     1320

gccagccctg acaaacatca tcaagatcct gaggcacgac atcggagcaa ccgtgcacga     1380

gctgtctcgg gacaagaaga aggataccgt gccctggttc cctcggacaa tccaggagct     1440

ggatagattt gccaaccaga tcctgtctta cggagcagag ctggacgcag atcaccctgg     1500

cttcaaggac ccagtgtatc gggcccggag aaagcagttt gccgatatcg cctacaatta     1560

taggcacgga cagccaatcc ctcgcgtgga gtatatggag gaggagaaga agacctgggg     1620

cacagtgttc aagaccctga agagcctgta caagacacac gcctgctacg agtataacca     1680

catcttcccc ctgctggaga agtattgtgg ctttcacgag gacaatatcc ctcagctgga     1740

ggacgtgagc cagttcctgc agacctgcac aggctttagg ctgaggccag tggcaggact     1800

gctgagctcc cgggacttcc tgggaggact ggccttcaga gtgtttcact gcacccagta     1860

catcaggcac ggctccaagc caatgtatac accagagccc gacatctgtc acgagctgct     1920

gggccacgtg cccctgttta gcgatagatc cttcgcccag ttttcccagg agatcggact     1980

ggcatctctg ggagcacctg acgagtacat cgagaagctg gccaccatct attggttcac     2040

agtggagttt ggcctgtgca agcagggcga tagcatcaag gcctacggag caggactgct     2100

gtctagcttc ggcgagctgc agtattgtct gtccgagaag ccaaagctgc tgcccctgga     2160

gctggagaag accgccatcc agaactacac cgtgacagag ttccagcccc tgtactatgt     2220

ggccgagtct tttaacgatg ccaaggagaa ggtgagaaat ttcgccgcca caatccctag     2280

gcccttcagc gtgcggtacg acccttatac ccagaggatc gaggtgctgg ataatacaca     2340

gcagctgaag atcctggctg actcaatcaa tagcgaaatc ggaatcctgt gctccgccct     2400

gcagaaaatc aaatgaggta ccgatccaga catgataaga tacattgatg agtttggaca     2460

aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc     2520

tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt     2580

tatgtttcag gttcaggggg aggtgtggga ggttttttaa ggatccctgg gatgggatgt     2640

ggaatccttc tagatttctt ttgtaatatt tataaagtgc tctcagcaag gtatcaaaat     2700

ggcaaaattg tgagtaacta tcctcctttc attttgggaa gaagatgagg catgaagaga     2760

attcagacag aaacttactc agaccagggg aggcagaaac taagcagaga ggaaaatgac     2820

caagagttag ccctgggcat ggaatgtgaa agaaccctaa acgtgacttg gaaataatgc     2880

ccaaggtata ttccattctc cgggatttgt tggcattttc ttgaggtgaa gaattgcaga     2940

atacattctt taatgtgacc tacatattta cccatgggag gaagtctgct cctggactct     3000

tgagattcag tcataaagcc caggccaggg aaataatgta agtctgcagg cccctgtcat     3060

cagtaggatt agggagaaga gttctcagta gaaaacaggg aggctggaga gaaaagaatg     3120

gttaatgtta acgttaatat aactagaaag actgcagaac ttaggactga tttttatttg     3180

aatccttaaa aaaaaaaatt tcttatgaaa atagtacatg gctcttagga gacagaactt     3240

attgtacaga ggaacagcgt gagagtcaga gtgatcccag aacaggtcct ggctccatcc     3300

tgcacatagt tttggtgctg ctggcaatac ggtccccaca actgtgggaa ggggttaggg     3360

gcagggatct catcaggaaa gcataggggt ttaaagttct ttatagagca cttagaagat     3420

tgagaatcca caaattatat taataacaaa caaagtagtg tcgtgttata tagtaaatgt     3480

gaatttgcag acacatttag ggaaaagtta taattaaaaa aataggctgt atatata        3537


<210>  53
<211>  3545
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.8 vector correction genome

<400>  53
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttccaccag acggtcgcag gcttagtcca attgcagaga acacgctgtt      300

cttcgcccca ggcttctgag agtcccggaa gtgcctaaac ctgtctaatc gacggggctt      360

gggtggcccg tcgctccctg gcttcttccc tttacccagg gcgggcagcg aagtggtgcc      420

tcctgcgtcc cccacaccct ccctcagccc ctcccctccg gcccgtcctg ggcaggtgac      480

ctggagcatc cggcaggctg ccctggcctc ctgcgtcagg acaacgccca cgaggggcgt      540

tactgtgcgg agatgcacca cgcaagagac accctttgta actctcttct cctccctagt      600

gcgaggttaa aaccttcagc cccacgtgct gtttgcaaac ctgcctgtac ctgaggccct      660

aaaaagccag agacctcact cccggggagc cagcatgtcc actgcggtcc tggaaaaccc      720

aggcttgggc aggaaactct ctgactttgg acaggtgagc cacggcagcc tgagctgctc      780

agttagggga atttgggcct ccagagaaag agatccgaag actgctggtg cttcctggtt      840

tcataagctc agtaagaagt ctgaattcgt tggaagctga tgagaatatc caggaagtca      900

acagacaaat gtcctcaaca attgtttcta agtaggagaa catctgtcct cggtggcttt      960

cacaggaaaa gcttctgacc tcttctcttc ctcccacagg gcagcggagc tactaacttc     1020

agcctgctga agcaggctgg agacgtggag gagaaccctg gacctatgtc caccgctgtg     1080

ctggagaacc ctgggctggg gaggaaactg tcagacttcg ggcaggagac ttcatacatt     1140

gaggataact gtaaccagaa tggcgccatc tctctgatct tcagcctgaa ggaggaagtg     1200

ggcgccctgg caaaggtgct gcgcctgttt gaggagaacg acgtgaatct gacccacatc     1260

gagtcccggc cttctagact gaagaaggac gagtacgagt tctttaccca cctggataag     1320

cggtccctgc cagccctgac aaacatcatc aagatcctga ggcacgacat cggagcaacc     1380

gtgcacgagc tgtctcggga caagaagaag gataccgtgc cctggttccc tcggacaatc     1440

caggagctgg atagatttgc caaccagatc ctgtcttacg gagcagagct ggacgcagat     1500

caccctggct tcaaggaccc agtgtatcgg gcccggagaa agcagtttgc cgatatcgcc     1560

tacaattata ggcacggaca gccaatccct cgcgtggagt atatggagga ggagaagaag     1620

acctggggca cagtgttcaa gaccctgaag agcctgtaca agacacacgc ctgctacgag     1680

tataaccaca tcttccccct gctggagaag tattgtggct ttcacgagga caatatccct     1740

cagctggagg acgtgagcca gttcctgcag acctgcacag gctttaggct gaggccagtg     1800

gcaggactgc tgagctcccg ggacttcctg ggaggactgg ccttcagagt gtttcactgc     1860

acccagtaca tcaggcacgg ctccaagcca atgtatacac cagagcccga catctgtcac     1920

gagctgctgg gccacgtgcc cctgtttagc gatagatcct tcgcccagtt ttcccaggag     1980

atcggactgg catctctggg agcacctgac gagtacatcg agaagctggc caccatctat     2040

tggttcacag tggagtttgg cctgtgcaag cagggcgata gcatcaaggc ctacggagca     2100

ggactgctgt ctagcttcgg cgagctgcag tattgtctgt ccgagaagcc aaagctgctg     2160

cccctggagc tggagaagac cgccatccag aactacaccg tgacagagtt ccagcccctg     2220

tactatgtgg ccgagtcttt taacgatgcc aaggagaagg tgagaaattt cgccgccaca     2280

atccctaggc ccttcagcgt gcggtacgac ccttataccc agaggatcga ggtgctggat     2340

aatacacagc agctgaagat cctggctgac tcaatcaata gcgaaatcgg aatcctgtgc     2400

tccgccctgc agaaaatcaa atgaggtacc gatccagaca tgataagata cattgatgag     2460

tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat     2520

gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc     2580

attcatttta tgtttcaggt tcagggggag gtgtgggagg ttttttaagg atccctggga     2640

tgggatgtgg aatccttcta gatttctttt gtaatattta taaagtgctc tcagcaaggt     2700

atcaaaatgg caaaattgtg agtaactatc ctcctttcat tttgggaaga agatgaggca     2760

tgaagagaat tcagacagaa acttactcag accaggggag gcagaaacta agcagagagg     2820

aaaatgacca agagttagcc ctgggcatgg aatgtgaaag aaccctaaac gtgacttgga     2880

aataatgccc aaggtatatt ccattctccg ggatttgttg gcattttctt gaggtgaaga     2940

attgcagaat acattcttta atgtgaccta catatttacc catgggagga agtctgctcc     3000

tggactcttg agattcagtc ataaagccca ggccagggaa ataatgtaag tctgcaggcc     3060

cctgtcatca gtaggattag ggagaagagt tctcagtaga aaacagggag gctggagaga     3120

aaagaatggt taatgttaac gttaatataa ctagaaagac tgcagaactt aggactgatt     3180

tttatttgaa tccttaaaaa aaaaaatttc ttatgaaaat agtacatggc tcttaggaga     3240

cagaacttat tgtacagagg aacagcgtga gagtcagagt gatcccagaa caggtcctgg     3300

ctccatcctg cacatagttt tggtgctgct ggcaatacgg tccccacaac tgtgggaagg     3360

ggttaggggc agggatctca tcaggaaagc ataggggttt aaagttcttt atagagcact     3420

tagaagattg agaatccaca aattatatta ataacaaaca aagtagtgtc gtgttatata     3480

gtaaatgtga atttgcagac acatttaggg aaaagttata attaaaaaaa taggctgtat     3540

atata                                                                 3545


<210>  54
<211>  3537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.9 vector correction genome

<400>  54
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctga gagtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacagagc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc taggcaggtg acctgaagca      480

tccagcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatccga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960

aagcttctga cctcttctct tcctcccaca gggcagcgga gctactaact tcagcctgct     1020

gaagcaggct ggagacgtgg aggagaaccc tggacctatg tccaccgctg tgctggagaa     1080

ccctgggctg gggaggaaac tgtcagactt cgggcaggag acttcataca ttgaggataa     1140

ctgtaaccag aatggcgcca tctctctgat cttcagcctg aaggaggaag tgggcgccct     1200

ggcaaaggtg ctgcgcctgt ttgaggagaa cgacgtgaat ctgacccaca tcgagtcccg     1260

gccttctaga ctgaagaagg acgagtacga gttctttacc cacctggata agcggtccct     1320

gccagccctg acaaacatca tcaagatcct gaggcacgac atcggagcaa ccgtgcacga     1380

gctgtctcgg gacaagaaga aggataccgt gccctggttc cctcggacaa tccaggagct     1440

ggatagattt gccaaccaga tcctgtctta cggagcagag ctggacgcag atcaccctgg     1500

cttcaaggac ccagtgtatc gggcccggag aaagcagttt gccgatatcg cctacaatta     1560

taggcacgga cagccaatcc ctcgcgtgga gtatatggag gaggagaaga agacctgggg     1620

cacagtgttc aagaccctga agagcctgta caagacacac gcctgctacg agtataacca     1680

catcttcccc ctgctggaga agtattgtgg ctttcacgag gacaatatcc ctcagctgga     1740

ggacgtgagc cagttcctgc agacctgcac aggctttagg ctgaggccag tggcaggact     1800

gctgagctcc cgggacttcc tgggaggact ggccttcaga gtgtttcact gcacccagta     1860

catcaggcac ggctccaagc caatgtatac accagagccc gacatctgtc acgagctgct     1920

gggccacgtg cccctgttta gcgatagatc cttcgcccag ttttcccagg agatcggact     1980

ggcatctctg ggagcacctg acgagtacat cgagaagctg gccaccatct attggttcac     2040

agtggagttt ggcctgtgca agcagggcga tagcatcaag gcctacggag caggactgct     2100

gtctagcttc ggcgagctgc agtattgtct gtccgagaag ccaaagctgc tgcccctgga     2160

gctggagaag accgccatcc agaactacac cgtgacagag ttccagcccc tgtactatgt     2220

ggccgagtct tttaacgatg ccaaggagaa ggtgagaaat ttcgccgcca caatccctag     2280

gcccttcagc gtgcggtacg acccttatac ccagaggatc gaggtgctgg ataatacaca     2340

gcagctgaag atcctggctg actcaatcaa tagcgaaatc ggaatcctgt gctccgccct     2400

gcagaaaatc aaatgaggta ccgatccaga catgataaga tacattgatg agtttggaca     2460

aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc     2520

tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt     2580

tatgtttcag gttcaggggg aggtgtggga ggttttttaa ggatccctgg gatgggatgt     2640

ggaatccttc tagatttctt ttgtaatatt tataaagtgc tctcagcaag gtatcaaaat     2700

ggcaaaattg tgagtaacta tcctcctttc attttgggaa gaagatgagg catgaagaga     2760

attcagacag aaacttactc agaccagggg aggcagaaac taagcagaga ggaaaatgac     2820

caagagttag ccctgggcat ggaatgtgaa agaaccctaa acgtgacttg gaaataatgc     2880

ccaaggtata ttccattctc cgggatttgt tggcattttc ttgaggtgaa gaattgcaga     2940

atacattctt taatgtgacc tacatattta cccatgggag gaagtctgct cctggactct     3000

tgagattcag tcataaagcc caggccaggg aaataatgta agtctgcagg cccctgtcat     3060

cagtaggatt agggagaaga gttctcagta gaaaacaggg aggctggaga gaaaagaatg     3120

gttaatgtta acgttaatat aactagaaag actgcagaac ttaggactga tttttatttg     3180

aatccttaaa aaaaaaaatt tcttatgaaa atagtacatg gctcttagga gacagaactt     3240

attgtacaga ggaacagcgt gagagtcaga gtgatcccag aacaggtcct ggctccatcc     3300

tgcacatagt tttggtgctg ctggcaatac ggtccccaca actgtgggaa ggggttaggg     3360

gcagggatct catcaggaaa gcataggggt ttaaagttct ttatagagca cttagaagat     3420

tgagaatcca caaattatat taataacaaa caaagtagtg tcgtgttata tagtaaatgt     3480

gaatttgcag acacatttag ggaaaagtta taattaaaaa aataggctgt atatata        3537


<210>  55
<211>  3943
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.1 vector correction genome (+ ITRs)

<400>  55
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgct tcaggagcag ttgtgcgaat agctggagaa      240

caccaggctg gatttaaacc cagatcgctc ttacatttgc tctttacctg ctgtgctcag      300

cgttcacgtg ccctctagct gtagttttct gaagtcagcg cacagcaagg cagtgtgctt      360

agaggttaac agaagggaaa acaacaacaa caaaaatcta aatgagaatc ctgactgttt      420

cagctggggg taaggggggc ggattattca tataattgtt ataccagacg gtcgcaggct      480

tagtccaatt gcagagaact cgcttcccag gcttctgaga gtcccggaag tgcctaaacc      540

tgtctaatcg acggggcttg ggtggcccgt cgctccctgg cttcttccct ttacccaggg      600

cgggcagcga agtggtgcct cctgcgtccc ccacaccctc cctcagcccc tcccctccgg      660

cccgtcctgg gcaggtgacc tggagcatcc ggcaggctgc cctggcctcc tgcgtcagga      720

caacgcccac gaggggcgtt actgtgcgga gatgcaccac gcaagagaca ccctttgtaa      780

ctctcttctc ctccctagtg cgaggttaaa accttcagcc ccacgtgctg tttgcaaacc      840

tgcctgtacc tgaggcccta aaaagccaga gacctcactc ccggggagcc agcatgtcca      900

ctgcggtcct ggaaaaccca ggcttgggca ggaaactctc tgactttgga caggtgagcc      960

acggcagcct gagctgctca gttaggggaa tttgggcctc cagagaaaga gatccgaaga     1020

ctgctggtgc ttcctggttt cataagctca gtaagaagtc tgaattcgtt ggaagctgat     1080

gagaatatcc aggaagtcaa cagacaaatg tcctcaacaa ttgtttctaa gtaggagaac     1140

atctgtcctc ggtggctttc acaggaaaag cttctgacct cttctcttcc tcccacaggg     1200

cagcggagct actaacttca gcctgctgaa gcaggctgga gacgtggagg agaaccctgg     1260

acctatgtcc accgctgtgc tggagaaccc tgggctgggg aggaaactgt cagacttcgg     1320

gcaggagact tcatacattg aggataactg taaccagaat ggcgccatct ctctgatctt     1380

cagcctgaag gaggaagtgg gcgccctggc aaaggtgctg cgcctgtttg aggagaacga     1440

cgtgaatctg acccacatcg agtcccggcc ttctagactg aagaaggacg agtacgagtt     1500

ctttacccac ctggataagc ggtccctgcc agccctgaca aacatcatca agatcctgag     1560

gcacgacatc ggagcaaccg tgcacgagct gtctcgggac aagaagaagg ataccgtgcc     1620

ctggttccct cggacaatcc aggagctgga tagatttgcc aaccagatcc tgtcttacgg     1680

agcagagctg gacgcagatc accctggctt caaggaccca gtgtatcggg cccggagaaa     1740

gcagtttgcc gatatcgcct acaattatag gcacggacag ccaatccctc gcgtggagta     1800

tatggaggag gagaagaaga cctggggcac agtgttcaag accctgaaga gcctgtacaa     1860

gacacacgcc tgctacgagt ataaccacat cttccccctg ctggagaagt attgtggctt     1920

tcacgaggac aatatccctc agctggagga cgtgagccag ttcctgcaga cctgcacagg     1980

ctttaggctg aggccagtgg caggactgct gagctcccgg gacttcctgg gaggactggc     2040

cttcagagtg tttcactgca cccagtacat caggcacggc tccaagccaa tgtatacacc     2100

agagcccgac atctgtcacg agctgctggg ccacgtgccc ctgtttagcg atagatcctt     2160

cgcccagttt tcccaggaga tcggactggc atctctggga gcacctgacg agtacatcga     2220

gaagctggcc accatctatt ggttcacagt ggagtttggc ctgtgcaagc agggcgatag     2280

catcaaggcc tacggagcag gactgctgtc tagcttcggc gagctgcagt attgtctgtc     2340

cgagaagcca aagctgctgc ccctggagct ggagaagacc gccatccaga actacaccgt     2400

gacagagttc cagcccctgt actatgtggc cgagtctttt aacgatgcca aggagaaggt     2460

gagaaatttc gccgccacaa tccctaggcc cttcagcgtg cggtacgacc cttataccca     2520

gaggatcgag gtgctggata atacacagca gctgaagatc ctggctgact caatcaatag     2580

cgaaatcgga atcctgtgct ccgccctgca gaaaatcaaa tgaggtaccg atccagacat     2640

gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt     2700

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca     2760

agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt     2820

tttttaagga tccctgggat gggatgtgga atccttctag atttcttttg taatatttat     2880

aaagtgctct cagcaaggta tcaaaatggc aaaattgtga gtaactatcc tcctttcatt     2940

ttgggaagaa gatgaggcat gaagagaatt cagacagaaa cttactcaga ccaggggagg     3000

cagaaactaa gcagagagga aaatgaccaa gagttagccc tgggcatgga atgtgaaaga     3060

accctaaacg tgacttggaa ataatgccca aggtatattc cattctccgg gatttgttgg     3120

cattttcttg aggtgaagaa ttgcagaata cattctttaa tgtgacctac atatttaccc     3180

atgggaggaa gtctgctcct ggactcttga gattcagtca taaagcccag gccagggaaa     3240

taatgtaagt ctgcaggccc ctgtcatcag taggattagg gagaagagtt ctcagtagaa     3300

aacagggagg ctggagagaa aagaatggtt aatgttaacg ttaatataac tagaaagact     3360

gcagaactta ggactgattt ttatttgaat ccttaaaaaa aaaaatttct tatgaaaata     3420

gtacatggct cttaggagac agaacttatt gtacagagga acagcgtgag agtcagagtg     3480

atcccagaac aggtcctggc tccatcctgc acatagtttt ggtgctgctg gcaatacggt     3540

ccccacaact gtgggaaggg gttaggggca gggatctcat caggaaagca taggggttta     3600

aagttcttta tagagcactt agaagattga gaatccacaa attatattaa taacaaacaa     3660

agtagtgtcg tgttatatag taaatgtgaa tttgcagaca catttaggga aaagttataa     3720

ttaaaaaaat aggctgtata tatacctgca ggtctagata cgtagataag tagcatggcg     3780

ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg     3840

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     3900

cggcctcagt gagcgagcga gcgcgcagag agggagtggc caa                       3943


<210>  56
<211>  3943
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.2 vector correction genome (+ ITRs)

<400>  56
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgct tcaggagcag ttgtgcgaat agctggagaa      240

caccaggctg gatttaaacc cagatcgctc ttacatttgc tctttacctg ctgtgctcag      300

cgttcacgtg ccctctagct gtagttttct gaagtcagcg cacagcaagg cagtgtgctt      360

agaggttaac agaagggaaa acaacaacaa caaaaatcta aatgagaatc ctgactgttt      420

cagctggggg taaggggggc ggattattca tataattgtt ataccagacg gtcgcaggct      480

tagtccaatt gcagagaact cgcttcccag gcttctgaga gtcccggaag tgcctaaacc      540

tgtctaatcg acggggcttg ggtggcccgt cgctccctgg cttcttccct ttacccaggg      600

cgggcagcga agtggtgcct cctgcgtccc ccacaccctc cctcagcccc tcccctccgg      660

cccgtcctgg gcaggtgacc tggagcatcc ggcaggctgc cctggcctcc tgcgtcagga      720

caacgcccac gaggggcgtt actgtgcgga gatgcaccac gcaagagaca ccctttgtaa      780

ctctcttctc ctccctagtg cgaggttaaa accttcagcc ccacgtgctg tttgcaaacc      840

tgcctgtacc tgaggcccta aaaagccaga gacctcactc ccggggagcc accatggcgg      900

cggcggtcct ggaaaaccca ggcttgggca ggaaactctc tgactttgga caggtgagcc      960

acggcagcct gagctgctca gttaggggaa tttgggcctc cagagaaaga gatccgaaga     1020

ctgctggtgc ttcctggttt cataagctca gtaagaagtc tgaattcgtt ggaagctgat     1080

gagaatatcc aggaagtcaa cagacaaatg tcctcaacaa ttgtttctaa gtaggagaac     1140

atctgtcctc ggtggctttc acaggaaaag cttctgacct cttctcttcc tcccacaggg     1200

cagcggagct actaacttca gcctgctgaa gcaggctgga gacgtggagg agaaccctgg     1260

acctatgtcc accgctgtgc tggagaaccc tgggctgggg aggaaactgt cagacttcgg     1320

gcaggagact tcatacattg aggataactg taaccagaat ggcgccatct ctctgatctt     1380

cagcctgaag gaggaagtgg gcgccctggc aaaggtgctg cgcctgtttg aggagaacga     1440

cgtgaatctg acccacatcg agtcccggcc ttctagactg aagaaggacg agtacgagtt     1500

ctttacccac ctggataagc ggtccctgcc agccctgaca aacatcatca agatcctgag     1560

gcacgacatc ggagcaaccg tgcacgagct gtctcgggac aagaagaagg ataccgtgcc     1620

ctggttccct cggacaatcc aggagctgga tagatttgcc aaccagatcc tgtcttacgg     1680

agcagagctg gacgcagatc accctggctt caaggaccca gtgtatcggg cccggagaaa     1740

gcagtttgcc gatatcgcct acaattatag gcacggacag ccaatccctc gcgtggagta     1800

tatggaggag gagaagaaga cctggggcac agtgttcaag accctgaaga gcctgtacaa     1860

gacacacgcc tgctacgagt ataaccacat cttccccctg ctggagaagt attgtggctt     1920

tcacgaggac aatatccctc agctggagga cgtgagccag ttcctgcaga cctgcacagg     1980

ctttaggctg aggccagtgg caggactgct gagctcccgg gacttcctgg gaggactggc     2040

cttcagagtg tttcactgca cccagtacat caggcacggc tccaagccaa tgtatacacc     2100

agagcccgac atctgtcacg agctgctggg ccacgtgccc ctgtttagcg atagatcctt     2160

cgcccagttt tcccaggaga tcggactggc atctctggga gcacctgacg agtacatcga     2220

gaagctggcc accatctatt ggttcacagt ggagtttggc ctgtgcaagc agggcgatag     2280

catcaaggcc tacggagcag gactgctgtc tagcttcggc gagctgcagt attgtctgtc     2340

cgagaagcca aagctgctgc ccctggagct ggagaagacc gccatccaga actacaccgt     2400

gacagagttc cagcccctgt actatgtggc cgagtctttt aacgatgcca aggagaaggt     2460

gagaaatttc gccgccacaa tccctaggcc cttcagcgtg cggtacgacc cttataccca     2520

gaggatcgag gtgctggata atacacagca gctgaagatc ctggctgact caatcaatag     2580

cgaaatcgga atcctgtgct ccgccctgca gaaaatcaaa tgaggtaccg atccagacat     2640

gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt     2700

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca     2760

agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt     2820

tttttaagga tccctgggat gggatgtgga atccttctag atttcttttg taatatttat     2880

aaagtgctct cagcaaggta tcaaaatggc aaaattgtga gtaactatcc tcctttcatt     2940

ttgggaagaa gatgaggcat gaagagaatt cagacagaaa cttactcaga ccaggggagg     3000

cagaaactaa gcagagagga aaatgaccaa gagttagccc tgggcatgga atgtgaaaga     3060

accctaaacg tgacttggaa ataatgccca aggtatattc cattctccgg gatttgttgg     3120

cattttcttg aggtgaagaa ttgcagaata cattctttaa tgtgacctac atatttaccc     3180

atgggaggaa gtctgctcct ggactcttga gattcagtca taaagcccag gccagggaaa     3240

taatgtaagt ctgcaggccc ctgtcatcag taggattagg gagaagagtt ctcagtagaa     3300

aacagggagg ctggagagaa aagaatggtt aatgttaacg ttaatataac tagaaagact     3360

gcagaactta ggactgattt ttatttgaat ccttaaaaaa aaaaatttct tatgaaaata     3420

gtacatggct cttaggagac agaacttatt gtacagagga acagcgtgag agtcagagtg     3480

atcccagaac aggtcctggc tccatcctgc acatagtttt ggtgctgctg gcaatacggt     3540

ccccacaact gtgggaaggg gttaggggca gggatctcat caggaaagca taggggttta     3600

aagttcttta tagagcactt agaagattga gaatccacaa attatattaa taacaaacaa     3660

agtagtgtcg tgttatatag taaatgtgaa tttgcagaca catttaggga aaagttataa     3720

ttaaaaaaat aggctgtata tatacctgca ggtctagata cgtagataag tagcatggcg     3780

ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg     3840

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     3900

cggcctcagt gagcgagcga gcgcgcagag agggagtggc caa                       3943


<210>  57
<211>  3943
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.3 vector correction genome (+ ITRs)

<400>  57
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgct tcaggagcag ttgtgcgaat agctggagaa      240

caccaggctg gatttaaacc cagatcgctc ttacatttgc tctttacctg ctgtgctcag      300

cgttcacgtg ccctctagct gtagttttct gaagtcagcg cacagcaagg cagtgtgctt      360

agaggttaac agaagggaaa acaacaacaa caaaaatcta aatgagaatc ctgactgttt      420

cagctgagag taaggggggc ggattattca tataattgtt ataccagacg gtcgcaggct      480

tagtccaatt gcagagaact cgcttcccag gcttctgaga gtcccggaag tgcctaaacc      540

tgtctaatcg acggggcttg ggtggcccgt cgctccctgg cttcttccct ttacccaggg      600

cgggcagcga agtggtgcct cctgcgtccc ccacaccctc cctcagcccc tcccctccgg      660

cccgtcctgg gcaggtgacc tggagcatcc ggcaggctgc cctggcctcc tgcgtcagga      720

caacgcccac gaggggcgtt actgtgcgga gatgcaccac gcaagagaca ccctttgtaa      780

ctctcttctc ctccctagtg cgaggttaaa accttcagcc ccacgtgctg tttgcaaacc      840

tgcctgtacc tgaggcccta aaaagccaga gacctcactc ccggggagcc agcatgtcca      900

ctgcggtcct ggaaaaccca ggcttgggca ggaaactctc tgactttgga caggtgagcc      960

acggcagcct gagctgctca gttaggggaa tttgggcctc cagagaaaga gatccgaaga     1020

ctgctggtgc ttcctggttt cataagctca gtaagaagtc tgaattcgtt ggaagctgat     1080

gagaatatcc aggaagtcaa cagacaaatg tcctcaacaa ttgtttctaa gtaggagaac     1140

atctgtcctc ggtggctttc acaggaaaag cttctgacct cttctcttcc tcccacaggg     1200

cagcggagct actaacttca gcctgctgaa gcaggctgga gacgtggagg agaaccctgg     1260

acctatgtcc accgctgtgc tggagaaccc tgggctgggg aggaaactgt cagacttcgg     1320

gcaggagact tcatacattg aggataactg taaccagaat ggcgccatct ctctgatctt     1380

cagcctgaag gaggaagtgg gcgccctggc aaaggtgctg cgcctgtttg aggagaacga     1440

cgtgaatctg acccacatcg agtcccggcc ttctagactg aagaaggacg agtacgagtt     1500

ctttacccac ctggataagc ggtccctgcc agccctgaca aacatcatca agatcctgag     1560

gcacgacatc ggagcaaccg tgcacgagct gtctcgggac aagaagaagg ataccgtgcc     1620

ctggttccct cggacaatcc aggagctgga tagatttgcc aaccagatcc tgtcttacgg     1680

agcagagctg gacgcagatc accctggctt caaggaccca gtgtatcggg cccggagaaa     1740

gcagtttgcc gatatcgcct acaattatag gcacggacag ccaatccctc gcgtggagta     1800

tatggaggag gagaagaaga cctggggcac agtgttcaag accctgaaga gcctgtacaa     1860

gacacacgcc tgctacgagt ataaccacat cttccccctg ctggagaagt attgtggctt     1920

tcacgaggac aatatccctc agctggagga cgtgagccag ttcctgcaga cctgcacagg     1980

ctttaggctg aggccagtgg caggactgct gagctcccgg gacttcctgg gaggactggc     2040

cttcagagtg tttcactgca cccagtacat caggcacggc tccaagccaa tgtatacacc     2100

agagcccgac atctgtcacg agctgctggg ccacgtgccc ctgtttagcg atagatcctt     2160

cgcccagttt tcccaggaga tcggactggc atctctggga gcacctgacg agtacatcga     2220

gaagctggcc accatctatt ggttcacagt ggagtttggc ctgtgcaagc agggcgatag     2280

catcaaggcc tacggagcag gactgctgtc tagcttcggc gagctgcagt attgtctgtc     2340

cgagaagcca aagctgctgc ccctggagct ggagaagacc gccatccaga actacaccgt     2400

gacagagttc cagcccctgt actatgtggc cgagtctttt aacgatgcca aggagaaggt     2460

gagaaatttc gccgccacaa tccctaggcc cttcagcgtg cggtacgacc cttataccca     2520

gaggatcgag gtgctggata atacacagca gctgaagatc ctggctgact caatcaatag     2580

cgaaatcgga atcctgtgct ccgccctgca gaaaatcaaa tgaggtaccg atccagacat     2640

gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt     2700

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca     2760

agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt     2820

tttttaagga tccctgggat gggatgtgga atccttctag atttcttttg taatatttat     2880

aaagtgctct cagcaaggta tcaaaatggc aaaattgtga gtaactatcc tcctttcatt     2940

ttgggaagaa gatgaggcat gaagagaatt cagacagaaa cttactcaga ccaggggagg     3000

cagaaactaa gcagagagga aaatgaccaa gagttagccc tgggcatgga atgtgaaaga     3060

accctaaacg tgacttggaa ataatgccca aggtatattc cattctccgg gatttgttgg     3120

cattttcttg aggtgaagaa ttgcagaata cattctttaa tgtgacctac atatttaccc     3180

atgggaggaa gtctgctcct ggactcttga gattcagtca taaagcccag gccagggaaa     3240

taatgtaagt ctgcaggccc ctgtcatcag taggattagg gagaagagtt ctcagtagaa     3300

aacagggagg ctggagagaa aagaatggtt aatgttaacg ttaatataac tagaaagact     3360

gcagaactta ggactgattt ttatttgaat ccttaaaaaa aaaaatttct tatgaaaata     3420

gtacatggct cttaggagac agaacttatt gtacagagga acagcgtgag agtcagagtg     3480

atcccagaac aggtcctggc tccatcctgc acatagtttt ggtgctgctg gcaatacggt     3540

ccccacaact gtgggaaggg gttaggggca gggatctcat caggaaagca taggggttta     3600

aagttcttta tagagcactt agaagattga gaatccacaa attatattaa taacaaacaa     3660

agtagtgtcg tgttatatag taaatgtgaa tttgcagaca catttaggga aaagttataa     3720

ttaaaaaaat aggctgtata tatacctgca ggtctagata cgtagataag tagcatggcg     3780

ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg     3840

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     3900

cggcctcagt gagcgagcga gcgcgcagag agggagtggc caa                       3943


<210>  58
<211>  3943
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.4 vector correction genome (+ ITRs)

<400>  58
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgct tcaggagcag ttgtgcgaat agctggagaa      240

caccaggctg gatttaaacc cagatcgctc ttacatttgc tctttacctg ctgtgctcag      300

cgttcacgtg ccctctagct gtagttttct gaagtcagcg cacagcaagg cagtgtgctt      360

agaggttaac agaagggaaa acaacaacaa caaaaatcta aatgagaatc ctgactgttt      420

cagctggggg taaggggggc ggattattca tataattgtt ataccagacg gtcgcaggct      480

tagtccaatt gcagagaact cgcttcccag gcttctgaga gtcccggaag tgcctaaacc      540

tgtctaatcg acggggcttg ggtggcccgt cgctccctgg cttcttccct ttacccaggg      600

cgggcagcga agtggtgcct cctgcgtccc ccacaccctc cctcagcccc tcccctccgg      660

cccgtcctgg gcaggtgacc tggagcatcc ggcaggctgc cctggcctcc tgagtcagga      720

caacgcccac gaggggcgtt actgtgcgga gatgcaccac gcaagagaca ccctttgtaa      780

ctctcttctc ctccctagtg cgaggttaaa accttcagcc ccacgtgctg tttgcaaacc      840

tgcctgtacc tgaggcccta aaaagccaga gacctcactc ccggggagcc agcatgtcca      900

ctgcggtcct ggaaaaccca ggcttgggca ggaaactctc tgactttgga caggtgagcc      960

acggcagcct gagctgctca gttaggggaa tttgggcctc cagagaaaga gatccgaaga     1020

ctgctggtgc ttcctggttt cataagctca gtaagaagtc tgaattcgtt ggaagctgat     1080

gagaatatcc aggaagtcaa cagacaaatg tcctcaacaa ttgtttctaa gtaggagaac     1140

atctgtcctc ggtggctttc acaggaaaag cttctgacct cttctcttcc tcccacaggg     1200

cagcggagct actaacttca gcctgctgaa gcaggctgga gacgtggagg agaaccctgg     1260

acctatgtcc accgctgtgc tggagaaccc tgggctgggg aggaaactgt cagacttcgg     1320

gcaggagact tcatacattg aggataactg taaccagaat ggcgccatct ctctgatctt     1380

cagcctgaag gaggaagtgg gcgccctggc aaaggtgctg cgcctgtttg aggagaacga     1440

cgtgaatctg acccacatcg agtcccggcc ttctagactg aagaaggacg agtacgagtt     1500

ctttacccac ctggataagc ggtccctgcc agccctgaca aacatcatca agatcctgag     1560

gcacgacatc ggagcaaccg tgcacgagct gtctcgggac aagaagaagg ataccgtgcc     1620

ctggttccct cggacaatcc aggagctgga tagatttgcc aaccagatcc tgtcttacgg     1680

agcagagctg gacgcagatc accctggctt caaggaccca gtgtatcggg cccggagaaa     1740

gcagtttgcc gatatcgcct acaattatag gcacggacag ccaatccctc gcgtggagta     1800

tatggaggag gagaagaaga cctggggcac agtgttcaag accctgaaga gcctgtacaa     1860

gacacacgcc tgctacgagt ataaccacat cttccccctg ctggagaagt attgtggctt     1920

tcacgaggac aatatccctc agctggagga cgtgagccag ttcctgcaga cctgcacagg     1980

ctttaggctg aggccagtgg caggactgct gagctcccgg gacttcctgg gaggactggc     2040

cttcagagtg tttcactgca cccagtacat caggcacggc tccaagccaa tgtatacacc     2100

agagcccgac atctgtcacg agctgctggg ccacgtgccc ctgtttagcg atagatcctt     2160

cgcccagttt tcccaggaga tcggactggc atctctggga gcacctgacg agtacatcga     2220

gaagctggcc accatctatt ggttcacagt ggagtttggc ctgtgcaagc agggcgatag     2280

catcaaggcc tacggagcag gactgctgtc tagcttcggc gagctgcagt attgtctgtc     2340

cgagaagcca aagctgctgc ccctggagct ggagaagacc gccatccaga actacaccgt     2400

gacagagttc cagcccctgt actatgtggc cgagtctttt aacgatgcca aggagaaggt     2460

gagaaatttc gccgccacaa tccctaggcc cttcagcgtg cggtacgacc cttataccca     2520

gaggatcgag gtgctggata atacacagca gctgaagatc ctggctgact caatcaatag     2580

cgaaatcgga atcctgtgct ccgccctgca gaaaatcaaa tgaggtaccg atccagacat     2640

gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt     2700

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca     2760

agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt     2820

tttttaagga tccctgggat gggatgtgga atccttctag atttcttttg taatatttat     2880

aaagtgctct cagcaaggta tcaaaatggc aaaattgtga gtaactatcc tcctttcatt     2940

ttgggaagaa gatgaggcat gaagagaatt cagacagaaa cttactcaga ccaggggagg     3000

cagaaactaa gcagagagga aaatgaccaa gagttagccc tgggcatgga atgtgaaaga     3060

accctaaacg tgacttggaa ataatgccca aggtatattc cattctccgg gatttgttgg     3120

cattttcttg aggtgaagaa ttgcagaata cattctttaa tgtgacctac atatttaccc     3180

atgggaggaa gtctgctcct ggactcttga gattcagtca taaagcccag gccagggaaa     3240

taatgtaagt ctgcaggccc ctgtcatcag taggattagg gagaagagtt ctcagtagaa     3300

aacagggagg ctggagagaa aagaatggtt aatgttaacg ttaatataac tagaaagact     3360

gcagaactta ggactgattt ttatttgaat ccttaaaaaa aaaaatttct tatgaaaata     3420

gtacatggct cttaggagac agaacttatt gtacagagga acagcgtgag agtcagagtg     3480

atcccagaac aggtcctggc tccatcctgc acatagtttt ggtgctgctg gcaatacggt     3540

ccccacaact gtgggaaggg gttaggggca gggatctcat caggaaagca taggggttta     3600

aagttcttta tagagcactt agaagattga gaatccacaa attatattaa taacaaacaa     3660

agtagtgtcg tgttatatag taaatgtgaa tttgcagaca catttaggga aaagttataa     3720

ttaaaaaaat aggctgtata tatacctgca ggtctagata cgtagataag tagcatggcg     3780

ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg     3840

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     3900

cggcctcagt gagcgagcga gcgcgcagag agggagtggc caa                       3943


<210>  59
<211>  3943
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.5 vector correction genome (+ ITRs)

<400>  59
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgct tcaggagcag ttgtgcgaat agctggagaa      240

caccaggctg gatttaaacc cagatcgctc ttacatttgc tctttacctg ctgtgctcag      300

cgttcacgtg ccctctagct gtagttttct gaagtcagcg cacagcaagg cagtgtgctt      360

agaggttaac agaagggaaa acaacaacaa caaaaatcta aatgagaatc ctgactgttt      420

cagctggggg taaggggggc ggattattca tataattgtt ataccagacg gtcgcaggct      480

tagtccaatt gcagagaact cgcttcccag gcttctgaga gtcccggaag tgcctaaacc      540

tgtctaatcg acggggcttg ggtggcccgt cgctccctgg cttcttccct ttacccaggg      600

cgggcagcga agtggtgcct cctgcgtccc ccacaccctc cctcagcccc tcccctccgg      660

cccgtcctgg gcaggtgacg tcaagcatcc ggcaggctgc cctggcctcc tgagtcagga      720

caacgcccac gaggggcgtt actgtgcgga gatgcaccac gcaagagaca ccctttgtaa      780

ctctcttctc ctccctagtg cgaggttaaa accttcagcc ccacgtgctg tttgcaaacc      840

tgcctgtacc tgaggcccta aaaagccaga gacctcactc ccggggagcc agcatgtcca      900

ctgcggtcct ggaaaaccca ggcttgggca ggaaactctc tgactttgga caggtgagcc      960

acggcagcct gagctgctca gttaggggaa tttgggcctc cagagaaaga gatccgaaga     1020

ctgctggtgc ttcctggttt cataagctca gtaagaagtc tgaattcgtt ggaagctgat     1080

gagaatatcc aggaagtcaa cagacaaatg tcctcaacaa ttgtttctaa gtaggagaac     1140

atctgtcctc ggtggctttc acaggaaaag cttctgacct cttctcttcc tcccacaggg     1200

cagcggagct actaacttca gcctgctgaa gcaggctgga gacgtggagg agaaccctgg     1260

acctatgtcc accgctgtgc tggagaaccc tgggctgggg aggaaactgt cagacttcgg     1320

gcaggagact tcatacattg aggataactg taaccagaat ggcgccatct ctctgatctt     1380

cagcctgaag gaggaagtgg gcgccctggc aaaggtgctg cgcctgtttg aggagaacga     1440

cgtgaatctg acccacatcg agtcccggcc ttctagactg aagaaggacg agtacgagtt     1500

ctttacccac ctggataagc ggtccctgcc agccctgaca aacatcatca agatcctgag     1560

gcacgacatc ggagcaaccg tgcacgagct gtctcgggac aagaagaagg ataccgtgcc     1620

ctggttccct cggacaatcc aggagctgga tagatttgcc aaccagatcc tgtcttacgg     1680

agcagagctg gacgcagatc accctggctt caaggaccca gtgtatcggg cccggagaaa     1740

gcagtttgcc gatatcgcct acaattatag gcacggacag ccaatccctc gcgtggagta     1800

tatggaggag gagaagaaga cctggggcac agtgttcaag accctgaaga gcctgtacaa     1860

gacacacgcc tgctacgagt ataaccacat cttccccctg ctggagaagt attgtggctt     1920

tcacgaggac aatatccctc agctggagga cgtgagccag ttcctgcaga cctgcacagg     1980

ctttaggctg aggccagtgg caggactgct gagctcccgg gacttcctgg gaggactggc     2040

cttcagagtg tttcactgca cccagtacat caggcacggc tccaagccaa tgtatacacc     2100

agagcccgac atctgtcacg agctgctggg ccacgtgccc ctgtttagcg atagatcctt     2160

cgcccagttt tcccaggaga tcggactggc atctctggga gcacctgacg agtacatcga     2220

gaagctggcc accatctatt ggttcacagt ggagtttggc ctgtgcaagc agggcgatag     2280

catcaaggcc tacggagcag gactgctgtc tagcttcggc gagctgcagt attgtctgtc     2340

cgagaagcca aagctgctgc ccctggagct ggagaagacc gccatccaga actacaccgt     2400

gacagagttc cagcccctgt actatgtggc cgagtctttt aacgatgcca aggagaaggt     2460

gagaaatttc gccgccacaa tccctaggcc cttcagcgtg cggtacgacc cttataccca     2520

gaggatcgag gtgctggata atacacagca gctgaagatc ctggctgact caatcaatag     2580

cgaaatcgga atcctgtgct ccgccctgca gaaaatcaaa tgaggtaccg atccagacat     2640

gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt     2700

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca     2760

agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt     2820

tttttaagga tccctgggat gggatgtgga atccttctag atttcttttg taatatttat     2880

aaagtgctct cagcaaggta tcaaaatggc aaaattgtga gtaactatcc tcctttcatt     2940

ttgggaagaa gatgaggcat gaagagaatt cagacagaaa cttactcaga ccaggggagg     3000

cagaaactaa gcagagagga aaatgaccaa gagttagccc tgggcatgga atgtgaaaga     3060

accctaaacg tgacttggaa ataatgccca aggtatattc cattctccgg gatttgttgg     3120

cattttcttg aggtgaagaa ttgcagaata cattctttaa tgtgacctac atatttaccc     3180

atgggaggaa gtctgctcct ggactcttga gattcagtca taaagcccag gccagggaaa     3240

taatgtaagt ctgcaggccc ctgtcatcag taggattagg gagaagagtt ctcagtagaa     3300

aacagggagg ctggagagaa aagaatggtt aatgttaacg ttaatataac tagaaagact     3360

gcagaactta ggactgattt ttatttgaat ccttaaaaaa aaaaatttct tatgaaaata     3420

gtacatggct cttaggagac agaacttatt gtacagagga acagcgtgag agtcagagtg     3480

atcccagaac aggtcctggc tccatcctgc acatagtttt ggtgctgctg gcaatacggt     3540

ccccacaact gtgggaaggg gttaggggca gggatctcat caggaaagca taggggttta     3600

aagttcttta tagagcactt agaagattga gaatccacaa attatattaa taacaaacaa     3660

agtagtgtcg tgttatatag taaatgtgaa tttgcagaca catttaggga aaagttataa     3720

ttaaaaaaat aggctgtata tatacctgca ggtctagata cgtagataag tagcatggcg     3780

ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg     3840

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     3900

cggcctcagt gagcgagcga gcgcgcagag agggagtggc caa                       3943


<210>  60
<211>  3943
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.6 vector correction genome (+ ITRs)

<400>  60
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgct tcaggagcag ttgtgcgaat agctggagaa      240

caccaggctg gatttaaacc cagatcgctc ttacatttgc tctttacctg ctgtgctcag      300

cgttcacgtg ccctctagct gtagttttct gaagtcagcg cacagcaagg cagtgtgctt      360

agaggttaac agaagggaaa acaacaacaa caaaaatcta aatgagaatc ctgactgttt      420

cagctggggg taaggggggc ggattattca tataattgtt ataccagacg gtcgcaggct      480

tagtccaatt gcagagaact cgcttcccag gcttctgaga gtcccggaag tgcctaaacc      540

tgtctaatcg acggggcttg ggtggcccgt cgctccctgg cttcttccct ttacccaggg      600

cgggcagcga agtggtgcct cctgcgtccc ccacaccctc cctcagcccc tcccctccgg      660

cccgtcctgg gcaggtgacc tggagcatcc ggcaggctgc cctggcctcc tgcgtcagga      720

caacgcccac gaggggcgtt actgtgcgga gatgcaccac gcaagagaca ccctttgtaa      780

ctctcttctc ctccctagtg cgaggttaaa accttcagcc ccacgtgctg tttgcaaacc      840

tgcctgtacc tgaggcccta aaaagccaga gacctcactc ccggggagcc agcatgtcca      900

ctgcggtcct ggaaaaccca ggcttgggca ggaaactctc tgactttgga caggtgagcc      960

acggcagcct gagctgctca gttaggggaa tttgggcctc cagagaaaga gatccgaaga     1020

ctgctggtgc ttcctggttt cataagctca gtaagaagtc tgaattcgtt ggaagctgat     1080

gagaatgtcc aggaagtcaa cagacaaatg tcctcaacaa ttgtttctaa gtaggagaac     1140

atctgtcctc ggtggctttc acaggaaaag cttctgacct cttctcttcc tcccacaggg     1200

cagcggagct actaacttca gcctgctgaa gcaggctgga gacgtggagg agaaccctgg     1260

acctatgtcc accgctgtgc tggagaaccc tgggctgggg aggaaactgt cagacttcgg     1320

gcaggagact tcatacattg aggataactg taaccagaat ggcgccatct ctctgatctt     1380

cagcctgaag gaggaagtgg gcgccctggc aaaggtgctg cgcctgtttg aggagaacga     1440

cgtgaatctg acccacatcg agtcccggcc ttctagactg aagaaggacg agtacgagtt     1500

ctttacccac ctggataagc ggtccctgcc agccctgaca aacatcatca agatcctgag     1560

gcacgacatc ggagcaaccg tgcacgagct gtctcgggac aagaagaagg ataccgtgcc     1620

ctggttccct cggacaatcc aggagctgga tagatttgcc aaccagatcc tgtcttacgg     1680

agcagagctg gacgcagatc accctggctt caaggaccca gtgtatcggg cccggagaaa     1740

gcagtttgcc gatatcgcct acaattatag gcacggacag ccaatccctc gcgtggagta     1800

tatggaggag gagaagaaga cctggggcac agtgttcaag accctgaaga gcctgtacaa     1860

gacacacgcc tgctacgagt ataaccacat cttccccctg ctggagaagt attgtggctt     1920

tcacgaggac aatatccctc agctggagga cgtgagccag ttcctgcaga cctgcacagg     1980

ctttaggctg aggccagtgg caggactgct gagctcccgg gacttcctgg gaggactggc     2040

cttcagagtg tttcactgca cccagtacat caggcacggc tccaagccaa tgtatacacc     2100

agagcccgac atctgtcacg agctgctggg ccacgtgccc ctgtttagcg atagatcctt     2160

cgcccagttt tcccaggaga tcggactggc atctctggga gcacctgacg agtacatcga     2220

gaagctggcc accatctatt ggttcacagt ggagtttggc ctgtgcaagc agggcgatag     2280

catcaaggcc tacggagcag gactgctgtc tagcttcggc gagctgcagt attgtctgtc     2340

cgagaagcca aagctgctgc ccctggagct ggagaagacc gccatccaga actacaccgt     2400

gacagagttc cagcccctgt actatgtggc cgagtctttt aacgatgcca aggagaaggt     2460

gagaaatttc gccgccacaa tccctaggcc cttcagcgtg cggtacgacc cttataccca     2520

gaggatcgag gtgctggata atacacagca gctgaagatc ctggctgact caatcaatag     2580

cgaaatcgga atcctgtgct ccgccctgca gaaaatcaaa tgaggtaccg atccagacat     2640

gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt     2700

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca     2760

agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt     2820

tttttaagga tccctgggat gggatgtgga atccttctag atttcttttg taatatttat     2880

aaagtgctct cagcaaggta tcaaaatggc aaaattgtga gtaactatcc tcctttcatt     2940

ttgggaagaa gatgaggcat gaagagaatt cagacagaaa cttactcaga ccaggggagg     3000

cagaaactaa gcagagagga aaatgaccaa gagttagccc tgggcatgga atgtgaaaga     3060

accctaaacg tgacttggaa ataatgccca aggtatattc cattctccgg gatttgttgg     3120

cattttcttg aggtgaagaa ttgcagaata cattctttaa tgtgacctac atatttaccc     3180

atgggaggaa gtctgctcct ggactcttga gattcagtca taaagcccag gccagggaaa     3240

taatgtaagt ctgcaggccc ctgtcatcag taggattagg gagaagagtt ctcagtagaa     3300

aacagggagg ctggagagaa aagaatggtt aatgttaacg ttaatataac tagaaagact     3360

gcagaactta ggactgattt ttatttgaat ccttaaaaaa aaaaatttct tatgaaaata     3420

gtacatggct cttaggagac agaacttatt gtacagagga acagcgtgag agtcagagtg     3480

atcccagaac aggtcctggc tccatcctgc acatagtttt ggtgctgctg gcaatacggt     3540

ccccacaact gtgggaaggg gttaggggca gggatctcat caggaaagca taggggttta     3600

aagttcttta tagagcactt agaagattga gaatccacaa attatattaa taacaaacaa     3660

agtagtgtcg tgttatatag taaatgtgaa tttgcagaca catttaggga aaagttataa     3720

ttaaaaaaat aggctgtata tatacctgca ggtctagata cgtagataag tagcatggcg     3780

ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg     3840

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     3900

cggcctcagt gagcgagcga gcgcgcagag agggagtggc caa                       3943


<210>  61
<211>  3943
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.7 vector correction genome (+ ITRs)

<400>  61
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgct tcaggagcag ttgtgcgaat agctggagaa      240

caccaggctg gatttaaacc cagatcgctc ttacatttgc tctttacctg ctgtgctcag      300

cgttcacgtg ccctctagct gtagttttct gaagtcagcg cacagcaagg cagtgtgctt      360

agaggttaac agaagggaaa acaacaacaa caaaaatcta aatgagaatc ctgactgttt      420

cagctggggg taaggggggc ggattattca tataattgtt ccaccagacg gtcgcaggct      480

tagtccaatt gcagagaact cgcttcccag gcttctgaga gtcccggaag tgcctaaacc      540

tgtctaatcg acggggcttg ggtggcccgt cgctccctgg cttcttccct ttacccaggg      600

cgggcagcga agtggtgcct cctgcgtccc ccacaccctc cctcagcccc tcccctccgg      660

cccgtcctgg gcaggtgacc tggagcatcc ggcaggctgc cctggcctcc tgcgtcagga      720

caacgcccac gaggggcgtt actgtgcgga gatgcaccac gcaagagaca ccctttgtaa      780

ctctcttctc ctccctagtg cgaggttaaa accttcagcc ccacgtgctg tttgcaaacc      840

tgcctgtacc tgaggcccta aaaagccaga gacctcactc ccggggagcc agcatgtcca      900

ctgcggtcct ggaaaaccca ggcttgggca ggaaactctc tgactttgga caggtgagcc      960

acggcagcct gagctgctca gttaggggaa tttgggcctc cagagaaaga gatccgaaga     1020

ctgctggtgc ttcctggttt cataagctca gtaagaagtc tgaattcgtt ggaagctgat     1080

gagaatatcc aggaagtcaa cagacaaatg tcctcaacaa ttgtttctaa gtaggagaac     1140

atctgtcctc ggtggctttc acaggaaaag cttctgacct cttctcttcc tcccacaggg     1200

cagcggagct actaacttca gcctgctgaa gcaggctgga gacgtggagg agaaccctgg     1260

acctatgtcc accgctgtgc tggagaaccc tgggctgggg aggaaactgt cagacttcgg     1320

gcaggagact tcatacattg aggataactg taaccagaat ggcgccatct ctctgatctt     1380

cagcctgaag gaggaagtgg gcgccctggc aaaggtgctg cgcctgtttg aggagaacga     1440

cgtgaatctg acccacatcg agtcccggcc ttctagactg aagaaggacg agtacgagtt     1500

ctttacccac ctggataagc ggtccctgcc agccctgaca aacatcatca agatcctgag     1560

gcacgacatc ggagcaaccg tgcacgagct gtctcgggac aagaagaagg ataccgtgcc     1620

ctggttccct cggacaatcc aggagctgga tagatttgcc aaccagatcc tgtcttacgg     1680

agcagagctg gacgcagatc accctggctt caaggaccca gtgtatcggg cccggagaaa     1740

gcagtttgcc gatatcgcct acaattatag gcacggacag ccaatccctc gcgtggagta     1800

tatggaggag gagaagaaga cctggggcac agtgttcaag accctgaaga gcctgtacaa     1860

gacacacgcc tgctacgagt ataaccacat cttccccctg ctggagaagt attgtggctt     1920

tcacgaggac aatatccctc agctggagga cgtgagccag ttcctgcaga cctgcacagg     1980

ctttaggctg aggccagtgg caggactgct gagctcccgg gacttcctgg gaggactggc     2040

cttcagagtg tttcactgca cccagtacat caggcacggc tccaagccaa tgtatacacc     2100

agagcccgac atctgtcacg agctgctggg ccacgtgccc ctgtttagcg atagatcctt     2160

cgcccagttt tcccaggaga tcggactggc atctctggga gcacctgacg agtacatcga     2220

gaagctggcc accatctatt ggttcacagt ggagtttggc ctgtgcaagc agggcgatag     2280

catcaaggcc tacggagcag gactgctgtc tagcttcggc gagctgcagt attgtctgtc     2340

cgagaagcca aagctgctgc ccctggagct ggagaagacc gccatccaga actacaccgt     2400

gacagagttc cagcccctgt actatgtggc cgagtctttt aacgatgcca aggagaaggt     2460

gagaaatttc gccgccacaa tccctaggcc cttcagcgtg cggtacgacc cttataccca     2520

gaggatcgag gtgctggata atacacagca gctgaagatc ctggctgact caatcaatag     2580

cgaaatcgga atcctgtgct ccgccctgca gaaaatcaaa tgaggtaccg atccagacat     2640

gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt     2700

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca     2760

agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt     2820

tttttaagga tccctgggat gggatgtgga atccttctag atttcttttg taatatttat     2880

aaagtgctct cagcaaggta tcaaaatggc aaaattgtga gtaactatcc tcctttcatt     2940

ttgggaagaa gatgaggcat gaagagaatt cagacagaaa cttactcaga ccaggggagg     3000

cagaaactaa gcagagagga aaatgaccaa gagttagccc tgggcatgga atgtgaaaga     3060

accctaaacg tgacttggaa ataatgccca aggtatattc cattctccgg gatttgttgg     3120

cattttcttg aggtgaagaa ttgcagaata cattctttaa tgtgacctac atatttaccc     3180

atgggaggaa gtctgctcct ggactcttga gattcagtca taaagcccag gccagggaaa     3240

taatgtaagt ctgcaggccc ctgtcatcag taggattagg gagaagagtt ctcagtagaa     3300

aacagggagg ctggagagaa aagaatggtt aatgttaacg ttaatataac tagaaagact     3360

gcagaactta ggactgattt ttatttgaat ccttaaaaaa aaaaatttct tatgaaaata     3420

gtacatggct cttaggagac agaacttatt gtacagagga acagcgtgag agtcagagtg     3480

atcccagaac aggtcctggc tccatcctgc acatagtttt ggtgctgctg gcaatacggt     3540

ccccacaact gtgggaaggg gttaggggca gggatctcat caggaaagca taggggttta     3600

aagttcttta tagagcactt agaagattga gaatccacaa attatattaa taacaaacaa     3660

agtagtgtcg tgttatatag taaatgtgaa tttgcagaca catttaggga aaagttataa     3720

ttaaaaaaat aggctgtata tatacctgca ggtctagata cgtagataag tagcatggcg     3780

ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg     3840

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     3900

cggcctcagt gagcgagcga gcgcgcagag agggagtggc caa                       3943


<210>  62
<211>  3951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.8 vector correction genome (+ ITRs)

<400>  62
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgct tcaggagcag ttgtgcgaat agctggagaa      240

caccaggctg gatttaaacc cagatcgctc ttacatttgc tctttacctg ctgtgctcag      300

cgttcacgtg ccctctagct gtagttttct gaagtcagcg cacagcaagg cagtgtgctt      360

agaggttaac agaagggaaa acaacaacaa caaaaatcta aatgagaatc ctgactgttt      420

cagctggggg taaggggggc ggattattca tataattgtt ccaccagacg gtcgcaggct      480

tagtccaatt gcagagaaca cgctgttctt cgccccaggc ttctgagagt cccggaagtg      540

cctaaacctg tctaatcgac ggggcttggg tggcccgtcg ctccctggct tcttcccttt      600

acccagggcg ggcagcgaag tggtgcctcc tgcgtccccc acaccctccc tcagcccctc      660

ccctccggcc cgtcctgggc aggtgacctg gagcatccgg caggctgccc tggcctcctg      720

cgtcaggaca acgcccacga ggggcgttac tgtgcggaga tgcaccacgc aagagacacc      780

ctttgtaact ctcttctcct ccctagtgcg aggttaaaac cttcagcccc acgtgctgtt      840

tgcaaacctg cctgtacctg aggccctaaa aagccagaga cctcactccc ggggagccag      900

catgtccact gcggtcctgg aaaacccagg cttgggcagg aaactctctg actttggaca      960

ggtgagccac ggcagcctga gctgctcagt taggggaatt tgggcctcca gagaaagaga     1020

tccgaagact gctggtgctt cctggtttca taagctcagt aagaagtctg aattcgttgg     1080

aagctgatga gaatatccag gaagtcaaca gacaaatgtc ctcaacaatt gtttctaagt     1140

aggagaacat ctgtcctcgg tggctttcac aggaaaagct tctgacctct tctcttcctc     1200

ccacagggca gcggagctac taacttcagc ctgctgaagc aggctggaga cgtggaggag     1260

aaccctggac ctatgtccac cgctgtgctg gagaaccctg ggctggggag gaaactgtca     1320

gacttcgggc aggagacttc atacattgag gataactgta accagaatgg cgccatctct     1380

ctgatcttca gcctgaagga ggaagtgggc gccctggcaa aggtgctgcg cctgtttgag     1440

gagaacgacg tgaatctgac ccacatcgag tcccggcctt ctagactgaa gaaggacgag     1500

tacgagttct ttacccacct ggataagcgg tccctgccag ccctgacaaa catcatcaag     1560

atcctgaggc acgacatcgg agcaaccgtg cacgagctgt ctcgggacaa gaagaaggat     1620

accgtgccct ggttccctcg gacaatccag gagctggata gatttgccaa ccagatcctg     1680

tcttacggag cagagctgga cgcagatcac cctggcttca aggacccagt gtatcgggcc     1740

cggagaaagc agtttgccga tatcgcctac aattataggc acggacagcc aatccctcgc     1800

gtggagtata tggaggagga gaagaagacc tggggcacag tgttcaagac cctgaagagc     1860

ctgtacaaga cacacgcctg ctacgagtat aaccacatct tccccctgct ggagaagtat     1920

tgtggctttc acgaggacaa tatccctcag ctggaggacg tgagccagtt cctgcagacc     1980

tgcacaggct ttaggctgag gccagtggca ggactgctga gctcccggga cttcctggga     2040

ggactggcct tcagagtgtt tcactgcacc cagtacatca ggcacggctc caagccaatg     2100

tatacaccag agcccgacat ctgtcacgag ctgctgggcc acgtgcccct gtttagcgat     2160

agatccttcg cccagttttc ccaggagatc ggactggcat ctctgggagc acctgacgag     2220

tacatcgaga agctggccac catctattgg ttcacagtgg agtttggcct gtgcaagcag     2280

ggcgatagca tcaaggccta cggagcagga ctgctgtcta gcttcggcga gctgcagtat     2340

tgtctgtccg agaagccaaa gctgctgccc ctggagctgg agaagaccgc catccagaac     2400

tacaccgtga cagagttcca gcccctgtac tatgtggccg agtcttttaa cgatgccaag     2460

gagaaggtga gaaatttcgc cgccacaatc cctaggccct tcagcgtgcg gtacgaccct     2520

tatacccaga ggatcgaggt gctggataat acacagcagc tgaagatcct ggctgactca     2580

atcaatagcg aaatcggaat cctgtgctcc gccctgcaga aaatcaaatg aggtaccgat     2640

ccagacatga taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa     2700

aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc     2760

aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca gggggaggtg     2820

tgggaggttt tttaaggatc cctgggatgg gatgtggaat ccttctagat ttcttttgta     2880

atatttataa agtgctctca gcaaggtatc aaaatggcaa aattgtgagt aactatcctc     2940

ctttcatttt gggaagaaga tgaggcatga agagaattca gacagaaact tactcagacc     3000

aggggaggca gaaactaagc agagaggaaa atgaccaaga gttagccctg ggcatggaat     3060

gtgaaagaac cctaaacgtg acttggaaat aatgcccaag gtatattcca ttctccggga     3120

tttgttggca ttttcttgag gtgaagaatt gcagaataca ttctttaatg tgacctacat     3180

atttacccat gggaggaagt ctgctcctgg actcttgaga ttcagtcata aagcccaggc     3240

cagggaaata atgtaagtct gcaggcccct gtcatcagta ggattaggga gaagagttct     3300

cagtagaaaa cagggaggct ggagagaaaa gaatggttaa tgttaacgtt aatataacta     3360

gaaagactgc agaacttagg actgattttt atttgaatcc ttaaaaaaaa aaatttctta     3420

tgaaaatagt acatggctct taggagacag aacttattgt acagaggaac agcgtgagag     3480

tcagagtgat cccagaacag gtcctggctc catcctgcac atagttttgg tgctgctggc     3540

aatacggtcc ccacaactgt gggaaggggt taggggcagg gatctcatca ggaaagcata     3600

ggggtttaaa gttctttata gagcacttag aagattgaga atccacaaat tatattaata     3660

acaaacaaag tagtgtcgtg ttatatagta aatgtgaatt tgcagacaca tttagggaaa     3720

agttataatt aaaaaaatag gctgtatata tacctgcagg tctagatacg tagataagta     3780

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     3840

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt     3900

tgcccgggcg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca a              3951


<210>  63
<211>  3943
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32.9 vector correction genome (+ ITRs)

<400>  63
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgct tcaggagcag ttgtgcgaat agctggagaa      240

caccaggctg gatttaaacc cagatcgctc ttacatttgc tctttacctg ctgtgctcag      300

cgttcacgtg ccctctagct gtagttttct gaagtcagcg cacagcaagg cagtgtgctt      360

agaggttaac agaagggaaa acaacaacaa caaaaatcta aatgagaatc ctgactgttt      420

cagctgagag taaggggggc ggattattca tataattgtt ataccagacg gtcgcaggct      480

tagtccaatt gcagagaact cgcttcccag gcttctgaga gtcccggaag tgcctaaacc      540

tgtctaatcg acagagcttg ggtggcccgt cgctccctgg cttcttccct ttacccaggg      600

cgggcagcga agtggtgcct cctgcgtccc ccacaccctc cctcagcccc tcccctccgg      660

cccgtcctag gcaggtgacc tgaagcatcc agcaggctgc cctggcctcc tgcgtcagga      720

caacgcccac gaggggcgtt actgtgcgga gatgcaccac gcaagagaca ccctttgtaa      780

ctctcttctc ctccctagtg cgaggttaaa accttcagcc ccacgtgctg tttgcaaacc      840

tgcctgtacc tgaggcccta aaaagccaga gacctcactc ccggggagcc agcatgtcca      900

ctgcggtcct ggaaaaccca ggcttgggca ggaaactctc tgactttgga caggtgagcc      960

acggcagcct gagctgctca gttaggggaa tttgggcctc cagagaaaga gatccgaaga     1020

ctgctggtgc ttcctggttt cataagctca gtaagaagtc tgaattcgtt ggaagctgat     1080

gagaatatcc aggaagtcaa cagacaaatg tcctcaacaa ttgtttctaa gtaggagaac     1140

atctgtcctc ggtggctttc acaggaaaag cttctgacct cttctcttcc tcccacaggg     1200

cagcggagct actaacttca gcctgctgaa gcaggctgga gacgtggagg agaaccctgg     1260

acctatgtcc accgctgtgc tggagaaccc tgggctgggg aggaaactgt cagacttcgg     1320

gcaggagact tcatacattg aggataactg taaccagaat ggcgccatct ctctgatctt     1380

cagcctgaag gaggaagtgg gcgccctggc aaaggtgctg cgcctgtttg aggagaacga     1440

cgtgaatctg acccacatcg agtcccggcc ttctagactg aagaaggacg agtacgagtt     1500

ctttacccac ctggataagc ggtccctgcc agccctgaca aacatcatca agatcctgag     1560

gcacgacatc ggagcaaccg tgcacgagct gtctcgggac aagaagaagg ataccgtgcc     1620

ctggttccct cggacaatcc aggagctgga tagatttgcc aaccagatcc tgtcttacgg     1680

agcagagctg gacgcagatc accctggctt caaggaccca gtgtatcggg cccggagaaa     1740

gcagtttgcc gatatcgcct acaattatag gcacggacag ccaatccctc gcgtggagta     1800

tatggaggag gagaagaaga cctggggcac agtgttcaag accctgaaga gcctgtacaa     1860

gacacacgcc tgctacgagt ataaccacat cttccccctg ctggagaagt attgtggctt     1920

tcacgaggac aatatccctc agctggagga cgtgagccag ttcctgcaga cctgcacagg     1980

ctttaggctg aggccagtgg caggactgct gagctcccgg gacttcctgg gaggactggc     2040

cttcagagtg tttcactgca cccagtacat caggcacggc tccaagccaa tgtatacacc     2100

agagcccgac atctgtcacg agctgctggg ccacgtgccc ctgtttagcg atagatcctt     2160

cgcccagttt tcccaggaga tcggactggc atctctggga gcacctgacg agtacatcga     2220

gaagctggcc accatctatt ggttcacagt ggagtttggc ctgtgcaagc agggcgatag     2280

catcaaggcc tacggagcag gactgctgtc tagcttcggc gagctgcagt attgtctgtc     2340

cgagaagcca aagctgctgc ccctggagct ggagaagacc gccatccaga actacaccgt     2400

gacagagttc cagcccctgt actatgtggc cgagtctttt aacgatgcca aggagaaggt     2460

gagaaatttc gccgccacaa tccctaggcc cttcagcgtg cggtacgacc cttataccca     2520

gaggatcgag gtgctggata atacacagca gctgaagatc ctggctgact caatcaatag     2580

cgaaatcgga atcctgtgct ccgccctgca gaaaatcaaa tgaggtaccg atccagacat     2640

gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt     2700

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca     2760

agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt     2820

tttttaagga tccctgggat gggatgtgga atccttctag atttcttttg taatatttat     2880

aaagtgctct cagcaaggta tcaaaatggc aaaattgtga gtaactatcc tcctttcatt     2940

ttgggaagaa gatgaggcat gaagagaatt cagacagaaa cttactcaga ccaggggagg     3000

cagaaactaa gcagagagga aaatgaccaa gagttagccc tgggcatgga atgtgaaaga     3060

accctaaacg tgacttggaa ataatgccca aggtatattc cattctccgg gatttgttgg     3120

cattttcttg aggtgaagaa ttgcagaata cattctttaa tgtgacctac atatttaccc     3180

atgggaggaa gtctgctcct ggactcttga gattcagtca taaagcccag gccagggaaa     3240

taatgtaagt ctgcaggccc ctgtcatcag taggattagg gagaagagtt ctcagtagaa     3300

aacagggagg ctggagagaa aagaatggtt aatgttaacg ttaatataac tagaaagact     3360

gcagaactta ggactgattt ttatttgaat ccttaaaaaa aaaaatttct tatgaaaata     3420

gtacatggct cttaggagac agaacttatt gtacagagga acagcgtgag agtcagagtg     3480

atcccagaac aggtcctggc tccatcctgc acatagtttt ggtgctgctg gcaatacggt     3540

ccccacaact gtgggaaggg gttaggggca gggatctcat caggaaagca taggggttta     3600

aagttcttta tagagcactt agaagattga gaatccacaa attatattaa taacaaacaa     3660

agtagtgtcg tgttatatag taaatgtgaa tttgcagaca catttaggga aaagttataa     3720

ttaaaaaaat aggctgtata tatacctgca ggtctagata cgtagataag tagcatggcg     3780

ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg     3840

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     3900

cggcctcagt gagcgagcga gcgcgcagag agggagtggc caa                       3943


<210>  64
<211>  912
<212>  DNA
<213>  Homo sapiens

<400>  64
atgtccactg cggtcctgga aaacccaggc ttgggcagga aactctctga ctttggacag       60

gaaacaagct atattgaaga caactgcaat caaaatggtg ccatatcact gatcttctca      120

ctcaaagaag aagttggtgc attggccaaa gtattgcgct tatttgagga gaatgatgta      180

aacctgaccc acattgaatc tagaccttct cgtttaaaga aagatgagta tgaatttttc      240

acccatttgg ataaacgtag cctgcctgct ctgacaaaca tcatcaagat cttgaggcat      300

gacattggtg ccactgtcca tgagctttca cgagataaga agaaagacac agtgccctgg      360

ttcccaagaa ccattcaaga gctggacaga tttgccaatc agattctcag ctatggagcg      420

gaactggatg ctgaccaccc tggttttaaa gatcctgtgt accgtgcaag acggaagcag      480

tttgctgaca ttgcctacaa ctaccgccat gggcagccca tccctcgagt ggaatacatg      540

gaggaagaaa agaaaacatg gggcacagtg ttcaagactc tgaagtcctt gtataaaacc      600

catgcttgct atgagtacaa tcacattttt ccacttcttg aaaagtactg tggcttccat      660

gaagataaca ttccccagct ggaagacgtt tctcagttcc tgcagacttg cactggtttc      720

cgcctccgac ctgtggctgg cctgctttcc tctcgggatt tcttgggtgg cctggccttc      780

cgagtcttcc actgcacaca gtacatcaga catggatcca agcccatgta tacccccgaa      840

cctgacatct gccatgagct gttgggacat gtgcccttgt tttcagatcg cagctttgcc      900

cagttttccc ag                                                          912


<210>  65
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  from start codon to end of exon 8 of silently altered PAH coding 
       sequence

<400>  65
atgtccaccg ctgtgctgga gaaccctggg ctggggagga aactgtcaga cttcgggcag       60

gagacttcat acattgagga taactgtaac cagaatggcg ccatctctct gatcttcagc      120

ctgaaggagg aagtgggcgc cctggcaaag gtgctgcgcc tgtttgagga gaacgacgtg      180

aatctgaccc acatcgagtc ccggccttct agactgaaga aggacgagta cgagttcttt      240

acccacctgg ataagcggtc cctgccagcc ctgacaaaca tcatcaagat cctgaggcac      300

gacatcggag caaccgtgca cgagctgtct cgggacaaga agaaggatac cgtgccctgg      360

ttccctcgga caatccagga gctggataga tttgccaacc agatcctgtc ttacggagca      420

gagctggacg cagatcaccc tggcttcaag gacccagtgt atcgggcccg gagaaagcag      480

tttgccgata tcgcctacaa ttataggcac ggacagccaa tccctcgcgt ggagtatatg      540

gaggaggaga agaagacctg gggcacagtg ttcaagaccc tgaagagcct gtacaagaca      600

cacgcctgct acgagtataa ccacatcttc cccctgctgg agaagtattg tggctttcac      660

gaggacaata tccctcagct ggaggacgtg agccagttcc tgcagacctg cacaggcttt      720

aggctgaggc cagtggcagg actgctgagc tcccgggact tcctgggagg actggccttc      780

agagtgtttc actgcaccca gtacatcagg cacggctcca agccaatgta tacaccagag      840

cccgacatct gtcacgagct gctgggccac gtgcccctgt ttagcgatag atccttcgcc      900

cagttttccc ag                                                          912


<210>  66
<211>  447
<212>  DNA
<213>  Homo sapiens

<400>  66
gaaattggcc ttgcctctct gggtgcacct gatgaataca ttgaaaagct cgccacaatt       60

tactggttta ctgtggagtt tgggctctgc aaacaaggag actccataaa ggcatatggt      120

gctgggctcc tgtcatcctt tggtgaatta cagtactgct tatcagagaa gccaaagctt      180

ctccccctgg agctggagaa gacagccatc caaaattaca ctgtcacgga gttccagccc      240

ctctattacg tggcagagag ttttaatgat gccaaggaga aagtaaggaa ctttgctgcc      300

acaatacctc ggcccttctc agttcgctac gacccataca cccaaaggat tgaggtcttg      360

gacaataccc agcagcttaa gattttggct gattccatta acagtgaaat tggaatcctt      420

tgcagtgccc tccagaaaat aaagtaa                                          447


<210>  67
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  from start of exon 9 to stop codon of silently altered PAH coding
       sequence

<400>  67
gagatcggac tggcatctct gggagcacct gacgagtaca tcgagaagct ggccaccatc       60

tattggttca cagtggagtt tggcctgtgc aagcagggcg atagcatcaa ggcctacgga      120

gcaggactgc tgtctagctt cggcgagctg cagtattgtc tgtccgagaa gccaaagctg      180

ctgcccctgg agctggagaa gaccgccatc cagaactaca ccgtgacaga gttccagccc      240

ctgtactatg tggccgagtc ttttaacgat gccaaggaga aggtgagaaa tttcgccgcc      300

acaatcccta ggcccttcag cgtgcggtac gacccttata cccagaggat cgaggtgctg      360

gataatacac agcagctgaa gatcctggct gactcaatca atagcgaaat cggaatcctg      420

tgctccgccc tgcagaaaat caaatga                                          447


<210>  68
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modification to glucocorticoid binding site

<400>  68
acgctgttct tcgcc                                                        15


<210>  69
<211>  800
<212>  DNA
<213>  Homo sapiens

<400>  69
tatcttccat ttactgagtg tttatgtgga agaactgtac taaattttaa tgcatttctt       60

tattcctatt cttaaaacct tccagcaagg tggctctacc accctctttt ccgagcttca      120

ggagcagttg tgcgaatagc tggagaacac caggctggat ttaaacccag atcgctctta      180

catttgctct ttacctgctg tgctcagcgt tcacgtgccc tctagctgta gttttctgaa      240

gtcagcgcac agcaaggcag tgtgcttaga ggttaacaga agggaaaaca acaacaacaa      300

aaatctaaat gagaatcctg actgtttcag ctgggggtaa ggggggcgga ttattcatat      360

aattgttata ccagacggtc gcaggcttag tccaattgca gagaactcgc ttcccaggct      420

tctgagagtc ccggaagtgc ctaaacctgt ctaatcgacg gggcttgggt ggcccgtcgc      480

tccctggctt cttcccttta cccagggcgg gcagcgaagt ggtgcctcct gcgtccccca      540

caccctccct cagcccctcc cctccggccc gtcctgggca ggtgacctgg agcatccggc      600

aggctgccct ggcctcctgc gtcaggacaa cgcccacgag gggcgttact gtgcggagat      660

gcaccacgca agagacaccc tttgtaactc tcttctcctc cctagtgcga ggttaaaacc      720

ttcagcccca cgtgctgttt gcaaacctgc ctgtacctga ggccctaaaa agccagagac      780

ctcactcccg gggagccagc                                                  800


<210>  70
<211>  800
<212>  DNA
<213>  Homo sapiens

<400>  70
tccactgcgg tcctggaaaa cccaggcttg ggcaggaaac tctctgactt tggacaggtg       60

agccacggca gcctgagctg ctcagttagg ggaatttggg cctccagaga aagagatccg      120

aagactgctg gtgcttcctg gtttcataag ctcagtaaga agtctgaatt cgttggaagc      180

tgatgagaat atccaggaag tcaacagaca aatgtcctca acaattgttt ctaagtagga      240

gaacatctgt cctcggtggc tttcacagga atgaatgacc attgctttag ggggttgggg      300

atctggcctc cagaactgcc accaattagc tgtgtgtctt tggacaagtt actgtccctc      360

tctgttgtct gtttactctt ctgtacactg aaggggctgg tccctaatga tctgggatgg      420

gatgtggaat ccttctagat ttcttttgta atatttataa agtgctctca gcaaggtatc      480

aaaatggcaa aattgtgagt aactatcctc ctttcatttt gggaagaaga tgaggcatga      540

agagaattca gacagaaact tactcagacc aggggaggca gaaactaagc agagaggaaa      600

atgaccaaga gttagccctg ggcatggaat gtgaaagaac cctaaacgtg acttggaaat      660

aatgcccaag gtatattcca ttctccggga tttgttggca ttttcttgag gtgaagaatt      720

gcagaataca ttctttaatg tgacctacat atttacccat gggaggaagt ctgctcctgg      780

actcttgaga ttcagtcata                                                  800


<210>  71
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  targeted integration restriction cassette

<400>  71
tacgtacgat cgtcga                                                       16


<210>  72
<211>  800
<212>  DNA
<213>  Homo sapiens

<400>  72
aatggttcca aaattttcta tggttaagaa tcacctggga tggttttgaa atggcagatt       60

ctaagacaac ttgattcaac aggtttaggt aaagcccagg gaactgcatt ataagaagga      120

atcacctgta attttggagt caagatccaa ggaacactca ttgagaaaca ctgatttaca      180

aagtgcatgg agagaaatgg agcaagtgaa gggggatcag catggtgaaa tataggctgt      240

taggagtgct attgactaac tgtctggtga ctggaccaga gtaaatcttt tactttgcaa      300

gaaacaggac taaattccca tattatgtcc atagcaaagg gaattatgta gaaaaattga      360

taattaggag cctgagttct tgaccagcct ccactaccta tgtggcctca ggtgagttat      420

tttctccctt tggctctaag ttttccccat ctgtaatgta agggagttta actagatgag      480

cactaaggac aaatcaattt ctgtgagtca attattatga aataccatgt gggcatcaaa      540

tgccaagtgg aaagcataga taaagaagtg attgtgcacc tgggctgagg ggaacaaaca      600

tttcctaaga gaattgagac ccaaaagagc ctttaaggaa ggtgagatct tggaaaggga      660

aatttggtga atactctaat gaggagctaa aaaggcaaga aagaaagcag cttggctgga      720

aaggaggttc ctgtaggtgg gcctccagag attcggtacc acagaaactg ccaaacatca      780

gcaagaagcc atggggatgg                                                  800


<210>  73
<211>  800
<212>  DNA
<213>  Homo sapiens

<400>  73
agcgtttgag ggattctaaa tagaaggaca agagtaaaaa tgtcaggctg gatcgatgca       60

ggccactaag aaatggattc aggtgatggc agtgggaaga aaggacctga tgcccagagg      120

catttctgga gaagatgaga tcagacttgt gattggctga acacacactg tagtggggtg      180

gggtttaggg ggtgactcaa cttcaagccc aggtacattc aagtctgaat tgccctagtc      240

aaaagtggca tctgtggatg tgtatcagaa atatcttact tttcttggaa gccaacagga      300

gaaaagagtg ctaccaagtg aactagagac aggaatatct tttgtcattt caaggaaact      360

ggaaagaaga aggctcagta ttctttagta ggaagaagac ttaagtcaga gactcatctg      420

tacctctctg gcagggttta aaagggggaa gaggaataga ggctgcaaga gattgtgatt      480

catggacagt atgcagagat caaatgacct gggttcagat cctggctcca ctgctaactg      540

tgtaactata ggcaagttcc ttaacctctc taagccttaa tcttgtcatc aataaaaggg      600

ggcacttggt gcctaataaa acctacctct taggttgttg ccaaattaca tgagataatc      660

caaatcaagt gcttattata atacccagaa attataggct ctaaataaat gtttatatag      720

gctctaaata aatgaagttt tttagaaaga taacatcatg atcaaaatgg gatatttaac      780

agtttagtct tccatttcat                                                  800


<210>  74
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A element

<400>  74
agatctggca gcggagaggg cagaggaagt cttctaacat gcggtgacgt ggaggagaat       60

cccggcccta gg                                                           72


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ribosomal skipping peptide consensus sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  D or G

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  V or I

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  any amino acid residue

<400>  75

Xaa Xaa Glu Xaa Asn Pro Gly Pro 
1               5               


<210>  76
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A peptide

<400>  76

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  77
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A peptide

<400>  77

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  78
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A element

<400>  78
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccct             54


<210>  79
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A element

<400>  79
gctactaact tcagcctgct gaagcaggct ggagacgtgg aggagaaccc tggacct          57


<210>  80
<211>  1489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAH intron-inserted silently altered coding sequence (human HBB 
       first intron)

<400>  80
atgtccaccg ctgtgctgga gaaccctggg ctggggagga aactgtcaga cttcgggcag       60

gagacttcat acattgagga taactgtaac cagaatggcg ccatctctct gatcttcagc      120

ctgaaggagg aagtgggcgc cctggcaaag gtgctgcgcc tgtttgagga gaacgacgtg      180

aatctgaccc acatcgagtc ccggccttct agactgaaga aggacgagta cgagttcttt      240

acccacctgg ataagcggtc cctgccagcc ctgacaaaca tcatcaagat cctgaggcac      300

gacatcggag caaccgtgca cgagctgtct cgggacaaga agaaggatac cgtgccctgg      360

ttccctcgga caatccagga gctggataga tttgccaacc agatcctgtc ttacggagca      420

gagctggacg cagatcaccc tggcttcaag gacccagtgt atcgggcccg gagaaagcag      480

tttgccgata tcgcctacaa ttataggcac ggacagccaa tccctcgcgt ggagtatatg      540

gaggaggaga agaagacctg gggcacagtg ttcaagaccc tgaagagcct gtacaagaca      600

cacgcctgct acgagtataa ccacatcttc cccctgctgg agaagtattg tggctttcac      660

gaggacaata tccctcagct ggaggacgtg agccagttcc tgcagacctg cacaggcttt      720

aggctgaggc cagtggcagg actgctgagc tcccgggact tcctgggagg actggccttc      780

agagtgtttc actgcaccca gtacatcagg cacggctcca agccaatgta tacaccagag      840

cccgacatct gtcacgagct gctgggccac gtgcccctgt ttagcgatag atccttcgcc      900

cagttttccc aggttggtat caaggttaca agacaggttt aaggagacca atagaaactg      960

ggcatgtgga gacagagaag actcttgggt ttctgatagg cactgactct ctctgcctat     1020

tggtctattt tcccaccctt aggagatcgg actggcatct ctgggagcac ctgacgagta     1080

catcgagaag ctggccacca tctattggtt cacagtggag tttggcctgt gcaagcaggg     1140

cgatagcatc aaggcctacg gagcaggact gctgtctagc ttcggcgagc tgcagtattg     1200

tctgtccgag aagccaaagc tgctgcccct ggagctggag aagaccgcca tccagaacta     1260

caccgtgaca gagttccagc ccctgtacta tgtggccgag tcttttaacg atgccaagga     1320

gaaggtgaga aatttcgccg ccacaatccc taggcccttc agcgtgcggt acgaccctta     1380

tacccagagg atcgaggtgc tggataatac acagcagctg aagatcctgg ctgactcaat     1440

caatagcgaa atcggaatcc tgtgctccgc cctgcagaaa atcaaatga                 1489


<210>  81
<211>  1475
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAH intron-inserted silently altered coding sequence (mouse HBB 
       first intron)

<400>  81
atgtccaccg ctgtgctgga gaaccctggg ctggggagga aactgtcaga cttcgggcag       60

gagacttcat acattgagga taactgtaac cagaatggcg ccatctctct gatcttcagc      120

ctgaaggagg aagtgggcgc cctggcaaag gtgctgcgcc tgtttgagga gaacgacgtg      180

aatctgaccc acatcgagtc ccggccttct agactgaaga aggacgagta cgagttcttt      240

acccacctgg ataagcggtc cctgccagcc ctgacaaaca tcatcaagat cctgaggcac      300

gacatcggag caaccgtgca cgagctgtct cgggacaaga agaaggatac cgtgccctgg      360

ttccctcgga caatccagga gctggataga tttgccaacc agatcctgtc ttacggagca      420

gagctggacg cagatcaccc tggcttcaag gacccagtgt atcgggcccg gagaaagcag      480

tttgccgata tcgcctacaa ttataggcac ggacagccaa tccctcgcgt ggagtatatg      540

gaggaggaga agaagacctg gggcacagtg ttcaagaccc tgaagagcct gtacaagaca      600

cacgcctgct acgagtataa ccacatcttc cccctgctgg agaagtattg tggctttcac      660

gaggacaata tccctcagct ggaggacgtg agccagttcc tgcagacctg cacaggcttt      720

aggctgaggc cagtggcagg actgctgagc tcccgggact tcctgggagg actggccttc      780

agagtgtttc actgcaccca gtacatcagg cacggctcca agccaatgta tacaccagag      840

cccgacatct gtcacgagct gctgggccac gtgcccctgt ttagcgatag atccttcgcc      900

cagttttccc aggttggtat ccaggttaca aggcagctca caagaagaag ttgggtgctt      960

ggagacagag gtctgctttc cagcagacac taactttcag tgtcccctgt ctatgtttcc     1020

ctttttagga gatcggactg gcatctctgg gagcacctga cgagtacatc gagaagctgg     1080

ccaccatcta ttggttcaca gtggagtttg gcctgtgcaa gcagggcgat agcatcaagg     1140

cctacggagc aggactgctg tctagcttcg gcgagctgca gtattgtctg tccgagaagc     1200

caaagctgct gcccctggag ctggagaaga ccgccatcca gaactacacc gtgacagagt     1260

tccagcccct gtactatgtg gccgagtctt ttaacgatgc caaggagaag gtgagaaatt     1320

tcgccgccac aatccctagg cccttcagcg tgcggtacga cccttatacc cagaggatcg     1380

aggtgctgga taatacacag cagctgaaga tcctggctga ctcaatcaat agcgaaatcg     1440

gaatcctgtg ctccgccctg cagaaaatca aatga                                1475


<210>  82
<211>  1451
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAH intron-inserted silently altered coding sequence (MVM intron)

<400>  82
atgtccaccg ctgtgctgga gaaccctggg ctggggagga aactgtcaga cttcgggcag       60

gagacttcat acattgagga taactgtaac cagaatggcg ccatctctct gatcttcagc      120

ctgaaggagg aagtgggcgc cctggcaaag gtgctgcgcc tgtttgagga gaacgacgtg      180

aatctgaccc acatcgagtc ccggccttct agactgaaga aggacgagta cgagttcttt      240

acccacctgg ataagcggtc cctgccagcc ctgacaaaca tcatcaagat cctgaggcac      300

gacatcggag caaccgtgca cgagctgtct cgggacaaga agaaggatac cgtgccctgg      360

ttccctcgga caatccagga gctggataga tttgccaacc agatcctgtc ttacggagca      420

gagctggacg cagatcaccc tggcttcaag gacccagtgt atcgggcccg gagaaagcag      480

tttgccgata tcgcctacaa ttataggcac ggacagccaa tccctcgcgt ggagtatatg      540

gaggaggaga agaagacctg gggcacagtg ttcaagaccc tgaagagcct gtacaagaca      600

cacgcctgct acgagtataa ccacatcttc cccctgctgg agaagtattg tggctttcac      660

gaggacaata tccctcagct ggaggacgtg agccagttcc tgcagacctg cacaggcttt      720

aggctgaggc cagtggcagg actgctgagc tcccgggact tcctgggagg actggccttc      780

agagtgtttc actgcaccca gtacatcagg cacggctcca agccaatgta tacaccagag      840

cccgacatct gtcacgagct gctgggccac gtgcccctgt ttagcgatag atccttcgcc      900

cagttttccc agaagaggta agggtttaag ggatggttgg ttggtggggt attaatgttt      960

aattacctgg agcacctgcc tgaaatcact ttttttcagg ttgggagatc ggactggcat     1020

ctctgggagc acctgacgag tacatcgaga agctggccac catctattgg ttcacagtgg     1080

agtttggcct gtgcaagcag ggcgatagca tcaaggccta cggagcagga ctgctgtcta     1140

gcttcggcga gctgcagtat tgtctgtccg agaagccaaa gctgctgccc ctggagctgg     1200

agaagaccgc catccagaac tacaccgtga cagagttcca gcccctgtac tatgtggccg     1260

agtcttttaa cgatgccaag gagaaggtga gaaatttcgc cgccacaatc cctaggccct     1320

tcagcgtgcg gtacgaccct tatacccaga ggatcgaggt gctggataat acacagcagc     1380

tgaagatcct ggctgactca atcaatagcg aaatcggaat cctgtgctcc gccctgcaga     1440

aaatcaaatg a                                                          1451


<210>  83
<211>  1607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pHMI-hPAH-hAC-008 editing element

<400>  83
atgtccaccg ctgtgctgga gaaccctggg ctggggagga aactgtcaga cttcgggcag       60

gagacttcat acattgagga taactgtaac cagaatggcg ccatctctct gatcttcagc      120

ctgaaggagg aagtgggcgc cctggcaaag gtgctgcgcc tgtttgagga gaacgacgtg      180

aatctgaccc acatcgagtc ccggccttct agactgaaga aggacgagta cgagttcttt      240

acccacctgg ataagcggtc cctgccagcc ctgacaaaca tcatcaagat cctgaggcac      300

gacatcggag caaccgtgca cgagctgtct cgggacaaga agaaggatac cgtgccctgg      360

ttccctcgga caatccagga gctggataga tttgccaacc agatcctgtc ttacggagca      420

gagctggacg cagatcaccc tggcttcaag gacccagtgt atcgggcccg gagaaagcag      480

tttgccgata tcgcctacaa ttataggcac ggacagccaa tccctcgcgt ggagtatatg      540

gaggaggaga agaagacctg gggcacagtg ttcaagaccc tgaagagcct gtacaagaca      600

cacgcctgct acgagtataa ccacatcttc cccctgctgg agaagtattg tggctttcac      660

gaggacaata tccctcagct ggaggacgtg agccagttcc tgcagacctg cacaggcttt      720

aggctgaggc cagtggcagg actgctgagc tcccgggact tcctgggagg actggccttc      780

agagtgtttc actgcaccca gtacatcagg cacggctcca agccaatgta tacaccagag      840

cccgacatct gtcacgagct gctgggccac gtgcccctgt ttagcgatag atccttcgcc      900

cagttttccc aggagatcgg actggcatct ctgggagcac ctgacgagta catcgagaag      960

ctggccacca tctattggtt cacagtggag tttggcctgt gcaagcaggg cgatagcatc     1020

aaggcctacg gagcaggact gctgtctagc ttcggcgagc tgcagtattg tctgtccgag     1080

aagccaaagc tgctgcccct ggagctggag aagaccgcca tccagaacta caccgtgaca     1140

gagttccagc ccctgtacta tgtggccgag tcttttaacg atgccaagga gaaggtgaga     1200

aatttcgccg ccacaatccc taggcccttc agcgtgcggt acgaccctta tacccagagg     1260

atcgaggtgc tggataatac acagcagctg aagatcctgg ctgactcaat caatagcgaa     1320

atcggaatcc tgtgctccgc cctgcagaaa atcaaatgag aattcaaggc ctctcgagcc     1380

tctagaacta tagtgagtcg tattacgtag atccagacat gataagatac attgatgagt     1440

ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg     1500

ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca     1560

ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaa                   1607


<210>  84
<211>  1719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pHMI-hPAH-h1C-007 editing element

<400>  84
ctgacctctt ctcttcctcc cacagggcgg taccagatct ggcagcggag agggcagagg       60

aagtcttcta acatgcggtg acgtggagga gaatcccggc cctaggggta ccatgtccac      120

cgctgtgctg gagaaccctg ggctggggag gaaactgtca gacttcgggc aggagacttc      180

atacattgag gataactgta accagaatgg cgccatctct ctgatcttca gcctgaagga      240

ggaagtgggc gccctggcaa aggtgctgcg cctgtttgag gagaacgacg tgaatctgac      300

ccacatcgag tcccggcctt ctagactgaa gaaggacgag tacgagttct ttacccacct      360

ggataagcgg tccctgccag ccctgacaaa catcatcaag atcctgaggc acgacatcgg      420

agcaaccgtg cacgagctgt ctcgggacaa gaagaaggat accgtgccct ggttccctcg      480

gacaatccag gagctggata gatttgccaa ccagatcctg tcttacggag cagagctgga      540

cgcagatcac cctggcttca aggacccagt gtatcgggcc cggagaaagc agtttgccga      600

tatcgcctac aattataggc acggacagcc aatccctcgc gtggagtata tggaggagga      660

gaagaagacc tggggcacag tgttcaagac cctgaagagc ctgtacaaga cacacgcctg      720

ctacgagtat aaccacatct tccccctgct ggagaagtat tgtggctttc acgaggacaa      780

tatccctcag ctggaggacg tgagccagtt cctgcagacc tgcacaggct ttaggctgag      840

gccagtggca ggactgctga gctcccggga cttcctggga ggactggcct tcagagtgtt      900

tcactgcacc cagtacatca ggcacggctc caagccaatg tatacaccag agcccgacat      960

ctgtcacgag ctgctgggcc acgtgcccct gtttagcgat agatccttcg cccagttttc     1020

ccaggagatc ggactggcat ctctgggagc acctgacgag tacatcgaga agctggccac     1080

catctattgg ttcacagtgg agtttggcct gtgcaagcag ggcgatagca tcaaggccta     1140

cggagcagga ctgctgtcta gcttcggcga gctgcagtat tgtctgtccg agaagccaaa     1200

gctgctgccc ctggagctgg agaagaccgc catccagaac tacaccgtga cagagttcca     1260

gcccctgtac tatgtggccg agtcttttaa cgatgccaag gagaaggtga gaaatttcgc     1320

cgccacaatc cctaggccct tcagcgtgcg gtacgaccct tatacccaga ggatcgaggt     1380

gctggataat acacagcagc tgaagatcct ggctgactca atcaatagcg aaatcggaat     1440

cctgtgctcc gccctgcaga aaatcaaatg agaattcaag gcctctcgag cctctagaac     1500

tatagtgagt cgtattacgt agatccagac atgataagat acattgatga gtttggacaa     1560

accacaacta gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga tgctattgct     1620

ttatttgtaa ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt     1680

atgtttcagg ttcaggggga ggtgtgggag gttttttaa                            1719


<210>  85
<211>  3227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pHMI-hPAH-hAC-008 correction genome from 5' homology arm to 3' 
       homology arm

<400>  85
tatcttccat ttactgagtg tttatgtgga agaactgtac taaattttaa tgcatttctt       60

tattcctatt cttaaaacct tccagcaagg tggctctacc accctctttt ccgagcttca      120

ggagcagttg tgcgaatagc tggagaacac caggctggat ttaaacccag atcgctctta      180

catttgctct ttacctgctg tgctcagcgt tcacgtgccc tctagctgta gttttctgaa      240

gtcagcgcac agcaaggcag tgtgcttaga ggttaacaga agggaaaaca acaacaacaa      300

aaatctaaat gagaatcctg actgtttcag ctgggggtaa ggggggcgga ttattcatat      360

aattgttata ccagacggtc gcaggcttag tccaattgca gagaactcgc ttcccaggct      420

tctgagagtc ccggaagtgc ctaaacctgt ctaatcgacg gggcttgggt ggcccgtcgc      480

tccctggctt cttcccttta cccagggcgg gcagcgaagt ggtgcctcct gcgtccccca      540

caccctccct cagcccctcc cctccggccc gtcctgggca ggtgacctgg agcatccggc      600

aggctgccct ggcctcctgc gtcaggacaa cgcccacgag gggcgttact gtgcggagat      660

gcaccacgca agagacaccc tttgtaactc tcttctcctc cctagtgcga ggttaaaacc      720

ttcagcccca cgtgctgttt gcaaacctgc ctgtacctga ggccctaaaa agccagagac      780

ctcactcccg gggagccagc atgtccaccg ctgtgctgga gaaccctggg ctggggagga      840

aactgtcaga cttcgggcag gagacttcat acattgagga taactgtaac cagaatggcg      900

ccatctctct gatcttcagc ctgaaggagg aagtgggcgc cctggcaaag gtgctgcgcc      960

tgtttgagga gaacgacgtg aatctgaccc acatcgagtc ccggccttct agactgaaga     1020

aggacgagta cgagttcttt acccacctgg ataagcggtc cctgccagcc ctgacaaaca     1080

tcatcaagat cctgaggcac gacatcggag caaccgtgca cgagctgtct cgggacaaga     1140

agaaggatac cgtgccctgg ttccctcgga caatccagga gctggataga tttgccaacc     1200

agatcctgtc ttacggagca gagctggacg cagatcaccc tggcttcaag gacccagtgt     1260

atcgggcccg gagaaagcag tttgccgata tcgcctacaa ttataggcac ggacagccaa     1320

tccctcgcgt ggagtatatg gaggaggaga agaagacctg gggcacagtg ttcaagaccc     1380

tgaagagcct gtacaagaca cacgcctgct acgagtataa ccacatcttc cccctgctgg     1440

agaagtattg tggctttcac gaggacaata tccctcagct ggaggacgtg agccagttcc     1500

tgcagacctg cacaggcttt aggctgaggc cagtggcagg actgctgagc tcccgggact     1560

tcctgggagg actggccttc agagtgtttc actgcaccca gtacatcagg cacggctcca     1620

agccaatgta tacaccagag cccgacatct gtcacgagct gctgggccac gtgcccctgt     1680

ttagcgatag atccttcgcc cagttttccc aggagatcgg actggcatct ctgggagcac     1740

ctgacgagta catcgagaag ctggccacca tctattggtt cacagtggag tttggcctgt     1800

gcaagcaggg cgatagcatc aaggcctacg gagcaggact gctgtctagc ttcggcgagc     1860

tgcagtattg tctgtccgag aagccaaagc tgctgcccct ggagctggag aagaccgcca     1920

tccagaacta caccgtgaca gagttccagc ccctgtacta tgtggccgag tcttttaacg     1980

atgccaagga gaaggtgaga aatttcgccg ccacaatccc taggcccttc agcgtgcggt     2040

acgaccctta tacccagagg atcgaggtgc tggataatac acagcagctg aagatcctgg     2100

ctgactcaat caatagcgaa atcggaatcc tgtgctccgc cctgcagaaa atcaaatgag     2160

aattcaaggc ctctcgagcc tctagaacta tagtgagtcg tattacgtag atccagacat     2220

gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt     2280

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca     2340

agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt     2400

tttttaagct ttacgtacga tcgtcgatcc actgcggtcc tggaaaaccc aggcttgggc     2460

aggaaactct ctgactttgg acaggtgagc cacggcagcc tgagctgctc agttagggga     2520

atttgggcct ccagagaaag agatccgaag actgctggtg cttcctggtt tcataagctc     2580

agtaagaagt ctgaattcgt tggaagctga tgagaatatc caggaagtca acagacaaat     2640

gtcctcaaca attgtttcta agtaggagaa catctgtcct cggtggcttt cacaggaatg     2700

aatgaccatt gctttagggg gttggggatc tggcctccag aactgccacc aattagctgt     2760

gtgtctttgg acaagttact gtccctctct gttgtctgtt tactcttctg tacactgaag     2820

gggctggtcc ctaatgatct gggatgggat gtggaatcct tctagatttc ttttgtaata     2880

tttataaagt gctctcagca aggtatcaaa atggcaaaat tgtgagtaac tatcctcctt     2940

tcattttggg aagaagatga ggcatgaaga gaattcagac agaaacttac tcagaccagg     3000

ggaggcagaa actaagcaga gaggaaaatg accaagagtt agccctgggc atggaatgtg     3060

aaagaaccct aaacgtgact tggaaataat gcccaaggta tattccattc tccgggattt     3120

gttggcattt tcttgaggtg aagaattgca gaatacattc tttaatgtga cctacatatt     3180

tacccatggg aggaagtctg ctcctggact cttgagattc agtcata                   3227


<210>  86
<211>  3345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pHMI-hPAH-h1C-007 correction genome from 5' homology arm to 3' 
       homology arm

<400>  86
aatggttcca aaattttcta tggttaagaa tcacctggga tggttttgaa atggcagatt       60

ctaagacaac ttgattcaac aggtttaggt aaagcccagg gaactgcatt ataagaagga      120

atcacctgta attttggagt caagatccaa ggaacactca ttgagaaaca ctgatttaca      180

aagtgcatgg agagaaatgg agcaagtgaa gggggatcag catggtgaaa tataggctgt      240

taggagtgct attgactaac tgtctggtga ctggaccaga gtaaatcttt tactttgcaa      300

gaaacaggac taaattccca tattatgtcc atagcaaagg gaattatgta gaaaaattga      360

taattaggag cctgagttct tgaccagcct ccactaccta tgtggcctca ggtgagttat      420

tttctccctt tggctctaag ttttccccat ctgtaatgta agggagttta actagatgag      480

cactaaggac aaatcaattt ctgtgagtca attattatga aataccatgt gggcatcaaa      540

tgccaagtgg aaagcataga taaagaagtg attgtgcacc tgggctgagg ggaacaaaca      600

tttcctaaga gaattgagac ccaaaagagc ctttaaggaa ggtgagatct tggaaaggga      660

aatttggtga atactctaat gaggagctaa aaaggcaaga aagaaagcag cttggctgga      720

aaggaggttc ctgtaggtgg gcctccagag attcggtacc acagaaactg ccaaacatca      780

gcaagaagcc atggggatgg aagcttctga cctcttctct tcctcccaca gggcggtacc      840

agatctggca gcggagaggg cagaggaagt cttctaacat gcggtgacgt ggaggagaat      900

cccggcccta ggggtaccat gtccaccgct gtgctggaga accctgggct ggggaggaaa      960

ctgtcagact tcgggcagga gacttcatac attgaggata actgtaacca gaatggcgcc     1020

atctctctga tcttcagcct gaaggaggaa gtgggcgccc tggcaaaggt gctgcgcctg     1080

tttgaggaga acgacgtgaa tctgacccac atcgagtccc ggccttctag actgaagaag     1140

gacgagtacg agttctttac ccacctggat aagcggtccc tgccagccct gacaaacatc     1200

atcaagatcc tgaggcacga catcggagca accgtgcacg agctgtctcg ggacaagaag     1260

aaggataccg tgccctggtt ccctcggaca atccaggagc tggatagatt tgccaaccag     1320

atcctgtctt acggagcaga gctggacgca gatcaccctg gcttcaagga cccagtgtat     1380

cgggcccgga gaaagcagtt tgccgatatc gcctacaatt ataggcacgg acagccaatc     1440

cctcgcgtgg agtatatgga ggaggagaag aagacctggg gcacagtgtt caagaccctg     1500

aagagcctgt acaagacaca cgcctgctac gagtataacc acatcttccc cctgctggag     1560

aagtattgtg gctttcacga ggacaatatc cctcagctgg aggacgtgag ccagttcctg     1620

cagacctgca caggctttag gctgaggcca gtggcaggac tgctgagctc ccgggacttc     1680

ctgggaggac tggccttcag agtgtttcac tgcacccagt acatcaggca cggctccaag     1740

ccaatgtata caccagagcc cgacatctgt cacgagctgc tgggccacgt gcccctgttt     1800

agcgatagat ccttcgccca gttttcccag gagatcggac tggcatctct gggagcacct     1860

gacgagtaca tcgagaagct ggccaccatc tattggttca cagtggagtt tggcctgtgc     1920

aagcagggcg atagcatcaa ggcctacgga gcaggactgc tgtctagctt cggcgagctg     1980

cagtattgtc tgtccgagaa gccaaagctg ctgcccctgg agctggagaa gaccgccatc     2040

cagaactaca ccgtgacaga gttccagccc ctgtactatg tggccgagtc ttttaacgat     2100

gccaaggaga aggtgagaaa tttcgccgcc acaatcccta ggcccttcag cgtgcggtac     2160

gacccttata cccagaggat cgaggtgctg gataatacac agcagctgaa gatcctggct     2220

gactcaatca atagcgaaat cggaatcctg tgctccgccc tgcagaaaat caaatgagaa     2280

ttcaaggcct ctcgagcctc tagaactata gtgagtcgta ttacgtagat ccagacatga     2340

taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta     2400

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag     2460

ttaacaacaa caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt     2520

tttaagcttt acgtacgatc gtcgaagcgt ttgagggatt ctaaatagaa ggacaagagt     2580

aaaaatgtca ggctggatcg atgcaggcca ctaagaaatg gattcaggtg atggcagtgg     2640

gaagaaagga cctgatgccc agaggcattt ctggagaaga tgagatcaga cttgtgattg     2700

gctgaacaca cactgtagtg gggtggggtt tagggggtga ctcaacttca agcccaggta     2760

cattcaagtc tgaattgccc tagtcaaaag tggcatctgt ggatgtgtat cagaaatatc     2820

ttacttttct tggaagccaa caggagaaaa gagtgctacc aagtgaacta gagacaggaa     2880

tatcttttgt catttcaagg aaactggaaa gaagaaggct cagtattctt tagtaggaag     2940

aagacttaag tcagagactc atctgtacct ctctggcagg gtttaaaagg gggaagagga     3000

atagaggctg caagagattg tgattcatgg acagtatgca gagatcaaat gacctgggtt     3060

cagatcctgg ctccactgct aactgtgtaa ctataggcaa gttccttaac ctctctaagc     3120

cttaatcttg tcatcaataa aagggggcac ttggtgccta ataaaaccta cctcttaggt     3180

tgttgccaaa ttacatgaga taatccaaat caagtgctta ttataatacc cagaaattat     3240

aggctctaaa taaatgttta tataggctct aaataaatga agttttttag aaagataaca     3300

tcatgatcaa aatgggatat ttaacagttt agtcttccat ttcat                     3345


<210>  87
<211>  3637
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pHMI-hPAH-hAC-008 correction genome from 5' ITR to 3' ITR

<400>  87
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgct atcttccatt tactgagtgt ttatgtggaa      240

gaactgtact aaattttaat gcatttcttt attcctattc ttaaaacctt ccagcaaggt      300

ggctctacca ccctcttttc cgagcttcag gagcagttgt gcgaatagct ggagaacacc      360

aggctggatt taaacccaga tcgctcttac atttgctctt tacctgctgt gctcagcgtt      420

cacgtgccct ctagctgtag ttttctgaag tcagcgcaca gcaaggcagt gtgcttagag      480

gttaacagaa gggaaaacaa caacaacaaa aatctaaatg agaatcctga ctgtttcagc      540

tgggggtaag gggggcggat tattcatata attgttatac cagacggtcg caggcttagt      600

ccaattgcag agaactcgct tcccaggctt ctgagagtcc cggaagtgcc taaacctgtc      660

taatcgacgg ggcttgggtg gcccgtcgct ccctggcttc ttccctttac ccagggcggg      720

cagcgaagtg gtgcctcctg cgtcccccac accctccctc agcccctccc ctccggcccg      780

tcctgggcag gtgacctgga gcatccggca ggctgccctg gcctcctgcg tcaggacaac      840

gcccacgagg ggcgttactg tgcggagatg caccacgcaa gagacaccct ttgtaactct      900

cttctcctcc ctagtgcgag gttaaaacct tcagccccac gtgctgtttg caaacctgcc      960

tgtacctgag gccctaaaaa gccagagacc tcactcccgg ggagccagca tgtccaccgc     1020

tgtgctggag aaccctgggc tggggaggaa actgtcagac ttcgggcagg agacttcata     1080

cattgaggat aactgtaacc agaatggcgc catctctctg atcttcagcc tgaaggagga     1140

agtgggcgcc ctggcaaagg tgctgcgcct gtttgaggag aacgacgtga atctgaccca     1200

catcgagtcc cggccttcta gactgaagaa ggacgagtac gagttcttta cccacctgga     1260

taagcggtcc ctgccagccc tgacaaacat catcaagatc ctgaggcacg acatcggagc     1320

aaccgtgcac gagctgtctc gggacaagaa gaaggatacc gtgccctggt tccctcggac     1380

aatccaggag ctggatagat ttgccaacca gatcctgtct tacggagcag agctggacgc     1440

agatcaccct ggcttcaagg acccagtgta tcgggcccgg agaaagcagt ttgccgatat     1500

cgcctacaat tataggcacg gacagccaat ccctcgcgtg gagtatatgg aggaggagaa     1560

gaagacctgg ggcacagtgt tcaagaccct gaagagcctg tacaagacac acgcctgcta     1620

cgagtataac cacatcttcc ccctgctgga gaagtattgt ggctttcacg aggacaatat     1680

ccctcagctg gaggacgtga gccagttcct gcagacctgc acaggcttta ggctgaggcc     1740

agtggcagga ctgctgagct cccgggactt cctgggagga ctggccttca gagtgtttca     1800

ctgcacccag tacatcaggc acggctccaa gccaatgtat acaccagagc ccgacatctg     1860

tcacgagctg ctgggccacg tgcccctgtt tagcgataga tccttcgccc agttttccca     1920

ggagatcgga ctggcatctc tgggagcacc tgacgagtac atcgagaagc tggccaccat     1980

ctattggttc acagtggagt ttggcctgtg caagcagggc gatagcatca aggcctacgg     2040

agcaggactg ctgtctagct tcggcgagct gcagtattgt ctgtccgaga agccaaagct     2100

gctgcccctg gagctggaga agaccgccat ccagaactac accgtgacag agttccagcc     2160

cctgtactat gtggccgagt cttttaacga tgccaaggag aaggtgagaa atttcgccgc     2220

cacaatccct aggcccttca gcgtgcggta cgacccttat acccagagga tcgaggtgct     2280

ggataataca cagcagctga agatcctggc tgactcaatc aatagcgaaa tcggaatcct     2340

gtgctccgcc ctgcagaaaa tcaaatgaga attcaaggcc tctcgagcct ctagaactat     2400

agtgagtcgt attacgtaga tccagacatg ataagataca ttgatgagtt tggacaaacc     2460

acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta     2520

tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg     2580

tttcaggttc agggggaggt gtgggaggtt ttttaagctt tacgtacgat cgtcgatcca     2640

ctgcggtcct ggaaaaccca ggcttgggca ggaaactctc tgactttgga caggtgagcc     2700

acggcagcct gagctgctca gttaggggaa tttgggcctc cagagaaaga gatccgaaga     2760

ctgctggtgc ttcctggttt cataagctca gtaagaagtc tgaattcgtt ggaagctgat     2820

gagaatatcc aggaagtcaa cagacaaatg tcctcaacaa ttgtttctaa gtaggagaac     2880

atctgtcctc ggtggctttc acaggaatga atgaccattg ctttaggggg ttggggatct     2940

ggcctccaga actgccacca attagctgtg tgtctttgga caagttactg tccctctctg     3000

ttgtctgttt actcttctgt acactgaagg ggctggtccc taatgatctg ggatgggatg     3060

tggaatcctt ctagatttct tttgtaatat ttataaagtg ctctcagcaa ggtatcaaaa     3120

tggcaaaatt gtgagtaact atcctccttt cattttggga agaagatgag gcatgaagag     3180

aattcagaca gaaacttact cagaccaggg gaggcagaaa ctaagcagag aggaaaatga     3240

ccaagagtta gccctgggca tggaatgtga aagaacccta aacgtgactt ggaaataatg     3300

cccaaggtat attccattct ccgggatttg ttggcatttt cttgaggtga agaattgcag     3360

aatacattct ttaatgtgac ctacatattt acccatggga ggaagtctgc tcctggactc     3420

ttgagattca gtcataaacc tgcaggtcta gatacgtaga taagtagcat ggcgggttaa     3480

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     3540

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     3600

cagtgagcga gcgagcgcgc agagagggag tggccaa                              3637


<210>  88
<211>  3755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pHMI-hPAH-h1C-007 correction genome from 5' ITR to 3' ITR

<400>  88
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgca atggttccaa aattttctat ggttaagaat      240

cacctgggat ggttttgaaa tggcagattc taagacaact tgattcaaca ggtttaggta      300

aagcccaggg aactgcatta taagaaggaa tcacctgtaa ttttggagtc aagatccaag      360

gaacactcat tgagaaacac tgatttacaa agtgcatgga gagaaatgga gcaagtgaag      420

ggggatcagc atggtgaaat ataggctgtt aggagtgcta ttgactaact gtctggtgac      480

tggaccagag taaatctttt actttgcaag aaacaggact aaattcccat attatgtcca      540

tagcaaaggg aattatgtag aaaaattgat aattaggagc ctgagttctt gaccagcctc      600

cactacctat gtggcctcag gtgagttatt ttctcccttt ggctctaagt tttccccatc      660

tgtaatgtaa gggagtttaa ctagatgagc actaaggaca aatcaatttc tgtgagtcaa      720

ttattatgaa ataccatgtg ggcatcaaat gccaagtgga aagcatagat aaagaagtga      780

ttgtgcacct gggctgaggg gaacaaacat ttcctaagag aattgagacc caaaagagcc      840

tttaaggaag gtgagatctt ggaaagggaa atttggtgaa tactctaatg aggagctaaa      900

aaggcaagaa agaaagcagc ttggctggaa aggaggttcc tgtaggtggg cctccagaga      960

ttcggtacca cagaaactgc caaacatcag caagaagcca tggggatgga agcttctgac     1020

ctcttctctt cctcccacag ggcggtacca gatctggcag cggagagggc agaggaagtc     1080

ttctaacatg cggtgacgtg gaggagaatc ccggccctag gggtaccatg tccaccgctg     1140

tgctggagaa ccctgggctg gggaggaaac tgtcagactt cgggcaggag acttcataca     1200

ttgaggataa ctgtaaccag aatggcgcca tctctctgat cttcagcctg aaggaggaag     1260

tgggcgccct ggcaaaggtg ctgcgcctgt ttgaggagaa cgacgtgaat ctgacccaca     1320

tcgagtcccg gccttctaga ctgaagaagg acgagtacga gttctttacc cacctggata     1380

agcggtccct gccagccctg acaaacatca tcaagatcct gaggcacgac atcggagcaa     1440

ccgtgcacga gctgtctcgg gacaagaaga aggataccgt gccctggttc cctcggacaa     1500

tccaggagct ggatagattt gccaaccaga tcctgtctta cggagcagag ctggacgcag     1560

atcaccctgg cttcaaggac ccagtgtatc gggcccggag aaagcagttt gccgatatcg     1620

cctacaatta taggcacgga cagccaatcc ctcgcgtgga gtatatggag gaggagaaga     1680

agacctgggg cacagtgttc aagaccctga agagcctgta caagacacac gcctgctacg     1740

agtataacca catcttcccc ctgctggaga agtattgtgg ctttcacgag gacaatatcc     1800

ctcagctgga ggacgtgagc cagttcctgc agacctgcac aggctttagg ctgaggccag     1860

tggcaggact gctgagctcc cgggacttcc tgggaggact ggccttcaga gtgtttcact     1920

gcacccagta catcaggcac ggctccaagc caatgtatac accagagccc gacatctgtc     1980

acgagctgct gggccacgtg cccctgttta gcgatagatc cttcgcccag ttttcccagg     2040

agatcggact ggcatctctg ggagcacctg acgagtacat cgagaagctg gccaccatct     2100

attggttcac agtggagttt ggcctgtgca agcagggcga tagcatcaag gcctacggag     2160

caggactgct gtctagcttc ggcgagctgc agtattgtct gtccgagaag ccaaagctgc     2220

tgcccctgga gctggagaag accgccatcc agaactacac cgtgacagag ttccagcccc     2280

tgtactatgt ggccgagtct tttaacgatg ccaaggagaa ggtgagaaat ttcgccgcca     2340

caatccctag gcccttcagc gtgcggtacg acccttatac ccagaggatc gaggtgctgg     2400

ataatacaca gcagctgaag atcctggctg actcaatcaa tagcgaaatc ggaatcctgt     2460

gctccgccct gcagaaaatc aaatgagaat tcaaggcctc tcgagcctct agaactatag     2520

tgagtcgtat tacgtagatc cagacatgat aagatacatt gatgagtttg gacaaaccac     2580

aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt     2640

tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt     2700

tcaggttcag ggggaggtgt gggaggtttt ttaagcttta cgtacgatcg tcgaagcgtt     2760

tgagggattc taaatagaag gacaagagta aaaatgtcag gctggatcga tgcaggccac     2820

taagaaatgg attcaggtga tggcagtggg aagaaaggac ctgatgccca gaggcatttc     2880

tggagaagat gagatcagac ttgtgattgg ctgaacacac actgtagtgg ggtggggttt     2940

agggggtgac tcaacttcaa gcccaggtac attcaagtct gaattgccct agtcaaaagt     3000

ggcatctgtg gatgtgtatc agaaatatct tacttttctt ggaagccaac aggagaaaag     3060

agtgctacca agtgaactag agacaggaat atcttttgtc atttcaagga aactggaaag     3120

aagaaggctc agtattcttt agtaggaaga agacttaagt cagagactca tctgtacctc     3180

tctggcaggg tttaaaaggg ggaagaggaa tagaggctgc aagagattgt gattcatgga     3240

cagtatgcag agatcaaatg acctgggttc agatcctggc tccactgcta actgtgtaac     3300

tataggcaag ttccttaacc tctctaagcc ttaatcttgt catcaataaa agggggcact     3360

tggtgcctaa taaaacctac ctcttaggtt gttgccaaat tacatgagat aatccaaatc     3420

aagtgcttat tataataccc agaaattata ggctctaaat aaatgtttat ataggctcta     3480

aataaatgaa gttttttaga aagataacat catgatcaaa atgggatatt taacagttta     3540

gtcttccatt tcataacctg caggtctaga tacgtagata agtagcatgg cgggttaatc     3600

attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     3660

ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca     3720

gtgagcgagc gagcgcgcag agagggagtg gccaa                                3755


<210>  89
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  89
ccaaatccca ccagctcact                                                   20


<210>  90
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  90
tcccatgaaa ctgaggtgtg a                                                 21


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAH_Genomic Set 1, primer F

<400>  91
gctccatcct gcacatagtt                                                   20


<210>  92
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAH_Genomic Set 1, primer R

<400>  92
cctatgcttt cctgatgaga tcc                                               23


<210>  93
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAH_Genomic Set 1, probe

<400>  93
ttggtgctgc tggcaatacg gtc                                               23


<210>  94
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40_FAM Set 1, primer F

<400>  94
gcaatagcat cacaaatttc ac                                                22


<210>  95
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40_FAM Set 1, primer R

<400>  95
gatccagaca tgataagata cattg                                             25


<210>  96
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40_FAM Set 1, probe

<400>  96
tcactgcatt ctagttgtgg tttgtcca                                          28


<210>  97
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAH_HA Set 1, primer F

<400>  97
tccagtcacc agacagttag t                                                 21


<210>  98
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAH_HA Set 1, primer R

<400>  98
ggagagaaat ggagcaagtg aa                                                22


<210>  99
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAH_HA Set 1, probe

<400>  99
acagcctata tttcaccatg ctgatccc                                          28


<210>  100
<211>  800
<212>  DNA
<213>  Mus musculus

<400>  100
agcattagct tccatttatg cagtgtaaat ggtgagaaca gccccgactg aatacccaga       60

gcatcatctc gtctgtgtca ttcatgcaca taacatatct cagcgaggtg gcccttctgt      120

cctctttgca gagacccagc caccatacta gtacctagag aactggctgg atttcagccc      180

cgatacctcc gggcttttgc tcatgttcgc ctcatagggt catctgggtg gttgcctaag      240

gaaaagtatg tcatggagac taacttgctt ggcattgaat aaaaggtgag ttgagagtgg      300

agcgtgttta aattgcaatc ctgcctctat ttctgtgctt gcagggaaca gtcatcctta      360

attgctatcc tccatcatca tcatgattat ttctggtttt tctctggttg cggagaatcc      420

atactccagg tattccaatg tctcagcatt gccaggcctg tctgagcgtc aggatgtagg      480

tagtctgggc tctctgcctt ctattcttgt ccaggatact ctgccaaaag aatcatgttg      540

tggctgccac ccctcccaca aagcctcccg cttgggtcag tccaggactg gagttgggta      600

tggactgttc atgtctatcc actgctacgt cagggcaaca cccactgaga gtgaccttgt      660

agactgcagt gggagacacc cttcaaaacc tctcctctcc tgtcctgaga gccaggttaa      720

aaccatcagc cccgcatcct gagtgcaaac ttttcctaac cctgctgcta agctagacac      780

ctcacttact gagagccagc                                                  800


<210>  101
<211>  800
<212>  DNA
<213>  Mus musculus

<400>  101
gcagctgttg tcctggagaa cggagtcctg agcagaaaac tctcagactt tgggcaggta       60

agcctgttgg gcttccactg ctaggagaga attggttccc cacatgtgaa agcagtctgg      120

gaaatgctgg tatttccagt ctcctaaggc tactaagaaa tatgacttta tttagaggcg      180

aggaaaatgc ccaggaagtc aactgatgag actagtctta acaagttgag gatacagaaa      240

gttggggatc tgagctgcta ccaacatctg tgtgtctttg ggtggctcat tggtatcctc      300

tgcctattgg ctttatcttc tgtacactga aaggaaatgg ctggtcctta gtcacctggg      360

gtgggagtcc ctatctctcc agggatactt attcaatcct ttcttctggg tatcaaaatg      420

acaagcttgt aagaaactgt cctctttcgg ctttcaggag gtgatgtcgc atgaagagaa      480

tttggggggg gggacttact cagaaccaag gagggagaaa ttaaacagag agggaaatga      540

acaggagtta gcccggagcc tgaagcacct tggggattat gctgggggtg gagggaatcc      600

attgtcctcc ctagggaggg cttgcagaac atgttctttt ctgtgatatt tgtactttcc      660

ccagattgca aatcatggtt tgtacactga gattcagtct ctggaggtaa tatgcctttt      720

ctagcttttc cttggacagg actaaggggt tgagggttgc ctggagtcag agaaatttgt      780

gttaaagaag gttgatatga                                                  800


<210>  102
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mPAH_ATG_gDNA_FAM Set 1, primer F

<400>  102
cagcatcaga agcagaacat tt                                                22


<210>  103
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mPAH_ATG_gDNA_FAM Set 1, primer R

<400>  103
aaagcacatc agcagtttca a                                                 21


<210>  104
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mPAH_ATG_gDNA_FAM Set 1, probe

<400>  104
agatgaaagc aactgaacat cgactacga                                         29


<210>  105
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40_FAM Set 1, primer F

<400>  105
gcaatagcat cacaaatttc ac                                                22


<210>  106
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40_FAM Set 1, primer R

<400>  106
gatccagaca tgataagata cattg                                             25


<210>  107
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40_FAM Set 1, probe

<400>  107
tcactgcatt ctagttgtgg tttgtcca                                          28


<210>  108
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mPah_1C_LHA_FAM Set 3, primer F

<400>  108
gcaagctcca gatcaccaat a                                                 21


<210>  109
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mPah_1C_LHA_FAM Set 3, primer R

<400>  109
ctgagcaatg cattcagcaa taa                                               23


<210>  110
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mPah_1C_LHA_FAM Set 3, probe

<400>  110
ccctgaacat cccttgacag agca                                              24


<210>  111
<211>  800
<212>  DNA
<213>  Mus musculus

<400>  111
agcattagct tccatttatg cagtgtaaat ggtgagaaca gccccgactg aatacccaga       60

gcatcatctc gtctgtgtca ttcatgcaca taacatatct cagcgaggtg gcccttctgt      120

cctctttgca gagacccagc caccatacta gtacctagag aactggctgg atttcagccc      180

cgatacctcc gggcttttgc tcatgttcgc ctcatagggt catctgggtg gttgcctaag      240

gaaaagtatg tcatggagac taacttgctt ggcattgaat aaaaggtgag ttgagagtgg      300

agcgtgttta aattgcaatc ctgcctctat ttctgtgctt gcagggaaca gtcatcctta      360

attgctatcc tccatcatca tcatgattat ttctggtttt tctctggttg cggagaatcc      420

atactccagg tattccaatg tctcagcatt gccaggcctg tctgagcgtc aggatgtagg      480

tagtctgggc tctctgcctt ctattcttgt ccaggatact ctgccaaaag aatcatgttg      540

tggctgccac ccctcccaca aagcctcccg cttgggtcag tccaggactg gagttgggta      600

tggactgttc atgtctatcc actgctacgt cagggcaaca cccactgaga gtgaccttgt      660

agactgcagt gggagacacc cttcaaaacc tctcctctcc tgtcctgaga gccaggttaa      720

aaccatcagc cccgcatcct gagtgcaaac ttttcctaac cctgctgcta agctagacac      780

ctcacttact gagagccagc                                                  800


<210>  112
<211>  800
<212>  DNA
<213>  Mus musculus

<400>  112
gcagctgttg tcctggagaa cggagtcctg agcagaaaac tctcagactt tgggcaggta       60

agcctgttgg gcttccactg ctaggagaga attggttccc cacatgtgaa agcagtctgg      120

gaaatgctgg tatttccagt ctcctaaggc tactaagaaa tatgacttta tttagaggcg      180

aggaaaatgc ccaggaagtc aactgatgag actagtctta acaagttgag gatacagaaa      240

gttggggatc tgagctgcta ccaacatctg tgtgtctttg ggtggctcat tggtatcctc      300

tgcctattgg ctttatcttc tgtacactga aaggaaatgg ctggtcctta gtcacctggg      360

gtgggagtcc ctatctctcc agggatactt attcaatcct ttcttctggg tatcaaaatg      420

acaagcttgt aagaaactgt cctctttcgg ctttcaggag gtgatgtcgc atgaagagaa      480

tttggggggg gggacttact cagaaccaag gagggagaaa ttaaacagag agggaaatga      540

acaggagtta gcccggagcc tgaagcacct tggggattat gctgggggtg gagggaatcc      600

attgtcctcc ctagggaggg cttgcagaac atgttctttt ctgtgatatt tgtactttcc      660

ccagattgca aatcatggtt tgtacactga gattcagtct ctggaggtaa tatgcctttt      720

ctagcttttc cttggacagg actaaggggt tgagggttgc ctggagtcag agaaatttgt      780

gttaaagaag gttgatatga                                                  800


<210>  113
<211>  3227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  006 vector correction genome

<400>  113
agcattagct tccatttatg cagtgtaaat ggtgagaaca gccccgactg aatacccaga       60

gcatcatctc gtctgtgtca ttcatgcaca taacatatct cagcgaggtg gcccttctgt      120

cctctttgca gagacccagc caccatacta gtacctagag aactggctgg atttcagccc      180

cgatacctcc gggcttttgc tcatgttcgc ctcatagggt catctgggtg gttgcctaag      240

gaaaagtatg tcatggagac taacttgctt ggcattgaat aaaaggtgag ttgagagtgg      300

agcgtgttta aattgcaatc ctgcctctat ttctgtgctt gcagggaaca gtcatcctta      360

attgctatcc tccatcatca tcatgattat ttctggtttt tctctggttg cggagaatcc      420

atactccagg tattccaatg tctcagcatt gccaggcctg tctgagcgtc aggatgtagg      480

tagtctgggc tctctgcctt ctattcttgt ccaggatact ctgccaaaag aatcatgttg      540

tggctgccac ccctcccaca aagcctcccg cttgggtcag tccaggactg gagttgggta      600

tggactgttc atgtctatcc actgctacgt cagggcaaca cccactgaga gtgaccttgt      660

agactgcagt gggagacacc cttcaaaacc tctcctctcc tgtcctgaga gccaggttaa      720

aaccatcagc cccgcatcct gagtgcaaac ttttcctaac cctgctgcta agctagacac      780

ctcacttact gagagccagc atgtccaccg ctgtgctgga gaaccctggg ctggggagga      840

aactgtcaga cttcgggcag gagacttcat acattgagga taactgtaac cagaatggcg      900

ccatctctct gatcttcagc ctgaaggagg aagtgggcgc cctggcaaag gtgctgcgcc      960

tgtttgagga gaacgacgtg aatctgaccc acatcgagtc ccggccttct agactgaaga     1020

aggacgagta cgagttcttt acccacctgg ataagcggtc cctgccagcc ctgacaaaca     1080

tcatcaagat cctgaggcac gacatcggag caaccgtgca cgagctgtct cgggacaaga     1140

agaaggatac cgtgccctgg ttccctcgga caatccagga gctggataga tttgccaacc     1200

agatcctgtc ttacggagca gagctggacg cagatcaccc tggcttcaag gacccagtgt     1260

atcgggcccg gagaaagcag tttgccgata tcgcctacaa ttataggcac ggacagccaa     1320

tccctcgcgt ggagtatatg gaggaggaga agaagacctg gggcacagtg ttcaagaccc     1380

tgaagagcct gtacaagaca cacgcctgct acgagtataa ccacatcttc cccctgctgg     1440

agaagtattg tggctttcac gaggacaata tccctcagct ggaggacgtg agccagttcc     1500

tgcagacctg cacaggcttt aggctgaggc cagtggcagg actgctgagc tcccgggact     1560

tcctgggagg actggccttc agagtgtttc actgcaccca gtacatcagg cacggctcca     1620

agccaatgta tacaccagag cccgacatct gtcacgagct gctgggccac gtgcccctgt     1680

ttagcgatag atccttcgcc cagttttccc aggagatcgg actggcatct ctgggagcac     1740

ctgacgagta catcgagaag ctggccacca tctattggtt cacagtggag tttggcctgt     1800

gcaagcaggg cgatagcatc aaggcctacg gagcaggact gctgtctagc ttcggcgagc     1860

tgcagtattg tctgtccgag aagccaaagc tgctgcccct ggagctggag aagaccgcca     1920

tccagaacta caccgtgaca gagttccagc ccctgtacta tgtggccgag tcttttaacg     1980

atgccaagga gaaggtgaga aatttcgccg ccacaatccc taggcccttc agcgtgcggt     2040

acgaccctta tacccagagg atcgaggtgc tggataatac acagcagctg aagatcctgg     2100

ctgactcaat caatagcgaa atcggaatcc tgtgctccgc cctgcagaaa atcaaatgag     2160

aattcaaggc ctctcgagcc tctagaacta tagtgagtcg tattacgtag atccagacat     2220

gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt     2280

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca     2340

agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt     2400

tttttaagct ttacgtacga tcgtcgagca gctgttgtcc tggagaacgg agtcctgagc     2460

agaaaactct cagactttgg gcaggtaagc ctgttgggct tccactgcta ggagagaatt     2520

ggttccccac atgtgaaagc agtctgggaa atgctggtat ttccagtctc ctaaggctac     2580

taagaaatat gactttattt agaggcgagg aaaatgccca ggaagtcaac tgatgagact     2640

agtcttaaca agttgaggat acagaaagtt ggggatctga gctgctacca acatctgtgt     2700

gtctttgggt ggctcattgg tatcctctgc ctattggctt tatcttctgt acactgaaag     2760

gaaatggctg gtccttagtc acctggggtg ggagtcccta tctctccagg gatacttatt     2820

caatcctttc ttctgggtat caaaatgaca agcttgtaag aaactgtcct ctttcggctt     2880

tcaggaggtg atgtcgcatg aagagaattt gggggggggg acttactcag aaccaaggag     2940

ggagaaatta aacagagagg gaaatgaaca ggagttagcc cggagcctga agcaccttgg     3000

ggattatgct gggggtggag ggaatccatt gtcctcccta gggagggctt gcagaacatg     3060

ttcttttctg tgatatttgt actttcccca gattgcaaat catggtttgt acactgagat     3120

tcagtctctg gaggtaatat gccttttcta gcttttcctt ggacaggact aaggggttga     3180

gggttgcctg gagtcagaga aatttgtgtt aaagaaggtt gatatga                   3227


<210>  114
<211>  3635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  006 vector correction genome (+ ITRs)

<400>  114
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgca gcattagctt ccatttatgc agtgtaaatg      240

gtgagaacag ccccgactga atacccagag catcatctcg tctgtgtcat tcatgcacat      300

aacatatctc agcgaggtgg cccttctgtc ctctttgcag agacccagcc accatactag      360

tacctagaga actggctgga tttcagcccc gatacctccg ggcttttgct catgttcgcc      420

tcatagggtc atctgggtgg ttgcctaagg aaaagtatgt catggagact aacttgcttg      480

gcattgaata aaaggtgagt tgagagtgga gcgtgtttaa attgcaatcc tgcctctatt      540

tctgtgcttg cagggaacag tcatccttaa ttgctatcct ccatcatcat catgattatt      600

tctggttttt ctctggttgc ggagaatcca tactccaggt attccaatgt ctcagcattg      660

ccaggcctgt ctgagcgtca ggatgtaggt agtctgggct ctctgccttc tattcttgtc      720

caggatactc tgccaaaaga atcatgttgt ggctgccacc cctcccacaa agcctcccgc      780

ttgggtcagt ccaggactgg agttgggtat ggactgttca tgtctatcca ctgctacgtc      840

agggcaacac ccactgagag tgaccttgta gactgcagtg ggagacaccc ttcaaaacct      900

ctcctctcct gtcctgagag ccaggttaaa accatcagcc ccgcatcctg agtgcaaact      960

tttcctaacc ctgctgctaa gctagacacc tcacttactg agagccagca tgtccaccgc     1020

tgtgctggag aaccctgggc tggggaggaa actgtcagac ttcgggcagg agacttcata     1080

cattgaggat aactgtaacc agaatggcgc catctctctg atcttcagcc tgaaggagga     1140

agtgggcgcc ctggcaaagg tgctgcgcct gtttgaggag aacgacgtga atctgaccca     1200

catcgagtcc cggccttcta gactgaagaa ggacgagtac gagttcttta cccacctgga     1260

taagcggtcc ctgccagccc tgacaaacat catcaagatc ctgaggcacg acatcggagc     1320

aaccgtgcac gagctgtctc gggacaagaa gaaggatacc gtgccctggt tccctcggac     1380

aatccaggag ctggatagat ttgccaacca gatcctgtct tacggagcag agctggacgc     1440

agatcaccct ggcttcaagg acccagtgta tcgggcccgg agaaagcagt ttgccgatat     1500

cgcctacaat tataggcacg gacagccaat ccctcgcgtg gagtatatgg aggaggagaa     1560

gaagacctgg ggcacagtgt tcaagaccct gaagagcctg tacaagacac acgcctgcta     1620

cgagtataac cacatcttcc ccctgctgga gaagtattgt ggctttcacg aggacaatat     1680

ccctcagctg gaggacgtga gccagttcct gcagacctgc acaggcttta ggctgaggcc     1740

agtggcagga ctgctgagct cccgggactt cctgggagga ctggccttca gagtgtttca     1800

ctgcacccag tacatcaggc acggctccaa gccaatgtat acaccagagc ccgacatctg     1860

tcacgagctg ctgggccacg tgcccctgtt tagcgataga tccttcgccc agttttccca     1920

ggagatcgga ctggcatctc tgggagcacc tgacgagtac atcgagaagc tggccaccat     1980

ctattggttc acagtggagt ttggcctgtg caagcagggc gatagcatca aggcctacgg     2040

agcaggactg ctgtctagct tcggcgagct gcagtattgt ctgtccgaga agccaaagct     2100

gctgcccctg gagctggaga agaccgccat ccagaactac accgtgacag agttccagcc     2160

cctgtactat gtggccgagt cttttaacga tgccaaggag aaggtgagaa atttcgccgc     2220

cacaatccct aggcccttca gcgtgcggta cgacccttat acccagagga tcgaggtgct     2280

ggataataca cagcagctga agatcctggc tgactcaatc aatagcgaaa tcggaatcct     2340

gtgctccgcc ctgcagaaaa tcaaatgaga attcaaggcc tctcgagcct ctagaactat     2400

agtgagtcgt attacgtaga tccagacatg ataagataca ttgatgagtt tggacaaacc     2460

acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta     2520

tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg     2580

tttcaggttc agggggaggt gtgggaggtt ttttaagctt tacgtacgat cgtcgagcag     2640

ctgttgtcct ggagaacgga gtcctgagca gaaaactctc agactttggg caggtaagcc     2700

tgttgggctt ccactgctag gagagaattg gttccccaca tgtgaaagca gtctgggaaa     2760

tgctggtatt tccagtctcc taaggctact aagaaatatg actttattta gaggcgagga     2820

aaatgcccag gaagtcaact gatgagacta gtcttaacaa gttgaggata cagaaagttg     2880

gggatctgag ctgctaccaa catctgtgtg tctttgggtg gctcattggt atcctctgcc     2940

tattggcttt atcttctgta cactgaaagg aaatggctgg tccttagtca cctggggtgg     3000

gagtccctat ctctccaggg atacttattc aatcctttct tctgggtatc aaaatgacaa     3060

gcttgtaaga aactgtcctc tttcggcttt caggaggtga tgtcgcatga agagaatttg     3120

ggggggggga cttactcaga accaaggagg gagaaattaa acagagaggg aaatgaacag     3180

gagttagccc ggagcctgaa gcaccttggg gattatgctg ggggtggagg gaatccattg     3240

tcctccctag ggagggcttg cagaacatgt tcttttctgt gatatttgta ctttccccag     3300

attgcaaatc atggtttgta cactgagatt cagtctctgg aggtaatatg ccttttctag     3360

cttttccttg gacaggacta aggggttgag ggttgcctgg agtcagagaa atttgtgtta     3420

aagaaggttg atatgacctg caggtctaga tacgtagata agtagcatgg cgggttaatc     3480

attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     3540

ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca     3600

gtgagcgagc gagcgcgcag agagggagtg gccaa                                3635


<210>  115
<211>  960
<212>  DNA
<213>  Homo sapiens

<400>  115
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatctga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960


<210>  116
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Silently altered PAH coding sequence

<400>  116
tccaccgctg tgctggagaa ccctgggctg gggaggaaac tgtcagactt cgggcaggag       60

acttcataca ttgaggataa ctgtaaccag aatggcgcca tctctctgat cttcagcctg      120

aaggaggaag tgggcgccct ggcaaaggtg ctgcgcctgt ttgaggagaa cgacgtgaat      180

ctgacccaca tcgagtcccg gccttctaga ctgaagaagg acgagtacga gttctttacc      240

cacctggata agcggtccct gccagccctg acaaacatca tcaagatcct gaggcacgac      300

atcggagcaa ccgtgcacga gctgtctcgg gacaagaaga aggataccgt gccctggttc      360

cctcggacaa tccaggagct ggatagattt gccaaccaga tcctgtctta cggagcagag      420

ctggacgcag atcaccctgg cttcaaggac ccagtgtatc gggcccggag aaagcagttt      480

gccgatatcg cctacaatta taggcacgga cagccaatcc ctcgcgtgga gtatatggag      540

gaggagaaga agacctgggg cacagtgttc aagaccctga agagcctgta caagacacac      600

gcctgctacg agtataacca catcttcccc ctgctggaga agtattgtgg ctttcacgag      660

gacaatatcc ctcagctgga ggacgtgagc cagttcctgc agacctgcac aggctttagg      720

ctgaggccag tggcaggact gctgagctcc cgggacttcc tgggaggact ggccttcaga      780

gtgtttcact gcacccagta catcaggcac ggctccaagc caatgtatac accagagccc      840

gacatctgtc acgagctgct gggccacgtg cccctgttta gcgatagatc cttcgcccag      900

ttttcccagg agatcggact ggcatctctg ggagcacctg acgagtacat cgagaagctg      960

gccaccatct attggttcac agtggagttt ggcctgtgca agcagggcga tagcatcaag     1020

gcctacggag caggactgct gtctagcttc ggcgagctgc agtattgtct gtccgagaag     1080

ccaaagctgc tgcccctgga gctggagaag accgccatcc agaactacac cgtgacagag     1140

ttccagcccc tgtactatgt ggccgagtct tttaacgatg ccaaggagaa ggtgagaaat     1200

ttcgccgcca caatccctag gcccttcagc gtgcggtacg acccttatac ccagaggatc     1260

gaggtgctgg ataatacaca gcagctgaag atcctggctg actcaatcaa tagcgaaatc     1320

ggaatcctgt gctccgccct gcagaaaatc aaa                                  1353


<210>  117
<211>  910
<212>  DNA
<213>  Homo sapiens

<400>  117
ctgggatggg atgtggaatc cttctagatt tcttttgtaa tatttataaa gtgctctcag       60

caaggtatca aaatggcaaa attgtgagta actatcctcc tttcattttg ggaagaagat      120

gaggcatgaa gagaattcag acagaaactt actcagacca ggggaggcag aaactaagca      180

gagaggaaaa tgaccaagag ttagccctgg gcatggaatg tgaaagaacc ctaaacgtga      240

cttggaaata atgcccaagg tatattccat tctccgggat ttgttggcat tttcttgagg      300

tgaagaattg cagaatacat tctttaatgt gacctacata tttacccatg ggaggaagtc      360

tgctcctgga ctcttgagat tcagtcataa agcccaggcc agggaaataa tgtaagtctg      420

caggcccctg tcatcagtag gattagggag aagagttctc agtagaaaac agggaggctg      480

gagagaaaag aatggttaat gttaacgtta atataactag aaagactgca gaacttagga      540

ctgattttta tttgaatcct taaaaaaaaa atttcttatg aaaatagtac atggctctta      600

ggagacagaa cttattgtac agaggaacag cgtgagagtc agagtgatcc cagaacaggt      660

cctggctcca tcctgcacat agttttggtg ctgctggcaa tacggtcccc acaactgtgg      720

gaaggggtta ggggcaggga tctcatcagg aaagcatagg ggtttaaagt tctttataga      780

gcacttagaa gattgagaat ccacaaatta tattaataac aaacaaagta gtgtcgtgtt      840

atatagtaaa tgtgaatttg cagacacatt tagggaaaag ttataattaa aaaaataggc      900

tgtatatata                                                             910


<210>  118
<211>  3713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  032 correction vector genome

<400>  118
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatctga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960

aagcttctga cctcttctct tcctcccaca gggcggtacc agatctggca gcggagaggg     1020

cagaggaagt cttctaacat gcggtgacgt ggaggagaat cccggcccta ggggtacctc     1080

caccgctgtg ctggagaacc ctgggctggg gaggaaactg tcagacttcg ggcaggagac     1140

ttcatacatt gaggataact gtaaccagaa tggcgccatc tctctgatct tcagcctgaa     1200

ggaggaagtg ggcgccctgg caaaggtgct gcgcctgttt gaggagaacg acgtgaatct     1260

gacccacatc gagtcccggc cttctagact gaagaaggac gagtacgagt tctttaccca     1320

cctggataag cggtccctgc cagccctgac aaacatcatc aagatcctga ggcacgacat     1380

cggagcaacc gtgcacgagc tgtctcggga caagaagaag gataccgtgc cctggttccc     1440

tcggacaatc caggagctgg atagatttgc caaccagatc ctgtcttacg gagcagagct     1500

ggacgcagat caccctggct tcaaggaccc agtgtatcgg gcccggagaa agcagtttgc     1560

cgatatcgcc tacaattata ggcacggaca gccaatccct cgcgtggagt atatggagga     1620

ggagaagaag acctggggca cagtgttcaa gaccctgaag agcctgtaca agacacacgc     1680

ctgctacgag tataaccaca tcttccccct gctggagaag tattgtggct ttcacgagga     1740

caatatccct cagctggagg acgtgagcca gttcctgcag acctgcacag gctttaggct     1800

gaggccagtg gcaggactgc tgagctcccg ggacttcctg ggaggactgg ccttcagagt     1860

gtttcactgc acccagtaca tcaggcacgg ctccaagcca atgtatacac cagagcccga     1920

catctgtcac gagctgctgg gccacgtgcc cctgtttagc gatagatcct tcgcccagtt     1980

ttcccaggag atcggactgg catctctggg agcacctgac gagtacatcg agaagctggc     2040

caccatctat tggttcacag tggagtttgg cctgtgcaag cagggcgata gcatcaaggc     2100

ctacggagca ggactgctgt ctagcttcgg cgagctgcag tattgtctgt ccgagaagcc     2160

aaagctgctg cccctggagc tggagaagac cgccatccag aactacaccg tgacagagtt     2220

ccagcccctg tactatgtgg ccgagtcttt taacgatgcc aaggagaagg tgagaaattt     2280

cgccgccaca atccctaggc ccttcagcgt gcggtacgac ccttataccc agaggatcga     2340

ggtgctggat aatacacagc agctgaagat cctggctgac tcaatcaata gcgaaatcgg     2400

aatcctgtgc tccgccctgc agaaaatcaa aggtaagcct atccctaacc ctctcctcgg     2460

tctcgattct acgtgatctt gtggaaagga cgaaacaccg gggaattcaa ggcctctcga     2520

gcctctagaa tccccgagac gtttcgtctc gggatcacta tagtgagtcg tattacgtac     2580

acagtgcagg ggaaagaata gtagagatcc agacatgata agatacattg atgagtttgg     2640

acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat     2700

tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca     2760

ttttatgttt caggttcagg gggaggtgtg ggaggttttt taactgggat gggatgtgga     2820

atccttctag atttcttttg taatatttat aaagtgctct cagcaaggta tcaaaatggc     2880

aaaattgtga gtaactatcc tcctttcatt ttgggaagaa gatgaggcat gaagagaatt     2940

cagacagaaa cttactcaga ccaggggagg cagaaactaa gcagagagga aaatgaccaa     3000

gagttagccc tgggcatgga atgtgaaaga accctaaacg tgacttggaa ataatgccca     3060

aggtatattc cattctccgg gatttgttgg cattttcttg aggtgaagaa ttgcagaata     3120

cattctttaa tgtgacctac atatttaccc atgggaggaa gtctgctcct ggactcttga     3180

gattcagtca taaagcccag gccagggaaa taatgtaagt ctgcaggccc ctgtcatcag     3240

taggattagg gagaagagtt ctcagtagaa aacagggagg ctggagagaa aagaatggtt     3300

aatgttaacg ttaatataac tagaaagact gcagaactta ggactgattt ttatttgaat     3360

ccttaaaaaa aaaatttctt atgaaaatag tacatggctc ttaggagaca gaacttattg     3420

tacagaggaa cagcgtgaga gtcagagtga tcccagaaca ggtcctggct ccatcctgca     3480

catagttttg gtgctgctgg caatacggtc cccacaactg tgggaagggg ttaggggcag     3540

ggatctcatc aggaaagcat aggggtttaa agttctttat agagcactta gaagattgag     3600

aatccacaaa ttatattaat aacaaacaaa gtagtgtcgt gttatatagt aaatgtgaat     3660

ttgcagacac atttagggaa aagttataat taaaaaaata ggctgtatat ata            3713


<210>  119
<211>  4139
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  032 vector correction genome (+ ITRs)

<400>  119
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgct tcaggagcag ttgtgcgaat agctggagaa      240

caccaggctg gatttaaacc cagatcgctc ttacatttgc tctttacctg ctgtgctcag      300

cgttcacgtg ccctctagct gtagttttct gaagtcagcg cacagcaagg cagtgtgctt      360

agaggttaac agaagggaaa acaacaacaa caaaaatcta aatgagaatc ctgactgttt      420

cagctggggg taaggggggc ggattattca tataattgtt ataccagacg gtcgcaggct      480

tagtccaatt gcagagaact cgcttcccag gcttctgaga gtcccggaag tgcctaaacc      540

tgtctaatcg acggggcttg ggtggcccgt cgctccctgg cttcttccct ttacccaggg      600

cgggcagcga agtggtgcct cctgcgtccc ccacaccctc cctcagcccc tcccctccgg      660

cccgtcctgg gcaggtgacc tggagcatcc ggcaggctgc cctggcctcc tgcgtcagga      720

caacgcccac gaggggcgtt actgtgcgga gatgcaccac gcaagagaca ccctttgtaa      780

ctctcttctc ctccctagtg cgaggttaaa accttcagcc ccacgtgctg tttgcaaacc      840

tgcctgtacc tgaggcccta aaaagccaga gacctcactc ccggggagcc agcatgtcca      900

ctgcggtcct ggaaaaccca ggcttgggca ggaaactctc tgactttgga caggtgagcc      960

acggcagcct gagctgctca gttaggggaa tttgggcctc cagagaaaga gatctgaaga     1020

ctgctggtgc ttcctggttt cataagctca gtaagaagtc tgaattcgtt ggaagctgat     1080

gagaatatcc aggaagtcaa cagacaaatg tcctcaacaa ttgtttctaa gtaggagaac     1140

atctgtcctc ggtggctttc acaggaaaag cttctgacct cttctcttcc tcccacaggg     1200

cggtaccaga tctggcagcg gagagggcag aggaagtctt ctaacatgcg gtgacgtgga     1260

ggagaatccc ggccctaggg gtacctccac cgctgtgctg gagaaccctg ggctggggag     1320

gaaactgtca gacttcgggc aggagacttc atacattgag gataactgta accagaatgg     1380

cgccatctct ctgatcttca gcctgaagga ggaagtgggc gccctggcaa aggtgctgcg     1440

cctgtttgag gagaacgacg tgaatctgac ccacatcgag tcccggcctt ctagactgaa     1500

gaaggacgag tacgagttct ttacccacct ggataagcgg tccctgccag ccctgacaaa     1560

catcatcaag atcctgaggc acgacatcgg agcaaccgtg cacgagctgt ctcgggacaa     1620

gaagaaggat accgtgccct ggttccctcg gacaatccag gagctggata gatttgccaa     1680

ccagatcctg tcttacggag cagagctgga cgcagatcac cctggcttca aggacccagt     1740

gtatcgggcc cggagaaagc agtttgccga tatcgcctac aattataggc acggacagcc     1800

aatccctcgc gtggagtata tggaggagga gaagaagacc tggggcacag tgttcaagac     1860

cctgaagagc ctgtacaaga cacacgcctg ctacgagtat aaccacatct tccccctgct     1920

ggagaagtat tgtggctttc acgaggacaa tatccctcag ctggaggacg tgagccagtt     1980

cctgcagacc tgcacaggct ttaggctgag gccagtggca ggactgctga gctcccggga     2040

cttcctggga ggactggcct tcagagtgtt tcactgcacc cagtacatca ggcacggctc     2100

caagccaatg tatacaccag agcccgacat ctgtcacgag ctgctgggcc acgtgcccct     2160

gtttagcgat agatccttcg cccagttttc ccaggagatc ggactggcat ctctgggagc     2220

acctgacgag tacatcgaga agctggccac catctattgg ttcacagtgg agtttggcct     2280

gtgcaagcag ggcgatagca tcaaggccta cggagcagga ctgctgtcta gcttcggcga     2340

gctgcagtat tgtctgtccg agaagccaaa gctgctgccc ctggagctgg agaagaccgc     2400

catccagaac tacaccgtga cagagttcca gcccctgtac tatgtggccg agtcttttaa     2460

cgatgccaag gagaaggtga gaaatttcgc cgccacaatc cctaggccct tcagcgtgcg     2520

gtacgaccct tatacccaga ggatcgaggt gctggataat acacagcagc tgaagatcct     2580

ggctgactca atcaatagcg aaatcggaat cctgtgctcc gccctgcaga aaatcaaagg     2640

taagcctatc cctaaccctc tcctcggtct cgattctacg tgatcttgtg gaaaggacga     2700

aacaccgggg aattcaaggc ctctcgagcc tctagaatcc ccgagacgtt tcgtctcggg     2760

atcactatag tgagtcgtat tacgtacaca gtgcagggga aagaatagta gagatccaga     2820

catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg     2880

ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa     2940

acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga     3000

ggttttttaa ctgggatggg atgtggaatc cttctagatt tcttttgtaa tatttataaa     3060

gtgctctcag caaggtatca aaatggcaaa attgtgagta actatcctcc tttcattttg     3120

ggaagaagat gaggcatgaa gagaattcag acagaaactt actcagacca ggggaggcag     3180

aaactaagca gagaggaaaa tgaccaagag ttagccctgg gcatggaatg tgaaagaacc     3240

ctaaacgtga cttggaaata atgcccaagg tatattccat tctccgggat ttgttggcat     3300

tttcttgagg tgaagaattg cagaatacat tctttaatgt gacctacata tttacccatg     3360

ggaggaagtc tgctcctgga ctcttgagat tcagtcataa agcccaggcc agggaaataa     3420

tgtaagtctg caggcccctg tcatcagtag gattagggag aagagttctc agtagaaaac     3480

agggaggctg gagagaaaag aatggttaat gttaacgtta atataactag aaagactgca     3540

gaacttagga ctgattttta tttgaatcct taaaaaaaaa atttcttatg aaaatagtac     3600

atggctctta ggagacagaa cttattgtac agaggaacag cgtgagagtc agagtgatcc     3660

cagaacaggt cctggctcca tcctgcacat agttttggtg ctgctggcaa tacggtcccc     3720

acaactgtgg gaaggggtta ggggcaggga tctcatcagg aaagcatagg ggtttaaagt     3780

tctttataga gcacttagaa gattgagaat ccacaaatta tattaataac aaacaaagta     3840

gtgtcgtgtt atatagtaaa tgtgaatttg cagacacatt tagggaaaag ttataattaa     3900

aaaaataggc tgtatatata ctagatacgt agataagtag cctgcaggtc tagatacgta     3960

gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc     4020

actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc     4080

ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaa      4139


<210>  120
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chymeric MVM intron (ChiMVM)

<400>  120
gtaagggttt aagggatggt tggttggtgg ggtattaatg tttaattacc tggagcacct       60

gcctgaaatc acctgacctc ttctcttcct cccacag                                97


<210>  121
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 intron

<400>  121
gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa       60

agaactgctc ctcagtggat gttgccttta cttctag                                97


<210>  122
<211>  521
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adenovirus tripartite leader intron (AdTPL)

<400>  122
gtcctcactc tcttccgcat cgctgtctgc gagggccagc tgttgggctc gcggttgagg       60

acaaactctt cgcggtcttt ccagtactct tggatcggaa acccgtcggc ctccgaacgg      120

tactccgcca ccgagggacc tgagcgagtc cgcatcgacc ggatcggaaa acctctcgag      180

aaaggcgtct aaccagtcac agtcgcaagg taggctgagc accgtggcgg gcggcagcgg      240

gtggcggtcg gggttgtttc tggcggaggt gctgctgatg atgtaattaa agtaggcggt      300

cttgagacgg cggatggtcg aggtgaggtg tggcaggctt gagatccagc tgttggggtg      360

agtactccct ctcaaaagcg ggcattactt ctgcgctaag attgtcagtt tccaaaaacg      420

aggaggattt gatattcacc tggcccgatc tggccataca cttgagtgac aatgacatcc      480

actttgcctt tctctccaca ggtgtccact cccaggtcca g                          521


<210>  123
<211>  124
<212>  DNA
<213>  Homo sapiens

<400>  123
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg catgtggaga       60

cagagaagac tcttgggttt ctgataggca ctgactctct tcctttgtcc tgttcccatt      120

tcag                                                                   124


<210>  124
<211>  230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AdV/Ig chimeric intron (AdVIgG)

<400>  124
gtgagtactc cctctcaaaa gcgggcatga cttctgcgct aagattgtca gtttccaaaa       60

acgaggagga tttgatattc acctggcccg cggtgatgcc tttgagggtg gccgcgtcca      120

tctggtcaga aaagacaatc tttttgttgt caagcttgag gtgtggcagg cttgagatct      180

ggccatacac ttgagtgaca atgacatcca ctttgccttt ctctccacag                 230


<210>  125
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta globin Ig heavy chain intron (beta-globinIg)

<400>  125
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  126
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MVM intron

<400>  126
gtaagggttt aagggatggt tggttggtgg ggtattaatg tttaattacc tggagcacct       60

gcctgaaatc actttttttc ag                                                82


<210>  127
<211>  618
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCR1 element (OptHCR)

<400>  127
gtaagtttta tggaatgtga atcataattc aatttttcaa catgcgttag gagggacatt       60

tcaaactctt ttttacccta gactttccta ccatcaccca gagtatccag ccaggagggg      120

aggggctaga gacaccagaa gtttagcagg gaggagggcg tagggattcg gggaatgaag      180

ggatgggatt cagactaggg ccaggaccca gggatggaga gaaagagatg agagtggttt      240

gggggcttgg tgacttagag aacagagctg caggctcaga ggcacacagg agtttctggg      300

ctggcccggc ccccttccaa cccctcatta tggaatccag cagctgtttg tgtgctgcct      360

ctgaagtcca cactgaacaa acttcagcct actcatgtcc catataaggg aaattatgga      420

atcagcaaac agcaaacaca cagccctccc tgcctgctga ccttggacct ggggcagagg      480

tcagagacct ccttggctct atgccacctc caacatccac tcgacccctt ggaatttcgg      540

tggagaggag cagaggttgt cctggcgtgg tttaggtagt gtgagagggc tgaccatgcc      600

ttcttctttt tcctacag                                                    618


<210>  128
<211>  476
<212>  DNA
<213>  Homo sapiens

<400>  128
gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60

cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt      120

tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      180

actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg cctctttgca      240

ccattctaaa gaataacagt gataatttct gggttaaggc aatagcaata tttctgcata      300

taaatatttc tgcatataaa ttgtaactga tgtaagaggt ttcatattgc taatagcagc      360

tacaatccag ctaccattct gcttttattt tatggttggg ataaggctgg attattctga      420

gtccaagcta ggcccttttg ctaatcatgt tcatacctct tatcttcctc ccacag          476


<210>  129
<211>  299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tFIX intron (FIX intron)

<400>  129
gtaagtttcc ttttttaaaa tacattgagt atgcttgcct tttagatata gaaatatctg       60

atgctgtctt cttcactaaa ttttgattac atgatttgac agcaatattg aagagtctaa      120

cagccagcac gcaggttggc aactactgtg ggaacatcac agattttggc tccatgccct      180

aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta      240

aaattttcat gatgttttct tttttgctaa aactaaagaa ttattctttt acatttcag       299


<210>  130
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ch2BLood intron (BloodEnh)

<400>  130
gtaagtagtc tacactgggg ctaagtaaac atttactgag tgaaagaata aatacgtgca       60

gaacccagcc aacagagagc atccccggag gtggggccat gccctcaggc actcagagga      120

ggcaggcctc tggcagtagc taagcagatt cccgtctcag atgtcagccc tgcccaccct      180

tctgtgcccc cccgcccccc tggttggtgt ttgtgggaca gtttccactg tgttgcctgg      240

gaaacgaggc atcctgccac caccactccc cacctccggg ctgccaacac ctaccacgcc      300

cggcttgggg gttttggctg gtttcccttg tgtcctagtc agcttgagaa accctcggat      360

gcactcgcca cttttacagt gtggctttgc tcatctgggt gggaggtact gcctggggtg      420

agctcatcac ctctggttcc tcagtgcaag gcactaaagt ctcttggcac tgagttctta      480

caacttgttc caggggatat ttggtggttg atggtcacca cccatgtgtc atggtccctg      540

agcatccccc gccaccccac tgctccctat tttggcagtt actgtcaccc tctagggatg      600

cagggatgca gtttacctat ctagagtgcg gtgatcaggt ggggaagtac aaatggcaat      660

tgacagctag agagcttgaa accctcccac ttggctctgc tcaccctgga ctctgggaga      720

cctcagctgc ccagcagtgg aggctggggc agcagagggg ccagacctgg gagcccagaa      780

gcctggatct gagtctgact cactgctgac ctttgacccc tggaggcttg ggcaagctga      840

ggaacttctc tggtcttaat cctgtgggtg actgaccatg ccttcttctt tttcctacag      900


<210>  131
<211>  1977
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  006-HCR vector PAH coding sequence

<400>  131
atgtccaccg ctgtgctgga gaaccctggg ctggggagga aactgtcaga cttcgggcag       60

gtaagtttta tggaatgtga atcataattc aatttttcaa catgcgttag gagggacatt      120

tcaaactctt ttttacccta gactttccta ccatcaccca gagtatccag ccaggagggg      180

aggggctaga gacaccagaa gtttagcagg gaggagggcg tagggattcg gggaatgaag      240

ggatgggatt cagactaggg ccaggaccca gggatggaga gaaagagatg agagtggttt      300

gggggcttgg tgacttagag aacagagctg caggctcaga ggcacacagg agtttctggg      360

ctggcccggc ccccttccaa cccctcatta tggaatccag cagctgtttg tgtgctgcct      420

ctgaagtcca cactgaacaa acttcagcct actcatgtcc catataaggg aaattatgga      480

atcagcaaac agcaaacaca cagccctccc tgcctgctga ccttggacct ggggcagagg      540

tcagagacct ccttggctct atgccacctc caacatccac tcgacccctt ggaatttcgg      600

tggagaggag cagaggttgt cctggcgtgg tttaggtagt gtgagagggc tgaccatgcc      660

ttcttctttt tcctacagga aacttcatac attgaggata actgtaacca gaatggcgcc      720

atctctctga tcttcagcct gaaggaggaa gtgggcgccc tggcaaaggt gctgcgcctg      780

tttgaggaga acgacgtgaa tctgacccac atcgagtccc ggccttctag actgaagaag      840

gacgagtacg agttctttac ccacctggat aagcggtccc tgccagccct gacaaacatc      900

atcaagatcc tgaggcacga catcggagca accgtgcacg agctgtctcg ggacaagaag      960

aaggataccg tgccctggtt ccctcggaca atccaggagc tggatagatt tgccaaccag     1020

atcctgtctt acggagcaga gctggacgca gatcaccctg gcttcaagga cccagtgtat     1080

cgggcccgga gaaagcagtt tgccgatatc gcctacaatt ataggcacga acagccaatc     1140

cctcgcgtgg agtatatgga ggaggagaag aagacctggg gcacagtgtt caagaccctg     1200

aagagcctgt acaagacaca cgcctgctac gagtataacc acatcttccc cctgctggag     1260

aagtattgtg gctttcacga ggacaatatc cctcagctgg aggacgtgag ccagttcctg     1320

cagacctgca caggctttag gctgaggcca gtggcaggac tgctgagctc ccgggacttc     1380

ctgggaggac tggccttcag agtgtttcac tgcacccagt acatcaggca cggctccaag     1440

ccaatgtata caccagagcc cgacatctgt cacgagctgc tgggccacgt gcccctgttt     1500

agcgatagat ccttcgccca gttttcccag gagatcggac tggcatctct gggagcacct     1560

gacgagtaca tcgagaagct ggccaccatc tattggttca cagtggagtt tggcctgtgc     1620

aagcagggcg atagcatcaa ggcctacgga gcaggactgc tgtctagctt cggcgagctg     1680

cagtattgtc tgtccgagaa gccaaagctg ctgcccctgg agctggagaa gaccgccatc     1740

cagaactaca ccgtgacaga gttccagccc ctgtactatg tggccgagtc ttttaacgat     1800

gccaaggaga aggtgagaaa tttcgccgcc acaatcccta ggcccttcag cgtgcggtac     1860

gacccttata cccagaggat cgaggtgctg gataatacac agcagctgaa gatcctggct     1920

gactcaatca atagcgaaat cggaatcctg tgctccgccc tgcagaaaat caaatga        1977


<210>  132
<211>  1971
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  032-HCR vector PAH coding sequence

<400>  132
tccaccgctg tgctggagaa ccctgggctg gggaggaaac tgtcagactt cgggcaggta       60

agttttatgg aatgtgaatc ataattcaat ttttcaacat gcgttaggag ggacatttca      120

aactcttttt taccctagac tttcctacca tcacccagag tatccagcca ggaggggagg      180

ggctagagac accagaagtt tagcagggag gagggcgtag ggattcgggg aatgaaggga      240

tgggattcag actagggcca ggacccaggg atggagagaa agagatgaga gtggtttggg      300

ggcttggtga cttagagaac agagctgcag gctcagaggc acacaggagt ttctgggctg      360

gcccggcccc cttccaaccc ctcattatgg aatccagcag ctgtttgtgt gctgcctctg      420

aagtccacac tgaacaaact tcagcctact catgtcccat ataagggaaa ttatggaatc      480

agcaaacagc aaacacacag ccctccctgc ctgctgacct tggacctggg gcagaggtca      540

gagacctcct tggctctatg ccacctccaa catccactcg accccttgga atttcggtgg      600

agaggagcag aggttgtcct ggcgtggttt aggtagtgtg agagggctga ccatgccttc      660

ttctttttcc tacaggaaac ttcatacatt gaggataact gtaaccagaa tggcgccatc      720

tctctgatct tcagcctgaa ggaggaagtg ggcgccctgg caaaggtgct gcgcctgttt      780

gaggagaacg acgtgaatct gacccacatc gagtcccggc cttctagact gaagaaggac      840

gagtacgagt tctttaccca cctggataag cggtccctgc cagccctgac aaacatcatc      900

aagatcctga ggcacgacat cggagcaacc gtgcacgagc tgtctcggga caagaagaag      960

gataccgtgc cctggttccc tcggacaatc caggagctgg atagatttgc caaccagatc     1020

ctgtcttacg gagcagagct ggacgcagat caccctggct tcaaggaccc agtgtatcgg     1080

gcccggagaa agcagtttgc cgatatcgcc tacaattata ggcacggaca gccaatccct     1140

cgcgtggagt atatggagga ggagaagaag acctggggca cagtgttcaa gaccctgaag     1200

agcctgtaca agacacacgc ctgctacgag tataaccaca tcttccccct gctggagaag     1260

tattgtggct ttcacgagga caatatccct cagctggagg acgtgagcca gttcctgcag     1320

acctgcacag gctttaggct gaggccagtg gcaggactgc tgagctcccg ggacttcctg     1380

ggaggactgg ccttcagagt gtttcactgc acccagtaca tcaggcacgg ctccaagcca     1440

atgtatacac cagagcccga catctgtcac gagctgctgg gccacgtgcc cctgtttagc     1500

gatagatcct tcgcccagtt ttcccaggag atcggactgg catctctggg agcacctgac     1560

gagtacatcg agaagctggc caccatctat tggttcacag tggagtttgg cctgtgcaag     1620

cagggcgata gcatcaaggc ctacggagca ggactgctgt ctagcttcgg cgagctgcag     1680

tattgtctgt ccgagaagcc aaagctgctg cccctggagc tggagaagac cgccatccag     1740

aactacaccg tgacagagtt ccagcccctg tactatgtgg ccgagtcttt taacgatgcc     1800

aaggagaagg tgagaaattt cgccgccaca atccctaggc ccttcagcgt gcggtacgac     1860

ccttataccc agaggatcga ggtgctggat aatacacagc agctgaagat cctggctgac     1920

tcaatcaata gcgaaatcgg aatcctgtgc tccgccctgc agaaaatcaa a              1971


<210>  133
<211>  174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ID cassette

<400>  133
ggtaagccta tccctaaccc tctcctcggt ctcgattcta cgtgatcttg tggaaaggac       60

gaaacaccgg ggaattcaag gcctctcgag cctctagaat ccccgagacg tttcgtctcg      120

ggatcactat agtgagtcgt attacgtaca cagtgcaggg gaaagaatag taga            174


<210>  134
<211>  800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  006-HCR vector correction genome

<400>  134
gcagctgttg tcctggagaa cggagtcctg agcagaaaac tctcagactt tgggcaggta       60

agcctgttgg gcttccactg ctaggagaga attggttccc cacatgtgaa agcagtctgg      120

gaaatgctgg tatttccagt ctcctaaggc tactaagaaa tatgacttta tttagaggcg      180

aggaaaatgc ccaggaagtc aactgatgag actagtctta acaagttgag gatacagaaa      240

gttggggatc tgagctgcta ccaacatctg tgtgtctttg ggtggctcat tggtatcctc      300

tgcctattgg ctttatcttc tgtacactga aaggaaatgg ctggtcctta gtcacctggg      360

gtgggagtcc ctatctctcc agggatactt attcaatcct ttcttctggg tatcaaaatg      420

acaagcttgt aagaaactgt cctctttcgg ctttcaggag gtgatgtcgc atgaagagaa      480

tttggggggg gggacttact cagaaccaag gagggagaaa ttaaacagag agggaaatga      540

acaggagtta gcccggagcc tgaagcacct tggggattat gctgggggtg gagggaatcc      600

attgtcctcc ctagggaggg cttgcagaac atgttctttt ctgtgatatt tgtactttcc      660

ccagattgca aatcatggtt tgtacactga gattcagtct ctggaggtaa tatgcctttt      720

ctagcttttc cttggacagg actaaggggt tgagggttgc ctggagtcag agaaatttgt      780

gttaaagaag gttgatatga                                                  800


<210>  135
<211>  4253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  006-HCR vector correction genome (+ITRs)

<400>  135
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgca gcattagctt ccatttatgc agtgtaaatg      240

gtgagaacag ccccgactga atacccagag catcatctcg tctgtgtcat tcatgcacat      300

aacatatctc agcgaggtgg cccttctgtc ctctttgcag agacccagcc accatactag      360

tacctagaga actggctgga tttcagcccc gatacctccg ggcttttgct catgttcgcc      420

tcatagggtc atctgggtgg ttgcctaagg aaaagtatgt catggagact aacttgcttg      480

gcattgaata aaaggtgagt tgagagtgga gcgtgtttaa attgcaatcc tgcctctatt      540

tctgtgcttg cagggaacag tcatccttaa ttgctatcct ccatcatcat catgattatt      600

tctggttttt ctctggttgc ggagaatcca tactccaggt attccaatgt ctcagcattg      660

ccaggcctgt ctgagcgtca ggatgtaggt agtctgggct ctctgccttc tattcttgtc      720

caggatactc tgccaaaaga atcatgttgt ggctgccacc cctcccacaa agcctcccgc      780

ttgggtcagt ccaggactgg agttgggtat ggactgttca tgtctatcca ctgctacgtc      840

agggcaacac ccactgagag tgaccttgta gactgcagtg ggagacaccc ttcaaaacct      900

ctcctctcct gtcctgagag ccaggttaaa accatcagcc ccgcatcctg agtgcaaact      960

tttcctaacc ctgctgctaa gctagacacc tcacttactg agagccagca tgtccaccgc     1020

tgtgctggag aaccctgggc tggggaggaa actgtcagac ttcgggcagg taagttttat     1080

ggaatgtgaa tcataattca atttttcaac atgcgttagg agggacattt caaactcttt     1140

tttaccctag actttcctac catcacccag agtatccagc caggagggga ggggctagag     1200

acaccagaag tttagcaggg aggagggcgt agggattcgg ggaatgaagg gatgggattc     1260

agactagggc caggacccag ggatggagag aaagagatga gagtggtttg ggggcttggt     1320

gacttagaga acagagctgc aggctcagag gcacacagga gtttctgggc tggcccggcc     1380

cccttccaac ccctcattat ggaatccagc agctgtttgt gtgctgcctc tgaagtccac     1440

actgaacaaa cttcagccta ctcatgtccc atataaggga aattatggaa tcagcaaaca     1500

gcaaacacac agccctccct gcctgctgac cttggacctg gggcagaggt cagagacctc     1560

cttggctcta tgccacctcc aacatccact cgaccccttg gaatttcggt ggagaggagc     1620

agaggttgtc ctggcgtggt ttaggtagtg tgagagggct gaccatgcct tcttcttttt     1680

cctacaggaa acttcataca ttgaggataa ctgtaaccag aatggcgcca tctctctgat     1740

cttcagcctg aaggaggaag tgggcgccct ggcaaaggtg ctgcgcctgt ttgaggagaa     1800

cgacgtgaat ctgacccaca tcgagtcccg gccttctaga ctgaagaagg acgagtacga     1860

gttctttacc cacctggata agcggtccct gccagccctg acaaacatca tcaagatcct     1920

gaggcacgac atcggagcaa ccgtgcacga gctgtctcgg gacaagaaga aggataccgt     1980

gccctggttc cctcggacaa tccaggagct ggatagattt gccaaccaga tcctgtctta     2040

cggagcagag ctggacgcag atcaccctgg cttcaaggac ccagtgtatc gggcccggag     2100

aaagcagttt gccgatatcg cctacaatta taggcacgaa cagccaatcc ctcgcgtgga     2160

gtatatggag gaggagaaga agacctgggg cacagtgttc aagaccctga agagcctgta     2220

caagacacac gcctgctacg agtataacca catcttcccc ctgctggaga agtattgtgg     2280

ctttcacgag gacaatatcc ctcagctgga ggacgtgagc cagttcctgc agacctgcac     2340

aggctttagg ctgaggccag tggcaggact gctgagctcc cgggacttcc tgggaggact     2400

ggccttcaga gtgtttcact gcacccagta catcaggcac ggctccaagc caatgtatac     2460

accagagccc gacatctgtc acgagctgct gggccacgtg cccctgttta gcgatagatc     2520

cttcgcccag ttttcccagg agatcggact ggcatctctg ggagcacctg acgagtacat     2580

cgagaagctg gccaccatct attggttcac agtggagttt ggcctgtgca agcagggcga     2640

tagcatcaag gcctacggag caggactgct gtctagcttc ggcgagctgc agtattgtct     2700

gtccgagaag ccaaagctgc tgcccctgga gctggagaag accgccatcc agaactacac     2760

cgtgacagag ttccagcccc tgtactatgt ggccgagtct tttaacgatg ccaaggagaa     2820

ggtgagaaat ttcgccgcca caatccctag gcccttcagc gtgcggtacg acccttatac     2880

ccagaggatc gaggtgctgg ataatacaca gcagctgaag atcctggctg actcaatcaa     2940

tagcgaaatc ggaatcctgt gctccgccct gcagaaaatc aaatgagaat tcaaggcctc     3000

tcgagcctct agaactatag tgagtcgtat tacgtagatc cagacatgat aagatacatt     3060

gatgagtttg gacaaaccac aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt     3120

tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac     3180

aattgcattc attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaagcttta     3240

cgtacgatcg tcgagcagct gttgtcctgg agaacggagt cctgagcaga aaactctcag     3300

actttgggca ggtaagcctg ttgggcttcc actgctagga gagaattggt tccccacatg     3360

tgaaagcagt ctgggaaatg ctggtatttc cagtctccta aggctactaa gaaatatgac     3420

tttatttaga ggcgaggaaa atgcccagga agtcaactga tgagactagt cttaacaagt     3480

tgaggataca gaaagttggg gatctgagct gctaccaaca tctgtgtgtc tttgggtggc     3540

tcattggtat cctctgccta ttggctttat cttctgtaca ctgaaaggaa atggctggtc     3600

cttagtcacc tggggtggga gtccctatct ctccagggat acttattcaa tcctttcttc     3660

tgggtatcaa aatgacaagc ttgtaagaaa ctgtcctctt tcggctttca ggaggtgatg     3720

tcgcatgaag agaatttggg gggggggact tactcagaac caaggaggga gaaattaaac     3780

agagagggaa atgaacagga gttagcccgg agcctgaagc accttgggga ttatgctggg     3840

ggtggaggga atccattgtc ctccctaggg agggcttgca gaacatgttc ttttctgtga     3900

tatttgtact ttccccagat tgcaaatcat ggtttgtaca ctgagattca gtctctggag     3960

gtaatatgcc ttttctagct tttccttgga caggactaag gggttgaggg ttgcctggag     4020

tcagagaaat ttgtgttaaa gaaggttgat atgacctgca ggtctagata cgtagataag     4080

tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc     4140

tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc     4200

tttgcccggg cggcctcagt gagcgagcga gcgcgcagag agggagtggc caa            4253


<210>  136
<211>  4331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  032-HCR vector correction genome

<400>  136
gcttcaggag cagttgtgcg aatagctgga gaacaccagg ctggatttaa acccagatcg       60

ctcttacatt tgctctttac ctgctgtgct cagcgttcac gtgccctcta gctgtagttt      120

tctgaagtca gcgcacagca aggcagtgtg cttagaggtt aacagaaggg aaaacaacaa      180

caacaaaaat ctaaatgaga atcctgactg tttcagctgg gggtaagggg ggcggattat      240

tcatataatt gttataccag acggtcgcag gcttagtcca attgcagaga actcgcttcc      300

caggcttctg agagtcccgg aagtgcctaa acctgtctaa tcgacggggc ttgggtggcc      360

cgtcgctccc tggcttcttc cctttaccca gggcgggcag cgaagtggtg cctcctgcgt      420

cccccacacc ctccctcagc ccctcccctc cggcccgtcc tgggcaggtg acctggagca      480

tccggcaggc tgccctggcc tcctgcgtca ggacaacgcc cacgaggggc gttactgtgc      540

ggagatgcac cacgcaagag acaccctttg taactctctt ctcctcccta gtgcgaggtt      600

aaaaccttca gccccacgtg ctgtttgcaa acctgcctgt acctgaggcc ctaaaaagcc      660

agagacctca ctcccgggga gccagcatgt ccactgcggt cctggaaaac ccaggcttgg      720

gcaggaaact ctctgacttt ggacaggtga gccacggcag cctgagctgc tcagttaggg      780

gaatttgggc ctccagagaa agagatctga agactgctgg tgcttcctgg tttcataagc      840

tcagtaagaa gtctgaattc gttggaagct gatgagaata tccaggaagt caacagacaa      900

atgtcctcaa caattgtttc taagtaggag aacatctgtc ctcggtggct ttcacaggaa      960

aagcttctga cctcttctct tcctcccaca gggcggtacc agatctggca gcggagaggg     1020

cagaggaagt cttctaacat gcggtgacgt ggaggagaat cccggcccta ggggtacctc     1080

caccgctgtg ctggagaacc ctgggctggg gaggaaactg tcagacttcg ggcaggtaag     1140

ttttatggaa tgtgaatcat aattcaattt ttcaacatgc gttaggaggg acatttcaaa     1200

ctctttttta ccctagactt tcctaccatc acccagagta tccagccagg aggggagggg     1260

ctagagacac cagaagttta gcagggagga gggcgtaggg attcggggaa tgaagggatg     1320

ggattcagac tagggccagg acccagggat ggagagaaag agatgagagt ggtttggggg     1380

cttggtgact tagagaacag agctgcaggc tcagaggcac acaggagttt ctgggctggc     1440

ccggccccct tccaacccct cattatggaa tccagcagct gtttgtgtgc tgcctctgaa     1500

gtccacactg aacaaacttc agcctactca tgtcccatat aagggaaatt atggaatcag     1560

caaacagcaa acacacagcc ctccctgcct gctgaccttg gacctggggc agaggtcaga     1620

gacctccttg gctctatgcc acctccaaca tccactcgac cccttggaat ttcggtggag     1680

aggagcagag gttgtcctgg cgtggtttag gtagtgtgag agggctgacc atgccttctt     1740

ctttttccta caggaaactt catacattga ggataactgt aaccagaatg gcgccatctc     1800

tctgatcttc agcctgaagg aggaagtggg cgccctggca aaggtgctgc gcctgtttga     1860

ggagaacgac gtgaatctga cccacatcga gtcccggcct tctagactga agaaggacga     1920

gtacgagttc tttacccacc tggataagcg gtccctgcca gccctgacaa acatcatcaa     1980

gatcctgagg cacgacatcg gagcaaccgt gcacgagctg tctcgggaca agaagaagga     2040

taccgtgccc tggttccctc ggacaatcca ggagctggat agatttgcca accagatcct     2100

gtcttacgga gcagagctgg acgcagatca ccctggcttc aaggacccag tgtatcgggc     2160

ccggagaaag cagtttgccg atatcgccta caattatagg cacggacagc caatccctcg     2220

cgtggagtat atggaggagg agaagaagac ctggggcaca gtgttcaaga ccctgaagag     2280

cctgtacaag acacacgcct gctacgagta taaccacatc ttccccctgc tggagaagta     2340

ttgtggcttt cacgaggaca atatccctca gctggaggac gtgagccagt tcctgcagac     2400

ctgcacaggc tttaggctga ggccagtggc aggactgctg agctcccggg acttcctggg     2460

aggactggcc ttcagagtgt ttcactgcac ccagtacatc aggcacggct ccaagccaat     2520

gtatacacca gagcccgaca tctgtcacga gctgctgggc cacgtgcccc tgtttagcga     2580

tagatccttc gcccagtttt cccaggagat cggactggca tctctgggag cacctgacga     2640

gtacatcgag aagctggcca ccatctattg gttcacagtg gagtttggcc tgtgcaagca     2700

gggcgatagc atcaaggcct acggagcagg actgctgtct agcttcggcg agctgcagta     2760

ttgtctgtcc gagaagccaa agctgctgcc cctggagctg gagaagaccg ccatccagaa     2820

ctacaccgtg acagagttcc agcccctgta ctatgtggcc gagtctttta acgatgccaa     2880

ggagaaggtg agaaatttcg ccgccacaat ccctaggccc ttcagcgtgc ggtacgaccc     2940

ttatacccag aggatcgagg tgctggataa tacacagcag ctgaagatcc tggctgactc     3000

aatcaatagc gaaatcggaa tcctgtgctc cgccctgcag aaaatcaaag gtaagcctat     3060

ccctaaccct ctcctcggtc tcgattctac gtgatcttgt ggaaaggacg aaacaccggg     3120

gaattcaagg cctctcgagc ctctagaatc cccgagacgt ttcgtctcgg gatcactata     3180

gtgagtcgta ttacgtacac agtgcagggg aaagaatagt agagatccag acatgataag     3240

atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg     3300

tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa     3360

caacaacaat tgcattcatt ttatgtttca ggttcagggg gaggtgtggg aggtttttta     3420

actgggatgg gatgtggaat ccttctagat ttcttttgta atatttataa agtgctctca     3480

gcaaggtatc aaaatggcaa aattgtgagt aactatcctc ctttcatttt gggaagaaga     3540

tgaggcatga agagaattca gacagaaact tactcagacc aggggaggca gaaactaagc     3600

agagaggaaa atgaccaaga gttagccctg ggcatggaat gtgaaagaac cctaaacgtg     3660

acttggaaat aatgcccaag gtatattcca ttctccggga tttgttggca ttttcttgag     3720

gtgaagaatt gcagaataca ttctttaatg tgacctacat atttacccat gggaggaagt     3780

ctgctcctgg actcttgaga ttcagtcata aagcccaggc cagggaaata atgtaagtct     3840

gcaggcccct gtcatcagta ggattaggga gaagagttct cagtagaaaa cagggaggct     3900

ggagagaaaa gaatggttaa tgttaacgtt aatataacta gaaagactgc agaacttagg     3960

actgattttt atttgaatcc ttaaaaaaaa aatttcttat gaaaatagta catggctctt     4020

aggagacaga acttattgta cagaggaaca gcgtgagagt cagagtgatc ccagaacagg     4080

tcctggctcc atcctgcaca tagttttggt gctgctggca atacggtccc cacaactgtg     4140

ggaaggggtt aggggcaggg atctcatcag gaaagcatag gggtttaaag ttctttatag     4200

agcacttaga agattgagaa tccacaaatt atattaataa caaacaaagt agtgtcgtgt     4260

tatatagtaa atgtgaattt gcagacacat ttagggaaaa gttataatta aaaaaatagg     4320

ctgtatatat a                                                          4331


<210>  137
<211>  4737
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  032-HCR vector correction genome (+ ITRs)

<400>  137
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgct tcaggagcag ttgtgcgaat agctggagaa      240

caccaggctg gatttaaacc cagatcgctc ttacatttgc tctttacctg ctgtgctcag      300

cgttcacgtg ccctctagct gtagttttct gaagtcagcg cacagcaagg cagtgtgctt      360

agaggttaac agaagggaaa acaacaacaa caaaaatcta aatgagaatc ctgactgttt      420

cagctggggg taaggggggc ggattattca tataattgtt ataccagacg gtcgcaggct      480

tagtccaatt gcagagaact cgcttcccag gcttctgaga gtcccggaag tgcctaaacc      540

tgtctaatcg acggggcttg ggtggcccgt cgctccctgg cttcttccct ttacccaggg      600

cgggcagcga agtggtgcct cctgcgtccc ccacaccctc cctcagcccc tcccctccgg      660

cccgtcctgg gcaggtgacc tggagcatcc ggcaggctgc cctggcctcc tgcgtcagga      720

caacgcccac gaggggcgtt actgtgcgga gatgcaccac gcaagagaca ccctttgtaa      780

ctctcttctc ctccctagtg cgaggttaaa accttcagcc ccacgtgctg tttgcaaacc      840

tgcctgtacc tgaggcccta aaaagccaga gacctcactc ccggggagcc agcatgtcca      900

ctgcggtcct ggaaaaccca ggcttgggca ggaaactctc tgactttgga caggtgagcc      960

acggcagcct gagctgctca gttaggggaa tttgggcctc cagagaaaga gatctgaaga     1020

ctgctggtgc ttcctggttt cataagctca gtaagaagtc tgaattcgtt ggaagctgat     1080

gagaatatcc aggaagtcaa cagacaaatg tcctcaacaa ttgtttctaa gtaggagaac     1140

atctgtcctc ggtggctttc acaggaaaag cttctgacct cttctcttcc tcccacaggg     1200

cggtaccaga tctggcagcg gagagggcag aggaagtctt ctaacatgcg gtgacgtgga     1260

ggagaatccc ggccctaggg gtacctccac cgctgtgctg gagaaccctg ggctggggag     1320

gaaactgtca gacttcgggc aggtaagttt tatggaatgt gaatcataat tcaatttttc     1380

aacatgcgtt aggagggaca tttcaaactc ttttttaccc tagactttcc taccatcacc     1440

cagagtatcc agccaggagg ggaggggcta gagacaccag aagtttagca gggaggaggg     1500

cgtagggatt cggggaatga agggatggga ttcagactag ggccaggacc cagggatgga     1560

gagaaagaga tgagagtggt ttgggggctt ggtgacttag agaacagagc tgcaggctca     1620

gaggcacaca ggagtttctg ggctggcccg gcccccttcc aacccctcat tatggaatcc     1680

agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc ctactcatgt     1740

cccatataag ggaaattatg gaatcagcaa acagcaaaca cacagccctc cctgcctgct     1800

gaccttggac ctggggcaga ggtcagagac ctccttggct ctatgccacc tccaacatcc     1860

actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt ggtttaggta     1920

gtgtgagagg gctgaccatg ccttcttctt tttcctacag gaaacttcat acattgagga     1980

taactgtaac cagaatggcg ccatctctct gatcttcagc ctgaaggagg aagtgggcgc     2040

cctggcaaag gtgctgcgcc tgtttgagga gaacgacgtg aatctgaccc acatcgagtc     2100

ccggccttct agactgaaga aggacgagta cgagttcttt acccacctgg ataagcggtc     2160

cctgccagcc ctgacaaaca tcatcaagat cctgaggcac gacatcggag caaccgtgca     2220

cgagctgtct cgggacaaga agaaggatac cgtgccctgg ttccctcgga caatccagga     2280

gctggataga tttgccaacc agatcctgtc ttacggagca gagctggacg cagatcaccc     2340

tggcttcaag gacccagtgt atcgggcccg gagaaagcag tttgccgata tcgcctacaa     2400

ttataggcac ggacagccaa tccctcgcgt ggagtatatg gaggaggaga agaagacctg     2460

gggcacagtg ttcaagaccc tgaagagcct gtacaagaca cacgcctgct acgagtataa     2520

ccacatcttc cccctgctgg agaagtattg tggctttcac gaggacaata tccctcagct     2580

ggaggacgtg agccagttcc tgcagacctg cacaggcttt aggctgaggc cagtggcagg     2640

actgctgagc tcccgggact tcctgggagg actggccttc agagtgtttc actgcaccca     2700

gtacatcagg cacggctcca agccaatgta tacaccagag cccgacatct gtcacgagct     2760

gctgggccac gtgcccctgt ttagcgatag atccttcgcc cagttttccc aggagatcgg     2820

actggcatct ctgggagcac ctgacgagta catcgagaag ctggccacca tctattggtt     2880

cacagtggag tttggcctgt gcaagcaggg cgatagcatc aaggcctacg gagcaggact     2940

gctgtctagc ttcggcgagc tgcagtattg tctgtccgag aagccaaagc tgctgcccct     3000

ggagctggag aagaccgcca tccagaacta caccgtgaca gagttccagc ccctgtacta     3060

tgtggccgag tcttttaacg atgccaagga gaaggtgaga aatttcgccg ccacaatccc     3120

taggcccttc agcgtgcggt acgaccctta tacccagagg atcgaggtgc tggataatac     3180

acagcagctg aagatcctgg ctgactcaat caatagcgaa atcggaatcc tgtgctccgc     3240

cctgcagaaa atcaaaggta agcctatccc taaccctctc ctcggtctcg attctacgtg     3300

atcttgtgga aaggacgaaa caccggggaa ttcaaggcct ctcgagcctc tagaatcccc     3360

gagacgtttc gtctcgggat cactatagtg agtcgtatta cgtacacagt gcaggggaaa     3420

gaatagtaga gatccagaca tgataagata cattgatgag tttggacaaa ccacaactag     3480

aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac     3540

cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt     3600

tcagggggag gtgtgggagg ttttttaact gggatgggat gtggaatcct tctagatttc     3660

ttttgtaata tttataaagt gctctcagca aggtatcaaa atggcaaaat tgtgagtaac     3720

tatcctcctt tcattttggg aagaagatga ggcatgaaga gaattcagac agaaacttac     3780

tcagaccagg ggaggcagaa actaagcaga gaggaaaatg accaagagtt agccctgggc     3840

atggaatgtg aaagaaccct aaacgtgact tggaaataat gcccaaggta tattccattc     3900

tccgggattt gttggcattt tcttgaggtg aagaattgca gaatacattc tttaatgtga     3960

cctacatatt tacccatggg aggaagtctg ctcctggact cttgagattc agtcataaag     4020

cccaggccag ggaaataatg taagtctgca ggcccctgtc atcagtagga ttagggagaa     4080

gagttctcag tagaaaacag ggaggctgga gagaaaagaa tggttaatgt taacgttaat     4140

ataactagaa agactgcaga acttaggact gatttttatt tgaatcctta aaaaaaaaat     4200

ttcttatgaa aatagtacat ggctcttagg agacagaact tattgtacag aggaacagcg     4260

tgagagtcag agtgatccca gaacaggtcc tggctccatc ctgcacatag ttttggtgct     4320

gctggcaata cggtccccac aactgtggga aggggttagg ggcagggatc tcatcaggaa     4380

agcatagggg tttaaagttc tttatagagc acttagaaga ttgagaatcc acaaattata     4440

ttaataacaa acaaagtagt gtcgtgttat atagtaaatg tgaatttgca gacacattta     4500

gggaaaagtt ataattaaaa aaataggctg tatatatacc tgcaggtcta gatacgtaga     4560

taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac     4620

tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc     4680

gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agagagggag tggccaa        4737


<210>  138
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  006-SD.3 vector PAH coding sequence

<400>  138
atgtccaccg ctgtgctgga gaaccctggg ctggggagga aactgtcaga cttcgggcag       60

gagacttcat acattgagga taactgtaac cagaatggcg ccatctctct gatcttcagc      120

ctgaaggagg aagtgggcgc cctggcaaag gtgctgcgcc tgtttgagga gaacgacgtg      180

aatctgaccc acatcgagtc ccggccttct agactgaaga aggacgagta cgagttcttt      240

acccacctgg ataagcggtc cctgccagcc ctgacaaaca tcatcaagat cctgaggcac      300

gacatcggag caaccgtgca cgagctgtct cgggacaaga agaaggatac cgtgccctgg      360

ttccctcgga caatccagga gctggataga tttgccaacc agatcctgtc ttacggagca      420

gagctggacg cagatcaccc tggcttcaag gacccagtgt atcgggcccg gagaaagcag      480

tttgccgata tcgcctacaa ttataggcac ggacagccaa tccctcgcgt ggagtatatg      540

gaggaggaga agaagacctg gggcacagtg ttcaagaccc tgaagagcct gtacaagaca      600

cacgcctgct acgagtataa ccacatcttc cccctgctgg agaagtattg tggctttcac      660

gaggacaata tccctcagct ggaggacgtg agccagttcc tgcagacctg cacaggcttt      720

aggctgaggc cagtggcagg actgctgagc tcccgggact tcctgggagg actggccttc      780

agagtgtttc actgcaccca gtacatcagg cacggctcca agccaatgta tacaccagag      840

cccgacatct gtcacgagct gctgggccac gtgcccctgt ttagcgatag atccttcgcc      900

cagttttccc aggagatcgg actggcatct ctgggagcac ctgacgagta catcgagaag      960

ctggccacca tctattggtt cacagtggag tttggcctgt gcaagcaggg cgatagcatc     1020

aaggcctacg gagcaggact gctgtctagc ttcggcgagc tgcagtattg tctgtccgag     1080

aagccaaagc tgctgcccct ggagctggag aagaccgcca tccagaacta caccgtgaca     1140

gagttccagc ccctgtacta tgtggccgag tcttttaacg atgccaagga gaaggtgaga     1200

aatttcgccg ccacaatccc taggcccttc agtgtgcgtt acgaccctta tacccagagg     1260

atcgaggtgc tggataatac acagcagctg aagatcctgg ctgactcaat caatagcgaa     1320

atcggaatcc tgtgctccgc cctgcagaaa atcaaatga                            1359


<210>  139
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  032-SD.3 vector PAH coding sequence

<400>  139
tccaccgctg tgctggagaa ccctgggctg gggaggaaac tgtcagactt cgggcaggag       60

acttcataca ttgaggataa ctgtaaccag aatggcgcca tctctctgat cttcagcctg      120

aaggaggaag tgggcgccct ggcaaaggtg ctgcgcctgt ttgaggagaa cgacgtgaat      180

ctgacccaca tcgagtcccg gccttctaga ctgaagaagg acgagtacga gttctttacc      240

cacctggata agcggtccct gccagccctg acaaacatca tcaagatcct gaggcacgac      300

atcggagcaa ccgtgcacga gctgtctcgg gacaagaaga aggataccgt gccctggttc      360

cctcggacaa tccaggagct ggatagattt gccaaccaga tcctgtctta cggagcagag      420

ctggacgcag atcaccctgg cttcaaggac ccagtgtatc gggcccggag aaagcagttt      480

gccgatatcg cctacaatta taggcacgga cagccaatcc ctcgcgtgga gtatatggag      540

gaggagaaga agacctgggg cacagtgttc aagaccctga agagcctgta caagacacac      600

gcctgctacg agtataacca catcttcccc ctgctggaga agtattgtgg ctttcacgag      660

gacaatatcc ctcagctgga ggacgtgagc cagttcctgc agacctgcac aggctttagg      720

ctgaggccag tggcaggact gctgagctcc cgggacttcc tgggaggact ggccttcaga      780

gtgtttcact gcacccagta catcaggcac ggctccaagc caatgtatac accagagccc      840

gacatctgtc acgagctgct gggccacgtg cccctgttta gcgatagatc cttcgcccag      900

ttttcccagg agatcggact ggcatctctg ggagcacctg acgagtacat cgagaagctg      960

gccaccatct attggttcac agtggagttt ggcctgtgca agcagggcga tagcatcaag     1020

gcctacggag caggactgct gtctagcttc ggcgagctgc agtattgtct gtccgagaag     1080

ccaaagctgc tgcccctgga gctggagaag accgccatcc agaactacac cgtgacagag     1140

ttccagcccc tgtactatgt ggccgagtct tttaacgatg ccaaggagaa ggtgagaaat     1200

ttcgccgcca caatccctag gcccttcagt gtgcgttacg acccttatac ccagaggatc     1260

gaggtgctgg ataatacaca gcagctgaag atcctggctg actcaatcaa tagcgaaatc     1320

ggaatcctgt gctccgccct gcagaaaatc aaa                                  1353


<210>  140
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  37 bp additional 3' ITR sequence from wtAAV2

<400>  140
gtagataagt agcatggcgg gttaatcatt aactaca                                37


<210>  141
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' ITR with additional 37 bp sequence

<400>  141
gtagataagt agcatggcgg gttaatcatt aactacaagg aacccctagt gatggagttg       60

gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga      120

cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc      180


<210>  142
<211>  800
<212>  DNA
<213>  Mus musculus

<400>  142
agcattagct tccatttatg cagtgtaaat ggtgagaaca gccccgactg aatacccaga       60

gcatcatctc gtctgtgtca ttcatgcaca taacatatct cagcgaggtg gcccttctgt      120

cctctttgca gagacccagc caccatacta gtacctagag aactggctgg atttcagccc      180

cgatacctcc gggcttttgc tcatgttcgc ctcatagggt catctgggtg gttgcctaag      240

gaaaagtatg tcatggagac taacttgctt ggcattgaat aaaaggtgag ttgagagtgg      300

agcgtgttta aattgcaatc ctgcctctat ttctgtgctt gcagggaaca gtcatcctta      360

attgctatcc tccatcatca tcatgattat ttctggtttt tctctggttg cggagaatcc      420

atactccagg tattccaatg tctcagcatt gccaggcctg tctgagcgtc aggatgtagg      480

tagtctgggc tctctgcctt ctattcttgt ccaggatact ctgccaaaag aatcatgttg      540

tggctgccac ccctcccaca aagcctcccg cttgggtcag tccaggactg gagttgggta      600

tggactgttc atgtctatcc actgctacgt cagggcaaca cccactgaga gtgaccttgt      660

agactgcagt gggagacacc cttcaaaacc tctcatctcc tgtcctgaga gccaggttaa      720

aaccatcagc cccgcatcct gagtgcaaac ttttcctaac cctgctgcta agctagacac      780

ctcacttact gagagccagc                                                  800


<210>  143
<211>  1475
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  006-HBB1 vector PAH coding sequence

<400>  143
atgtccaccg ctgtgctgga gaaccctggg ctggggagga aactgtcaga cttcgggcag       60

gagacttcat acattgagga taactgtaac cagaatggcg ccatctctct gatcttcagc      120

ctgaaggagg aagtgggcgc cctggcaaag gtgctgcgcc tgtttgagga gaacgacgtg      180

aatctgaccc acatcgagtc ccggccttct agactgaaga aggacgagta cgagttcttt      240

acccacctgg ataagcggtc cctgccagcc ctgacaaaca tcatcaagat cctgaggcac      300

gacatcggag caaccgtgca cgagctgtct cgggacaaga agaaggatac cgtgccctgg      360

ttccctcgga caatccagga gctggataga tttgccaacc agatcctgtc ttacggagca      420

gagctggacg cagatcaccc tggcttcaag gacccagtgt atcgggcccg gagaaagcag      480

tttgccgata tcgcctacaa ttataggcac ggacagccaa tccctcgcgt ggagtatatg      540

gaggaggaga agaagacctg gggcacagtg ttcaagaccc tgaagagcct gtacaagaca      600

cacgcctgct acgagtataa ccacatcttc cccctgctgg agaagtattg tggctttcac      660

gaggacaata tccctcagct ggaggacgtg agccagttcc tgcagacctg cacaggcttt      720

aggctgaggc cagtggcagg actgctgagc tcccgggact tcctgggagg actggccttc      780

agagtgtttc actgcaccca gtacatcagg cacggctcca agccaatgta tacaccagag      840

cccgacatct gtcacgagct gctgggccac gtgcccctgt ttagcgatag atccttcgcc      900

cagttttccc aggttggtat ccaggttaca aggcagctca caagaagaag ttgggtgctt      960

ggagacagag gtctgctttc cagcagacac taactttcag tgtcccctgt ctatgtttcc     1020

ctttttagga gatcggactg gcatctctgg gagcacctga cgagtacatc gagaagctgg     1080

ccaccatcta ttggttcaca gtggagtttg gcctgtgcaa gcagggcgat agcatcaagg     1140

cctacggagc aggactgctg tctagcttcg gcgagctgca gtattgtctg tccgagaagc     1200

caaagctgct gcccctggag ctggagaaga ccgccatcca gaactacacc gtgacagagt     1260

tccagcccct gtactatgtg gccgagtctt ttaacgatgc caaggagaag gtgagaaatt     1320

tcgccgccac aatccctagg cccttcagcg tgcggtacga cccttatacc cagaggatcg     1380

aggtgctgga taatacacag cagctgaaga tcctggctga ctcaatcaat agcgaaatcg     1440

gaatcctgtg ctccgccctg cagaaaatca aatga                                1475


<210>  144
<211>  800
<212>  DNA
<213>  Mus musculus

<400>  144
gcagctgttg tcctggagaa cggagtcctg agcagaaaac tctcagactt tgggcaggta       60

agcctgttgg gcttccactg ctaggagaga attggttccc cacatgtgaa agcagtctgg      120

gaaatgctgg tatttccagt ctcctaaggc tactaagaaa tatgacttta tttagaggcg      180

agaaaaatgc ccaggaagtc aactgatgag actagtctta acaagttgag gatacagaaa      240

gttggggatc tgagctgcta ccaacatctg tgtgtctttg ggtggctcat tggtatcctc      300

tgcctattgg ctttatcttc tgtacactga aaggaaatgg ctggtcctta gtcacctggg      360

gtgggagtcc ctatctctcc agggatactt attcaatcct ttcttctggg tatcaaaatg      420

acaagcttgt aagaaactgt cctctttcgg ctttcaggag gtgatgtcgc atgaagagaa      480

tttggggggg gggacttact cagaaccaag gagggagaaa ttaaacagag agggaaatga      540

acaggagtta gcccggagcc tgaagcacct tggggattat gctgggggtg gagggaatcc      600

attgtcctcc ctagggaggg cttgcagaac atgttctttt ctgtgatatt tgtactttcc      660

ccagattgca aatcatggtt tgtacactga gattcagtct ctggaggtaa tatgcctttt      720

ctagcttttc cttggacagg actaaggggt tgagggttgc ctggagtcag agaaatttgt      780

gttaaagaag gttgatatga                                                  800


<210>  145
<211>  3343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  006-HBB1 vector correction genome

<400>  145
agcattagct tccatttatg cagtgtaaat ggtgagaaca gccccgactg aatacccaga       60

gcatcatctc gtctgtgtca ttcatgcaca taacatatct cagcgaggtg gcccttctgt      120

cctctttgca gagacccagc caccatacta gtacctagag aactggctgg atttcagccc      180

cgatacctcc gggcttttgc tcatgttcgc ctcatagggt catctgggtg gttgcctaag      240

gaaaagtatg tcatggagac taacttgctt ggcattgaat aaaaggtgag ttgagagtgg      300

agcgtgttta aattgcaatc ctgcctctat ttctgtgctt gcagggaaca gtcatcctta      360

attgctatcc tccatcatca tcatgattat ttctggtttt tctctggttg cggagaatcc      420

atactccagg tattccaatg tctcagcatt gccaggcctg tctgagcgtc aggatgtagg      480

tagtctgggc tctctgcctt ctattcttgt ccaggatact ctgccaaaag aatcatgttg      540

tggctgccac ccctcccaca aagcctcccg cttgggtcag tccaggactg gagttgggta      600

tggactgttc atgtctatcc actgctacgt cagggcaaca cccactgaga gtgaccttgt      660

agactgcagt gggagacacc cttcaaaacc tctcatctcc tgtcctgaga gccaggttaa      720

aaccatcagc cccgcatcct gagtgcaaac ttttcctaac cctgctgcta agctagacac      780

ctcacttact gagagccagc atgtccaccg ctgtgctgga gaaccctggg ctggggagga      840

aactgtcaga cttcgggcag gagacttcat acattgagga taactgtaac cagaatggcg      900

ccatctctct gatcttcagc ctgaaggagg aagtgggcgc cctggcaaag gtgctgcgcc      960

tgtttgagga gaacgacgtg aatctgaccc acatcgagtc ccggccttct agactgaaga     1020

aggacgagta cgagttcttt acccacctgg ataagcggtc cctgccagcc ctgacaaaca     1080

tcatcaagat cctgaggcac gacatcggag caaccgtgca cgagctgtct cgggacaaga     1140

agaaggatac cgtgccctgg ttccctcgga caatccagga gctggataga tttgccaacc     1200

agatcctgtc ttacggagca gagctggacg cagatcaccc tggcttcaag gacccagtgt     1260

atcgggcccg gagaaagcag tttgccgata tcgcctacaa ttataggcac ggacagccaa     1320

tccctcgcgt ggagtatatg gaggaggaga agaagacctg gggcacagtg ttcaagaccc     1380

tgaagagcct gtacaagaca cacgcctgct acgagtataa ccacatcttc cccctgctgg     1440

agaagtattg tggctttcac gaggacaata tccctcagct ggaggacgtg agccagttcc     1500

tgcagacctg cacaggcttt aggctgaggc cagtggcagg actgctgagc tcccgggact     1560

tcctgggagg actggccttc agagtgtttc actgcaccca gtacatcagg cacggctcca     1620

agccaatgta tacaccagag cccgacatct gtcacgagct gctgggccac gtgcccctgt     1680

ttagcgatag atccttcgcc cagttttccc aggttggtat ccaggttaca aggcagctca     1740

caagaagaag ttgggtgctt ggagacagag gtctgctttc cagcagacac taactttcag     1800

tgtcccctgt ctatgtttcc ctttttagga gatcggactg gcatctctgg gagcacctga     1860

cgagtacatc gagaagctgg ccaccatcta ttggttcaca gtggagtttg gcctgtgcaa     1920

gcagggcgat agcatcaagg cctacggagc aggactgctg tctagcttcg gcgagctgca     1980

gtattgtctg tccgagaagc caaagctgct gcccctggag ctggagaaga ccgccatcca     2040

gaactacacc gtgacagagt tccagcccct gtactatgtg gccgagtctt ttaacgatgc     2100

caaggagaag gtgagaaatt tcgccgccac aatccctagg cccttcagcg tgcggtacga     2160

cccttatacc cagaggatcg aggtgctgga taatacacag cagctgaaga tcctggctga     2220

ctcaatcaat agcgaaatcg gaatcctgtg ctccgccctg cagaaaatca aatgagaatt     2280

caaggcctct cgagcctcta gaactatagt gagtcgtatt acgtagatcc agacatgata     2340

agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt     2400

tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt     2460

aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt     2520

taagctttac gtacgatcgt cgagcagctg ttgtcctgga gaacggagtc ctgagcagaa     2580

aactctcaga ctttgggcag gtaagcctgt tgggcttcca ctgctaggag agaattggtt     2640

ccccacatgt gaaagcagtc tgggaaatgc tggtatttcc agtctcctaa ggctactaag     2700

aaatatgact ttatttagag gcgagaaaaa tgcccaggaa gtcaactgat gagactagtc     2760

ttaacaagtt gaggatacag aaagttgggg atctgagctg ctaccaacat ctgtgtgtct     2820

ttgggtggct cattggtatc ctctgcctat tggctttatc ttctgtacac tgaaaggaaa     2880

tggctggtcc ttagtcacct ggggtgggag tccctatctc tccagggata cttattcaat     2940

cctttcttct gggtatcaaa atgacaagct tgtaagaaac tgtcctcttt cggctttcag     3000

gaggtgatgt cgcatgaaga gaatttgggg ggggggactt actcagaacc aaggagggag     3060

aaattaaaca gagagggaaa tgaacaggag ttagcccgga gcctgaagca ccttggggat     3120

tatgctgggg gtggagggaa tccattgtcc tccctaggga gggcttgcag aacatgttct     3180

tttctgtgat atttgtactt tccccagatt gcaaatcatg gtttgtacac tgagattcag     3240

tctctggagg taatatgcct tttctagctt ttccttggac aggactaagg ggttgagggt     3300

tgcctggagt cagagaaatt tgtgttaaag aaggttgata tga                       3343


<210>  146
<211>  3751
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  006-HBB1 vector correction genome (+ ITRs)

<400>  146
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgcata tgcggccgca gcattagctt ccatttatgc agtgtaaatg      240

gtgagaacag ccccgactga atacccagag catcatctcg tctgtgtcat tcatgcacat      300

aacatatctc agcgaggtgg cccttctgtc ctctttgcag agacccagcc accatactag      360

tacctagaga actggctgga tttcagcccc gatacctccg ggcttttgct catgttcgcc      420

tcatagggtc atctgggtgg ttgcctaagg aaaagtatgt catggagact aacttgcttg      480

gcattgaata aaaggtgagt tgagagtgga gcgtgtttaa attgcaatcc tgcctctatt      540

tctgtgcttg cagggaacag tcatccttaa ttgctatcct ccatcatcat catgattatt      600

tctggttttt ctctggttgc ggagaatcca tactccaggt attccaatgt ctcagcattg      660

ccaggcctgt ctgagcgtca ggatgtaggt agtctgggct ctctgccttc tattcttgtc      720

caggatactc tgccaaaaga atcatgttgt ggctgccacc cctcccacaa agcctcccgc      780

ttgggtcagt ccaggactgg agttgggtat ggactgttca tgtctatcca ctgctacgtc      840

agggcaacac ccactgagag tgaccttgta gactgcagtg ggagacaccc ttcaaaacct      900

ctcatctcct gtcctgagag ccaggttaaa accatcagcc ccgcatcctg agtgcaaact      960

tttcctaacc ctgctgctaa gctagacacc tcacttactg agagccagca tgtccaccgc     1020

tgtgctggag aaccctgggc tggggaggaa actgtcagac ttcgggcagg agacttcata     1080

cattgaggat aactgtaacc agaatggcgc catctctctg atcttcagcc tgaaggagga     1140

agtgggcgcc ctggcaaagg tgctgcgcct gtttgaggag aacgacgtga atctgaccca     1200

catcgagtcc cggccttcta gactgaagaa ggacgagtac gagttcttta cccacctgga     1260

taagcggtcc ctgccagccc tgacaaacat catcaagatc ctgaggcacg acatcggagc     1320

aaccgtgcac gagctgtctc gggacaagaa gaaggatacc gtgccctggt tccctcggac     1380

aatccaggag ctggatagat ttgccaacca gatcctgtct tacggagcag agctggacgc     1440

agatcaccct ggcttcaagg acccagtgta tcgggcccgg agaaagcagt ttgccgatat     1500

cgcctacaat tataggcacg gacagccaat ccctcgcgtg gagtatatgg aggaggagaa     1560

gaagacctgg ggcacagtgt tcaagaccct gaagagcctg tacaagacac acgcctgcta     1620

cgagtataac cacatcttcc ccctgctgga gaagtattgt ggctttcacg aggacaatat     1680

ccctcagctg gaggacgtga gccagttcct gcagacctgc acaggcttta ggctgaggcc     1740

agtggcagga ctgctgagct cccgggactt cctgggagga ctggccttca gagtgtttca     1800

ctgcacccag tacatcaggc acggctccaa gccaatgtat acaccagagc ccgacatctg     1860

tcacgagctg ctgggccacg tgcccctgtt tagcgataga tccttcgccc agttttccca     1920

ggttggtatc caggttacaa ggcagctcac aagaagaagt tgggtgcttg gagacagagg     1980

tctgctttcc agcagacact aactttcagt gtcccctgtc tatgtttccc tttttaggag     2040

atcggactgg catctctggg agcacctgac gagtacatcg agaagctggc caccatctat     2100

tggttcacag tggagtttgg cctgtgcaag cagggcgata gcatcaaggc ctacggagca     2160

ggactgctgt ctagcttcgg cgagctgcag tattgtctgt ccgagaagcc aaagctgctg     2220

cccctggagc tggagaagac cgccatccag aactacaccg tgacagagtt ccagcccctg     2280

tactatgtgg ccgagtcttt taacgatgcc aaggagaagg tgagaaattt cgccgccaca     2340

atccctaggc ccttcagcgt gcggtacgac ccttataccc agaggatcga ggtgctggat     2400

aatacacagc agctgaagat cctggctgac tcaatcaata gcgaaatcgg aatcctgtgc     2460

tccgccctgc agaaaatcaa atgagaattc aaggcctctc gagcctctag aactatagtg     2520

agtcgtatta cgtagatcca gacatgataa gatacattga tgagtttgga caaaccacaa     2580

ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg     2640

taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc     2700

aggttcaggg ggaggtgtgg gaggtttttt aagctttacg tacgatcgtc gagcagctgt     2760

tgtcctggag aacggagtcc tgagcagaaa actctcagac tttgggcagg taagcctgtt     2820

gggcttccac tgctaggaga gaattggttc cccacatgtg aaagcagtct gggaaatgct     2880

ggtatttcca gtctcctaag gctactaaga aatatgactt tatttagagg cgagaaaaat     2940

gcccaggaag tcaactgatg agactagtct taacaagttg aggatacaga aagttgggga     3000

tctgagctgc taccaacatc tgtgtgtctt tgggtggctc attggtatcc tctgcctatt     3060

ggctttatct tctgtacact gaaaggaaat ggctggtcct tagtcacctg gggtgggagt     3120

ccctatctct ccagggatac ttattcaatc ctttcttctg ggtatcaaaa tgacaagctt     3180

gtaagaaact gtcctctttc ggctttcagg aggtgatgtc gcatgaagag aatttggggg     3240

gggggactta ctcagaacca aggagggaga aattaaacag agagggaaat gaacaggagt     3300

tagcccggag cctgaagcac cttggggatt atgctggggg tggagggaat ccattgtcct     3360

ccctagggag ggcttgcaga acatgttctt ttctgtgata tttgtacttt ccccagattg     3420

caaatcatgg tttgtacact gagattcagt ctctggaggt aatatgcctt ttctagcttt     3480

tccttggaca ggactaaggg gttgagggtt gcctggagtc agagaaattt gtgttaaaga     3540

aggttgatat gacctgcagg tctagatacg tagataagta gcatggcggg ttaatcatta     3600

actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     3660

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     3720

gcgagcgagc gcgcagagag ggagtggcca a                                    3751


<210>  147
<211>  1607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  006 vector editing element

<400>  147
atgtccaccg ctgtgctgga gaaccctggg ctggggagga aactgtcaga cttcgggcag       60

gagacttcat acattgagga taactgtaac cagaatggcg ccatctctct gatcttcagc      120

ctgaaggagg aagtgggcgc cctggcaaag gtgctgcgcc tgtttgagga gaacgacgtg      180

aatctgaccc acatcgagtc ccggccttct agactgaaga aggacgagta cgagttcttt      240

acccacctgg ataagcggtc cctgccagcc ctgacaaaca tcatcaagat cctgaggcac      300

gacatcggag caaccgtgca cgagctgtct cgggacaaga agaaggatac cgtgccctgg      360

ttccctcgga caatccagga gctggataga tttgccaacc agatcctgtc ttacggagca      420

gagctggacg cagatcaccc tggcttcaag gacccagtgt atcgggcccg gagaaagcag      480

tttgccgata tcgcctacaa ttataggcac ggacagccaa tccctcgcgt ggagtatatg      540

gaggaggaga agaagacctg gggcacagtg ttcaagaccc tgaagagcct gtacaagaca      600

cacgcctgct acgagtataa ccacatcttc cccctgctgg agaagtattg tggctttcac      660

gaggacaata tccctcagct ggaggacgtg agccagttcc tgcagacctg cacaggcttt      720

aggctgaggc cagtggcagg actgctgagc tcccgggact tcctgggagg actggccttc      780

agagtgtttc actgcaccca gtacatcagg cacggctcca agccaatgta tacaccagag      840

cccgacatct gtcacgagct gctgggccac gtgcccctgt ttagcgatag atccttcgcc      900

cagttttccc aggagatcgg actggcatct ctgggagcac ctgacgagta catcgagaag      960

ctggccacca tctattggtt cacagtggag tttggcctgt gcaagcaggg cgatagcatc     1020

aaggcctacg gagcaggact gctgtctagc ttcggcgagc tgcagtattg tctgtccgag     1080

aagccaaagc tgctgcccct ggagctggag aagaccgcca tccagaacta caccgtgaca     1140

gagttccagc ccctgtacta tgtggccgag tcttttaacg atgccaagga gaaggtgaga     1200

aatttcgccg ccacaatccc taggcccttc agcgtgcggt acgaccctta tacccagagg     1260

atcgaggtgc tggataatac acagcagctg aagatcctgg ctgactcaat caatagcgaa     1320

atcggaatcc tgtgctccgc cctgcagaaa atcaaatgag aattcaaggc ctctcgagcc     1380

tctagaacta tagtgagtcg tattacgtag atccagacat gataagatac attgatgagt     1440

ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg     1500

ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca     1560

ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaa                   1607


<210>  148
<211>  1837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  032 vector editing element

<400>  148
ctgacctctt ctcttcctcc cacagggcgg taccagatct ggcagcggag agggcagagg       60

aagtcttcta acatgcggtg acgtggagga gaatcccggc cctaggggta cctccaccgc      120

tgtgctggag aaccctgggc tggggaggaa actgtcagac ttcgggcagg agacttcata      180

cattgaggat aactgtaacc agaatggcgc catctctctg atcttcagcc tgaaggagga      240

agtgggcgcc ctggcaaagg tgctgcgcct gtttgaggag aacgacgtga atctgaccca      300

catcgagtcc cggccttcta gactgaagaa ggacgagtac gagttcttta cccacctgga      360

taagcggtcc ctgccagccc tgacaaacat catcaagatc ctgaggcacg acatcggagc      420

aaccgtgcac gagctgtctc gggacaagaa gaaggatacc gtgccctggt tccctcggac      480

aatccaggag ctggatagat ttgccaacca gatcctgtct tacggagcag agctggacgc      540

agatcaccct ggcttcaagg acccagtgta tcgggcccgg agaaagcagt ttgccgatat      600

cgcctacaat tataggcacg gacagccaat ccctcgcgtg gagtatatgg aggaggagaa      660

gaagacctgg ggcacagtgt tcaagaccct gaagagcctg tacaagacac acgcctgcta      720

cgagtataac cacatcttcc ccctgctgga gaagtattgt ggctttcacg aggacaatat      780

ccctcagctg gaggacgtga gccagttcct gcagacctgc acaggcttta ggctgaggcc      840

agtggcagga ctgctgagct cccgggactt cctgggagga ctggccttca gagtgtttca      900

ctgcacccag tacatcaggc acggctccaa gccaatgtat acaccagagc ccgacatctg      960

tcacgagctg ctgggccacg tgcccctgtt tagcgataga tccttcgccc agttttccca     1020

ggagatcgga ctggcatctc tgggagcacc tgacgagtac atcgagaagc tggccaccat     1080

ctattggttc acagtggagt ttggcctgtg caagcagggc gatagcatca aggcctacgg     1140

agcaggactg ctgtctagct tcggcgagct gcagtattgt ctgtccgaga agccaaagct     1200

gctgcccctg gagctggaga agaccgccat ccagaactac accgtgacag agttccagcc     1260

cctgtactat gtggccgagt cttttaacga tgccaaggag aaggtgagaa atttcgccgc     1320

cacaatccct aggcccttca gcgtgcggta cgacccttat acccagagga tcgaggtgct     1380

ggataataca cagcagctga agatcctggc tgactcaatc aatagcgaaa tcggaatcct     1440

gtgctccgcc ctgcagaaaa tcaaaggtaa gcctatccct aaccctctcc tcggtctcga     1500

ttctacgtga tcttgtggaa aggacgaaac accggggaat tcaaggcctc tcgagcctct     1560

agaatccccg agacgtttcg tctcgggatc actatagtga gtcgtattac gtacacagtg     1620

caggggaaag aatagtagag atccagacat gataagatac attgatgagt ttggacaaac     1680

cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt     1740

atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat     1800

gtttcaggtt cagggggagg tgtgggaggt tttttaa                              1837


<210>  149
<211>  2225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  006-HCR vector editing element

<400>  149
atgtccaccg ctgtgctgga gaaccctggg ctggggagga aactgtcaga cttcgggcag       60

gtaagtttta tggaatgtga atcataattc aatttttcaa catgcgttag gagggacatt      120

tcaaactctt ttttacccta gactttccta ccatcaccca gagtatccag ccaggagggg      180

aggggctaga gacaccagaa gtttagcagg gaggagggcg tagggattcg gggaatgaag      240

ggatgggatt cagactaggg ccaggaccca gggatggaga gaaagagatg agagtggttt      300

gggggcttgg tgacttagag aacagagctg caggctcaga ggcacacagg agtttctggg      360

ctggcccggc ccccttccaa cccctcatta tggaatccag cagctgtttg tgtgctgcct      420

ctgaagtcca cactgaacaa acttcagcct actcatgtcc catataaggg aaattatgga      480

atcagcaaac agcaaacaca cagccctccc tgcctgctga ccttggacct ggggcagagg      540

tcagagacct ccttggctct atgccacctc caacatccac tcgacccctt ggaatttcgg      600

tggagaggag cagaggttgt cctggcgtgg tttaggtagt gtgagagggc tgaccatgcc      660

ttcttctttt tcctacagga aacttcatac attgaggata actgtaacca gaatggcgcc      720

atctctctga tcttcagcct gaaggaggaa gtgggcgccc tggcaaaggt gctgcgcctg      780

tttgaggaga acgacgtgaa tctgacccac atcgagtccc ggccttctag actgaagaag      840

gacgagtacg agttctttac ccacctggat aagcggtccc tgccagccct gacaaacatc      900

atcaagatcc tgaggcacga catcggagca accgtgcacg agctgtctcg ggacaagaag      960

aaggataccg tgccctggtt ccctcggaca atccaggagc tggatagatt tgccaaccag     1020

atcctgtctt acggagcaga gctggacgca gatcaccctg gcttcaagga cccagtgtat     1080

cgggcccgga gaaagcagtt tgccgatatc gcctacaatt ataggcacga acagccaatc     1140

cctcgcgtgg agtatatgga ggaggagaag aagacctggg gcacagtgtt caagaccctg     1200

aagagcctgt acaagacaca cgcctgctac gagtataacc acatcttccc cctgctggag     1260

aagtattgtg gctttcacga ggacaatatc cctcagctgg aggacgtgag ccagttcctg     1320

cagacctgca caggctttag gctgaggcca gtggcaggac tgctgagctc ccgggacttc     1380

ctgggaggac tggccttcag agtgtttcac tgcacccagt acatcaggca cggctccaag     1440

ccaatgtata caccagagcc cgacatctgt cacgagctgc tgggccacgt gcccctgttt     1500

agcgatagat ccttcgccca gttttcccag gagatcggac tggcatctct gggagcacct     1560

gacgagtaca tcgagaagct ggccaccatc tattggttca cagtggagtt tggcctgtgc     1620

aagcagggcg atagcatcaa ggcctacgga gcaggactgc tgtctagctt cggcgagctg     1680

cagtattgtc tgtccgagaa gccaaagctg ctgcccctgg agctggagaa gaccgccatc     1740

cagaactaca ccgtgacaga gttccagccc ctgtactatg tggccgagtc ttttaacgat     1800

gccaaggaga aggtgagaaa tttcgccgcc acaatcccta ggcccttcag cgtgcggtac     1860

gacccttata cccagaggat cgaggtgctg gataatacac agcagctgaa gatcctggct     1920

gactcaatca atagcgaaat cggaatcctg tgctccgccc tgcagaaaat caaatgagaa     1980

ttcaaggcct ctcgagcctc tagaactata gtgagtcgta ttacgtagat ccagacatga     2040

taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta     2100

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag     2160

ttaacaacaa caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt     2220

tttaa                                                                 2225


<210>  150
<211>  2455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  032-HCR vector editing element

<400>  150
ctgacctctt ctcttcctcc cacagggcgg taccagatct ggcagcggag agggcagagg       60

aagtcttcta acatgcggtg acgtggagga gaatcccggc cctaggggta cctccaccgc      120

tgtgctggag aaccctgggc tggggaggaa actgtcagac ttcgggcagg taagttttat      180

ggaatgtgaa tcataattca atttttcaac atgcgttagg agggacattt caaactcttt      240

tttaccctag actttcctac catcacccag agtatccagc caggagggga ggggctagag      300

acaccagaag tttagcaggg aggagggcgt agggattcgg ggaatgaagg gatgggattc      360

agactagggc caggacccag ggatggagag aaagagatga gagtggtttg ggggcttggt      420

gacttagaga acagagctgc aggctcagag gcacacagga gtttctgggc tggcccggcc      480

cccttccaac ccctcattat ggaatccagc agctgtttgt gtgctgcctc tgaagtccac      540

actgaacaaa cttcagccta ctcatgtccc atataaggga aattatggaa tcagcaaaca      600

gcaaacacac agccctccct gcctgctgac cttggacctg gggcagaggt cagagacctc      660

cttggctcta tgccacctcc aacatccact cgaccccttg gaatttcggt ggagaggagc      720

agaggttgtc ctggcgtggt ttaggtagtg tgagagggct gaccatgcct tcttcttttt      780

cctacaggaa acttcataca ttgaggataa ctgtaaccag aatggcgcca tctctctgat      840

cttcagcctg aaggaggaag tgggcgccct ggcaaaggtg ctgcgcctgt ttgaggagaa      900

cgacgtgaat ctgacccaca tcgagtcccg gccttctaga ctgaagaagg acgagtacga      960

gttctttacc cacctggata agcggtccct gccagccctg acaaacatca tcaagatcct     1020

gaggcacgac atcggagcaa ccgtgcacga gctgtctcgg gacaagaaga aggataccgt     1080

gccctggttc cctcggacaa tccaggagct ggatagattt gccaaccaga tcctgtctta     1140

cggagcagag ctggacgcag atcaccctgg cttcaaggac ccagtgtatc gggcccggag     1200

aaagcagttt gccgatatcg cctacaatta taggcacgga cagccaatcc ctcgcgtgga     1260

gtatatggag gaggagaaga agacctgggg cacagtgttc aagaccctga agagcctgta     1320

caagacacac gcctgctacg agtataacca catcttcccc ctgctggaga agtattgtgg     1380

ctttcacgag gacaatatcc ctcagctgga ggacgtgagc cagttcctgc agacctgcac     1440

aggctttagg ctgaggccag tggcaggact gctgagctcc cgggacttcc tgggaggact     1500

ggccttcaga gtgtttcact gcacccagta catcaggcac ggctccaagc caatgtatac     1560

accagagccc gacatctgtc acgagctgct gggccacgtg cccctgttta gcgatagatc     1620

cttcgcccag ttttcccagg agatcggact ggcatctctg ggagcacctg acgagtacat     1680

cgagaagctg gccaccatct attggttcac agtggagttt ggcctgtgca agcagggcga     1740

tagcatcaag gcctacggag caggactgct gtctagcttc ggcgagctgc agtattgtct     1800

gtccgagaag ccaaagctgc tgcccctgga gctggagaag accgccatcc agaactacac     1860

cgtgacagag ttccagcccc tgtactatgt ggccgagtct tttaacgatg ccaaggagaa     1920

ggtgagaaat ttcgccgcca caatccctag gcccttcagc gtgcggtacg acccttatac     1980

ccagaggatc gaggtgctgg ataatacaca gcagctgaag atcctggctg actcaatcaa     2040

tagcgaaatc ggaatcctgt gctccgccct gcagaaaatc aaaggtaagc ctatccctaa     2100

ccctctcctc ggtctcgatt ctacgtgatc ttgtggaaag gacgaaacac cggggaattc     2160

aaggcctctc gagcctctag aatccccgag acgtttcgtc tcgggatcac tatagtgagt     2220

cgtattacgt acacagtgca ggggaaagaa tagtagagat ccagacatga taagatacat     2280

tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat     2340

ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa     2400

caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaa          2455


<210>  151
<211>  1723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  006-HBB1 vector editing element

<400>  151
atgtccaccg ctgtgctgga gaaccctggg ctggggagga aactgtcaga cttcgggcag       60

gagacttcat acattgagga taactgtaac cagaatggcg ccatctctct gatcttcagc      120

ctgaaggagg aagtgggcgc cctggcaaag gtgctgcgcc tgtttgagga gaacgacgtg      180

aatctgaccc acatcgagtc ccggccttct agactgaaga aggacgagta cgagttcttt      240

acccacctgg ataagcggtc cctgccagcc ctgacaaaca tcatcaagat cctgaggcac      300

gacatcggag caaccgtgca cgagctgtct cgggacaaga agaaggatac cgtgccctgg      360

ttccctcgga caatccagga gctggataga tttgccaacc agatcctgtc ttacggagca      420

gagctggacg cagatcaccc tggcttcaag gacccagtgt atcgggcccg gagaaagcag      480

tttgccgata tcgcctacaa ttataggcac ggacagccaa tccctcgcgt ggagtatatg      540

gaggaggaga agaagacctg gggcacagtg ttcaagaccc tgaagagcct gtacaagaca      600

cacgcctgct acgagtataa ccacatcttc cccctgctgg agaagtattg tggctttcac      660

gaggacaata tccctcagct ggaggacgtg agccagttcc tgcagacctg cacaggcttt      720

aggctgaggc cagtggcagg actgctgagc tcccgggact tcctgggagg actggccttc      780

agagtgtttc actgcaccca gtacatcagg cacggctcca agccaatgta tacaccagag      840

cccgacatct gtcacgagct gctgggccac gtgcccctgt ttagcgatag atccttcgcc      900

cagttttccc aggttggtat ccaggttaca aggcagctca caagaagaag ttgggtgctt      960

ggagacagag gtctgctttc cagcagacac taactttcag tgtcccctgt ctatgtttcc     1020

ctttttagga gatcggactg gcatctctgg gagcacctga cgagtacatc gagaagctgg     1080

ccaccatcta ttggttcaca gtggagtttg gcctgtgcaa gcagggcgat agcatcaagg     1140

cctacggagc aggactgctg tctagcttcg gcgagctgca gtattgtctg tccgagaagc     1200

caaagctgct gcccctggag ctggagaaga ccgccatcca gaactacacc gtgacagagt     1260

tccagcccct gtactatgtg gccgagtctt ttaacgatgc caaggagaag gtgagaaatt     1320

tcgccgccac aatccctagg cccttcagcg tgcggtacga cccttatacc cagaggatcg     1380

aggtgctgga taatacacag cagctgaaga tcctggctga ctcaatcaat agcgaaatcg     1440

gaatcctgtg ctccgccctg cagaaaatca aatgagaatt caaggcctct cgagcctcta     1500

gaactatagt gagtcgtatt acgtagatcc agacatgata agatacattg atgagtttgg     1560

acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat     1620

tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca     1680

ttttatgttt caggttcagg gggaggtgtg ggaggttttt taa                       1723


<210>  152
<211>  1607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  006-SD.3 vector editing element

<400>  152
atgtccaccg ctgtgctgga gaaccctggg ctggggagga aactgtcaga cttcgggcag       60

gagacttcat acattgagga taactgtaac cagaatggcg ccatctctct gatcttcagc      120

ctgaaggagg aagtgggcgc cctggcaaag gtgctgcgcc tgtttgagga gaacgacgtg      180

aatctgaccc acatcgagtc ccggccttct agactgaaga aggacgagta cgagttcttt      240

acccacctgg ataagcggtc cctgccagcc ctgacaaaca tcatcaagat cctgaggcac      300

gacatcggag caaccgtgca cgagctgtct cgggacaaga agaaggatac cgtgccctgg      360

ttccctcgga caatccagga gctggataga tttgccaacc agatcctgtc ttacggagca      420

gagctggacg cagatcaccc tggcttcaag gacccagtgt atcgggcccg gagaaagcag      480

tttgccgata tcgcctacaa ttataggcac ggacagccaa tccctcgcgt ggagtatatg      540

gaggaggaga agaagacctg gggcacagtg ttcaagaccc tgaagagcct gtacaagaca      600

cacgcctgct acgagtataa ccacatcttc cccctgctgg agaagtattg tggctttcac      660

gaggacaata tccctcagct ggaggacgtg agccagttcc tgcagacctg cacaggcttt      720

aggctgaggc cagtggcagg actgctgagc tcccgggact tcctgggagg actggccttc      780

agagtgtttc actgcaccca gtacatcagg cacggctcca agccaatgta tacaccagag      840

cccgacatct gtcacgagct gctgggccac gtgcccctgt ttagcgatag atccttcgcc      900

cagttttccc aggagatcgg actggcatct ctgggagcac ctgacgagta catcgagaag      960

ctggccacca tctattggtt cacagtggag tttggcctgt gcaagcaggg cgatagcatc     1020

aaggcctacg gagcaggact gctgtctagc ttcggcgagc tgcagtattg tctgtccgag     1080

aagccaaagc tgctgcccct ggagctggag aagaccgcca tccagaacta caccgtgaca     1140

gagttccagc ccctgtacta tgtggccgag tcttttaacg atgccaagga gaaggtgaga     1200

aatttcgccg ccacaatccc taggcccttc agtgtgcgtt acgaccctta tacccagagg     1260

atcgaggtgc tggataatac acagcagctg aagatcctgg ctgactcaat caatagcgaa     1320

atcggaatcc tgtgctccgc cctgcagaaa atcaaatgag aattcaaggc ctctcgagcc     1380

tctagaacta tagtgagtcg tattacgtag atccagacat gataagatac attgatgagt     1440

ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg     1500

ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca     1560

ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaa                   1607


<210>  153
<211>  1837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  032-SD.3 vector editing element

<400>  153
ctgacctctt ctcttcctcc cacagggcgg taccagatct ggcagcggag agggcagagg       60

aagtcttcta acatgcggtg acgtggagga gaatcccggc cctaggggta cctccaccgc      120

tgtgctggag aaccctgggc tggggaggaa actgtcagac ttcgggcagg agacttcata      180

cattgaggat aactgtaacc agaatggcgc catctctctg atcttcagcc tgaaggagga      240

agtgggcgcc ctggcaaagg tgctgcgcct gtttgaggag aacgacgtga atctgaccca      300

catcgagtcc cggccttcta gactgaagaa ggacgagtac gagttcttta cccacctgga      360

taagcggtcc ctgccagccc tgacaaacat catcaagatc ctgaggcacg acatcggagc      420

aaccgtgcac gagctgtctc gggacaagaa gaaggatacc gtgccctggt tccctcggac      480

aatccaggag ctggatagat ttgccaacca gatcctgtct tacggagcag agctggacgc      540

agatcaccct ggcttcaagg acccagtgta tcgggcccgg agaaagcagt ttgccgatat      600

cgcctacaat tataggcacg gacagccaat ccctcgcgtg gagtatatgg aggaggagaa      660

gaagacctgg ggcacagtgt tcaagaccct gaagagcctg tacaagacac acgcctgcta      720

cgagtataac cacatcttcc ccctgctgga gaagtattgt ggctttcacg aggacaatat      780

ccctcagctg gaggacgtga gccagttcct gcagacctgc acaggcttta ggctgaggcc      840

agtggcagga ctgctgagct cccgggactt cctgggagga ctggccttca gagtgtttca      900

ctgcacccag tacatcaggc acggctccaa gccaatgtat acaccagagc ccgacatctg      960

tcacgagctg ctgggccacg tgcccctgtt tagcgataga tccttcgccc agttttccca     1020

ggagatcgga ctggcatctc tgggagcacc tgacgagtac atcgagaagc tggccaccat     1080

ctattggttc acagtggagt ttggcctgtg caagcagggc gatagcatca aggcctacgg     1140

agcaggactg ctgtctagct tcggcgagct gcagtattgt ctgtccgaga agccaaagct     1200

gctgcccctg gagctggaga agaccgccat ccagaactac accgtgacag agttccagcc     1260

cctgtactat gtggccgagt cttttaacga tgccaaggag aaggtgagaa atttcgccgc     1320

cacaatccct aggcccttca gtgtgcgtta cgacccttat acccagagga tcgaggtgct     1380

ggataataca cagcagctga agatcctggc tgactcaatc aatagcgaaa tcggaatcct     1440

gtgctccgcc ctgcagaaaa tcaaaggtaa gcctatccct aaccctctcc tcggtctcga     1500

ttctacgtga tcttgtggaa aggacgaaac accggggaat tcaaggcctc tcgagcctct     1560

agaatccccg agacgtttcg tctcgggatc actatagtga gtcgtattac gtacacagtg     1620

caggggaaag aatagtagag atccagacat gataagatac attgatgagt ttggacaaac     1680

cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt     1740

atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat     1800

gtttcaggtt cagggggagg tgtgggaggt tttttaa                              1837


