                         SEQUENCE LISTING

<110>  Bergen Teknologioverforing AS
 
<120>  antibodyagainst alpha-11 integrin and its use

<130>  4200-031 PCT-1

<150>  EP18155716.6
<151>  2018-02-08

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR1 heavy chain clone DSM Acc 3318

<400>  1

Asn Tyr Ala Val His 
1               5   


<210>  2
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 heavy chain clone DSM Acc 3318

<400>  2

Val Ile Trp Ser Tyr Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  3
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 heavy chain clone DSM Acc 3318

<400>  3

Ser Gln Ile Tyr Gly Gly Phe Tyr Asp Phe Phe Asp Phe 
1               5                   10              


<210>  4
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  CDR1 light chain clone DSM Acc 3318

<400>  4

Arg Ala Ser Gln Asp Ile Ser Asn Phe Leu Asn 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 light chain clone DSM Acc 3318

<400>  5

Tyr Ser Ser Arg Leu His Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 light chain clone DSM Acc 3318

<400>  6

Gln Gln Gly Asn Thr Leu Pro Leu Thr 
1               5                   


<210>  7
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  CDR1 heavy chain clone DSM ACC 3319

<400>  7

Asn Ser Ala Val His 
1               5   


<210>  8
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 heavy chain clone DSM ACC 3319

<400>  8

Val Val Trp Ser Tyr Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  9
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 heavy chain clone DSM ACC 3319

<400>  9

Ser Gln Ile Tyr Ala Asp Tyr Tyr Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  10
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  CDR1 light chain clone DSM ACC 3319

<400>  10

Arg Ala Ser Gln Asp Ile Ser Asn Phe Leu Asn 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  CDR2 light chain clone DSM ACC 3319

<400>  11

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  CDR3 light chain clone DSM ACC 3319

<400>  12

Gln Gln Gly Asn Thr Leu Pro Leu Thr 
1               5                   


<210>  13
<211>  121
<212>  PRT
<213>  artificial

<220>
<223>  CDR and FR heavy chain clone DSM ACC 3318

<400>  13

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Tyr Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Lys Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Thr Met Ser Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Gln Ile Tyr Gly Gly Phe Tyr Asp Phe Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  14
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  CDR with FR light chain clone DSM ACC 3318

<400>  14

Cys Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Ile Cys Arg Ala Ser Gln Asp Ile Ser Asn 
            20                  25                  30          


Phe Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Ser Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
65                  70                  75                  80  


Gln Glu Asp Leu Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Thr 
            100                 105             


<210>  15
<211>  121
<212>  PRT
<213>  artificial

<220>
<223>  CDR with FR heavy chain clone DSM ACC 3319

<400>  15

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Ser 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Val Trp Ser Tyr Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Gln Ile Tyr Ala Asp Tyr Tyr Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  CDR with FR light chain clone DSM ACC 3319

<400>  16

Asp Ile Gln Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Phe 
            20                  25                  30          


Leu Asn Trp Ser Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Gly Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg 
            100                 105         


<210>  17
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  integrin alpha miotif


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Gly Phe Phe Xaa Arg 
1               5   


<210>  18
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  integrin alpha 11 motif

<400>  18

Gly Phe Phe Arg Ser 
1               5   


<210>  19
<211>  420
<212>  DNA
<213>  artificial

<220>
<223>  nucleic acid sequnece of heavy chain clone DSM ACC 3318

<400>  19
atggctatcc tggcactgct cctctgcctg gtgactttcc caagctgtgc cctgtcccag       60

gtgcagctga aggagtcagg acctggcctg gtggcgccct cacagagcct gtccatcacc      120

tgcacagtct ctggtttctc attaaccaac tatgctgtac actgggttcg ccagtctcca      180

ggaaagggtc tggagtggct gggagtgata tggagttatg gcagcacaga ctataatgca      240

gctttcatat ctaaactgag catcagcaag gacaactcca agagccaagt tttctttaca      300

atgagcagtc tccaagctga tgacacagcc atatactact gtgccagaag tcagatctat      360

ggtggtttct acgacttctt tgacttctgg ggccaaggca ccactctcac agtctcctca      420


<210>  20
<211>  378
<212>  DNA
<213>  artificial

<220>
<223>  nucleic acid seqeunces light chain of clone DSM ACC 3318

<400>  20
atgtcctctg ctcagttcct tggtctcctg ttgctctgtt ttcaaggtac cagatgtgat       60

atccagatga cacagactcc atcctccctg tctgcctctc tgggagacag agtcaccatc      120

atttgcaggg caagtcagga cattagcaat tttttaaact ggtttcagca gaaaccagat      180

ggaactatta aactcctgat ctattactca tcaagattac actcaggagt cccatcaagg      240

ttcagtggca gtgggtctgg aacagattat tctctcacca ttagcaacct ggaacaagag      300

gatcttgcca cttacttttg ccaacagggt aatacgcttc cgctcacgtt cggcgctggg      360

accaagctgg aactgaca                                                    378


<210>  21
<211>  420
<212>  DNA
<213>  artificial

<220>
<223>  nucleic acid sequence of heavy chain clone DSM ACC 3319

<400>  21
atggctatcc tggcactgct cctctgcctg gtgactttcc caagctgtgc cctgtcccag       60

gtgcagctga aggagtcagg acctggcctg gtggcgccct cacagagcct gtccatcacc      120

tgcacagtct ctggtttctc attaaccaac tctgctgtac actgggttcg ccagtctcca      180

ggaaagggtc tggagtggct gggagtagta tggagttatg gcagcacaga ctataatgca      240

gctttcatat ctagactgag catcaccaag gacaactcca agagccaagt tttctttaaa      300

atgaatagtc tgcaagctga tgacacagcc atatattact gtgccagaag tcagatctat      360

gctgattact acgactactt tgactactgg ggccagggca ccactctcac agtctcctca      420


<210>  22
<211>  378
<212>  DNA
<213>  artificial

<220>
<223>  nucleic acid sequence of light chain clone DSM ACC 3319

<400>  22
atgtcctctg ctcagttcct tggtctcctg ttgctctgtt ttcaaggtac cagatgtgat       60

atccagatga cacagagtac atcctccctg tctgcctctc tgggagacag agtcaccatc      120

agttgcaggg caagtcaaga cattagcaat tttttaaact ggtctcagca gaaaccagat      180

ggaactgtta aactcctgat ctactacact tcaagattac actcaggggt cccatcaagg      240

ttcagtggca gtgggtctgg aacagattat tctctcacca ttagtaacct ggagcaggaa      300

gatattggca cttacttttg tcaacagggt aatacgcttc cgctcacgtt cggtgctggg      360

accaagctgg agctgaga                                                    378


