                         SEQUENCE LISTING

<110>  ULTRAHUMAN FIVE LIMITED
 
<120>  C-KIT BINDING AGENTS

<130>  UHFL-001/01WO 332948-2003

<150>  GB 1806468.3
<151>  2018-04-20

<150>  GB 1802201.2
<151>  2018-02-09

<160>  210   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR1


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Asp or a conservative substitution of Asp

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Tyr or a conservative substitution of Tyr

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Met or a conservative substitution of Met

<400>  1

Gly Tyr Thr Phe Thr Xaa Xaa Tyr Xaa Asn 
1               5                   10  


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Met or a conservative substitution of Met

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Gly or a conservative substitution of Gly

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Gly or a conservative substitution of Gly

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Ser or a conservative substitution of Ser

<400>  2

Xaa Xaa Arg Ile Tyr Pro Xaa Xaa Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3


<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  Xaa is Tyr or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Asp or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Tyr or any other amino acid

<400>  3

Gly Val Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  37M murine/humanized antibody HCDR1

<400>  4

Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile Asn 
1               5                   10  


<210>  5
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  37M murine/humanized antibody HCDR2

<400>  5

Ile Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys 
1               5                   10                  15      


Phe Lys Gly 
            


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  37M murine/humanized antibody HCDR3

<400>  6

Gly Val Tyr Tyr Phe Asp Tyr 
1               5           


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ile or a conservative substitution of Ile

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Arg or a conservative substitution of Arg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Thr or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asn or any other amino acid

<400>  7

Arg Ala Ser Gln Gly Xaa Xaa Xaa Xaa Leu Ala 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Ala or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ser or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Leu or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Gln or any other amino acid

<400>  8

Xaa Ala Ser Xaa Xaa Xaa Ser 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Asn or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser or any other amino acid

<400>  9

Gln Gln Tyr Xaa Xaa Tyr Pro Arg Thr 
1               5                   


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  37M murine/humanized antibody LCDR1

<400>  10

Lys Ala Ser Gln Asn Val Arg Thr Asn Val Ala 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  37M murine/humanized antibody LCDR2

<400>  11

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  37M murine/humanized antibody LCDR3

<400>  12

Gln Gln Tyr Asn Ser Tyr Pro Arg Thr 
1               5                   


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR1

<400>  13

Gly Tyr Thr Phe Thr Asp Tyr Tyr Met Asn 
1               5                   10  


<210>  14
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  14

Met Gly Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  15

Gly Val Tyr Tyr Tyr Asp Tyr 
1               5           


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  16

Arg Ala Ser Gln Gly Ile Arg Thr Asn Leu Ala 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  17

Ser Ala Ser Ser Leu Gln Ser 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  18

Gly Val Tyr Tyr Leu Asp Tyr 
1               5           


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  19

Arg Ala Ser Gln Gly Ile Arg Thr Asn Val Ala 
1               5                   10      


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  20

Ser Ala Ser Tyr Arg Gln Ser 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  21

Gly Val Tyr Tyr Phe Asp Glu 
1               5           


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  22

Arg Ala Ser Gln Gly Val Arg Thr Asn Leu Ala 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  23

Ala Ala Ser Ser Arg Gln Ser 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  24

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  25

Gln Gln Tyr Ala Asn Tyr Pro Arg Thr 
1               5                   


<210>  26
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  26

Met Gly Arg Ile Tyr Pro Ala Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  27

Gly Val Trp Tyr Tyr Asp Tyr 
1               5           


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR1


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Asp or Asn

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Tyr, His or Phe

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Met or Ile

<400>  28

Gly Tyr Thr Phe Thr Xaa Xaa Tyr Xaa Asn 
1               5                   10  


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Met or Ile

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Ser, Thr or Ala

<400>  29

Xaa Xaa Arg Ile Tyr Pro Xaa Xaa Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Tyr, Trp or Phe

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Tyr, Glu or His

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe, Tyr, Gln or Leu

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Asp, Gly, Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Tyr, Ala, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, 
       Pro, Gln, Arg, Ser, Thr or Val

<400>  30

Gly Val Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR1


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Asp or Asn

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Tyr or Phe

<400>  31

Gly Tyr Thr Phe Thr Xaa Xaa Tyr Met Asn 
1               5                   10  


<210>  32
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Met or Ile

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Gly or Ala

<400>  32

Xaa Gly Arg Ile Tyr Pro Xaa Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Tyr or Trp

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Tyr, Glu or His

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Tyr, Gln or Leu

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Tyr, Ser, Thr or Glu

<400>  33

Gly Val Xaa Xaa Xaa Asp Xaa 
1               5           


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ile or Val

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Thr or Asn

<400>  34

Arg Ala Ser Gln Gly Xaa Arg Xaa Asn Leu Ala 
1               5                   10      


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Ala, Ser or Tyr

<400>  35

Xaa Ala Ser Ser Leu Gln Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Asn, Ala, Ser, Glu or Thr

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser, Ala, Asn or Asp

<400>  36

Gln Gln Tyr Xaa Xaa Tyr Pro Arg Thr 
1               5                   


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Thr or Asn

<400>  37

Arg Ala Ser Gln Gly Ile Arg Xaa Asn Leu Ala 
1               5                   10      


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Asn or Ala

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser or Asn

<400>  38

Gln Gln Tyr Xaa Xaa Tyr Pro Arg Thr 
1               5                   


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  39

Arg Ala Ser Gln Gly Val Arg Thr Asn Val Ala 
1               5                   10      


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  40

Gly Val Trp Tyr Phe Asp Tyr 
1               5           


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  41

Gly Val Tyr Tyr Gln Asp Tyr 
1               5           


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  42

Gly Val Tyr Glu Phe Asp Tyr 
1               5           


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  43

Arg Ala Ser Gln Gly Val Arg Asn Asn Leu Ala 
1               5                   10      


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  44

Ala Ala Ser Tyr Arg Gln Ser 
1               5           


<210>  45
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  45

Ile Gly Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  46

Gly Val Tyr Tyr Phe Asp Ser 
1               5           


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  47

Arg Ala Ser Gln Gly Val Arg Asn Asn Val Ala 
1               5                   10      


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  48

Tyr Ala Ser Ser Leu Gln Ser 
1               5           


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  49

Gly Val Tyr His Phe Asp Tyr 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  50

Ala Ala Ser Tyr Leu Gln Ser 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  51

Gly Val Tyr Tyr Phe Asp Thr 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  52

Ser Ala Ser Ser Arg Gln Ser 
1               5           


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  53

Gln Gln Tyr Ala Ser Tyr Pro Arg Thr 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  54

Gln Gln Tyr Asn Ala Tyr Pro Arg Thr 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  55

Gln Gln Tyr Asn Asp Tyr Pro Arg Thr 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  56

Gln Gln Tyr Asn Ser Tyr Pro Lys Thr 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  57

Gln Gln Tyr Asn Ser Tyr Pro His Thr 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  58

Gln Gln Tyr Ser Ser Tyr Pro Arg Thr 
1               5                   


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  59

Gln Gln Tyr Glu Ser Tyr Pro Arg Thr 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  60

Gln Gln Tyr Thr Ser Tyr Pro Arg Thr 
1               5                   


<210>  61
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  61

Met Gly Arg Ile Tyr Pro Gly Thr Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  62

Gly Val Trp Tyr Phe Asp Ser 
1               5           


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  63

Gly Val Trp Tyr Phe Asp Thr 
1               5           


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TCED+ and HAF peptide

<400>  64

Val Thr Ile Thr Cys Lys Ala Ser Gln 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  light chain GE

<400>  65

Val Thr Ile Thr Cys Arg Ala Ser Gln 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HAF peptide

<400>  66

Leu Ile Tyr Ser Ala Ser Ser Leu Gln 
1               5                   


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HAF peptide

<400>  67

Ile Tyr Ser Ala Ser Ser Leu Gln Ser 
1               5                   


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TCED+ and HAF peptide

<400>  68

Tyr Tyr Ile Asn Trp Val Arg Gln Ala 
1               5                   


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR1

<400>  69

Asp Tyr Tyr Ile Asn 
1               5   


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR1

<400>  70

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR1

<400>  71

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  72
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR1

<400>  72

Thr Asp Tyr Tyr Ile Asn 
1               5       


<210>  73
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  73

Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  74

Tyr Pro Gly Ser Gly Asn 
1               5       


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  75

Ile Tyr Pro Gly Ser Gly Asn Thr 
1               5               


<210>  76
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  76

Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys Gly 
1               5                   10                  15      


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  77

Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr 
1               5                   10  


<210>  78
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  78

Ile Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr 
1               5                   10          


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  79

Ala Arg Gly Val Tyr Tyr Phe Asp Tyr 
1               5                   


<210>  80
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  80

Gly Val Tyr Tyr Phe Asp 
1               5       


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  81

Ala Arg Gly Val Tyr Tyr Phe Asp 
1               5               


<210>  82
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  82

Gln Asn Val Arg Thr Asn 
1               5       


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  83

Ala Ser Gln Asn Val Arg Thr Asn 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  84

Val Arg Thr Asn Val Ala Trp Tyr 
1               5               


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  85

Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr 
1               5                   10  


<210>  86
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  86

Tyr Asn Ser Tyr Pro Arg 
1               5       


<210>  87
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  87

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Val Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  88
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  h37M-VH

<400>  88

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Val Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  89
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VH graft

<400>  89

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  90
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  90

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  91
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  h37M-VL

<400>  91

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  92
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VL graft

<400>  92

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Arg Thr Asn 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  93

Arg Ala Ser Gln Gly Ile Arg Asn Asn Leu Ala 
1               5                   10      


<210>  94
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  94

Arg Ala Ser Gln Gly Ile Arg Asn Asn Val Ala 
1               5                   10      


<210>  95
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  95

Arg Ala Ser Gln Gly Ile Arg Asn Tyr Val Ala 
1               5                   10      


<210>  96
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  96

Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  97
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  97

Arg Ala Ser Gln Gly Ile Ser Asn Tyr Val Ala 
1               5                   10      


<210>  98
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  98

Arg Ala Ser Gln Gly Ile Ser Thr Asn Leu Ala 
1               5                   10      


<210>  99
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  99

Arg Ala Ser Gln Gly Ile Ser Thr Asn Val Ala 
1               5                   10      


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  100

Arg Ala Ser Gln Gly Ile Ser Thr Tyr Leu Ala 
1               5                   10      


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  101

Arg Ala Ser Gln Gly Ile Ser Thr Tyr Val Ala 
1               5                   10      


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  102

Arg Ala Ser Gln Gly Val Arg Asn Tyr Val Ala 
1               5                   10      


<210>  103
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  103

Arg Ala Ser Gln Gly Val Ser Asn Asn Leu Ala 
1               5                   10      


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  104

Arg Ala Ser Gln Gly Val Ser Asn Asn Val Ala 
1               5                   10      


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  105

Arg Ala Ser Gln Gly Val Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  106

Arg Ala Ser Gln Gly Val Ser Asn Tyr Val Ala 
1               5                   10      


<210>  107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  107

Arg Ala Ser Gln Gly Val Ser Thr Asn Leu Ala 
1               5                   10      


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  108

Arg Ala Ser Gln Gly Val Ser Thr Asn Val Ala 
1               5                   10      


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  109

Arg Ala Ser Gln Gly Val Ser Thr Tyr Leu Ala 
1               5                   10      


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR1

<400>  110

Arg Ala Ser Gln Gly Val Ser Thr Tyr Val Ala 
1               5                   10      


<210>  111
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  111

Ala Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  112

Ala Ala Ser Ser Arg Tyr Ser 
1               5           


<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  113

Ala Ala Ser Tyr Leu Tyr Ser 
1               5           


<210>  114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  114

Ala Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  115

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  116

Ser Ala Ser Ser Arg Tyr Ser 
1               5           


<210>  117
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  117

Ser Ala Ser Tyr Leu Gln Ser 
1               5           


<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR2

<400>  118

Ser Ala Ser Tyr Leu Tyr Ser 
1               5           


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  119

Gln Gln Tyr Ala Ser Tyr Pro Leu Thr 
1               5                   


<210>  120
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  120

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  121
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  121

Gln Gln Tyr Gln Ser Tyr Pro Leu Thr 
1               5                   


<210>  122
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  122

Gln Gln Tyr Gln Ser Tyr Pro Arg Thr 
1               5                   


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR1

<400>  123

Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His 
1               5                   10  


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR1

<400>  124

Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile Asn 
1               5                   10  


<210>  125
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR1

<400>  125

Gly Tyr Thr Phe Thr Ser Tyr Tyr Met Asn 
1               5                   10  


<210>  126
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  126

Ile Ala Ile Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  127
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  127

Ile Ala Arg Ile Asn Pro Gly Ser Gly Asn Thr Ser Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  128
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  128

Ile Ala Arg Ile Asn Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  129
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  129

Ile Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Ser Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  130
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  130

Ile Ala Arg Ile Tyr Pro Ser Ser Gly Asn Thr Ser Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  131
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  131

Ile Ala Arg Ile Tyr Pro Ser Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  132
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  132

Ile Gly Ile Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  133
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  133

Ile Gly Arg Ile Asn Pro Gly Ser Gly Asn Thr Ser Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  134
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  134

Ile Gly Arg Ile Asn Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  135
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  135

Ile Gly Arg Ile Tyr Pro Gly Ser Gly Asn Thr Ser Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  136
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  136

Ile Gly Arg Ile Tyr Pro Ser Ser Gly Asn Thr Ser Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  137
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  137

Ile Gly Arg Ile Tyr Pro Ser Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  138
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  138

Met Ala Ile Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  139
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  139

Met Ala Arg Ile Asn Pro Gly Ser Gly Asn Thr Ser Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  140
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  140

Met Ala Arg Ile Asn Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  141
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  141

Met Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Ser Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  142
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  142

Met Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  143
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  143

Met Ala Arg Ile Tyr Pro Ser Ser Gly Asn Thr Ser Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  144
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  144

Met Ala Arg Ile Tyr Pro Ser Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  145
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  145

Met Gly Ile Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  146
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  146

Met Gly Arg Ile Asn Pro Gly Ser Gly Asn Thr Ser Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  147
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  147

Met Gly Arg Ile Asn Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  148
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  148

Met Gly Arg Ile Tyr Pro Gly Ser Gly Asn Thr Ser Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  149
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  149

Met Gly Arg Ile Tyr Pro Ser Ser Gly Asn Thr Ser Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  150
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  150

Met Gly Arg Ile Tyr Pro Ser Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  151
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  151

Gly Val Tyr Tyr Phe Asp Ala 
1               5           


<210>  152
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  152

Gly Val Tyr Tyr Phe Asp Asp 
1               5           


<210>  153
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  153

Gly Val Tyr Tyr Phe Asp Phe 
1               5           


<210>  154
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  154

Gly Val Tyr Tyr Phe Asp Gly 
1               5           


<210>  155
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  155

Gly Val Tyr Tyr Phe Asp His 
1               5           


<210>  156
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  156

Gly Val Tyr Tyr Phe Asp Ile 
1               5           


<210>  157
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  157

Gly Val Tyr Tyr Phe Asp Lys 
1               5           


<210>  158
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  158

Gly Val Tyr Tyr Phe Asp Met 
1               5           


<210>  159
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  159

Gly Val Tyr Tyr Phe Asp Asn 
1               5           


<210>  160
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  160

Gly Val Tyr Tyr Phe Asp Pro 
1               5           


<210>  161
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  161

Gly Val Tyr Tyr Phe Asp Gln 
1               5           


<210>  162
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  162

Gly Val Tyr Tyr Phe Asp Arg 
1               5           


<210>  163
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  163

Gly Val Tyr Tyr Phe Asp Val 
1               5           


<210>  164
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  164

Gly Val Tyr Tyr Phe Asp Trp 
1               5           


<210>  165
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  165

Gly Val Tyr Tyr Ala Asp Tyr 
1               5           


<210>  166
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  166

Gly Val Tyr Tyr Gly Asp Tyr 
1               5           


<210>  167
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  167

Gly Val Tyr Tyr His Asp Tyr 
1               5           


<210>  168
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  168

Gly Val Tyr Tyr Lys Asp Tyr 
1               5           


<210>  169
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  169

Gly Val Tyr Tyr Asn Asp Tyr 
1               5           


<210>  170
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  170

Gly Val Tyr Tyr Met Asp Tyr 
1               5           


<210>  171
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  171

Gly Val Tyr Tyr Trp Asp Tyr 
1               5           


<210>  172
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  172

Gly Val Tyr Ala Phe Asp Tyr 
1               5           


<210>  173
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  173

Gly Val Tyr Gln Phe Asp Tyr 
1               5           


<210>  174
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  174

Gly Val Tyr Trp Phe Asp Tyr 
1               5           


<210>  175
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  175

Gly Val Tyr Asn Phe Asp Tyr 
1               5           


<210>  176
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  176

Gly Val Tyr Thr Phe Asp Tyr 
1               5           


<210>  177
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  177

Gly Val Tyr Asp Phe Asp Tyr 
1               5           


<210>  178
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  178

Gln Gln Tyr Asn Ala Tyr Pro Lys Thr 
1               5                   


<210>  179
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  179

Gln Gln Tyr Asn Ala Tyr Pro His Thr 
1               5                   


<210>  180
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR1

<400>  180

Gly Tyr Thr Phe Thr Asp Phe Tyr Met Asn 
1               5                   10  


<210>  181
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR1

<400>  181

Gly Tyr Thr Phe Thr Asn Tyr Tyr Met Asn 
1               5                   10  


<210>  182
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR1

<400>  182

Gly Tyr Thr Phe Thr Asp His Tyr Met Asn 
1               5                   10  


<210>  183
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  183

Met Gly Arg Ile Tyr Pro Gly Ala Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  184
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  184

Gly Val Trp Tyr Phe Asp Glu 
1               5           


<210>  185
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody MH1 heavy chain variable (VH) region

<400>  185

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Tyr Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  186
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody MH1 VL light chain variable (VL) region

<400>  186

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Thr Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  187
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody MH5-DI heavy chain variable (VH) region

<400>  187

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Tyr Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  188
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody MH5-DI light chain variable (VL) region

<400>  188

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Thr Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Asn Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  189
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody MH5 heavy chain variable (VH) region

<400>  189

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Tyr Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  190
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody MH5 light chain variable (VL) region

<400>  190

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Thr Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Asn Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  191
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody EC7 heavy chain variable (VH) region

<400>  191

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Tyr Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  192
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody EC7 light chain variable (VL) region

<400>  192

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Thr Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  193
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody EC2 heavy chain variable (VH) region

<400>  193

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Tyr Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  194
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody EC2 light chain variable (VL) region

<400>  194

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Thr Asn 
            20                  25                  30          


Val Ala Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  195
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody F-C5 heavy chain variable (VH) region

<400>  195

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Tyr Tyr Phe Asp Glu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  196
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody F-C5 light chain variable (VL) region

<400>  196

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Arg Thr Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Arg Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  197
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  197

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  198
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  198

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  199
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  199

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  200
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  200

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  201
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  201

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330                 


<210>  202
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  202

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  203
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  203

Arg Asp Glu Leu Thr 
1               5   


<210>  204
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  204

Arg Glu Glu Met 
1               


<210>  205
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR3

<400>  205

Gly Val Tyr Tyr Phe Asp Leu 
1               5           


<210>  206
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT HCDR2

<400>  206

Ile Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Gln Gly 
            

<210>  207
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-C-KIT LCDR3

<400>  207

Gln Gln Tyr Asn Ser Tyr Pro Arg 
1               5                   


<210>  208
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Ile Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala His Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


<210>  209
<211>  5190
<212>  DNA
<213>  Homo sapiens

<400>  209
tctgggggct cggctttgcc gcgctcgctg cacttgggcg agagctggaa cgtggaccag       60

agctcggatc ccatcgcagc taccgcgatg agaggcgctc gcggcgcctg ggattttctc      120

tgcgttctgc tcctactgct tcgcgtccag acaggctctt ctcaaccatc tgtgagtcca      180

ggggaaccgt ctccaccatc catccatcca ggaaaatcag acttaatagt ccgcgtgggc      240

gacgagatta ggctgttatg cactgatccg ggctttgtca aatggacttt tgagatcctg      300

gatgaaacga atgagaataa gcagaatgaa tggatcacgg aaaaggcaga agccaccaac      360

accggcaaat acacgtgcac caacaaacac ggcttaagca attccattta tgtgtttgtt      420

agagatcctg ccaagctttt ccttgttgac cgctccttgt atgggaaaga agacaacgac      480

acgctggtcc gctgtcctct cacagaccca gaagtgacca attattccct caaggggtgc      540

caggggaagc ctcttcccaa ggacttgagg tttattcctg accccaaggc gggcatcatg      600

atcaaaagtg tgaaacgcgc ctaccatcgg ctctgtctgc attgttctgt ggaccaggag      660

ggcaagtcag tgctgtcgga aaaattcatc ctgaaagtga ggccagcctt caaagctgtg      720

cctgttgtgt ctgtgtccaa agcaagctat cttcttaggg aaggggaaga attcacagtg      780

acgtgcacaa taaaagatgt gtctagttct gtgtactcaa cgtggaaaag agaaaacagt      840

cagactaaac tacaggagaa atataatagc tggcatcacg gtgacttcaa ttatgaacgt      900

caggcaacgt tgactatcag ttcagcgaga gttaatgatt ctggagtgtt catgtgttat      960

gccaataata cttttggatc agcaaatgtc acaacaacct tggaagtagt agataaagga     1020

ttcattaata tcttccccat gataaacact acagtatttg taaacgatgg agaaaatgta     1080

gatttgattg ttgaatatga agcattcccc aaacctgaac accagcagtg gatctatatg     1140

aacagaacct tcactgataa atgggaagat tatcccaagt ctgagaatga aagtaatatc     1200

agatacgtaa gtgaacttca tctaacgaga ttaaaaggca ccgaaggagg cacttacaca     1260

ttcctagtgt ccaattctga cgtcaatgct gccatagcat ttaatgttta tgtgaataca     1320

aaaccagaaa tcctgactta cgacaggctc gtgaatggca tgctccaatg tgtggcagca     1380

ggattcccag agcccacaat agattggtat ttttgtccag gaactgagca gagatgctct     1440

gcttctgtac tgccagtgga tgtgcagaca ctaaactcat ctgggccacc gtttggaaag     1500

ctagtggttc agagttctat agattctagt gcattcaagc acaatggcac ggttgaatgt     1560

aaggcttaca acgatgtggg caagacttct gcctatttta actttgcatt taaaggtaac     1620

aacaaagagc aaatccatcc ccacaccctg ttcactcctt tgctgattgg tttcgtaatc     1680

gtagctggca tgatgtgcat tattgtgatg attctgacct acaaatattt acagaaaccc     1740

atgtatgaag tacagtggaa ggttgttgag gagataaatg gaaacaatta tgtttacata     1800

gacccaacac aacttcctta tgatcacaaa tgggagtttc ccagaaacag gctgagtttt     1860

gggaaaaccc tgggtgctgg agctttcggg aaggttgttg aggcaactgc ttatggctta     1920

attaagtcag atgcggccat gactgtcgct gtaaagatgc tcaagccgag tgcccatttg     1980

acagaacggg aagccctcat gtctgaactc aaagtcctga gttaccttgg taatcacatg     2040

aatattgtga atctacttgg agcctgcacc attggagggc ccaccctggt cattacagaa     2100

tattgttgct atggtgatct tttgaatttt ttgagaagaa aacgtgattc atttatttgt     2160

tcaaagcagg aagatcatgc agaagctgca ctttataaga atcttctgca ttcaaaggag     2220

tcttcctgca gcgatagtac taatgagtac atggacatga aacctggagt ttcttatgtt     2280

gtcccaacca aggccgacaa aaggagatct gtgagaatag gctcatacat agaaagagat     2340

gtgactcccg ccatcatgga ggatgacgag ttggccctag acttagaaga cttgctgagc     2400

ttttcttacc aggtggcaaa gggcatggct ttcctcgcct ccaagaattg tattcacaga     2460

gacttggcag ccagaaatat cctccttact catggtcgga tcacaaagat ttgtgatttt     2520

ggtctagcca gagacatcaa gaatgattct aattatgtgg ttaaaggaaa cgctcgacta     2580

cctgtgaagt ggatggcacc tgaaagcatt ttcaactgtg tatacacgtt tgaaagtgac     2640

gtctggtcct atgggatttt tctttgggag ctgttctctt taggaagcag cccctatcct     2700

ggaatgccgg tcgattctaa gttctacaag atgatcaagg aaggcttccg gatgctcagc     2760

cctgaacacg cacctgctga aatgtatgac ataatgaaga cttgctggga tgcagatccc     2820

ctaaaaagac caacattcaa gcaaattgtt cagctaattg agaagcagat ttcagagagc     2880

accaatcata tttactccaa cttagcaaac tgcagcccca accgacagaa gcccgtggta     2940

gaccattctg tgcggatcaa ttctgtcggc agcaccgctt cctcctccca gcctctgctt     3000

gtgcacgacg atgtctgagc agaatcagtg tttgggtcac ccctccagga atgatctctt     3060

cttttggctt ccatgatggt tattttcttt tctttcaact tgcatccaac tccaggatag     3120

tgggcacccc actgcaatcc tgtctttctg agcacacttt agtggccgat gatttttgtc     3180

atcagccacc atcctattgc aaaggttcca actgtatata ttcccaatag caacgtagct     3240

tctaccatga acagaaaaca ttctgatttg gaaaaagaga gggaggtatg gactgggggc     3300

cagagtcctt tccaaggctt ctccaattct gcccaaaaat atggttgata gtttacctga     3360

ataaatggta gtaatcacag ttggccttca gaaccatcca tagtagtatg atgatacaag     3420

attagaagct gaaaacctaa gtcctttatg tggaaaacag aacatcatta gaacaaagga     3480

cagagtatga acacctgggc ttaagaaatc tagtatttca tgctgggaat gagacatagg     3540

ccatgaaaaa aatgatcccc aagtgtgaac aaaagatgct cttctgtgga ccactgcatg     3600

agcttttata ctaccgacct ggtttttaaa tagagtttgc tattagagca ttgaattgga     3660

gagaaggcct ccctagccag cacttgtata tacgcatcta taaattgtcc gtgttcatac     3720

atttgagggg aaaacaccat aaggtttcgt ttctgtatac aaccctggca ttatgtccac     3780

tgtgtataga agtagattaa gagccatata agtttgaagg aaacagttaa taccattttt     3840

taaggaaaca atataaccac aaagcacagt ttgaacaaaa tctcctcttt tagctgatga     3900

acttattctg tagattctgt ggaacaagcc tatcagcttc agaatggcat tgtactcaat     3960

ggatttgatg ctgtttgaca aagttactga ttcactgcat ggctcccaca ggagtgggaa     4020

aacactgcca tcttagtttg gattcttatg tagcaggaaa taaagtatag gtttagcctc     4080

cttcgcaggc atgtcctgga caccgggcca gtatctatat atgtgtatgt acgtttgtat     4140

gtgtgtagac aaatatttgg aggggtattt ttgccctgag tccaagaggg tcctttagta     4200

cctgaaaagt aacttggctt tcattattag tactgctctt gtttcttttc acatagctgt     4260

ctagagtagc ttaccagaag cttccatagt ggtgcagagg aagtggaagg catcagtccc     4320

tatgtatttg cagttcacct gcacttaagg cactctgtta tttagactca tcttactgta     4380

cctgttcctt agaccttcca taatgctact gtctcactga aacatttaaa ttttaccctt     4440

tagactgtag cctggatatt attcttgtag tttacctctt taaaaacaaa acaaaacaaa     4500

acaaaaaact ccccttcctc actgcccaat ataaaaggca aatgtgtaca tggcagagtt     4560

tgtgtgttgt cttgaaagat tcaggtatgt tgcctttatg gtttccccct tctacatttc     4620

ttagactaca tttagagaac tgtggccgtt atctggaagt aaccatttgc actggagttc     4680

tatgctctcg cacctttcca aagttaacag attttggggt tgtgttgtca cccaagagat     4740

tgttgtttgc catactttgt ctgaaaaatt cctttgtgtt tctattgact tcaatgatag     4800

taagaaaagt ggttgttagt tatagatgtc taggtacttc aggggcactt cattgagagt     4860

tttgtcttgg atattcttga aagtttatat ttttataatt ttttcttaca tcagatgttt     4920

ctttgcagtg gcttaatgtt tgaaattatt ttgtggcttt ttttgtaaat attgaaatgt     4980

agcaataatg tcttttgaat attcccaagc ccatgagtcc ttgaaaatat tttttatata     5040

tacagtaact ttatgtgtaa atacataagc ggcgtaagtt taaaggatgt tggtgttcca     5100

cgtgttttat tcctgtatgt tgtccaattg ttgacagttc tgaagaattc taataaaatg     5160

tacatatata aatcaaaaaa aaaaaaaaaa                                      5190


<210>  210
<211>  5178
<212>  DNA
<213>  Homo sapiens

<400>  210
tctgggggct cggctttgcc gcgctcgctg cacttgggcg agagctggaa cgtggaccag       60

agctcggatc ccatcgcagc taccgcgatg agaggcgctc gcggcgcctg ggattttctc      120

tgcgttctgc tcctactgct tcgcgtccag acaggctctt ctcaaccatc tgtgagtcca      180

ggggaaccgt ctccaccatc catccatcca ggaaaatcag acttaatagt ccgcgtgggc      240

gacgagatta ggctgttatg cactgatccg ggctttgtca aatggacttt tgagatcctg      300

gatgaaacga atgagaataa gcagaatgaa tggatcacgg aaaaggcaga agccaccaac      360

accggcaaat acacgtgcac caacaaacac ggcttaagca attccattta tgtgtttgtt      420

agagatcctg ccaagctttt ccttgttgac cgctccttgt atgggaaaga agacaacgac      480

acgctggtcc gctgtcctct cacagaccca gaagtgacca attattccct caaggggtgc      540

caggggaagc ctcttcccaa ggacttgagg tttattcctg accccaaggc gggcatcatg      600

atcaaaagtg tgaaacgcgc ctaccatcgg ctctgtctgc attgttctgt ggaccaggag      660

ggcaagtcag tgctgtcgga aaaattcatc ctgaaagtga ggccagcctt caaagctgtg      720

cctgttgtgt ctgtgtccaa agcaagctat cttcttaggg aaggggaaga attcacagtg      780

acgtgcacaa taaaagatgt gtctagttct gtgtactcaa cgtggaaaag agaaaacagt      840

cagactaaac tacaggagaa atataatagc tggcatcacg gtgacttcaa ttatgaacgt      900

caggcaacgt tgactatcag ttcagcgaga gttaatgatt ctggagtgtt catgtgttat      960

gccaataata cttttggatc agcaaatgtc acaacaacct tggaagtagt agataaagga     1020

ttcattaata tcttccccat gataaacact acagtatttg taaacgatgg agaaaatgta     1080

gatttgattg ttgaatatga agcattcccc aaacctgaac accagcagtg gatctatatg     1140

aacagaacct tcactgataa atgggaagat tatcccaagt ctgagaatga aagtaatatc     1200

agatacgtaa gtgaacttca tctaacgaga ttaaaaggca ccgaaggagg cacttacaca     1260

ttcctagtgt ccaattctga cgtcaatgct gccatagcat ttaatgttta tgtgaataca     1320

aaaccagaaa tcctgactta cgacaggctc gtgaatggca tgctccaatg tgtggcagca     1380

ggattcccag agcccacaat agattggtat ttttgtccag gaactgagca gagatgctct     1440

gcttctgtac tgccagtgga tgtgcagaca ctaaactcat ctgggccacc gtttggaaag     1500

ctagtggttc agagttctat agattctagt gcattcaagc acaatggcac ggttgaatgt     1560

aaggcttaca acgatgtggg caagacttct gcctatttta actttgcatt taaagagcaa     1620

atccatcccc acaccctgtt cactcctttg ctgattggtt tcgtaatcgt agctggcatg     1680

atgtgcatta ttgtgatgat tctgacctac aaatatttac agaaacccat gtatgaagta     1740

cagtggaagg ttgttgagga gataaatgga aacaattatg tttacataga cccaacacaa     1800

cttccttatg atcacaaatg ggagtttccc agaaacaggc tgagttttgg gaaaaccctg     1860

ggtgctggag ctttcgggaa ggttgttgag gcaactgctt atggcttaat taagtcagat     1920

gcggccatga ctgtcgctgt aaagatgctc aagccgagtg cccatttgac agaacgggaa     1980

gccctcatgt ctgaactcaa agtcctgagt taccttggta atcacatgaa tattgtgaat     2040

ctacttggag cctgcaccat tggagggccc accctggtca ttacagaata ttgttgctat     2100

ggtgatcttt tgaatttttt gagaagaaaa cgtgattcat ttatttgttc aaagcaggaa     2160

gatcatgcag aagctgcact ttataagaat cttctgcatt caaaggagtc ttcctgcagc     2220

gatagtacta atgagtacat ggacatgaaa cctggagttt cttatgttgt cccaaccaag     2280

gccgacaaaa ggagatctgt gagaataggc tcatacatag aaagagatgt gactcccgcc     2340

atcatggagg atgacgagtt ggccctagac ttagaagact tgctgagctt ttcttaccag     2400

gtggcaaagg gcatggcttt cctcgcctcc aagaattgta ttcacagaga cttggcagcc     2460

agaaatatcc tccttactca tggtcggatc acaaagattt gtgattttgg tctagccaga     2520

gacatcaaga atgattctaa ttatgtggtt aaaggaaacg ctcgactacc tgtgaagtgg     2580

atggcacctg aaagcatttt caactgtgta tacacgtttg aaagtgacgt ctggtcctat     2640

gggatttttc tttgggagct gttctcttta ggaagcagcc cctatcctgg aatgccggtc     2700

gattctaagt tctacaagat gatcaaggaa ggcttccgga tgctcagccc tgaacacgca     2760

cctgctgaaa tgtatgacat aatgaagact tgctgggatg cagatcccct aaaaagacca     2820

acattcaagc aaattgttca gctaattgag aagcagattt cagagagcac caatcatatt     2880

tactccaact tagcaaactg cagccccaac cgacagaagc ccgtggtaga ccattctgtg     2940

cggatcaatt ctgtcggcag caccgcttcc tcctcccagc ctctgcttgt gcacgacgat     3000

gtctgagcag aatcagtgtt tgggtcaccc ctccaggaat gatctcttct tttggcttcc     3060

atgatggtta ttttcttttc tttcaacttg catccaactc caggatagtg ggcaccccac     3120

tgcaatcctg tctttctgag cacactttag tggccgatga tttttgtcat cagccaccat     3180

cctattgcaa aggttccaac tgtatatatt cccaatagca acgtagcttc taccatgaac     3240

agaaaacatt ctgatttgga aaaagagagg gaggtatgga ctgggggcca gagtcctttc     3300

caaggcttct ccaattctgc ccaaaaatat ggttgatagt ttacctgaat aaatggtagt     3360

aatcacagtt ggccttcaga accatccata gtagtatgat gatacaagat tagaagctga     3420

aaacctaagt cctttatgtg gaaaacagaa catcattaga acaaaggaca gagtatgaac     3480

acctgggctt aagaaatcta gtatttcatg ctgggaatga gacataggcc atgaaaaaaa     3540

tgatccccaa gtgtgaacaa aagatgctct tctgtggacc actgcatgag cttttatact     3600

accgacctgg tttttaaata gagtttgcta ttagagcatt gaattggaga gaaggcctcc     3660

ctagccagca cttgtatata cgcatctata aattgtccgt gttcatacat ttgaggggaa     3720

aacaccataa ggtttcgttt ctgtatacaa ccctggcatt atgtccactg tgtatagaag     3780

tagattaaga gccatataag tttgaaggaa acagttaata ccatttttta aggaaacaat     3840

ataaccacaa agcacagttt gaacaaaatc tcctctttta gctgatgaac ttattctgta     3900

gattctgtgg aacaagccta tcagcttcag aatggcattg tactcaatgg atttgatgct     3960

gtttgacaaa gttactgatt cactgcatgg ctcccacagg agtgggaaaa cactgccatc     4020

ttagtttgga ttcttatgta gcaggaaata aagtataggt ttagcctcct tcgcaggcat     4080

gtcctggaca ccgggccagt atctatatat gtgtatgtac gtttgtatgt gtgtagacaa     4140

atatttggag gggtattttt gccctgagtc caagagggtc ctttagtacc tgaaaagtaa     4200

cttggctttc attattagta ctgctcttgt ttcttttcac atagctgtct agagtagctt     4260

accagaagct tccatagtgg tgcagaggaa gtggaaggca tcagtcccta tgtatttgca     4320

gttcacctgc acttaaggca ctctgttatt tagactcatc ttactgtacc tgttccttag     4380

accttccata atgctactgt ctcactgaaa catttaaatt ttacccttta gactgtagcc     4440

tggatattat tcttgtagtt tacctcttta aaaacaaaac aaaacaaaac aaaaaactcc     4500

ccttcctcac tgcccaatat aaaaggcaaa tgtgtacatg gcagagtttg tgtgttgtct     4560

tgaaagattc aggtatgttg cctttatggt ttcccccttc tacatttctt agactacatt     4620

tagagaactg tggccgttat ctggaagtaa ccatttgcac tggagttcta tgctctcgca     4680

cctttccaaa gttaacagat tttggggttg tgttgtcacc caagagattg ttgtttgcca     4740

tactttgtct gaaaaattcc tttgtgtttc tattgacttc aatgatagta agaaaagtgg     4800

ttgttagtta tagatgtcta ggtacttcag gggcacttca ttgagagttt tgtcttggat     4860

attcttgaaa gtttatattt ttataatttt ttcttacatc agatgtttct ttgcagtggc     4920

ttaatgtttg aaattatttt gtggcttttt ttgtaaatat tgaaatgtag caataatgtc     4980

ttttgaatat tcccaagccc atgagtcctt gaaaatattt tttatatata cagtaacttt     5040

atgtgtaaat acataagcgg cgtaagttta aaggatgttg gtgttccacg tgttttattc     5100

ctgtatgttg tccaattgtt gacagttctg aagaattcta ataaaatgta catatataaa     5160

tcaaaaaaaa aaaaaaaa                                                   5178


