                         SEQUENCE LISTING

<110>  CONSEJO NACIONAL DE INVESTIGACIONES CIENTFICAS Y TCNICAS
(CONICET) - UNIVERSIDAD NACIONAL DE GENERAL SAN MARTN - JULIANA 
CASSATARO
 
<120>  IMMUNOMODULATING AND IMMUNOSTIMULATING POLYPEPTIDES FOR 
       DRUG-DELIVERY

<130>  P4477PC00

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Ecotin from Salmonella enterica without signal peptide

<400>  1

Met Ala Asn Asn Gly Asp Thr Ala Gln Pro Leu Glu Lys Ile Ala Pro 
1               5                   10                  15      


Tyr Pro Gln Ala Glu Lys Gly Met Lys Arg Gln Val Ile Thr Leu Thr 
            20                  25                  30          


Pro Gln Gln Asp Glu Ser Thr Leu Lys Val Glu Leu Leu Ile Gly Gln 
        35                  40                  45              


Thr Leu Asn Val Asp Cys Asn Gln His Arg Leu Gly Gly Thr Leu Glu 
    50                  55                  60                  


Thr Lys Thr Leu Glu Gly Trp Gly Tyr Asp Tyr Tyr Val Phe Asp Asn 
65                  70                  75                  80  


Val Thr Ser Pro Val Ser Thr Met Met Ala Cys Pro Glu Gly Lys Lys 
                85                  90                  95      


Glu Gln Lys Phe Val Thr Ala Trp Leu Gly Glu Asp Gly Met Leu Arg 
            100                 105                 110         


Tyr Asn Ser Lys Leu Pro Ile Val Val Tyr Thr Pro Ala Asn Val Asp 
        115                 120                 125             


Val Lys Tyr Arg Ile Trp Lys Ala Asp Ala Asn Val Gln Asn Ala Val 
    130                 135                 140                 


Ala Arg Leu Glu His His His His His His 
145                 150                 


<210>  2
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified aprin from Pseudomonas aeruginosa without signal peptide

<400>  2

Met Ala Ser Ser Leu Ile Leu Leu Ser Ala Ser Asp Leu Ala Gly Gln 
1               5                   10                  15      


Trp Thr Leu Gln Gln Asp Glu Ala Pro Ala Ile Cys His Leu Glu Leu 
            20                  25                  30          


Arg Asp Ser Glu Val Ala Glu Ala Ser Gly Tyr Asp Leu Gly Gly Asp 
        35                  40                  45              


Thr Ala Cys Leu Thr Arg Trp Leu Pro Ser Glu Pro Arg Ala Trp Arg 
    50                  55                  60                  


Pro Thr Pro Ala Gly Ile Ala Leu Leu Glu Arg Gly Gly Leu Thr Leu 
65                  70                  75                  80  


Met Leu Leu Gly Arg Gln Gly Glu Gly Asp Tyr Arg Val Gln Lys Gly 
                85                  90                  95      


Asp Gly Gly Gln Leu Val Leu Arg Arg Ala Thr Pro Leu Glu His His 
            100                 105                 110         


His His His His 
        115     


<210>  3
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Staphostatin B from Staphylococcus aureus

<400>  3

Met His His His His His His Tyr Gln Leu Gln Phe Ile Asn Leu Val 
1               5                   10                  15      


Tyr Asp Thr Thr Lys Leu Thr His Leu Glu Gln Thr Asn Ile Asn Leu 
            20                  25                  30          


Phe Ile Gly Asn Trp Ser Asn His Gln Leu Gln Lys Ser Ile Cys Ile 
        35                  40                  45              


Arg His Gly Asp Asp Thr Ser His Asn Gln Tyr His Ile Leu Phe Ile 
    50                  55                  60                  


Asp Thr Ala His Gln Arg Ile Lys Phe Ser Ser Ile Asp Asn Glu Glu 
65                  70                  75                  80  


Ile Ile Tyr Ile Leu Asp Tyr Asp Asp Thr Gln His Ile Leu Met Gln 
                85                  90                  95      


Thr Ser Ser Lys Gln Gly Ile Gly Thr Ser Arg Pro Ile Val Tyr Glu 
            100                 105                 110         


Arg Leu Val 
        115 


<210>  4
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Staphostatin A from Staphylococcus aureus

<400>  4

Met His His His His His His Glu Gln Phe Glu Leu Phe Ser Ile Asp 
1               5                   10                  15      


Lys Phe Lys Cys Asn Ser Glu Ala Lys Tyr Tyr Leu Asn Ile Ile Glu 
            20                  25                  30          


Gly Glu Trp His Pro Gln Asp Leu Asn Asp Ser Pro Leu Lys Phe Ile 
        35                  40                  45              


Leu Ser Thr Ser Asp Asp Ser Asp Tyr Ile Cys Lys Tyr Ile Asn Thr 
    50                  55                  60                  


Glu His Lys Gln Leu Thr Leu Tyr Asn Lys Asn Asn Ser Ser Ile Val 
65                  70                  75                  80  


Ile Glu Ile Phe Ile Pro Asn Asp Asn Lys Ile Leu Leu Thr Ile Met 
                85                  90                  95      


Asn Ile Glu Ala Leu Gly Thr Ser Pro Arg Met Thr Phe Ile Lys His 
            100                 105                 110         


Lys Ser 
        


<210>  5
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified serine carboxypeptidase Y inh. from Helicobacter pylori

<400>  5

Met Lys Thr Phe Glu Val Met Ile Gln Thr Asp Ser Glu Gly Tyr Leu 
1               5                   10                  15      


Asp Ala Lys Phe Gly Gly Asn Ala Pro Arg Gly Phe Leu Asn Pro Asn 
            20                  25                  30          


Gly Leu Pro Thr Tyr Ser Pro Lys Ile Ser Trp Gln Lys Val Glu Gly 
        35                  40                  45              


Ala Gln Ser Tyr Ala Leu Glu Leu Ile Asp His Asp Ala Gln Lys Val 
    50                  55                  60                  


Cys Gly Met Ser Phe Ile His Trp Val Val Gly Asn Ile Ser His Asn 
65                  70                  75                  80  


Val Leu Glu Glu Asn Ala Ser Met Met Asp Lys Arg Ile Thr Gln Gly 
                85                  90                  95      


Val Asn Ser Leu Thr Gln Gly Phe Ile Arg Ser Pro Leu Asn Glu Ser 
            100                 105                 110         


Glu Lys Gln Arg Ser Asn Leu Asn Asn Ser Val Tyr Ile Gly Pro Met 
        115                 120                 125             


Pro Pro Asn Gly Asp His His Tyr Leu Ile Gln Val Tyr Ala Leu Asp 
    130                 135                 140                 


Ile Pro Lys Leu Ala Leu Lys Ala Pro Phe Phe Leu Gly Asp Leu His 
145                 150                 155                 160 


Asp Lys Met Arg Asn His Ile Ile Ala Ile Gly Arg Lys Glu Phe Leu 
                165                 170                 175     


Tyr Lys Gln Phe Met Arg Lys Leu Glu His His His His His His 
            180                 185                 190     


<210>  6
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding modified Ecotin from Salmonella 
       without signal peptide

<400>  6
catatggcta acaatggcga taccgcccag ccgctggaaa aaatcgcccc ctatccgcag       60

gcggaaaaag gaatgaagcg gcaagtgata acccttaccc ctcagcagga tgaatctacc      120

ctcaaagtgg aactgttgat tggccaaacg ctgaatgtgg attgtaacca gcatcgcctc      180

ggcggcacgc tggaaacaaa aacgctggaa ggctggggct atgactatta tgtctttgat      240

aacgtcacct ctccggtatc aaccatgatg gcctgccctg aaggtaagaa agagcaaaaa      300

ttcgtcaccg cctggctggg tgaagacggg atgctgcgct acaacagcaa gctgccgatc      360

gtggtgtata ccccggcgaa tgtggacgtg aaataccgca tctggaaagc ggacgctaac      420

gtacagaacg ccgtcgcgcg actcgag                                          447


<210>  7
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide encoding modified aprin from Pseudomonas aeruginosa 
       (without signal peptide)

<400>  7
catatggcca gcagtctgat tcttctcagc gcttccgatc tcgccgggca atggaccctg       60

cagcaggacg aggcgcccgc gatctgccac ctggagctgc gcgacagcga agtggcggaa      120

gccagtggct acgacctggg cggcgatacc gcctgcctca cgcgctggct gcccagcgag      180

ccgcgcgcct ggaggcctac cccggccggg atcgcgctgc tcgaacgcgg cggcctgacc      240

ctgatgctcc tcggtcgcca gggcgagggc gactaccggg tgcagaaggg cgacggcggg      300

cagttggtgc tgcgccgcgc gacgcccctc gag                                   333


<210>  8
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide encoding modified staphostatin B from Staphylococcus 
       aureus

<400>  8
catatgcacc accaccacca ccactatcaa ctacaattta taaatttagt ttacgacaca       60

accaaactca cacatctaga acaaaccaat atcaatttat tcattggtaa ttggagtaat      120

catcaattac aaaaatcaat ttgtatacgt catggcgatg atacaagtca caatcaatat      180

catattcttt ttatagatac ggcacatcaa cgcattaaat tttcatctat tgataatgaa      240

gaaatcattt atattcttga ttatgatgat acacagcata tcctcatgca aacgtcatcc      300

aaacaaggta ttggcacttc gcgcccaatc gtttatgagc gcttagtata actcgag         357


<210>  9
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide encoding modified staphostatin A from Staphylococcus 
       aureus

<400>  9
catatgcacc accaccacca ccacgaacaa tttgaattat ttagtattga taaattcaaa       60

tgtaattcag aggctaagta ttatcttaat attattgagg gagaatggca tcctcaagat      120

ttaaatgata gccctttaaa atttattctc agtacctcag acgattctga ttacatttgc      180

aaatatataa atacagaaca caaacaactc acattatata ataaaaataa tagctcaatt      240

gttattgaaa tatttatacc aaatgataat aaaatactac taacaattat gaacatagaa      300

gctttaggaa cttctcctag aatgactttc attaagcata aaagttaact cgag            354


<210>  10
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide encoding modified serine carboxypeptidase Y inhibitor 
       from Helicobacter pylori

<400>  10
catatgaaaa cttttgaagt gatgattcaa accgattcag aagggtattt ggacgctaaa       60

tttggcggta acgctcctag agggtttctc aatccaaacg gcttacccac ttattcgcct      120

aaaatctcat ggcaaaaagt agaaggtgct caaagctatg cgttagaact tattgatcat      180

gacgcgcaaa aagtgtgcgg catgtcgttt atccattggg tcgtgggcaa tatctctcat      240

aatgttttag aagaaaacgc ctccatgatg gataaaagga ttactcaagg ggtcaattcg      300

cttactcaag gctttatccg ttctcctctt aatgaaagcg aaaaacaacg ctccaatctc      360

aataacagcg tctatatcgg ccccatgcct cctaatggcg atcaccatta cttgattcaa      420

gtgtatgccc tagacattcc taaactcgcc ttaaaagccc cttttttctt aggcgatttg      480

catgacaaaa tgcgcaacca tatcatcgcc atagggagaa aggaatttct atacaagcag      540

tttatgagga aactcgag                                                    558


