                         SEQUENCE LISTING

<110>  Fast Forward Pharmaceuticals B.V.
 
<120>  Improved antagonistic anti-human CD40 monoclonal antibodies

<130>  P115857PC00

<140>  PCT/NL2019/050086
<141>  2019-02-11

<150>  EP 18156288.5
<151>  2018-02-12

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of anti-CD40 antibody


<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  May be S or Q

<400>  1

Arg Ser Ser Gln Ser Leu Ala Ser Ser Xaa Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of anti-CD40 antibody

<400>  2

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of anti-CD40 antibody

<400>  3

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of anti-CD40 antibody


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  May be I or V

<400>  4

Gly Phe Ser Leu Ser Arg Tyr 
1               5           


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of anti-CD40 antibody

<400>  5

Trp Gly Gly Gly Ser Thr Asp 
1               5           


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of anti-CD40 antibody

<400>  6

Thr Asp Gly Asp Tyr 
1               5   


<210>  7
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD40 heavy chain variable region


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is Q

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is Q or V

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  is P or G

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  is S or G

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  is E, Q, or G

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  is T or S

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  is S or R

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  is I or L

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  is T or S

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  is T or A

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  is I, L, or V

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  is I, L, or V

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  is P or A

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  is P or L

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  is M or I

<220>
<221>  MISC_FEATURE
<222>  (60)..(61)
<223>  is ST or NP

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  is L or V

<220>
<221>  MISC_FEATURE
<222>  (65)..(65)
<223>  is S or G

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  is L or F

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  is T or N

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  is S or A

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  is S or T

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  is Q or S

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  is S or Y

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  is K or Q

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  is M or L

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  is S

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  is R or T

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  is A

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  is A or E

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  is V

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  is L

<400>  7

Gln Val Xaa Leu Xaa Glu Ser Gly Xaa Gly Leu Val Lys Pro Xaa Xaa 
1               5                   10                  15      


Xaa Leu Xaa Xaa Xaa Cys Xaa Val Ser Gly Phe Ser Xaa Ser Arg Tyr 
            20                  25                  30          


Ser Val Tyr Trp Xaa Arg Gln Xaa Pro Gly Lys Gly Xaa Glu Trp Xaa 
        35                  40                  45              


Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Xaa Xaa Ser Xaa Lys 
    50                  55                  60                  


Xaa Arg Xaa Thr Ile Ser Lys Asp Xaa Xaa Lys Xaa Xaa Val Xaa Leu 
65                  70                  75                  80  


Xaa Xaa Xaa Ser Leu Xaa Xaa Xaa Asp Thr Ala Xaa Tyr Tyr Cys Val 
                85                  90                  95      


Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Xaa Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  8
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti CD40 light chain variable region


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  is ELQL or DIVM

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  is L or P

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  is S or D

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  is S or Q

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  is R or K

<400>  8

Xaa Xaa Xaa Xaa Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Xaa Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Xaa Ser 
            20                  25                  30          


Xaa Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Xaa Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Optional sequence Z1, Z2, Z3 and Z4

<400>  9

Glu Leu Gln Leu 
1               


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Optional sequence Z1, Z2, Z3 and Z4

<400>  10

Asp Ile Val Met 
1               


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1A

<400>  11

Arg Ser Ser Gln Ser Leu Ala Ser Ser Ser Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1B

<400>  12

Arg Ser Ser Gln Ser Leu Ala Ser Ser Gln Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2

<400>  13

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3

<400>  14

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  15
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-FR1A

<400>  15

Glu Leu Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  16
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-FR1B

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-FR2A

<400>  17

Trp Tyr Leu Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-FR2B

<400>  18

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  19
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-FR3

<400>  19

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-FR4

<400>  20

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
1               5                   10      


<210>  21
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-1

<400>  21

Glu Leu Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Ser Ser 
            20                  25                  30          


Ser Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  22
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-2

<400>  22

Glu Leu Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Ser Ser 
            20                  25                  30          


Gln Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  23
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-4

<400>  23

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Ser Ser 
            20                  25                  30          


Gln Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1A

<400>  24

Gly Phe Ser Leu Ser Arg Tyr 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1B

<400>  25

Gly Phe Ser Ile Ser Arg Tyr 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1C

<400>  26

Gly Phe Ser Val Ser Arg Tyr 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2

<400>  27

Trp Gly Gly Gly Ser Thr Asp 
1               5           


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3

<400>  28

Thr Asp Gly Asp Tyr 
1               5   


<210>  29
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR1A

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser 
            20                  25  


<210>  30
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR1B

<400>  30

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  31
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR1C

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser 
            20                  25  


<210>  32
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR2A

<400>  32

Ser Val Tyr Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu Trp Met 
1               5                   10                  15      


Gly Met Met 
            


<210>  33
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR2B

<400>  33

Ser Val Tyr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
1               5                   10                  15      


Gly Met Met 
            


<210>  34
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR2C

<400>  34

Ser Val Tyr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly Met Met 
            


<210>  35
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR2D

<400>  35

Ser Val Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
1               5                   10                  15      


Gly Met Met 
            


<210>  36
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR3A

<400>  36

Tyr Ser Thr Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser 
1               5                   10                  15      


Lys Ser Gln Val Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Val Arg 
        35                  


<210>  37
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR3B

<400>  37

Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser 
1               5                   10                  15      


Lys Ser Gln Val Ser Leu Lys Leu Ser Ser Leu Thr Ala Ala Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Val Arg 
        35                  


<210>  38
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR3C

<400>  38

Tyr Ser Thr Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala 
1               5                   10                  15      


Lys Thr Ser Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Val Arg 
        35                  


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-FR4

<400>  39

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  40
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-1

<400>  40

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val Tyr Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Ser Thr Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  41
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_2

<400>  41

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val Tyr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Ser Thr Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  42
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-3

<400>  42

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val Tyr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  43
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-4

<400>  43

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Ser Thr Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Thr Ser Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tryptic peptide H10

<400>  44

Met Asn Ser Leu Arg 
1               5   


<210>  45
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tryptic peptide L2

<400>  45

Ser Ser Gln Ser Leu Ala Asn Ser Asn Gly Asn Thr Tyr Leu His Trp 
1               5                   10                  15      


Tyr Leu Gln Arg Pro Gly Gln Ser Pro Arg 
            20                  25      


<210>  46
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG102_VL

<400>  46

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Glu Leu Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Ala Asn Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  47
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG102_VL_1

<400>  47

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Glu Leu Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Ala Ser Ser Ser Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  48
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG102_VL_2

<400>  48

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Glu Leu Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Ala Ser Ser Gln Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  49
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG102_VL_3

<400>  49

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Glu Leu Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Ala Asp Ser Gln Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  50
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG102_VL_4

<400>  50

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Ala Ser Ser Gln Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  51
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG102_VL_5

<400>  51

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Ala Ala Ser Ala Gly Ala Thr Tyr Leu His Trp Tyr Leu Glu Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  52
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG102_VH

<400>  52

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Arg Tyr Ser Val Tyr Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro 
    50                  55                  60                  


Glu Trp Met Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Ser Thr 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln 
                85                  90                  95      


Val Ser Leu Lys Met Asn Ser Leu Arg Thr Asp Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
        355                 360                 365             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455             


<210>  53
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG102_VH_1

<400>  53

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Arg Tyr Ser Val Tyr Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro 
    50                  55                  60                  


Glu Trp Met Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Ser Thr 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln 
                85                  90                  95      


Val Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Val Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
        355                 360                 365             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455             


<210>  54
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG102_VH_2

<400>  54

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Arg Tyr Ser Val Tyr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Ser Thr 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln 
                85                  90                  95      


Val Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Val Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
        355                 360                 365             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455             


<210>  55
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG102_VH_3

<400>  55

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Arg Tyr Ser Val Tyr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln 
                85                  90                  95      


Val Ser Leu Lys Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Val Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
        355                 360                 365             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455             


<210>  56
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG102_VH_4

<400>  56

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Arg Tyr Ser Val Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Ser Thr 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Thr Ser 
                85                  90                  95      


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Val Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
        355                 360                 365             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455             


<210>  57
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PG102_VH_5

<400>  57

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Lys Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Arg Tyr Ser Val Tyr Trp Val Lys Glu Pro Pro Gly Lys Gly Pro 
    50                  55                  60                  


Glu Trp Met Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Ser Thr 
65                  70                  75                  80  


Ser Leu Lys Ser Lys Leu Thr Met Ser Lys Asp Thr Ser Lys Ser Gln 
                85                  90                  95      


Phe Ser Leu Lys Met Ser Ser Leu Thr Ala Ala Asn Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Leu 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
        355                 360                 365             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455             


<210>  58
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region variant PG102_VL

<400>  58

Glu Leu Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  59
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region variant PG102_VL1

<400>  59

Glu Leu Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Ser Ser 
            20                  25                  30          


Ser Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  60
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region variant PG102_VL2

<400>  60

Glu Leu Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Ser Ser 
            20                  25                  30          


Gln Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  61
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region variant PG102_VL3

<400>  61

Glu Leu Gln Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Asp Ser 
            20                  25                  30          


Gln Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  62
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region variant PG102_VL4

<400>  62

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Ser Ser 
            20                  25                  30          


Gln Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  63
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region variant PG102 VH

<400>  63

Gln Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val Tyr Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Ser Thr Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Arg Thr Asp Asp Thr Ala Met Tyr Tyr Cys Val 
                85                  90                  95      


Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  64
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region variant PG102_VH1

<400>  64

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val Tyr Trp Ile Arg Gln Pro Pro Gly Lys Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Ser Thr Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  65
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region variant PG102_VH2

<400>  65

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val Tyr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Ser Thr Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  66
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region variant PG102_VH3

<400>  66

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val Tyr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  67
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region variant PG102_VH4

<400>  67

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Arg Tyr 
            20                  25                  30          


Ser Val Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Met Trp Gly Gly Gly Ser Thr Asp Tyr Ser Thr Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Thr Ser Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Thr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


