                         SEQUENCE LISTING

<110>  University of Miami
 
<120>  INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX KINASE
        ("NACK") AND METHODS FOR USE OF THE SAME

<130>  32286/51617 PC

<150>  US 62/626,870
<151>  2018-02-06

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1406
<212>  PRT
<213>  Homo sapiens

<400>  1

Met His Gln Thr Leu Cys Leu Asn Pro Glu Ser Leu Lys Met Ser Ala 
1               5                   10                  15      


Cys Ser Asp Phe Val Glu His Ile Trp Lys Pro Gly Ser Cys Lys Asn 
            20                  25                  30          


Cys Phe Cys Leu Arg Ser Asp His Gln Leu Val Ala Gly Pro Pro Gln 
        35                  40                  45              


Pro Arg Ala Gly Ser Leu Pro Pro Pro Pro Arg Leu Pro Pro Arg Pro 
    50                  55                  60                  


Glu Asn Cys Arg Leu Glu Asp Glu Gly Val Asn Ser Ser Pro Tyr Ser 
65                  70                  75                  80  


Lys Pro Thr Ile Ala Val Lys Pro Thr Met Met Ser Ser Glu Ala Ser 
                85                  90                  95      


Asp Val Trp Thr Glu Ala Asn Leu Ser Ala Glu Val Ser Gln Val Ile 
            100                 105                 110         


Trp Arg Arg Ala Pro Gly Lys Leu Pro Leu Pro Lys Gln Glu Asp Ala 
        115                 120                 125             


Pro Val Val Tyr Leu Gly Ser Phe Arg Gly Val Gln Lys Pro Ala Gly 
    130                 135                 140                 


Pro Ser Thr Ser Pro Asp Gly Asn Ser Arg Cys Pro Pro Ala Tyr Thr 
145                 150                 155                 160 


Met Val Gly Leu His Asn Leu Glu Pro Arg Gly Glu Arg Asn Ile Ala 
                165                 170                 175     


Phe His Pro Val Ser Phe Pro Glu Glu Lys Ala Val His Lys Glu Lys 
            180                 185                 190         


Pro Ser Phe Pro Tyr Gln Asp Arg Pro Ser Thr Gln Glu Ser Phe Arg 
        195                 200                 205             


Gln Lys Leu Ala Ala Phe Ala Gly Thr Thr Ser Gly Cys His Gln Gly 
    210                 215                 220                 


Pro Gly Pro Leu Arg Glu Ser Leu Pro Ser Glu Asp Asp Ser Asp Gln 
225                 230                 235                 240 


Arg Cys Ser Pro Ser Gly Asp Ser Glu Gly Gly Glu Tyr Cys Ser Ile 
                245                 250                 255     


Leu Asp Cys Cys Pro Gly Ser Pro Val Ala Lys Ala Ala Ser Gln Thr 
            260                 265                 270         


Ala Gly Ser Arg Gly Arg His Gly Gly Arg Asp Cys Ser Pro Thr Cys 
        275                 280                 285             


Trp Glu Gln Gly Lys Cys Ser Gly Pro Ala Glu Gln Glu Lys Arg Gly 
    290                 295                 300                 


Pro Ser Phe Pro Lys Glu Cys Cys Ser Gln Gly Pro Thr Ala His Pro 
305                 310                 315                 320 


Ser Cys Leu Gly Pro Lys Lys Leu Ser Leu Thr Ser Glu Ala Ala Ile 
                325                 330                 335     


Ser Ser Asp Gly Leu Ser Cys Gly Ser Gly Ser Gly Ser Gly Ser Gly 
            340                 345                 350         


Ala Ser Ser Pro Phe Val Pro His Leu Glu Ser Asp Tyr Cys Ser Leu 
        355                 360                 365             


Met Lys Glu Pro Ala Pro Glu Lys Gln Gln Asp Pro Gly Cys Pro Gly 
    370                 375                 380                 


Val Thr Pro Ser Arg Cys Leu Gly Leu Thr Gly Glu Pro Gln Pro Pro 
385                 390                 395                 400 


Ala His Pro Arg Glu Ala Thr Gln Pro Glu Pro Ile Tyr Ala Glu Ser 
                405                 410                 415     


Thr Lys Arg Lys Lys Ala Ala Pro Val Pro Ser Lys Ser Gln Ala Lys 
            420                 425                 430         


Ile Glu His Ala Ala Ala Ala Gln Gly Gln Gly Gln Val Cys Thr Gly 
        435                 440                 445             


Asn Ala Trp Ala Gln Lys Ala Ala Ser Gly Trp Gly Arg Asp Ser Pro 
    450                 455                 460                 


Asp Pro Thr Pro Gln Val Ser Ala Thr Ile Thr Val Met Ala Ala His 
465                 470                 475                 480 


Pro Glu Glu Asp His Arg Thr Ile Tyr Leu Ser Ser Pro Asp Ser Ala 
                485                 490                 495     


Val Gly Val Gln Trp Pro Arg Gly Pro Val Ser Gln Asn Ser Glu Val 
            500                 505                 510         


Gly Glu Glu Glu Thr Ser Ala Gly Gln Gly Leu Ser Ser Arg Glu Ser 
        515                 520                 525             


His Ala His Ser Ala Ser Glu Ser Lys Pro Lys Glu Arg Pro Ala Ile 
    530                 535                 540                 


Pro Pro Lys Leu Ser Lys Ser Ser Pro Val Gly Ser Pro Val Ser Pro 
545                 550                 555                 560 


Ser Ala Gly Gly Pro Pro Val Ser Pro Leu Ala Asp Leu Ser Asp Gly 
                565                 570                 575     


Ser Ser Gly Gly Ser Ser Ile Gly Pro Gln Pro Pro Ser Gln Gly Pro 
            580                 585                 590         


Ala Asp Pro Ala Pro Ser Cys Arg Thr Asn Gly Val Ala Ile Ser Asp 
        595                 600                 605             


Pro Ser Arg Cys Pro Gln Pro Ala Ala Ser Ser Ala Ser Glu Gln Arg 
    610                 615                 620                 


Arg Pro Arg Phe Gln Ala Gly Thr Trp Ser Arg Gln Cys Arg Ile Glu 
625                 630                 635                 640 


Glu Glu Glu Glu Val Glu Gln Glu Leu Leu Ser His Ser Trp Gly Arg 
                645                 650                 655     


Glu Thr Lys Asn Gly Pro Thr Asp His Ser Asn Ser Thr Thr Trp His 
            660                 665                 670         


Arg Leu His Pro Thr Asp Gly Ser Ser Gly Gln Asn Ser Lys Val Gly 
        675                 680                 685             


Thr Gly Met Ser Lys Ser Ala Ser Phe Ala Phe Glu Phe Pro Lys Asp 
    690                 695                 700                 


Arg Ser Gly Ile Glu Thr Phe Ser Pro Pro Pro Pro Pro Pro Lys Ser 
705                 710                 715                 720 


Arg His Leu Leu Lys Met Asn Lys Ser Ser Ser Asp Leu Glu Lys Val 
                725                 730                 735     


Ser Gln Gly Ser Ala Glu Ser Leu Ser Pro Ser Phe Arg Gly Val His 
            740                 745                 750         


Val Ser Phe Thr Thr Gly Ser Thr Asp Ser Leu Ala Ser Asp Ser Arg 
        755                 760                 765             


Thr Cys Ser Asp Gly Gly Pro Ser Ser Glu Leu Ala His Ser Pro Thr 
    770                 775                 780                 


Asn Ser Gly Lys Lys Leu Phe Ala Pro Val Pro Phe Pro Ser Gly Ser 
785                 790                 795                 800 


Thr Glu Asp Val Ser Pro Ser Gly Pro Gln Gln Pro Pro Pro Leu Pro 
                805                 810                 815     


Gln Lys Lys Ile Val Ser Arg Ala Ala Ser Ser Pro Asp Gly Phe Phe 
            820                 825                 830         


Trp Thr Gln Gly Ser Pro Lys Pro Gly Thr Ala Ser Pro Lys Leu Asn 
        835                 840                 845             


Leu Ser His Ser Glu Thr Asn Val His Asp Glu Ser His Phe Ser Tyr 
    850                 855                 860                 


Ser Leu Ser Pro Gly Asn Arg His His Pro Val Phe Ser Ser Ser Asp 
865                 870                 875                 880 


Pro Leu Glu Lys Ala Phe Lys Gly Ser Gly His Trp Leu Pro Ala Ala 
                885                 890                 895     


Gly Leu Ala Gly Asn Arg Gly Gly Cys Gly Ser Pro Gly Leu Gln Cys 
            900                 905                 910         


Lys Gly Ala Pro Ser Ala Ser Ser Ser Gln Leu Ser Val Ser Ser Gln 
        915                 920                 925             


Ala Ser Thr Gly Ser Thr Gln Leu Gln Leu His Gly Leu Leu Ser Asn 
    930                 935                 940                 


Ile Ser Ser Lys Glu Gly Thr Tyr Ala Lys Leu Gly Gly Leu Tyr Thr 
945                 950                 955                 960 


Gln Ser Leu Ala Arg Leu Val Ala Lys Cys Glu Asp Leu Phe Met Gly 
                965                 970                 975     


Gly Gln Lys Lys Glu Leu His Phe Asn Glu Asn Asn Trp Ser Leu Phe 
            980                 985                 990         


Lys Leu Thr Cys Asn Lys Pro Cys  Cys Asp Ser Gly Asp  Ala Ile Tyr 
        995                 1000                 1005             


Tyr Cys  Ala Thr Cys Ser Glu  Asp Pro Gly Ser Thr  Tyr Ala Val 
    1010                 1015                 1020             


Lys Ile  Cys Lys Ala Pro Glu  Pro Lys Thr Val Ser  Tyr Cys Ser 
    1025                 1030                 1035             


Pro Ser  Val Pro Val His Phe  Asn Ile Gln Gln Asp  Cys Gly His 
    1040                 1045                 1050             


Phe Val  Ala Ser Val Pro Ser  Ser Met Leu Ser Ser  Pro Asp Ala 
    1055                 1060                 1065             


Pro Lys  Asp Pro Val Pro Ala  Leu Pro Thr His Pro  Pro Ala Gln 
    1070                 1075                 1080             


Glu Gln  Asp Cys Val Val Val  Ile Thr Arg Glu Val  Pro His Gln 
    1085                 1090                 1095             


Thr Ala  Ser Asp Phe Val Arg  Asp Ser Ala Ala Ser  His Gln Ala 
    1100                 1105                 1110             


Glu Pro  Glu Ala Tyr Glu Arg  Arg Val Cys Phe Leu  Leu Leu Gln 
    1115                 1120                 1125             


Leu Cys  Asn Gly Leu Glu His  Leu Lys Glu His Gly  Ile Ile His 
    1130                 1135                 1140             


Arg Asp  Leu Cys Leu Glu Asn  Leu Leu Leu Val His  Cys Thr Leu 
    1145                 1150                 1155             


Gln Ala  Gly Pro Gly Pro Ala  Pro Ala Pro Ala Pro  Ala Pro Ala 
    1160                 1165                 1170             


Pro Ala  Ala Ala Ala Pro Pro  Cys Ser Ser Ala Ala  Pro Pro Ala 
    1175                 1180                 1185             


Gly Gly  Thr Leu Ser Pro Ala  Ala Gly Pro Ala Ser  Pro Glu Gly 
    1190                 1195                 1200             


Pro Arg  Glu Lys Gln Leu Pro  Arg Leu Ile Ile Ser  Asn Phe Leu 
    1205                 1210                 1215             


Lys Ala  Lys Gln Lys Pro Gly  Gly Thr Pro Asn Leu  Gln Gln Lys 
    1220                 1225                 1230             


Lys Ser  Gln Ala Arg Leu Ala  Pro Glu Ile Val Ser  Ala Ser Gln 
    1235                 1240                 1245             


Tyr Arg  Lys Phe Asp Glu Phe  Gln Thr Gly Ile Leu  Ile Tyr Glu 
    1250                 1255                 1260             


Leu Leu  His Gln Pro Asn Pro  Phe Glu Val Arg Ala  Gln Leu Arg 
    1265                 1270                 1275             


Glu Arg  Asp Tyr Arg Gln Glu  Asp Leu Pro Pro Leu  Pro Ala Leu 
    1280                 1285                 1290             


Ser Leu  Tyr Ser Pro Gly Leu  Gln Gln Leu Ala His  Leu Leu Leu 
    1295                 1300                 1305             


Glu Ala  Asp Pro Ile Lys Arg  Ile Arg Ile Gly Glu  Ala Lys Arg 
    1310                 1315                 1320             


Val Leu  Gln Cys Leu Leu Trp  Gly Pro Arg Arg Glu  Leu Val Gln 
    1325                 1330                 1335             


Gln Pro  Gly Thr Ser Glu Glu  Ala Leu Cys Gly Thr  Leu His Asn 
    1340                 1345                 1350             


Trp Ile  Asp Met Lys Arg Ala  Leu Met Met Met Lys  Phe Ala Glu 
    1355                 1360                 1365             


Lys Ala  Val Asp Arg Arg Arg  Gly Val Glu Leu Glu  Asp Trp Leu 
    1370                 1375                 1380             


Cys Cys  Gln Tyr Leu Ala Ser  Ala Glu Pro Gly Ala  Leu Leu Gln 
    1385                 1390                 1395             


Ser Leu  Lys Leu Leu Gln Leu  Leu 
    1400                 1405     


<210>  2
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  2
cgtgtctcct cctcccatt                                                    19


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  3

Gly Gly Gly Gly Gly Ala Thr Thr Cys Cys Gly Cys Thr Gly Thr Thr 
1               5                   10                  15      


Ala Thr 
        


