                         SEQUENCE LISTING

<110>  BERKELEY LIGHTS, INC.
       THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120>  MUTANT IDH1 SPECIFIC T CELL RECEPTOR

<130>  01149-0003-PCT

<150>  US 62/628,992
<151>  2018-02-10

<150>  US 62/628,986
<151>  2018-02-10

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A1 alpha nucleotide sequence (TRAV26)

<400>  1
atgaggctgg tggcaagagt aactgtgttt ctgacctttg gaactataat tgatgctaag       60

accacccagc ccacctccat ggattgcgct gaaggaagag ctgcaaacct gccttgtaat      120

cactctacca tcagtggaaa tgagtatgtg tattggtatc gacagattca ctcccagggg      180

ccacagtata tcattcatgg tctaaaaaac aatgaaacca atgaaatggc ctctctgatc      240

atcacagaag acagaaagtc cagcaccttg atcctgcccc acgctacgct gagagacact      300

gctgtgtact attgcatcgt cagagtctgg aatgacatgc gctttggagc agggaccaga      360

ctgacagtaa aaccaaatat ccagaaccct gaccctgccg tgtaccagct gagagactct      420

aaatccagtg acaagtctgt ctgcctattc accgattttg attctcaaac aaatgtgtca      480

caaagtaagg attctgatgt gtatatcaca gacaaaactg tgctagacat gaggtctatg      540

gacttcaaga gcaacagtgc tgtggcctgg agcaacaaat ctgactttgc atgtgcaaac      600

gccttcaaca acagcattat tccagaagac accttcttcc ccagcccaga aagttcctgt      660

gatgtcaagc tggtcgagaa aagctttgaa acagatacga acctaaactt tcaaaacctg      720

tcagtgattg ggttccgaat cctcctcctg aaagtggccg ggtttaatct gctcatgacg      780

ctgcggctgt ggtccagc                                                    798


<210>  2
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A1 alpha amino acid sequence (TRAV26)

<400>  2

Met Arg Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Thr Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Val Trp Asn Asp 
            100                 105                 110         


Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Asn Ile Gln 
        115                 120                 125             


Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp 
    130                 135                 140                 


Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser 
145                 150                 155                 160 


Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp 
                165                 170                 175     


Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn 
            180                 185                 190         


Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro 
        195                 200                 205             


Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu 
    210                 215                 220                 


Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu 
225                 230                 235                 240 


Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
                245                 250                 255     


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265     


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A1 alpha CDR1 nucleotide sequence

<400>  3
accatcagtg gaaatgagta t                                                 21


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A1 alpha CDR1 amino acid sequence

<400>  4

Thr Ile Ser Gly Asn Glu Tyr 
1               5           


<210>  5
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A1 alpha CDR2 nucleotide sequence

<400>  5
ggtctaaaaa acaat                                                        15


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A1 alpha CDR2 amino acid sequence

<400>  6

Gly Leu Lys Asn Asn 
1               5   


<210>  7
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A1 alpha CDR3 nucleotide sequence

<400>  7
atcgtcagag tctggaatga catgcgc                                           27


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A1 alpha CDR3 amino acid sequence

<400>  8

Ile Val Arg Val Trp Asn Asp Met Arg 
1               5                   


<210>  9
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A1 beta nucleotide sequence (TRBV9)

<400>  9
atgggcttca ggctcctctg ctgtgtggcc ttttgtctcc tgggagcagg cccagtggat       60

tctggagtca cacaaacccc aaagcacctg atcacagcaa ctggacagcg agtgacgctg      120

agatgctccc ctaggtctag agacctctct gtgtactggt accaacagag cctggaccag      180

ggcctccagt tcctcattca gtattataat ggagaagaga gagcaaaagg aaacattctt      240

gaacgattct ccgcacaaca gttccctgac ttgcactctg aactaaacct gagctctctg      300

gagctggggg actcagcttt gtatttctgt gccagcagcg tagaacccgg gacatcagcc      360

tacgagcagt acttcgggcc gggcaccagg ctcacggtca cagaggacct gaaaaacgtg      420

ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag      480

gccacactgg tgtgcctggc cacaggcttc taccccgacc acgtggagct gagctggtgg      540

gtgaatggga aggaggtgca cagtggggtc agcacagacc cgcagcccct caaggagcag      600

cccgccctca atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc      660

tggcagaacc cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat      720

gacgagtgga cccaggatag ggccaaacct gtcacccaga tcgtcagcgc cgaggcctgg      780

ggtagagcag actgtggctt cacctccgag tcttaccagc aaggggtcct gtctgccacc      840

atcctctatg agatcttgct agggaaggcc accttgtatg ccgtgctggt cagtgccctc      900

gtgctgatgg ccatggtcaa gagaaaggat tccagaggc                             939


<210>  10
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A1 beta amino acid sequence (TRBV9)

<400>  10

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Val Glu Pro Gly Thr Ser Ala Tyr Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310             


<210>  11
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A1 beta CDR1 nucleotide sequence

<400>  11
tctagagacc tctct                                                        15


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A1 beta CDR1 amino acid sequence

<400>  12

Ser Arg Asp Leu Ser 
1               5   


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A1 beta CDR2 nucleotide sequence

<400>  13
tattataatg gagaagag                                                     18


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A1 beta CDR2 amino acid sequence

<400>  14

Tyr Tyr Asn Gly Glu Glu 
1               5       


<210>  15
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A1 beta CDR3 nucleotide sequence

<400>  15
gccagcagcg tagaacccgg gacatcagcc tacgagcagt ac                          42


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A1 beta CDR3 amino acid sequence

<400>  16

Ala Ser Ser Val Glu Pro Gly Thr Ser Ala Tyr Glu Gln Tyr 
1               5                   10                  


<210>  17
<211>  813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A3 alpha nucleotide sequence (TRAV5)

<400>  17
atgaagacat ttgctggatt ttcgttcctg tttttgtggc tgcagctgga ctgtatgagt       60

agaggagagg atgtggagca gagtcttttc ctgagtgtcc gagagggaga cagctccgtt      120

ataaactgca cttacacaga cagctcctcc acctacttat actggtataa gcaagaacct      180

ggagcaggtc tccagttgct gacgtatatt ttttcaaata tggacatgaa acaagaccaa      240

agactcactg ttctattgaa taaaaaggat aaacatctgt ctctgcgcat tgcagacacc      300

cagactgggg actcagctat ctacttctgt gcagagaggg gtaacaatga catgcgcttt      360

ggagcaggga ccagactgac agtaaaacca aatatccaga accctgaccc tgccgtgtac      420

cagctgagag actctaaatc cagtgacaag tctgtctgcc tattcaccga ttttgattct      480

caaacaaatg tgtcacaaag taaggattct gatgtgtata tcacagacaa aactgtgcta      540

gacatgaggt ctatggactt caagagcaac agtgctgtgg cctggagcaa caaatctgac      600

tttgcatgtg caaacgcctt caacaacagc attattccag aagacacctt cttccccagc      660

ccagaaagtt cctgtgatgt caagctggtc gagaaaagct ttgaaacaga tacgaaccta      720

aactttcaaa acctgtcagt gattgggttc cgaatcctcc tcctgaaagt ggccgggttt      780

aatctgctca tgacgctgcg gctgtggtcc agc                                   813


<210>  18
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A3 alpha amino acid sequence (TRAV5)

<400>  18

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Arg Gly Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
    130                 135                 140                 


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
                165                 170                 175     


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
            180                 185                 190         


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
        195                 200                 205             


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
    210                 215                 220                 


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  19
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A3 alpha CDR1 nucleotide sequence

<400>  19
gacagctcct ccacctac                                                     18


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A3 alpha CDR1 amino acid sequence

<400>  20

Asp Ser Ser Ser Thr Tyr 
1               5       


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A3 alpha CDR2 nucleotide sequence

<400>  21
attttttcaa atatggacat g                                                 21


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A3 alpha CDR2 amino acid sequence

<400>  22

Ile Phe Ser Asn Met Asp Met 
1               5           


<210>  23
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A3 alpha CDR3 nucleotide sequence

<400>  23
gcagagaggg gtaacaatga catgcgc                                           27


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A3 alpha CDR3 amino acid sequence

<400>  24

Ala Glu Arg Gly Asn Asn Asp Met Arg 
1               5                   


<210>  25
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A3 beta nucleotide sequence (TRBV20)

<400>  25
atgctgctgc ttctgctgct tctggggcca ggctccgggc ttggtgctgt cgtctctcaa       60

catccgagct gggttatctg taagagtgga acctctgtga agatcgagtg ccgttccctg      120

gactttcagg ccacaactat gttttggtat cgtcagttcc cgaaacagag tctcatgctg      180

atggcaactt ccaatgaggg ctccaaggcc acatacgagc aaggcgtcga gaaggacaag      240

tttctcatca accatgcaag cctgaccttg tccactctga cagtgaccag tgcccatcct      300

gaagacagca gcttctacat ctgcagtgct agagtgggtt tcacccctac ctacgagcag      360

tacttcgggc cgggcaccag gctcacggtc acagaggacc tgaaaaacgt gttcccaccc      420

gaggtcgctg tgtttgagcc atcagaagca gagatctccc acacccaaaa ggccacactg      480

gtgtgcctgg ccacaggctt ctaccccgac cacgtggagc tgagctggtg ggtgaatggg      540

aaggaggtgc acagtggggt cagcacagac ccgcagcccc tcaaggagca gcccgccctc      600

aatgactcca gatactgcct gagcagccgc ctgagggtct cggccacctt ctggcagaac      660

ccccgcaacc acttccgctg tcaagtccag ttctacgggc tctcggagaa tgacgagtgg      720

acccaggata gggccaaacc tgtcacccag atcgtcagcg ccgaggcctg gggtagagca      780

gactgtggct tcacctccga gtcttaccag caaggggtcc tgtctgccac catcctctat      840

gagatcttgc tagggaaggc caccttgtat gccgtgctgg tcagtgccct cgtgctgatg      900

gccatggtca agagaaagga ttccagaggc                                       930


<210>  26
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A3 beta amino acid sequence (TRBV20)

<400>  26

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ser Gly Leu Gly Ala 
1               5                   10                  15      


Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser 
            20                  25                  30          


Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser 
    50                  55                  60                  


Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys 
65                  70                  75                  80  


Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr 
                85                  90                  95      


Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg Val 
            100                 105                 110         


Gly Phe Thr Pro Thr Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  27
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A3 beta CDR1 nucleotide sequence

<400>  27
gactttcagg ccacaact                                                     18


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A3 beta CDR1 amino acid sequence

<400>  28

Asp Phe Gln Ala Thr Thr 
1               5       


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A3 beta CDR2 nucleotide sequence

<400>  29
tccaatgagg gctccaaggc c                                                 21


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A3 beta CDR2 amino acid sequence

<400>  30

Ser Asn Glu Gly Ser Lys Ala 
1               5           


<210>  31
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A3 beta CDR3 nucleotide sequence

<400>  31
agtgctagag tgggtttcac ccctacctac gagcagtac                              39


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A3 beta CDR3 amino acid sequence

<400>  32

Ser Ala Arg Val Gly Phe Thr Pro Thr Tyr Glu Gln Tyr 
1               5                   10              


<210>  33
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1 alpha nucleotide sequence (TRAV16)

<400>  33
atgaagccca ccctcatctc agtgcttgtg ataatattta tactcagagg aacaagagcc       60

cagagagtga ctcagcccga gaagctcctc tctgtcttta aaggggcccc agtggagctg      120

aagtgcaact attcctattc tgggagtcct gaactcttct ggtatgtcca gtactccaga      180

caacgcctcc agttactctt gagacacatc tctagagaga gcatcaaagg cttcactgct      240

aaccttaaca aaggcgagac atctttccac ctgaagaaac catttgctca agaggaagac      300

tcagccatgt attactgtgc tctaagtaat ggctttcaga aacttgtatt tggaactggc      360

acccgacttc tggtcagtcc aaatatccag aaccctgacc ctgccgtgta ccagctgaga      420

gactctaaat ccagtgacaa gtctgtctgc ctattcaccg attttgattc tcaaacaaat      480

gtgtcacaaa gtaaggattc tgatgtgtat atcacagaca aaactgtgct agacatgagg      540

tctatggact tcaagagcaa cagtgctgtg gcctggagca acaaatctga ctttgcatgt      600

gcaaacgcct tcaacaacag cattattcca gaagacacct tcttccccag cccagaaagt      660

tcctgtgatg tcaagctggt cgagaaaagc tttgaaacag atacgaacct aaactttcaa      720

aacctgtcag tgattgggtt ccgaatcctc ctcctgaaag tggccgggtt taatctgctc      780

atgacgctgc ggctgtggtc cagc                                             804


<210>  34
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1 alpha amino acid sequence (TRAV16)

<400>  34

Met Lys Pro Thr Leu Ile Ser Val Leu Val Ile Ile Phe Ile Leu Arg 
1               5                   10                  15      


Gly Thr Arg Ala Gln Arg Val Thr Gln Pro Glu Lys Leu Leu Ser Val 
            20                  25                  30          


Phe Lys Gly Ala Pro Val Glu Leu Lys Cys Asn Tyr Ser Tyr Ser Gly 
        35                  40                  45              


Ser Pro Glu Leu Phe Trp Tyr Val Gln Tyr Ser Arg Gln Arg Leu Gln 
    50                  55                  60                  


Leu Leu Leu Arg His Ile Ser Arg Glu Ser Ile Lys Gly Phe Thr Ala 
65                  70                  75                  80  


Asn Leu Asn Lys Gly Glu Thr Ser Phe His Leu Lys Lys Pro Phe Ala 
                85                  90                  95      


Gln Glu Glu Asp Ser Ala Met Tyr Tyr Cys Ala Leu Ser Asn Gly Phe 
            100                 105                 110         


Gln Lys Leu Val Phe Gly Thr Gly Thr Arg Leu Leu Val Ser Pro Asn 
        115                 120                 125             


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
    130                 135                 140                 


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
145                 150                 155                 160 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
                165                 170                 175     


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
            180                 185                 190         


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
        195                 200                 205             


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
    210                 215                 220                 


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  35
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1 alpha CDR1 nucleotide sequence

<400>  35
tattctggga gtcctgaa                                                     18


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1 alpha CDR1 amino acid sequence

<400>  36

Tyr Ser Gly Ser Pro Glu 
1               5       


<210>  37
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1 alpha CDR2 nucleotide sequence

<400>  37
cacatctcta ga                                                           12


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1 alpha CDR2 amino acid sequence

<400>  38

His Ile Ser Arg 
1               


<210>  39
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1 alpha CDR3 nucleotide sequence

<400>  39
gctctaagta atggctttca gaaacttgta                                        30


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1 alpha CDR3 amino acid sequence

<400>  40

Ala Leu Ser Asn Gly Phe Gln Lys Leu Val 
1               5                   10  


<210>  41
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Trp Val Lys Pro Ile Ile Ile Gly His His Ala Tyr Gly Asp Gln 
1               5                   10                  15      


Tyr Arg Ala Thr 
            20  


<210>  42
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Lys Lys Ile Ser Gly Gly Ser Val Val Glu Met Gln Gly Asp 
1               5                   10                  15      


Glu Met Thr Arg Ile Ile Trp Glu Leu Ile Lys Glu Lys Leu Ile Phe 
            20                  25                  30          


Pro Tyr Val Glu Leu Asp Leu His Ser Tyr Asp Leu Gly Ile Glu Asn 
        35                  40                  45              


Arg Asp Ala Thr Asn Asp Gln Val Thr Lys Asp Ala Ala Glu Ala Ile 
    50                  55                  60                  


Lys Lys His Asn Val Gly Val Lys Cys Ala Thr Ile Thr Pro Asp Glu 
65                  70                  75                  80  


Lys Arg Val Glu Glu Phe Lys Leu Lys Gln Met Trp Lys Ser Pro Asn 
                85                  90                  95      


Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Ala Ile 
            100                 105                 110         


Ile Cys Lys Asn Ile Pro Arg Leu Val Ser Gly Trp Val Lys Pro Ile 
        115                 120                 125             


Ile Ile Gly Arg His Ala Tyr Gly Asp Gln Tyr Arg Ala Thr Asp Phe 
    130                 135                 140                 


Val Val Pro Gly Pro Gly Lys Val Glu Ile Thr Tyr Thr Pro Ser Asp 
145                 150                 155                 160 


Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe Glu Glu Gly Gly 
                165                 170                 175     


Gly Val Ala Met Gly Met Tyr Asn Gln Asp Lys Ser Ile Glu Asp Phe 
            180                 185                 190         


Ala His Ser Ser Phe Gln Met Ala Leu Ser Lys Gly Trp Pro Leu Tyr 
        195                 200                 205             


Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe Lys 
    210                 215                 220                 


Asp Ile Phe Gln Glu Ile Tyr Asp Lys Gln Tyr Lys Ser Gln Phe Glu 
225                 230                 235                 240 


Ala Gln Lys Ile Trp Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala 
                245                 250                 255     


Gln Ala Met Lys Ser Glu Gly Gly Phe Ile Trp Ala Cys Lys Asn Tyr 
            260                 265                 270         


Asp Gly Asp Val Gln Ser Asp Ser Val Ala Gln Gly Tyr Gly Ser Leu 
        275                 280                 285             


Gly Met Met Thr Ser Val Leu Val Cys Pro Asp Gly Lys Thr Val Glu 
    290                 295                 300                 


Ala Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Met Tyr Gln 
305                 310                 315                 320 


Lys Gly Gln Glu Thr Ser Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp 
                325                 330                 335     


Thr Arg Gly Leu Ala His Arg Ala Lys Leu Asp Asn Asn Lys Glu Leu 
            340                 345                 350         


Ala Phe Phe Ala Asn Ala Leu Glu Glu Val Ser Ile Glu Thr Ile Glu 
        355                 360                 365             


Ala Gly Phe Met Thr Lys Asp Leu Ala Ala Cys Ile Lys Gly Leu Pro 
    370                 375                 380                 


Asn Val Gln Arg Ser Asp Tyr Leu Asn Thr Phe Glu Phe Met Asp Lys 
385                 390                 395                 400 


Leu Gly Glu Asn Leu Lys Ile Lys Leu Ala Gln Ala Lys Leu 
                405                 410                 


