               SEQUENCE LISTING

<110> University of Malta

<120> Treatment, Detection and Classification of Cancer

<130> MALBD/P68420PC

<140> PCT/EP2019/053733
<141> 2019-02-14

<150> GB 1802404.2
<151> 2018-02-14

<160> 20

<170> BiSSAP 1.3.6

<210> 1
<211> 1255
<212> PRT
<213> Homo sapiens


<220> 
<223> ERBB2 - polypeptide

<400> 1
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     
Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         
Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             
Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 
Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 
Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     
Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         
Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             
Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 
Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 
Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     
Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         
Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             
Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 
Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 
Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     
Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         
Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             
Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 
Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 
Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     
Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         
Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             
Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 
Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 
Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     
Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         
Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             
Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 
Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 
Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     
Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         
Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             
Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 
Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 
Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     
Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         
Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             
Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 
Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 
Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     
Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         
Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu 
        995                 1000                1005            
Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu 
    1010                1015                1020                
Val Pro Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly 
1025                1030                1035                1040
Gly Met Val His His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly 
                1045                1050                1055    
Gly Asp Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg 
            1060                1065                1070        
Ser Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly 
        1075                1080                1085            
Asp Leu Gly Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His 
    1090                1095                1100                
Asp Pro Ser Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu 
1105                1110                1115                1120
Pro Ser Glu Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln 
                1125                1130                1135    
Pro Glu Tyr Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro 
            1140                1145                1150        
Arg Glu Gly Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu 
        1155                1160                1165            
Arg Pro Lys Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val 
    1170                1175                1180                
Phe Ala Phe Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln 
1185                1190                1195                1200
Gly Gly Ala Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala 
                1205                1210                1215    
Phe Asp Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala 
            1220                1225                1230        
Pro Pro Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr 
        1235                1240                1245            
Leu Gly Leu Asp Val Pro Val 
    1250                1255

<210> 2
<211> 3768
<212> DNA
<213> Homo sapiens


<220> 
<223> ERBB2 - polynucleotide

<400> 2
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct ccaagtgttt     1200

gagactctgg aagagatcac aggttaccta tacatctcag catggccgga cagcctgcct     1260

gacctcagcg tcttccagaa cctgcaagta atccggggac gaattctgca caatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc actgagggaa     1380

ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt gcacacggtg     1440

ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc caaccggcca     1500

gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg agggcactgc     1560

tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc caggcactgt     1680

ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag     1740

gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc     1800

cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag     1860

ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct ggatgacaag     1920

ggctgccccg ccgagcagag agccagccct ctgacgtcca tcatctctgc ggtggttggc     1980

attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatcaagcg acggcagcag     2040

aagatccgga agtacacgat gcggagactg ctgcaggaaa cggagctggt ggagccgctg     2100

acacctagcg gagcgatgcc caaccaggcg cagatgcgga tcctgaaaga gacggagctg     2160

aggaaggtga aggtgcttgg atctggcgct tttggcacag tctacaaggg catctggatc     2220

cctgatgggg agaatgtgaa aattccagtg gccatcaaag tgttgaggga aaacacatcc     2280

cccaaagcca acaaagaaat cttagacgaa gcatacgtga tggctggtgt gggctcccca     2340

tatgtctccc gccttctggg catctgcctg acatccacgg tgcagctggt gacacagctt     2400

atgccctatg gctgcctctt agaccatgtc cgggaaaacc gcggacgcct gggctcccag     2460

gacctgctga actggtgtat gcagattgcc aaggggatga gctacctgga ggatgtgcgg     2520

ctcgtacaca gggacttggc cgctcggaac gtgctggtca agagtcccaa ccatgtcaaa     2580

attacagact tcgggctggc tcggctgctg gacattgacg agacagagta ccatgcagat     2640

gggggcaagg tgcccatcaa gtggatggcg ctggagtcca ttctccgccg gcggttcacc     2700

caccagagtg atgtgtggag ttatggtgtg actgtgtggg agctgatgac ttttggggcc     2760

aaaccttacg atgggatccc agcccgggag atccctgacc tgctggaaaa gggggagcgg     2820

ctgccccagc cccccatctg caccattgat gtctacatga tcatggtcaa atgttggatg     2880

attgactctg aatgtcggcc aagattccgg gagttggtgt ctgaattctc ccgcatggcc     2940

agggaccccc agcgctttgt ggtcatccag aatgaggact tgggcccagc cagtcccttg     3000

gacagcacct tctaccgctc actgctggag gacgatgaca tgggggacct ggtggatgct     3060

gaggagtatc tggtacccca gcagggcttc ttctgtccag accctgcccc gggcgctggg     3120

ggcatggtcc accacaggca ccgcagctca tctaccagga gtggcggtgg ggacctgaca     3180

ctagggctgg agccctctga agaggaggcc cccaggtctc cactggcacc ctccgaaggg     3240

gctggctccg atgtatttga tggtgacctg ggaatggggg cagccaaggg gctgcaaagc     3300

ctccccacac atgaccccag ccctctacag cggtacagtg aggaccccac agtacccctg     3360

ccctctgaga ctgatggcta cgttgccccc ctgacctgca gcccccagcc tgaatatgtg     3420

aaccagccag atgttcggcc ccagccccct tcgccccgag agggccctct gcctgctgcc     3480

cgacctgctg gtgccactct ggaaaggccc aagactctct ccccagggaa gaatggggtc     3540

gtcaaagacg tttttgcctt tgggggtgcc gtggagaacc ccgagtactt gacaccccag     3600

ggaggagctg cccctcagcc ccaccctcct cctgccttca gcccagcctt cgacaacctc     3660

tattactggg accaggaccc accagagcgg ggggctccac ccagcacctt caaagggaca     3720

cctacggcag agaacccaga gtacctgggt ctggacgtgc cagtgtga                  3768


<210> 3
<211> 595
<212> PRT
<213> Homo sapiens


<220> 
<223> ESR1 - polypeptide

<400> 3
Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      
Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          
Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              
Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  
Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  
Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      
Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         
Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             
Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 
Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 
Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     
Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         
Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             
Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 
Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 
Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     
Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         
Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     
Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu 
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         
Ala Thr Val 
        595 

<210> 4
<211> 1788
<212> DNA
<213> Homo sapiens


<220> 
<223> ESR1 - polynucleotide

<400> 4
atgaccatga ccctccacac caaagcatct gggatggccc tactgcatca gatccaaggg      60

aacgagctgg agcccctgaa ccgtccgcag ctcaagatcc ccctggagcg gcccctgggc     120

gaggtgtacc tggacagcag caagcccgcc gtgtacaact accccgaggg cgccgcctac     180

gagttcaacg ccgcggccgc cgccaacgcg caggtctacg gtcagaccgg cctcccctac     240

ggccccgggt ctgaggctgc ggcgttcggc tccaacggcc tggggggttt ccccccactc     300

aacagcgtgt ctccgagccc gctgatgcta ctgcacccgc cgccgcagct gtcgcctttc     360

ctgcagcccc acggccagca ggtgccctac tacctggaga acgagcccag cggctacacg     420

gtgcgcgagg ccggcccgcc ggcattctac aggccaaatt cagataatcg acgccagggt     480

ggcagagaaa gattggccag taccaatgac aagggaagta tggctatgga atctgccaag     540

gagactcgct actgtgcagt gtgcaatgac tatgcttcag gctaccatta tggagtctgg     600

tcctgtgagg gctgcaaggc cttcttcaag agaagtattc aaggacataa cgactatatg     660

tgtccagcca ccaaccagtg caccattgat aaaaacagga ggaagagctg ccaggcctgc     720

cggctccgta aatgctacga agtgggaatg atgaaaggtg ggatacgaaa agaccgaaga     780

ggagggagaa tgttgaaaca caagcgccag agagatgatg gggagggcag gggtgaagtg     840

gggtctgctg gagacatgag agctgccaac ctttggccaa gcccgctcat gatcaaacgc     900

tctaagaaga acagcctggc cttgtccctg acggccgacc agatggtcag tgccttgttg     960

gatgctgagc ccccgatact ctattccgag tatgatccta ccagaccctt cagtgaagct    1020

tcgatgatgg gcttactgac caacctggca gacagggagc tggttcacat gatcaactgg    1080

gcgaagaggg tgccaggctt tgtggatttg accctccatg atcaggtcca ccttctagaa    1140

tgtgcctggc tagagatcct gatgattggt ctcgtctggc gctccatgga gcacccaggg    1200

aagctactgt ttgctcctaa cttgctcttg gacaggaacc agggaaaatg tgtagagggc    1260

atggtggaga tcttcgacat gctgctggct acatcatctc ggttccgcat gatgaatctg    1320

cagggagagg agtttgtgtg cctcaaatct attattttgc ttaattctgg agtgtacaca    1380

tttctgtcca gcaccctgaa gtctctggaa gagaaggacc atatccaccg agtcctggac    1440

aagatcacag acactttgat ccacctgatg gccaaggcag gcctgaccct gcagcagcag    1500

caccagcggc tggcccagct cctcctcatc ctctcccaca tcaggcacat gagtaacaaa    1560

ggcatggagc atctgtacag catgaagtgc aagaacgtgg tgcccctcta tgacctgctg    1620

ctggagatgc tggacgccca ccgcctacat gcgcccacta gccgtggagg ggcatccgtg    1680

gaggagacgg accaaagcca cttggccact gcgggctcta cttcatcgca ttccttgcaa    1740

aagtattaca tcacggggga ggcagagggt ttccctgcca cggtctga                 1788


<210> 5
<211> 553
<212> PRT
<213> Homo sapiens


<220> 
<223> FOXC1 - polypeptide

<400> 5
Met Gln Ala Arg Tyr Ser Val Ser Ser Pro Asn Ser Leu Gly Val Val 
1               5                   10                  15      
Pro Tyr Leu Gly Gly Glu Gln Ser Tyr Tyr Arg Ala Ala Ala Ala Ala 
            20                  25                  30          
Ala Gly Gly Gly Tyr Thr Ala Met Pro Ala Pro Met Ser Val Tyr Ser 
        35                  40                  45              
His Pro Ala His Ala Glu Gln Tyr Pro Gly Gly Met Ala Arg Ala Tyr 
    50                  55                  60                  
Gly Pro Tyr Thr Pro Gln Pro Gln Pro Lys Asp Met Val Lys Pro Pro 
65                  70                  75                  80  
Tyr Ser Tyr Ile Ala Leu Ile Thr Met Ala Ile Gln Asn Ala Pro Asp 
                85                  90                  95      
Lys Lys Ile Thr Leu Asn Gly Ile Tyr Gln Phe Ile Met Asp Arg Phe 
            100                 105                 110         
Pro Phe Tyr Arg Asp Asn Lys Gln Gly Trp Gln Asn Ser Ile Arg His 
        115                 120                 125             
Asn Leu Ser Leu Asn Glu Cys Phe Val Lys Val Pro Arg Asp Asp Lys 
    130                 135                 140                 
Lys Pro Gly Lys Gly Ser Tyr Trp Thr Leu Asp Pro Asp Ser Tyr Asn 
145                 150                 155                 160 
Met Phe Glu Asn Gly Ser Phe Leu Arg Arg Arg Arg Arg Phe Lys Lys 
                165                 170                 175     
Lys Asp Ala Val Lys Asp Lys Glu Glu Lys Asp Arg Leu His Leu Lys 
            180                 185                 190         
Glu Pro Pro Pro Pro Gly Arg Gln Pro Pro Pro Ala Pro Pro Glu Gln 
        195                 200                 205             
Ala Asp Gly Asn Ala Pro Gly Pro Gln Pro Pro Pro Val Arg Ile Gln 
    210                 215                 220                 
Asp Ile Lys Thr Glu Asn Gly Thr Cys Pro Ser Pro Pro Gln Pro Leu 
225                 230                 235                 240 
Ser Pro Ala Ala Ala Leu Gly Ser Gly Ser Ala Ala Ala Val Pro Lys 
                245                 250                 255     
Ile Glu Ser Pro Asp Ser Ser Ser Ser Ser Leu Ser Ser Gly Ser Ser 
            260                 265                 270         
Pro Pro Gly Ser Leu Pro Ser Ala Arg Pro Leu Ser Leu Asp Gly Ala 
        275                 280                 285             
Asp Ser Ala Pro Pro Pro Pro Ala Pro Ser Ala Pro Pro Pro His His 
    290                 295                 300                 
Ser Gln Gly Phe Ser Val Asp Asn Ile Met Thr Ser Leu Arg Gly Ser 
305                 310                 315                 320 
Pro Gln Ser Ala Ala Ala Glu Leu Ser Ser Gly Leu Leu Ala Ser Ala 
                325                 330                 335     
Ala Ala Ser Ser Arg Ala Gly Ile Ala Pro Pro Leu Ala Leu Gly Ala 
            340                 345                 350         
Tyr Ser Pro Gly Gln Ser Ser Leu Tyr Ser Ser Pro Cys Ser Gln Thr 
        355                 360                 365             
Ser Ser Ala Gly Ser Ser Gly Gly Gly Gly Gly Gly Ala Gly Ala Ala 
    370                 375                 380                 
Gly Gly Ala Gly Gly Ala Gly Thr Tyr His Cys Asn Leu Gln Ala Met 
385                 390                 395                 400 
Ser Leu Tyr Ala Ala Gly Glu Arg Gly Gly His Leu Gln Gly Ala Pro 
                405                 410                 415     
Gly Gly Ala Gly Gly Ser Ala Val Asp Asp Pro Leu Pro Asp Tyr Ser 
            420                 425                 430         
Leu Pro Pro Val Thr Ser Ser Ser Ser Ser Ser Leu Ser His Gly Gly 
        435                 440                 445             
Gly Gly Gly Gly Gly Gly Gly Gly Gln Glu Ala Gly His His Pro Ala 
    450                 455                 460                 
Ala His Gln Gly Arg Leu Thr Ser Trp Tyr Leu Asn Gln Ala Gly Gly 
465                 470                 475                 480 
Asp Leu Gly His Leu Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Gly 
                485                 490                 495     
Tyr Pro Gly Gln Gln Gln Asn Phe His Ser Val Arg Glu Met Phe Glu 
            500                 505                 510         
Ser Gln Arg Ile Gly Leu Asn Asn Ser Pro Val Asn Gly Asn Ser Ser 
        515                 520                 525             
Cys Gln Met Ala Phe Pro Ser Ser Gln Ser Leu Tyr Arg Thr Ser Gly 
    530                 535                 540                 
Ala Phe Val Tyr Asp Cys Ser Lys Phe 
545                 550             

<210> 6
<211> 1662
<212> DNA
<213> Homo sapiens


<220> 
<223> FOXC1 - polynucleotide

<400> 6
atgcaggcgc gctactccgt gtccagcccc aactccctgg gagtggtgcc ctacctcggc      60

ggcgagcaga gctactaccg cgcggcggcc gcggcggccg ggggcggcta caccgccatg     120

ccggccccca tgagcgtgta ctcgcaccct gcgcacgccg agcagtaccc gggcggcatg     180

gcccgcgcct acgggcccta cacgccgcag ccgcagccca aggacatggt gaagccgccc     240

tatagctaca tcgcgctcat caccatggcc atccagaacg ccccggacaa gaagatcacc     300

ctgaacggca tctaccagtt catcatggac cgcttcccct tctaccggga caacaagcag     360

ggctggcaga acagcatccg ccacaacctc tcgctcaacg agtgcttcgt caaggtgccg     420

cgcgacgaca agaagccggg caagggcagc tactggacgc tggacccgga ctcctacaac     480

atgttcgaga acggcagctt cctgcggcgg cggcggcgct tcaagaagaa ggacgcggtg     540

aaggacaagg aggagaagga caggctgcac ctcaaggagc cgcccccgcc cggccgccag     600

cccccgcccg cgccgccgga gcaggccgac ggcaacgcgc ccggtccgca gccgccgccc     660

gtgcgcatcc aggacatcaa gaccgagaac ggtacgtgcc cctcgccgcc ccagcccctg     720

tccccggccg ccgccctggg cagcggcagc gccgccgcgg tgcccaagat cgagagcccc     780

gacagcagca gcagcagcct gtccagcggg agcagccccc cgggcagcct gccgtcggcg     840

cggccgctca gcctggacgg tgcggattcc gcgccgccgc cgcccgcgcc ctccgccccg     900

ccgccgcacc atagccaggg cttcagcgtg gacaacatca tgacgtcgct gcgggggtcg     960

ccgcagagcg cggccgcgga gctcagctcc ggccttctgg cctcggcggc cgcgtcctcg    1020

cgcgcgggga tcgcaccccc gctggcgctc ggcgcctact cgcccggcca gagctccctc    1080

tacagctccc cctgcagcca gacctccagc gcgggcagct cgggcggcgg cggcggcggc    1140

gcgggggccg cggggggcgc gggcggcgcc gggacctacc actgcaacct gcaagccatg    1200

agcctgtacg cggccggcga gcgcgggggc cacttgcagg gcgcgcccgg gggcgcgggc    1260

ggctcggccg tggacgaccc cctgcccgac tactctctgc ctccggtcac cagcagcagc    1320

tcgtcgtccc tgagtcacgg cggcggcggc ggcggcggcg ggggaggcca ggaggccggc    1380

caccaccctg cggcccacca aggccgcctc acctcgtggt acctgaacca ggcgggcgga    1440

gacctgggcc acttggcgag cgcggcggcg gcggcggcgg ccgcaggcta cccgggccag    1500

cagcagaact tccactcggt gcgggagatg ttcgagtcac agaggatcgg cttgaacaac    1560

tctccagtga acgggaatag tagctgtcaa atggccttcc cttccagcca gtctctgtac    1620

cgcacgtccg gagctttcgt ctacgactgt agcaagtttt ga                       1662


<210> 7
<211> 933
<212> PRT
<213> Homo sapiens


<220> 
<223> PGR - polypeptide

<400> 7
Met Thr Glu Leu Lys Ala Lys Gly Pro Arg Ala Pro His Val Ala Gly 
1               5                   10                  15      
Gly Pro Pro Ser Pro Glu Val Gly Ser Pro Leu Leu Cys Arg Pro Ala 
            20                  25                  30          
Ala Gly Pro Phe Pro Gly Ser Gln Thr Ser Asp Thr Leu Pro Glu Val 
        35                  40                  45              
Ser Ala Ile Pro Ile Ser Leu Asp Gly Leu Leu Phe Pro Arg Pro Cys 
    50                  55                  60                  
Gln Gly Gln Asp Pro Ser Asp Glu Lys Thr Gln Asp Gln Gln Ser Leu 
65                  70                  75                  80  
Ser Asp Val Glu Gly Ala Tyr Ser Arg Ala Glu Ala Thr Arg Gly Ala 
                85                  90                  95      
Gly Gly Ser Ser Ser Ser Pro Pro Glu Lys Asp Ser Gly Leu Leu Asp 
            100                 105                 110         
Ser Val Leu Asp Thr Leu Leu Ala Pro Ser Gly Pro Gly Gln Ser Gln 
        115                 120                 125             
Pro Ser Pro Pro Ala Cys Glu Val Thr Ser Ser Trp Cys Leu Phe Gly 
    130                 135                 140                 
Pro Glu Leu Pro Glu Asp Pro Pro Ala Ala Pro Ala Thr Gln Arg Val 
145                 150                 155                 160 
Leu Ser Pro Leu Met Ser Arg Ser Gly Cys Lys Val Gly Asp Ser Ser 
                165                 170                 175     
Gly Thr Ala Ala Ala His Lys Val Leu Pro Arg Gly Leu Ser Pro Ala 
            180                 185                 190         
Arg Gln Leu Leu Leu Pro Ala Ser Glu Ser Pro His Trp Ser Gly Ala 
        195                 200                 205             
Pro Val Lys Pro Ser Pro Gln Ala Ala Ala Val Glu Val Glu Glu Glu 
    210                 215                 220                 
Asp Gly Ser Glu Ser Glu Glu Ser Ala Gly Pro Leu Leu Lys Gly Lys 
225                 230                 235                 240 
Pro Arg Ala Leu Gly Gly Ala Ala Ala Gly Gly Gly Ala Ala Ala Val 
                245                 250                 255     
Pro Pro Gly Ala Ala Ala Gly Gly Val Ala Leu Val Pro Lys Glu Asp 
            260                 265                 270         
Ser Arg Phe Ser Ala Pro Arg Val Ala Leu Val Glu Gln Asp Ala Pro 
        275                 280                 285             
Met Ala Pro Gly Arg Ser Pro Leu Ala Thr Thr Val Met Asp Phe Ile 
    290                 295                 300                 
His Val Pro Ile Leu Pro Leu Asn His Ala Leu Leu Ala Ala Arg Thr 
305                 310                 315                 320 
Arg Gln Leu Leu Glu Asp Glu Ser Tyr Asp Gly Gly Ala Gly Ala Ala 
                325                 330                 335     
Ser Ala Phe Ala Pro Pro Arg Ser Ser Pro Cys Ala Ser Ser Thr Pro 
            340                 345                 350         
Val Ala Val Gly Asp Phe Pro Asp Cys Ala Tyr Pro Pro Asp Ala Glu 
        355                 360                 365             
Pro Lys Asp Asp Ala Tyr Pro Leu Tyr Ser Asp Phe Gln Pro Pro Ala 
    370                 375                 380                 
Leu Lys Ile Lys Glu Glu Glu Glu Gly Ala Glu Ala Ser Ala Arg Ser 
385                 390                 395                 400 
Pro Arg Ser Tyr Leu Val Ala Gly Ala Asn Pro Ala Ala Phe Pro Asp 
                405                 410                 415     
Phe Pro Leu Gly Pro Pro Pro Pro Leu Pro Pro Arg Ala Thr Pro Ser 
            420                 425                 430         
Arg Pro Gly Glu Ala Ala Val Thr Ala Ala Pro Ala Ser Ala Ser Val 
        435                 440                 445             
Ser Ser Ala Ser Ser Ser Gly Ser Thr Leu Glu Cys Ile Leu Tyr Lys 
    450                 455                 460                 
Ala Glu Gly Ala Pro Pro Gln Gln Gly Pro Phe Ala Pro Pro Pro Cys 
465                 470                 475                 480 
Lys Ala Pro Gly Ala Ser Gly Cys Leu Leu Pro Arg Asp Gly Leu Pro 
                485                 490                 495     
Ser Thr Ser Ala Ser Ala Ala Ala Ala Gly Ala Ala Pro Ala Leu Tyr 
            500                 505                 510         
Pro Ala Leu Gly Leu Asn Gly Leu Pro Gln Leu Gly Tyr Gln Ala Ala 
        515                 520                 525             
Val Leu Lys Glu Gly Leu Pro Gln Val Tyr Pro Pro Tyr Leu Asn Tyr 
    530                 535                 540                 
Leu Arg Pro Asp Ser Glu Ala Ser Gln Ser Pro Gln Tyr Ser Phe Glu 
545                 550                 555                 560 
Ser Leu Pro Gln Lys Ile Cys Leu Ile Cys Gly Asp Glu Ala Ser Gly 
                565                 570                 575     
Cys His Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys 
            580                 585                 590         
Arg Ala Met Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp 
        595                 600                 605             
Cys Ile Val Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Leu 
    610                 615                 620                 
Arg Lys Cys Cys Gln Ala Gly Met Val Leu Gly Gly Arg Lys Phe Lys 
625                 630                 635                 640 
Lys Phe Asn Lys Val Arg Val Val Arg Ala Leu Asp Ala Val Ala Leu 
                645                 650                 655     
Pro Gln Pro Val Gly Val Pro Asn Glu Ser Gln Ala Leu Ser Gln Arg 
            660                 665                 670         
Phe Thr Phe Ser Pro Gly Gln Asp Ile Gln Leu Ile Pro Pro Leu Ile 
        675                 680                 685             
Asn Leu Leu Met Ser Ile Glu Pro Asp Val Ile Tyr Ala Gly His Asp 
    690                 695                 700                 
Asn Thr Lys Pro Asp Thr Ser Ser Ser Leu Leu Thr Ser Leu Asn Gln 
705                 710                 715                 720 
Leu Gly Glu Arg Gln Leu Leu Ser Val Val Lys Trp Ser Lys Ser Leu 
                725                 730                 735     
Pro Gly Phe Arg Asn Leu His Ile Asp Asp Gln Ile Thr Leu Ile Gln 
            740                 745                 750         
Tyr Ser Trp Met Ser Leu Met Val Phe Gly Leu Gly Trp Arg Ser Tyr 
        755                 760                 765             
Lys His Val Ser Gly Gln Met Leu Tyr Phe Ala Pro Asp Leu Ile Leu 
    770                 775                 780                 
Asn Glu Gln Arg Met Lys Glu Ser Ser Phe Tyr Ser Leu Cys Leu Thr 
785                 790                 795                 800 
Met Trp Gln Ile Pro Gln Glu Phe Val Lys Leu Gln Val Ser Gln Glu 
                805                 810                 815     
Glu Phe Leu Cys Met Lys Val Leu Leu Leu Leu Asn Thr Ile Pro Leu 
            820                 825                 830         
Glu Gly Leu Arg Ser Gln Thr Gln Phe Glu Glu Met Arg Ser Ser Tyr 
        835                 840                 845             
Ile Arg Glu Leu Ile Lys Ala Ile Gly Leu Arg Gln Lys Gly Val Val 
    850                 855                 860                 
Ser Ser Ser Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Asn Leu 
865                 870                 875                 880 
His Asp Leu Val Lys Gln Leu His Leu Tyr Cys Leu Asn Thr Phe Ile 
                885                 890                 895     
Gln Ser Arg Ala Leu Ser Val Glu Phe Pro Glu Met Met Ser Glu Val 
            900                 905                 910         
Ile Ala Ala Gln Leu Pro Lys Ile Leu Ala Gly Met Val Lys Pro Leu 
        915                 920                 925             
Leu Phe His Lys Lys 
    930             

<210> 8
<211> 2802
<212> DNA
<213> Homo sapiens


<220> 
<223> PGR - polynucleotide

<400> 8
atgactgagc tgaaggcaaa gggtccccgg gctccccacg tggcgggcgg cccgccctcc      60

cccgaggtcg gatccccact gctgtgtcgc ccagccgcag gtccgttccc ggggagccag     120

acctcggaca ccttgcctga agtttcggcc atacctatct ccctggacgg gctactcttc     180

cctcggccct gccagggaca ggacccctcc gacgaaaaga cgcaggacca gcagtcgctg     240

tcggacgtgg agggcgcata ttccagagct gaagctacaa ggggtgctgg aggcagcagt     300

tctagtcccc cagaaaagga cagcggactg ctggacagtg tcttggacac tctgttggcg     360

ccctcaggtc ccgggcagag ccaacccagc cctcccgcct gcgaggtcac cagctcttgg     420

tgcctgtttg gccccgaact tcccgaagat ccaccggctg cccccgccac ccagcgggtg     480

ttgtccccgc tcatgagccg gtccgggtgc aaggttggag acagctccgg gacggcagct     540

gcccataaag tgctgccccg gggcctgtca ccagcccggc agctgctgct cccggcctct     600

gagagccctc actggtccgg ggccccagtg aagccgtctc cgcaggccgc tgcggtggag     660

gttgaggagg aggatggctc tgagtccgag gagtctgcgg gtccgcttct gaagggcaaa     720

cctcgggctc tgggtggcgc ggcggctgga ggaggagccg cggctgtccc gccgggggcg     780

gcagcaggag gcgtcgccct ggtccccaag gaagattccc gcttctcagc gcccagggtc     840

gccctggtgg agcaggacgc gccgatggcg cccgggcgct ccccgctggc caccacggtg     900

atggatttca tccacgtgcc tatcctgcct ctcaatcacg ccttattggc agcccgcact     960

cggcagctgc tggaagacga aagttacgac ggcggggccg gggctgccag cgcctttgcc    1020

ccgccgcgga gttcaccctg tgcctcgtcc accccggtcg ctgtaggcga cttccccgac    1080

tgcgcgtacc cgcccgacgc cgagcccaag gacgacgcgt accctctcta tagcgacttc    1140

cagccgcccg ctctaaagat aaaggaggag gaggaaggcg cggaggcctc cgcgcgctcc    1200

ccgcgttcct accttgtggc cggtgccaac cccgcagcct tcccggattt cccgttgggg    1260

ccaccgcccc cgctgccgcc gcgagcgacc ccatccagac ccggggaagc ggcggtgacg    1320

gccgcacccg ccagtgcctc agtctcgtct gcgtcctcct cggggtcgac cctggagtgc    1380

atcctgtaca aagcggaggg cgcgccgccc cagcagggcc cgttcgcgcc gccgccctgc    1440

aaggcgccgg gcgcgagcgg ctgcctgctc ccgcgggacg gcctgccctc cacctccgcc    1500

tctgccgccg ccgccggggc ggcccccgcg ctctaccctg cactcggcct caacgggctc    1560

ccgcagctcg gctaccaggc cgccgtgctc aaggagggcc tgccgcaggt ctacccgccc    1620

tatctcaact acctgaggcc ggattcagaa gccagccaga gcccacaata cagcttcgag    1680

tcattacctc agaagatttg tttaatctgt ggggatgaag catcaggctg tcattatggt    1740

gtccttacct gtgggagctg taaggtcttc tttaagaggg caatggaagg gcagcacaac    1800

tacttatgtg ctggaagaaa tgactgcatc gttgataaaa tccgcagaaa aaactgccca    1860

gcatgtcgcc ttagaaagtg ctgtcaggct ggcatggtcc ttggaggtcg aaaatttaaa    1920

aagttcaata aagtcagagt tgtgagagca ctggatgctg ttgctctccc acagccagtg    1980

ggcgttccaa atgaaagcca agccctaagc cagagattca ctttttcacc aggtcaagac    2040

atacagttga ttccaccact gatcaacctg ttaatgagca ttgaaccaga tgtgatctat    2100

gcaggacatg acaacacaaa acctgacacc tccagttctt tgctgacaag tcttaatcaa    2160

ctaggcgaga ggcaacttct ttcagtagtc aagtggtcta aatcattgcc aggttttcga    2220

aacttacata ttgatgacca gataactctc attcagtatt cttggatgag cttaatggtg    2280

tttggtctag gatggagatc ctacaaacac gtcagtgggc agatgctgta ttttgcacct    2340

gatctaatac taaatgaaca gcggatgaaa gaatcatcat tctattcatt atgccttacc    2400

atgtggcaga tcccacagga gtttgtcaag cttcaagtta gccaagaaga gttcctctgt    2460

atgaaagtat tgttacttct taatacaatt cctttggaag ggctacgaag tcaaacccag    2520

tttgaggaga tgaggtcaag ctacattaga gagctcatca aggcaattgg tttgaggcaa    2580

aaaggagttg tgtcgagctc acagcgtttc tatcaactta caaaacttct tgataacttg    2640

catgatcttg tcaaacaact tcatctgtac tgcttgaata catttatcca gtcccgggca    2700

ctgagtgttg aatttccaga aatgatgtct gaagttattg ctgcacaatt acccaagata    2760

ttggcaggga tggtgaaacc ccttctcttt cataaaaagt ga                       2802


<210> 9
<211> 403
<212> PRT
<213> Homo sapiens


<220> 
<223> AURKA - polypeptide

<400> 9
Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      
Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          
Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              
Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  
Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  
Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      
Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         
Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             
Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 
Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 
Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     
Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         
Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             
Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 
Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 
Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     
Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         
Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             
Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 
Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 
Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     
Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         
Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             
Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 
Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 
Lys Gln Ser 
            

<210> 10
<211> 1212
<212> DNA
<213> Homo sapiens


<220> 
<223> AURKA - polynucleotide

<400> 10
atggaccgat ctaaagaaaa ctgcatttca ggacctgtta aggctacagc tccagttgga      60

ggtccaaaac gtgttctcgt gactcagcaa tttccttgtc agaatccatt acctgtaaat     120

agtggccagg ctcagcgggt cttgtgtcct tcaaattctt cccagcgcat tcctttgcaa     180

gcacaaaagc ttgtctccag tcacaagccg gttcagaatc agaagcagaa gcaattgcag     240

gcaaccagtg tacctcatcc tgtctccagg ccactgaata acacccaaaa gagcaagcag     300

cccctgccat cggcacctga aaataatcct gaggaggaac tggcatcaaa acagaaaaat     360

gaagaatcaa aaaagaggca gtgggctttg gaagactttg aaattggtcg ccctctgggt     420

aaaggaaagt ttggtaatgt ttatttggca agagaaaagc aaagcaagtt tattctggct     480

cttaaagtgt tatttaaagc tcagctggag aaagccggag tggagcatca gctcagaaga     540

gaagtagaaa tacagtccca ccttcggcat cctaatattc ttagactgta tggttatttc     600

catgatgcta ccagagtcta cctaattctg gaatatgcac cacttggaac agtttataga     660

gaacttcaga aactttcaaa gtttgatgag cagagaactg ctacttatat aacagaattg     720

gcaaatgccc tgtcttactg tcattcgaag agagttattc atagagacat taagccagag     780

aacttacttc ttggatcagc tggagagctt aaaattgcag attttgggtg gtcagtacat     840

gctccatctt ccaggaggac cactctctgt ggcaccctgg actacctgcc ccctgaaatg     900

attgaaggtc ggatgcatga tgagaaggtg gatctctgga gccttggagt tctttgctat     960

gaatttttag ttgggaagcc tccttttgag gcaaacacat accaagagac ctacaaaaga    1020

atatcacggg ttgaattcac attccctgac tttgtaacag agggagccag ggacctcatt    1080

tcaagactgt tgaagcataa tcccagccag aggccaatgc tcagagaagt acttgaacac    1140

ccctggatca cagcaaattc atcaaaacca tcaaattgcc aaaacaaaga atcagctagc    1200

aaacagtctt ag                                                        1212


<210> 11
<211> 725
<212> PRT
<213> Homo sapiens


<220> 
<223> KIF2C - polypeptide

<400> 11
Met Ala Met Asp Ser Ser Leu Gln Ala Arg Leu Phe Pro Gly Leu Ala 
1               5                   10                  15      
Ile Lys Ile Gln Arg Ser Asn Gly Leu Ile His Ser Ala Asn Val Arg 
            20                  25                  30          
Thr Val Asn Leu Glu Lys Ser Cys Val Ser Val Glu Trp Ala Glu Gly 
        35                  40                  45              
Gly Ala Thr Lys Gly Lys Glu Ile Asp Phe Asp Asp Val Ala Ala Ile 
    50                  55                  60                  
Asn Pro Glu Leu Leu Gln Leu Leu Pro Leu His Pro Lys Asp Asn Leu 
65                  70                  75                  80  
Pro Leu Gln Glu Asn Val Thr Ile Gln Lys Gln Lys Arg Arg Ser Val 
                85                  90                  95      
Asn Ser Lys Ile Pro Ala Pro Lys Glu Ser Leu Arg Ser Arg Ser Thr 
            100                 105                 110         
Arg Met Ser Thr Val Ser Glu Leu Arg Ile Thr Ala Gln Glu Asn Asp 
        115                 120                 125             
Met Glu Val Glu Leu Pro Ala Ala Ala Asn Ser Arg Lys Gln Phe Ser 
    130                 135                 140                 
Val Pro Pro Ala Pro Thr Arg Pro Ser Cys Pro Ala Val Ala Glu Ile 
145                 150                 155                 160 
Pro Leu Arg Met Val Ser Glu Glu Met Glu Glu Gln Val His Ser Ile 
                165                 170                 175     
Arg Gly Ser Ser Ser Ala Asn Pro Val Asn Ser Val Arg Arg Lys Ser 
            180                 185                 190         
Cys Leu Val Lys Glu Val Glu Lys Met Lys Asn Lys Arg Glu Glu Lys 
        195                 200                 205             
Lys Ala Gln Asn Ser Glu Met Arg Met Lys Arg Ala Gln Glu Tyr Asp 
    210                 215                 220                 
Ser Ser Phe Pro Asn Trp Glu Phe Ala Arg Met Ile Lys Glu Phe Arg 
225                 230                 235                 240 
Ala Thr Leu Glu Cys His Pro Leu Thr Met Thr Asp Pro Ile Glu Glu 
                245                 250                 255     
His Arg Ile Cys Val Cys Val Arg Lys Arg Pro Leu Asn Lys Gln Glu 
            260                 265                 270         
Leu Ala Lys Lys Glu Ile Asp Val Ile Ser Ile Pro Ser Lys Cys Leu 
        275                 280                 285             
Leu Leu Val His Glu Pro Lys Leu Lys Val Asp Leu Thr Lys Tyr Leu 
    290                 295                 300                 
Glu Asn Gln Ala Phe Cys Phe Asp Phe Ala Phe Asp Glu Thr Ala Ser 
305                 310                 315                 320 
Asn Glu Val Val Tyr Arg Phe Thr Ala Arg Pro Leu Val Gln Thr Ile 
                325                 330                 335     
Phe Glu Gly Gly Lys Ala Thr Cys Phe Ala Tyr Gly Gln Thr Gly Ser 
            340                 345                 350         
Gly Lys Thr His Thr Met Gly Gly Asp Leu Ser Gly Lys Ala Gln Asn 
        355                 360                 365             
Ala Ser Lys Gly Ile Tyr Ala Met Ala Ser Arg Asp Val Phe Leu Leu 
    370                 375                 380                 
Lys Asn Gln Pro Cys Tyr Arg Lys Leu Gly Leu Glu Val Tyr Val Thr 
385                 390                 395                 400 
Phe Phe Glu Ile Tyr Asn Gly Lys Leu Phe Asp Leu Leu Asn Lys Lys 
                405                 410                 415     
Ala Lys Leu Arg Val Leu Glu Asp Gly Lys Gln Gln Val Gln Val Val 
            420                 425                 430         
Gly Leu Gln Glu His Leu Val Asn Ser Ala Asp Asp Val Ile Lys Met 
        435                 440                 445             
Ile Asp Met Gly Ser Ala Cys Arg Thr Ser Gly Gln Thr Phe Ala Asn 
    450                 455                 460                 
Ser Asn Ser Ser Arg Ser His Ala Cys Phe Gln Ile Ile Leu Arg Ala 
465                 470                 475                 480 
Lys Gly Arg Met His Gly Lys Phe Ser Leu Val Asp Leu Ala Gly Asn 
                485                 490                 495     
Glu Arg Gly Ala Asp Thr Ser Ser Ala Asp Arg Gln Thr Arg Met Glu 
            500                 505                 510         
Gly Ala Glu Ile Asn Lys Ser Leu Leu Ala Leu Lys Glu Cys Ile Arg 
        515                 520                 525             
Ala Leu Gly Gln Asn Lys Ala His Thr Pro Phe Arg Glu Ser Lys Leu 
    530                 535                 540                 
Thr Gln Val Leu Arg Asp Ser Phe Ile Gly Glu Asn Ser Arg Thr Cys 
545                 550                 555                 560 
Met Ile Ala Thr Ile Ser Pro Gly Ile Ser Ser Cys Glu Tyr Thr Leu 
                565                 570                 575     
Asn Thr Leu Arg Tyr Ala Asp Arg Val Lys Glu Leu Ser Pro His Ser 
            580                 585                 590         
Gly Pro Ser Gly Glu Gln Leu Ile Gln Met Glu Thr Glu Glu Met Glu 
        595                 600                 605             
Ala Cys Ser Asn Gly Ala Leu Ile Pro Gly Asn Leu Ser Lys Glu Glu 
    610                 615                 620                 
Glu Glu Leu Ser Ser Gln Met Ser Ser Phe Asn Glu Ala Met Thr Gln 
625                 630                 635                 640 
Ile Arg Glu Leu Glu Glu Lys Ala Met Glu Glu Leu Lys Glu Ile Ile 
                645                 650                 655     
Gln Gln Gly Pro Asp Trp Leu Glu Leu Ser Glu Met Thr Glu Gln Pro 
            660                 665                 670         
Asp Tyr Asp Leu Glu Thr Phe Val Asn Lys Ala Glu Ser Ala Leu Ala 
        675                 680                 685             
Gln Gln Ala Lys His Phe Ser Ala Leu Arg Asp Val Ile Lys Ala Leu 
    690                 695                 700                 
Arg Leu Ala Met Gln Leu Glu Glu Gln Ala Ser Arg Gln Ile Ser Ser 
705                 710                 715                 720 
Lys Lys Arg Pro Gln 
                725 

<210> 12
<211> 2178
<212> DNA
<213> Homo sapiens


<220> 
<223> KIF2C - polynucleotide

<400> 12
atggccatgg actcgtcgct tcaggcccgc ctgtttcccg gtctcgctat caagatccaa      60

cgcagtaatg gtttaattca cagtgccaat gtaaggactg tgaacttgga gaaatcctgt     120

gtttcagtgg aatgggcaga aggaggtgcc acaaagggca aagagattga ttttgatgat     180

gtggctgcaa taaacccaga actcttacag cttcttccct tacatccgaa ggacaatctg     240

cccttgcagg aaaatgtaac aatccagaaa caaaaacgga gatccgtcaa ctccaaaatt     300

cctgctccaa aagaaagtct tcgaagccgc tccactcgca tgtccactgt ctcagagctt     360

cgcatcacgg ctcaggagaa tgacatggag gtggagctgc ctgcagctgc aaactcccgc     420

aagcagtttt cagttcctcc tgcccccact aggccttcct gccctgcagt ggctgaaata     480

ccattgagga tggtcagcga ggagatggaa gagcaagtcc attccatccg aggcagctct     540

tctgcaaacc ctgtgaactc agttcggagg aaatcatgtc ttgtgaagga agtggaaaaa     600

atgaagaaca agcgagaaga gaagaaggcc cagaactctg aaatgagaat gaagagagct     660

caggagtatg acagtagttt tccaaactgg gaatttgccc gaatgattaa agaatttcgg     720

gctactttgg aatgtcatcc acttactatg actgatccta tcgaagagca cagaatatgt     780

gtctgtgtta ggaaacgccc actgaataag caagaattgg ccaagaaaga aattgatgtg     840

atttccattc ctagcaagtg tctcctcttg gtacatgaac ccaagttgaa agtggactta     900

acaaagtatc tggagaacca agcattctgc tttgactttg catttgatga aacagcttcg     960

aatgaagttg tctacaggtt cacagcaagg ccactggtac agacaatctt tgaaggtgga    1020

aaagcaactt gttttgcata tggccagaca ggaagtggca agacacatac tatgggcgga    1080

gacctctctg ggaaagccca gaatgcatcc aaagggatct atgccatggc ctcccgggac    1140

gtcttcctcc tgaagaatca accctgctac cggaagttgg gcctggaagt ctatgtgaca    1200

ttcttcgaga tctacaatgg gaagctgttt gacctgctca acaagaaggc caagctgcgc    1260

gtgctggagg acggcaagca acaggtgcaa gtggtggggc tgcaggagca tctggttaac    1320

tctgctgatg atgtcatcaa gatgatcgac atgggcagcg cctgcagaac ctctgggcag    1380

acatttgcca actccaattc ctcccgctcc cacgcgtgct tccaaattat tcttcgagct    1440

aaagggagaa tgcatggcaa gttctctttg gtagatctgg cagggaatga gcgaggcgcg    1500

gacacttcca gtgctgaccg gcagacccgc atggagggcg cagaaatcaa caagagtctc    1560

ttagccctga aggagtgcat cagggccctg ggacagaaca aggctcacac cccgttccgt    1620

gagagcaagc tgacacaggt gctgagggac tccttcattg gggagaactc taggacttgc    1680

atgattgcca cgatctcacc aggcataagc tcctgtgaat atactttaaa caccctgaga    1740

tatgcagaca gggtcaagga gctgagcccc cacagtgggc ccagtggaga gcagttgatt    1800

caaatggaaa cagaagagat ggaagcctgc tctaacgggg cgctgattcc aggcaattta    1860

tccaaggaag aggaggaact gtcttcccag atgtccagct ttaacgaagc catgactcag    1920

atcagggagc tggaggagaa ggctatggaa gagctcaagg agatcataca gcaaggacca    1980

gactggcttg agctctctga gatgaccgag cagccagact atgacctgga gacctttgtg    2040

aacaaagcgg aatctgctct ggcccagcaa gccaagcatt tctcagccct gcgagatgtc    2100

atcaaggcct tgcgcctggc catgcagctg gaagagcagg ctagcagaca aataagcagc    2160

aagaaacggc cccagtga                                                  2178


<210> 13
<211> 375
<212> PRT
<213> Homo sapiens


<220> 
<223> ACTB - polypeptide

<400> 13
Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      
Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          
Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              
Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  
Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  
Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      
Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         
Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             
Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 
Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 
His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     
Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         
Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             
Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 
Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 
Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     
Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         
Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             
Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 
Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 
Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     
Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         
Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             
Ile Val His Arg Lys Cys Phe 
    370                 375 

<210> 14
<211> 1128
<212> DNA
<213> Homo sapiens


<220> 
<223> ACTB - polynucleotide

<400> 14
atggatgatg atatcgccgc gctcgtcgtc gacaacggct ccggcatgtg caaggccggc      60

ttcgcgggcg acgatgcccc ccgggccgtc ttcccctcca tcgtggggcg ccccaggcac     120

cagggcgtga tggtgggcat gggtcagaag gattcctatg tgggcgacga ggcccagagc     180

aagagaggca tcctcaccct gaagtacccc atcgagcacg gcatcgtcac caactgggac     240

gacatggaga aaatctggca ccacaccttc tacaatgagc tgcgtgtggc tcccgaggag     300

caccccgtgc tgctgaccga ggcccccctg aaccccaagg ccaaccgcga gaagatgacc     360

cagatcatgt ttgagacctt caacacccca gccatgtacg ttgctatcca ggctgtgcta     420

tccctgtacg cctctggccg taccactggc atcgtgatgg actccggtga cggggtcacc     480

cacactgtgc ccatctacga ggggtatgcc ctcccccatg ccatcctgcg tctggacctg     540

gctggccggg acctgactga ctacctcatg aagatcctca ccgagcgcgg ctacagcttc     600

accaccacgg ccgagcggga aatcgtgcgt gacattaagg agaagctgtg ctacgtcgcc     660

ctggacttcg agcaagagat ggccacggct gcttccagct cctccctgga gaagagctac     720

gagctgcctg acggccaggt catcaccatt ggcaatgagc ggttccgctg ccctgaggca     780

ctcttccagc cttccttcct gggcatggag tcctgtggca tccacgaaac taccttcaac     840

tccatcatga agtgtgacgt ggacatccgc aaagacctgt acgccaacac agtgctgtct     900

ggcggcacca ccatgtaccc tggcattgcc gacaggatgc agaaggagat cactgccctg     960

gcacccagca caatgaagat caagatcatt gctcctcctg agcgcaagta ctccgtgtgg    1020

atcggcggct ccatcctggc ctcgctgtcc accttccagc agatgtggat cagcaagcag    1080

gagtatgacg agtccggccc ctccatcgtc caccgcaaat gcttctag                 1128


<210> 15
<211> 216
<212> PRT
<213> Homo sapiens


<220> 
<223> PPIB - polypeptide

<400> 15
Met Leu Arg Leu Ser Glu Arg Asn Met Lys Val Leu Leu Ala Ala Ala 
1               5                   10                  15      
Leu Ile Ala Gly Ser Val Phe Phe Leu Leu Leu Pro Gly Pro Ser Ala 
            20                  25                  30          
Ala Asp Glu Lys Lys Lys Gly Pro Lys Val Thr Val Lys Val Tyr Phe 
        35                  40                  45              
Asp Leu Arg Ile Gly Asp Glu Asp Val Gly Arg Val Ile Phe Gly Leu 
    50                  55                  60                  
Phe Gly Lys Thr Val Pro Lys Thr Val Asp Asn Phe Val Ala Leu Ala 
65                  70                  75                  80  
Thr Gly Glu Lys Gly Phe Gly Tyr Lys Asn Ser Lys Phe His Arg Val 
                85                  90                  95      
Ile Lys Asp Phe Met Ile Gln Gly Gly Asp Phe Thr Arg Gly Asp Gly 
            100                 105                 110         
Thr Gly Gly Lys Ser Ile Tyr Gly Glu Arg Phe Pro Asp Glu Asn Phe 
        115                 120                 125             
Lys Leu Lys His Tyr Gly Pro Gly Trp Val Ser Met Ala Asn Ala Gly 
    130                 135                 140                 
Lys Asp Thr Asn Gly Ser Gln Phe Phe Ile Thr Thr Val Lys Thr Ala 
145                 150                 155                 160 
Trp Leu Asp Gly Lys His Val Val Phe Gly Lys Val Leu Glu Gly Met 
                165                 170                 175     
Glu Val Val Arg Lys Val Glu Ser Thr Lys Thr Asp Ser Arg Asp Lys 
            180                 185                 190         
Pro Leu Lys Asp Val Ile Ile Ala Asp Cys Gly Lys Ile Glu Val Glu 
        195                 200                 205             
Lys Pro Phe Ala Ile Ala Lys Glu 
    210                 215     

<210> 16
<211> 651
<212> DNA
<213> Homo sapiens


<220> 
<223> PPIB - polynucleotide

<400> 16
atgctgcgcc tctccgaacg caacatgaag gtgctccttg ccgccgccct catcgcgggg      60

tccgtcttct tcctgctgct gccgggacct tctgcggccg atgagaagaa gaaggggccc     120

aaagtcaccg tcaaggtgta ttttgaccta cgaattggag atgaagatgt aggccgggtg     180

atctttggtc tcttcggaaa gactgttcca aaaacagtgg ataattttgt ggccttagct     240

acaggagaga aaggatttgg ctacaaaaac agcaaattcc atcgtgtaat caaggacttc     300

atgatccagg gcggagactt caccagggga gatggcacag gaggaaagag catctacggt     360

gagcgcttcc ccgatgagaa cttcaaactg aagcactacg ggcctggctg ggtgagcatg     420

gccaacgcag gcaaagacac caacggctcc cagttcttca tcacgacagt caagacagcc     480

tggctagatg gcaagcatgt ggtgtttggc aaagttctag agggcatgga ggtggtgcgg     540

aaggtggaga gcaccaagac agacagccgg gataaacccc tgaaggatgt gatcatcgca     600

gactgcggca agatcgaggt ggagaagccc tttgccatcg ccaaggagta g              651


<210> 17
<211> 218
<212> PRT
<213> Homo sapiens


<220> 
<223> HPRT1 - polypeptide

<400> 17
Met Ala Thr Arg Ser Pro Gly Val Val Ile Ser Asp Asp Glu Pro Gly 
1               5                   10                  15      
Tyr Asp Leu Asp Leu Phe Cys Ile Pro Asn His Tyr Ala Glu Asp Leu 
            20                  25                  30          
Glu Arg Val Phe Ile Pro His Gly Leu Ile Met Asp Arg Thr Glu Arg 
        35                  40                  45              
Leu Ala Arg Asp Val Met Lys Glu Met Gly Gly His His Ile Val Ala 
    50                  55                  60                  
Leu Cys Val Leu Lys Gly Gly Tyr Lys Phe Phe Ala Asp Leu Leu Asp 
65                  70                  75                  80  
Tyr Ile Lys Ala Leu Asn Arg Asn Ser Asp Arg Ser Ile Pro Met Thr 
                85                  90                  95      
Val Asp Phe Ile Arg Leu Lys Ser Tyr Cys Asn Asp Gln Ser Thr Gly 
            100                 105                 110         
Asp Ile Lys Val Ile Gly Gly Asp Asp Leu Ser Thr Leu Thr Gly Lys 
        115                 120                 125             
Asn Val Leu Ile Val Glu Asp Ile Ile Asp Thr Gly Lys Thr Met Gln 
    130                 135                 140                 
Thr Leu Leu Ser Leu Val Arg Gln Tyr Asn Pro Lys Met Val Lys Val 
145                 150                 155                 160 
Ala Ser Leu Leu Val Lys Arg Thr Pro Arg Ser Val Gly Tyr Lys Pro 
                165                 170                 175     
Asp Phe Val Gly Phe Glu Ile Pro Asp Lys Phe Val Val Gly Tyr Ala 
            180                 185                 190         
Leu Asp Tyr Asn Glu Tyr Phe Arg Asp Leu Asn His Val Cys Val Ile 
        195                 200                 205             
Ser Glu Thr Gly Lys Ala Lys Tyr Lys Ala 
    210                 215             

<210> 18
<211> 657
<212> DNA
<213> Homo sapiens


<220> 
<223> HPRT1 - polynucleotide

<400> 18
atggcgaccc gcagccctgg cgtcgtgatt agtgatgatg aaccaggtta tgaccttgat      60

ttattttgca tacctaatca ttatgctgag gatttggaaa gggtgtttat tcctcatgga     120

ctaattatgg acaggactga acgtcttgct cgagatgtga tgaaggagat gggaggccat     180

cacattgtag ccctctgtgt gctcaagggg ggctataaat tctttgctga cctgctggat     240

tacatcaaag cactgaatag aaatagtgat agatccattc ctatgactgt agattttatc     300

agactgaaga gctattgtaa tgaccagtca acaggggaca taaaagtaat tggtggagat     360

gatctctcaa ctttaactgg aaagaatgtc ttgattgtgg aagatataat tgacactggc     420

aaaacaatgc agactttgct ttccttggtc aggcagtata atccaaagat ggtcaaggtc     480

gcaagcttgc tggtgaaaag gaccccacga agtgttggat ataagccaga ctttgttgga     540

tttgaaattc cagacaagtt tgttgtagga tatgcccttg actataatga atacttcagg     600

gatttgaatc atgtttgtgt cattagtgaa actggaaaag caaaatacaa agcctaa        657


<210> 19
<211> 339
<212> PRT
<213> Homo sapiens


<220> 
<223> TBP - polypeptide

<400> 19
Met Asp Gln Asn Asn Ser Leu Pro Pro Tyr Ala Gln Gly Leu Ala Ser 
1               5                   10                  15      
Pro Gln Gly Ala Met Thr Pro Gly Ile Pro Ile Phe Ser Pro Met Met 
            20                  25                  30          
Pro Tyr Gly Thr Gly Leu Thr Pro Gln Pro Ile Gln Asn Thr Asn Ser 
        35                  40                  45              
Leu Ser Ile Leu Glu Glu Gln Gln Arg Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala 
                85                  90                  95      
Val Ala Ala Ala Ala Val Gln Gln Ser Thr Ser Gln Gln Ala Thr Gln 
            100                 105                 110         
Gly Thr Ser Gly Gln Ala Pro Gln Leu Phe His Ser Gln Thr Leu Thr 
        115                 120                 125             
Thr Ala Pro Leu Pro Gly Thr Thr Pro Leu Tyr Pro Ser Pro Met Thr 
    130                 135                 140                 
Pro Met Thr Pro Ile Thr Pro Ala Thr Pro Ala Ser Glu Ser Ser Gly 
145                 150                 155                 160 
Ile Val Pro Gln Leu Gln Asn Ile Val Ser Thr Val Asn Leu Gly Cys 
                165                 170                 175     
Lys Leu Asp Leu Lys Thr Ile Ala Leu Arg Ala Arg Asn Ala Glu Tyr 
            180                 185                 190         
Asn Pro Lys Arg Phe Ala Ala Val Ile Met Arg Ile Arg Glu Pro Arg 
        195                 200                 205             
Thr Thr Ala Leu Ile Phe Ser Ser Gly Lys Met Val Cys Thr Gly Ala 
    210                 215                 220                 
Lys Ser Glu Glu Gln Ser Arg Leu Ala Ala Arg Lys Tyr Ala Arg Val 
225                 230                 235                 240 
Val Gln Lys Leu Gly Phe Pro Ala Lys Phe Leu Asp Phe Lys Ile Gln 
                245                 250                 255     
Asn Met Val Gly Ser Cys Asp Val Lys Phe Pro Ile Arg Leu Glu Gly 
            260                 265                 270         
Leu Val Leu Thr His Gln Gln Phe Ser Ser Tyr Glu Pro Glu Leu Phe 
        275                 280                 285             
Pro Gly Leu Ile Tyr Arg Met Ile Lys Pro Arg Ile Val Leu Leu Ile 
    290                 295                 300                 
Phe Val Ser Gly Lys Val Val Leu Thr Gly Ala Lys Val Arg Ala Glu 
305                 310                 315                 320 
Ile Tyr Glu Ala Phe Glu Asn Ile Tyr Pro Ile Leu Lys Gly Phe Arg 
                325                 330                 335     
Lys Thr Thr 
            

<210> 20
<211> 1020
<212> DNA
<213> Homo sapiens


<220> 
<223> TBP - polynucleotide

<400> 20
atggatcaga acaacagcct gccaccttac gctcagggct tggcctcccc tcagggtgcc      60

atgactcccg gaatccctat ctttagtcca atgatgcctt atggcactgg actgacccca     120

cagcctattc agaacaccaa tagtctgtct attttggaag agcaacaaag gcagcagcag     180

caacaacaac agcagcagca gcagcagcag cagcaacagc aacagcagca gcagcagcag     240

cagcagcagc agcagcagca gcagcagcag cagcagcagc aacaggcagt ggcagctgca     300

gccgttcagc agtcaacgtc ccagcaggca acacagggaa cctcaggcca ggcaccacag     360

ctcttccact cacagactct cacaactgca cccttgccgg gcaccactcc actgtatccc     420

tcccccatga ctcccatgac ccccatcact cctgccacgc cagcttcgga gagttctggg     480

attgtaccgc agctgcaaaa tattgtatcc acagtgaatc ttggttgtaa acttgaccta     540

aagaccattg cacttcgtgc ccgaaacgcc gaatataatc ccaagcggtt tgctgcggta     600

atcatgagga taagagagcc acgaaccacg gcactgattt tcagttctgg gaaaatggtg     660

tgcacaggag ccaagagtga agaacagtcc agactggcag caagaaaata tgctagagtt     720

gtacagaagt tgggttttcc agctaagttc ttggacttca agattcagaa tatggtgggg     780

agctgtgatg tgaagtttcc tataaggtta gaaggccttg tgctcaccca ccaacaattt     840

agtagttatg agccagagtt atttcctggt ttaatctaca gaatgatcaa acccagaatt     900

gttctcctta tttttgtttc tggaaaagtt gtattaacag gtgctaaagt cagagcagaa     960

atttatgaag catttgaaaa catctaccct attctaaagg gattcaggaa gacgacgtaa    1020


