                         SEQUENCE LISTING

<110>  Yale University
       Wang, Andrew
       Liu, Wenjun
       Ring, Aaron
 
<120>  COMPOSITIONS FOR MODULATION OF A TREM OR TREML PROTEIN AND 
       METHODS OF USE

<130>  047162-5255-00-WO.608547

<150>  US 62/630,333
<151>  2018-02-14

<150>  US 62/771,730
<151>  2018-11-27

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of human TREML4

<400>  1

Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu Gln Cys Gln 
1               5                   10                  15      


Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp Cys Gln Gln 
            20                  25                  30          


Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser Lys Pro Trp 
        35                  40                  45              


Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys Pro Asn Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn Asp Ser Gly 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile Ile Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr Thr Ser Pro 
            100                 105                 110         


Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu Ile Thr Ser 
        115                 120                 125             


Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser Glu Thr Arg 
    130                 135                 140                 


Lys Ser Arg Ala Pro Ala 
145                 150 


<210>  2
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of hTREML4-K86D

<400>  2

Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu Gln Cys Gln 
1               5                   10                  15      


Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp Cys Gln Gln 
            20                  25                  30          


Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser Lys Pro Trp 
        35                  40                  45              


Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Asp Pro Asn Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn Asp Ser Gly 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile Ile Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr Thr Ser Pro 
            100                 105                 110         


Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu Ile Thr Ser 
        115                 120                 125             


Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser Glu Thr Arg 
    130                 135                 140                 


Lys Ser Arg Ala Pro Ala 
145                 150 


<210>  3
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of hTREML4-L65R

<400>  3

Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu Gln Cys Gln 
1               5                   10                  15      


Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp Cys Gln Gln 
            20                  25                  30          


Thr Ser Pro Ser Arg Cys Thr Arg Leu Val Thr Ser Ser Lys Pro Trp 
        35                  40                  45              


Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys Pro Asn Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn Asp Ser Gly 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile Ile Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr Thr Ser Pro 
            100                 105                 110         


Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu Ile Thr Ser 
        115                 120                 125             


Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser Glu Thr Arg 
    130                 135                 140                 


Lys Ser Arg Ala Pro Ala 
145                 150 


<210>  4
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of hTREML4-K71E

<400>  4

Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu Gln Cys Gln 
1               5                   10                  15      


Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp Cys Gln Gln 
            20                  25                  30          


Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser Glu Pro Trp 
        35                  40                  45              


Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys Pro Asn Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn Asp Ser Gly 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile Ile Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr Thr Ser Pro 
            100                 105                 110         


Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu Ile Thr Ser 
        115                 120                 125             


Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser Glu Thr Arg 
    130                 135                 140                 


Lys Ser Arg Ala Pro 
145                 


<210>  5
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of hTREML4-T95K

<400>  5

Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu Gln Cys Gln 
1               5                   10                  15      


Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp Cys Gln Gln 
            20                  25                  30          


Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser Lys Pro Trp 
        35                  40                  45              


Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys Pro Asn Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Lys Met Ile Gln Leu Thr Gln Asn Asp Ser Gly 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile Ile Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr Thr Ser Pro 
            100                 105                 110         


Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu Ile Thr Ser 
        115                 120                 125             


Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser Glu Thr Arg 
    130                 135                 140                 


Lys Ser Arg Ala Pro Ala 
145                 150 


<210>  6
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of hTREML4-T35S

<400>  6

Glu Glu Leu His Lys His Pro Gly Gln Ser Leu Leu Leu Gln Cys Gln 
1               5                   10                  15      


Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp Cys Gln Gln 
            20                  25                  30          


Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser Lys Pro Trp 
        35                  40                  45              


Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys Pro Asn Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn Asp Ser Gly 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile Ile Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr Thr Ser Pro 
            100                 105                 110         


Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu Ile Thr Ser 
        115                 120                 125             


Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser Glu Thr Arg 
    130                 135                 140                 


Lys Ser Arg Ala Pro Ala 
145                 150 


<210>  7
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of hTREML4-L66V

<400>  7

Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu Gln Cys Gln 
1               5                   10                  15      


Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp Cys Gln Gln 
            20                  25                  30          


Thr Ser Pro Ser Arg Cys Thr Leu Val Val Thr Ser Ser Lys Pro Trp 
        35                  40                  45              


Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys Pro Asn Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn Asp Ser Gly 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile Ile Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr Thr Ser Pro 
            100                 105                 110         


Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu Ile Thr Ser 
        115                 120                 125             


Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser Glu Thr Arg 
    130                 135                 140                 


Lys Ser Arg Ala Pro Ala 
145                 150 


<210>  8
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of hTREML4-S69T

<400>  8

Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu Gln Cys Gln 
1               5                   10                  15      


Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp Cys Gln Gln 
            20                  25                  30          


Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Thr Ser Lys Pro Trp 
        35                  40                  45              


Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys Pro Asn Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn Asp Ser Gly 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile Ile Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr Thr Ser Pro 
            100                 105                 110         


Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu Ile Thr Ser 
        115                 120                 125             


Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser Glu Thr Arg 
    130                 135                 140                 


Lys Ser Arg Ala Pro Ala 
145                 150 


<210>  9
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of hTREML4-K78E

<400>  9

Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu Gln Cys Gln 
1               5                   10                  15      


Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp Cys Gln Gln 
            20                  25                  30          


Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser Lys Pro Trp 
        35                  40                  45              


Thr Ala Val Gln Glu Ser His Tyr Thr Ile Trp Asp Lys Pro Asn Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn Asp Ser Gly 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile Ile Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr Thr Ser Pro 
            100                 105                 110         


Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu Ile Thr Ser 
        115                 120                 125             


Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser Glu Thr Arg 
    130                 135                 140                 


Lys Ser Arg Ala Pro Ala 
145                 150 


<210>  10
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of hTREML4-G156E

<400>  10

Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu Gln Cys Gln 
1               5                   10                  15      


Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp Cys Gln Gln 
            20                  25                  30          


Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser Lys Pro Trp 
        35                  40                  45              


Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys Pro Asn Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn Asp Ser Gly 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile Ile Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr Thr Ser Pro 
            100                 105                 110         


Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu Ile Thr Ser 
        115                 120                 125             


Pro Glu Glu Thr Ser Gly His Pro Ser Ile Asn Gly Ser Glu Thr Arg 
    130                 135                 140                 


Lys Ser Arg Ala Pro Ala 
145                 150 


<210>  11
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of hTREML4-H160D

<400>  11

Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu Gln Cys Gln 
1               5                   10                  15      


Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp Cys Gln Gln 
            20                  25                  30          


Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser Lys Pro Trp 
        35                  40                  45              


Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys Pro Asn Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn Asp Ser Gly 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile Ile Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr Thr Ser Pro 
            100                 105                 110         


Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu Ile Thr Ser 
        115                 120                 125             


Pro Glu Gly Thr Ser Gly Asp Pro Ser Ile Asn Gly Ser Glu Thr Arg 
    130                 135                 140                 


Lys Ser Arg Ala Pro Ala 
145                 150 


<210>  12
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of hTREML4-L65R/K71E/K86D

<400>  12

Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu Gln Cys Gln 
1               5                   10                  15      


Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp Cys Gln Gln 
            20                  25                  30          


Thr Ser Pro Ser Arg Cys Thr Arg Leu Val Thr Ser Ser Glu Pro Trp 
        35                  40                  45              


Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Asp Pro Asn Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn Asp Ser Gly 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile Ile Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr Thr Ser Pro 
            100                 105                 110         


Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu Ile Thr Ser 
        115                 120                 125             


Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser Glu Thr Arg 
    130                 135                 140                 


Lys Ser Arg Ala Pro Ala 
145                 150 


<210>  13
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of hTREML4-L65R/K71E/K86D/T95K

<400>  13

Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu Gln Cys Gln 
1               5                   10                  15      


Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp Cys Gln Gln 
            20                  25                  30          


Thr Ser Pro Ser Arg Cys Thr Arg Leu Val Thr Ser Ser Glu Pro Trp 
        35                  40                  45              


Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Asp Pro Asn Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Lys Met Ile Gln Leu Thr Gln Asn Asp Ser Gly 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile Ile Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr Thr Ser Pro 
            100                 105                 110         


Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu Ile Thr Ser 
        115                 120                 125             


Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser Glu Thr Arg 
    130                 135                 140                 


Lys Ser Arg Ala Pro Ala 
145                 150 


<210>  14
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of murine TREML4

<400>  14

Glu Glu Leu His Arg Met Val Gly Gln Ser Leu Ser Val Gln Cys Gln 
1               5                   10                  15      


Tyr Lys Pro Lys Glu Glu Ser Tyr Val Leu Lys Thr Trp Cys Arg Gln 
            20                  25                  30          


Thr Ala Pro Ser Lys Cys Thr Arg Val Val Thr Thr Ser Glu Pro Arg 
        35                  40                  45              


Lys Ala Ala Arg Glu Leu Gln His Thr Ile Trp Asp Asp Pro Glu Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Thr Met Thr Gln Leu Thr Glu Asp Asp Ser Ala 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Pro Tyr Tyr Pro Ser Leu Arg Glu Val Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Ser Thr Leu Pro 
            100                 105                 110         


Ser Gln Thr Ile Ala Pro Leu Pro Glu Ser Thr Ala Thr Ile Phe Met 
        115                 120                 125             


Pro Phe Pro Val Leu Thr Thr Ser Pro Glu Glu Thr Thr Asp Ser Ser 
    130                 135                 140                 


Ile Asn Gly Thr Gly His Arg Asn Gln Ser Ser Ser Ser Pro Gly Trp 
145                 150                 155                 160 


Thr Ser Pro Gly 
                


<210>  15
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of TREM2

<400>  15

His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu Gln Val 
1               5                   10                  15      


Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys Ala Trp 
            20                  25                  30          


Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val Ser Thr 
        35                  40                  45              


His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly Ser Thr 
    50                  55                  60                  


Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr Leu Arg 
65                  70                  75                  80  


Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser Leu His 
                85                  90                  95      


Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val Leu Ala 
            100                 105                 110         


Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro Gly Glu 
        115                 120                 125             


Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser Arg 
    130                 135                 140             


<210>  16
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of human TREM1

<400>  16

Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys Glu Gly Gln Thr 
1               5                   10                  15      


Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe Ala Ser Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro Lys Thr Leu Ala 
        35                  40                  45              


Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val Gln Val Gly Arg 
    50                  55                  60                  


Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu Arg Val Arg Met 
65                  70                  75                  80  


Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln Cys Val Ile Tyr 
                85                  90                  95      


Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg Ile Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn Glu Asn Ser Thr 
        115                 120                 125             


Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys Ala Leu Cys Pro 
    130                 135                 140                 


Leu Tyr Thr Ser Pro Arg Thr Val 
145                 150         


<210>  17
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of TREML1

<400>  17

Gln Gly Ile Val Gly Ser Leu Pro Glu Val Leu Gln Ala Pro Val Gly 
1               5                   10                  15      


Ser Ser Ile Leu Val Gln Cys His Tyr Arg Leu Gln Asp Val Lys Ala 
            20                  25                  30          


Gln Lys Val Trp Cys Arg Phe Leu Pro Glu Gly Cys Gln Pro Leu Val 
        35                  40                  45              


Ser Ser Ala Val Asp Arg Arg Ala Pro Ala Gly Arg Arg Thr Phe Leu 
    50                  55                  60                  


Thr Asp Leu Gly Gly Gly Leu Leu Gln Val Glu Met Val Thr Leu Gln 
65                  70                  75                  80  


Glu Glu Asp Ala Gly Glu Tyr Gly Cys Met Val Asp Gly Ala Arg Gly 
                85                  90                  95      


Pro Gln Ile Leu His Arg Val Ser Leu Asn Ile Leu Pro Pro Glu Glu 
            100                 105                 110         


Glu Glu Glu Thr His Lys Ile Gly Ser Leu Ala Glu Asn Ala Phe Ser 
        115                 120                 125             


Asp Pro Ala Gly Ser Ala Asn Pro Leu Glu Pro Ser Gln Asp Glu Lys 
    130                 135                 140                 


Ser Ile Pro 
145         


<210>  18
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ectodomain of TREML2

<400>  18

Pro Ser Ala Asp Ser Val Tyr Thr Lys Val Arg Leu Leu Glu Gly Glu 
1               5                   10                  15      


Thr Leu Ser Val Gln Cys Ser Tyr Lys Gly Tyr Lys Asn Arg Val Glu 
            20                  25                  30          


Gly Lys Val Trp Cys Lys Ile Arg Lys Lys Lys Cys Glu Pro Gly Phe 
        35                  40                  45              


Ala Arg Val Trp Val Lys Gly Pro Arg Tyr Leu Leu Gln Asp Asp Ala 
    50                  55                  60                  


Gln Ala Lys Val Val Asn Ile Thr Met Val Ala Leu Lys Leu Gln Asp 
65                  70                  75                  80  


Ser Gly Arg Tyr Trp Cys Met Arg Asn Thr Ser Gly Ile Leu Tyr Pro 
                85                  90                  95      


Leu Met Gly Phe Gln Leu Asp Val Ser Pro Ala Pro Gln Thr Glu Arg 
            100                 105                 110         


Asn Ile Pro Phe Thr His Leu Asp Asn Ile Leu Lys Ser Gly Thr Val 
        115                 120                 125             


Thr Thr Gly Gln Ala Pro Thr Ser Gly Pro Asp Ala Pro Phe Thr Thr 
    130                 135                 140                 


Gly Val Met Val Phe Thr Pro Gly Leu Ile Thr Leu Pro Arg Leu Leu 
145                 150                 155                 160 


Ala Ser Thr 
            


<210>  19
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc domain of wild-type human IgG1

<400>  19

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  20
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc domain of human IgG1 (N297Q mutation)

<400>  20

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  21
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc domain of human IgG1 (N297A mutation)

<400>  21

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  22
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc domain of human IgG1 (N297G mutation)

<400>  22

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker domain

<400>  23

Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10              


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker domain

<400>  24

Gly Gly Gly Gly Ser 
1               5   


<210>  25
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  25

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser 
            


<210>  26
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of hTREML4- linker- Fc domain of human 
       IgG1(glycosylation site N297Q mutation)

<400>  26

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu 
            20                  25                  30          


Gln Cys Gln Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp 
        35                  40                  45              


Cys Gln Gln Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser 
    50                  55                  60                  


Lys Pro Trp Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys 
65                  70                  75                  80  


Pro Asn Ala Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn 
                85                  90                  95      


Asp Ser Gly Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile 
            100                 105                 110         


Ile Thr Val Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr 
        115                 120                 125             


Thr Ser Pro Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu 
    130                 135                 140                 


Ile Thr Ser Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Arg Lys Ser Arg Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
            180                 185                 190         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210>  27
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of hTREML4-K86D- linker- Fc domain of human 
       IgG1(glycosylation site N297Q mutation)

<400>  27

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu 
            20                  25                  30          


Gln Cys Gln Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp 
        35                  40                  45              


Cys Gln Gln Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser 
    50                  55                  60                  


Lys Pro Trp Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Asp 
65                  70                  75                  80  


Pro Asn Ala Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn 
                85                  90                  95      


Asp Ser Gly Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile 
            100                 105                 110         


Ile Thr Val Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr 
        115                 120                 125             


Thr Ser Pro Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu 
    130                 135                 140                 


Ile Thr Ser Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Arg Lys Ser Arg Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
            180                 185                 190         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210>  28
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader- ectodomain of hTREML4-L65R- Linker- Fc domain of human 
       IgG1(glycosylation site N297Q mutation)

<400>  28

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu 
            20                  25                  30          


Gln Cys Gln Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp 
        35                  40                  45              


Cys Gln Gln Thr Ser Pro Ser Arg Cys Thr Arg Leu Val Thr Ser Ser 
    50                  55                  60                  


Lys Pro Trp Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys 
65                  70                  75                  80  


Pro Asn Ala Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn 
                85                  90                  95      


Asp Ser Gly Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile 
            100                 105                 110         


Ile Thr Val Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr 
        115                 120                 125             


Thr Ser Pro Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu 
    130                 135                 140                 


Ile Thr Ser Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Arg Lys Ser Arg Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
            180                 185                 190         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210>  29
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader- ectodomain of hTREML4-K71E- Linker- Fc domain of human 
       IgG1(glycosylation site N297Q mutation)

<400>  29

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu 
            20                  25                  30          


Gln Cys Gln Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp 
        35                  40                  45              


Cys Gln Gln Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser 
    50                  55                  60                  


Glu Pro Trp Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys 
65                  70                  75                  80  


Pro Asn Ala Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn 
                85                  90                  95      


Asp Ser Gly Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile 
            100                 105                 110         


Ile Thr Val Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr 
        115                 120                 125             


Thr Ser Pro Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu 
    130                 135                 140                 


Ile Thr Ser Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Arg Lys Ser Arg Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
            180                 185                 190         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210>  30
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of hTREML4-T95K- Linker- Fc domain of human 
       IgG1(glycosylation site N297Q mutation)

<400>  30

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu 
            20                  25                  30          


Gln Cys Gln Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp 
        35                  40                  45              


Cys Gln Gln Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser 
    50                  55                  60                  


Lys Pro Trp Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys 
65                  70                  75                  80  


Pro Asn Ala Gly Phe Phe Asn Ile Lys Met Ile Gln Leu Thr Gln Asn 
                85                  90                  95      


Asp Ser Gly Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile 
            100                 105                 110         


Ile Thr Val Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr 
        115                 120                 125             


Thr Ser Pro Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu 
    130                 135                 140                 


Ile Thr Ser Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Arg Lys Ser Arg Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
            180                 185                 190         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210>  31
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of hTREML4-T35S- Linker- Fc domain of human 
       IgG1(glycosylation site N297Q mutation)

<400>  31

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Glu Leu His Lys His Pro Gly Gln Ser Leu Leu Leu 
            20                  25                  30          


Gln Cys Gln Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp 
        35                  40                  45              


Cys Gln Gln Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser 
    50                  55                  60                  


Lys Pro Trp Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys 
65                  70                  75                  80  


Pro Asn Ala Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn 
                85                  90                  95      


Asp Ser Gly Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile 
            100                 105                 110         


Ile Thr Val Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr 
        115                 120                 125             


Thr Ser Pro Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu 
    130                 135                 140                 


Ile Thr Ser Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Arg Lys Ser Arg Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
            180                 185                 190         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210>  32
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of hTREML4-L66V- Linker- Fc domain of human 
       IgG1(glycosylation site N297Q mutation)

<400>  32

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu 
            20                  25                  30          


Gln Cys Gln Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp 
        35                  40                  45              


Cys Gln Gln Thr Ser Pro Ser Arg Cys Thr Leu Val Val Thr Ser Ser 
    50                  55                  60                  


Lys Pro Trp Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys 
65                  70                  75                  80  


Pro Asn Ala Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn 
                85                  90                  95      


Asp Ser Gly Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile 
            100                 105                 110         


Ile Thr Val Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr 
        115                 120                 125             


Thr Ser Pro Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu 
    130                 135                 140                 


Ile Thr Ser Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Arg Lys Ser Arg Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
            180                 185                 190         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210>  33
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of hTREML4-S69T- Linker- Fc domain of human 
       IgG1(glycosylation site N297Q mutation)

<400>  33

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu 
            20                  25                  30          


Gln Cys Gln Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp 
        35                  40                  45              


Cys Gln Gln Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Thr Ser 
    50                  55                  60                  


Lys Pro Trp Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys 
65                  70                  75                  80  


Pro Asn Ala Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn 
                85                  90                  95      


Asp Ser Gly Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile 
            100                 105                 110         


Ile Thr Val Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr 
        115                 120                 125             


Thr Ser Pro Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu 
    130                 135                 140                 


Ile Thr Ser Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Arg Lys Ser Arg Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
            180                 185                 190         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210>  34
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of hTREML4-K78E- Linker- Fc domain of human 
       IgG1(glycosylation site N297Q mutation)

<400>  34

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu 
            20                  25                  30          


Gln Cys Gln Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp 
        35                  40                  45              


Cys Gln Gln Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser 
    50                  55                  60                  


Lys Pro Trp Thr Ala Val Gln Glu Ser His Tyr Thr Ile Trp Asp Lys 
65                  70                  75                  80  


Pro Asn Ala Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn 
                85                  90                  95      


Asp Ser Gly Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile 
            100                 105                 110         


Ile Thr Val Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr 
        115                 120                 125             


Thr Ser Pro Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu 
    130                 135                 140                 


Ile Thr Ser Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Arg Lys Ser Arg Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
            180                 185                 190         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210>  35
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of hTREML4-G156E- Linker- Fc domain of human 
       IgG1(glycosylation site N297Q mutation)

<400>  35

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu 
            20                  25                  30          


Gln Cys Gln Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp 
        35                  40                  45              


Cys Gln Gln Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser 
    50                  55                  60                  


Lys Pro Trp Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys 
65                  70                  75                  80  


Pro Asn Ala Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn 
                85                  90                  95      


Asp Ser Gly Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile 
            100                 105                 110         


Ile Thr Val Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr 
        115                 120                 125             


Thr Ser Pro Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu 
    130                 135                 140                 


Ile Thr Ser Pro Glu Glu Thr Ser Gly His Pro Ser Ile Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Arg Lys Ser Arg Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
            180                 185                 190         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210>  36
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of hTREML4-H160D- Linker- Fc domain of human 
       IgG1(glycosylation site N297Q mutation)

<400>  36

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu 
            20                  25                  30          


Gln Cys Gln Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp 
        35                  40                  45              


Cys Gln Gln Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser 
    50                  55                  60                  


Lys Pro Trp Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys 
65                  70                  75                  80  


Pro Asn Ala Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn 
                85                  90                  95      


Asp Ser Gly Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile 
            100                 105                 110         


Ile Thr Val Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr 
        115                 120                 125             


Thr Ser Pro Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu 
    130                 135                 140                 


Ile Thr Ser Pro Glu Gly Thr Ser Gly Asp Pro Ser Ile Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Arg Lys Ser Arg Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
            180                 185                 190         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210>  37
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of hTREML4-L65R/K71E/K86D- Linker- Fc domain 
       of human IgG1(a glycosylation site N297Q mutation)

<400>  37

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu 
            20                  25                  30          


Gln Cys Gln Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp 
        35                  40                  45              


Cys Gln Gln Thr Ser Pro Ser Arg Cys Thr Arg Leu Val Thr Ser Ser 
    50                  55                  60                  


Glu Pro Trp Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Asp 
65                  70                  75                  80  


Pro Asn Ala Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn 
                85                  90                  95      


Asp Ser Gly Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile 
            100                 105                 110         


Ile Thr Val Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr 
        115                 120                 125             


Thr Ser Pro Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu 
    130                 135                 140                 


Ile Thr Ser Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Arg Lys Ser Arg Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
            180                 185                 190         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210>  38
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of hTREML4-L65R/K71E/K86D/T95K- Linker- Fc 
       domain of human IgG1(a glycosylation site N297Q mutation)

<400>  38

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu 
            20                  25                  30          


Gln Cys Gln Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp 
        35                  40                  45              


Cys Gln Gln Thr Ser Pro Ser Arg Cys Thr Arg Leu Val Thr Ser Ser 
    50                  55                  60                  


Glu Pro Trp Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Asp 
65                  70                  75                  80  


Pro Asn Ala Gly Phe Phe Asn Ile Lys Met Ile Gln Leu Thr Gln Asn 
                85                  90                  95      


Asp Ser Gly Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile 
            100                 105                 110         


Ile Thr Val Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr 
        115                 120                 125             


Thr Ser Pro Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu 
    130                 135                 140                 


Ile Thr Ser Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Arg Lys Ser Arg Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
            180                 185                 190         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210>  39
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of murine TREML4 - Linker- Fc domain of human 
       IgG1(a glycosylation site N297Q mutation)

<400>  39

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Glu Leu His Arg Met Val Gly Gln Ser Leu Ser Val 
            20                  25                  30          


Gln Cys Gln Tyr Lys Pro Lys Glu Glu Ser Tyr Val Leu Lys Thr Trp 
        35                  40                  45              


Cys Arg Gln Thr Ala Pro Ser Lys Cys Thr Arg Val Val Thr Thr Ser 
    50                  55                  60                  


Glu Pro Arg Lys Ala Ala Arg Glu Leu Gln His Thr Ile Trp Asp Asp 
65                  70                  75                  80  


Pro Glu Ala Gly Phe Phe Asn Ile Thr Met Thr Gln Leu Thr Glu Asp 
                85                  90                  95      


Asp Ser Ala Phe Tyr Trp Cys Gly Pro Tyr Tyr Pro Ser Leu Arg Glu 
            100                 105                 110         


Val Thr Val Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Ser 
        115                 120                 125             


Thr Leu Pro Ser Gln Thr Ile Ala Pro Leu Pro Glu Ser Thr Ala Thr 
    130                 135                 140                 


Ile Phe Met Pro Phe Pro Val Leu Thr Thr Ser Pro Glu Glu Thr Thr 
145                 150                 155                 160 


Asp Ser Ser Ile Asn Gly Thr Gly His Arg Asn Gln Ser Ser Ser Ser 
                165                 170                 175     


Pro Gly Trp Thr Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        195                 200                 205             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    210                 215                 220                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
225                 230                 235                 240 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                245                 250                 255     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            260                 265                 270         


Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        275                 280                 285             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    290                 295                 300                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
305                 310                 315                 320 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                325                 330                 335     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            340                 345                 350         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        355                 360                 365             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    370                 375                 380                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
385                 390                 395                 400 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                405                 410                 415     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425 


<210>  40
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of human TREM2- Linker- Fc domain of human 
       IgG1(a glycosylation site N297Q mutation)

<400>  40

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser 
            20                  25                  30          


Leu Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg 
        35                  40                  45              


Lys Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val 
    50                  55                  60                  


Val Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn 
65                  70                  75                  80  


Gly Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile 
                85                  90                  95      


Thr Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln 
            100                 105                 110         


Ser Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu 
        115                 120                 125             


Val Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe 
    130                 135                 140                 


Pro Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile 
145                 150                 155                 160 


Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            180                 185                 190         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        195                 200                 205             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    210                 215                 220                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
225                 230                 235                 240 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr 
                245                 250                 255     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            260                 265                 270         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        275                 280                 285             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    290                 295                 300                 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
305                 310                 315                 320 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                325                 330                 335     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            340                 345                 350         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        355                 360                 365             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    370                 375                 380                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
385                 390                 395                 400 


Ser Pro Gly Lys 
                


<210>  41
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of human TREM1- Linker- Fc domain of human 
       IgG1(a glycosylation site N297Q mutation)

<400>  41

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys Glu 
            20                  25                  30          


Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe Ala 
        35                  40                  45              


Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro Lys 
    50                  55                  60                  


Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val Gln 
65                  70                  75                  80  


Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu Arg 
                85                  90                  95      


Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln Cys 
            100                 105                 110         


Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg Ile 
        115                 120                 125             


Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn Glu 
    130                 135                 140                 


Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys Ala 
145                 150                 155                 160 


Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys 
            180                 185                 190         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        195                 200                 205             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    210                 215                 220                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
225                 230                 235                 240 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                245                 250                 255     


Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu 
            260                 265                 270         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        275                 280                 285             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    290                 295                 300                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
305                 310                 315                 320 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                325                 330                 335     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            340                 345                 350         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        355                 360                 365             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    370                 375                 380                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
385                 390                 395                 400 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410             


<210>  42
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of human TREML1- Linker- Fc domain of human 
       IgG1(a glycosylation site N297Q mutation)

<400>  42

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Gln Gly Ile Val Gly Ser Leu Pro Glu Val Leu Gln Ala 
            20                  25                  30          


Pro Val Gly Ser Ser Ile Leu Val Gln Cys His Tyr Arg Leu Gln Asp 
        35                  40                  45              


Val Lys Ala Gln Lys Val Trp Cys Arg Phe Leu Pro Glu Gly Cys Gln 
    50                  55                  60                  


Pro Leu Val Ser Ser Ala Val Asp Arg Arg Ala Pro Ala Gly Arg Arg 
65                  70                  75                  80  


Thr Phe Leu Thr Asp Leu Gly Gly Gly Leu Leu Gln Val Glu Met Val 
                85                  90                  95      


Thr Leu Gln Glu Glu Asp Ala Gly Glu Tyr Gly Cys Met Val Asp Gly 
            100                 105                 110         


Ala Arg Gly Pro Gln Ile Leu His Arg Val Ser Leu Asn Ile Leu Pro 
        115                 120                 125             


Pro Glu Glu Glu Glu Glu Thr His Lys Ile Gly Ser Leu Ala Glu Asn 
    130                 135                 140                 


Ala Phe Ser Asp Pro Ala Gly Ser Ala Asn Pro Leu Glu Pro Ser Gln 
145                 150                 155                 160 


Asp Glu Lys Ser Ile Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            180                 185                 190         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        195                 200                 205             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    210                 215                 220                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
225                 230                 235                 240 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                245                 250                 255     


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            260                 265                 270         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        275                 280                 285             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    290                 295                 300                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
305                 310                 315                 320 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                325                 330                 335     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            340                 345                 350         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        355                 360                 365             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    370                 375                 380                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
385                 390                 395                 400 


Ser Leu Ser Leu Ser Pro Gly Lys 
                405             


<210>  43
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader- ectodomain of human TREML2- Linker- Fc domain of human 
       IgG1(a glycosylation site N297Q mutation)

<400>  43

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Pro Ser Ala Asp Ser Val Tyr Thr Lys Val Arg Leu Leu 
            20                  25                  30          


Glu Gly Glu Thr Leu Ser Val Gln Cys Ser Tyr Lys Gly Tyr Lys Asn 
        35                  40                  45              


Arg Val Glu Gly Lys Val Trp Cys Lys Ile Arg Lys Lys Lys Cys Glu 
    50                  55                  60                  


Pro Gly Phe Ala Arg Val Trp Val Lys Gly Pro Arg Tyr Leu Leu Gln 
65                  70                  75                  80  


Asp Asp Ala Gln Ala Lys Val Val Asn Ile Thr Met Val Ala Leu Lys 
                85                  90                  95      


Leu Gln Asp Ser Gly Arg Tyr Trp Cys Met Arg Asn Thr Ser Gly Ile 
            100                 105                 110         


Leu Tyr Pro Leu Met Gly Phe Gln Leu Asp Val Ser Pro Ala Pro Gln 
        115                 120                 125             


Thr Glu Arg Asn Ile Pro Phe Thr His Leu Asp Asn Ile Leu Lys Ser 
    130                 135                 140                 


Gly Thr Val Thr Thr Gly Gln Ala Pro Thr Ser Gly Pro Asp Ala Pro 
145                 150                 155                 160 


Phe Thr Thr Gly Val Met Val Phe Thr Pro Gly Leu Ile Thr Leu Pro 
                165                 170                 175     


Arg Leu Leu Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            180                 185                 190         


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        195                 200                 205             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    210                 215                 220                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
225                 230                 235                 240 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                245                 250                 255     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            260                 265                 270         


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        275                 280                 285             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    290                 295                 300                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
305                 310                 315                 320 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                325                 330                 335     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            340                 345                 350         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        355                 360                 365             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    370                 375                 380                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
385                 390                 395                 400 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                405                 410                 415     


Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 


<210>  44
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length wild-type human TREML4

<400>  44

Met Ala Trp Gly Gly Val His Thr Cys Cys Phe His Leu Cys Cys Cys 
1               5                   10                  15      


Cys Ser Trp Pro Gln Gly Ala Val Pro Glu Glu Leu His Lys His Pro 
            20                  25                  30          


Gly Gln Thr Leu Leu Leu Gln Cys Gln Tyr Ser Pro Lys Arg Gly Pro 
        35                  40                  45              


Tyr Gln Pro Lys Ser Trp Cys Gln Gln Thr Ser Pro Ser Arg Cys Thr 
    50                  55                  60                  


Leu Leu Val Thr Ser Ser Lys Pro Trp Thr Ala Val Gln Lys Ser His 
65                  70                  75                  80  


Tyr Thr Ile Trp Asp Lys Pro Asn Ala Gly Phe Phe Asn Ile Thr Met 
                85                  90                  95      


Ile Gln Leu Thr Gln Asn Asp Ser Gly Phe Tyr Trp Cys Gly Ile Tyr 
            100                 105                 110         


Asn Ala Ser Glu Asn Ile Ile Thr Val Leu Arg Asn Ile Ser Leu Val 
        115                 120                 125             


Val Ser Pro Ala Pro Thr Thr Ser Pro Met Trp Thr Leu Pro Trp Leu 
    130                 135                 140                 


Pro Thr Ser Thr Val Leu Ile Thr Ser Pro Glu Gly Thr Ser Gly His 
145                 150                 155                 160 


Pro Ser Ile Asn Gly Ser Glu Thr Arg Lys Ser Arg Ala Pro Ala Cys 
                165                 170                 175     


Leu Gly Ser Gly Gly Pro Arg Phe Leu Val Leu Val Leu Cys Gly Leu 
            180                 185                 190         


Leu Leu Ala Lys Gly Leu Met Leu 
        195                 200 


<210>  45
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTREM2

<400>  45

His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu Gln Val 
1               5                   10                  15      


Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys Ala Trp 
            20                  25                  30          


Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val Ser Thr 
        35                  40                  45              


His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly Ser Thr 
    50                  55                  60                  


Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr Leu Arg 
65                  70                  75                  80  


Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser Leu His 
                85                  90                  95      


Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val Leu Ala 
            100                 105                 110         


Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro Gly Glu 
        115                 120                 125             


Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser Arg 
    130                 135                 140             


<210>  46
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mTREML4

<400>  46

Glu Glu Leu His Arg Met Val Gly Gln Ser Leu Ser Val Gln Cys Gln 
1               5                   10                  15      


Tyr Lys Pro Lys Glu Glu Ser Tyr Val Leu Lys Thr Trp Cys Arg Gln 
            20                  25                  30          


Thr Ala Pro Ser Lys Cys Thr Arg Val Val Thr Thr Ser Glu Pro Arg 
        35                  40                  45              


Lys Ala Ala Arg Glu Leu Gln His Thr Ile Trp Asp Asp Pro Glu Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Thr Met Thr Gln Leu Thr Glu Asp Asp Ser Ala 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Pro Tyr Tyr Pro Ser Leu Arg Glu Val Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Ser Thr Leu Pro 
            100                 105                 110         


Ser Gln Thr Ile Ala Pro Leu Pro Glu Ser Thr Ala Thr Ile Phe Met 
        115                 120                 125             


Pro Phe Pro Val Leu Thr Thr Ser Pro Glu Glu Thr Thr Asp Ser Ser 
    130                 135                 140                 


Ile Asn Gly Thr Gly His Arg Asn Gln Ser Ser Ser Ser Pro Gly Trp 
145                 150                 155                 160 


Thr Ser Pro Gly 
                


<210>  47
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTREML4

<400>  47

Glu Glu Leu His Lys His Pro Gly Gln Thr Leu Leu Leu Gln Cys Gln 
1               5                   10                  15      


Tyr Ser Pro Lys Arg Gly Pro Tyr Gln Pro Lys Ser Trp Cys Gln Gln 
            20                  25                  30          


Thr Ser Pro Ser Arg Cys Thr Leu Leu Val Thr Ser Ser Lys Pro Trp 
        35                  40                  45              


Thr Ala Val Gln Lys Ser His Tyr Thr Ile Trp Asp Lys Pro Asn Ala 
    50                  55                  60                  


Gly Phe Phe Asn Ile Thr Met Ile Gln Leu Thr Gln Asn Asp Ser Gly 
65                  70                  75                  80  


Phe Tyr Trp Cys Gly Ile Tyr Asn Ala Ser Glu Asn Ile Ile Thr Val 
                85                  90                  95      


Leu Arg Asn Ile Ser Leu Val Val Ser Pro Ala Pro Thr Thr Ser Pro 
            100                 105                 110         


Met Trp Thr Leu Pro Trp Leu Pro Thr Ser Thr Val Leu Ile Thr Ser 
        115                 120                 125             


Pro Glu Gly Thr Ser Gly His Pro Ser Ile Asn Gly Ser Glu Thr Arg 
    130                 135                 140                 


Lys Ser Arg Ala Pro Ala 
145                 150 


