                         SEQUENCE LISTING

<110>  Lygos, Inc.
 
<120>  Recombinant Host Cells and Methods for the Production of Glyceric
        Acid and Downstream Products

<130>  LYGOS-0014-01-US

<150>  62/6322237
<151>  2018-02-19

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  252
<212>  PRT
<213>  Escherichia coli

<400>  1

Met Asn Lys Phe Glu Asp Ile Arg Gly Val Ala Phe Asp Leu Asp Gly 
1               5                   10                  15      


Thr Leu Val Asp Ser Ala Pro Gly Leu Ala Ala Ala Val Asp Met Ala 
            20                  25                  30          


Leu Tyr Ala Leu Glu Leu Pro Val Ala Gly Glu Glu Arg Val Ile Thr 
        35                  40                  45              


Trp Ile Gly Asn Gly Ala Asp Val Leu Met Glu Arg Ala Leu Thr Trp 
    50                  55                  60                  


Ala Arg Gln Glu Arg Ala Thr Gln Arg Lys Thr Met Gly Lys Pro Pro 
65                  70                  75                  80  


Val Asp Asp Asp Ile Pro Ala Glu Glu Gln Val Arg Ile Leu Arg Lys 
                85                  90                  95      


Leu Phe Asp Arg Tyr Tyr Gly Glu Val Ala Glu Glu Gly Thr Phe Leu 
            100                 105                 110         


Phe Pro His Val Ala Asp Thr Leu Gly Ala Leu Gln Ala Lys Gly Leu 
        115                 120                 125             


Pro Leu Gly Leu Val Thr Asn Lys Pro Thr Pro Phe Val Ala Pro Leu 
    130                 135                 140                 


Leu Glu Ala Leu Asp Ile Ala Lys Tyr Phe Ser Val Val Ile Gly Gly 
145                 150                 155                 160 


Asp Asp Val Gln Asn Lys Lys Pro His Pro Asp Pro Leu Leu Leu Val 
                165                 170                 175     


Ala Glu Arg Met Gly Ile Ala Pro Gln Gln Met Leu Phe Val Gly Asp 
            180                 185                 190         


Ser Arg Asn Asp Ile Gln Ala Ala Lys Ala Ala Gly Cys Pro Ser Val 
        195                 200                 205             


Gly Leu Thr Tyr Gly Tyr Asn Tyr Gly Glu Ala Ile Asp Leu Ser Gln 
    210                 215                 220                 


Pro Asp Val Ile Tyr Gln Ser Ile Asn Asp Leu Leu Pro Ala Leu Gly 
225                 230                 235                 240 


Leu Pro His Ser Glu Asn Gln Glu Ser Lys Asn Asp 
                245                 250         


<210>  2
<211>  411
<212>  PRT
<213>  Mycobacterium avium

<400>  2

Met Asn Ser Pro Pro Lys Val Ser Val Leu Ile Thr Val Thr Gly Val 
1               5                   10                  15      


Asp Gln Pro Gly Val Thr Ala Thr Leu Phe Glu Val Leu Ser Gly His 
            20                  25                  30          


Gly Val Glu Leu Leu Asn Val Glu Gln Val Val Ile Arg His Arg Leu 
        35                  40                  45              


Thr Leu Gly Val Leu Val Cys Cys Pro Ala Asp Val Ala Asp Gly Pro 
    50                  55                  60                  


Ala Leu Arg His Asp Val Glu Ala Ala Ile Arg Lys Val Gly Leu Asp 
65                  70                  75                  80  


Val Ser Ile Glu Arg Ser Asp Asp Val Pro Ile Ile Arg Glu Pro Ser 
                85                  90                  95      


Thr His Thr Ile Phe Val Leu Gly Arg Pro Ile Thr Ala Ala Ala Phe 
            100                 105                 110         


Gly Ala Val Ala Arg Glu Val Ala Ala Leu Gly Val Asn Ile Asp Leu 
        115                 120                 125             


Ile Arg Gly Val Ser Asp Tyr Pro Val Ile Gly Leu Glu Leu Arg Val 
    130                 135                 140                 


Ser Val Pro Pro Gly Ala Asp Gly Ala Leu Arg Thr Ala Leu Asn Arg 
145                 150                 155                 160 


Val Ser Ser Glu Glu His Val Asp Val Ala Val Glu Asp Tyr Thr Leu 
                165                 170                 175     


Glu Arg Arg Ala Lys Arg Leu Ile Val Phe Asp Val Asp Ser Thr Leu 
            180                 185                 190         


Val Gln Gly Glu Val Ile Glu Met Leu Ala Ala Lys Ala Gly Ala Glu 
        195                 200                 205             


Gly Gln Val Ala Ala Ile Thr Asp Ala Ala Met Arg Gly Glu Leu Asp 
    210                 215                 220                 


Phe Ala Gln Ser Leu Gln Gln Arg Val Ala Thr Leu Ala Gly Leu Pro 
225                 230                 235                 240 


Ala Thr Val Ile Asp Glu Val Ala Gly Gln Leu Glu Leu Met Pro Gly 
                245                 250                 255     


Ala Arg Thr Thr Leu Arg Thr Leu Arg Arg Leu Gly Tyr Ala Cys Gly 
            260                 265                 270         


Val Val Ser Gly Gly Phe Arg Arg Ile Ile Glu Pro Leu Ala Glu Glu 
        275                 280                 285             


Leu Met Leu Asp Tyr Val Ala Ala Asn Glu Leu Glu Ile Val Asp Gly 
    290                 295                 300                 


Thr Leu Thr Gly Arg Val Val Gly Pro Ile Ile Asp Arg Ala Gly Lys 
305                 310                 315                 320 


Ala Thr Ala Leu Arg Glu Phe Ala Gln Arg Ala Gly Val Pro Met Ala 
                325                 330                 335     


Gln Thr Val Ala Val Gly Asp Gly Ala Asn Asp Ile Asp Met Leu Ala 
            340                 345                 350         


Ala Ala Gly Leu Gly Ile Ala Phe Asn Ala Lys Pro Ala Leu Arg Glu 
        355                 360                 365             


Val Ala Asp Ala Ser Leu Ser His Pro Tyr Leu Asp Thr Val Leu Phe 
    370                 375                 380                 


Leu Leu Gly Val Thr Arg Gly Glu Ile Glu Ala Ala Asp Ala Ile Asp 
385                 390                 395                 400 


Gly Glu Val Arg Arg Val Glu Ile Pro Pro Glu 
                405                 410     


<210>  3
<211>  224
<212>  PRT
<213>  Haemophilus somnus

<400>  3

Met Thr Gln Phe Lys Leu Ile Gly Phe Asp Leu Asp Gly Thr Leu Val 
1               5                   10                  15      


Asn Ser Leu Pro Asp Leu Ala Leu Ser Ile Asn Ser Ala Leu Lys Asp 
            20                  25                  30          


Val Asn Leu Pro Gln Ala Ser Glu Asn Leu Val Met Thr Trp Ile Gly 
        35                  40                  45              


Asn Gly Ala Asp Val Leu Ser Gln Arg Ala Val Asp Trp Ala Cys Lys 
    50                  55                  60                  


Gln Ala Glu Lys Glu Leu Thr Glu Asp Glu Phe Lys Tyr Phe Lys Arg 
65                  70                  75                  80  


Gln Phe Gly Phe Tyr Tyr Gly Glu Asn Leu Cys Asn Ile Ser Arg Leu 
                85                  90                  95      


Tyr Pro Asn Val Lys Glu Thr Leu Glu Ala Leu Lys Ala Gln Gly Tyr 
            100                 105                 110         


Ile Leu Ala Val Val Thr Asn Lys Pro Thr Lys His Val Gln Pro Ile 
        115                 120                 125             


Leu Thr Ala Phe Gly Ile Asp His Leu Phe Ser Glu Met Leu Gly Gly 
    130                 135                 140                 


Gln Ser Leu Pro Glu Ile Lys Pro His Pro Ala Pro Phe Tyr Tyr Leu 
145                 150                 155                 160 


Cys Gly Lys Phe Gly Leu Tyr Pro Lys Gln Ile Leu Phe Val Gly Asp 
                165                 170                 175     


Ser Gln Asn Asp Ile Phe Ala Ala His Ser Ala Gly Cys Ala Val Val 
            180                 185                 190         


Gly Leu Thr Tyr Gly Tyr Asn Tyr Asn Ile Pro Ile Ala Gln Ser Lys 
        195                 200                 205             


Pro Asp Trp Ile Phe Asp Asp Phe Ala Asp Ile Leu Lys Ile Thr Gln 
    210                 215                 220                 


<210>  4
<211>  250
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  4

Met Gly Leu Thr Thr Lys Pro Leu Ser Leu Lys Val Asn Ala Ala Leu 
1               5                   10                  15      


Phe Asp Val Asp Gly Thr Ile Ile Ile Ser Gln Pro Ala Ile Ala Ala 
            20                  25                  30          


Phe Trp Arg Asp Phe Gly Lys Asp Lys Pro Tyr Phe Asp Ala Glu His 
        35                  40                  45              


Val Ile Gln Val Ser His Gly Trp Arg Thr Phe Asp Ala Ile Ala Lys 
    50                  55                  60                  


Phe Ala Pro Asp Phe Ala Asn Glu Glu Tyr Val Asn Lys Leu Glu Ala 
65                  70                  75                  80  


Glu Ile Pro Val Lys Tyr Gly Glu Lys Ser Ile Glu Val Pro Gly Ala 
                85                  90                  95      


Val Lys Leu Cys Asn Ala Leu Asn Ala Leu Pro Lys Glu Lys Trp Ala 
            100                 105                 110         


Val Ala Thr Ser Gly Thr Arg Asp Met Ala Gln Lys Trp Phe Glu His 
        115                 120                 125             


Leu Gly Ile Arg Arg Pro Lys Tyr Phe Ile Thr Ala Asn Asp Val Lys 
    130                 135                 140                 


Gln Gly Lys Pro His Pro Glu Pro Tyr Leu Lys Gly Arg Asn Gly Leu 
145                 150                 155                 160 


Gly Tyr Pro Ile Asn Glu Gln Asp Pro Ser Lys Ser Lys Val Val Val 
                165                 170                 175     


Phe Glu Asp Ala Pro Ala Gly Ile Ala Ala Gly Lys Ala Ala Gly Cys 
            180                 185                 190         


Lys Ile Ile Gly Ile Ala Thr Thr Phe Asp Leu Asp Phe Leu Lys Glu 
        195                 200                 205             


Lys Gly Cys Asp Ile Ile Val Lys Asn His Glu Ser Ile Arg Val Gly 
    210                 215                 220                 


Gly Tyr Asn Ala Glu Thr Asp Glu Val Glu Phe Ile Phe Asp Asp Tyr 
225                 230                 235                 240 


Leu Tyr Ala Lys Asp Asp Leu Leu Lys Trp 
                245                 250 


<210>  5
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ala Ala Glu Ala Gly Gly Asp Asp Ala Arg Cys Val Arg Leu 
1               5                   10                  15      


Ser Ala Glu Arg Ala Gln Ala Leu Leu Ala Asp Val Asp Thr Leu Leu 
            20                  25                  30          


Phe Asp Cys Asp Gly Val Leu Trp Arg Gly Glu Thr Ala Val Pro Gly 
        35                  40                  45              


Ala Pro Glu Ala Leu Arg Ala Leu Arg Ala Arg Gly Lys Arg Leu Gly 
    50                  55                  60                  


Phe Ile Thr Asn Asn Ser Ser Lys Thr Arg Ala Ala Tyr Ala Glu Lys 
65                  70                  75                  80  


Leu Arg Arg Leu Gly Phe Gly Gly Pro Ala Gly Pro Gly Ala Ser Leu 
                85                  90                  95      


Glu Val Phe Gly Thr Ala Tyr Cys Thr Ala Leu Tyr Leu Arg Gln Arg 
            100                 105                 110         


Leu Ala Gly Ala Pro Ala Pro Lys Ala Tyr Val Leu Gly Ser Pro Ala 
        115                 120                 125             


Leu Ala Ala Glu Leu Glu Ala Val Gly Val Ala Ser Val Gly Val Gly 
    130                 135                 140                 


Pro Glu Pro Leu Gln Gly Glu Gly Pro Gly Asp Trp Leu His Ala Pro 
145                 150                 155                 160 


Leu Glu Pro Asp Val Arg Ala Val Val Val Gly Phe Asp Pro His Phe 
                165                 170                 175     


Ser Tyr Met Lys Leu Thr Lys Ala Leu Arg Tyr Leu Gln Gln Pro Gly 
            180                 185                 190         


Cys Leu Leu Val Gly Thr Asn Met Asp Asn Arg Leu Pro Leu Glu Asn 
        195                 200                 205             


Gly Arg Phe Ile Ala Gly Thr Gly Cys Leu Val Arg Ala Val Glu Met 
    210                 215                 220                 


Ala Ala Gln Arg Gln Ala Asp Ile Ile Gly Lys Pro Ser Arg Phe Ile 
225                 230                 235                 240 


Phe Asp Cys Val Ser Gln Glu Tyr Gly Ile Asn Pro Glu Arg Thr Val 
                245                 250                 255     


Met Val Gly Asp Arg Leu Asp Thr Asp Ile Leu Leu Gly Ala Thr Cys 
            260                 265                 270         


Gly Leu Lys Thr Ile Leu Thr Leu Thr Gly Val Ser Thr Leu Gly Asp 
        275                 280                 285             


Val Lys Asn Asn Gln Glu Ser Asp Cys Val Ser Lys Lys Lys Met Val 
    290                 295                 300                 


Pro Asp Phe Tyr Val Asp Ser Ile Ala Asp Leu Leu Pro Ala Leu Gln 
305                 310                 315                 320 


Gly 
    


<210>  6
<211>  550
<212>  PRT
<213>  Synechococcus elongatus

<400>  6

Met Lys Ile Lys Leu Leu Cys Ile Ser Leu Ala Val Leu Phe Cys Ser 
1               5                   10                  15      


Ser Ala Asn Ala Gln Lys Lys Gln Ala Lys Val Gln Pro Ser Val Phe 
            20                  25                  30          


Pro Gln Thr Val Ala Arg Pro Lys Leu Val Val Gly Met Val Ile Asp 
        35                  40                  45              


Gln Met Arg Trp Asp Tyr Leu Tyr Arg Phe Tyr Ala Arg Tyr Gly Asn 
    50                  55                  60                  


Gly Gly Phe Lys Arg Leu Ile Asn Glu Gly Phe Ser Ala Glu Asn Thr 
65                  70                  75                  80  


Leu Ile Pro Tyr Thr Pro Thr Leu Thr Ala Cys Gly His Ser Ser Ile 
                85                  90                  95      


Tyr Thr Gly Ser Val Pro Ala Ile Asn Gly Ile Ile Gly Asn Asn Trp 
            100                 105                 110         


Phe Asp Pro Gln Leu Gly Arg Asp Val Tyr Cys Val Glu Asp Lys Ser 
        115                 120                 125             


Val Lys Thr Val Gly Ser Ser Ser Asn Glu Gly Leu Met Ser Pro Lys 
    130                 135                 140                 


Asn Leu Leu Val Thr Thr Val Thr Asp Glu Leu Arg Met Ala Thr Asn 
145                 150                 155                 160 


Phe Arg Ser Lys Val Ile Ser Val Ser Ile Lys Asp Arg Gly Ala Ile 
                165                 170                 175     


Leu Pro Gly Gly His Thr Ala Asn Gly Ala Tyr Trp Tyr Asp Asp Met 
            180                 185                 190         


Thr Gly Ser Phe Ile Ser Ser Thr His Tyr Met Gln Gln Leu Pro Thr 
        195                 200                 205             


Trp Val Asn Asp Phe Asn Ala Gln Arg Leu Pro Asn Lys Tyr Phe Glu 
    210                 215                 220                 


Gln Asp Trp Asn Thr Leu Tyr Pro Ile Glu Thr Tyr Thr Glu Ser Thr 
225                 230                 235                 240 


Ala Asp Ala Lys Pro Tyr Glu Arg Thr Phe Lys Gly Ala Lys Thr Ser 
                245                 250                 255     


Ser Phe Pro His Leu Phe Lys Gln Tyr Ala Asn Lys Asn Tyr Ser Met 
            260                 265                 270         


Met Ala Ser Met Pro Gln Gly Asn Ser Phe Thr Leu Glu Phe Ala Lys 
        275                 280                 285             


Ala Ala Ile Pro Ala Glu Lys Leu Gly Gln Thr Gly Asn Thr Asp Phe 
    290                 295                 300                 


Leu Ala Val Ser Leu Ser Ser Thr Asp Tyr Val Gly His Gln Phe Gly 
305                 310                 315                 320 


Pro Asn Ser Ile Glu Leu Glu Asp Thr Tyr Leu Arg Leu Asp Lys Asp 
                325                 330                 335     


Leu Glu Asp Phe Phe Asn Tyr Leu Asp Lys Thr Ile Gly Lys Gly Asn 
            340                 345                 350         


Tyr Leu Leu Phe Leu Thr Ala Asp His Gly Ala Thr His Val Pro Gly 
        355                 360                 365             


Phe Leu Arg Asn Lys Met Pro Gly Gly Arg Leu Leu Leu Lys Val Gln 
    370                 375                 380                 


Thr Asp Leu Asp Ser Leu Ile Phe Asn Glu Phe Lys Val Arg Cys Asn 
385                 390                 395                 400 


Phe Thr Ile Ile Asn Asn Gln Val Ile Phe Asp Thr Asp Ala Ile Lys 
                405                 410                 415     


Glu Ala Lys Ala Asp Tyr Ala Lys Ile Lys Gln Ser Thr Ile Asp Tyr 
            420                 425                 430         


Leu Val Lys Gln Asp Gly Val Leu Asn Ala Val Asp Ile Lys Asn Met 
        435                 440                 445             


Gly Ala Val Thr Ile Pro Gln Glu Ile Lys Asn Lys Ile Ile Asn Gly 
    450                 455                 460                 


Tyr Asn Ala Arg Arg Ser Gly Asp Val Tyr Ile Ile Leu Asp Ala Gly 
465                 470                 475                 480 


Trp Tyr Pro Thr Leu Thr Pro Gly Thr Gly His Ala Ala Trp Asn Pro 
                485                 490                 495     


Tyr Asp Ser His Ile Pro Ala Leu Phe Met Gly Trp Gly Val Lys Pro 
            500                 505                 510         


Gly Lys Thr Asn Lys Glu Tyr Tyr Met Ser Asp Ile Ala Pro Thr Val 
        515                 520                 525             


Ser Ala Leu Leu His Ile Gln Gln Pro Ser Gly Ser Ile Gly Lys Val 
    530                 535                 540                 


Ile Thr Asp Leu Leu Lys 
545                 550 


<210>  7
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  7

Met Met Thr Thr Thr Met Met Pro Ile Lys Ile Thr Thr Lys Glu Gln 
1               5                   10                  15      


Val Gln Glu Phe Leu Asp Lys Tyr Asp Thr Phe Leu Phe Asp Cys Asp 
            20                  25                  30          


Gly Val Leu Trp Leu Gly Asp His Leu Leu Pro Ser Val Lys Glu Thr 
        35                  40                  45              


Leu Asp Leu Leu Lys Ser Leu Gly Lys Gln Leu Ile Phe Val Thr Asn 
    50                  55                  60                  


Asn Ser Thr Lys Ser Arg Ala Ala Tyr Thr Lys Lys Phe Ala Lys Phe 
65                  70                  75                  80  


Gly Ile Thr Gly Val Thr Glu Asp Glu Ile Phe Gly Ser Ser Tyr Ala 
                85                  90                  95      


Ser Ala Val Tyr Val Arg Asp Phe Leu Lys Leu Pro Pro Gly Lys Asp 
            100                 105                 110         


Lys Val Trp Val Phe Gly Glu Ser Gly Ile Glu Glu Glu Leu Lys Glu 
        115                 120                 125             


Met Gly Tyr Glu Thr Leu Gly Gly Thr Asp Pro Arg Leu Asp Glu Pro 
    130                 135                 140                 


Gly Val Lys Phe Asp Ala Asp Thr Ser Pro Phe Leu Val Asn Gly Leu 
145                 150                 155                 160 


Asp Pro Asp Val Gly Cys Val Val Ala Gly Leu Asp Thr Lys Ile Asn 
                165                 170                 175     


Tyr His Arg Leu Ala Ile Thr Leu Gln Tyr Leu Gln Lys Asp Asn Pro 
            180                 185                 190         


Ser Val Pro Phe Val Ala Thr Asn Ile Asp Ser Thr Phe Pro Gln Lys 
        195                 200                 205             


Gly Lys Leu Leu Pro Gly Ala Gly Ser Ile Ile Glu Ser Val Ala Phe 
    210                 215                 220                 


Ala Ser Gly Arg Gln Pro Asp Ala Ala Cys Gly Lys Pro Asn Gln Asn 
225                 230                 235                 240 


Met Leu Asn Ser Ile Lys Ala Ala Lys Pro Gly Leu Asn Leu Asp Pro 
                245                 250                 255     


Ser Arg Cys Cys Met Val Gly Asp Arg Leu Asn Thr Asp Met Lys Phe 
            260                 265                 270         


Gly Arg Asp Gly Gly Leu Gly Gly Thr Leu Leu Val Leu Thr Gly Ile 
        275                 280                 285             


Glu Thr Glu Glu Arg Ala Leu Ala Leu Ser Asp Glu His Pro Ala Pro 
    290                 295                 300                 


Lys Tyr Tyr Ala Asp Lys Leu Gly Asp Leu Tyr Glu Leu Thr His Asn 
305                 310                 315                 320 


Asn 
    


<210>  8
<211>  266
<212>  PRT
<213>  Escherichia coli

<400>  8

Met Tyr Gln Val Val Ala Ser Asp Leu Asp Gly Thr Leu Leu Ser Pro 
1               5                   10                  15      


Asp His Thr Leu Ser Pro Tyr Ala Lys Glu Thr Leu Lys Leu Leu Thr 
            20                  25                  30          


Ala Arg Gly Ile Asn Phe Val Phe Ala Thr Gly Arg His His Val Asp 
        35                  40                  45              


Val Gly Gln Ile Arg Asp Asn Leu Glu Ile Lys Ser Tyr Met Ile Thr 
    50                  55                  60                  


Ser Asn Gly Ala Arg Val His Asp Leu Asp Gly Asn Leu Ile Phe Ala 
65                  70                  75                  80  


His Asn Leu Asp Arg Asp Ile Ala Ser Asp Leu Phe Gly Val Val Asn 
                85                  90                  95      


Asp Asn Pro Asp Ile Ile Thr Asn Val Tyr Arg Asp Asp Glu Trp Phe 
            100                 105                 110         


Met Asn Arg His Arg Pro Glu Glu Met Arg Phe Phe Lys Glu Ala Val 
        115                 120                 125             


Phe Gln Tyr Ala Leu Tyr Glu Pro Gly Leu Leu Glu Pro Glu Gly Val 
    130                 135                 140                 


Ser Lys Val Phe Phe Thr Cys Asp Ser His Glu Gln Leu Leu Pro Leu 
145                 150                 155                 160 


Glu Gln Ala Ile Asn Ala Arg Trp Gly Asp Arg Val Asn Val Ser Phe 
                165                 170                 175     


Ser Thr Leu Thr Cys Leu Glu Val Met Ala Gly Gly Val Ser Lys Gly 
            180                 185                 190         


His Ala Leu Glu Ala Val Ala Lys Lys Leu Gly Tyr Ser Leu Lys Asp 
        195                 200                 205             


Cys Ile Ala Phe Gly Asp Gly Met Asn Asp Ala Glu Met Leu Ser Met 
    210                 215                 220                 


Ala Gly Lys Gly Cys Ile Met Gly Ser Ala His Gln Arg Leu Lys Asp 
225                 230                 235                 240 


Leu His Pro Glu Leu Glu Val Ile Gly Thr Asn Ala Asp Asp Ala Val 
                245                 250                 255     


Pro His Tyr Leu Arg Lys Leu Tyr Leu Ser 
            260                 265     


<210>  9
<211>  312
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  9

Met Thr Ala Gln Gln Gly Val Pro Ile Lys Ile Thr Asn Lys Glu Ile 
1               5                   10                  15      


Ala Gln Glu Phe Leu Asp Lys Tyr Asp Thr Phe Leu Phe Asp Cys Asp 
            20                  25                  30          


Gly Val Leu Trp Leu Gly Ser Gln Ala Leu Pro Tyr Thr Leu Glu Ile 
        35                  40                  45              


Leu Asn Leu Leu Lys Gln Leu Gly Lys Gln Leu Ile Phe Val Thr Asn 
    50                  55                  60                  


Asn Ser Thr Lys Ser Arg Leu Ala Tyr Thr Lys Lys Phe Ala Ser Phe 
65                  70                  75                  80  


Gly Ile Asp Val Lys Glu Glu Gln Ile Phe Thr Ser Gly Tyr Ala Ser 
                85                  90                  95      


Ala Val Tyr Ile Arg Asp Phe Leu Lys Leu Gln Pro Gly Lys Asp Lys 
            100                 105                 110         


Val Trp Val Phe Gly Glu Ser Gly Ile Gly Glu Glu Leu Lys Leu Met 
        115                 120                 125             


Gly Tyr Glu Ser Leu Gly Gly Ala Asp Ser Arg Leu Asp Thr Pro Phe 
    130                 135                 140                 


Asp Ala Ala Lys Ser Pro Phe Leu Val Asn Gly Leu Asp Lys Asp Val 
145                 150                 155                 160 


Ser Cys Val Ile Ala Gly Leu Asp Thr Lys Val Asn Tyr His Arg Leu 
                165                 170                 175     


Ala Val Thr Leu Gln Tyr Leu Gln Lys Asp Ser Val His Phe Val Gly 
            180                 185                 190         


Thr Asn Val Asp Ser Thr Phe Pro Gln Lys Gly Tyr Thr Phe Pro Gly 
        195                 200                 205             


Ala Gly Ser Met Ile Glu Ser Leu Ala Phe Ser Ser Asn Arg Arg Pro 
    210                 215                 220                 


Ser Tyr Cys Gly Lys Pro Asn Gln Asn Met Leu Asn Ser Ile Ile Ser 
225                 230                 235                 240 


Ala Phe Asn Leu Asp Arg Ser Lys Cys Cys Met Val Gly Asp Arg Leu 
                245                 250                 255     


Asn Thr Asp Met Lys Phe Gly Val Glu Gly Gly Leu Gly Gly Thr Leu 
            260                 265                 270         


Leu Val Leu Ser Gly Ile Glu Thr Glu Glu Arg Ala Leu Lys Ile Ser 
        275                 280                 285             


His Asp Tyr Pro Arg Pro Lys Phe Tyr Ile Asp Lys Leu Gly Asp Ile 
    290                 295                 300                 


Tyr Thr Leu Thr Asn Asn Glu Leu 
305                 310         


<210>  10
<211>  300
<212>  PRT
<213>  Pichia kudriavzevii

<400>  10

Met Thr Ile Lys Ile Ala Thr Arg Gly Ala Ala Glu Lys Ile Leu Asp 
1               5                   10                  15      


Lys Tyr Asp Thr Tyr Leu Phe Asp Cys Asp Gly Val Ile Trp Ile Gly 
            20                  25                  30          


Asn Glu Leu Leu Pro Ser Val Lys Glu Thr Leu Glu Leu Leu Gln Ser 
        35                  40                  45              


Lys Lys Lys Asn Leu Ile Phe Val Ser Asn Asn Ser Thr Lys Ala Arg 
    50                  55                  60                  


Asp Gln Tyr Ile Glu Lys Leu Ala Gly Leu Gly Ile His Gly Val Glu 
65                  70                  75                  80  


Leu Glu Gln Ile Ile Asn Ser Cys Tyr Ser Thr Ala Ile Tyr Ile Asn 
                85                  90                  95      


Glu Val Leu Gln Leu Asp Lys Ala Lys Lys Ile Trp Val Leu Gly Gln 
            100                 105                 110         


Glu Gly Ile Thr Lys Glu Val Glu Lys Phe Gly Tyr Glu Thr Val Thr 
        115                 120                 125             


Phe Lys Asp Leu Glu Ala Lys Phe Gln Glu Glu Glu Leu Thr Val Asp 
    130                 135                 140                 


Asn Ile Gln Ser Leu Ile Asp Pro Gln Val Gly Cys Val Ile Val Gly 
145                 150                 155                 160 


Leu Asp Phe Gln Val Thr Tyr Leu Lys Ile Ala Ile Thr Gln Gln Tyr 
                165                 170                 175     


Leu Phe Asp Arg Lys Ile Pro Phe Ile Ala Thr Asn Ile Asp Ser Thr 
            180                 185                 190         


Phe Pro Phe Gly Lys Thr Lys Leu Pro Gly Ala Gly Ser Ile Val Glu 
        195                 200                 205             


Val Ala Ser Phe Cys Ser Gly Arg Glu Pro Asp Ala Ile Cys Gly Lys 
    210                 215                 220                 


Pro Gln Ser Gly Met Met Asp Ser Ile Leu Ser His His Ser Leu Asn 
225                 230                 235                 240 


Lys Glu Thr Thr Ile Met Val Gly Asp Arg Leu Asn Thr Asp Met Lys 
                245                 250                 255     


Phe Gly Ser Val Asn Gly Ile Asp Thr Leu Leu Val Leu Thr Gly Ile 
            260                 265                 270         


Glu Val Glu Glu Ser Val Ala Asn Gly His Ser Asp Val Thr Tyr Tyr 
        275                 280                 285             


Ala Asp Lys Leu Gly Asp Leu Tyr Asp Leu Thr Lys 
    290                 295                 300 


<210>  11
<211>  384
<212>  PRT
<213>  Pichia kudriavzevii

<400>  11

Met Thr Asn Ser Glu Ile Gln Arg Met Ser Thr Pro Val Glu Glu Val 
1               5                   10                  15      


Ser Gln Gln Leu Glu Ser Lys Gln Asp Ile Gly Phe Val Phe Asp Ile 
            20                  25                  30          


Asp Gly Val Leu Leu Lys Gly Lys Lys Arg Ile Val Glu Ala Thr Glu 
        35                  40                  45              


Ile Ile Thr Tyr Leu Gln Lys Glu Lys Ile Pro Phe Ile Leu Leu Thr 
    50                  55                  60                  


Asn Gly Gly Gly Met Thr Glu Lys Lys Arg Ile Asp Phe Ile Asn Met 
65                  70                  75                  80  


Thr Leu Gln Leu Glu Thr Pro Ile His Pro Asp Gln Leu Ile Gln Ala 
                85                  90                  95      


His Thr Pro Met Lys Thr Leu Ile Pro His His Lys Arg Val Leu Ile 
            100                 105                 110         


Cys Gly Gly Pro Lys Asp Asp Val Arg Glu Val Ala Glu Ser Tyr Gly 
        115                 120                 125             


Phe Glu Asp Val Ile Arg Pro Val Asp Ile Ile Arg Ala Asn Pro Thr 
    130                 135                 140                 


Ile Trp Pro Tyr His Met Phe Thr Asp Glu Gln Ile Glu Gln Trp Gly 
145                 150                 155                 160 


Arg Asp Pro Asn Asp Thr Lys Leu Asp Val Asp Gly Thr Gly Cys Lys 
                165                 170                 175     


Glu Asn Leu Pro Ile Asp Ser Ile Leu Cys Phe Asn Asp Ser Arg Ala 
            180                 185                 190         


Leu Gly Ala Glu Ile Gln Ile Ile Ser Asp Leu Leu Asn Ser Glu Asn 
        195                 200                 205             


Gly Val Leu Gly Thr Arg Arg Thr Val Lys Ser Ser Lys Pro Ser Ile 
    210                 215                 220                 


Pro Ile Val Phe Ser Asn Asn Asp Phe Leu Trp Ala Asn Glu Phe Val 
225                 230                 235                 240 


Gln Pro Arg Phe Ala Met Gly Val Leu Lys Ile Ala Thr Gln Thr Ile 
                245                 250                 255     


Tyr Ser Lys Ile Asn Gly Gly Glu Glu Leu Glu Gln Leu Thr Leu Gly 
            260                 265                 270         


Lys Pro Glu Lys Val Cys Tyr Asp Tyr Ala His His Ile Leu Ile Asp 
        275                 280                 285             


Trp Arg Asp Val Leu Leu Gly Lys Lys Lys Ala Gly Asn Val Cys Leu 
    290                 295                 300                 


Pro Gln Leu Asn Asn Glu Pro Leu Asn Ser Pro Phe Lys Lys Val Tyr 
305                 310                 315                 320 


Met Val Gly Asp Asn Pro Glu Ser Asp Ile Thr Gly Gly Asn Arg Tyr 
                325                 330                 335     


Asn Trp Gly Thr Ile Leu Val Lys Thr Gly Val Tyr Gln Glu Gly Asp 
            340                 345                 350         


Phe Glu Arg Asn Pro Glu Ile Ser Lys Pro Ser Leu Gly Val Phe Ala 
        355                 360                 365             


Asn Val Lys Glu Gly Val Met His Ala Leu Lys Leu Asn Gly Leu Ala 
    370                 375                 380                 


<210>  12
<211>  362
<212>  PRT
<213>  Pichia kudriavzevii

<400>  12

Met Leu Ser Leu Gln Phe Lys Arg Leu Ile His Ser Ile Lys Lys Ser 
1               5                   10                  15      


Pro Val Gly Phe Ala Phe Asp Ile Asp Gly Val Leu Met Gln Ser Lys 
            20                  25                  30          


Asn Pro Ile Leu Pro Tyr Ala Arg Asp Thr Leu Thr Leu Leu Gln Asp 
        35                  40                  45              


His Lys Ile Pro Phe Val Leu Leu Thr Asn Gly Gly Gly Gln Thr Glu 
    50                  55                  60                  


Ala Ser Arg Val Ser Phe Leu Asn Lys Ser Leu Ser Leu Lys Asn Pro 
65                  70                  75                  80  


Leu Arg Thr Ser Gln Ile Val Leu Ser His Thr Pro Met Arg Asn Leu 
                85                  90                  95      


Thr Gly Lys Tyr Asn Arg Val Leu Val Val Gly Gly Asp Asp Pro Gln 
            100                 105                 110         


Thr Arg Glu Val Ala Gln Ser Tyr Gly Phe Gln Glu Val Ile Arg Pro 
        115                 120                 125             


Ile Asp Ile Val Arg Glu Ala Pro Asn Ile Trp Pro Phe Ile Arg Tyr 
    130                 135                 140                 


Thr Arg Glu Glu Ile Gln Ala Leu Ser Lys Pro Val Asp Leu Arg Gln 
145                 150                 155                 160 


Pro Ile Asp Ala Ala Phe Val Phe Asn Asp Pro Arg Asp Met Gly Thr 
                165                 170                 175     


Asp Thr Gln Ile Val Ile Asp Ala Leu Cys Ser Glu Asn Gly Val Leu 
            180                 185                 190         


Gly Thr Arg Arg Gly Ile Gly Ser Ser Lys Pro Ser Val Pro Ile Ile 
        195                 200                 205             


Phe Ser Asn Met Asp Leu Leu Trp Ser Thr Gly Tyr Pro Ile Pro Arg 
    210                 215                 220                 


Phe Gly Gln Gly Ala Phe Arg Leu Thr Ile Arg Glu Leu Tyr Lys Gln 
225                 230                 235                 240 


Leu Asn Asn Ala Glu Leu Glu Asp Ile Val Leu Gly Lys Pro Trp Pro 
                245                 250                 255     


Val Ser Tyr Thr Tyr Ala Glu Asn Val Leu Asn Asp Glu Trp Lys Leu 
            260                 265                 270         


Leu Asn Gly Asp Arg Ser Gly Ala Asn Glu Ile Pro Glu Leu Gly Val 
        275                 280                 285             


Lys Pro Lys Glu Gln Leu Val Glu Asn Val Tyr Met Val Gly Asp Asn 
    290                 295                 300                 


Pro Gln Ser Asp Ile Ser Gly Gly Asn Asn Tyr Gly Trp Glu Thr Ile 
305                 310                 315                 320 


Leu Val Glu Thr Gly Val Tyr Lys Glu Gly Asp Phe His Lys Tyr Pro 
                325                 330                 335     


Thr Leu Ala Lys Pro Thr Phe Gly Ile Phe Pro Asn Val Trp Asp Gly 
            340                 345                 350         


Val Thr Ser Ala Leu Lys Arg His Gln Val 
        355                 360         


<210>  13
<211>  352
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  13

Met Ile Gly Lys Arg Phe Phe Gln Thr Thr Ser Lys Lys Ile Ala Phe 
1               5                   10                  15      


Ala Phe Asp Ile Asp Gly Val Leu Phe Arg Gly Lys Lys Pro Ile Ala 
            20                  25                  30          


Gly Ala Ser Asp Ala Leu Lys Leu Leu Asn Arg Asn Lys Ile Pro Tyr 
        35                  40                  45              


Ile Leu Leu Thr Asn Gly Gly Gly Phe Ser Glu Arg Ala Arg Thr Glu 
    50                  55                  60                  


Phe Ile Ser Ser Lys Leu Asp Val Asp Val Ser Pro Leu Gln Ile Ile 
65                  70                  75                  80  


Gln Ser His Thr Pro Tyr Lys Ser Leu Val Asn Lys Tyr Ser Arg Ile 
                85                  90                  95      


Leu Ala Val Gly Thr Pro Ser Val Arg Gly Val Ala Glu Gly Tyr Gly 
            100                 105                 110         


Phe Gln Asp Val Val His Gln Thr Asp Ile Val Arg Tyr Asn Arg Asp 
        115                 120                 125             


Ile Ala Pro Phe Ser Gly Leu Ser Asp Glu Gln Val Met Glu Tyr Ser 
    130                 135                 140                 


Arg Asp Ile Pro Asp Leu Thr Thr Lys Lys Phe Asp Ala Val Leu Val 
145                 150                 155                 160 


Phe Asn Asp Pro His Asp Trp Ala Ala Asp Ile Gln Ile Ile Ser Asp 
                165                 170                 175     


Ala Ile Asn Ser Glu Asn Gly Met Leu Asn Thr Leu Arg Asn Glu Lys 
            180                 185                 190         


Ser Gly Lys Pro Ser Ile Pro Ile Tyr Phe Ser Asn Gln Asp Leu Leu 
        195                 200                 205             


Trp Ala Asn Pro Tyr Lys Leu Asn Arg Phe Gly Gln Gly Ala Phe Arg 
    210                 215                 220                 


Leu Leu Val Arg Arg Leu Tyr Leu Glu Leu Asn Gly Glu Pro Leu Gln 
225                 230                 235                 240 


Asp Tyr Thr Leu Gly Lys Pro Thr Lys Leu Thr Tyr Asp Phe Ala His 
                245                 250                 255     


His Val Leu Ile Asp Trp Glu Lys Arg Leu Ser Gly Lys Ile Gly Gln 
            260                 265                 270         


Ser Val Lys Gln Lys Leu Pro Leu Leu Gly Thr Lys Pro Ser Thr Ser 
        275                 280                 285             


Pro Phe His Ala Val Phe Met Val Gly Asp Asn Pro Ala Ser Asp Ile 
    290                 295                 300                 


Ile Gly Ala Gln Asn Tyr Gly Trp Asn Ser Cys Leu Val Lys Thr Gly 
305                 310                 315                 320 


Val Tyr Asn Glu Gly Asp Asp Leu Lys Glu Cys Lys Pro Thr Leu Ile 
                325                 330                 335     


Val Asn Asp Val Phe Asp Ala Val Thr Lys Thr Leu Glu Lys Tyr Ala 
            340                 345                 350         


<210>  14
<211>  249
<212>  PRT
<213>  Pichia kudriavzevii

<400>  14

Met Val His Lys Leu Ile Leu Val Arg His Gly Gln Ser Glu Trp Asn 
1               5                   10                  15      


Glu Lys Asn Leu Phe Thr Gly Trp Val Asp Val Lys Leu Ser Glu Lys 
            20                  25                  30          


Gly Arg Gln Glu Ala Val Arg Ala Gly Glu Leu Leu Lys Glu Ala Asp 
        35                  40                  45              


Ile Lys Pro Asp Val Leu Tyr Thr Ser Leu Leu Thr Arg Ala Ile Gln 
    50                  55                  60                  


Thr Ala Asn Ile Ala Leu Glu Asn Ala Asp Arg Leu His Ile Pro Val 
65                  70                  75                  80  


Val Arg Ser Trp Arg Leu Asn Glu Arg His Tyr Gly Ala Leu Gln Gly 
                85                  90                  95      


Lys Asp Lys Ala Gln Thr Leu Glu Thr Tyr Gly Pro Glu Lys Phe Gln 
            100                 105                 110         


Gln Trp Arg Arg Ser Phe Asp Ile Pro Pro Pro Pro Ile Glu Asp His 
        115                 120                 125             


Ser Glu Phe Ser Gln Phe Gly Glu Glu Arg Tyr Ser Asn Val Asp Pro 
    130                 135                 140                 


Asn Val Leu Pro Lys Thr Glu Ser Leu Ala Leu Val Ile Asp Arg Leu 
145                 150                 155                 160 


Leu Pro Phe Trp Gln Asp Val Ile Ala Lys Asp Leu Leu Ala Asn Lys 
                165                 170                 175     


Thr Val Ile Ile Thr Ala His Gly Asn Ser Leu Arg Gly Leu Val Lys 
            180                 185                 190         


His Leu Asp Asn Ile Ser Asp Asp Asp Ile Ala Gly Leu Asn Ile Pro 
        195                 200                 205             


Thr Ala Ile Pro Leu Val Tyr Glu Leu Asp Asp Asn Leu Lys Pro Ile 
    210                 215                 220                 


Lys Pro Ala Tyr Tyr Leu Asp Pro Glu Ala Ala Ala Ala Gly Ala Ala 
225                 230                 235                 240 


Ala Val Ala Ala Gln Gly Gln Lys Lys 
                245                 


<210>  15
<211>  469
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  15

Met Thr Ser Ile Asp Ile Asn Asn Leu Gln Asn Thr Phe Gln Gln Ala 
1               5                   10                  15      


Met Asn Met Ser Gly Ser Pro Gly Ala Val Cys Thr Ser Pro Thr Gln 
            20                  25                  30          


Ser Phe Met Asn Thr Val Pro Gln Arg Leu Asn Ala Val Lys His Pro 
        35                  40                  45              


Lys Ile Leu Lys Pro Phe Ser Thr Gly Asp Met Lys Ile Leu Leu Leu 
    50                  55                  60                  


Glu Asn Val Asn Gln Thr Ala Ile Thr Ile Phe Glu Glu Gln Gly Tyr 
65                  70                  75                  80  


Gln Val Glu Phe Tyr Lys Ser Ser Leu Pro Glu Glu Glu Leu Ile Glu 
                85                  90                  95      


Lys Ile Lys Asp Val His Ala Ile Gly Ile Arg Ser Lys Thr Arg Leu 
            100                 105                 110         


Thr Ser Asn Val Leu Gln His Ala Lys Asn Leu Val Cys Ile Gly Cys 
        115                 120                 125             


Phe Cys Ile Gly Thr Asn Gln Val Asp Leu Asp Tyr Ala Thr Ser Arg 
    130                 135                 140                 


Gly Ile Ala Val Phe Asn Ser Pro Phe Ser Asn Ser Arg Ser Val Ala 
145                 150                 155                 160 


Glu Leu Val Ile Ala Glu Ile Ile Ser Leu Ala Arg Gln Leu Gly Asp 
                165                 170                 175     


Arg Ser Ile Glu Leu His Thr Gly Thr Trp Asn Lys Val Ala Ala Arg 
            180                 185                 190         


Cys Trp Glu Val Arg Gly Lys Thr Leu Gly Ile Ile Gly Tyr Gly His 
        195                 200                 205             


Ile Gly Ser Gln Leu Ser Val Leu Ala Glu Ala Met Gly Leu His Val 
    210                 215                 220                 


Leu Tyr Tyr Asp Ile Val Thr Ile Met Ala Leu Gly Thr Ala Arg Gln 
225                 230                 235                 240 


Val Ser Thr Leu Asp Glu Leu Leu Asn Lys Ser Asp Phe Val Thr Leu 
                245                 250                 255     


His Val Pro Ala Thr Pro Glu Thr Glu Lys Met Leu Ser Ala Pro Gln 
            260                 265                 270         


Phe Ala Ala Met Lys Asp Gly Ala Tyr Val Ile Asn Ala Ser Arg Gly 
        275                 280                 285             


Thr Val Val Asp Ile Pro Ser Leu Ile Gln Ala Val Lys Ala Asn Lys 
    290                 295                 300                 


Ile Ala Gly Ala Ala Leu Asp Val Tyr Pro His Glu Pro Ala Lys Asn 
305                 310                 315                 320 


Gly Glu Gly Ser Phe Asn Asp Glu Leu Asn Ser Trp Thr Ser Glu Leu 
                325                 330                 335     


Val Ser Leu Pro Asn Ile Ile Leu Thr Pro His Ile Gly Gly Ser Thr 
            340                 345                 350         


Glu Glu Ala Gln Ser Ser Ile Gly Ile Glu Val Ala Thr Ala Leu Ser 
        355                 360                 365             


Lys Tyr Ile Asn Glu Gly Asn Ser Val Gly Ser Val Asn Phe Pro Glu 
    370                 375                 380                 


Val Ala Leu Lys Ser Leu Ser Tyr Asp Gln Glu Asn Thr Val Arg Val 
385                 390                 395                 400 


Leu Tyr Ile His Gln Asn Val Pro Gly Val Leu Lys Thr Val Asn Asp 
                405                 410                 415     


Ile Leu Ser Asn His Asn Ile Glu Lys Gln Phe Ser Asp Ser Asn Gly 
            420                 425                 430         


Glu Ile Ala Tyr Leu Met Ala Asp Ile Ser Ser Val Asp Gln Ser Asp 
        435                 440                 445             


Ile Lys Asp Ile Tyr Glu Gln Leu Asn Gln Thr Ser Ala Lys Ile Ser 
    450                 455                 460                 


Ile Arg Leu Leu Tyr 
465                 


<210>  16
<211>  381
<212>  PRT
<213>  Escherichia coli

<400>  16

Met Lys Ile Val Ile Ala Pro Asp Ser Phe Lys Glu Ser Leu Ser Ala 
1               5                   10                  15      


Glu Lys Cys Cys Gln Ala Ile Lys Ala Gly Phe Ser Thr Leu Phe Pro 
            20                  25                  30          


Asp Ala Asn Tyr Ile Cys Leu Pro Ile Ala Asp Gly Gly Glu Gly Thr 
        35                  40                  45              


Val Asp Ala Met Val Ala Ala Thr Gly Gly Asn Ile Val Thr Leu Glu 
    50                  55                  60                  


Val Cys Gly Pro Met Gly Glu Lys Val Asn Ala Phe Tyr Gly Leu Thr 
65                  70                  75                  80  


Gly Asp Gly Lys Thr Ala Val Ile Glu Met Ala Ala Ala Ser Gly Leu 
                85                  90                  95      


Met Leu Val Ala Pro Glu Lys Arg Asn Pro Leu Leu Ala Ser Ser Phe 
            100                 105                 110         


Gly Thr Gly Glu Leu Ile Arg His Ala Leu Asp Asn Asp Ile Arg His 
        115                 120                 125             


Ile Ile Leu Gly Ile Gly Gly Ser Ala Thr Val Asp Gly Gly Met Gly 
    130                 135                 140                 


Met Ala Gln Ala Leu Gly Val Arg Phe Leu Asp Ala Asp Gly Gln Ala 
145                 150                 155                 160 


Leu Ala Ala Asn Gly Gly Asn Leu Ala Arg Val Ala Ser Ile Glu Met 
                165                 170                 175     


Asp Glu Cys Asp Pro Arg Leu Ala Asn Cys His Ile Glu Val Ala Cys 
            180                 185                 190         


Asp Val Asp Asn Pro Leu Val Gly Ala Arg Gly Ala Ala Ala Val Phe 
        195                 200                 205             


Gly Pro Gln Lys Gly Ala Thr Pro Glu Met Val Glu Glu Leu Glu Gln 
    210                 215                 220                 


Gly Leu Gln Asn Tyr Ala Arg Val Leu Gln Gln Gln Thr Glu Ile Asn 
225                 230                 235                 240 


Val Cys Gln Met Ala Gly Gly Gly Ala Ala Gly Gly Met Gly Ile Ala 
                245                 250                 255     


Ala Ala Val Phe Leu Asn Ala Asp Ile Lys Pro Gly Ile Glu Ile Val 
            260                 265                 270         


Leu Asn Ala Val Asn Leu Ala Gln Ala Val Gln Gly Ala Ala Leu Val 
        275                 280                 285             


Ile Thr Gly Glu Gly Arg Ile Asp Ser Gln Thr Ala Gly Gly Lys Ala 
    290                 295                 300                 


Pro Leu Gly Val Ala Ser Val Ala Lys Gln Phe Asn Val Pro Val Ile 
305                 310                 315                 320 


Gly Ile Ala Gly Val Leu Gly Asp Gly Val Glu Val Val His Gln Tyr 
                325                 330                 335     


Gly Ile Asp Ala Val Phe Ser Ile Leu Pro Arg Leu Ala Pro Leu Ala 
            340                 345                 350         


Glu Val Leu Ala Ser Gly Glu Thr Asn Leu Phe Asn Ser Ala Arg Asn 
        355                 360                 365             


Ile Ala Cys Ala Ile Lys Ile Gly Gln Gly Ile Lys Asn 
    370                 375                 380     


<210>  17
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  17

Met Ser Ser Pro Gln Asp Ile Asn Asn Leu Gln Asn Asp Leu Leu Ala 
1               5                   10                  15      


Arg Ala Arg Ser Phe Gln Gln Ala Leu Asn Leu Ser Gly Ser Pro Gly 
            20                  25                  30          


Asn Ala Val Ser Thr Ser Pro Pro Thr Ser Phe Gly Gly Ser Phe Met 
        35                  40                  45              


Asn Gln Leu Pro Arg Arg Leu Ser Arg Thr Ala Ala Ser Lys Pro Ala 
    50                  55                  60                  


Lys Ala Leu Lys Pro Phe Ser Thr Gly Asp Ile Lys Ile Leu Leu Leu 
65                  70                  75                  80  


Glu Asn Val Asn Gln Thr Ala Arg Asp Ile Phe Lys Glu Gln Gly Tyr 
                85                  90                  95      


Gln Val Glu Phe Leu Lys Ser Ser Leu Pro Glu Asp Glu Leu Ile Glu 
            100                 105                 110         


Lys Ile Arg Asp Val His Ala Ile Gly Ile Arg Ser Lys Thr Lys Leu 
        115                 120                 125             


Thr Ala Lys Val Leu Lys His Ala Lys Asn Leu Ile Val Ile Gly Cys 
    130                 135                 140                 


Phe Cys Ile Gly Thr Asn Gln Val Asp Leu Glu Tyr Ala Ala Lys His 
145                 150                 155                 160 


Gly Ile Ala Val Phe Asn Ser Pro Phe Ser Asn Ser Arg Ser Val Ala 
                165                 170                 175     


Glu Leu Val Ile Ala Glu Ile Ile Ser Leu Ala Arg Gln Leu Gly Asp 
            180                 185                 190         


Arg Ser Ile Glu Met His Thr Gly Thr Trp Asn Lys Val Ser Ala Lys 
        195                 200                 205             


Cys Trp Glu Ile Arg Gly Lys Thr Leu Gly Ile Ile Gly Tyr Gly His 
    210                 215                 220                 


Ile Gly Ser Gln Leu Ser Val Leu Ala Glu Ala Met Gly Met Asn Val 
225                 230                 235                 240 


Ile Tyr Tyr Asp Val Val Thr Ile Met Ala Leu Gly Thr Ala Lys Gln 
                245                 250                 255     


Val Pro Thr Leu Asp Glu Leu Leu Asn Lys Ala Asp Phe Val Thr Leu 
            260                 265                 270         


His Val Pro Glu Thr Pro Glu Thr Lys Asn Met Ile Ser Ala Pro Gln 
        275                 280                 285             


Phe Ala Ala Met Lys Asp Gly Ala Tyr Leu Ile Asn Ala Ser Arg Gly 
    290                 295                 300                 


Thr Val Val Asp Ile Pro Ala Leu Ile Gln Ala Met Lys Ser Gly Lys 
305                 310                 315                 320 


Ile Ala Gly Ala Ala Leu Asp Val Tyr Pro Asn Glu Pro Ala Lys Asn 
                325                 330                 335     


Gly Asp Gly Tyr Phe Asn Asp Asp Leu Asn Ser Trp Ala Ser Glu Leu 
            340                 345                 350         


Arg Ser Leu Lys Asn Val Ile Leu Thr Pro His Ile Gly Gly Ser Thr 
        355                 360                 365             


Glu Glu Ala Gln Ser Ala Ile Gly Val Glu Val Ala Thr Ala Leu Val 
    370                 375                 380                 


Lys Tyr Ile Asn Glu Gly Asn Ser Leu Gly Ala Val Asn Phe Pro Glu 
385                 390                 395                 400 


Val Ser Leu Arg Ser Leu Thr Leu Asp Gln Pro Asn His Val Arg Val 
                405                 410                 415     


Leu Tyr Ile His Gln Asn Val Pro Gly Val Leu Arg Thr Val Asn Glu 
            420                 425                 430         


Ile Leu Ser Asn His Asn Ile Glu Lys Gln Phe Ser Asp Ser Arg Gly 
        435                 440                 445             


Asp Ile Ala Tyr Leu Met Ala Asp Ile Ser Asp Val Asp Gln Ser Asp 
    450                 455                 460                 


Ile Lys Asp Leu Tyr Glu Gln Leu Glu Gln Thr Ser Ser Lys Ile Ser 
465                 470                 475                 480 


Thr Arg Leu Leu Tyr Leu 
                485     


<210>  18
<211>  381
<212>  PRT
<213>  Escherichia coli

<400>  18

Met Lys Ile Val Ile Ala Pro Asp Ser Tyr Lys Glu Ser Leu Ser Ala 
1               5                   10                  15      


Ser Glu Val Ala Gln Ala Ile Glu Lys Gly Phe Arg Glu Ile Phe Pro 
            20                  25                  30          


Asp Ala Gln Tyr Val Ser Val Pro Val Ala Asp Gly Gly Glu Gly Thr 
        35                  40                  45              


Val Glu Ala Met Ile Ala Ala Thr Gln Gly Ala Glu Arg His Ala Trp 
    50                  55                  60                  


Val Thr Gly Pro Leu Gly Glu Lys Val Asn Ala Ser Trp Gly Ile Ser 
65                  70                  75                  80  


Gly Asp Gly Lys Thr Ala Phe Ile Glu Met Ala Ala Ala Ser Gly Leu 
                85                  90                  95      


Glu Leu Val Pro Ala Glu Lys Arg Asp Pro Leu Val Thr Thr Ser Arg 
            100                 105                 110         


Gly Thr Gly Glu Leu Ile Leu Gln Ala Leu Glu Ser Gly Ala Thr Asn 
        115                 120                 125             


Ile Ile Ile Gly Ile Gly Gly Ser Ala Thr Asn Asp Gly Gly Ala Gly 
    130                 135                 140                 


Met Val Gln Ala Leu Gly Ala Lys Leu Cys Asp Ala Asn Gly Asn Glu 
145                 150                 155                 160 


Ile Gly Phe Gly Gly Gly Ser Leu Asn Thr Leu Asn Asp Ile Asp Ile 
                165                 170                 175     


Ser Gly Leu Asp Pro Arg Leu Lys Asp Cys Val Ile Arg Val Ala Cys 
            180                 185                 190         


Asp Val Thr Asn Pro Leu Val Gly Asp Asn Gly Ala Ser Arg Ile Phe 
        195                 200                 205             


Gly Pro Gln Lys Gly Ala Ser Glu Ala Met Ile Val Glu Leu Asp Asn 
    210                 215                 220                 


Asn Leu Ser His Tyr Ala Glu Val Ile Lys Lys Ala Leu His Val Asp 
225                 230                 235                 240 


Val Lys Asp Val Pro Gly Ala Gly Ala Ala Gly Gly Met Gly Ala Ala 
                245                 250                 255     


Leu Met Ala Phe Leu Gly Ala Glu Leu Lys Ser Gly Ile Glu Ile Val 
            260                 265                 270         


Thr Thr Ala Leu Asn Leu Glu Glu His Ile His Asp Cys Thr Leu Val 
        275                 280                 285             


Ile Thr Gly Glu Gly Arg Ile Asp Ser Gln Ser Ile His Gly Lys Val 
    290                 295                 300                 


Pro Ile Gly Val Ala Asn Val Ala Lys Lys Tyr His Lys Pro Val Ile 
305                 310                 315                 320 


Gly Ile Ala Gly Ser Leu Thr Asp Asp Val Gly Val Val His Gln His 
                325                 330                 335     


Gly Ile Asp Ala Val Phe Ser Val Leu Thr Ser Ile Gly Thr Leu Asp 
            340                 345                 350         


Glu Ala Phe Arg Gly Ala Tyr Asp Asn Ile Cys Arg Ala Ser Arg Asn 
        355                 360                 365             


Ile Ala Ala Thr Leu Ala Ile Gly Met Arg Asn Ala Gly 
    370                 375                 380     


<210>  19
<211>  388
<212>  PRT
<213>  Pichia kudriavzevii

<400>  19

Met Val Ser Pro Ala Glu Arg Leu Ser Thr Ile Ala Ser Thr Ile Lys 
1               5                   10                  15      


Pro Asn Arg Lys Asp Ser Thr Ser Leu Gln Pro Glu Asp Tyr Pro Glu 
            20                  25                  30          


His Pro Phe Lys Val Thr Val Val Gly Ser Gly Asn Trp Gly Cys Thr 
        35                  40                  45              


Ile Ala Lys Val Ile Ala Glu Asn Thr Val Glu Arg Pro Arg Gln Phe 
    50                  55                  60                  


Gln Arg Asp Val Asn Met Trp Val Tyr Glu Glu Leu Ile Glu Gly Glu 
65                  70                  75                  80  


Lys Leu Thr Glu Ile Ile Asn Thr Lys His Glu Asn Val Lys Tyr Leu 
                85                  90                  95      


Pro Gly Ile Lys Leu Pro Val Asn Val Val Ala Val Pro Asp Ile Val 
            100                 105                 110         


Glu Ala Cys Ala Gly Ser Asp Leu Ile Val Phe Asn Ile Pro His Gln 
        115                 120                 125             


Phe Leu Pro Arg Ile Leu Ser Gln Leu Lys Gly Lys Val Asn Pro Lys 
    130                 135                 140                 


Ala Arg Ala Ile Ser Cys Leu Lys Gly Leu Asp Val Asn Pro Asn Gly 
145                 150                 155                 160 


Cys Lys Leu Leu Ser Thr Val Ile Thr Glu Glu Leu Gly Ile Tyr Cys 
                165                 170                 175     


Gly Ala Leu Ser Gly Ala Asn Leu Ala Pro Glu Val Ala Gln Cys Lys 
            180                 185                 190         


Trp Ser Glu Thr Thr Val Ala Tyr Thr Ile Pro Asp Asp Phe Arg Gly 
        195                 200                 205             


Lys Gly Lys Asp Ile Asp His Gln Ile Leu Lys Ser Leu Phe His Arg 
    210                 215                 220                 


Pro Tyr Phe His Val Arg Val Ile Ser Asp Val Ala Gly Ile Ser Ile 
225                 230                 235                 240 


Ala Gly Ala Leu Lys Asn Val Val Ala Met Ala Ala Gly Phe Val Glu 
                245                 250                 255     


Gly Leu Gly Trp Gly Asp Asn Ala Lys Ala Ala Val Met Arg Ile Gly 
            260                 265                 270         


Leu Val Glu Thr Ile Gln Phe Ala Lys Thr Phe Phe Asp Gly Cys His 
        275                 280                 285             


Ala Ala Thr Phe Thr His Glu Ser Ala Gly Val Ala Asp Leu Ile Thr 
    290                 295                 300                 


Thr Cys Ala Gly Gly Arg Asn Val Arg Val Gly Arg Tyr Met Ala Gln 
305                 310                 315                 320 


His Ser Val Ser Ala Thr Glu Ala Glu Glu Lys Leu Leu Asn Gly Gln 
                325                 330                 335     


Ser Cys Gln Gly Ile His Thr Thr Arg Glu Val Tyr Glu Phe Leu Ser 
            340                 345                 350         


Asn Met Gly Arg Thr Asp Glu Phe Pro Leu Phe Thr Thr Thr Tyr Arg 
        355                 360                 365             


Ile Ile Tyr Glu Asn Phe Pro Ile Glu Lys Leu Pro Glu Cys Leu Glu 
    370                 375                 380                 


Pro Val Glu Asp 
385             


<210>  20
<211>  563
<212>  PRT
<213>  Pichia kudriavzevii

<400>  20

Met Ile Pro Arg Leu Asn Pro Leu Leu Asn Ile Ser His Leu Arg Gly 
1               5                   10                  15      


Gly Pro Lys Phe Ile Gly Lys Ala Ile Lys Pro Ser Gln Phe Glu Phe 
            20                  25                  30          


Arg Lys Asn Asn Phe Arg Phe Asn Ser Thr Ser Thr Lys Thr Gly Ser 
        35                  40                  45              


Ala Arg Thr Ile Lys Ser Gly Phe Leu Ser Trp Ser Phe Arg Ala Ala 
    50                  55                  60                  


Thr Phe Thr Gly Ile Ala Gly Trp Leu Tyr Leu Thr Tyr Leu Val Tyr 
65                  70                  75                  80  


Lys Glu Thr Asn Pro Gly Ser Gln Ser Pro Gln Thr Glu Phe Ser Glu 
                85                  90                  95      


Ile Gly Asn Lys Lys Lys Asn Ile Val Ile Leu Gly Ser Gly Trp Gly 
            100                 105                 110         


Ala Val Ser Val Leu Lys Thr Leu Asp Thr Thr Lys Tyr Asn Val Thr 
        115                 120                 125             


Ile Val Ser Pro Arg Asn Tyr Phe Leu Phe Thr Pro Leu Leu Pro Ser 
    130                 135                 140                 


Val Pro Ser Gly Thr Ile Asp Ile Lys Ser Ile Cys Asp Ser Ile Arg 
145                 150                 155                 160 


Thr Ile Ala Arg Gln Thr Pro Gly Glu Val Thr Tyr Leu Glu Ala Ala 
                165                 170                 175     


Ala Thr Asp Ile Asp Pro Val Lys Lys Thr Ile Lys Leu Glu His Lys 
            180                 185                 190         


Ser Gln Arg Phe Leu Ile Gly Asp Ala Phe Thr Ser Glu Gly Asp Val 
        195                 200                 205             


Ile Glu Asn Glu Leu Ser Tyr Asp Tyr Leu Val Tyr Ala Val Gly Ala 
    210                 215                 220                 


Thr Val Asn Thr Phe Gly Ile Pro Gly Ile Pro Glu Tyr Ala Ser Tyr 
225                 230                 235                 240 


Leu Lys Glu Ala Asn Asp Ala Thr Ala Val Arg Gln Lys Leu Phe Asn 
                245                 250                 255     


Gln Ile Glu Ala Ser Arg Leu Leu Pro Lys Asp Ser Glu Asp Arg Lys 
            260                 265                 270         


Arg Leu Leu Ser Phe Val Val Cys Gly Gly Gly Pro Thr Gly Val Glu 
        275                 280                 285             


Leu Ala Ala Glu Ile Lys Asp Tyr Ile Asp Gln Asp Leu Cys Lys Phe 
    290                 295                 300                 


Ile Pro Gly Ile Glu Lys Glu Met Gln Val Thr Leu Ile Glu Ala Gln 
305                 310                 315                 320 


His Asn Val Leu Ser Met Phe His Pro Lys Leu Ile Glu Tyr Thr Lys 
                325                 330                 335     


Glu Val Phe Lys Gln Gln Asn Leu His Leu Gln Val Asp Thr Met Val 
            340                 345                 350         


Lys Lys Val Asp Asp Lys Asn Val Tyr Ala Thr Tyr Arg His Pro Asp 
        355                 360                 365             


Gly Lys Thr Glu Asp Met Val Ile Pro Tyr Gly Thr Leu Val Trp Ala 
    370                 375                 380                 


Gly Gly Asn Ala Gln Arg Lys Leu Thr Arg Asp Leu Ser Ser Lys Ile 
385                 390                 395                 400 


Ile Glu Gln Lys Thr Ala Arg Arg Gly Leu Leu Val Asp Glu Tyr Leu 
                405                 410                 415     


Lys Leu Asp Gly Asp Asp Ser Ile Tyr Ala Ile Gly Asp Cys Thr Phe 
            420                 425                 430         


Thr Pro Asn Pro Pro Thr Ala Gln Val Ala His Gln Gln Gly Glu Tyr 
        435                 440                 445             


Leu Gly Glu His Phe Asn Lys Leu Ala Lys Ile Asp Glu Leu Asn Tyr 
    450                 455                 460                 


Leu Ile Thr Asn Ser Thr Asp Asp Ser Thr Lys Tyr Ser Lys Arg Leu 
465                 470                 475                 480 


Glu Arg Ala Glu Lys Ala Ile Lys Pro Phe Glu Tyr Asp His Gln Gly 
                485                 490                 495     


Ala Leu Ala Tyr Val Gly Ser Glu Arg Ala Val Ala Asp Leu His Trp 
            500                 505                 510         


Gly Ser Trp Ser Thr Val Ala Leu Gly Gly Thr Met Thr Phe Phe Phe 
        515                 520                 525             


Trp Arg Thr Ala Tyr Val Ser Met Leu Leu Ser Ile Arg Asn Lys Ile 
    530                 535                 540                 


Leu Val Val Thr Asp Trp Val Lys Val Ala Ile Phe Gly Arg Asp Cys 
545                 550                 555                 560 


Ser Gln Glu 
            


<210>  21
<211>  446
<212>  PRT
<213>  Lactococcus lactis

<400>  21

Met Lys Ile Val Val Ile Gly Thr Asn His Ala Gly Ile Ala Thr Ala 
1               5                   10                  15      


Asn Thr Leu Ile Asp Arg Tyr Pro Gly His Glu Ile Val Met Ile Asp 
            20                  25                  30          


Arg Asn Ser Asn Met Ser Tyr Leu Gly Cys Gly Thr Ala Ile Trp Val 
        35                  40                  45              


Gly Arg Gln Ile Glu Lys Pro Asp Glu Leu Phe Tyr Ala Lys Ala Glu 
    50                  55                  60                  


Asp Phe Glu Lys Lys Gly Val Lys Ile Leu Thr Glu Thr Glu Val Ser 
65                  70                  75                  80  


Glu Ile Asp Phe Thr Asn Lys Met Ile Tyr Ala Lys Ser Lys Thr Gly 
                85                  90                  95      


Glu Lys Ile Thr Glu Ser Tyr Asp Lys Leu Val Leu Ala Thr Gly Ser 
            100                 105                 110         


Arg Pro Ile Ile Pro Asn Leu Pro Gly Lys Asp Leu Lys Gly Ile His 
        115                 120                 125             


Phe Leu Lys Leu Phe Gln Glu Gly Gln Ala Ile Asp Glu Glu Phe Ala 
    130                 135                 140                 


Lys Asn Asp Val Lys Arg Ile Ala Val Ile Gly Ala Gly Tyr Ile Gly 
145                 150                 155                 160 


Thr Glu Ile Ala Glu Ala Ala Lys Arg Arg Gly Lys Glu Val Leu Leu 
                165                 170                 175     


Phe Asp Ala Glu Ser Thr Ser Leu Ala Ser Tyr Tyr Asp Glu Glu Phe 
            180                 185                 190         


Ala Lys Gly Met Asp Glu Asn Leu Ala Gln His Gly Ile Glu Leu His 
        195                 200                 205             


Phe Gly Glu Leu Ala Gln Glu Phe Lys Ala Asn Glu Lys Gly His Val 
    210                 215                 220                 


Ser Gln Ile Val Thr Asn Lys Ser Thr Tyr Asp Val Asp Leu Val Ile 
225                 230                 235                 240 


Asn Cys Ile Gly Phe Thr Ala Asn Ser Ala Leu Ala Gly Glu His Leu 
                245                 250                 255     


Glu Thr Phe Lys Asn Gly Ala Ile Lys Val Asp Lys His Gln Gln Ser 
            260                 265                 270         


Ser Asp Pro Asp Val Ser Ala Val Gly Asp Val Ala Thr Ile Tyr Ser 
        275                 280                 285             


Asn Ala Leu Gln Asp Phe Thr Tyr Ile Ala Leu Ala Ser Asn Ala Val 
    290                 295                 300                 


Arg Ser Gly Ile Val Ala Gly His Asn Ile Gly Gly Lys Ser Ile Glu 
305                 310                 315                 320 


Ser Val Gly Val Gln Gly Ser Asn Gly Ile Ser Ile Phe Gly Tyr Asn 
                325                 330                 335     


Met Thr Ser Thr Gly Leu Ser Val Lys Ala Ala Lys Lys Ile Gly Leu 
            340                 345                 350         


Glu Val Ser Phe Ser Asp Phe Glu Asp Lys Gln Lys Ala Trp Phe Leu 
        355                 360                 365             


His Glu Asn Asn Asp Ser Val Lys Ile Arg Ile Val Tyr Glu Thr Lys 
    370                 375                 380                 


Asn Arg Arg Ile Ile Gly Ala Gln Leu Ala Ser Lys Ser Glu Ile Ile 
385                 390                 395                 400 


Ala Gly Asn Ile Asn Met Phe Ser Leu Ala Ile Gln Glu Lys Lys Thr 
                405                 410                 415     


Ile Asp Glu Leu Ala Leu Leu Asp Leu Phe Phe Leu Pro His Phe Asn 
            420                 425                 430         


Ser Pro Tyr Asn Tyr Met Thr Val Ala Ala Leu Asn Ala Lys 
        435                 440                 445     


<210>  22
<211>  1511
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  22

Met Ser Ser Thr Asp Glu His Ile Glu Lys Asp Ile Ser Ser Arg Ser 
1               5                   10                  15      


Asn His Asp Asp Asp Tyr Ala Asn Ser Val Gln Ser Tyr Ala Ala Ser 
            20                  25                  30          


Glu Gly Gln Val Asp Asn Glu Asp Leu Ala Ala Thr Ser Gln Leu Ser 
        35                  40                  45              


Arg His Leu Ser Asn Ile Leu Ser Asn Glu Glu Gly Ile Glu Arg Leu 
    50                  55                  60                  


Glu Ser Met Ala Arg Val Ile Ser His Lys Thr Lys Lys Glu Met Asp 
65                  70                  75                  80  


Ser Phe Glu Ile Asn Asp Leu Asp Phe Asp Leu Arg Ser Leu Leu His 
                85                  90                  95      


Tyr Leu Arg Ser Arg Gln Leu Glu Gln Gly Ile Glu Pro Gly Asp Ser 
            100                 105                 110         


Gly Ile Ala Phe Lys Asn Leu Thr Ala Val Gly Val Asp Ala Ser Ala 
        115                 120                 125             


Ala Tyr Gly Pro Ser Val Glu Glu Met Phe Arg Asn Ile Ala Ser Ile 
    130                 135                 140                 


Pro Ala His Leu Ile Ser Lys Phe Thr Lys Lys Ser Asp Val Pro Leu 
145                 150                 155                 160 


Arg Asn Ile Ile Gln Asn Cys Thr Gly Val Val Glu Ser Gly Glu Met 
                165                 170                 175     


Leu Phe Val Val Gly Arg Pro Gly Ala Gly Cys Ser Thr Phe Leu Lys 
            180                 185                 190         


Cys Leu Ser Gly Glu Thr Ser Glu Leu Val Asp Val Gln Gly Glu Phe 
        195                 200                 205             


Ser Tyr Asp Gly Leu Asp Gln Ser Glu Met Met Ser Lys Tyr Lys Gly 
    210                 215                 220                 


Tyr Val Ile Tyr Cys Pro Glu Leu Asp Phe His Phe Pro Lys Ile Thr 
225                 230                 235                 240 


Val Lys Glu Thr Ile Asp Phe Ala Leu Lys Cys Lys Thr Pro Arg Val 
                245                 250                 255     


Arg Ile Asp Lys Met Thr Arg Lys Gln Tyr Val Asp Asn Ile Arg Asp 
            260                 265                 270         


Met Trp Cys Thr Val Phe Gly Leu Arg His Thr Tyr Ala Thr Lys Val 
        275                 280                 285             


Gly Asn Asp Phe Val Arg Gly Val Ser Gly Gly Glu Arg Lys Arg Val 
    290                 295                 300                 


Ser Leu Val Glu Ala Gln Ala Met Asn Ala Ser Ile Tyr Ser Trp Asp 
305                 310                 315                 320 


Asn Ala Thr Arg Gly Leu Asp Ala Ser Thr Ala Leu Glu Phe Ala Gln 
                325                 330                 335     


Ala Ile Arg Thr Ala Thr Asn Met Val Asn Asn Ser Ala Ile Val Ala 
            340                 345                 350         


Ile Tyr Gln Ala Gly Glu Asn Ile Tyr Glu Leu Phe Asp Lys Thr Thr 
        355                 360                 365             


Val Leu Tyr Asn Gly Arg Gln Ile Tyr Phe Gly Pro Ala Asp Lys Ala 
    370                 375                 380                 


Val Gly Tyr Phe Gln Arg Met Gly Trp Val Lys Pro Asn Arg Met Thr 
385                 390                 395                 400 


Ser Ala Glu Phe Leu Thr Ser Val Thr Val Asp Phe Glu Asn Arg Thr 
                405                 410                 415     


Leu Asp Ile Lys Pro Gly Tyr Glu Asp Lys Val Pro Lys Ser Ser Ser 
            420                 425                 430         


Glu Phe Glu Glu Tyr Trp Leu Asn Ser Glu Asp Tyr Gln Glu Leu Leu 
        435                 440                 445             


Arg Thr Tyr Asp Asp Tyr Gln Ser Arg His Pro Val Asn Glu Thr Arg 
    450                 455                 460                 


Asp Arg Leu Asp Val Ala Lys Lys Gln Arg Leu Gln Gln Gly Gln Arg 
465                 470                 475                 480 


Glu Asn Ser Gln Tyr Val Val Asn Tyr Trp Thr Gln Val Tyr Tyr Cys 
                485                 490                 495     


Met Ile Arg Gly Phe Gln Arg Val Lys Gly Asp Ser Thr Tyr Thr Lys 
            500                 505                 510         


Val Tyr Leu Ser Ser Phe Leu Ile Lys Ala Leu Ile Ile Gly Ser Met 
        515                 520                 525             


Phe His Lys Ile Asp Asp Lys Ser Gln Ser Thr Thr Ala Gly Ala Tyr 
    530                 535                 540                 


Ser Arg Gly Gly Met Leu Phe Tyr Val Leu Leu Phe Ala Ser Val Thr 
545                 550                 555                 560 


Ser Leu Ala Glu Ile Gly Asn Ser Phe Ser Ser Arg Pro Val Ile Val 
                565                 570                 575     


Lys His Lys Ser Tyr Ser Met Tyr His Leu Ser Ala Glu Ser Leu Gln 
            580                 585                 590         


Glu Ile Ile Thr Glu Phe Pro Thr Lys Phe Val Ala Ile Val Ile Leu 
        595                 600                 605             


Cys Leu Ile Thr Tyr Trp Ile Pro Phe Met Lys Tyr Glu Ala Gly Ala 
    610                 615                 620                 


Phe Phe Gln Tyr Ile Leu Tyr Leu Leu Thr Val Gln Gln Cys Thr Ser 
625                 630                 635                 640 


Phe Ile Phe Lys Phe Val Ala Thr Met Ser Lys Ser Gly Val Asp Ala 
                645                 650                 655     


His Ala Val Gly Gly Leu Trp Val Leu Met Leu Cys Val Tyr Ala Gly 
            660                 665                 670         


Phe Val Leu Pro Ile Gly Glu Met His His Trp Ile Arg Trp Leu His 
        675                 680                 685             


Phe Ile Asn Pro Leu Thr Tyr Ala Phe Glu Ser Leu Val Ser Thr Glu 
    690                 695                 700                 


Phe His His Arg Glu Met Leu Cys Ser Ala Leu Val Pro Ser Gly Pro 
705                 710                 715                 720 


Gly Tyr Glu Gly Ile Ser Ile Ala Asn Gln Val Cys Asp Ala Ala Gly 
                725                 730                 735     


Ala Val Lys Gly Asn Leu Tyr Val Ser Gly Asp Ser Tyr Ile Leu His 
            740                 745                 750         


Gln Tyr His Phe Ala Tyr Lys His Ala Trp Arg Asn Trp Gly Val Asn 
        755                 760                 765             


Ile Val Trp Thr Phe Gly Tyr Ile Val Phe Asn Val Ile Leu Ser Glu 
    770                 775                 780                 


Tyr Leu Lys Pro Val Glu Gly Gly Gly Asp Leu Leu Leu Tyr Lys Arg 
785                 790                 795                 800 


Gly His Met Pro Glu Leu Gly Thr Glu Asn Ala Asp Ala Arg Thr Ala 
                805                 810                 815     


Ser Arg Glu Glu Met Met Glu Ala Leu Asn Gly Pro Asn Val Asp Leu 
            820                 825                 830         


Glu Lys Val Ile Ala Glu Lys Asp Val Phe Thr Trp Asn His Leu Asp 
        835                 840                 845             


Tyr Thr Ile Pro Tyr Asp Gly Ala Thr Arg Lys Leu Leu Ser Asp Val 
    850                 855                 860                 


Phe Gly Tyr Val Lys Pro Gly Lys Met Thr Ala Leu Met Gly Glu Ser 
865                 870                 875                 880 


Gly Ala Gly Lys Thr Thr Leu Leu Asn Val Leu Ala Gln Arg Ile Asn 
                885                 890                 895     


Met Gly Val Ile Thr Gly Asp Met Leu Val Asn Ala Lys Pro Leu Pro 
            900                 905                 910         


Ala Ser Phe Asn Arg Ser Cys Gly Tyr Val Ala Gln Ala Asp Asn His 
        915                 920                 925             


Met Ala Glu Leu Ser Val Arg Glu Ser Leu Arg Phe Ala Ala Glu Leu 
    930                 935                 940                 


Arg Gln Gln Ser Ser Val Pro Leu Glu Glu Lys Tyr Glu Tyr Val Glu 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Leu Gly Met Gln Asn Tyr Ala Glu Ala Leu Val 
                965                 970                 975     


Gly Lys Thr Gly Arg Gly Leu Asn Val Glu Gln Arg Lys Lys Leu Ser 
            980                 985                 990         


Ile Gly Val Glu Leu Val Ala Lys  Pro Ser Leu Leu Leu  Phe Leu Asp 
        995                 1000                 1005             


Glu Pro  Thr Ser Gly Leu Asp  Ser Gln Ser Ala Trp  Ser Ile Val 
    1010                 1015                 1020             


Gln Phe  Met Arg Ala Leu Ala  Asp Ser Gly Gln Ser  Ile Leu Cys 
    1025                 1030                 1035             


Thr Ile  His Gln Pro Ser Ala  Thr Leu Phe Glu Gln  Phe Asp Arg 
    1040                 1045                 1050             


Leu Leu  Leu Leu Lys Lys Gly  Gly Lys Met Val Tyr  Phe Gly Asp 
    1055                 1060                 1065             


Ile Gly  Pro Asn Ser Glu Thr  Leu Leu Lys Tyr Phe  Glu Arg Gln 
    1070                 1075                 1080             


Ser Gly  Met Lys Cys Gly Val  Ser Glu Asn Pro Ala  Glu Tyr Ile 
    1085                 1090                 1095             


Leu Asn  Cys Ile Gly Ala Gly  Ala Thr Ala Ser Val  Asn Ser Asp 
    1100                 1105                 1110             


Trp His  Asp Leu Trp Leu Ala  Ser Pro Glu Cys Ala  Ala Ala Arg 
    1115                 1120                 1125             


Ala Glu  Val Glu Glu Leu His  Arg Thr Leu Pro Gly  Arg Ala Val 
    1130                 1135                 1140             


Asn Asp  Asp Pro Glu Leu Ala  Thr Arg Phe Ala Ala  Ser Tyr Met 
    1145                 1150                 1155             


Thr Gln  Ile Lys Cys Val Leu  Arg Arg Thr Ala Leu  Gln Phe Trp 
    1160                 1165                 1170             


Arg Ser  Pro Val Tyr Ile Arg  Ala Lys Phe Phe Glu  Cys Val Ala 
    1175                 1180                 1185             


Cys Ala  Leu Phe Val Gly Leu  Ser Tyr Val Gly Val  Asn His Ser 
    1190                 1195                 1200             


Val Gly  Gly Ala Ile Glu Ala  Phe Ser Ser Ile Phe  Met Leu Leu 
    1205                 1210                 1215             


Leu Ile  Ala Leu Ala Met Ile  Asn Gln Leu His Val  Phe Ala Tyr 
    1220                 1225                 1230             


Asp Ser  Arg Glu Leu Tyr Glu  Val Arg Glu Ala Ala  Ser Asn Thr 
    1235                 1240                 1245             


Phe His  Trp Ser Val Leu Leu  Leu Cys His Ala Ala  Val Glu Asn 
    1250                 1255                 1260             


Phe Trp  Ser Thr Leu Cys Gln  Phe Met Cys Phe Ile  Cys Tyr Tyr 
    1265                 1270                 1275             


Trp Pro  Ala Gln Phe Ser Gly  Arg Ala Ser His Ala  Gly Phe Phe 
    1280                 1285                 1290             


Phe Phe  Phe Tyr Val Leu Ile  Phe Pro Leu Tyr Phe  Val Thr Tyr 
    1295                 1300                 1305             


Gly Leu  Trp Ile Leu Tyr Met  Ser Pro Asp Val Pro  Ser Ala Ser 
    1310                 1315                 1320             


Met Ile  Asn Ser Asn Leu Phe  Ala Ala Met Leu Leu  Phe Cys Gly 
    1325                 1330                 1335             


Ile Leu  Gln Pro Arg Glu Lys  Met Pro Ala Phe Trp  Arg Arg Leu 
    1340                 1345                 1350             


Met Tyr  Asn Val Ser Pro Phe  Thr Tyr Val Val Gln  Ala Leu Val 
    1355                 1360                 1365             


Thr Pro  Leu Val His Asn Lys  Lys Val Val Cys Asn  Pro His Glu 
    1370                 1375                 1380             


Tyr Asn  Ile Met Asp Pro Pro  Ser Gly Lys Thr Cys  Gly Glu Phe 
    1385                 1390                 1395             


Leu Ser  Thr Tyr Met Asp Asn  Asn Thr Gly Tyr Leu  Val Asn Pro 
    1400                 1405                 1410             


Thr Ala  Thr Glu Asn Cys Gln  Tyr Cys Pro Tyr Thr  Val Gln Asp 
    1415                 1420                 1425             


Gln Val  Val Ala Lys Tyr Asn  Val Lys Trp Asp His  Arg Trp Arg 
    1430                 1435                 1440             


Asn Phe  Gly Phe Met Trp Ala  Tyr Ile Cys Phe Asn  Ile Ala Ala 
    1445                 1450                 1455             


Met Leu  Ile Cys Tyr Tyr Val  Val Arg Val Lys Val  Trp Ser Leu 
    1460                 1465                 1470             


Lys Ser  Val Leu Asn Phe Lys  Lys Trp Phe Asn Gly  Pro Arg Lys 
    1475                 1480                 1485             


Glu Arg  His Glu Lys Asp Thr  Asn Ile Phe Gln Thr  Val Pro Gly 
    1490                 1495                 1500             


Asp Glu  Asn Lys Ile Thr Lys  Lys 
    1505                 1510     


<210>  23
<211>  944
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  23

Met Asp Thr Gln Ile Ala Ile Thr Gly Val Ala Val Gly Lys Glu Ile 
1               5                   10                  15      


Asn Asn Asp Asn Ser Lys Thr Asp Gln Lys Val Ser Leu Pro Lys Ala 
            20                  25                  30          


Asp Val Pro Cys Ile Asp Lys Ala Thr Gln Thr Ile Ile Glu Gly Cys 
        35                  40                  45              


Ser Lys Asp Asp Pro Arg Leu Ser Tyr Pro Thr Lys Leu Glu Thr Thr 
    50                  55                  60                  


Glu Lys Gly Lys Thr Lys Arg Asn Ser Phe Ala Cys Val Cys Cys His 
65                  70                  75                  80  


Ser Leu Lys Gln Lys Cys Glu Pro Ser Asp Val Asn Asp Ile Tyr Arg 
                85                  90                  95      


Lys Pro Cys Arg Arg Cys Leu Lys His Lys Lys Leu Cys Lys Phe Asp 
            100                 105                 110         


Leu Ser Lys Arg Thr Arg Lys Arg Lys Pro Arg Ser Arg Ser Pro Thr 
        115                 120                 125             


Pro Phe Glu Ser Pro Met Val Asn Val Ser Thr Lys Ser Lys Gly Pro 
    130                 135                 140                 


Thr Asp Ser Glu Glu Ser Ser Leu Lys Asp Gly Thr Ser Tyr Leu Ala 
145                 150                 155                 160 


Ser Phe Pro Ser Asp Pro Asn Ala Lys Gln Phe Pro Asn Ser Arg Thr 
                165                 170                 175     


Val Leu Pro Gly Leu Gln Gln Ser Leu Ser Asp Leu Trp Ser Thr Leu 
            180                 185                 190         


Ser Gln Pro Pro Ser Tyr Gly Ala Arg Glu Ala Glu Thr Thr Ser Thr 
        195                 200                 205             


Gly Glu Ile Thr Thr Asn Asn His Thr Lys Ser Asn Gly Ser Val Pro 
    210                 215                 220                 


Thr Asn Pro Ala Val Leu Ala Ser Asn Asp Glu His Thr Asn Ile Ser 
225                 230                 235                 240 


Asp Ala Pro Val Ile Tyr Ser Thr Tyr Asn Ser Pro Val Pro Ile Ser 
                245                 250                 255     


Ser Ala Pro Thr Ser Ile Asn Ser Glu Ala Leu Phe Lys His Arg Pro 
            260                 265                 270         


Lys Ile Val Gly Asp Glu Glu Thr Gln Asn Val Lys Val Lys Arg Gln 
        275                 280                 285             


Lys Lys Ser Tyr Ser Arg His Met Thr Arg Ser Phe Arg Lys Gln Leu 
    290                 295                 300                 


Gln Ser Leu Ile Ile Ser Gln Lys Gly Lys Ile Arg Asp Ile Ser Met 
305                 310                 315                 320 


Lys Leu Asp Thr Trp Ser Lys Gln Trp Asn Asp Leu Val Glu Lys Ser 
                325                 330                 335     


Met Phe Leu Pro Thr Ile Ala Asp Pro Val Ser Val Gly Ile Ile Ser 
            340                 345                 350         


His Glu Glu Ala Thr Leu Arg Leu His Leu Tyr Lys Thr Glu Ile Ser 
        355                 360                 365             


Tyr Leu Ser Lys Leu Pro Phe Ile Lys Val Glu Glu Asn Val Ser Val 
    370                 375                 380                 


Asp Glu Leu Arg Lys Lys Lys Pro Ile Leu Phe Ser Val Ile Met Ser 
385                 390                 395                 400 


Cys Val Ser Ile Val Leu Thr Pro Lys Gln Thr Thr Arg Gly Thr Ile 
                405                 410                 415     


Met Lys Leu Asp Ser Phe Val Leu Asn Leu Ile Thr Asn Gln Ile Phe 
            420                 425                 430         


Lys Ala Asn Asn Lys Ser Ile Glu Ile Ile Glu Ser Leu Ser Thr Leu 
        435                 440                 445             


Cys Leu Trp Tyr Asn Phe Phe Glu Trp Ser Ser Lys Thr Arg Tyr His 
    450                 455                 460                 


Ile Phe Asn Tyr Ile Cys Cys Cys Leu Thr Arg Asp Leu Gly Pro Thr 
465                 470                 475                 480 


Tyr Val Asn Arg Ser Phe Gly Met Phe Ser Asp Glu Asp Pro Lys Arg 
                485                 490                 495     


Phe Lys Ser Pro Leu Glu Leu Tyr Ser Asn Gly Ala Ser Leu Thr Leu 
            500                 505                 510         


Leu Val Tyr Ile Ser Ala Leu Asn Ile Ser Ile Phe Leu Arg Gln Ser 
        515                 520                 525             


Ile Gln Ala Arg Trp Ser His Val Thr Glu Lys Ala Cys Glu Asp Leu 
    530                 535                 540                 


Val Lys Glu Thr Lys Lys Ser Arg His Tyr Asp Asn Asp Lys Leu Leu 
545                 550                 555                 560 


Leu Asp Ser Ala Asp Asp Pro Ile Leu Val Gln Phe Ala Lys Met Asn 
                565                 570                 575     


His Val Leu Glu Asn Ile His Thr His Leu His Glu Arg Asp Leu Asn 
            580                 585                 590         


Asp Asp Glu Phe Asp Asp Pro Ile Phe Thr Lys Lys Tyr Leu Asn Lys 
        595                 600                 605             


Leu Met Glu Lys Tyr His Lys Gln Leu Gln Glu Ile Phe Thr Lys Leu 
    610                 615                 620                 


Asp Arg Asn Arg Pro Arg Val Ile Ala Phe Tyr Tyr Ser Val Glu Ala 
625                 630                 635                 640 


Tyr Leu Tyr Gln Tyr Lys Leu Ala Val Phe Ile Gly Glu Met Ser His 
                645                 650                 655     


Thr Ile Asn Glu Lys Val Glu Leu Pro Arg Glu Ile Met Asp Asp Phe 
            660                 665                 670         


Val Lys Cys Tyr His Cys Cys Lys Ser Ala Leu Glu Glu Phe Ser Lys 
        675                 680                 685             


Leu Glu Pro Ile Leu Ile Thr Ser Leu Pro Leu Phe His Thr Ser Arg 
    690                 695                 700                 


Ile Ile Tyr Thr Val Gly Met Leu Leu Leu Lys Leu Arg Tyr Ser Val 
705                 710                 715                 720 


Val Ala Ile Pro Ser Phe His Asp Leu Met Pro Leu Thr Asp Asp Ala 
                725                 730                 735     


Ile Ala Leu Val Ile Gly Val Asn Asn Leu Leu Glu Lys Thr Ser Glu 
            740                 745                 750         


Leu Tyr Pro Phe Asn Asn Ser Leu Tyr Lys Phe Arg Tyr Val Ile Ala 
        755                 760                 765             


Leu Phe Cys Gln Thr Tyr Ala Asn Lys Val Ile Asp Val Ala Asp Arg 
    770                 775                 780                 


Tyr Asn Ala Glu Arg Glu Lys Leu Lys Glu Lys Gln Val Ile Asp Glu 
785                 790                 795                 800 


Val Ser Asn Gly His Asp Gly Thr Lys Pro Ile Asn Ala Tyr Val Thr 
                805                 810                 815     


Glu Ser Gln Lys Met Pro Thr Glu Glu Asp Pro Ile Ile Asp Asn Asn 
            820                 825                 830         


Thr Asn Gln Asn Ile Thr Ala Val Pro Asp Glu Met Leu Pro Val Tyr 
        835                 840                 845             


Ser Arg Val Arg Asp Asp Thr Ala Ala Met Asn Leu Asn Ile Asn Ser 
    850                 855                 860                 


Thr Ser Tyr Met Asn Glu Ser Pro His Glu His Arg Glu Ser Met Thr 
865                 870                 875                 880 


Gly Thr Thr Leu Leu Pro Pro Pro Phe Ile Ser Asn Asp Val Thr Asn 
                885                 890                 895     


Ser Ala Asp Ser Thr Asn Ile Lys Pro Ser Pro Ser Ser Ser Val Asp 
            900                 905                 910         


Asn Leu Asn Asp Tyr Leu Thr Asp Ile Asn Ser Leu Ala Trp Gly Val 
        915                 920                 925             


Asn Ser Leu Asn Asp Glu Phe Trp Thr Asp Leu Phe Met Asn Asp Ile 
    930                 935                 940                 


<210>  24
<211>  1517
<212>  PRT
<213>  Kluyveromyces marxianus

<400>  24

Met Ser Asn Ser Ser Ser Ser Glu Gly Lys Thr Asn Glu Asp Gly Arg 
1               5                   10                  15      


Asn Ser Val His Ser Ser Asp Ser Phe Ala Gln Ser Val Ala Ser Phe 
            20                  25                  30          


His Leu Asp Asp Asn Glu Ser Gln Asn Val Thr Ala Gln Leu Ser Gln 
        35                  40                  45              


Gln Ile Thr Asn Val Leu Ser Asn Ser Asn Gly Ala Glu Arg Ile Glu 
    50                  55                  60                  


Ser Leu Ala Arg Val Ile Ser Thr Lys Thr Lys Lys Gln Met Glu Ser 
65                  70                  75                  80  


Phe Glu Val Asn Gln Leu Asp Phe Asp Leu Lys Ala Leu Leu Asn Tyr 
                85                  90                  95      


Leu Arg Ser Ser Gln Leu Glu Gln Gly Ile Glu Pro Gly Asp Ser Gly 
            100                 105                 110         


Ile Ala Phe His Asp Leu Thr Ala Val Gly Ile Asp Ala Ser Ala Ala 
        115                 120                 125             


Phe Gly Pro Ser Val Glu Glu Met Val Arg Ser Trp Ile His Phe Pro 
    130                 135                 140                 


Val Arg Leu Trp Lys Lys Ile Cys Arg Gln Lys Ser Glu Thr Pro Leu 
145                 150                 155                 160 


Arg Asn Ile Ile Gln His Cys Thr Gly Val Val Glu Ser Gly Glu Met 
                165                 170                 175     


Leu Phe Val Val Gly Arg Pro Gly Ala Gly Cys Ser Thr Leu Leu Lys 
            180                 185                 190         


Cys Leu Ser Gly Glu Thr Gly Glu Leu Val Glu Val Thr Gly Asp Ile 
        195                 200                 205             


Ser Tyr Asp Gly Leu Ser Gln Glu Glu Met Met Gln Lys Phe Lys Gly 
    210                 215                 220                 


Tyr Val Ile Tyr Cys Pro Glu Leu Asp Phe His Phe Pro Lys Ile Thr 
225                 230                 235                 240 


Val Lys Glu Thr Ile Asp Phe Ala Leu Lys Cys Lys Thr Pro Arg Ser 
                245                 250                 255     


Arg Ile Asp His Leu Thr Arg Ala Gln Tyr Val Asp Asn Met Arg Asp 
            260                 265                 270         


Leu Trp Cys Thr Val Phe Gly Leu Thr His Thr Tyr Ala Thr Asn Val 
        275                 280                 285             


Gly Asn Asp Val Val Arg Gly Val Ser Gly Gly Glu Arg Lys Arg Val 
    290                 295                 300                 


Ser Leu Val Glu Ala Leu Ala Met Asn Ala Ser Ile Tyr Ser Trp Asp 
305                 310                 315                 320 


Asn Ala Thr Arg Gly Leu Asp Ala Ser Thr Ala Leu Glu Phe Ala Gln 
                325                 330                 335     


Ala Ile Arg Thr Ala Thr Asn Met Met Asn Asn Ser Ala Ile Val Ala 
            340                 345                 350         


Ile Tyr Gln Ala Gly Glu Asn Ile Tyr Gln Leu Phe Asp Lys Thr Thr 
        355                 360                 365             


Val Leu Tyr Asn Gly Lys Gln Val Tyr Phe Gly Pro Ala Asp Glu Ala 
    370                 375                 380                 


Val Gly Tyr Phe Glu Arg Met Gly Tyr Ile Lys Pro Asn Arg Met Thr 
385                 390                 395                 400 


Ser Ala Glu Phe Leu Thr Ser Ala Thr Val Asp Phe Glu Asn Arg Thr 
                405                 410                 415     


Leu Glu Val Arg Glu Gly Tyr Glu Glu Lys Ile Pro Lys Ser Ser Thr 
            420                 425                 430         


Glu Met Glu Ala Tyr Trp His Asn Ser Pro Glu Tyr Ala Lys Ala Thr 
        435                 440                 445             


Glu Leu Phe Asn Glu Tyr Cys Gln Ser His Pro Glu Glu Glu Thr Arg 
    450                 455                 460                 


Gln Arg Leu Glu Thr Ala Lys Lys Gln Arg Leu Gln Lys Gly Gln Arg 
465                 470                 475                 480 


Glu Lys Ser Gln Phe Val Val Thr Phe Trp Ala Gln Val Trp Tyr Cys 
                485                 490                 495     


Met Ile Arg Gly Phe Gln Arg Val Lys Gly Asp Ser Thr Tyr Thr Lys 
            500                 505                 510         


Val Tyr Leu Ser Ser Phe Leu Thr Lys Gly Leu Ile Val Gly Ser Met 
        515                 520                 525             


Phe His Lys Ile Asp Pro Lys Ser Gln Ser Thr Thr Glu Gly Ala Tyr 
    530                 535                 540                 


Ser Arg Gly Gly Leu Leu Phe Tyr Val Leu Leu Phe Ala Ala Leu Thr 
545                 550                 555                 560 


Ser Leu Ala Glu Ile Ser Asn Ser Phe Gln Asn Arg Ala Ile Ile Val 
                565                 570                 575     


Lys Gln Lys Thr Tyr Ser Met Tyr His Thr Ser Ala Glu Ser Leu Gln 
            580                 585                 590         


Glu Ile Phe Thr Glu Ile Pro Thr Lys Phe Val Ala Ile Leu Thr Leu 
        595                 600                 605             


Ser Leu Val Ser Tyr Trp Ile Pro Val Leu Lys Tyr Asp Ala Gly Ser 
    610                 615                 620                 


Phe Phe Gln Tyr Leu Leu Tyr Leu Phe Thr Thr Gln Gln Cys Thr Ser 
625                 630                 635                 640 


Phe Ile Phe Lys Leu Val Ala Thr Leu Thr Lys Asp Gly Gly Thr Ala 
                645                 650                 655     


His Ala Ile Gly Gly Leu Trp Val Leu Met Leu Thr Val Tyr Ala Gly 
            660                 665                 670         


Phe Val Leu Pro Ile Gly Asn Met His His Trp Ile Arg Trp Phe His 
        675                 680                 685             


Tyr Leu Asn Pro Leu Thr Tyr Ala Tyr Glu Ser Leu Met Ser Thr Glu 
    690                 695                 700                 


Phe His Gly Arg Lys Met Leu Cys Ser Arg Leu Leu Pro Ser Gly Pro 
705                 710                 715                 720 


Gly Tyr Glu Asn Val Ser Ile Ala His Lys Ile Cys Asp Ala Ala Gly 
                725                 730                 735     


Ala Val Ala Gly Gln Leu Tyr Val Ser Gly Asp Ala Tyr Val Leu Lys 
            740                 745                 750         


Lys Tyr His Phe Arg Tyr Lys His Ala Trp Arg Asp Trp Gly Ile Asn 
        755                 760                 765             


Ile Val Trp Thr Phe Gly Tyr Ile Val Met Asn Val Val Met Ser Glu 
    770                 775                 780                 


Tyr Leu Lys Pro Leu Glu Gly Gly Gly Asp Leu Leu Leu Tyr Lys Arg 
785                 790                 795                 800 


Gly His Met Pro Glu Leu Gly Ser Glu Ser Val Asp Ser Lys Val Ala 
                805                 810                 815     


Ser Arg Glu Glu Met Met Glu Ser Leu Asn Gly Pro Gly Val Asp Leu 
            820                 825                 830         


Glu Lys Val Ile Ala Ser Lys Asp Val Phe Thr Trp Asn His Leu Asn 
        835                 840                 845             


Tyr Thr Ile Pro Tyr Asp Gly Ala Thr Arg Gln Leu Leu Ser Asp Val 
    850                 855                 860                 


Phe Gly Tyr Val Lys Pro Gly Lys Met Thr Ala Leu Met Gly Glu Ser 
865                 870                 875                 880 


Gly Ala Gly Lys Thr Thr Leu Leu Asn Val Leu Ala Gln Arg Ile Asn 
                885                 890                 895     


Val Gly Val Ile Thr Gly Asp Met Leu Val Asn Ala Lys Pro Leu Pro 
            900                 905                 910         


Pro Ser Phe Asn Arg Ser Cys Gly Tyr Val Ala Gln Ala Asp Asn His 
        915                 920                 925             


Met Gly Glu Leu Ser Val Arg Glu Ser Leu Arg Phe Ala Ala Glu Leu 
    930                 935                 940                 


Arg Gln Pro Lys Ser Val Pro Leu Gln Glu Lys Tyr Asp Tyr Val Glu 
945                 950                 955                 960 


Lys Ile Ile Ser Leu Leu Gly Met Glu Lys Tyr Ala Glu Ala Ile Ile 
                965                 970                 975     


Gly Lys Thr Gly Arg Gly Leu Asn Val Glu Gln Arg Lys Lys Leu Ser 
            980                 985                 990         


Ile Gly Val Glu Leu Val Ala Lys  Pro Ser Leu Leu Leu  Phe Leu Asp 
        995                 1000                 1005             


Glu Pro  Thr Ser Gly Leu Asp  Ser Gln Ser Ala Trp  Ser Ile Val 
    1010                 1015                 1020             


Gln Phe  Met Arg Ala Leu Ala  Asp Ser Gly Gln Ser  Ile Leu Cys 
    1025                 1030                 1035             


Thr Ile  His Gln Pro Ser Ala  Thr Leu Phe Glu Gln  Phe Asp Arg 
    1040                 1045                 1050             


Leu Leu  Leu Leu Lys Lys Gly  Gly Lys Met Val Tyr  Phe Gly Asp 
    1055                 1060                 1065             


Ile Gly  Glu Asn Ser Ser Thr  Leu Leu Asn Tyr Phe  Glu Arg Gln 
    1070                 1075                 1080             


Ser Gly  Val Lys Cys Gly Lys  Ser Glu Asn Pro Ala  Glu Tyr Met 
    1085                 1090                 1095             


Leu Asn  Cys Ile Gly Ala Gly  Ala Thr Ala Ser Ala  Asp Ala Asp 
    1100                 1105                 1110             


Trp His  Asp Leu Trp Leu Gln  Ser Pro Glu Cys Ala  Ala Ala Arg 
    1115                 1120                 1125             


Glu Glu  Val Glu Glu Leu His  Arg Thr Leu Ala Ser  Arg Pro Val 
    1130                 1135                 1140             


Thr Asp  Asp Lys Glu Leu Ala  Gly Arg Tyr Ala Ala  Ser Tyr Leu 
    1145                 1150                 1155             


Thr Gln  Met Lys Cys Val Phe  Arg Arg Thr Asn Ile  Gln Phe Trp 
    1160                 1165                 1170             


Arg Ser  Pro Val Tyr Ile Arg  Ala Lys Phe Leu Glu  Cys Val Leu 
    1175                 1180                 1185             


Cys Ala  Leu Phe Val Gly Leu  Ser Tyr Val Gly Val  Asp His Ser 
    1190                 1195                 1200             


Ile Ala  Gly Ala Ser Gln Ser  Phe Ser Ser Ile Phe  Met Met Leu 
    1205                 1210                 1215             


Leu Ile  Ala Leu Ala Met Val  Asn Gln Leu His Val  Phe Ala Leu 
    1220                 1225                 1230             


Asp Ser  Arg Glu Leu Tyr Glu  Val Arg Glu Ala Ala  Ser Asn Thr 
    1235                 1240                 1245             


Phe His  Trp Ser Val Leu Leu  Leu Asn His Thr Phe  Val Glu Ile 
    1250                 1255                 1260             


Ile Trp  Ser Thr Leu Cys Glu  Phe Ile Cys Trp Ile  Cys Tyr Tyr 
    1265                 1270                 1275             


Trp Pro  Ala Gln Tyr Ser Gly  Arg Ala Ser His Ala  Gly Tyr Phe 
    1280                 1285                 1290             


Phe Leu  Ile Tyr Val Ile Met  Phe Pro Ala Tyr Phe  Val Ser Tyr 
    1295                 1300                 1305             


Gly Cys  Trp Val Phe Tyr Met  Ser Pro Asp Val Pro  Ser Ala Ser 
    1310                 1315                 1320             


Met Ile  Asn Ser Asn Leu Phe  Ala Gly Met Leu Leu  Phe Cys Gly 
    1325                 1330                 1335             


Ile Leu  Gln Pro Lys Asp Lys  Met Pro Gly Phe Trp  Lys Arg Phe 
    1340                 1345                 1350             


Met Tyr  Asn Val Ser Pro Phe  Thr Tyr Val Val Gln  Ser Leu Val 
    1355                 1360                 1365             


Thr Pro  Leu Val Gln Gly Lys  Lys Val Arg Cys Thr  Lys Asn Glu 
    1370                 1375                 1380             


Phe Ala  Val Val Asn Pro Pro  Glu Gly Gln Thr Cys  Ser Gln Tyr 
    1385                 1390                 1395             


Phe Ala  Arg Phe Ile Lys Asp  Asn Thr Gly Tyr Leu  Lys Asn Pro 
    1400                 1405                 1410             


Asn Asp  Thr Glu Ser Cys His  Tyr Cys Pro Tyr Ser  Tyr Gln Gln 
    1415                 1420                 1425             


Glu Val  Val Glu Gln Tyr Asn  Val Arg Trp Val Tyr  Arg Trp Arg 
    1430                 1435                 1440             


Asn Phe  Gly Phe Leu Trp Ala  Tyr Ile Gly Phe Asn  Phe Phe Ala 
    1445                 1450                 1455             


Met Leu  Ala Cys Tyr Trp Val  Leu Arg Val Lys Asn  Tyr Ser Ile 
    1460                 1465                 1470             


Thr Ser  Ile Phe Gly Val Phe  Lys Ile Gly Asn Trp  Lys Lys Ala 
    1475                 1480                 1485             


Ile His  His Asp Ser Arg His  Glu Lys Asp His Thr  Ile Phe Gln 
    1490                 1495                 1500             


Glu Lys  Pro Gly Asp Ala Ala  Asn Val Gln Lys Thr  Lys Ala 
    1505                 1510                 1515         


<210>  25
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  25

Met Ser Ser Leu Lys Pro Lys Ile Lys Ala Ile Ser Met Met Pro Lys 
1               5                   10                  15      


Leu Val Leu Val Arg His Gly Gln Ser Glu Trp Asn Glu Lys Asn Leu 
            20                  25                  30          


Phe Thr Gly Trp Val Asp Val Lys Leu Ser Ala Val Gly Glu Lys Glu 
        35                  40                  45              


Ala Ala Arg Ala Gly Glu Leu Leu Lys Glu Ala Asn Ile Lys Pro Asp 
    50                  55                  60                  


Val Leu Tyr Thr Ser Lys Leu Ser Arg Ala Ile Gln Thr Ala Asn Ile 
65                  70                  75                  80  


Ala Leu Glu Lys Ala Asp Arg Leu Trp Ile Pro Val Lys Arg Ser Trp 
                85                  90                  95      


Arg Leu Asn Glu Arg His Tyr Gly Ala Leu Gln Gly Lys Asp Lys Ala 
            100                 105                 110         


Glu Thr Leu Glu Gln Tyr Gly Glu Glu Lys Phe Gln Thr Trp Arg Arg 
        115                 120                 125             


Ser Phe Asp Val Pro Pro Pro Pro Ile Glu Asp Asp Ser Glu Phe Ser 
    130                 135                 140                 


Gln Lys Gly Asp Glu Arg Tyr Ala Asp Val Asp Pro Ala Val Leu Pro 
145                 150                 155                 160 


Lys Thr Glu Ser Leu Ala Leu Val Ile Asp Arg Leu Leu Pro Tyr Trp 
                165                 170                 175     


Gln Asp Val Ile Ala Lys Asp Leu Leu Ala Gly Lys Thr Val Leu Ile 
            180                 185                 190         


Ala Ala His Gly Asn Ser Leu Arg Ala Leu Val Lys His Leu Asp Asn 
        195                 200                 205             


Ile Ser Asp Ala Asp Ile Ala Gly Leu Asn Ile Pro Thr Gly Ile Pro 
    210                 215                 220                 


Leu Val Tyr Glu Leu Asp Glu Asn Leu Lys Pro Thr Lys Pro Ala Tyr 
225                 230                 235                 240 


Tyr Leu Asp Pro Glu Ala Ala Ala Ala Gly Ala Ala Ala Val Ala Ala 
                245                 250                 255     


Gln Gly Lys Lys Lys 
            260     


<210>  26
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  26

Met Ala Ile Ser Lys Ile His Ala Arg Ser Val Tyr Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Thr Thr Glu Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ile Val Pro Ser Gly Ala Ser Thr Gly Ile His Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Ser Lys Trp Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Ala Asn Val Asn Asp Val Ile Ala Pro Ala Leu Ile Lys Ala 
65                  70                  75                  80  


Asn Ile Asp Val Lys Asp Gln Ser Lys Val Asp Glu Phe Leu Ile Lys 
                85                  90                  95      


Leu Asp Gly Thr Pro Asn Lys Ser Lys Leu Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Ala Ala Lys Ala Ala Ala Ala Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Ala His Ile Ala Asp Leu Ala Gly Thr Lys Thr Lys Pro 
    130                 135                 140                 


Tyr Val Leu Pro Val Pro Phe Gln Asn Val Leu Asn Gly Gly Ser His 
145                 150                 155                 160 


Ala Gly Gly Ala Leu Ala Phe Gln Glu Phe Met Ile Val Pro Thr Gly 
                165                 170                 175     


Ala Pro Ser Phe Ser Glu Ala Leu Arg Ile Gly Ser Glu Val Tyr His 
            180                 185                 190         


Asn Leu Lys Ser Leu Ala Lys Lys Lys Tyr Gly Gln Ser Ala Gly Asn 
        195                 200                 205             


Val Gly Asp Glu Gly Gly Val Ala Pro Asp Ile Gln Thr Ala Glu Glu 
    210                 215                 220                 


Ala Leu Asp Leu Ile Val Asp Ala Ile Glu Ala Ala Gly Tyr Thr Gly 
225                 230                 235                 240 


Lys Val Lys Ile Ala Leu Asp Val Ala Ser Ser Glu Phe Tyr Lys Asp 
                245                 250                 255     


Asp Ala Gly Lys Tyr Asp Leu Asp Phe Lys Asn Pro Glu Ser Asp Pro 
            260                 265                 270         


Ser Lys Trp Leu Thr Gly Glu Gln Leu Ala Asp Leu Tyr His Ser Leu 
        275                 280                 285             


Ala Lys Lys Tyr Pro Ile Val Ser Ile Glu Asp Pro Phe Ala Glu Asp 
    290                 295                 300                 


Asp Trp Glu Ala Trp Ser His Phe Tyr Lys Thr Ala Gly Ser Asp Ile 
305                 310                 315                 320 


Gln Ile Val Gly Asp Asp Leu Thr Val Thr Asn Pro Ile Arg Ile Lys 
                325                 330                 335     


Thr Ala Ile Glu Lys Lys Ala Ala Asn Ala Leu Leu Leu Lys Val Asn 
            340                 345                 350         


Gln Ile Gly Thr Leu Thr Glu Ser Ile Gln Ala Ala Lys Asp Ser Tyr 
        355                 360                 365             


Ala Ala Gly Trp Gly Val Met Val Ser His Arg Ser Gly Glu Thr Glu 
    370                 375                 380                 


Asp Thr Phe Ile Ala Asp Leu Val Val Gly Leu Arg Thr Gly Gln Ile 
385                 390                 395                 400 


Lys Thr Gly Ala Pro Ala Arg Ser Glu Arg Leu Ala Lys Leu Asn Gln 
                405                 410                 415     


Ile Leu Arg Ile Glu Glu Glu Leu Gly Asp Lys Ala Ile Tyr Ala Gly 
            420                 425                 430         


Glu Asn Phe His Thr Ala Val Asn Leu 
        435                 440     


<210>  27
<211>  438
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  27

Met Gly Glu Leu Lys Glu Ile Leu Lys Gln Arg Tyr His Glu Leu Leu 
1               5                   10                  15      


Asp Trp Asn Val Lys Ala Pro His Val Pro Leu Ser Gln Arg Leu Lys 
            20                  25                  30          


His Phe Thr Trp Ser Trp Phe Ala Cys Thr Met Ala Thr Gly Gly Val 
        35                  40                  45              


Gly Leu Ile Ile Gly Ser Phe Pro Phe Arg Phe Tyr Gly Leu Asn Thr 
    50                  55                  60                  


Ile Gly Lys Ile Val Tyr Ile Leu Gln Ile Phe Leu Phe Ser Leu Phe 
65                  70                  75                  80  


Gly Ser Cys Met Leu Phe Arg Phe Ile Lys Tyr Pro Ser Thr Ile Lys 
                85                  90                  95      


Asp Ser Trp Asn His His Leu Glu Lys Leu Phe Ile Ala Thr Cys Leu 
            100                 105                 110         


Leu Ser Ile Ser Thr Phe Ile Asp Met Leu Ala Ile Tyr Ala Tyr Pro 
        115                 120                 125             


Asp Thr Gly Glu Trp Met Val Trp Val Ile Arg Ile Leu Tyr Tyr Ile 
    130                 135                 140                 


Tyr Val Ala Val Ser Phe Ile Tyr Cys Val Met Ala Phe Phe Thr Ile 
145                 150                 155                 160 


Phe Asn Asn His Val Tyr Thr Ile Glu Thr Ala Ser Pro Ala Trp Ile 
                165                 170                 175     


Leu Pro Ile Phe Pro Pro Met Ile Cys Gly Val Ile Ala Gly Ala Val 
            180                 185                 190         


Asn Ser Thr Gln Pro Ala His Gln Leu Lys Asn Met Val Ile Phe Gly 
        195                 200                 205             


Ile Leu Phe Gln Gly Leu Gly Phe Trp Val Tyr Leu Leu Leu Phe Ala 
    210                 215                 220                 


Val Asn Val Leu Arg Phe Phe Thr Val Gly Leu Ala Lys Pro Gln Asp 
225                 230                 235                 240 


Arg Pro Gly Met Phe Met Phe Val Gly Pro Pro Ala Phe Ser Gly Leu 
                245                 250                 255     


Ala Leu Ile Asn Ile Ala Arg Gly Ala Met Gly Ser Arg Pro Tyr Ile 
            260                 265                 270         


Phe Val Gly Ala Asn Ser Ser Glu Tyr Leu Gly Phe Val Ser Thr Phe 
        275                 280                 285             


Met Ala Ile Phe Ile Trp Gly Leu Ala Ala Trp Cys Tyr Cys Leu Ala 
    290                 295                 300                 


Met Val Ser Phe Leu Ala Gly Phe Phe Thr Arg Ala Pro Leu Lys Phe 
305                 310                 315                 320 


Ala Cys Gly Trp Phe Ala Phe Ile Phe Pro Asn Val Gly Phe Val Asn 
                325                 330                 335     


Cys Thr Ile Glu Ile Gly Lys Met Ile Asp Ser Lys Ala Phe Gln Met 
            340                 345                 350         


Phe Gly His Ile Ile Gly Val Ile Leu Cys Ile Gln Trp Ile Leu Leu 
        355                 360                 365             


Met Tyr Leu Met Val Arg Ala Phe Leu Val Asn Asp Leu Cys Tyr Pro 
    370                 375                 380                 


Gly Lys Asp Glu Asp Ala His Pro Pro Pro Lys Pro Asn Thr Gly Val 
385                 390                 395                 400 


Leu Asn Pro Thr Phe Pro Pro Glu Lys Ala Pro Ala Ser Leu Glu Lys 
                405                 410                 415     


Val Asp Thr His Val Thr Ser Thr Gly Gly Glu Ser Asp Pro Pro Ser 
            420                 425                 430         


Ser Glu His Glu Ser Val 
        435             


<210>  28
<211>  437
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  28

Met Ala Val Ser Lys Val Tyr Ala Arg Ser Val Tyr Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Glu Leu Thr Thr Glu Lys Gly Val Phe Arg 
            20                  25                  30          


Ser Ile Val Pro Ser Gly Ala Ser Thr Gly Val His Glu Ala Leu Glu 
        35                  40                  45              


Met Arg Asp Gly Asp Lys Ser Lys Trp Met Gly Lys Gly Val Leu His 
    50                  55                  60                  


Ala Val Lys Asn Val Asn Asp Val Ile Ala Pro Ala Phe Val Lys Ala 
65                  70                  75                  80  


Asn Ile Asp Val Lys Asp Gln Lys Ala Val Asp Asp Phe Leu Ile Ser 
                85                  90                  95      


Leu Asp Gly Thr Ala Asn Lys Ser Lys Leu Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Ala Ser Arg Ala Ala Ala Ala Glu Lys Asn Val 
        115                 120                 125             


Pro Leu Tyr Lys His Leu Ala Asp Leu Ser Lys Ser Lys Thr Ser Pro 
    130                 135                 140                 


Tyr Val Leu Pro Val Pro Phe Leu Asn Val Leu Asn Gly Gly Ser His 
145                 150                 155                 160 


Ala Gly Gly Ala Leu Ala Leu Gln Glu Phe Met Ile Ala Pro Thr Gly 
                165                 170                 175     


Ala Lys Thr Phe Ala Glu Ala Leu Arg Ile Gly Ser Glu Val Tyr His 
            180                 185                 190         


Asn Leu Lys Ser Leu Thr Lys Lys Arg Tyr Gly Ala Ser Ala Gly Asn 
        195                 200                 205             


Val Gly Asp Glu Gly Gly Val Ala Pro Asn Ile Gln Thr Ala Glu Glu 
    210                 215                 220                 


Ala Leu Asp Leu Ile Val Asp Ala Ile Lys Ala Ala Gly His Asp Gly 
225                 230                 235                 240 


Lys Ile Lys Ile Gly Leu Asp Cys Ala Ser Ser Glu Phe Phe Lys Asp 
                245                 250                 255     


Gly Lys Tyr Asp Leu Asp Phe Lys Asn Pro Asn Ser Asp Lys Ser Lys 
            260                 265                 270         


Trp Leu Thr Gly Pro Gln Leu Ala Asp Leu Tyr His Ser Leu Met Lys 
        275                 280                 285             


Arg Tyr Pro Ile Val Ser Ile Glu Asp Pro Phe Ala Glu Asp Asp Trp 
    290                 295                 300                 


Glu Ala Trp Ser His Phe Phe Lys Thr Ala Gly Ile Gln Ile Val Ala 
305                 310                 315                 320 


Asp Asp Leu Thr Val Thr Asn Pro Lys Arg Ile Ala Thr Ala Ile Glu 
                325                 330                 335     


Lys Lys Ala Ala Asp Ala Leu Leu Leu Lys Val Asn Gln Ile Gly Thr 
            340                 345                 350         


Leu Ser Glu Ser Ile Lys Ala Ala Gln Asp Ser Phe Ala Ala Gly Trp 
        355                 360                 365             


Gly Val Met Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile 
    370                 375                 380                 


Ala Asp Leu Val Val Gly Leu Arg Thr Gly Gln Ile Lys Thr Gly Ala 
385                 390                 395                 400 


Pro Ala Arg Ser Glu Arg Leu Ala Lys Leu Asn Gln Leu Leu Arg Ile 
                405                 410                 415     


Glu Glu Glu Leu Gly Asp Asn Ala Val Phe Ala Gly Glu Asn Phe His 
            420                 425                 430         


His Gly Asp Lys Leu 
        435         


<210>  29
<211>  437
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  29

Met Ala Val Ser Lys Val Tyr Ala Arg Ser Val Tyr Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Glu Leu Thr Thr Glu Lys Gly Val Phe Arg 
            20                  25                  30          


Ser Ile Val Pro Ser Gly Ala Ser Thr Gly Val His Glu Ala Leu Glu 
        35                  40                  45              


Met Arg Asp Glu Asp Lys Ser Lys Trp Met Gly Lys Gly Val Met Asn 
    50                  55                  60                  


Ala Val Asn Asn Val Asn Asn Val Ile Ala Ala Ala Phe Val Lys Ala 
65                  70                  75                  80  


Asn Leu Asp Val Lys Asp Gln Lys Ala Val Asp Asp Phe Leu Leu Ser 
                85                  90                  95      


Leu Asp Gly Thr Ala Asn Lys Ser Lys Leu Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Met Ala Ala Ala Arg Ala Ala Ala Ala Glu Lys Asn Val 
        115                 120                 125             


Pro Leu Tyr Gln His Leu Ala Asp Leu Ser Lys Ser Lys Thr Ser Pro 
    130                 135                 140                 


Tyr Val Leu Pro Val Pro Phe Leu Asn Val Leu Asn Gly Gly Ser His 
145                 150                 155                 160 


Ala Gly Gly Ala Leu Ala Leu Gln Glu Phe Met Ile Ala Pro Thr Gly 
                165                 170                 175     


Ala Lys Thr Phe Ala Glu Ala Met Arg Ile Gly Ser Glu Val Tyr His 
            180                 185                 190         


Asn Leu Lys Ser Leu Thr Lys Lys Arg Tyr Gly Ala Ser Ala Gly Asn 
        195                 200                 205             


Val Gly Asp Glu Gly Gly Val Ala Pro Asn Ile Gln Thr Ala Glu Glu 
    210                 215                 220                 


Ala Leu Asp Leu Ile Val Asp Ala Ile Lys Ala Ala Gly His Asp Gly 
225                 230                 235                 240 


Lys Val Lys Ile Gly Leu Asp Cys Ala Ser Ser Glu Phe Phe Lys Asp 
                245                 250                 255     


Gly Lys Tyr Asp Leu Asp Phe Lys Asn Pro Glu Ser Asp Lys Ser Lys 
            260                 265                 270         


Trp Leu Thr Gly Val Glu Leu Ala Asp Met Tyr His Ser Leu Met Lys 
        275                 280                 285             


Arg Tyr Pro Ile Val Ser Ile Glu Asp Pro Phe Ala Glu Asp Asp Trp 
    290                 295                 300                 


Glu Ala Trp Ser His Phe Phe Lys Thr Ala Gly Ile Gln Ile Val Ala 
305                 310                 315                 320 


Asp Asp Leu Thr Val Thr Asn Pro Ala Arg Ile Ala Thr Ala Ile Glu 
                325                 330                 335     


Lys Lys Ala Ala Asp Ala Leu Leu Leu Lys Val Asn Gln Ile Gly Thr 
            340                 345                 350         


Leu Ser Glu Ser Ile Lys Ala Ala Gln Asp Ser Phe Ala Ala Asn Trp 
        355                 360                 365             


Gly Val Met Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile 
    370                 375                 380                 


Ala Asp Leu Val Val Gly Leu Arg Thr Gly Gln Ile Lys Thr Gly Ala 
385                 390                 395                 400 


Pro Ala Arg Ser Glu Arg Leu Ala Lys Leu Asn Gln Leu Leu Arg Ile 
                405                 410                 415     


Glu Glu Glu Leu Gly Asp Lys Ala Val Tyr Ala Gly Glu Asn Phe His 
            420                 425                 430         


His Gly Asp Lys Leu 
        435         


<210>  30
<211>  479
<212>  PRT
<213>  Escherichia coli

<400>  30

Met Ser Val Pro Val Gln His Pro Met Tyr Ile Asp Gly Gln Phe Val 
1               5                   10                  15      


Thr Trp Arg Gly Asp Ala Trp Ile Asp Val Val Asn Pro Ala Thr Glu 
            20                  25                  30          


Ala Val Ile Ser Arg Ile Pro Asp Gly Gln Ala Glu Asp Ala Arg Lys 
        35                  40                  45              


Ala Ile Asp Ala Ala Glu Arg Ala Gln Pro Glu Trp Glu Ala Leu Pro 
    50                  55                  60                  


Ala Ile Glu Arg Ala Ser Trp Leu Arg Lys Ile Ser Ala Gly Ile Arg 
65                  70                  75                  80  


Glu Arg Ala Ser Glu Ile Ser Ala Leu Ile Val Glu Glu Gly Gly Lys 
                85                  90                  95      


Ile Gln Gln Leu Ala Glu Val Glu Val Ala Phe Thr Ala Asp Tyr Ile 
            100                 105                 110         


Asp Tyr Met Ala Glu Trp Ala Arg Arg Tyr Glu Gly Glu Ile Ile Gln 
        115                 120                 125             


Ser Asp Arg Pro Gly Glu Asn Ile Leu Leu Phe Lys Arg Ala Leu Gly 
    130                 135                 140                 


Val Thr Thr Gly Ile Leu Pro Trp Asn Phe Pro Phe Phe Leu Ile Ala 
145                 150                 155                 160 


Arg Lys Met Ala Pro Ala Leu Leu Thr Gly Asn Thr Ile Val Ile Lys 
                165                 170                 175     


Pro Ser Glu Phe Thr Pro Asn Asn Ala Ile Ala Phe Ala Lys Ile Val 
            180                 185                 190         


Asp Glu Ile Gly Leu Pro Arg Gly Val Phe Asn Leu Val Leu Gly Arg 
        195                 200                 205             


Gly Glu Thr Val Gly Gln Glu Leu Ala Gly Asn Pro Lys Val Ala Met 
    210                 215                 220                 


Val Ser Met Thr Gly Ser Val Ser Ala Gly Glu Lys Ile Met Ala Thr 
225                 230                 235                 240 


Ala Ala Lys Asn Ile Thr Lys Val Cys Leu Glu Leu Gly Gly Lys Ala 
                245                 250                 255     


Pro Ala Ile Val Met Asp Asp Ala Asp Leu Glu Leu Ala Val Lys Ala 
            260                 265                 270         


Ile Val Asp Ser Arg Val Ile Asn Ser Gly Gln Val Cys Asn Cys Ala 
        275                 280                 285             


Glu Arg Val Tyr Val Gln Lys Gly Ile Tyr Asp Gln Phe Val Asn Arg 
    290                 295                 300                 


Leu Gly Glu Ala Met Gln Ala Val Gln Phe Gly Asn Pro Ala Glu Arg 
305                 310                 315                 320 


Asn Asp Ile Ala Met Gly Pro Leu Ile Asn Ala Ala Ala Leu Glu Arg 
                325                 330                 335     


Val Glu Gln Lys Val Ala Arg Ala Val Glu Glu Gly Ala Arg Val Ala 
            340                 345                 350         


Phe Gly Gly Lys Ala Val Glu Gly Lys Gly Tyr Tyr Tyr Pro Pro Thr 
        355                 360                 365             


Leu Leu Leu Asp Val Arg Gln Glu Met Ser Ile Met His Glu Glu Thr 
    370                 375                 380                 


Phe Gly Pro Val Leu Pro Val Val Ala Phe Asp Thr Leu Glu Asp Ala 
385                 390                 395                 400 


Ile Ser Met Ala Asn Asp Ser Asp Tyr Gly Leu Thr Ser Ser Ile Tyr 
                405                 410                 415     


Thr Gln Asn Leu Asn Val Ala Met Lys Ala Ile Lys Gly Leu Lys Phe 
            420                 425                 430         


Gly Glu Thr Tyr Ile Asn Arg Glu Asn Phe Glu Ala Met Gln Gly Phe 
        435                 440                 445             


His Ala Gly Trp Arg Lys Ser Gly Ile Gly Gly Ala Asp Gly Lys His 
    450                 455                 460                 


Gly Leu His Glu Tyr Leu Gln Thr Gln Val Val Tyr Leu Gln Ser 
465                 470                 475                 


