                         SEQUENCE LISTING

<110>  ShanghaiTech University
 
<120>  FUSION PROTEINS FOR BASE EDITING

<130>  P19400563W

<150>  PCT/CN2018/076991
<151>  2018-02-23

<150>  PCT/CN2018/100411
<151>  2018-08-14

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  2
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Phe Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  3
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Asp Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  4
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Ala Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  5
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Tyr Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  6
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Lys Thr Tyr Leu Cys 
1               5                   10                  15      


Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met Asp Gln 
            20                  25                  30          


His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe 
        35                  40                  45              


Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro Ser Leu 
    50                  55                  60                  


Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp 
65                  70                  75                  80  


Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala Phe Leu 
                85                  90                  95      


Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr 
            100                 105                 110         


Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala 
        115                 120                 125             


Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His Cys Trp 
    130                 135                 140                 


Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly 
145                 150                 155                 160 


Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu 
                165                 170                 175     


Gln Asn Gln Gly Asn 
            180     


<210>  7
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Lys Thr Tyr Leu Cys 
1               5                   10                  15      


Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met Asp Gln 
            20                  25                  30          


His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe 
        35                  40                  45              


Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro Ser Leu 
    50                  55                  60                  


Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp 
65                  70                  75                  80  


Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala Phe Leu 
                85                  90                  95      


Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Phe 
            100                 105                 110         


Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala 
        115                 120                 125             


Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His Cys Trp 
    130                 135                 140                 


Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly 
145                 150                 155                 160 


Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu 
                165                 170                 175     


Gln Asn Gln Gly Asn 
            180     


<210>  8
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Lys Thr Tyr Leu Cys 
1               5                   10                  15      


Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met Asp Gln 
            20                  25                  30          


His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe 
        35                  40                  45              


Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro Ser Leu 
    50                  55                  60                  


Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp 
65                  70                  75                  80  


Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala Phe Leu 
                85                  90                  95      


Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr 
            100                 105                 110         


Asp Asp Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala 
        115                 120                 125             


Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His Cys Trp 
    130                 135                 140                 


Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly 
145                 150                 155                 160 


Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu 
                165                 170                 175     


Gln Asn Gln Gly Asn 
            180     


<210>  9
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Lys Thr Tyr Leu Cys 
1               5                   10                  15      


Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met Asp Gln 
            20                  25                  30          


His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe 
        35                  40                  45              


Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro Ser Leu 
    50                  55                  60                  


Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp 
65                  70                  75                  80  


Ser Pro Cys Phe Ser Ala Gly Cys Ala Gly Glu Val Arg Ala Phe Leu 
                85                  90                  95      


Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr 
            100                 105                 110         


Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala 
        115                 120                 125             


Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His Cys Trp 
    130                 135                 140                 


Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly 
145                 150                 155                 160 


Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu 
                165                 170                 175     


Gln Asn Gln Gly Asn 
            180     


<210>  10
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Lys Thr Tyr Leu Cys 
1               5                   10                  15      


Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met Asp Gln 
            20                  25                  30          


His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe 
        35                  40                  45              


Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro Ser Leu 
    50                  55                  60                  


Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp 
65                  70                  75                  80  


Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala Phe Leu 
                85                  90                  95      


Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr 
            100                 105                 110         


Tyr Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala 
        115                 120                 125             


Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His Cys Trp 
    130                 135                 140                 


Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly 
145                 150                 155                 160 


Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu 
                165                 170                 175     


Gln Asn Gln Gly Asn 
            180     


<210>  11
<211>  1399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Pro Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val Glu Ala Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
            20                  25                  30          


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
        35                  40                  45              


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
    50                  55                  60                  


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
65                  70                  75                  80  


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
                85                  90                  95      


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
            100                 105                 110         


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
        115                 120                 125             


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
    130                 135                 140                 


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
145                 150                 155                 160 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
                165                 170                 175     


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
            180                 185                 190         


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
        195                 200                 205             


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
    210                 215                 220                 


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
225                 230                 235                 240 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
                245                 250                 255     


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
            260                 265                 270         


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
        275                 280                 285             


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
    290                 295                 300                 


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
305                 310                 315                 320 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
                325                 330                 335     


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
            340                 345                 350         


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
        355                 360                 365             


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
    370                 375                 380                 


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
385                 390                 395                 400 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
                405                 410                 415     


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
            420                 425                 430         


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
        435                 440                 445             


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
    450                 455                 460                 


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
465                 470                 475                 480 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
                485                 490                 495     


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
            500                 505                 510         


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
        515                 520                 525             


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
    530                 535                 540                 


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
545                 550                 555                 560 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
                565                 570                 575     


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
            580                 585                 590         


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
        595                 600                 605             


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
    610                 615                 620                 


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
625                 630                 635                 640 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
                645                 650                 655     


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
            660                 665                 670         


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
        675                 680                 685             


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
    690                 695                 700                 


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
705                 710                 715                 720 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
                725                 730                 735     


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
            740                 745                 750         


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
        755                 760                 765             


Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala 
    770                 775                 780                 


Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg 
785                 790                 795                 800 


Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu 
                805                 810                 815     


Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr 
            820                 825                 830         


Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu 
        835                 840                 845             


Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln 
    850                 855                 860                 


Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser 
865                 870                 875                 880 


Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val 
                885                 890                 895     


Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile 
            900                 905                 910         


Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu 
        915                 920                 925             


Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr 
    930                 935                 940                 


Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn 
945                 950                 955                 960 


Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile 
                965                 970                 975     


Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe 
            980                 985                 990         


Tyr Lys Val Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
        995                 1000                 1005             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1010                 1015                 1020             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1025                 1030                 1035             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1040                 1045                 1050             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1055                 1060                 1065             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1070                 1075                 1080             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1085                 1090                 1095             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1100                 1105                 1110             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1115                 1120                 1125             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1130                 1135                 1140             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1145                 1150                 1155             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1160                 1165                 1170             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1175                 1180                 1185             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1190                 1195                 1200             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1205                 1210                 1215             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1220                 1225                 1230             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1235                 1240                 1245             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1250                 1255                 1260             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1265                 1270                 1275             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1280                 1285                 1290             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1295                 1300                 1305             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1310                 1315                 1320             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1325                 1330                 1335             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1340                 1345                 1350             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1370                 1375                 1380             


Gln Leu  Gly Gly Asp Ser Pro  Lys Lys Lys Arg Lys  Val Glu Ala 
    1385                 1390                 1395             


Ser 
    


<210>  12
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Thr Asn Leu Ser Asp Ile Ile Glu Lys Glu Thr Gly Lys Gln Leu Val 
1               5                   10                  15      


Ile Gln Glu Ser Ile Leu Met Leu Pro Glu Glu Val Glu Glu Val Ile 
            20                  25                  30          


Gly Asn Lys Pro Glu Ser Asp Ile Leu Val His Thr Ala Tyr Asp Glu 
        35                  40                  45              


Ser Thr Asp Glu Asn Val Met Leu Leu Thr Ser Asp Ala Pro Glu Tyr 
    50                  55                  60                  


Lys Pro Trp Ala Leu Val Ile Gln Asp Ser Asn Gly Glu Asn Lys Ile 
65                  70                  75                  80  


Lys Met Leu 
            


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Ser Gly Gly Ser 
1               


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  16
<211>  1680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
    210                 215                 220                 


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
225                 230                 235                 240 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
                245                 250                 255     


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
            260                 265                 270         


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
        275                 280                 285             


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
    290                 295                 300                 


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
305                 310                 315                 320 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
                325                 330                 335     


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
            340                 345                 350         


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
        355                 360                 365             


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
    370                 375                 380                 


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
385                 390                 395                 400 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
                405                 410                 415     


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
            420                 425                 430         


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
        435                 440                 445             


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
    450                 455                 460                 


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
465                 470                 475                 480 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
                485                 490                 495     


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
            500                 505                 510         


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
        515                 520                 525             


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
    530                 535                 540                 


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
545                 550                 555                 560 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
                565                 570                 575     


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
            580                 585                 590         


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
        595                 600                 605             


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
    610                 615                 620                 


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
625                 630                 635                 640 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
                645                 650                 655     


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
            660                 665                 670         


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
        675                 680                 685             


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
    690                 695                 700                 


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
705                 710                 715                 720 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
                725                 730                 735     


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
            740                 745                 750         


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
        755                 760                 765             


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
    770                 775                 780                 


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
785                 790                 795                 800 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
                805                 810                 815     


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
            820                 825                 830         


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
        835                 840                 845             


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
    850                 855                 860                 


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
865                 870                 875                 880 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
                885                 890                 895     


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
            900                 905                 910         


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
        915                 920                 925             


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
    930                 935                 940                 


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
945                 950                 955                 960 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
                965                 970                 975     


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
            980                 985                 990         


Glu Arg Met Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
        995                 1000                 1005             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1010                 1015                 1020             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1025                 1030                 1035             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1040                 1045                 1050             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1055                 1060                 1065             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1070                 1075                 1080             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1085                 1090                 1095             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1100                 1105                 1110             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1115                 1120                 1125             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1130                 1135                 1140             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1145                 1150                 1155             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1160                 1165                 1170             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1175                 1180                 1185             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1190                 1195                 1200             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1205                 1210                 1215             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1220                 1225                 1230             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1235                 1240                 1245             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1250                 1255                 1260             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1265                 1270                 1275             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1280                 1285                 1290             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1295                 1300                 1305             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1310                 1315                 1320             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1325                 1330                 1335             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1340                 1345                 1350             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1355                 1360                 1365             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1370                 1375                 1380             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1385                 1390                 1395             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1400                 1405                 1410             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1415                 1420                 1425             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1430                 1435                 1440             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1445                 1450                 1455             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1460                 1465                 1470             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1475                 1480                 1485             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1490                 1495                 1500             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1505                 1510                 1515             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1520                 1525                 1530             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1535                 1540                 1545             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1550                 1555                 1560             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1565                 1570                 1575             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1580                 1585                 1590             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1595                 1600                 1605             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1610                 1615                 1620             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1625                 1630                 1635             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1640                 1645                 1650             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1655                 1660                 1665             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1670                 1675                 1680 


<210>  17
<211>  1680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Phe Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
    210                 215                 220                 


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
225                 230                 235                 240 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
                245                 250                 255     


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
            260                 265                 270         


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
        275                 280                 285             


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
    290                 295                 300                 


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
305                 310                 315                 320 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
                325                 330                 335     


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
            340                 345                 350         


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
        355                 360                 365             


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
    370                 375                 380                 


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
385                 390                 395                 400 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
                405                 410                 415     


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
            420                 425                 430         


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
        435                 440                 445             


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
    450                 455                 460                 


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
465                 470                 475                 480 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
                485                 490                 495     


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
            500                 505                 510         


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
        515                 520                 525             


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
    530                 535                 540                 


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
545                 550                 555                 560 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
                565                 570                 575     


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
            580                 585                 590         


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
        595                 600                 605             


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
    610                 615                 620                 


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
625                 630                 635                 640 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
                645                 650                 655     


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
            660                 665                 670         


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
        675                 680                 685             


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
    690                 695                 700                 


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
705                 710                 715                 720 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
                725                 730                 735     


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
            740                 745                 750         


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
        755                 760                 765             


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
    770                 775                 780                 


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
785                 790                 795                 800 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
                805                 810                 815     


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
            820                 825                 830         


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
        835                 840                 845             


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
    850                 855                 860                 


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
865                 870                 875                 880 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
                885                 890                 895     


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
            900                 905                 910         


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
        915                 920                 925             


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
    930                 935                 940                 


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
945                 950                 955                 960 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
                965                 970                 975     


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
            980                 985                 990         


Glu Arg Met Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
        995                 1000                 1005             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1010                 1015                 1020             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1025                 1030                 1035             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1040                 1045                 1050             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1055                 1060                 1065             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1070                 1075                 1080             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1085                 1090                 1095             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1100                 1105                 1110             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1115                 1120                 1125             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1130                 1135                 1140             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1145                 1150                 1155             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1160                 1165                 1170             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1175                 1180                 1185             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1190                 1195                 1200             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1205                 1210                 1215             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1220                 1225                 1230             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1235                 1240                 1245             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1250                 1255                 1260             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1265                 1270                 1275             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1280                 1285                 1290             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1295                 1300                 1305             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1310                 1315                 1320             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1325                 1330                 1335             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1340                 1345                 1350             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1355                 1360                 1365             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1370                 1375                 1380             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1385                 1390                 1395             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1400                 1405                 1410             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1415                 1420                 1425             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1430                 1435                 1440             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1445                 1450                 1455             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1460                 1465                 1470             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1475                 1480                 1485             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1490                 1495                 1500             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1505                 1510                 1515             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1520                 1525                 1530             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1535                 1540                 1545             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1550                 1555                 1560             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1565                 1570                 1575             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1580                 1585                 1590             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1595                 1600                 1605             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1610                 1615                 1620             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1625                 1630                 1635             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1640                 1645                 1650             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1655                 1660                 1665             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1670                 1675                 1680 


<210>  18
<211>  1680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Asp Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
    210                 215                 220                 


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
225                 230                 235                 240 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
                245                 250                 255     


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
            260                 265                 270         


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
        275                 280                 285             


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
    290                 295                 300                 


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
305                 310                 315                 320 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
                325                 330                 335     


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
            340                 345                 350         


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
        355                 360                 365             


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
    370                 375                 380                 


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
385                 390                 395                 400 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
                405                 410                 415     


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
            420                 425                 430         


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
        435                 440                 445             


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
    450                 455                 460                 


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
465                 470                 475                 480 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
                485                 490                 495     


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
            500                 505                 510         


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
        515                 520                 525             


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
    530                 535                 540                 


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
545                 550                 555                 560 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
                565                 570                 575     


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
            580                 585                 590         


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
        595                 600                 605             


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
    610                 615                 620                 


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
625                 630                 635                 640 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
                645                 650                 655     


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
            660                 665                 670         


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
        675                 680                 685             


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
    690                 695                 700                 


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
705                 710                 715                 720 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
                725                 730                 735     


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
            740                 745                 750         


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
        755                 760                 765             


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
    770                 775                 780                 


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
785                 790                 795                 800 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
                805                 810                 815     


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
            820                 825                 830         


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
        835                 840                 845             


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
    850                 855                 860                 


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
865                 870                 875                 880 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
                885                 890                 895     


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
            900                 905                 910         


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
        915                 920                 925             


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
    930                 935                 940                 


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
945                 950                 955                 960 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
                965                 970                 975     


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
            980                 985                 990         


Glu Arg Met Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
        995                 1000                 1005             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1010                 1015                 1020             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1025                 1030                 1035             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1040                 1045                 1050             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1055                 1060                 1065             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1070                 1075                 1080             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1085                 1090                 1095             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1100                 1105                 1110             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1115                 1120                 1125             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1130                 1135                 1140             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1145                 1150                 1155             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1160                 1165                 1170             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1175                 1180                 1185             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1190                 1195                 1200             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1205                 1210                 1215             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1220                 1225                 1230             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1235                 1240                 1245             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1250                 1255                 1260             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1265                 1270                 1275             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1280                 1285                 1290             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1295                 1300                 1305             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1310                 1315                 1320             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1325                 1330                 1335             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1340                 1345                 1350             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1355                 1360                 1365             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1370                 1375                 1380             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1385                 1390                 1395             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1400                 1405                 1410             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1415                 1420                 1425             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1430                 1435                 1440             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1445                 1450                 1455             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1460                 1465                 1470             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1475                 1480                 1485             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1490                 1495                 1500             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1505                 1510                 1515             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1520                 1525                 1530             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1535                 1540                 1545             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1550                 1555                 1560             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1565                 1570                 1575             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1580                 1585                 1590             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1595                 1600                 1605             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1610                 1615                 1620             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1625                 1630                 1635             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1640                 1645                 1650             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1655                 1660                 1665             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1670                 1675                 1680 


<210>  19
<211>  1680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Ala Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
    210                 215                 220                 


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
225                 230                 235                 240 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
                245                 250                 255     


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
            260                 265                 270         


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
        275                 280                 285             


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
    290                 295                 300                 


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
305                 310                 315                 320 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
                325                 330                 335     


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
            340                 345                 350         


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
        355                 360                 365             


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
    370                 375                 380                 


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
385                 390                 395                 400 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
                405                 410                 415     


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
            420                 425                 430         


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
        435                 440                 445             


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
    450                 455                 460                 


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
465                 470                 475                 480 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
                485                 490                 495     


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
            500                 505                 510         


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
        515                 520                 525             


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
    530                 535                 540                 


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
545                 550                 555                 560 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
                565                 570                 575     


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
            580                 585                 590         


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
        595                 600                 605             


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
    610                 615                 620                 


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
625                 630                 635                 640 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
                645                 650                 655     


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
            660                 665                 670         


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
        675                 680                 685             


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
    690                 695                 700                 


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
705                 710                 715                 720 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
                725                 730                 735     


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
            740                 745                 750         


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
        755                 760                 765             


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
    770                 775                 780                 


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
785                 790                 795                 800 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
                805                 810                 815     


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
            820                 825                 830         


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
        835                 840                 845             


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
    850                 855                 860                 


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
865                 870                 875                 880 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
                885                 890                 895     


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
            900                 905                 910         


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
        915                 920                 925             


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
    930                 935                 940                 


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
945                 950                 955                 960 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
                965                 970                 975     


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
            980                 985                 990         


Glu Arg Met Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
        995                 1000                 1005             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1010                 1015                 1020             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1025                 1030                 1035             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1040                 1045                 1050             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1055                 1060                 1065             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1070                 1075                 1080             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1085                 1090                 1095             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1100                 1105                 1110             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1115                 1120                 1125             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1130                 1135                 1140             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1145                 1150                 1155             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1160                 1165                 1170             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1175                 1180                 1185             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1190                 1195                 1200             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1205                 1210                 1215             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1220                 1225                 1230             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1235                 1240                 1245             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1250                 1255                 1260             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1265                 1270                 1275             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1280                 1285                 1290             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1295                 1300                 1305             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1310                 1315                 1320             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1325                 1330                 1335             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1340                 1345                 1350             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1355                 1360                 1365             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1370                 1375                 1380             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1385                 1390                 1395             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1400                 1405                 1410             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1415                 1420                 1425             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1430                 1435                 1440             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1445                 1450                 1455             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1460                 1465                 1470             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1475                 1480                 1485             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1490                 1495                 1500             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1505                 1510                 1515             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1520                 1525                 1530             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1535                 1540                 1545             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1550                 1555                 1560             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1565                 1570                 1575             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1580                 1585                 1590             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1595                 1600                 1605             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1610                 1615                 1620             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1625                 1630                 1635             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1640                 1645                 1650             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1655                 1660                 1665             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1670                 1675                 1680 


<210>  20
<211>  1680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Tyr Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn Ser Gly Ser Glu Thr Pro Gly Thr Ser 
        195                 200                 205             


Glu Ser Ala Thr Pro Glu Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala 
    210                 215                 220                 


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
225                 230                 235                 240 


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
                245                 250                 255     


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
            260                 265                 270         


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
        275                 280                 285             


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
    290                 295                 300                 


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
305                 310                 315                 320 


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
                325                 330                 335     


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
            340                 345                 350         


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
        355                 360                 365             


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
    370                 375                 380                 


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
385                 390                 395                 400 


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
                405                 410                 415     


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
            420                 425                 430         


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
        435                 440                 445             


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
    450                 455                 460                 


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
465                 470                 475                 480 


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
                485                 490                 495     


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
            500                 505                 510         


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
        515                 520                 525             


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
    530                 535                 540                 


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
545                 550                 555                 560 


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
                565                 570                 575     


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
            580                 585                 590         


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
        595                 600                 605             


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
    610                 615                 620                 


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
625                 630                 635                 640 


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
                645                 650                 655     


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
            660                 665                 670         


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
        675                 680                 685             


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
    690                 695                 700                 


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
705                 710                 715                 720 


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
                725                 730                 735     


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
            740                 745                 750         


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
        755                 760                 765             


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
    770                 775                 780                 


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
785                 790                 795                 800 


Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys 
                805                 810                 815     


Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp 
            820                 825                 830         


Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu 
        835                 840                 845             


Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln 
    850                 855                 860                 


Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 
865                 870                 875                 880 


Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe 
                885                 890                 895     


Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His 
            900                 905                 910         


Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser 
        915                 920                 925             


Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser 
    930                 935                 940                 


Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu 
945                 950                 955                 960 


Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu 
                965                 970                 975     


Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg 
            980                 985                 990         


Glu Arg Met Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
        995                 1000                 1005             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1010                 1015                 1020             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1025                 1030                 1035             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1040                 1045                 1050             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1055                 1060                 1065             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1070                 1075                 1080             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1085                 1090                 1095             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1100                 1105                 1110             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1115                 1120                 1125             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1130                 1135                 1140             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1145                 1150                 1155             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1160                 1165                 1170             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1175                 1180                 1185             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1190                 1195                 1200             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1205                 1210                 1215             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1220                 1225                 1230             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1235                 1240                 1245             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1250                 1255                 1260             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1265                 1270                 1275             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1280                 1285                 1290             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1295                 1300                 1305             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1310                 1315                 1320             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1325                 1330                 1335             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1340                 1345                 1350             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1355                 1360                 1365             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1370                 1375                 1380             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1385                 1390                 1395             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1400                 1405                 1410             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1415                 1420                 1425             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1430                 1435                 1440             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1445                 1450                 1455             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1460                 1465                 1470             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1475                 1480                 1485             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1490                 1495                 1500             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1505                 1510                 1515             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1520                 1525                 1530             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1535                 1540                 1545             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1550                 1555                 1560             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1565                 1570                 1575             


Leu Gly  Gly Asp Ser Gly Gly  Ser Thr Asn Leu Ser  Asp Ile Ile 
    1580                 1585                 1590             


Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile Gln Glu  Ser Ile Leu 
    1595                 1600                 1605             


Met Leu  Pro Glu Glu Val Glu  Glu Val Ile Gly Asn  Lys Pro Glu 
    1610                 1615                 1620             


Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp Glu Ser  Thr Asp Glu 
    1625                 1630                 1635             


Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro Glu Tyr  Lys Pro Trp 
    1640                 1645                 1650             


Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu Asn Lys  Ile Lys Met 
    1655                 1660                 1665             


Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1670                 1675                 1680 


<210>  21
<211>  8442
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg       60

cccagtacat gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg      120

ctattaccat ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag cggtttgact      180

cacggggatt tccaagtctc caccccattg acgtcaatgg gagtttgttt tggcaccaaa      240

atcaacggga ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa atgggcggta      300

ggcgtgtacg gtgggaggtc tatataagca gagctggttt agtgaaccgt cagatccgct      360

agagatccgc ggccgctaat acgactcact atagggagag ccgccaccat ggaagccagc      420

ccagcatccg ggcccagaca cttgatggat ccacacatat tcacttccaa ctttaacaat      480

ggcattggaa ggcataagac ctacctgtgc tacgaagtgg agcgcctgga caatggcacc      540

tcggtcaaga tggaccagca caggggcttt ctacacaacc aggctaagaa tcttctctgt      600

ggcttttacg gccgccatgc ggagctgcgc ttcttggacc tggttccttc tttgcagttg      660

gacccggccc agatctacag ggtcacttgg ttcatctcct ggagcccctg cttctcctgg      720

ggctgtgccg gggaagtgcg tgcgttcctt caggagaaca cacacgtgag actgcgtatc      780

ttcgctgccc gcatctatga ttacgacccc ctatataagg aggcactgca aatgctgcgg      840

gatgctgggg cccaagtctc catcatgacc tacgatgaat ttaagcactg ctgggacacc      900

tttgtggacc accagggatg tcccttccag ccctgggatg gactagatga gcacagccaa      960

gccctgagtg ggaggctgcg ggccattctc cagaatcagg gaaacagcgg cagcgagact     1020

cccgggacct cagagtccgc cacacccgaa agtgataaaa agtattctat tggtttagcc     1080

atcggcacta attccgttgg atgggctgtc ataaccgatg aatacaaagt accttcaaag     1140

aaatttaagg tgttggggaa cacagaccgt cattcgatta aaaagaatct tatcggtgcc     1200

ctcctattcg atagtggcga aacggcagag gcgactcgcc tgaaacgaac cgctcggaga     1260

aggtatacac gtcgcaagaa ccgaatatgt tacttacaag aaatttttag caatgagatg     1320

gccaaagttg acgattcttt ctttcaccgt ttggaagagt ccttccttgt cgaagaggac     1380

aagaaacatg aacggcaccc catctttgga aacatagtag atgaggtggc atatcatgaa     1440

aagtacccaa cgatttatca cctcagaaaa aagctagttg actcaactga taaagcggac     1500

ctgaggttaa tctacttggc tcttgcccat atgataaagt tccgtgggca ctttctcatt     1560

gagggtgatc taaatccgga caactcggat gtcgacaaac tgttcatcca gttagtacaa     1620

acctataatc agttgtttga agagaaccct ataaatgcaa gtggcgtgga tgcgaaggct     1680

attcttagcg cccgcctctc taaatcccga cggctagaaa acctgatcgc acaattaccc     1740

ggagagaaga aaaatgggtt gttcggtaac cttatagcgc tctcactagg cctgacacca     1800

aattttaagt cgaacttcga cttagctgaa gatgccaaat tgcagcttag taaggacacg     1860

tacgatgacg atctcgacaa tctactggca caaattggag atcagtatgc ggacttattt     1920

ttggctgcca aaaaccttag cgatgcaatc ctcctatctg acatactgag agttaatact     1980

gagattacca aggcgccgtt atccgcttca atgatcaaaa ggtacgatga acatcaccaa     2040

gacttgacac ttctcaaggc cctagtccgt cagcaactgc ctgagaaata taaggaaata     2100

ttctttgatc agtcgaaaaa cgggtacgca ggttatattg acggcggagc gagtcaagag     2160

gaattctaca agtttatcaa acccatatta gagaagatgg atgggacgga agagttgctt     2220

gtaaaactca atcgcgaaga tctactgcga aagcagcgga ctttcgacaa cggtagcatt     2280

ccacatcaaa tccacttagg cgaattgcat gctatactta gaaggcagga ggatttttat     2340

ccgttcctca aagacaatcg tgaaaagatt gagaaaatcc taacctttcg cataccttac     2400

tatgtgggac ccctggcccg agggaactct cggttcgcat ggatgacaag aaagtccgaa     2460

gaaacgatta ctccatggaa ttttgaggaa gttgtcgata aaggtgcgtc agctcaatcg     2520

ttcatcgaga ggatgaccaa ctttgacaag aatttaccga acgaaaaagt attgcctaag     2580

cacagtttac tttacgagta tttcacagtg tacaatgaac tcacgaaagt taagtatgtc     2640

actgagggca tgcgtaaacc cgcctttcta agcggagaac agaagaaagc aatagtagat     2700

ctgttattca agaccaaccg caaagtgaca gttaagcaat tgaaagagga ctactttaag     2760

aaaattgaat gcttcgattc tgtcgagatc tccggggtag aagatcgatt taatgcgtca     2820

cttggtacgt atcatgacct cctaaagata attaaagata aggacttcct ggataacgaa     2880

gagaatgaag atatcttaga agatatagtg ttgactctta ccctctttga agatcgggaa     2940

atgattgagg aaagactaaa aacatacgct cacctgttcg acgataaggt tatgaaacag     3000

ttaaagaggc gtcgctatac gggctgggga cgattgtcgc ggaaacttat caacgggata     3060

agagacaagc aaagtggtaa aactattctc gattttctaa agagcgacgg cttcgccaat     3120

aggaacttta tgcagctgat ccatgatgac tctttaacct tcaaagagga tatacaaaag     3180

gcacaggttt ccggacaagg ggactcattg cacgaacata ttgcgaatct tgctggttcg     3240

ccagccatca aaaagggcat actccagaca gtcaaagtag tggatgagct agttaaggtc     3300

atgggacgtc acaaaccgga aaacattgta atcgagatgg cacgcgaaaa tcaaacgact     3360

cagaaggggc aaaaaaacag tcgagagcgg atgaagagaa tagaagaggg tattaaagaa     3420

ctgggcagcc agatcttaaa ggagcatcct gtggaaaata cccaattgca gaacgagaaa     3480

ctttacctct attacctaca aaatggaagg gacatgtatg ttgatcagga actggacata     3540

aaccgtttat ctgattacga cgtcgatcac attgtacccc aatccttttt gaaggacgat     3600

tcaatcgaca ataaagtgct tacacgctcg gataagaacc gagggaaaag tgacaatgtt     3660

ccaagcgagg aagtcgtaaa gaaaatgaag aactattggc ggcagctcct aaatgcgaaa     3720

ctgataacgc aaagaaagtt cgataactta actaaagctg agaggggtgg cttgtctgaa     3780

cttgacaagg ccggatttat taaacgtcag ctcgtggaaa cccgccaaat cacaaagcat     3840

gttgcacaga tactagattc ccgaatgaat acgaaatacg acgagaacga taagctgatt     3900

cgggaagtca aagtaatcac tttaaagtca aaattggtgt cggacttcag aaaggatttt     3960

caattctata aagttaggga gataaataac taccaccatg cgcacgacgc ttatcttaat     4020

gccgtcgtag ggaccgcact cattaagaaa tacccgaagc tagaaagtga gtttgtgtat     4080

ggtgattaca aagtttatga cgtccgtaag atgatcgcga aaagcgaaca ggagataggc     4140

aaggctacag ccaaatactt cttttattct aacattatga atttctttaa gacggaaatc     4200

actctggcaa acggagagat acgcaaacga cctttaattg aaaccaatgg ggagacaggt     4260

gaaatcgtat gggataaggg ccgggacttc gcgacggtga gaaaagtttt gtccatgccc     4320

caagtcaaca tagtaaagaa aactgaggtg cagaccggag ggttttcaaa ggaatcgatt     4380

cttccaaaaa ggaatagtga taagctcatc gctcgtaaaa aggactggga cccgaaaaag     4440

tacggtggct tcgatagccc tacagttgcc tattctgtcc tagtagtggc aaaagttgag     4500

aagggaaaat ccaagaaact gaagtcagtc aaagaattat tggggataac gattatggag     4560

cgctcgtctt ttgaaaagaa ccccatcgac ttccttgagg cgaaaggtta caaggaagta     4620

aaaaaggatc tcataattaa actaccaaag tatagtctgt ttgagttaga aaatggccga     4680

aaacggatgt tggctagcgc cggagagctt caaaagggga acgaactcgc actaccgtct     4740

aaatacgtga atttcctgta tttagcgtcc cattacgaga agttgaaagg ttcacctgaa     4800

gataacgaac agaagcaact ttttgttgag cagcacaaac attatctcga cgaaatcata     4860

gagcaaattt cggaattcag taagagagtc atcctagctg atgccaatct ggacaaagta     4920

ttaagcgcat acaacaagca cagggataaa cccatacgtg agcaggcgga aaatattatc     4980

catttgttta ctcttaccaa cctcggcgct ccagccgcat tcaagtattt tgacacaacg     5040

atagatcgca aacgatacac ttctaccaag gaggtgctag acgcgacact gattcaccaa     5100

tccatcacgg gattatatga aactcggata gatttgtcac agcttggggg tgactctggt     5160

ggttctacta atctgtcaga tattattgaa aaggagaccg gtaagcaact ggttatccag     5220

gaatccatcc tcatgctccc agaggaggtg gaagaagtca ttgggaacaa gccggaaagc     5280

gatatactcg tgcacaccgc ctacgacgag agcaccgacg agaatgtcat gcttctgact     5340

agcgacgccc ctgaatacaa gccttgggct ctggtcatac aggatagcaa cggtgagaac     5400

aagattaaga tgctctctgg tggttctccc aagaagaaga ggaaagtcta accggtcatc     5460

atcaccatca ccattgagtt taaacccgct gatcagcctc gactgtgcct tctagttgcc     5520

agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca     5580

ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta     5640

ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc     5700

atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggctcga     5760

taccgtcgac ctctagctag agcttggcgt aatcatggtc atagctgttt cctgtgtgaa     5820

attgttatcc gctcacaatt ccacacaaca tacgagccgg aagcataaag tgtaaagcct     5880

agggtgccta atgagtgagc taactcacat taattgcgtt gcgctcactg cccgctttcc     5940

agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg     6000

gtttgcgtat tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     6060

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     6120

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     6180

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     6240

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     6300

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     6360

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     6420

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     6480

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     6540

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     6600

agttcttgaa gtggtggcct aactacggct acactagaag aacagtattt ggtatctgcg     6660

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     6720

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     6780

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     6840

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     6900

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     6960

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     7020

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     7080

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     7140

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     7200

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     7260

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     7320

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     7380

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     7440

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     7500

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     7560

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     7620

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     7680

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     7740

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     7800

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     7860

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     7920

cgcgcacatt tccccgaaaa gtgccacctg acgtcgacgg atcgggagat cgatctcccg     7980

atcccctagg gtcgactctc agtacaatct gctctgatgc cgcatagtta agccagtatc     8040

tgctccctgc ttgtgtgttg gaggtcgctg agtagtgcgc gagcaaaatt taagctacaa     8100

caaggcaagg cttgaccgac aattgcatga agaatctgct tagggttagg cgttttgcgc     8160

tgcttcgcga tgtacgggcc agatatacgc gttgacattg attattgact agttattaat     8220

agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac     8280

ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa     8340

tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt     8400

atttacggta aactgcccac ttggcagtac atcaagtgta tc                        8442


<210>  22
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Phe Glu Asp Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  23
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Phe Tyr Asp Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  24
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Tyr Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  25
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Tyr Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  26
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Tyr Ser Pro Cys Phe Ser Ala Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  27
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Tyr Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Tyr Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  28
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Ala Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Tyr Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  29
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Tyr Ser Pro Cys Phe Ser Ala Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Phe Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  30
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Tyr Ser Pro Cys Phe Ser Ala Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Asp Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  31
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Ala Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Phe Asp Tyr Asp Tyr Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  32
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Ala Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Asp Asp Tyr Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  33
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Ala Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Phe Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  34
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Ala Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Asp Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210>  35
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Lys Thr Tyr Leu Cys 
1               5                   10                  15      


Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met Asp Gln 
            20                  25                  30          


His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe 
        35                  40                  45              


Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro Ser Leu 
    50                  55                  60                  


Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Tyr 
65                  70                  75                  80  


Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala Phe Leu 
                85                  90                  95      


Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr 
            100                 105                 110         


Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala 
        115                 120                 125             


Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His Cys Trp 
    130                 135                 140                 


Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly 
145                 150                 155                 160 


Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu 
                165                 170                 175     


Gln Asn Gln Gly Asn 
            180     


<210>  36
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Lys Thr Tyr Leu Cys 
1               5                   10                  15      


Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met Asp Gln 
            20                  25                  30          


His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe 
        35                  40                  45              


Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro Ser Leu 
    50                  55                  60                  


Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp 
65                  70                  75                  80  


Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala Phe Leu 
                85                  90                  95      


Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr 
            100                 105                 110         


Asp Tyr Asp Tyr Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala 
        115                 120                 125             


Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His Cys Trp 
    130                 135                 140                 


Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly 
145                 150                 155                 160 


Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu 
                165                 170                 175     


Gln Asn Gln Gly Asn 
            180     


<210>  37
<211>  1230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Ala 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Ala Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Ala Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His Gly Ser  
    1220                 1225                 1230 


<210>  38
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  39
<211>  1300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  40
<211>  1558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Met Pro Lys Lys Lys Arg Lys Val Met Glu Ala Ser Pro Ala Ser Gly 
1               5                   10                  15      


Pro Arg His Leu Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn 
            20                  25                  30          


Gly Ile Gly Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu 
        35                  40                  45              


Asp Asn Gly Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His 
    50                  55                  60                  


Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu 
65                  70                  75                  80  


Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln 
                85                  90                  95      


Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp 
            100                 105                 110         


Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val 
        115                 120                 125             


Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr 
    130                 135                 140                 


Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile 
145                 150                 155                 160 


Met Thr Tyr Asp Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His 
                165                 170                 175     


Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
            180                 185                 190         


Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser 
        195                 200                 205             


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met 
    210                 215                 220                 


Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu 
225                 230                 235                 240 


Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn 
                245                 250                 255     


Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly 
            260                 265                 270         


Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val 
        275                 280                 285             


Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe 
    290                 295                 300                 


Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu 
305                 310                 315                 320 


Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu 
                325                 330                 335     


Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro 
            340                 345                 350         


Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn 
        355                 360                 365             


Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met 
    370                 375                 380                 


Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn 
385                 390                 395                 400 


Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val 
                405                 410                 415     


Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile 
            420                 425                 430         


Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe 
        435                 440                 445             


Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile 
    450                 455                 460                 


Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu 
465                 470                 475                 480 


Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe 
                485                 490                 495     


Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe 
            500                 505                 510         


Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg 
        515                 520                 525             


Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu 
    530                 535                 540                 


Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe 
545                 550                 555                 560 


Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly 
                565                 570                 575     


Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile 
            580                 585                 590         


His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg 
        595                 600                 605             


Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln 
    610                 615                 620                 


Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile 
625                 630                 635                 640 


Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu 
                645                 650                 655     


Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn 
            660                 665                 670         


Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser 
        675                 680                 685             


Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn 
    690                 695                 700                 


Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu 
705                 710                 715                 720 


Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln 
                725                 730                 735     


Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln 
            740                 745                 750         


Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr 
        755                 760                 765             


Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys 
    770                 775                 780                 


Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn 
785                 790                 795                 800 


Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu 
                805                 810                 815     


Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser 
            820                 825                 830         


Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp 
        835                 840                 845             


Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp 
    850                 855                 860                 


Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe 
865                 870                 875                 880 


Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val 
                885                 890                 895     


Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu 
            900                 905                 910         


Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr 
        915                 920                 925             


Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr 
    930                 935                 940                 


Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg 
945                 950                 955                 960 


Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys 
                965                 970                 975     


Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn 
            980                 985                 990         


Pro Asp Asn Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
        995                 1000                 1005             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1010                 1015                 1020             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1025                 1030                 1035             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1040                 1045                 1050             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1055                 1060                 1065             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1070                 1075                 1080             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1085                 1090                 1095             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1100                 1105                 1110             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1115                 1120                 1125             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1130                 1135                 1140             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1145                 1150                 1155             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1160                 1165                 1170             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1175                 1180                 1185             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1190                 1195                 1200             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1205                 1210                 1215             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1220                 1225                 1230             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1235                 1240                 1245             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1250                 1255                 1260             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1265                 1270                 1275             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1280                 1285                 1290             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1295                 1300                 1305             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1310                 1315                 1320             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1325                 1330                 1335             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1340                 1345                 1350             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1355                 1360                 1365             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1370                 1375                 1380             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1385                 1390                 1395             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1400                 1405                 1410             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1415                 1420                 1425             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1430                 1435                 1440             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1445                 1450                 1455             


Lys Val  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1460                 1465                 1470             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1475                 1480                 1485             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1490                 1495                 1500             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1505                 1510                 1515             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1520                 1525                 1530             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1535                 1540                 1545             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1550                 1555             


<210>  41
<211>  1558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Met Pro Lys Lys Lys Arg Lys Val Met Glu Ala Ser Pro Ala Ser Gly 
1               5                   10                  15      


Pro Arg His Leu Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn 
            20                  25                  30          


Gly Ile Gly Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu 
        35                  40                  45              


Asp Asn Gly Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His 
    50                  55                  60                  


Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu 
65                  70                  75                  80  


Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln 
                85                  90                  95      


Ile Tyr Arg Val Thr Trp Phe Ile Ser Tyr Ser Pro Cys Phe Ser Trp 
            100                 105                 110         


Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val 
        115                 120                 125             


Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr 
    130                 135                 140                 


Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile 
145                 150                 155                 160 


Met Thr Tyr Asp Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His 
                165                 170                 175     


Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
            180                 185                 190         


Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser 
        195                 200                 205             


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met 
    210                 215                 220                 


Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu 
225                 230                 235                 240 


Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn 
                245                 250                 255     


Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly 
            260                 265                 270         


Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val 
        275                 280                 285             


Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe 
    290                 295                 300                 


Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu 
305                 310                 315                 320 


Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu 
                325                 330                 335     


Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro 
            340                 345                 350         


Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn 
        355                 360                 365             


Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met 
    370                 375                 380                 


Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn 
385                 390                 395                 400 


Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val 
                405                 410                 415     


Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile 
            420                 425                 430         


Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe 
        435                 440                 445             


Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile 
    450                 455                 460                 


Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu 
465                 470                 475                 480 


Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe 
                485                 490                 495     


Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe 
            500                 505                 510         


Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg 
        515                 520                 525             


Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu 
    530                 535                 540                 


Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe 
545                 550                 555                 560 


Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly 
                565                 570                 575     


Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile 
            580                 585                 590         


His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg 
        595                 600                 605             


Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln 
    610                 615                 620                 


Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile 
625                 630                 635                 640 


Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu 
                645                 650                 655     


Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn 
            660                 665                 670         


Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser 
        675                 680                 685             


Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn 
    690                 695                 700                 


Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu 
705                 710                 715                 720 


Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln 
                725                 730                 735     


Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln 
            740                 745                 750         


Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr 
        755                 760                 765             


Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys 
    770                 775                 780                 


Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn 
785                 790                 795                 800 


Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu 
                805                 810                 815     


Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser 
            820                 825                 830         


Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp 
        835                 840                 845             


Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp 
    850                 855                 860                 


Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe 
865                 870                 875                 880 


Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val 
                885                 890                 895     


Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu 
            900                 905                 910         


Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr 
        915                 920                 925             


Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr 
    930                 935                 940                 


Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg 
945                 950                 955                 960 


Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys 
                965                 970                 975     


Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn 
            980                 985                 990         


Pro Asp Asn Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
        995                 1000                 1005             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1010                 1015                 1020             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1025                 1030                 1035             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1040                 1045                 1050             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1055                 1060                 1065             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1070                 1075                 1080             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1085                 1090                 1095             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1100                 1105                 1110             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1115                 1120                 1125             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1130                 1135                 1140             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1145                 1150                 1155             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1160                 1165                 1170             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1175                 1180                 1185             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1190                 1195                 1200             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1205                 1210                 1215             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1220                 1225                 1230             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1235                 1240                 1245             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1250                 1255                 1260             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1265                 1270                 1275             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1280                 1285                 1290             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1295                 1300                 1305             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1310                 1315                 1320             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1325                 1330                 1335             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1340                 1345                 1350             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1355                 1360                 1365             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1370                 1375                 1380             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1385                 1390                 1395             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1400                 1405                 1410             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1415                 1420                 1425             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1430                 1435                 1440             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1445                 1450                 1455             


Lys Val  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1460                 1465                 1470             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1475                 1480                 1485             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1490                 1495                 1500             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1505                 1510                 1515             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1520                 1525                 1530             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1535                 1540                 1545             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1550                 1555             


<210>  42
<211>  1558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Met Pro Lys Lys Lys Arg Lys Val Met Glu Ala Ser Pro Ala Ser Gly 
1               5                   10                  15      


Pro Arg His Leu Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn 
            20                  25                  30          


Gly Ile Gly Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu 
        35                  40                  45              


Asp Asn Gly Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His 
    50                  55                  60                  


Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu 
65                  70                  75                  80  


Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln 
                85                  90                  95      


Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Ala 
            100                 105                 110         


Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val 
        115                 120                 125             


Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr 
    130                 135                 140                 


Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile 
145                 150                 155                 160 


Met Thr Tyr Asp Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His 
                165                 170                 175     


Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
            180                 185                 190         


Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser 
        195                 200                 205             


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met 
    210                 215                 220                 


Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu 
225                 230                 235                 240 


Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn 
                245                 250                 255     


Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly 
            260                 265                 270         


Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val 
        275                 280                 285             


Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe 
    290                 295                 300                 


Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu 
305                 310                 315                 320 


Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu 
                325                 330                 335     


Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro 
            340                 345                 350         


Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn 
        355                 360                 365             


Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met 
    370                 375                 380                 


Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn 
385                 390                 395                 400 


Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val 
                405                 410                 415     


Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile 
            420                 425                 430         


Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe 
        435                 440                 445             


Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile 
    450                 455                 460                 


Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu 
465                 470                 475                 480 


Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe 
                485                 490                 495     


Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe 
            500                 505                 510         


Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg 
        515                 520                 525             


Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu 
    530                 535                 540                 


Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe 
545                 550                 555                 560 


Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly 
                565                 570                 575     


Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile 
            580                 585                 590         


His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg 
        595                 600                 605             


Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln 
    610                 615                 620                 


Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile 
625                 630                 635                 640 


Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu 
                645                 650                 655     


Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn 
            660                 665                 670         


Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser 
        675                 680                 685             


Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn 
    690                 695                 700                 


Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu 
705                 710                 715                 720 


Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln 
                725                 730                 735     


Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln 
            740                 745                 750         


Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr 
        755                 760                 765             


Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys 
    770                 775                 780                 


Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn 
785                 790                 795                 800 


Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu 
                805                 810                 815     


Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser 
            820                 825                 830         


Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp 
        835                 840                 845             


Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp 
    850                 855                 860                 


Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe 
865                 870                 875                 880 


Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val 
                885                 890                 895     


Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu 
            900                 905                 910         


Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr 
        915                 920                 925             


Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr 
    930                 935                 940                 


Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg 
945                 950                 955                 960 


Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys 
                965                 970                 975     


Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn 
            980                 985                 990         


Pro Asp Asn Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
        995                 1000                 1005             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1010                 1015                 1020             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1025                 1030                 1035             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1040                 1045                 1050             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1055                 1060                 1065             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1070                 1075                 1080             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1085                 1090                 1095             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1100                 1105                 1110             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1115                 1120                 1125             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1130                 1135                 1140             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1145                 1150                 1155             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1160                 1165                 1170             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1175                 1180                 1185             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1190                 1195                 1200             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1205                 1210                 1215             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1220                 1225                 1230             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1235                 1240                 1245             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1250                 1255                 1260             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1265                 1270                 1275             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1280                 1285                 1290             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1295                 1300                 1305             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1310                 1315                 1320             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1325                 1330                 1335             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1340                 1345                 1350             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1355                 1360                 1365             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1370                 1375                 1380             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1385                 1390                 1395             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1400                 1405                 1410             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1415                 1420                 1425             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1430                 1435                 1440             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1445                 1450                 1455             


Lys Val  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1460                 1465                 1470             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1475                 1480                 1485             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1490                 1495                 1500             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1505                 1510                 1515             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1520                 1525                 1530             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1535                 1540                 1545             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1550                 1555             


<210>  43
<211>  1558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Met Pro Lys Lys Lys Arg Lys Val Met Glu Ala Ser Pro Ala Ser Gly 
1               5                   10                  15      


Pro Arg His Leu Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn 
            20                  25                  30          


Gly Ile Gly Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu 
        35                  40                  45              


Asp Asn Gly Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His 
    50                  55                  60                  


Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu 
65                  70                  75                  80  


Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln 
                85                  90                  95      


Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp 
            100                 105                 110         


Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val 
        115                 120                 125             


Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Tyr Leu Tyr 
    130                 135                 140                 


Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile 
145                 150                 155                 160 


Met Thr Tyr Asp Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His 
                165                 170                 175     


Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
            180                 185                 190         


Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser 
        195                 200                 205             


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met 
    210                 215                 220                 


Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu 
225                 230                 235                 240 


Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn 
                245                 250                 255     


Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly 
            260                 265                 270         


Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val 
        275                 280                 285             


Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe 
    290                 295                 300                 


Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu 
305                 310                 315                 320 


Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu 
                325                 330                 335     


Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro 
            340                 345                 350         


Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn 
        355                 360                 365             


Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met 
    370                 375                 380                 


Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn 
385                 390                 395                 400 


Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val 
                405                 410                 415     


Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile 
            420                 425                 430         


Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe 
        435                 440                 445             


Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile 
    450                 455                 460                 


Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu 
465                 470                 475                 480 


Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe 
                485                 490                 495     


Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe 
            500                 505                 510         


Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg 
        515                 520                 525             


Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu 
    530                 535                 540                 


Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe 
545                 550                 555                 560 


Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly 
                565                 570                 575     


Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile 
            580                 585                 590         


His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg 
        595                 600                 605             


Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln 
    610                 615                 620                 


Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile 
625                 630                 635                 640 


Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu 
                645                 650                 655     


Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn 
            660                 665                 670         


Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser 
        675                 680                 685             


Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn 
    690                 695                 700                 


Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu 
705                 710                 715                 720 


Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln 
                725                 730                 735     


Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln 
            740                 745                 750         


Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr 
        755                 760                 765             


Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys 
    770                 775                 780                 


Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn 
785                 790                 795                 800 


Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu 
                805                 810                 815     


Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser 
            820                 825                 830         


Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp 
        835                 840                 845             


Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp 
    850                 855                 860                 


Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe 
865                 870                 875                 880 


Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val 
                885                 890                 895     


Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu 
            900                 905                 910         


Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr 
        915                 920                 925             


Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr 
    930                 935                 940                 


Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg 
945                 950                 955                 960 


Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys 
                965                 970                 975     


Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn 
            980                 985                 990         


Pro Asp Asn Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
        995                 1000                 1005             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1010                 1015                 1020             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1025                 1030                 1035             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1040                 1045                 1050             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1055                 1060                 1065             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1070                 1075                 1080             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1085                 1090                 1095             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1100                 1105                 1110             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1115                 1120                 1125             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1130                 1135                 1140             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1145                 1150                 1155             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1160                 1165                 1170             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1175                 1180                 1185             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1190                 1195                 1200             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1205                 1210                 1215             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1220                 1225                 1230             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1235                 1240                 1245             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1250                 1255                 1260             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1265                 1270                 1275             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1280                 1285                 1290             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1295                 1300                 1305             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1310                 1315                 1320             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1325                 1330                 1335             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1340                 1345                 1350             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1355                 1360                 1365             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1370                 1375                 1380             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1385                 1390                 1395             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1400                 1405                 1410             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1415                 1420                 1425             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1430                 1435                 1440             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1445                 1450                 1455             


Lys Val  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1460                 1465                 1470             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1475                 1480                 1485             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1490                 1495                 1500             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1505                 1510                 1515             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1520                 1525                 1530             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1535                 1540                 1545             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1550                 1555             


<210>  44
<211>  1558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Met Pro Lys Lys Lys Arg Lys Val Met Glu Ala Ser Pro Ala Ser Gly 
1               5                   10                  15      


Pro Arg His Leu Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn 
            20                  25                  30          


Gly Ile Gly Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu 
        35                  40                  45              


Asp Asn Gly Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His 
    50                  55                  60                  


Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu 
65                  70                  75                  80  


Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln 
                85                  90                  95      


Ile Tyr Arg Val Thr Trp Phe Ile Ser Tyr Ser Pro Cys Phe Ser Ala 
            100                 105                 110         


Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val 
        115                 120                 125             


Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr 
    130                 135                 140                 


Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile 
145                 150                 155                 160 


Met Thr Tyr Asp Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His 
                165                 170                 175     


Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
            180                 185                 190         


Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser 
        195                 200                 205             


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met 
    210                 215                 220                 


Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu 
225                 230                 235                 240 


Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn 
                245                 250                 255     


Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly 
            260                 265                 270         


Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val 
        275                 280                 285             


Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe 
    290                 295                 300                 


Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu 
305                 310                 315                 320 


Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu 
                325                 330                 335     


Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro 
            340                 345                 350         


Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn 
        355                 360                 365             


Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met 
    370                 375                 380                 


Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn 
385                 390                 395                 400 


Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val 
                405                 410                 415     


Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile 
            420                 425                 430         


Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe 
        435                 440                 445             


Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile 
    450                 455                 460                 


Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu 
465                 470                 475                 480 


Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe 
                485                 490                 495     


Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe 
            500                 505                 510         


Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg 
        515                 520                 525             


Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu 
    530                 535                 540                 


Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe 
545                 550                 555                 560 


Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly 
                565                 570                 575     


Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile 
            580                 585                 590         


His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg 
        595                 600                 605             


Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln 
    610                 615                 620                 


Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile 
625                 630                 635                 640 


Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu 
                645                 650                 655     


Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn 
            660                 665                 670         


Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser 
        675                 680                 685             


Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn 
    690                 695                 700                 


Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu 
705                 710                 715                 720 


Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln 
                725                 730                 735     


Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln 
            740                 745                 750         


Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr 
        755                 760                 765             


Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys 
    770                 775                 780                 


Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn 
785                 790                 795                 800 


Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu 
                805                 810                 815     


Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser 
            820                 825                 830         


Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp 
        835                 840                 845             


Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp 
    850                 855                 860                 


Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe 
865                 870                 875                 880 


Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val 
                885                 890                 895     


Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu 
            900                 905                 910         


Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr 
        915                 920                 925             


Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr 
    930                 935                 940                 


Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg 
945                 950                 955                 960 


Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys 
                965                 970                 975     


Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn 
            980                 985                 990         


Pro Asp Asn Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
        995                 1000                 1005             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1010                 1015                 1020             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1025                 1030                 1035             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1040                 1045                 1050             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1055                 1060                 1065             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1070                 1075                 1080             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1085                 1090                 1095             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1100                 1105                 1110             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1115                 1120                 1125             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1130                 1135                 1140             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1145                 1150                 1155             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1160                 1165                 1170             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1175                 1180                 1185             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1190                 1195                 1200             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1205                 1210                 1215             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1220                 1225                 1230             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1235                 1240                 1245             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1250                 1255                 1260             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1265                 1270                 1275             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1280                 1285                 1290             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1295                 1300                 1305             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1310                 1315                 1320             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1325                 1330                 1335             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1340                 1345                 1350             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1355                 1360                 1365             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1370                 1375                 1380             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1385                 1390                 1395             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1400                 1405                 1410             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1415                 1420                 1425             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1430                 1435                 1440             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1445                 1450                 1455             


Lys Val  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1460                 1465                 1470             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1475                 1480                 1485             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1490                 1495                 1500             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1505                 1510                 1515             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1520                 1525                 1530             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1535                 1540                 1545             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1550                 1555             


<210>  45
<211>  1558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Met Pro Lys Lys Lys Arg Lys Val Met Glu Ala Ser Pro Ala Ser Gly 
1               5                   10                  15      


Pro Arg His Leu Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn 
            20                  25                  30          


Gly Ile Gly Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu 
        35                  40                  45              


Asp Asn Gly Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His 
    50                  55                  60                  


Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu 
65                  70                  75                  80  


Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln 
                85                  90                  95      


Ile Tyr Arg Val Thr Trp Phe Ile Ser Tyr Ser Pro Cys Phe Ser Trp 
            100                 105                 110         


Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val 
        115                 120                 125             


Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Tyr Leu Tyr 
    130                 135                 140                 


Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile 
145                 150                 155                 160 


Met Thr Tyr Asp Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His 
                165                 170                 175     


Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
            180                 185                 190         


Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser 
        195                 200                 205             


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met 
    210                 215                 220                 


Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu 
225                 230                 235                 240 


Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn 
                245                 250                 255     


Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly 
            260                 265                 270         


Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val 
        275                 280                 285             


Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe 
    290                 295                 300                 


Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu 
305                 310                 315                 320 


Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu 
                325                 330                 335     


Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro 
            340                 345                 350         


Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn 
        355                 360                 365             


Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met 
    370                 375                 380                 


Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn 
385                 390                 395                 400 


Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val 
                405                 410                 415     


Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile 
            420                 425                 430         


Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe 
        435                 440                 445             


Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile 
    450                 455                 460                 


Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu 
465                 470                 475                 480 


Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe 
                485                 490                 495     


Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe 
            500                 505                 510         


Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg 
        515                 520                 525             


Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu 
    530                 535                 540                 


Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe 
545                 550                 555                 560 


Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly 
                565                 570                 575     


Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile 
            580                 585                 590         


His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg 
        595                 600                 605             


Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln 
    610                 615                 620                 


Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile 
625                 630                 635                 640 


Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu 
                645                 650                 655     


Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn 
            660                 665                 670         


Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser 
        675                 680                 685             


Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn 
    690                 695                 700                 


Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu 
705                 710                 715                 720 


Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln 
                725                 730                 735     


Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln 
            740                 745                 750         


Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr 
        755                 760                 765             


Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys 
    770                 775                 780                 


Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn 
785                 790                 795                 800 


Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu 
                805                 810                 815     


Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser 
            820                 825                 830         


Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp 
        835                 840                 845             


Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp 
    850                 855                 860                 


Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe 
865                 870                 875                 880 


Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val 
                885                 890                 895     


Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu 
            900                 905                 910         


Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr 
        915                 920                 925             


Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr 
    930                 935                 940                 


Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg 
945                 950                 955                 960 


Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys 
                965                 970                 975     


Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn 
            980                 985                 990         


Pro Asp Asn Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
        995                 1000                 1005             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1010                 1015                 1020             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1025                 1030                 1035             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1040                 1045                 1050             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1055                 1060                 1065             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1070                 1075                 1080             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1085                 1090                 1095             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1100                 1105                 1110             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1115                 1120                 1125             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1130                 1135                 1140             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1145                 1150                 1155             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1160                 1165                 1170             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1175                 1180                 1185             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1190                 1195                 1200             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1205                 1210                 1215             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1220                 1225                 1230             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1235                 1240                 1245             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1250                 1255                 1260             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1265                 1270                 1275             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1280                 1285                 1290             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1295                 1300                 1305             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1310                 1315                 1320             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1325                 1330                 1335             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1340                 1345                 1350             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1355                 1360                 1365             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1370                 1375                 1380             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1385                 1390                 1395             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1400                 1405                 1410             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1415                 1420                 1425             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1430                 1435                 1440             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1445                 1450                 1455             


Lys Val  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1460                 1465                 1470             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1475                 1480                 1485             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1490                 1495                 1500             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1505                 1510                 1515             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1520                 1525                 1530             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1535                 1540                 1545             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1550                 1555             


<210>  46
<211>  1558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Met Pro Lys Lys Lys Arg Lys Val Met Glu Ala Ser Pro Ala Ser Gly 
1               5                   10                  15      


Pro Arg His Leu Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn 
            20                  25                  30          


Gly Ile Gly Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu 
        35                  40                  45              


Asp Asn Gly Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His 
    50                  55                  60                  


Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu 
65                  70                  75                  80  


Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln 
                85                  90                  95      


Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Ala 
            100                 105                 110         


Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val 
        115                 120                 125             


Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Tyr Leu Tyr 
    130                 135                 140                 


Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile 
145                 150                 155                 160 


Met Thr Tyr Asp Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His 
                165                 170                 175     


Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
            180                 185                 190         


Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser 
        195                 200                 205             


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met 
    210                 215                 220                 


Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu 
225                 230                 235                 240 


Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn 
                245                 250                 255     


Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly 
            260                 265                 270         


Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val 
        275                 280                 285             


Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe 
    290                 295                 300                 


Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu 
305                 310                 315                 320 


Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu 
                325                 330                 335     


Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro 
            340                 345                 350         


Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn 
        355                 360                 365             


Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met 
    370                 375                 380                 


Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn 
385                 390                 395                 400 


Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val 
                405                 410                 415     


Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile 
            420                 425                 430         


Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe 
        435                 440                 445             


Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile 
    450                 455                 460                 


Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu 
465                 470                 475                 480 


Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe 
                485                 490                 495     


Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe 
            500                 505                 510         


Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg 
        515                 520                 525             


Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu 
    530                 535                 540                 


Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe 
545                 550                 555                 560 


Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly 
                565                 570                 575     


Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile 
            580                 585                 590         


His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg 
        595                 600                 605             


Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln 
    610                 615                 620                 


Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile 
625                 630                 635                 640 


Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu 
                645                 650                 655     


Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn 
            660                 665                 670         


Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser 
        675                 680                 685             


Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn 
    690                 695                 700                 


Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu 
705                 710                 715                 720 


Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln 
                725                 730                 735     


Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln 
            740                 745                 750         


Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr 
        755                 760                 765             


Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys 
    770                 775                 780                 


Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn 
785                 790                 795                 800 


Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu 
                805                 810                 815     


Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser 
            820                 825                 830         


Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp 
        835                 840                 845             


Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp 
    850                 855                 860                 


Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe 
865                 870                 875                 880 


Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val 
                885                 890                 895     


Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu 
            900                 905                 910         


Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr 
        915                 920                 925             


Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr 
    930                 935                 940                 


Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg 
945                 950                 955                 960 


Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys 
                965                 970                 975     


Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn 
            980                 985                 990         


Pro Asp Asn Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
        995                 1000                 1005             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1010                 1015                 1020             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1025                 1030                 1035             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1040                 1045                 1050             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1055                 1060                 1065             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1070                 1075                 1080             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1085                 1090                 1095             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1100                 1105                 1110             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1115                 1120                 1125             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1130                 1135                 1140             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1145                 1150                 1155             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1160                 1165                 1170             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1175                 1180                 1185             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1190                 1195                 1200             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1205                 1210                 1215             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1220                 1225                 1230             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1235                 1240                 1245             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1250                 1255                 1260             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1265                 1270                 1275             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1280                 1285                 1290             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1295                 1300                 1305             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1310                 1315                 1320             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1325                 1330                 1335             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1340                 1345                 1350             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1355                 1360                 1365             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1370                 1375                 1380             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1385                 1390                 1395             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1400                 1405                 1410             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1415                 1420                 1425             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1430                 1435                 1440             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1445                 1450                 1455             


Lys Val  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1460                 1465                 1470             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1475                 1480                 1485             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1490                 1495                 1500             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1505                 1510                 1515             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1520                 1525                 1530             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1535                 1540                 1545             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1550                 1555             


<210>  47
<211>  1558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Met Pro Lys Lys Lys Arg Lys Val Met Glu Ala Ser Pro Ala Ser Gly 
1               5                   10                  15      


Pro Arg His Leu Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn 
            20                  25                  30          


Gly Ile Gly Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu 
        35                  40                  45              


Asp Asn Gly Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His 
    50                  55                  60                  


Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu 
65                  70                  75                  80  


Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln 
                85                  90                  95      


Ile Tyr Arg Val Thr Trp Phe Ile Ser Tyr Ser Pro Cys Phe Ser Ala 
            100                 105                 110         


Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val 
        115                 120                 125             


Arg Leu Arg Ile Phe Ala Ala Arg Ile Phe Asp Tyr Asp Pro Leu Tyr 
    130                 135                 140                 


Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile 
145                 150                 155                 160 


Met Thr Tyr Asp Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His 
                165                 170                 175     


Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
            180                 185                 190         


Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser 
        195                 200                 205             


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met 
    210                 215                 220                 


Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu 
225                 230                 235                 240 


Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn 
                245                 250                 255     


Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly 
            260                 265                 270         


Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val 
        275                 280                 285             


Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe 
    290                 295                 300                 


Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu 
305                 310                 315                 320 


Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu 
                325                 330                 335     


Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro 
            340                 345                 350         


Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn 
        355                 360                 365             


Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met 
    370                 375                 380                 


Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn 
385                 390                 395                 400 


Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val 
                405                 410                 415     


Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile 
            420                 425                 430         


Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe 
        435                 440                 445             


Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile 
    450                 455                 460                 


Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu 
465                 470                 475                 480 


Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe 
                485                 490                 495     


Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe 
            500                 505                 510         


Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg 
        515                 520                 525             


Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu 
    530                 535                 540                 


Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe 
545                 550                 555                 560 


Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly 
                565                 570                 575     


Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile 
            580                 585                 590         


His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg 
        595                 600                 605             


Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln 
    610                 615                 620                 


Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile 
625                 630                 635                 640 


Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu 
                645                 650                 655     


Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn 
            660                 665                 670         


Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser 
        675                 680                 685             


Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn 
    690                 695                 700                 


Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu 
705                 710                 715                 720 


Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln 
                725                 730                 735     


Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln 
            740                 745                 750         


Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr 
        755                 760                 765             


Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys 
    770                 775                 780                 


Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn 
785                 790                 795                 800 


Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu 
                805                 810                 815     


Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser 
            820                 825                 830         


Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp 
        835                 840                 845             


Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp 
    850                 855                 860                 


Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe 
865                 870                 875                 880 


Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val 
                885                 890                 895     


Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu 
            900                 905                 910         


Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr 
        915                 920                 925             


Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr 
    930                 935                 940                 


Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg 
945                 950                 955                 960 


Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys 
                965                 970                 975     


Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn 
            980                 985                 990         


Pro Asp Asn Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
        995                 1000                 1005             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1010                 1015                 1020             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1025                 1030                 1035             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1040                 1045                 1050             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1055                 1060                 1065             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1070                 1075                 1080             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1085                 1090                 1095             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1100                 1105                 1110             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1115                 1120                 1125             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1130                 1135                 1140             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1145                 1150                 1155             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1160                 1165                 1170             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1175                 1180                 1185             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1190                 1195                 1200             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1205                 1210                 1215             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1220                 1225                 1230             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1235                 1240                 1245             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1250                 1255                 1260             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1265                 1270                 1275             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1280                 1285                 1290             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1295                 1300                 1305             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1310                 1315                 1320             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1325                 1330                 1335             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1340                 1345                 1350             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1355                 1360                 1365             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1370                 1375                 1380             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1385                 1390                 1395             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1400                 1405                 1410             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1415                 1420                 1425             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1430                 1435                 1440             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1445                 1450                 1455             


Lys Val  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1460                 1465                 1470             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1475                 1480                 1485             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1490                 1495                 1500             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1505                 1510                 1515             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1520                 1525                 1530             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1535                 1540                 1545             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1550                 1555             


<210>  48
<211>  1558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Met Pro Lys Lys Lys Arg Lys Val Met Glu Ala Ser Pro Ala Ser Gly 
1               5                   10                  15      


Pro Arg His Leu Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn 
            20                  25                  30          


Gly Ile Gly Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu 
        35                  40                  45              


Asp Asn Gly Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His 
    50                  55                  60                  


Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu 
65                  70                  75                  80  


Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln 
                85                  90                  95      


Ile Tyr Arg Val Thr Trp Phe Ile Ser Tyr Ser Pro Cys Phe Ser Ala 
            100                 105                 110         


Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val 
        115                 120                 125             


Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Asp Asp Pro Leu Tyr 
    130                 135                 140                 


Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile 
145                 150                 155                 160 


Met Thr Tyr Asp Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His 
                165                 170                 175     


Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
            180                 185                 190         


Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser 
        195                 200                 205             


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met 
    210                 215                 220                 


Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu 
225                 230                 235                 240 


Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn 
                245                 250                 255     


Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly 
            260                 265                 270         


Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val 
        275                 280                 285             


Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe 
    290                 295                 300                 


Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu 
305                 310                 315                 320 


Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu 
                325                 330                 335     


Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro 
            340                 345                 350         


Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn 
        355                 360                 365             


Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met 
    370                 375                 380                 


Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn 
385                 390                 395                 400 


Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val 
                405                 410                 415     


Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile 
            420                 425                 430         


Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe 
        435                 440                 445             


Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile 
    450                 455                 460                 


Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu 
465                 470                 475                 480 


Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe 
                485                 490                 495     


Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe 
            500                 505                 510         


Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg 
        515                 520                 525             


Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu 
    530                 535                 540                 


Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe 
545                 550                 555                 560 


Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly 
                565                 570                 575     


Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile 
            580                 585                 590         


His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg 
        595                 600                 605             


Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln 
    610                 615                 620                 


Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile 
625                 630                 635                 640 


Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu 
                645                 650                 655     


Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn 
            660                 665                 670         


Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser 
        675                 680                 685             


Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn 
    690                 695                 700                 


Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu 
705                 710                 715                 720 


Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln 
                725                 730                 735     


Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln 
            740                 745                 750         


Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr 
        755                 760                 765             


Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys 
    770                 775                 780                 


Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn 
785                 790                 795                 800 


Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu 
                805                 810                 815     


Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser 
            820                 825                 830         


Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp 
        835                 840                 845             


Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp 
    850                 855                 860                 


Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe 
865                 870                 875                 880 


Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val 
                885                 890                 895     


Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu 
            900                 905                 910         


Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr 
        915                 920                 925             


Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr 
    930                 935                 940                 


Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg 
945                 950                 955                 960 


Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys 
                965                 970                 975     


Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn 
            980                 985                 990         


Pro Asp Asn Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
        995                 1000                 1005             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1010                 1015                 1020             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1025                 1030                 1035             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1040                 1045                 1050             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1055                 1060                 1065             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1070                 1075                 1080             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1085                 1090                 1095             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1100                 1105                 1110             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1115                 1120                 1125             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1130                 1135                 1140             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1145                 1150                 1155             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1160                 1165                 1170             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1175                 1180                 1185             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1190                 1195                 1200             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1205                 1210                 1215             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1220                 1225                 1230             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1235                 1240                 1245             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1250                 1255                 1260             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1265                 1270                 1275             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1280                 1285                 1290             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1295                 1300                 1305             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1310                 1315                 1320             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1325                 1330                 1335             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1340                 1345                 1350             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1355                 1360                 1365             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1370                 1375                 1380             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1385                 1390                 1395             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1400                 1405                 1410             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1415                 1420                 1425             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1430                 1435                 1440             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1445                 1450                 1455             


Lys Val  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1460                 1465                 1470             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1475                 1480                 1485             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1490                 1495                 1500             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1505                 1510                 1515             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1520                 1525                 1530             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1535                 1540                 1545             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1550                 1555             


<210>  49
<211>  1558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Met Pro Lys Lys Lys Arg Lys Val Met Glu Ala Ser Pro Ala Ser Gly 
1               5                   10                  15      


Pro Arg His Leu Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn 
            20                  25                  30          


Gly Ile Gly Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu 
        35                  40                  45              


Asp Asn Gly Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His 
    50                  55                  60                  


Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu 
65                  70                  75                  80  


Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln 
                85                  90                  95      


Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Ala 
            100                 105                 110         


Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val 
        115                 120                 125             


Arg Leu Arg Ile Phe Ala Ala Arg Ile Phe Asp Tyr Asp Tyr Leu Tyr 
    130                 135                 140                 


Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile 
145                 150                 155                 160 


Met Thr Tyr Asp Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His 
                165                 170                 175     


Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
            180                 185                 190         


Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser 
        195                 200                 205             


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met 
    210                 215                 220                 


Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu 
225                 230                 235                 240 


Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn 
                245                 250                 255     


Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly 
            260                 265                 270         


Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val 
        275                 280                 285             


Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe 
    290                 295                 300                 


Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu 
305                 310                 315                 320 


Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu 
                325                 330                 335     


Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro 
            340                 345                 350         


Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn 
        355                 360                 365             


Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met 
    370                 375                 380                 


Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn 
385                 390                 395                 400 


Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val 
                405                 410                 415     


Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile 
            420                 425                 430         


Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe 
        435                 440                 445             


Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile 
    450                 455                 460                 


Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu 
465                 470                 475                 480 


Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe 
                485                 490                 495     


Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe 
            500                 505                 510         


Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg 
        515                 520                 525             


Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu 
    530                 535                 540                 


Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe 
545                 550                 555                 560 


Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly 
                565                 570                 575     


Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile 
            580                 585                 590         


His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg 
        595                 600                 605             


Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln 
    610                 615                 620                 


Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile 
625                 630                 635                 640 


Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu 
                645                 650                 655     


Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn 
            660                 665                 670         


Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser 
        675                 680                 685             


Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn 
    690                 695                 700                 


Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu 
705                 710                 715                 720 


Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln 
                725                 730                 735     


Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln 
            740                 745                 750         


Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr 
        755                 760                 765             


Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys 
    770                 775                 780                 


Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn 
785                 790                 795                 800 


Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu 
                805                 810                 815     


Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser 
            820                 825                 830         


Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp 
        835                 840                 845             


Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp 
    850                 855                 860                 


Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe 
865                 870                 875                 880 


Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val 
                885                 890                 895     


Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu 
            900                 905                 910         


Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr 
        915                 920                 925             


Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr 
    930                 935                 940                 


Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg 
945                 950                 955                 960 


Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys 
                965                 970                 975     


Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn 
            980                 985                 990         


Pro Asp Asn Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
        995                 1000                 1005             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1010                 1015                 1020             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1025                 1030                 1035             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1040                 1045                 1050             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1055                 1060                 1065             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1070                 1075                 1080             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1085                 1090                 1095             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1100                 1105                 1110             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1115                 1120                 1125             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1130                 1135                 1140             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1145                 1150                 1155             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1160                 1165                 1170             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1175                 1180                 1185             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1190                 1195                 1200             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1205                 1210                 1215             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1220                 1225                 1230             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1235                 1240                 1245             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1250                 1255                 1260             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1265                 1270                 1275             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1280                 1285                 1290             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1295                 1300                 1305             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1310                 1315                 1320             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1325                 1330                 1335             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1340                 1345                 1350             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1355                 1360                 1365             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1370                 1375                 1380             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1385                 1390                 1395             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1400                 1405                 1410             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1415                 1420                 1425             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1430                 1435                 1440             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1445                 1450                 1455             


Lys Val  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1460                 1465                 1470             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1475                 1480                 1485             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1490                 1495                 1500             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1505                 1510                 1515             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1520                 1525                 1530             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1535                 1540                 1545             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1550                 1555             


<210>  50
<211>  1558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Met Pro Lys Lys Lys Arg Lys Val Met Glu Ala Ser Pro Ala Ser Gly 
1               5                   10                  15      


Pro Arg His Leu Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn 
            20                  25                  30          


Gly Ile Gly Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu 
        35                  40                  45              


Asp Asn Gly Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His 
    50                  55                  60                  


Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu 
65                  70                  75                  80  


Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln 
                85                  90                  95      


Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Ala 
            100                 105                 110         


Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val 
        115                 120                 125             


Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp Asp Asp Tyr Leu Tyr 
    130                 135                 140                 


Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile 
145                 150                 155                 160 


Met Thr Tyr Asp Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His 
                165                 170                 175     


Gln Gly Cys Pro Phe Gln Pro Trp Asp Gly Leu Asp Glu His Ser Gln 
            180                 185                 190         


Ala Leu Ser Gly Arg Leu Arg Ala Ile Leu Gln Asn Gln Gly Asn Ser 
        195                 200                 205             


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met 
    210                 215                 220                 


Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu 
225                 230                 235                 240 


Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn 
                245                 250                 255     


Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly 
            260                 265                 270         


Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val 
        275                 280                 285             


Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe 
    290                 295                 300                 


Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu 
305                 310                 315                 320 


Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu 
                325                 330                 335     


Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro 
            340                 345                 350         


Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn 
        355                 360                 365             


Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met 
    370                 375                 380                 


Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn 
385                 390                 395                 400 


Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val 
                405                 410                 415     


Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile 
            420                 425                 430         


Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe 
        435                 440                 445             


Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile 
    450                 455                 460                 


Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu 
465                 470                 475                 480 


Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe 
                485                 490                 495     


Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe 
            500                 505                 510         


Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg 
        515                 520                 525             


Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu 
    530                 535                 540                 


Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe 
545                 550                 555                 560 


Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly 
                565                 570                 575     


Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile 
            580                 585                 590         


His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg 
        595                 600                 605             


Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln 
    610                 615                 620                 


Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile 
625                 630                 635                 640 


Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu 
                645                 650                 655     


Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn 
            660                 665                 670         


Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser 
        675                 680                 685             


Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn 
    690                 695                 700                 


Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu 
705                 710                 715                 720 


Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln 
                725                 730                 735     


Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln 
            740                 745                 750         


Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr 
        755                 760                 765             


Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys 
    770                 775                 780                 


Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn 
785                 790                 795                 800 


Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu 
                805                 810                 815     


Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser 
            820                 825                 830         


Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp 
        835                 840                 845             


Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp 
    850                 855                 860                 


Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe 
865                 870                 875                 880 


Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val 
                885                 890                 895     


Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu 
            900                 905                 910         


Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr 
        915                 920                 925             


Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr 
    930                 935                 940                 


Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg 
945                 950                 955                 960 


Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys 
                965                 970                 975     


Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn 
            980                 985                 990         


Pro Asp Asn Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
        995                 1000                 1005             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1010                 1015                 1020             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1025                 1030                 1035             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1040                 1045                 1050             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1055                 1060                 1065             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1070                 1075                 1080             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1085                 1090                 1095             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1100                 1105                 1110             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1115                 1120                 1125             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1130                 1135                 1140             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1145                 1150                 1155             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1160                 1165                 1170             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1175                 1180                 1185             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1190                 1195                 1200             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1205                 1210                 1215             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1220                 1225                 1230             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1235                 1240                 1245             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1250                 1255                 1260             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1265                 1270                 1275             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1280                 1285                 1290             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1295                 1300                 1305             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1310                 1315                 1320             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1325                 1330                 1335             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1340                 1345                 1350             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1355                 1360                 1365             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1370                 1375                 1380             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1385                 1390                 1395             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1400                 1405                 1410             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1415                 1420                 1425             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1430                 1435                 1440             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1445                 1450                 1455             


Lys Val  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1460                 1465                 1470             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1475                 1480                 1485             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1490                 1495                 1500             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1505                 1510                 1515             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1520                 1525                 1530             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1535                 1540                 1545             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1550                 1555             


