                               SEQUENCE LISTING

<110> ENDOCYTE, INC.
      PURDUE RESEARCH FOUNDATION
      SEATTLE CHILDREN'S HOSPITAL (DBA SEATTLE CHILDREN'S
      RESEARCH INSTITUTE)
 
<120> SEQUENCING METHOD FOR CAR T CELL THERAPY

<130> 20150-291690

<140> PCT/US2019/019191
<141> 2019-02-22

<150> 62/736,730
<151> 2018-09-26

<150> 62/724,345
<151> 2018-08-29

<150> 62/656,265
<151> 2018-04-11

<150> 62/634,573
<151> 2018-02-23

<160> 11    

<170> PatentIn version 3.5

<210> 1
<211> 1554
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggatgtcg tgatgaccca gacccccctc agcctcccag tgtccctcgg tgaccaggct      120

tctattagtt gcagatccag ccagtccctc gtgcactcta acggtaatac ctacctgaga      180

tggtatctcc agaagcccgg acagagccct aaggtgctga tctacaaagt ctccaaccgg      240

gtgtctggag tccctgaccg cttctcaggg agcggttccg gcaccgactt caccctgaag      300

atcaaccggg tggaggccga agacctcggc gtctatttct gctctcagag tacacatgtg      360

ccctggacct tcggcggagg gaccaagctg gagatcaaaa gctccgcaga cgatgccaag      420

aaagatgccg ctaagaaaga cgatgctaag aaagacgatg caaagaaaga cggtggcgtg      480

aagctggatg aaaccggagg aggtctcgtc cagccaggag gagccatgaa gctgagttgc      540

gtgaccagcg gattcacctt tgggcactac tggatgaact gggtgcgaca gtccccagag      600

aaggggctcg aatgggtcgc tcagttcagg aacaaaccct acaattatga gacatactat      660

tcagacagcg tgaagggcag gtttactatc agtagagacg attccaaatc tagcgtgtac      720

ctgcagatga acaatctcag ggtcgaagat acaggcatct actattgcac aggggcatcc      780

tatggtatgg agtatctcgg tcaggggaca agcgtcacag tcagtttcgt gccggtcttc      840

ctgccagcga agcccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      900

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      960

cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact     1020

tgtggggtcc ttctcctgtc actggttatc accctttact gcaaccacag gaaccgtttc     1080

tctgttgtta aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1140

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1200

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1260

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1320

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1380

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1440

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1500

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1554


<210> 2
<211> 517
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Ser Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala 
    130                 135                 140                 


Lys Lys Asp Asp Ala Lys Lys Asp Asp Ala Lys Lys Asp Gly Gly Val 
145                 150                 155                 160 


Lys Leu Asp Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ala Met 
                165                 170                 175     


Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Gly His Tyr Trp Met 
            180                 185                 190         


Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala Gln 
        195                 200                 205             


Phe Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr Tyr Cys 
                245                 250                 255     


Thr Gly Ala Ser Tyr Gly Met Glu Tyr Leu Gly Gln Gly Thr Ser Val 
            260                 265                 270         


Thr Val Ser Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr 
        275                 280                 285             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    290                 295                 300                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
305                 310                 315                 320 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                325                 330                 335     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            340                 345                 350         


Tyr Cys Asn His Arg Asn Arg Phe Ser Val Val Lys Arg Gly Arg Lys 
        355                 360                 365             


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
    370                 375                 380                 


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
385                 390                 395                 400 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                405                 410                 415     


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            420                 425                 430         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        435                 440                 445             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    450                 455                 460                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
465                 470                 475                 480 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                485                 490                 495     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            500                 505                 510         


Ala Leu Pro Pro Arg 
        515         


<210> 3
<211> 1560
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
gccaccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc       60

gccaggccgg atgtcgtgat gacccagacc cccctcagcc tcccagtgtc cctcggtgac      120

caggcttcta ttagttgcag atccagccag tccctcgtgc actctaacgg taatacctac      180

ctgagatggt atctccagaa gcccggacag agccctaagg tgctgatcta caaagtctcc      240

aaccgggtgt ctggagtccc tgaccgcttc tcagggagcg gttccggcac cgacttcacc      300

ctgaagatca accgggtgga ggccgaagac ctcggcgtct atttctgctc tcagagtaca      360

catgtgccct ggaccttcgg cggagggacc aagctggaga tcaaaagctc cgcagacgat      420

gccaagaaag atgccgctaa gaaagacgat gctaagaaag acgatgcaaa gaaagacggt      480

ggcgtgaagc tggatgaaac cggaggaggt ctcgtccagc caggaggagc catgaagctg      540

agttgcgtga ccagcggatt cacctttggg cactactgga tgaactgggt gcgacagtcc      600

ccagagaagg ggctcgaatg ggtcgctcag ttcaggaaca aaccctacaa ttatgagaca      660

tactattcag acagcgtgaa gggcaggttt actatcagta gagacgattc caaatctagc      720

gtgtacctgc agatgaacaa tctcagggtc gaagatacag gcatctacta ttgcacaggg      780

gcatcctatg gtatggagta tctcggtcag gggacaagcg tcacagtcag tttcgtgccg      840

gtcttcctgc cagcgaagcc caccacgacg ccagcgccgc gaccaccaac accggcgccc      900

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      960

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc     1020

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa ccacaggaac     1080

cgtttctctg ttgttaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt     1140

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa     1200

gaagaaggag gatgtgaact gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1260

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1320

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1380

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1440

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1500

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa     1560


<210> 4
<211> 2052
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
agcgtgctga cacagcctag ctccgtgtct gccgcccctg gccagaaagt gaccatcagc       60

tgtagcggca gcaccagcaa catcggcaac aactacgtgt cctggtatca gcagcacccc      120

ggcaaggccc ccaagctgat gatctacgac gtgtccaagc ggcccagcgg cgtgcccgat      180

agattttccg gcagcaagag cggcaacagc gccagcctgg atatcagcgg cctgcagtct      240

gaggacgagg ccgactacta ttgcgccgcc tgggacgata gcctgagcga gttcctgttt      300

ggcaccggca ccaagctgac agtgctgggc ggaggcggag gatctggcgg cggaggaagt      360

ggcggagggg gatctcaggt gcagctggtg gaaagcggcg gcaacctggt gcagcctggc      420

ggatctctga gactgagctg tgccgccagc ggcttcacct tcggcagctt cagcatgagc      480

tgggtgcgcc aggctcctgg gggaggactg gaatgggtgg caggactgag cgccagaagc      540

agcctgaccc actacgccga tagcgtgaag ggccggttca ccatcagccg ggacaacgcc      600

aagaacagcg tgtacctgca gatgaacagc ctgcgggtgg aagataccgc cgtgtactac      660

tgcgccagac ggtcctacga cagcagcggc tactggggcc acttctacag ctacatggac      720

gtgtggggcc agggcaccct cgtgacagtg tctgagagca agtacggacc gccctgcccc      780

ccttgccctg cccccgagtt cgacggcgga cccagcgtgt tcctgttccc ccccaagccc      840

aaggacaccc tgatgatcag ccggaccccc gaggtgacct gcgtggtggt ggacgtgagc      900

caggaagatc ccgaggtcca gttcaattgg tacgtggacg gcgtggaagt gcacaacgcc      960

aagaccaagc ccagagagga acagttccag agcacctacc gggtggtgtc tgtgctgacc     1020

gtgctgcacc aggactggct gaacggcaaa gaatacaagt gcaaggtgtc caacaagggc     1080

ctgcccagca gcatcgaaaa gaccatcagc aaggccaagg gccagcctcg cgagccccag     1140

gtgtacaccc tgcctccctc ccaggaagag atgaccaaga accaggtgtc cctgacctgc     1200

ctggtgaagg gcttctaccc cagcgacatc gccgtggagt gggagagcaa cggccagcct     1260

gagaacaact acaagaccac ccctcccgtg ctggacagcg acggcagctt cttcctgtac     1320

agccggctga ccgtggacaa gagccggtgg caggaaggca acgtctttag ctgcagcgtg     1380

atgcacgagg ccctgcacaa ccactacacc cagaagagcc tgagcctgtc cctgggcaag     1440

atgttctggg tgctggtggt ggtgggcggg gtgctggcct gctacagcct gctggtgaca     1500

gtggccttca tcatcttttg ggtgaaacgg ggcagaaaga aactcctgta tatattcaaa     1560

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt     1620

ccagaagaag aagaaggagg atgtgaactg cgggtgaagt tcagcagaag cgccgacgcc     1680

cctgcctacc agcagggcca gaatcagctg tacaacgagc tgaacctggg cagaagggaa     1740

gagtacgacg tcctggataa gcggagaggc cgggaccctg agatgggcgg caagcctcgg     1800

cggaagaacc cccaggaagg cctgtataac gaactgcaga aagacaagat ggccgaggcc     1860

tacagcgaga tcggcatgaa gggcgagcgg aggcggggca agggccacga cggcctgtat     1920

cagggcctgt ccaccgccac caaggatacc tacgacgccc tgcacatgca ggccctgccc     1980

ccaaggctcg agggcggcgg agagggcaga ggaagtcttc taacatgcgg tgacgtggag     2040

gagaatcccg gc                                                         2052


<210> 5
<211> 684
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Ser Val Leu Thr Gln Pro Ser Ser Val Ser Ala Ala Pro Gly Gln Lys 
1               5                   10                  15      


Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Lys Ser Gly Asn Ser Ala Ser Leu Asp Ile Ser Gly Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser 
                85                  90                  95      


Glu Phe Leu Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Asn Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe Ser Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val Ala Gly Leu 
                165                 170                 175     


Ser Ala Arg Ser Ser Leu Thr His Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg 
    210                 215                 220                 


Ser Tyr Asp Ser Ser Gly Tyr Trp Gly His Phe Tyr Ser Tyr Met Asp 
225                 230                 235                 240 


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Glu Ser Lys Tyr Gly 
                245                 250                 255     


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Asp Gly Gly Pro Ser 
            260                 265                 270         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        275                 280                 285             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
    290                 295                 300                 


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
305                 310                 315                 320 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val 
                325                 330                 335     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            340                 345                 350         


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
        355                 360                 365             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    370                 375                 380                 


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
385                 390                 395                 400 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                405                 410                 415     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            420                 425                 430         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
        435                 440                 445             


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    450                 455                 460                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
465                 470                 475                 480 


Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
                485                 490                 495     


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
            500                 505                 510         


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
        515                 520                 525             


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
    530                 535                 540                 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
545                 550                 555                 560 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                565                 570                 575     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            580                 585                 590         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        595                 600                 605             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    610                 615                 620                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
625                 630                 635                 640 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                645                 650                 655     


Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser 
            660                 665                 670         


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
        675                 680                 


<210> 6
<211> 2061
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
gacgttgtaa tgacccagac ccctctgtct ctccccgtaa gcttgggcga ccaggcgagc       60

atctcttgtc ggtcttccca gtccctggtc cattcaaacg gcaatactta cttgcggtgg      120

tacttgcaga agcccggtca atccccaaaa gtgctgatat acaaggttag caatcgggtc      180

agtggagtgc ccgaccgctt cagcggaagc ggatccggga ctgacttcac tctgaagatc      240

aaccgggtag aagctgaaga cctgggggtg tacttctgct ctcagtcaac acacgtgcca      300

tggacctttg gaggtggcac caagctggaa atcaaatcat cagcggacga tgccaaaaaa      360

gacgcggcca agaaggacga tgccaagaag gatgatgcta aaaaggatgg cggagtcaaa      420

ttggacgaga caggcggggg actggtgcag cccggcggtg ccatgaaact gtcttgtgtg      480

accagcggct ttaccttcgg gcattattgg atgaactggg tgcgacagtc tccagagaaa      540

gggctcgagt gggtggccca gtttcgaaat aaaccgtaca attatgagac ctactattca      600

gattctgtga aagggcgctt cactatttca cgcgacgaca gcaaaagttc cgtctacctt      660

cagatgaaca accttagagt ggaggatacc ggaatatact actgcacggg tgccagttat      720

ggcatggagt acttggggca ggggacatct gtgaccgttt ctgagagcaa gtacggaccg      780

ccctgccccc cttgccctgc ccccgagttc gacggcggac ccagcgtgtt cctgttcccc      840

cccaagccca aggacaccct gatgatcagc cggacccccg aggtgacctg cgtggtggtg      900

gacgtgagcc aggaagatcc cgaggtccag ttcaattggt acgtggacgg cgtggaagtg      960

cacaacgcca agaccaagcc cagagaggaa cagttccaga gcacctaccg ggtggtgtct     1020

gtgctgaccg tgctgcacca ggactggctg aacggcaaag aatacaagtg caaggtgtcc     1080

aacaagggcc tgcccagcag catcgaaaag accatcagca aggccaaggg ccagcctcgc     1140

gagccccagg tgtacaccct gcctccctcc caggaagaga tgaccaagaa ccaggtgtcc     1200

ctgacctgcc tggtgaaggg cttctacccc agcgacatcg ccgtggagtg ggagagcaac     1260

ggccagcctg agaacaacta caagaccacc cctcccgtgc tggacagcga cggcagcttc     1320

ttcctgtaca gccggctgac cgtggacaag agccggtggc aggaaggcaa cgtctttagc     1380

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct gagcctgtcc     1440

ctgggcaaga tgttctgggt gctggtggtg gtgggcgggg tgctggcctg ctacagcctg     1500

ctggtgacag tggccttcat catcttttgg gtgaaacggg gcagaaagaa actcctgtat     1560

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1620

tgccgatttc cagaagaaga agaaggagga tgtgaactgc gggtgaagtt cagcagaagc     1680

gccgacgccc ctgcctacca gcagggccag aatcagctgt acaacgagct gaacctgggc     1740

agaagggaag agtacgacgt cctggataag cggagaggcc gggaccctga gatgggcggc     1800

aagcctcggc ggaagaaccc ccaggaaggc ctgtataacg aactgcagaa agacaagatg     1860

gccgaggcct acagcgagat cggcatgaag ggcgagcgga ggcggggcaa gggccacgac     1920

ggcctgtatc agggcctgtc caccgccacc aaggatacct acgacgccct gcacatgcag     1980

gccctgcccc caaggctcga gggcggcgga gagggcagag gaagtcttct aacatgcggt     2040

gacgtggagg agaatcccgg c                                               2061


<210> 7
<211> 687
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Ser Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Asp Ala 
        115                 120                 125             


Lys Lys Asp Asp Ala Lys Lys Asp Gly Gly Val Lys Leu Asp Glu Thr 
    130                 135                 140                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ala Met Lys Leu Ser Cys Val 
145                 150                 155                 160 


Thr Ser Gly Phe Thr Phe Gly His Tyr Trp Met Asn Trp Val Arg Gln 
                165                 170                 175     


Ser Pro Glu Lys Gly Leu Glu Trp Val Ala Gln Phe Arg Asn Lys Pro 
            180                 185                 190         


Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr 
        195                 200                 205             


Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met Asn Asn 
    210                 215                 220                 


Leu Arg Val Glu Asp Thr Gly Ile Tyr Tyr Cys Thr Gly Ala Ser Tyr 
225                 230                 235                 240 


Gly Met Glu Tyr Leu Gly Gln Gly Thr Ser Val Thr Val Ser Glu Ser 
                245                 250                 255     


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Asp Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
    290                 295                 300                 


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Leu Gly Lys Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
                485                 490                 495     


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
            500                 505                 510         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        515                 520                 525             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    530                 535                 540                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
545                 550                 555                 560 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                565                 570                 575     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            580                 585                 590         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        595                 600                 605             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    610                 615                 620                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
625                 630                 635                 640 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                645                 650                 655     


Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly 
            660                 665                 670         


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
        675                 680                 685         


<210> 8
<211> 3198
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccaagcg tgctgacaca gcctagctcc gtgtctgccg cccctggcca gaaagtgacc      120

atcagctgta gcggcagcac cagcaacatc ggcaacaact acgtgtcctg gtatcagcag      180

caccccggca aggcccccaa gctgatgatc tacgacgtgt ccaagcggcc cagcggcgtg      240

cccgatagat tttccggcag caagagcggc aacagcgcca gcctggatat cagcggcctg      300

cagtctgagg acgaggccga ctactattgc gccgcctggg acgatagcct gagcgagttc      360

ctgtttggca ccggcaccaa gctgacagtg ctgggcggag gcggaggatc tggcggcgga      420

ggaagtggcg gagggggatc tcaggtgcag ctggtggaaa gcggcggcaa cctggtgcag      480

cctggcggat ctctgagact gagctgtgcc gccagcggct tcaccttcgg cagcttcagc      540

atgagctggg tgcgccaggc tcctggggga ggactggaat gggtggcagg actgagcgcc      600

agaagcagcc tgacccacta cgccgatagc gtgaagggcc ggttcaccat cagccgggac      660

aacgccaaga acagcgtgta cctgcagatg aacagcctgc gggtggaaga taccgccgtg      720

tactactgcg ccagacggtc ctacgacagc agcggctact ggggccactt ctacagctac      780

atggacgtgt ggggccaggg caccctcgtg acagtgtctg agagcaagta cggaccgccc      840

tgcccccctt gccctgcccc cgagttcgac ggcggaccca gcgtgttcct gttccccccc      900

aagcccaagg acaccctgat gatcagccgg acccccgagg tgacctgcgt ggtggtggac      960

gtgagccagg aagatcccga ggtccagttc aattggtacg tggacggcgt ggaagtgcac     1020

aacgccaaga ccaagcccag agaggaacag ttccagagca cctaccgggt ggtgtctgtg     1080

ctgaccgtgc tgcaccagga ctggctgaac ggcaaagaat acaagtgcaa ggtgtccaac     1140

aagggcctgc ccagcagcat cgaaaagacc atcagcaagg ccaagggcca gcctcgcgag     1200

ccccaggtgt acaccctgcc tccctcccag gaagagatga ccaagaacca ggtgtccctg     1260

acctgcctgg tgaagggctt ctaccccagc gacatcgccg tggagtggga gagcaacggc     1320

cagcctgaga acaactacaa gaccacccct cccgtgctgg acagcgacgg cagcttcttc     1380

ctgtacagcc ggctgaccgt ggacaagagc cggtggcagg aaggcaacgt ctttagctgc     1440

agcgtgatgc acgaggccct gcacaaccac tacacccaga agagcctgag cctgtccctg     1500

ggcaagatgt tctgggtgct ggtggtggtg ggcggggtgc tggcctgcta cagcctgctg     1560

gtgacagtgg ccttcatcat cttttgggtg aaacggggca gaaagaaact cctgtatata     1620

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1680

cgatttccag aagaagaaga aggaggatgt gaactgcggg tgaagttcag cagaagcgcc     1740

gacgcccctg cctaccagca gggccagaat cagctgtaca acgagctgaa cctgggcaga     1800

agggaagagt acgacgtcct ggataagcgg agaggccggg accctgagat gggcggcaag     1860

cctcggcgga agaaccccca ggaaggcctg tataacgaac tgcagaaaga caagatggcc     1920

gaggcctaca gcgagatcgg catgaagggc gagcggaggc ggggcaaggg ccacgacggc     1980

ctgtatcagg gcctgtccac cgccaccaag gatacctacg acgccctgca catgcaggcc     2040

ctgcccccaa ggctcgaggg cggcggagag ggcagaggaa gtcttctaac atgcggtgac     2100

gtggaggaga atcccggccc taggatgctt ctcctggtga caagccttct gctctgtgag     2160

ttaccacacc cagcattcct cctgatccca cgcaaagtgt gtaacggaat aggtattggt     2220

gaatttaaag actcactctc cataaatgct acgaatatta aacacttcaa aaactgcacc     2280

tccatcagtg gcgatctcca catcctgccg gtggcattta ggggtgactc cttcacacat     2340

actcctcctc tggatccaca ggaactggat attctgaaaa ccgtaaagga aatcacaggg     2400

tttttgctga ttcaggcttg gcctgaaaac aggacggacc tccatgcctt tgagaaccta     2460

gaaatcatac gcggcaggac caagcaacat ggtcagtttt ctcttgcagt cgtcagcctg     2520

aacataacat ccttgggatt acgctccctc aaggagataa gtgatggaga tgtgataatt     2580

tcaggaaaca aaaatttgtg ctatgcaaat acaataaact ggaaaaaact gtttgggacc     2640

tccggtcaga aaaccaaaat tataagcaac agaggtgaaa acagctgcaa ggccacaggc     2700

caggtctgcc atgccttgtg ctcccccgag ggctgctggg gcccggagcc cagggactgc     2760

gtctcttgcc ggaatgtcag ccgaggcagg gaatgcgtgg acaagtgcaa ccttctggag     2820

ggtgagccaa gggagtttgt ggagaactct gagtgcatac agtgccaccc agagtgcctg     2880

cctcaggcca tgaacatcac ctgcacagga cggggaccag acaactgtat ccagtgtgcc     2940

cactacattg acggccccca ctgcgtcaag acctgcccgg caggagtcat gggagaaaac     3000

aacaccctgg tctggaagta cgcagacgcc ggccatgtgt gccacctgtg ccatccaaac     3060

tgcacctacg gatgcactgg gccaggtctt gaaggctgtc caacgaatgg gcctaagatc     3120

ccgtccatcg ccactgggat ggtgggggcc ctcctcttgc tgctggtggt ggccctgggg     3180

atcggcctct tcatgtga                                                   3198


<210> 9
<211> 1065
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Ser Val Leu Thr Gln Pro Ser Ser Val Ser 
            20                  25                  30          


Ala Ala Pro Gly Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Thr Ser 
        35                  40                  45              


Asn Ile Gly Asn Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Asp 
                85                  90                  95      


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala 
            100                 105                 110         


Trp Asp Asp Ser Leu Ser Glu Phe Leu Phe Gly Thr Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln 
145                 150                 155                 160 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                165                 170                 175     


Gly Ser Phe Ser Met Ser Trp Val Arg Gln Ala Pro Gly Gly Gly Leu 
            180                 185                 190         


Glu Trp Val Ala Gly Leu Ser Ala Arg Ser Ser Leu Thr His Tyr Ala 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Arg Ser Tyr Asp Ser Ser Gly Tyr Trp Gly His 
                245                 250                 255     


Phe Tyr Ser Tyr Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
        275                 280                 285             


Phe Asp Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    290                 295                 300                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
305                 310                 315                 320 


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
                325                 330                 335     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln 
            340                 345                 350         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        355                 360                 365             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
    370                 375                 380                 


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
385                 390                 395                 400 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
                405                 410                 415     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            420                 425                 430         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        435                 440                 445             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
    450                 455                 460                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
465                 470                 475                 480 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                485                 490                 495     


Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val Val Gly Gly 
            500                 505                 510         


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
        515                 520                 525             


Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    530                 535                 540                 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
545                 550                 555                 560 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                565                 570                 575     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            580                 585                 590         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        595                 600                 605             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    610                 615                 620                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
625                 630                 635                 640 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                645                 650                 655     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            660                 665                 670         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly 
        675                 680                 685             


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
    690                 695                 700                 


Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu 
705                 710                 715                 720 


Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly 
                725                 730                 735     


Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn 
            740                 745                 750         


Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile 
        755                 760                 765             


Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu 
    770                 775                 780                 


Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly 
785                 790                 795                 800 


Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala 
                805                 810                 815     


Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln 
            820                 825                 830         


Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg 
        835                 840                 845             


Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys 
    850                 855                 860                 


Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr 
865                 870                 875                 880 


Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys 
                885                 890                 895     


Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys 
            900                 905                 910         


Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg 
        915                 920                 925             


Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg 
    930                 935                 940                 


Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu 
945                 950                 955                 960 


Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys 
                965                 970                 975     


Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys 
            980                 985                 990         


Pro Ala Gly Val Met Gly Glu Asn  Asn Thr Leu Val Trp  Lys Tyr Ala 
        995                 1000                 1005             


Asp Ala  Gly His Val Cys His  Leu Cys His Pro Asn  Cys Thr Tyr 
    1010                 1015                 1020             


Gly Cys  Thr Gly Pro Gly Leu  Glu Gly Cys Pro Thr  Asn Gly Pro 
    1025                 1030                 1035             


Lys Ile  Pro Ser Ile Ala Thr  Gly Met Val Gly Ala  Leu Leu Leu 
    1040                 1045                 1050             


Leu Leu  Val Val Ala Leu Gly  Ile Gly Leu Phe Met  
    1055                 1060                 1065 


<210> 10
<211> 1068
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Val Val Met Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Lys Val Ser Asn 
65                  70                  75                  80  


Arg Val Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Asn Arg Val Glu Ala Glu Asp Leu Gly Val 
            100                 105                 110         


Tyr Phe Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Ser Ser Ala Asp Asp Ala Lys Lys Asp Ala 
    130                 135                 140                 


Ala Lys Lys Asp Asp Ala Lys Lys Asp Asp Ala Lys Lys Asp Gly Gly 
145                 150                 155                 160 


Val Lys Leu Asp Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ala 
                165                 170                 175     


Met Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Gly His Tyr Trp 
            180                 185                 190         


Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala 
        195                 200                 205             


Gln Phe Arg Asn Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser 
    210                 215                 220                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr Tyr 
                245                 250                 255     


Cys Thr Gly Ala Ser Tyr Gly Met Glu Tyr Leu Gly Gln Gly Thr Ser 
            260                 265                 270         


Val Thr Val Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
        275                 280                 285             


Ala Pro Glu Phe Asp Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    290                 295                 300                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
305                 310                 315                 320 


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
                325                 330                 335     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            340                 345                 350         


Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        355                 360                 365             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    370                 375                 380                 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
385                 390                 395                 400 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
                405                 410                 415     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            420                 425                 430         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        435                 440                 445             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    450                 455                 460                 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
465                 470                 475                 480 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                485                 490                 495     


Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val 
            500                 505                 510         


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
        515                 520                 525             


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    530                 535                 540                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
545                 550                 555                 560 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                565                 570                 575     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            580                 585                 590         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        595                 600                 605             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    610                 615                 620                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
625                 630                 635                 640 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                645                 650                 655     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            660                 665                 670         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu 
        675                 680                 685             


Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
    690                 695                 700                 


Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu 
705                 710                 715                 720 


Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val 
                725                 730                 735     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            740                 745                 750         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        755                 760                 765             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    770                 775                 780                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
785                 790                 795                 800 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                805                 810                 815     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            820                 825                 830         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        835                 840                 845             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    850                 855                 860                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
865                 870                 875                 880 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                885                 890                 895     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            900                 905                 910         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        915                 920                 925             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    930                 935                 940                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
945                 950                 955                 960 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                965                 970                 975     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            980                 985                 990         


Lys Thr Cys Pro Ala Gly Val Met  Gly Glu Asn Asn Thr  Leu Val Trp 
        995                 1000                 1005             


Lys Tyr  Ala Asp Ala Gly His  Val Cys His Leu Cys  His Pro Asn 
    1010                 1015                 1020             


Cys Thr  Tyr Gly Cys Thr Gly  Pro Gly Leu Glu Gly  Cys Pro Thr 
    1025                 1030                 1035             


Asn Gly  Pro Lys Ile Pro Ser  Ile Ala Thr Gly Met  Val Gly Ala 
    1040                 1045                 1050             


Leu Leu  Leu Leu Leu Val Val  Ala Leu Gly Ile Gly  Leu Phe Met 
    1055                 1060                 1065             


<210> 11
<211> 3207
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccagacg ttgtaatgac ccagacccct ctgtctctcc ccgtaagctt gggcgaccag      120

gcgagcatct cttgtcggtc ttcccagtcc ctggtccatt caaacggcaa tacttacttg      180

cggtggtact tgcagaagcc cggtcaatcc ccaaaagtgc tgatatacaa ggttagcaat      240

cgggtcagtg gagtgcccga ccgcttcagc ggaagcggat ccgggactga cttcactctg      300

aagatcaacc gggtagaagc tgaagacctg ggggtgtact tctgctctca gtcaacacac      360

gtgccatgga cctttggagg tggcaccaag ctggaaatca aatcatcagc ggacgatgcc      420

aaaaaagacg cggccaagaa ggacgatgcc aagaaggatg atgctaaaaa ggatggcgga      480

gtcaaattgg acgagacagg cgggggactg gtgcagcccg gcggtgccat gaaactgtct      540

tgtgtgacca gcggctttac cttcgggcat tattggatga actgggtgcg acagtctcca      600

gagaaagggc tcgagtgggt ggcccagttt cgaaataaac cgtacaatta tgagacctac      660

tattcagatt ctgtgaaagg gcgcttcact atttcacgcg acgacagcaa aagttccgtc      720

taccttcaga tgaacaacct tagagtggag gataccggaa tatactactg cacgggtgcc      780

agttatggca tggagtactt ggggcagggg acatctgtga ccgtttctga gagcaagtac      840

ggaccgccct gccccccttg ccctgccccc gagttcgacg gcggacccag cgtgttcctg      900

ttccccccca agcccaagga caccctgatg atcagccgga cccccgaggt gacctgcgtg      960

gtggtggacg tgagccagga agatcccgag gtccagttca attggtacgt ggacggcgtg     1020

gaagtgcaca acgccaagac caagcccaga gaggaacagt tccagagcac ctaccgggtg     1080

gtgtctgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaagaata caagtgcaag     1140

gtgtccaaca agggcctgcc cagcagcatc gaaaagacca tcagcaaggc caagggccag     1200

cctcgcgagc cccaggtgta caccctgcct ccctcccagg aagagatgac caagaaccag     1260

gtgtccctga cctgcctggt gaagggcttc taccccagcg acatcgccgt ggagtgggag     1320

agcaacggcc agcctgagaa caactacaag accacccctc ccgtgctgga cagcgacggc     1380

agcttcttcc tgtacagccg gctgaccgtg gacaagagcc ggtggcagga aggcaacgtc     1440

tttagctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gagcctgagc     1500

ctgtccctgg gcaagatgtt ctgggtgctg gtggtggtgg gcggggtgct ggcctgctac     1560

agcctgctgg tgacagtggc cttcatcatc ttttgggtga aacggggcag aaagaaactc     1620

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1680

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgcgggt gaagttcagc     1740

agaagcgccg acgcccctgc ctaccagcag ggccagaatc agctgtacaa cgagctgaac     1800

ctgggcagaa gggaagagta cgacgtcctg gataagcgga gaggccggga ccctgagatg     1860

ggcggcaagc ctcggcggaa gaacccccag gaaggcctgt ataacgaact gcagaaagac     1920

aagatggccg aggcctacag cgagatcggc atgaagggcg agcggaggcg gggcaagggc     1980

cacgacggcc tgtatcaggg cctgtccacc gccaccaagg atacctacga cgccctgcac     2040

atgcaggccc tgcccccaag gctcgagggc ggcggagagg gcagaggaag tcttctaaca     2100

tgcggtgacg tggaggagaa tcccggccct aggatgcttc tcctggtgac aagccttctg     2160

ctctgtgagt taccacaccc agcattcctc ctgatcccac gcaaagtgtg taacggaata     2220

ggtattggtg aatttaaaga ctcactctcc ataaatgcta cgaatattaa acacttcaaa     2280

aactgcacct ccatcagtgg cgatctccac atcctgccgg tggcatttag gggtgactcc     2340

ttcacacata ctcctcctct ggatccacag gaactggata ttctgaaaac cgtaaaggaa     2400

atcacagggt ttttgctgat tcaggcttgg cctgaaaaca ggacggacct ccatgccttt     2460

gagaacctag aaatcatacg cggcaggacc aagcaacatg gtcagttttc tcttgcagtc     2520

gtcagcctga acataacatc cttgggatta cgctccctca aggagataag tgatggagat     2580

gtgataattt caggaaacaa aaatttgtgc tatgcaaata caataaactg gaaaaaactg     2640

tttgggacct ccggtcagaa aaccaaaatt ataagcaaca gaggtgaaaa cagctgcaag     2700

gccacaggcc aggtctgcca tgccttgtgc tcccccgagg gctgctgggg cccggagccc     2760

agggactgcg tctcttgccg gaatgtcagc cgaggcaggg aatgcgtgga caagtgcaac     2820

cttctggagg gtgagccaag ggagtttgtg gagaactctg agtgcataca gtgccaccca     2880

gagtgcctgc ctcaggccat gaacatcacc tgcacaggac ggggaccaga caactgtatc     2940

cagtgtgccc actacattga cggcccccac tgcgtcaaga cctgcccggc aggagtcatg     3000

ggagaaaaca acaccctggt ctggaagtac gcagacgccg gccatgtgtg ccacctgtgc     3060

catccaaact gcacctacgg atgcactggg ccaggtcttg aaggctgtcc aacgaatggg     3120

cctaagatcc cgtccatcgc cactgggatg gtgggggccc tcctcttgct gctggtggtg     3180

gccctgggga tcggcctctt catgtga                                         3207


