                         SEQUENCE LISTING

<110>  Stichting Katholieke Universiteit
 
<120>  Minigene for the treatment of Usher syndrome type 2a
       and USH2A-associated retinitis pigmentosa

<130>  P6069216PCT

<150>  EP18159185.0
<151>  2018-02-28

<160>  87    

<170>  PatentIn version 3.5

<210>  1
<211>  5202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  1

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Lys 
        35                  40                  45              


Val Ser Ile Val Pro Thr Gln Ala Val Cys Gly Leu Pro Asp Arg Ser 
    50                  55                  60                  


Thr Phe Cys His Ser Ser Ala Ala Ala Glu Ser Ile Gln Phe Cys Thr 
65                  70                  75                  80  


Gln Arg Phe Cys Ile Gln Asp Cys Pro Tyr Arg Ser Ser His Pro Thr 
                85                  90                  95      


Tyr Thr Ala Leu Phe Ser Ala Gly Leu Ser Ser Cys Ile Thr Pro Asp 
            100                 105                 110         


Lys Asn Asp Leu His Pro Asn Ala His Ser Asn Ser Ala Ser Phe Ile 
        115                 120                 125             


Phe Gly Asn His Lys Ser Cys Phe Ser Ser Pro Pro Ser Pro Lys Leu 
    130                 135                 140                 


Met Ala Ser Phe Thr Leu Ala Val Trp Leu Lys Pro Glu Gln Gln Gly 
145                 150                 155                 160 


Val Met Cys Val Ile Glu Lys Thr Val Asp Gly Gln Ile Val Phe Lys 
                165                 170                 175     


Leu Thr Ile Ser Glu Lys Glu Thr Met Phe Tyr Tyr Arg Thr Val Asn 
            180                 185                 190         


Gly Leu Gln Pro Pro Ile Lys Val Met Thr Leu Gly Arg Ile Leu Val 
        195                 200                 205             


Lys Lys Trp Ile His Leu Ser Val Gln Val His Gln Thr Lys Ile Ser 
    210                 215                 220                 


Phe Phe Ile Asn Gly Val Glu Lys Asp His Thr Pro Phe Asn Ala Arg 
225                 230                 235                 240 


Thr Leu Ser Gly Ser Ile Thr Asp Phe Ala Ser Gly Thr Val Gln Ile 
                245                 250                 255     


Gly Gln Ser Leu Asn Gly Leu Glu Gln Phe Val Gly Arg Met Gln Asp 
            260                 265                 270         


Phe Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg Glu Ile Leu Glu Val 
        275                 280                 285             


Phe Ser Gly Asp Leu Leu Arg Leu His Ala Gln Ser His Cys Arg Cys 
    290                 295                 300                 


Pro Gly Ser His Pro Arg Val His Pro Leu Ala Gln Arg Tyr Cys Ile 
305                 310                 315                 320 


Pro Asn Asp Ala Gly Asp Thr Ala Asp Asn Arg Val Ser Arg Leu Asn 
                325                 330                 335     


Pro Glu Ala His Pro Leu Ser Phe Val Asn Asp Asn Asp Val Gly Thr 
            340                 345                 350         


Ser Trp Val Ser Asn Val Phe Thr Asn Ile Thr Gln Leu Asn Gln Gly 
        355                 360                 365             


Val Thr Ile Ser Val Asp Leu Glu Asn Gly Gln Tyr Gln Val Phe Tyr 
    370                 375                 380                 


Ile Ile Ile Gln Phe Phe Ser Pro Gln Pro Thr Glu Ile Arg Ile Gln 
385                 390                 395                 400 


Arg Lys Lys Glu Asn Ser Leu Asp Trp Glu Asp Trp Gln Tyr Phe Ala 
                405                 410                 415     


Arg Asn Cys Gly Ala Phe Gly Met Lys Asn Asn Gly Asp Leu Glu Lys 
            420                 425                 430         


Pro Asp Ser Val Asn Cys Leu Gln Leu Ser Asn Phe Thr Pro Tyr Ser 
        435                 440                 445             


Arg Gly Asn Val Thr Phe Ser Ile Leu Thr Pro Gly Pro Asn Tyr Arg 
    450                 455                 460                 


Pro Gly Tyr Asn Asn Phe Tyr Asn Thr Pro Ser Leu Gln Glu Phe Val 
465                 470                 475                 480 


Lys Ala Thr Gln Ile Arg Phe His Phe His Gly Gln Tyr Tyr Thr Thr 
                485                 490                 495     


Glu Thr Ala Val Asn Leu Arg His Arg Tyr Tyr Ala Val Asp Glu Ile 
            500                 505                 510         


Thr Ile Ser Gly Arg Cys Gln Cys His Gly His Ala Asp Asn Cys Asp 
        515                 520                 525             


Thr Thr Ser Gln Pro Tyr Arg Cys Leu Cys Ser Gln Glu Ser Phe Thr 
    530                 535                 540                 


Glu Gly Leu His Cys Asp Arg Cys Leu Pro Leu Tyr Asn Asp Lys Pro 
545                 550                 555                 560 


Phe Arg Gln Gly Asp Gln Val Tyr Ala Phe Asn Cys Lys Pro Cys Gln 
                565                 570                 575     


Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val Asp Pro 
            580                 585                 590         


Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp Asp Cys 
        595                 600                 605             


Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp Tyr Phe 
    610                 615                 620                 


Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys Lys Pro 
625                 630                 635                 640 


Cys Asp Cys Asp Thr Val Gly Thr Arg Asn Gly Ser Ile Leu Cys Asp 
                645                 650                 655     


Gln Ile Gly Gly Gln Cys Asn Cys Lys Arg His Val Ser Gly Arg Gln 
            660                 665                 670         


Cys Asn Gln Cys Gln Asn Gly Phe Tyr Asn Leu Gln Glu Leu Asp Pro 
        675                 680                 685             


Asp Gly Cys Ser Pro Cys Asn Cys Asn Thr Ser Gly Thr Val Asp Gly 
    690                 695                 700                 


Asp Ile Thr Cys His Gln Asn Ser Gly Gln Cys Lys Cys Lys Ala Asn 
705                 710                 715                 720 


Val Ile Gly Leu Arg Cys Asp His Cys Asn Phe Gly Phe Lys Phe Leu 
                725                 730                 735     


Arg Ser Phe Asn Asp Val Gly Cys Glu Pro Cys Gln Cys Asn Leu His 
            740                 745                 750         


Gly Ser Val Asn Lys Phe Cys Asn Pro His Ser Gly Gln Cys Glu Cys 
        755                 760                 765             


Lys Lys Glu Ala Lys Gly Leu Gln Cys Asp Thr Cys Arg Glu Asn Phe 
    770                 775                 780                 


Tyr Gly Leu Asp Val Thr Asn Cys Lys Ala Cys Asp Cys Asp Thr Ala 
785                 790                 795                 800 


Gly Ser Leu Pro Gly Thr Val Cys Asn Ala Lys Thr Gly Gln Cys Ile 
                805                 810                 815     


Cys Lys Pro Asn Val Glu Gly Arg Gln Cys Asn Lys Cys Leu Glu Gly 
            820                 825                 830         


Asn Phe Tyr Leu Arg Gln Asn Asn Ser Phe Leu Cys Leu Pro Cys Asn 
        835                 840                 845             


Cys Asp Lys Thr Gly Thr Ile Asn Gly Ser Leu Leu Cys Asn Lys Ser 
    850                 855                 860                 


Thr Gly Gln Cys Pro Cys Lys Leu Gly Val Thr Gly Leu Arg Cys Asn 
865                 870                 875                 880 


Gln Cys Glu Pro His Arg Tyr Asn Leu Thr Ile Asp Asn Phe Gln His 
                885                 890                 895     


Cys Gln Met Cys Glu Cys Asp Ser Leu Gly Thr Leu Pro Gly Thr Ile 
            900                 905                 910         


Cys Asp Pro Ile Ser Gly Gln Cys Leu Cys Val Pro Asn Arg Gln Gly 
        915                 920                 925             


Arg Arg Cys Asn Gln Cys Gln Pro Gly Phe Tyr Ile Ser Pro Gly Asn 
    930                 935                 940                 


Ala Thr Gly Cys Leu Pro Cys Ser Cys His Thr Thr Gly Ala Val Asn 
945                 950                 955                 960 


His Ile Cys Asn Ser Leu Thr Gly Gln Cys Val Cys Gln Asp Ala Ser 
                965                 970                 975     


Ile Ala Gly Gln Arg Cys Asp Gln Cys Lys Asp His Tyr Phe Gly Phe 
            980                 985                 990         


Asp Pro Gln Thr Gly Arg Cys Gln  Pro Cys Asn Cys His  Leu Ser Gly 
        995                 1000                 1005             


Ala Leu  Asn Glu Thr Cys His  Leu Val Thr Gly Gln  Cys Phe Cys 
    1010                 1015                 1020             


Lys Gln  Phe Val Thr Gly Ser  Lys Cys Asp Ala Cys  Val Pro Ser 
    1025                 1030                 1035             


Ala Ser  His Leu Asp Val Asn  Asn Leu Leu Gly Cys  Ser Lys Thr 
    1040                 1045                 1050             


Pro Phe  Gln Gln Pro Pro Pro  Arg Gly Gln Val Gln  Ser Ser Ser 
    1055                 1060                 1065             


Ala Ile  Asn Leu Ser Trp Ser  Pro Pro Asp Ser Pro  Asn Ala His 
    1070                 1075                 1080             


Trp Leu  Thr Tyr Ser Leu Leu  Arg Asp Gly Phe Glu  Ile Tyr Thr 
    1085                 1090                 1095             


Thr Glu  Asp Gln Tyr Pro Tyr  Ser Ile Gln Tyr Phe  Leu Asp Thr 
    1100                 1105                 1110             


Asp Leu  Leu Pro Tyr Thr Lys  Tyr Ser Tyr Tyr Ile  Glu Thr Thr 
    1115                 1120                 1125             


Asn Val  His Gly Ser Thr Arg  Ser Val Ala Val Thr  Tyr Lys Thr 
    1130                 1135                 1140             


Lys Pro  Gly Val Pro Glu Gly  Asn Leu Thr Leu Ser  Tyr Ile Ile 
    1145                 1150                 1155             


Pro Ile  Gly Ser Asp Ser Val  Thr Leu Thr Trp Thr  Thr Leu Ser 
    1160                 1165                 1170             


Asn Gln  Ser Gly Pro Ile Glu  Lys Tyr Ile Leu Ser  Cys Ala Pro 
    1175                 1180                 1185             


Leu Ala  Gly Gly Gln Pro Cys  Val Ser Tyr Glu Gly  His Glu Thr 
    1190                 1195                 1200             


Ser Ala  Thr Ile Trp Asn Leu  Val Pro Phe Ala Lys  Tyr Asp Phe 
    1205                 1210                 1215             


Ser Val  Gln Ala Cys Thr Ser  Gly Gly Cys Leu His  Ser Leu Pro 
    1220                 1225                 1230             


Ile Thr  Val Thr Thr Ala Gln  Ala Pro Pro Gln Arg  Leu Ser Pro 
    1235                 1240                 1245             


Pro Lys  Met Gln Lys Ile Ser  Ser Thr Glu Leu His  Val Glu Trp 
    1250                 1255                 1260             


Ser Pro  Pro Ala Glu Leu Asn  Gly Ile Ile Ile Arg  Tyr Glu Leu 
    1265                 1270                 1275             


Tyr Met  Arg Arg Leu Arg Ser  Thr Lys Glu Thr Thr  Ser Glu Glu 
    1280                 1285                 1290             


Ser Arg  Val Phe Gln Ser Ser  Gly Trp Leu Ser Pro  His Ser Phe 
    1295                 1300                 1305             


Val Glu  Ser Ala Asn Glu Asn  Ala Leu Lys Pro Pro  Gln Thr Met 
    1310                 1315                 1320             


Thr Thr  Ile Thr Gly Leu Glu  Pro Tyr Thr Lys Tyr  Glu Phe Arg 
    1325                 1330                 1335             


Val Leu  Ala Val Asn Met Ala  Gly Ser Val Ser Ser  Ala Trp Val 
    1340                 1345                 1350             


Ser Glu  Arg Thr Gly Glu Ser  Ala Pro Val Phe Met  Ile Pro Pro 
    1355                 1360                 1365             


Ser Val  Phe Pro Leu Ser Ser  Tyr Ser Leu Asn Ile  Ser Trp Glu 
    1370                 1375                 1380             


Lys Pro  Ala Asp Asn Val Thr  Arg Gly Lys Val Val  Gly Tyr Asp 
    1385                 1390                 1395             


Ile Asn  Met Leu Ser Glu Gln  Ser Pro Gln Gln Ser  Ile Pro Met 
    1400                 1405                 1410             


Ala Phe  Ser Gln Leu Leu His  Thr Ala Lys Ser Gln  Glu Leu Ser 
    1415                 1420                 1425             


Tyr Thr  Val Glu Gly Leu Lys  Pro Tyr Arg Ile Tyr  Glu Phe Thr 
    1430                 1435                 1440             


Ile Thr  Leu Cys Asn Ser Val  Gly Cys Val Thr Ser  Ala Ser Gly 
    1445                 1450                 1455             


Ala Gly  Gln Thr Leu Ala Ala  Ala Pro Ala Gln Leu  Arg Pro Pro 
    1460                 1465                 1470             


Leu Val  Lys Gly Ile Asn Ser  Thr Thr Ile His Leu  Arg Trp Phe 
    1475                 1480                 1485             


Pro Pro  Glu Glu Leu Asn Gly  Pro Ser Pro Ile Tyr  Gln Leu Glu 
    1490                 1495                 1500             


Arg Arg  Glu Ser Ser Leu Pro  Ala Leu Met Thr Thr  Met Met Lys 
    1505                 1510                 1515             


Gly Ile  Arg Phe Ile Gly Asn  Gly Tyr Cys Lys Phe  Pro Ser Ser 
    1520                 1525                 1530             


Thr His  Pro Val Asn Thr Asp  Phe Thr Gly Ile Lys  Ala Ser Phe 
    1535                 1540                 1545             


Arg Thr  Lys Val Pro Glu Gly  Leu Ile Val Phe Ala  Ala Ser Pro 
    1550                 1555                 1560             


Gly Asn  Gln Glu Glu Tyr Phe  Ala Leu Gln Leu Lys  Lys Gly Arg 
    1565                 1570                 1575             


Leu Tyr  Phe Leu Phe Asp Pro  Gln Gly Ser Pro Val  Glu Val Thr 
    1580                 1585                 1590             


Thr Thr  Asn Asp His Gly Lys  Gln Tyr Ser Asp Gly  Lys Trp His 
    1595                 1600                 1605             


Glu Ile  Ile Ala Ile Arg His  Gln Ala Phe Gly Gln  Ile Thr Leu 
    1610                 1615                 1620             


Asp Gly  Ile Tyr Thr Gly Ser  Ser Ala Ile Leu Asn  Gly Ser Thr 
    1625                 1630                 1635             


Val Ile  Gly Asp Asn Thr Gly  Val Phe Leu Gly Gly  Leu Pro Arg 
    1640                 1645                 1650             


Ser Tyr  Thr Ile Leu Arg Lys  Asp Pro Glu Ile Ile  Gln Lys Gly 
    1655                 1660                 1665             


Phe Val  Gly Cys Leu Lys Asp  Val His Phe Met Lys  Asn Tyr Asn 
    1670                 1675                 1680             


Pro Ser  Ala Ile Trp Glu Pro  Leu Asp Trp Gln Ser  Ser Glu Glu 
    1685                 1690                 1695             


Gln Ile  Asn Val Tyr Asn Ser  Trp Glu Gly Cys Pro  Ala Ser Leu 
    1700                 1705                 1710             


Asn Glu  Gly Ala Gln Phe Leu  Gly Ala Gly Phe Leu  Glu Leu His 
    1715                 1720                 1725             


Pro Tyr  Met Phe His Gly Gly  Met Asn Phe Glu Ile  Ser Phe Lys 
    1730                 1735                 1740             


Phe Arg  Thr Asp Gln Leu Asn  Gly Leu Leu Leu Phe  Val Tyr Asn 
    1745                 1750                 1755             


Lys Asp  Gly Pro Asp Phe Leu  Ala Met Glu Leu Lys  Ser Gly Ile 
    1760                 1765                 1770             


Leu Thr  Phe Arg Leu Asn Thr  Ser Leu Ala Phe Thr  Gln Val Asp 
    1775                 1780                 1785             


Leu Leu  Leu Gly Leu Ser Tyr  Cys Asn Gly Lys Trp  Asn Lys Val 
    1790                 1795                 1800             


Ile Ile  Lys Lys Glu Gly Ser  Phe Ile Ser Ala Ser  Val Asn Gly 
    1805                 1810                 1815             


Leu Met  Lys His Ala Ser Glu  Ser Gly Asp Gln Pro  Leu Val Val 
    1820                 1825                 1830             


Asn Ser  Pro Val Tyr Val Gly  Gly Ile Pro Gln Glu  Leu Leu Asn 
    1835                 1840                 1845             


Ser Tyr  Gln His Leu Cys Leu  Glu Gln Gly Phe Gly  Gly Cys Met 
    1850                 1855                 1860             


Lys Asp  Val Lys Phe Thr Arg  Gly Ala Val Val Asn  Leu Ala Ser 
    1865                 1870                 1875             


Val Ser  Ser Gly Ala Val Arg  Val Asn Leu Asp Gly  Cys Leu Ser 
    1880                 1885                 1890             


Thr Asp  Ser Ala Val Asn Cys  Arg Gly Asn Asp Ser  Ile Leu Val 
    1895                 1900                 1905             


Tyr Gln  Gly Lys Glu Gln Ser  Val Tyr Glu Gly Gly  Leu Gln Pro 
    1910                 1915                 1920             


Phe Thr  Glu Tyr Leu Tyr Arg  Val Ile Ala Ser His  Glu Gly Gly 
    1925                 1930                 1935             


Ser Val  Tyr Ser Asp Trp Ser  Arg Gly Arg Thr Thr  Gly Ala Ala 
    1940                 1945                 1950             


Pro Gln  Ser Val Pro Thr Pro  Ser Arg Val Arg Ser  Leu Asn Gly 
    1955                 1960                 1965             


Tyr Ser  Ile Glu Val Thr Trp  Asp Glu Pro Val Val  Arg Gly Val 
    1970                 1975                 1980             


Ile Glu  Lys Tyr Ile Leu Lys  Ala Tyr Ser Glu Asp  Ser Thr Arg 
    1985                 1990                 1995             


Pro Pro  Arg Met Pro Ser Ala  Ser Ala Glu Phe Val  Asn Thr Ser 
    2000                 2005                 2010             


Asn Leu  Thr Gly Ile Leu Thr  Gly Leu Leu Pro Phe  Lys Asn Tyr 
    2015                 2020                 2025             


Ala Val  Thr Leu Thr Ala Cys  Thr Leu Ala Gly Cys  Thr Glu Ser 
    2030                 2035                 2040             


Ser His  Ala Leu Asn Ile Ser  Thr Pro Gln Glu Ala  Pro Gln Glu 
    2045                 2050                 2055             


Val Gln  Pro Pro Val Ala Lys  Ser Leu Pro Ser Ser  Leu Leu Leu 
    2060                 2065                 2070             


Ser Trp  Asn Pro Pro Lys Lys  Ala Asn Gly Ile Ile  Thr Gln Tyr 
    2075                 2080                 2085             


Cys Leu  Tyr Met Asp Gly Arg  Leu Ile Tyr Ser Gly  Ser Glu Glu 
    2090                 2095                 2100             


Asn Tyr  Ile Val Thr Asp Leu  Ala Val Phe Thr Pro  His Gln Phe 
    2105                 2110                 2115             


Leu Leu  Ser Ala Cys Thr His  Val Gly Cys Thr Asn  Ser Ser Trp 
    2120                 2125                 2130             


Val Leu  Leu Tyr Thr Ala Gln  Leu Pro Pro Glu His  Val Asp Ser 
    2135                 2140                 2145             


Pro Val  Leu Thr Val Leu Asp  Ser Arg Thr Ile His  Ile Gln Trp 
    2150                 2155                 2160             


Lys Gln  Pro Arg Lys Ile Ser  Gly Ile Leu Glu Arg  Tyr Val Leu 
    2165                 2170                 2175             


Tyr Met  Ser Asn His Thr His  Asp Phe Thr Ile Trp  Ser Val Ile 
    2180                 2185                 2190             


Tyr Asn  Ser Thr Glu Leu Phe  Gln Asp His Met Leu  Gln Tyr Val 
    2195                 2200                 2205             


Leu Pro  Gly Asn Lys Tyr Leu  Ile Lys Leu Gly Ala  Cys Thr Gly 
    2210                 2215                 2220             


Gly Gly  Cys Thr Val Ser Glu  Ala Ser Glu Ala Leu  Thr Asp Glu 
    2225                 2230                 2235             


Asp Ile  Pro Glu Gly Val Pro  Ala Pro Lys Ala His  Ser Tyr Ser 
    2240                 2245                 2250             


Pro Asp  Ser Phe Asn Val Ser  Trp Thr Glu Pro Glu  Tyr Pro Asn 
    2255                 2260                 2265             


Gly Val  Ile Thr Ser Tyr Gly  Leu Tyr Leu Asp Gly  Ile Leu Ile 
    2270                 2275                 2280             


His Asn  Ser Ser Glu Leu Ser  Tyr Arg Ala Tyr Gly  Phe Ala Pro 
    2285                 2290                 2295             


Trp Ser  Leu His Ser Phe Arg  Val Gln Ala Cys Thr  Ala Lys Gly 
    2300                 2305                 2310             


Cys Ala  Leu Gly Pro Leu Val  Glu Asn Arg Thr Leu  Glu Ala Pro 
    2315                 2320                 2325             


Pro Glu  Gly Thr Val Asn Val  Phe Val Lys Thr Gln  Gly Ser Arg 
    2330                 2335                 2340             


Lys Ala  His Val Arg Trp Glu  Ala Pro Phe Arg Pro  Asn Gly Leu 
    2345                 2350                 2355             


Leu Thr  His Ser Val Leu Phe  Thr Gly Ile Phe Tyr  Val Asp Pro 
    2360                 2365                 2370             


Val Gly  Asn Asn Tyr Thr Leu  Leu Asn Val Thr Lys  Val Met Tyr 
    2375                 2380                 2385             


Ser Gly  Glu Glu Thr Asn Leu  Trp Val Leu Ile Asp  Gly Leu Val 
    2390                 2395                 2400             


Pro Phe  Thr Asn Tyr Thr Val  Gln Val Asn Ile Ser  Asn Ser Gln 
    2405                 2410                 2415             


Gly Ser  Leu Ile Thr Asp Pro  Ile Thr Ile Ala Met  Pro Pro Gly 
    2420                 2425                 2430             


Ala Pro  Asp Gly Val Leu Pro  Pro Arg Leu Ser Ser  Ala Thr Pro 
    2435                 2440                 2445             


Thr Ser  Leu Gln Val Val Trp  Ser Thr Pro Ala Arg  Asn Asn Ala 
    2450                 2455                 2460             


Pro Gly  Ser Pro Arg Tyr Gln  Leu Gln Met Arg Ser  Gly Asp Ser 
    2465                 2470                 2475             


Thr His  Gly Phe Leu Glu Leu  Phe Ser Asn Pro Ser  Ala Ser Leu 
    2480                 2485                 2490             


Ser Tyr  Glu Val Ser Asp Leu  Gln Pro Tyr Thr Glu  Tyr Met Phe 
    2495                 2500                 2505             


Arg Leu  Val Ala Ser Asn Gly  Phe Gly Ser Ala His  Ser Ser Trp 
    2510                 2515                 2520             


Ile Pro  Phe Met Thr Ala Glu  Asp Lys Pro Gly Pro  Val Val Pro 
    2525                 2530                 2535             


Pro Ile  Leu Leu Asp Val Lys  Ser Arg Met Met Leu  Val Thr Trp 
    2540                 2545                 2550             


Gln His  Pro Arg Lys Ser Asn  Gly Val Ile Thr His  Tyr Asn Ile 
    2555                 2560                 2565             


Tyr Leu  His Gly Arg Leu Tyr  Leu Arg Thr Pro Gly  Asn Val Thr 
    2570                 2575                 2580             


Asn Cys  Thr Val Met His Leu  His Pro Tyr Thr Ala  Tyr Lys Phe 
    2585                 2590                 2595             


Gln Val  Glu Ala Cys Thr Ser  Lys Gly Cys Ser Leu  Ser Pro Glu 
    2600                 2605                 2610             


Ser Gln  Thr Val Trp Thr Leu  Pro Gly Ala Pro Glu  Gly Ile Pro 
    2615                 2620                 2625             


Ser Pro  Glu Leu Phe Ser Asp  Thr Pro Thr Ser Val  Ile Ile Ser 
    2630                 2635                 2640             


Trp Gln  Pro Pro Thr His Pro  Asn Gly Leu Val Glu  Asn Phe Thr 
    2645                 2650                 2655             


Ile Glu  Arg Arg Val Lys Gly  Lys Glu Glu Val Thr  Thr Leu Val 
    2660                 2665                 2670             


Thr Leu  Pro Arg Ser His Ser  Met Arg Phe Ile Asp  Lys Thr Ser 
    2675                 2680                 2685             


Ala Leu  Ser Pro Trp Thr Lys  Tyr Glu Tyr Arg Val  Leu Met Ser 
    2690                 2695                 2700             


Thr Leu  His Gly Gly Thr Asn  Ser Ser Ala Trp Val  Glu Val Thr 
    2705                 2710                 2715             


Thr Arg  Pro Ser Arg Pro Ala  Gly Val Gln Pro Pro  Val Val Thr 
    2720                 2725                 2730             


Val Leu  Glu Pro Asp Ala Val  Gln Val Thr Trp Lys  Pro Pro Leu 
    2735                 2740                 2745             


Ile Gln  Asn Gly Asp Ile Leu  Ser Tyr Glu Ile His  Met Pro Asp 
    2750                 2755                 2760             


Pro His  Ile Thr Leu Thr Asn  Val Thr Ser Ala Val  Leu Ser Gln 
    2765                 2770                 2775             


Lys Val  Thr His Leu Ile Pro  Phe Thr Asn Tyr Ser  Val Thr Ile 
    2780                 2785                 2790             


Val Ala  Cys Ser Gly Gly Asn  Gly Tyr Leu Gly Gly  Cys Thr Glu 
    2795                 2800                 2805             


Ser Leu  Pro Thr Tyr Val Thr  Thr His Pro Thr Val  Pro Gln Asn 
    2810                 2815                 2820             


Val Gly  Pro Leu Ser Val Ile  Pro Leu Ser Glu Ser  Tyr Val Val 
    2825                 2830                 2835             


Ile Ser  Trp Gln Pro Pro Ser  Lys Pro Asn Gly Pro  Asn Leu Arg 
    2840                 2845                 2850             


Tyr Glu  Leu Leu Arg Arg Lys  Ile Gln Gln Pro Leu  Ala Ser Asn 
    2855                 2860                 2865             


Pro Pro  Glu Asp Leu Asn Arg  Trp His Asn Ile Tyr  Ser Gly Thr 
    2870                 2875                 2880             


Gln Trp  Leu Tyr Glu Asp Lys  Gly Leu Ser Arg Phe  Thr Thr Tyr 
    2885                 2890                 2895             


Glu Tyr  Met Leu Phe Val His  Asn Ser Val Gly Phe  Thr Pro Ser 
    2900                 2905                 2910             


Arg Glu  Val Thr Val Thr Thr  Leu Ala Gly Leu Pro  Glu Arg Gly 
    2915                 2920                 2925             


Ala Asn  Leu Thr Ala Ser Val  Leu Asn His Thr Ala  Ile Asp Val 
    2930                 2935                 2940             


Arg Trp  Ala Lys Pro Thr Val  Gln Asp Leu Gln Gly  Glu Val Glu 
    2945                 2950                 2955             


Tyr Tyr  Thr Leu Phe Trp Ser  Ser Ala Thr Ser Asn  Asp Ser Leu 
    2960                 2965                 2970             


Lys Ile  Leu Pro Asp Val Asn  Ser His Val Ile Gly  His Leu Lys 
    2975                 2980                 2985             


Pro Asn  Thr Glu Tyr Trp Ile  Phe Ile Ser Val Phe  Asn Gly Val 
    2990                 2995                 3000             


His Ser  Ile Asn Ser Ala Gly  Leu His Ala Thr Thr  Cys Asp Gly 
    3005                 3010                 3015             


Glu Pro  Gln Gly Met Leu Pro  Pro Glu Val Val Ile  Ile Asn Ser 
    3020                 3025                 3030             


Thr Ala  Val Arg Val Ile Trp  Thr Ser Pro Ser Asn  Pro Asn Gly 
    3035                 3040                 3045             


Val Val  Thr Glu Tyr Ser Ile  Tyr Val Asn Asn Lys  Leu Tyr Lys 
    3050                 3055                 3060             


Thr Gly  Met Asn Val Pro Gly  Ser Phe Ile Leu Arg  Asp Leu Ser 
    3065                 3070                 3075             


Pro Phe  Thr Ile Tyr Asp Ile  Gln Val Glu Val Cys  Thr Ile Tyr 
    3080                 3085                 3090             


Ala Cys  Val Lys Ser Asn Gly  Thr Gln Ile Thr Thr  Val Glu Asp 
    3095                 3100                 3105             


Thr Pro  Ser Asp Ile Pro Thr  Pro Thr Ile Arg Gly  Ile Thr Ser 
    3110                 3115                 3120             


Arg Ser  Leu Gln Ile Asp Trp  Val Ser Pro Arg Lys  Pro Asn Gly 
    3125                 3130                 3135             


Ile Ile  Leu Gly Tyr Asp Leu  Leu Trp Lys Thr Trp  Tyr Pro Cys 
    3140                 3145                 3150             


Ala Lys  Thr Gln Lys Leu Val  Gln Asp Gln Ser Asp  Glu Leu Cys 
    3155                 3160                 3165             


Lys Ala  Val Arg Cys Gln Lys  Pro Glu Ser Ile Cys  Gly His Ile 
    3170                 3175                 3180             


Cys Tyr  Ser Ser Glu Ala Lys  Val Cys Cys Asn Gly  Val Leu Tyr 
    3185                 3190                 3195             


Asn Pro  Lys Pro Gly His Arg  Cys Cys Glu Glu Lys  Tyr Ile Pro 
    3200                 3205                 3210             


Phe Val  Leu Asn Ser Thr Gly  Val Cys Cys Gly Gly  Arg Ile Gln 
    3215                 3220                 3225             


Glu Ala  Gln Pro Asn His Gln  Cys Cys Ser Gly Tyr  Tyr Ala Arg 
    3230                 3235                 3240             


Ile Leu  Pro Gly Glu Val Cys  Cys Pro Asp Glu Gln  His Asn Arg 
    3245                 3250                 3255             


Val Ser  Val Gly Ile Gly Asp  Ser Cys Cys Gly Arg  Met Pro Tyr 
    3260                 3265                 3270             


Ser Thr  Ser Gly Asn Gln Ile  Cys Cys Ala Gly Arg  Leu His Asp 
    3275                 3280                 3285             


Gly His  Gly Gln Lys Cys Cys  Gly Arg Gln Ile Val  Ser Asn Asp 
    3290                 3295                 3300             


Leu Glu  Cys Cys Gly Gly Glu  Glu Gly Val Val Tyr  Asn Arg Leu 
    3305                 3310                 3315             


Pro Gly  Met Phe Cys Cys Gly  Gln Asp Tyr Val Asn  Met Ser Asp 
    3320                 3325                 3330             


Thr Ile  Cys Cys Ser Ala Ser  Ser Gly Glu Ser Lys  Ala His Ile 
    3335                 3340                 3345             


Lys Lys  Asn Asp Pro Val Pro  Val Lys Cys Cys Glu  Thr Glu Leu 
    3350                 3355                 3360             


Ile Pro  Lys Ser Gln Lys Cys  Cys Asn Gly Val Gly  Tyr Asn Pro 
    3365                 3370                 3375             


Leu Lys  Tyr Val Cys Ser Asp  Lys Ile Ser Thr Gly  Met Met Met 
    3380                 3385                 3390             


Lys Glu  Thr Lys Glu Cys Arg  Ile Leu Cys Pro Ala  Ser Met Glu 
    3395                 3400                 3405             


Ala Thr  Glu His Cys Gly Arg  Cys Asp Phe Asn Phe  Thr Ser His 
    3410                 3415                 3420             


Ile Cys  Thr Val Ile Arg Gly  Ser His Asn Ser Thr  Gly Lys Ala 
    3425                 3430                 3435             


Ser Ile  Glu Glu Met Cys Ser  Ser Ala Glu Glu Thr  Ile His Thr 
    3440                 3445                 3450             


Gly Ser  Val Asn Thr Tyr Ser  Tyr Thr Asp Val Asn  Leu Lys Pro 
    3455                 3460                 3465             


Tyr Met  Thr Tyr Glu Tyr Arg  Ile Ser Ala Trp Asn  Ser Tyr Gly 
    3470                 3475                 3480             


Arg Gly  Leu Ser Lys Ala Val  Arg Ala Arg Thr Lys  Glu Asp Val 
    3485                 3490                 3495             


Pro Gln  Gly Val Ser Pro Pro  Thr Trp Thr Lys Ile  Asp Asn Leu 
    3500                 3505                 3510             


Glu Asp  Thr Ile Val Leu Asn  Trp Arg Lys Pro Ile  Gln Ser Asn 
    3515                 3520                 3525             


Gly Pro  Ile Ile Tyr Tyr Ile  Leu Leu Arg Asn Gly  Ile Glu Arg 
    3530                 3535                 3540             


Phe Arg  Gly Thr Ser Leu Ser  Phe Ser Asp Lys Glu  Gly Ile Gln 
    3545                 3550                 3555             


Pro Phe  Gln Glu Tyr Ser Tyr  Gln Leu Lys Ala Cys  Thr Val Ala 
    3560                 3565                 3570             


Gly Cys  Ala Thr Ser Ser Lys  Val Val Ala Ala Thr  Thr Gln Gly 
    3575                 3580                 3585             


Val Pro  Glu Ser Ile Leu Pro  Pro Ser Ile Thr Ala  Leu Ser Ala 
    3590                 3595                 3600             


Val Ala  Leu His Leu Ser Trp  Ser Val Pro Glu Lys  Ser Asn Gly 
    3605                 3610                 3615             


Val Ile  Lys Glu Tyr Gln Ile  Arg Gln Val Gly Lys  Gly Leu Ile 
    3620                 3625                 3630             


His Thr  Asp Thr Thr Asp Arg  Arg Gln His Thr Val  Thr Gly Leu 
    3635                 3640                 3645             


Gln Pro  Tyr Thr Asn Tyr Ser  Phe Thr Leu Thr Ala  Cys Thr Ser 
    3650                 3655                 3660             


Ala Gly  Cys Thr Ser Ser Glu  Pro Phe Leu Gly Gln  Thr Leu Gln 
    3665                 3670                 3675             


Ala Ala  Pro Glu Gly Val Trp  Val Thr Pro Arg His  Ile Ile Ile 
    3680                 3685                 3690             


Asn Ser  Thr Thr Val Glu Leu  Tyr Trp Ser Leu Pro  Glu Lys Pro 
    3695                 3700                 3705             


Asn Gly  Leu Val Ser Gln Tyr  Gln Leu Ser Arg Asn  Gly Asn Leu 
    3710                 3715                 3720             


Leu Phe  Leu Gly Gly Ser Glu  Glu Gln Asn Phe Thr  Asp Lys Asn 
    3725                 3730                 3735             


Leu Glu  Pro Asn Ser Arg Tyr  Thr Tyr Lys Leu Glu  Val Lys Thr 
    3740                 3745                 3750             


Gly Gly  Gly Ser Ser Ala Ser  Asp Asp Tyr Ile Val  Gln Thr Pro 
    3755                 3760                 3765             


Met Ser  Thr Pro Glu Glu Ile  Tyr Pro Pro Tyr Asn  Ile Thr Val 
    3770                 3775                 3780             


Ile Gly  Pro Tyr Ser Ile Phe  Val Ala Trp Ile Pro  Pro Gly Ile 
    3785                 3790                 3795             


Leu Ile  Pro Glu Ile Pro Val  Glu Tyr Asn Val Leu  Leu Asn Asp 
    3800                 3805                 3810             


Gly Ser  Val Thr Pro Leu Ala  Phe Ser Val Gly His  His Gln Ser 
    3815                 3820                 3825             


Thr Leu  Leu Glu Asn Leu Thr  Pro Phe Thr Gln Tyr  Glu Ile Arg 
    3830                 3835                 3840             


Ile Gln  Ala Cys Gln Asn Gly  Ser Cys Gly Val Ser  Ser Arg Met 
    3845                 3850                 3855             


Phe Val  Lys Thr Pro Glu Ala  Ala Pro Met Asp Leu  Asn Ser Pro 
    3860                 3865                 3870             


Val Leu  Lys Ala Leu Gly Ser  Ala Cys Ile Glu Ile  Lys Trp Met 
    3875                 3880                 3885             


Pro Pro  Glu Lys Pro Asn Gly  Ile Ile Ile Asn Tyr  Phe Ile Tyr 
    3890                 3895                 3900             


Arg Arg  Pro Ala Gly Ile Glu  Glu Glu Ser Val Leu  Phe Val Trp 
    3905                 3910                 3915             


Ser Glu  Gly Ala Leu Glu Phe  Met Asp Glu Gly Asp  Thr Leu Arg 
    3920                 3925                 3930             


Pro Phe  Thr Leu Tyr Glu Tyr  Arg Val Arg Ala Cys  Asn Ser Lys 
    3935                 3940                 3945             


Gly Ser  Val Glu Ser Leu Trp  Ser Leu Thr Gln Thr  Leu Glu Ala 
    3950                 3955                 3960             


Pro Pro  Gln Asp Phe Pro Ala  Pro Trp Ala Gln Ala  Thr Ser Ala 
    3965                 3970                 3975             


His Ser  Val Leu Leu Asn Trp  Thr Lys Pro Glu Ser  Pro Asn Gly 
    3980                 3985                 3990             


Ile Ile  Ser His Tyr Arg Val  Val Tyr Gln Glu Arg  Pro Asp Asp 
    3995                 4000                 4005             


Pro Thr  Phe Asn Ser Pro Thr  Val His Ala Phe Thr  Val Lys Gly 
    4010                 4015                 4020             


Thr Ser  His Gln Ala His Leu  Tyr Gly Leu Glu Pro  Phe Thr Thr 
    4025                 4030                 4035             


Tyr Arg  Ile Gly Val Val Ala  Ala Asn His Ala Gly  Glu Ile Leu 
    4040                 4045                 4050             


Ser Pro  Trp Thr Leu Ile Gln  Thr Leu Glu Ser Ser  Pro Ser Gly 
    4055                 4060                 4065             


Leu Arg  Asn Phe Ile Val Glu  Gln Lys Glu Asn Gly  Arg Ala Leu 
    4070                 4075                 4080             


Leu Leu  Gln Trp Ser Glu Pro  Met Arg Thr Asn Gly  Val Ile Lys 
    4085                 4090                 4095             


Thr Tyr  Asn Ile Phe Ser Asp  Gly Phe Leu Glu Tyr  Ser Gly Leu 
    4100                 4105                 4110             


Asn Arg  Gln Phe Leu Phe Arg  Arg Leu Asp Pro Phe  Thr Leu Tyr 
    4115                 4120                 4125             


Thr Leu  Thr Leu Glu Ala Cys  Thr Arg Ala Gly Cys  Ala His Ser 
    4130                 4135                 4140             


Ala Pro  Gln Pro Leu Trp Thr  Asp Glu Ala Pro Pro  Asp Ser Gln 
    4145                 4150                 4155             


Leu Ala  Pro Thr Val His Ser  Val Lys Ser Thr Ser  Val Glu Leu 
    4160                 4165                 4170             


Ser Trp  Ser Glu Pro Val Asn  Pro Asn Gly Lys Ile  Ile Arg Tyr 
    4175                 4180                 4185             


Glu Val  Ile Arg Arg Cys Phe  Glu Gly Lys Ala Trp  Gly Asn Gln 
    4190                 4195                 4200             


Thr Ile  Gln Ala Asp Glu Lys  Ile Val Phe Thr Glu  Tyr Asn Thr 
    4205                 4210                 4215             


Glu Arg  Asn Thr Phe Met Tyr  Asn Asp Thr Gly Leu  Gln Pro Trp 
    4220                 4225                 4230             


Thr Gln  Cys Glu Tyr Lys Ile  Tyr Thr Trp Asn Ser  Ala Gly His 
    4235                 4240                 4245             


Thr Cys  Ser Ser Trp Asn Val  Val Arg Thr Leu Gln  Ala Pro Pro 
    4250                 4255                 4260             


Glu Gly  Leu Ser Pro Pro Val  Ile Ser Tyr Val Ser  Met Asn Pro 
    4265                 4270                 4275             


Gln Lys  Leu Leu Ile Ser Trp  Ile Pro Pro Glu Gln  Ser Asn Gly 
    4280                 4285                 4290             


Ile Ile  Gln Ser Tyr Arg Leu  Gln Arg Asn Glu Met  Leu Tyr Pro 
    4295                 4300                 4305             


Phe Ser  Phe Asp Pro Val Thr  Phe Asn Tyr Thr Asp  Glu Glu Leu 
    4310                 4315                 4320             


Leu Pro  Phe Ser Thr Tyr Ser  Tyr Ala Leu Gln Ala  Cys Thr Ser 
    4325                 4330                 4335             


Gly Gly  Cys Ser Thr Ser Lys  Pro Thr Ser Ile Thr  Thr Leu Glu 
    4340                 4345                 4350             


Ala Ala  Pro Ser Glu Val Ser  Pro Pro Asp Leu Trp  Ala Val Ser 
    4355                 4360                 4365             


Ala Thr  Gln Met Asn Val Cys  Trp Ser Pro Pro Thr  Val Gln Asn 
    4370                 4375                 4380             


Gly Lys  Ile Thr Lys Tyr Leu  Val Arg Tyr Asp Asn  Lys Glu Ser 
    4385                 4390                 4395             


Leu Ala  Gly Gln Gly Leu Cys  Leu Leu Val Ser His  Leu Gln Pro 
    4400                 4405                 4410             


Tyr Ser  Gln Tyr Asn Phe Ser  Leu Val Ala Cys Thr  Asn Gly Gly 
    4415                 4420                 4425             


Cys Thr  Ala Ser Val Ser Lys  Ser Ala Trp Thr Met  Glu Ala Leu 
    4430                 4435                 4440             


Pro Glu  Asn Met Asp Ser Pro  Thr Leu Gln Val Thr  Gly Ser Glu 
    4445                 4450                 4455             


Ser Ile  Glu Ile Thr Trp Lys  Pro Pro Arg Asn Pro  Asn Gly Gln 
    4460                 4465                 4470             


Ile Arg  Ser Tyr Glu Leu Arg  Arg Asp Gly Thr Ile  Val Tyr Thr 
    4475                 4480                 4485             


Gly Leu  Glu Thr Arg Tyr Arg  Asp Phe Thr Leu Thr  Pro Gly Val 
    4490                 4495                 4500             


Glu Tyr  Ser Tyr Thr Val Thr  Ala Ser Asn Ser Gln  Gly Gly Ile 
    4505                 4510                 4515             


Leu Ser  Pro Leu Val Lys Asp  Arg Thr Ser Pro Ser  Ala Pro Ser 
    4520                 4525                 4530             


Gly Met  Glu Pro Pro Lys Leu  Gln Ala Arg Gly Pro  Gln Glu Ile 
    4535                 4540                 4545             


Leu Val  Asn Trp Asp Pro Pro  Val Arg Thr Asn Gly  Asp Ile Ile 
    4550                 4555                 4560             


Asn Tyr  Thr Leu Phe Ile Arg  Glu Leu Phe Glu Arg  Glu Thr Lys 
    4565                 4570                 4575             


Ile Ile  His Ile Asn Thr Thr  His Asn Ser Phe Gly  Met Gln Ser 
    4580                 4585                 4590             


Tyr Ile  Val Asn Gln Leu Lys  Pro Phe His Arg Tyr  Glu Ile Arg 
    4595                 4600                 4605             


Ile Gln  Ala Cys Thr Thr Leu  Gly Cys Ala Ser Ser  Asp Trp Thr 
    4610                 4615                 4620             


Phe Ile  Gln Thr Pro Glu Ile  Ala Pro Leu Met Gln  Pro Pro Pro 
    4625                 4630                 4635             


His Leu  Glu Val Gln Met Ala  Pro Gly Gly Phe Gln  Pro Thr Val 
    4640                 4645                 4650             


Ser Leu  Leu Trp Thr Gly Pro  Leu Gln Pro Asn Gly  Lys Val Leu 
    4655                 4660                 4665             


Tyr Tyr  Glu Leu Tyr Arg Arg  Gln Ile Ala Thr Gln  Pro Arg Lys 
    4670                 4675                 4680             


Ser Asn  Pro Val Leu Ile Tyr  Asn Gly Ser Ser Thr  Ser Phe Ile 
    4685                 4690                 4695             


Asp Ser  Glu Leu Leu Pro Phe  Thr Glu Tyr Glu Tyr  Gln Val Trp 
    4700                 4705                 4710             


Ala Val  Asn Ser Ala Gly Lys  Ala Pro Ser Ser Trp  Thr Trp Cys 
    4715                 4720                 4725             


Arg Thr  Gly Pro Ala Pro Pro  Glu Gly Leu Arg Ala  Pro Thr Phe 
    4730                 4735                 4740             


His Val  Ile Ser Ser Thr Gln  Ala Val Val Asn Ile  Ser Ala Pro 
    4745                 4750                 4755             


Gly Lys  Pro Asn Gly Ile Val  Ser Leu Tyr Arg Leu  Phe Ser Ser 
    4760                 4765                 4770             


Ser Ala  His Gly Ala Glu Thr  Val Leu Ser Glu Gly  Met Ala Thr 
    4775                 4780                 4785             


Gln Gln  Thr Leu His Gly Leu  Gln Ala Phe Thr Asn  Tyr Ser Ile 
    4790                 4795                 4800             


Gly Val  Glu Ala Cys Thr Cys  Phe Asn Cys Cys Ser  Lys Gly Pro 
    4805                 4810                 4815             


Thr Ala  Glu Leu Arg Thr His  Pro Ala Pro Pro Ser  Gly Leu Ser 
    4820                 4825                 4830             


Ser Pro  Gln Ile Gly Thr Leu  Ala Ser Arg Thr Ala  Ser Phe Arg 
    4835                 4840                 4845             


Trp Ser  Pro Pro Met Phe Pro  Asn Gly Val Ile His  Ser Tyr Glu 
    4850                 4855                 4860             


Leu Gln  Phe His Val Ala Cys  Pro Pro Asp Ser Ala  Leu Pro Cys 
    4865                 4870                 4875             


Thr Pro  Ser Gln Ile Glu Thr  Lys Tyr Thr Gly Leu  Gly Gln Lys 
    4880                 4885                 4890             


Ala Ser  Leu Gly Gly Leu Gln  Pro Tyr Thr Thr Tyr  Lys Leu Arg 
    4895                 4900                 4905             


Val Val  Ala His Asn Glu Val  Gly Ser Thr Ala Ser  Glu Trp Ile 
    4910                 4915                 4920             


Ser Phe  Thr Thr Gln Lys Glu  Leu Pro Gln Tyr Arg  Ala Pro Phe 
    4925                 4930                 4935             


Ser Val  Asp Ser Asn Leu Ser  Val Val Cys Val Asn  Trp Ser Asp 
    4940                 4945                 4950             


Thr Phe  Leu Leu Asn Gly Gln  Leu Lys Glu Tyr Val  Leu Thr Asp 
    4955                 4960                 4965             


Gly Gly  Arg Arg Val Tyr Ser  Gly Leu Asp Thr Thr  Leu Tyr Ile 
    4970                 4975                 4980             


Pro Arg  Thr Ala Asp Lys Thr  Phe Phe Phe Gln Val  Ile Cys Thr 
    4985                 4990                 4995             


Thr Asp  Glu Gly Ser Val Lys  Thr Pro Leu Ile Gln  Tyr Asp Thr 
    5000                 5005                 5010             


Ser Thr  Gly Leu Gly Leu Val  Leu Thr Thr Pro Gly  Lys Lys Lys 
    5015                 5020                 5025             


Gly Ser  Arg Ser Lys Ser Thr  Glu Phe Tyr Ser Glu  Leu Trp Phe 
    5030                 5035                 5040             


Ile Val  Leu Met Ala Met Leu  Gly Leu Ile Leu Leu  Ala Ile Phe 
    5045                 5050                 5055             


Leu Ser  Leu Ile Leu Gln Arg  Lys Ile His Lys Glu  Pro Tyr Ile 
    5060                 5065                 5070             


Arg Glu  Arg Pro Pro Leu Val  Pro Leu Gln Lys Arg  Met Ser Pro 
    5075                 5080                 5085             


Leu Asn  Val Tyr Pro Pro Gly  Glu Asn His Met Gly  Leu Ala Asp 
    5090                 5095                 5100             


Thr Lys  Ile Pro Arg Ser Gly  Thr Pro Val Ser Ile  Arg Ser Asn 
    5105                 5110                 5115             


Arg Ser  Ala Cys Val Leu Arg  Ile Pro Ser Gln Asn  Gln Thr Ser 
    5120                 5125                 5130             


Leu Thr  Tyr Ser Gln Gly Ser  Leu His Arg Ser Val  Ser Gln Leu 
    5135                 5140                 5145             


Met Asp  Ile Gln Asp Lys Lys  Val Leu Met Asp Asn  Ser Leu Trp 
    5150                 5155                 5160             


Glu Ala  Ile Met Gly His Asn  Ser Gly Leu Tyr Val  Asp Glu Glu 
    5165                 5170                 5175             


Asp Leu  Met Asn Ala Ile Lys  Asp Phe Ser Ser Val  Thr Lys Glu 
    5180                 5185                 5190             


Arg Thr  Thr Phe Thr Asp Thr  His Leu 
    5195                 5200         


<210>  2
<211>  15606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  2
atgaattgcc cagttctttc attgggctct ggcttcttgt ttcaggtcat tgaaatgttg       60

atctttgcct attttgcttc aatatccttg actgagtcac gaggtctttt cccaaggctg      120

gagaacgtgg gagctttcaa gaaagtttcc atcgtgccaa cccaagcagt atgtggactc      180

ccagaccgaa gcactttttg tcacagctct gctgctgctg aaagtattca gttctgtacc      240

cagcggtttt gtattcagga ttgcccatac agatcttcac accctaccta cactgccctt      300

ttctcagcag gcctcagtag ctgcatcaca ccagacaaga atgatctgca tcctaacgcc      360

catagcaatt ctgcaagttt tatttttgga aatcacaaga gctgcttttc ttctcctcct      420

tctccaaagc tgatggcatc atttacctta gctgtatggc tgaaacctga gcaacaaggt      480

gtaatgtgtg ttatagaaaa gacagtagat gggcagattg tgttcaaact tacaatatct      540

gagaaagaga ccatgtttta ttatcgcaca gtaaatggtt tgcaacctcc aataaaagta      600

atgacactgg ggagaattct tgtgaagaaa tggattcatc ttagtgtgca ggtgcatcag      660

acaaaaatca gcttctttat caatggcgtg gagaaggatc atacaccttt caatgcaaga      720

actctaagtg gttcaattac agattttgca tctggtactg tgcaaatagg acagagttta      780

aatggtttag agcagtttgt cggaagaatg caagattttc gattatacca agtggcactt      840

acaaacagag agattctgga agtcttctct ggagatcttc tcagattgca tgcccaatca      900

cattgccgtt gccctggcag ccacccgcgg gtccaccctt tggcacagcg gtactgcatt      960

cctaatgatg caggagacac agctgataat agagtgtcac ggttgaatcc tgaagcccat     1020

cctctctctt ttgtcaatga taatgatgtt ggtacttcat gggtttcaaa tgtgtttaca     1080

aacattacac agcttaatca aggagtgact atttcagttg atttggaaaa tggacagtat     1140

caggtgtttt atattatcat tcagttcttt agtccacaac caacggaaat aaggattcaa     1200

aggaagaagg aaaatagttt agattgggag gactggcaat attttgccag gaattgtggt     1260

gcttttggaa tgaaaaacaa tggagatttg gaaaaacctg attctgtcaa ctgtcttcag     1320

ctttccaatt ttactccata ttcccgtggc aatgtcacat ttagcatcct gacacctgga     1380

ccaaattatc gtcctggata caataacttc tataataccc catctcttca agagttcgta     1440

aaagccacgc aaataaggtt tcattttcat gggcagtact atacaactga gactgctgtt     1500

aacctcagac acagatatta tgcagtggac gaaatcacca ttagtgggag atgtcagtgc     1560

catggtcatg ccgataactg cgacacaaca agccagccat atagatgcct ctgctcccag     1620

gagagcttca ctgaaggact tcattgtgat cgctgcttgc ctctttataa tgacaagcct     1680

ttccgccaag gtgatcaagt ttacgctttc aattgtaaac cttgtcaatg caacagccat     1740

tccaaaagct gccattacaa catctctgta gacccatttc cttttgagca cttcagaggg     1800

ggaggaggag tttgtgatga ttgtgagcat aacactacag gaaggaactg tgagctgtgc     1860

aaggattact ttttccgaca agttggtgca gatccttcgg ccatagatgt ttgcaaaccc     1920

tgtgactgtg atacagttgg cactagaaat ggtagcattc tttgtgatca gattggagga     1980

cagtgtaatt gtaagagaca cgtgtctggc aggcagtgca atcagtgcca gaatggattc     2040

tacaatctac aagagttgga tcctgatggc tgcagtccct gtaactgcaa tacctctggg     2100

acagtggatg gagatattac ctgtcaccaa aattcaggcc agtgcaagtg caaagcaaac     2160

gttattgggc ttaggtgtga tcattgcaat tttggattta aatttctccg aagctttaat     2220

gatgttggat gtgagccctg ccagtgtaac ctccatggct cagtgaacaa attctgcaat     2280

cctcactctg ggcagtgtga gtgcaaaaaa gaagccaaag gacttcagtg tgacacctgc     2340

agagaaaact tttatgggtt agatgtcacc aattgtaagg cctgtgactg tgacacagct     2400

ggatccctcc ctgggactgt ctgtaatgct aagacagggc agtgcatctg caagcccaat     2460

gttgaaggga gacagtgcaa taaatgtttg gagggaaact tctacctacg gcaaaataat     2520

tctttcctct gtctgccttg caactgtgat aagactggga caataaatgg ctctctgctg     2580

tgtaacaaat caacaggaca atgtccttgc aaattagggg taacaggtct tcgctgtaat     2640

cagtgtgagc ctcacaggta caatttgacc attgacaatt ttcaacactg ccagatgtgt     2700

gagtgtgatt ccttggggac attacctggg accatttgtg acccaatcag tggccagtgc     2760

ctgtgtgtgc ctaatcgtca aggaagaagg tgtaatcagt gtcaaccagg tttttatatt     2820

tctccaggca atgccactgg ctgcctgcca tgctcatgcc atacaactgg tgcagttaat     2880

cacatctgta atagcctgac tggtcagtgt gtttgccaag atgcttccat tgctgggcaa     2940

cgttgtgacc aatgcaaaga ccattacttt ggatttgatc ctcagactgg aagatgtcag     3000

ccttgtaatt gtcatctctc aggagccttg aatgaaacct gtcacttggt cacaggccag     3060

tgtttctgta aacaatttgt cactggctca aagtgtgatg cttgtgttcc cagtgcaagc     3120

cacttggatg tcaacaatct attgggttgc agcaaaactc cattccagca acctccgccc     3180

agaggacaag ttcaaagttc ttctgctatc aatctctcct ggagtccacc tgattctcca     3240

aatgcccact ggcttactta cagtttactc agggatggtt ttgaaatcta cacaacagag     3300

gatcaatacc catacagtat tcaatacttc ttagacacag acctgttacc atataccaaa     3360

tattcctatt acattgagac caccaatgtg catggttcaa caaggagtgt agctgtcact     3420

tacaagacaa aaccaggggt cccagaggga aacttgactt taagttatat cattcctatt     3480

ggctcagact ctgtgacact tacctggaca acactctcaa atcaatctgg tcccatagag     3540

aaatatattt tgtcctgtgc ccctttggct ggtggtcagc catgtgtttc ctacgaaggt     3600

catgaaacct cagctaccat ctggaatctg gttccatttg ccaagtacga tttttctgta     3660

caggcgtgta ctagcggggg ctgtttacac agcttgccca ttacagtgac cacagcccag     3720

gcccctcccc aaagactaag tccacctaag atgcagaaaa tcagttctac agaacttcat     3780

gtagaatggt ctccaccagc ggaactaaat ggaataatta taagatatga actatacatg     3840

agaagactga gatctactaa agaaaccaca tctgaggaaa gtcgagtttt tcagagcagt     3900

ggttggctca gtcctcattc atttgtagaa tcggccaatg aaaatgcatt aaaacctcct     3960

caaacaatga caaccatcac tggcttggag ccatacacca agtatgagtt cagagtctta     4020

gctgtgaata tggctggaag tgtgtcttct gcctgggtct cagaaagaac gggagaatca     4080

gcacctgtat tcatgatccc tccttcagtc tttcccctct cttcgtactc tctcaatatc     4140

tcctgggaga agccagcaga taatgttaca agaggaaaag ttgtggggta tgacatcaat     4200

atgctttctg aacaatcacc tcaacagtct attcccatgg cgttttcaca gctgttgcac     4260

actgctaaat cccaagaact atcttacact gtagaaggac tgaaacctta taggatatat     4320

gagtttacta ttactctctg caattcagtt ggttgtgtga ccagtgcttc gggagcagga     4380

caaactttag cagcagcacc agcacaactg aggccacctc tggttaaagg aatcaacagc     4440

acaacaatcc atcttaggtg gtttccacct gaagaactga atggaccctc tcctatatat     4500

cagctggaaa ggagagagtc atctctacca gctctgatga ccacgatgat gaaaggaatc     4560

cgtttcatag gaaatgggta ttgtaaattt cccagctcca ctcacccagt caatacagac     4620

ttcactggca ttaaggccag ctttcgaaca aaagtgcctg aaggtttgat tgtctttgca     4680

gcatcacctg gcaatcagga agagtatttt gcacttcagt tgaagaaggg acgtctttat     4740

tttctttttg atcctcaggg gtcaccagtg gaagtaacta caactaatga tcatggcaaa     4800

caatatagtg atggaaaatg gcatgaaata attgctatta ggcatcaggc ttttggccaa     4860

atcactctgg atgggatata tacaggttcc tctgccatcc tgaatggtag tactgttatt     4920

ggagataaca caggagtctt tctgggaggg ctcccgcgaa gttataccat cctcaggaag     4980

gatcctgaga taatccaaaa aggttttgtg ggctgtctca aggatgtaca ttttatgaag     5040

aattacaatc cgtcagctat ttgggaacct ctggattggc agagttctga agaacaaatc     5100

aacgtgtata acagctggga gggatgtccc gcttcattaa atgagggagc tcagttccta     5160

ggagcagggt tcctggaact tcatccatat atgtttcatg gtggaatgaa ctttgagatt     5220

tcctttaagt tcagaactga ccaattaaat ggattgcttc ttttcgttta taacaaagat     5280

ggacctgatt ttcttgctat ggagctgaaa agtggaatat tgaccttccg gttaaatacc     5340

agtcttgcct ttacacaagt ggatctattg ctggggctat cctattgtaa tggaaagtgg     5400

aataaagtca ttattaaaaa ggaaggctct ttcatatcag caagtgtgaa tggactgatg     5460

aagcatgcat cggagtccgg agaccagcca ctggtggtga attcaccagt ttatgtggga     5520

ggaatcccac aggaactgct gaactcttat caacatttgt gtttggaaca aggtttcggt     5580

ggttgcatga aggatgttaa atttacacgg ggtgctgtcg ttaacttggc atctgtgtcc     5640

agcggtgctg tcagagtcaa tctggatgga tgcctatcaa ctgacagtgc tgttaactgc     5700

aggggaaatg actccatcct ggtttaccag ggaaaagagc agagtgttta cgagggtggt     5760

ctccagcctt ttacagaata cctgtatcga gtgatagcct cgcatgaagg aggttcagta     5820

tatagtgatt ggagtcgagg acgtacaaca ggagcagctc cacaaagtgt gccaactccc     5880

tcaagagtcc gcagcttaaa tggatacagc attgaggtga cctgggatga acctgttgtc     5940

agaggtgtaa ttgagaagta cattctgaaa gcctatagtg aggacagcac ccgtccaccc     6000

cgcatgccct ctgccagtgc tgaatttgtc aatacaagca acctcacagg catattgaca     6060

ggcttgctac ccttcaaaaa ctatgcagta accctaactg cttgcacttt ggctggctgt     6120

actgagagct cacatgcatt gaacatctct actccacaag aagccccaca agaggttcag     6180

ccaccagtag ccaaatccct tcccagttct ttgctgctct cctggaaccc acccaaaaag     6240

gcaaatggta ttataactca gtactgttta tacatggatg ggaggctgat ctattcaggc     6300

agtgaggaga actacatagt cacagattta gcagtattta caccccacca gtttctacta     6360

agtgcatgca cacatgtggg ctgtacaaac agttcctggg tcctactgta cacagcacag     6420

ctgccaccag aacacgtgga ttccccagtt ctgactgtcc tggattctag aactatacac     6480

atacagtgga aacaaccaag aaaaataagt gggattctgg aacgctatgt attatatatg     6540

tcaaaccata cacatgattt tacaatttgg agtgtcatct ataacagtac agaacttttc     6600

caggatcata tgctacaata cgttttacct ggtaataaat atctcatcaa gctgggagct     6660

tgcacaggtg gtgggtgcac agtgagtgag gccagtgagg ccctaactga cgaggacata     6720

cccgaaggcg tgccagcccc caaagcccac tcatattcac ctgactcctt taatgtctcc     6780

tggactgagc ctgaatatcc gaatggtgtt atcacgagtt atggattata tctagatggt     6840

atattaatcc acaattcctc agaactcagc tatcgtgctt acggatttgc tccttggagt     6900

ttacattcct tcagagtcca agcatgcacg gccaaaggtt gtgctctggg cccactggtg     6960

gaaaatcgaa ctctagaagc tcctcctgaa ggaacagtaa atgtgtttgt caaaacacag     7020

ggatcccgga aagcccacgt gaggtgggaa gcaccttttc gccctaatgg actcttaaca     7080

cactcagtcc ttttcactgg gatattctat gtagacccag taggtaataa ctacaccctt     7140

ctgaatgtca caaaagtcat gtacagcgga gaagagacaa acctttgggt gctcatcgat     7200

gggctggttc cttttaccaa ctatactgta caagtgaata tttcaaatag ccaaggcagc     7260

ttgataactg atcctataac aattgcaatg cctccaggag ctccagatgg cgtgctgcct     7320

cccaggcttt catctgccac tccaaccagt cttcaggttg tctggtctac accagctcgt     7380

aataacgctc ctggctctcc cagataccaa ctccagatga ggtctggcga ctccacccat     7440

ggatttctag agttattttc caatccttct gcatcgttaa gctatgaagt gagtgatctc     7500

caaccgtaca cagagtatat gtttcggttg gttgcctcca atggatttgg cagtgcacat     7560

agttcttgga ttccattcat gaccgcagag gacaaacctg gacctgtagt tcctccgatt     7620

cttctggatg tgaagtcaag aatgatgttg gtcacctggc agcatcctag aaaatccaat     7680

ggggttatta cccattataa catttatcta catggccgtc tatacttgag aactcctgga     7740

aatgtcacta attgcacagt gatgcattta cacccataca ctgcctataa gtttcaggta     7800

gaagcctgca cttcaaaagg atgttccctt tcaccagagt cccagactgt atggacactc     7860

ccaggggcac cggaagggat cccaagtcca gagctgttct ctgatactcc aacatctgtg     7920

attatatctt ggcaaccccc tacccacccc aatggcttgg tggagaattt cacaattgag     7980

agaagagtca aaggaaagga agaagttact accctggtga ctctcccgag gagtcattcc     8040

atgaggttta ttgacaagac ttctgctctt agcccatgga caaaatatga atatcgggta     8100

ctgatgagca ctcttcatgg aggcacaaac agcagtgctt gggtagaagt taccacaaga     8160

ccctcacgac ctgctggggt gcagccacct gtggtgacag tgctggaacc cgatgcagtc     8220

caggtcactt ggaaaccccc actcatccag aacggagaca tacttagcta tgagattcac     8280

atgcctgacc ctcacatcac tttaaccaat gtgacttccg cagtgttaag tcaaaaagtt     8340

actcatctga ttcctttcac taattattct gtcaccattg ttgcttgctc agggggtaat     8400

gggtaccttg gagggtgcac agagagttta cctacctatg ttaccactca ccccaccgta     8460

cctcagaatg ttggcccatt gtctgtgatt ccactaagtg aatcatatgt tgtgatttct     8520

tggcaaccac catccaagcc aaatggacct aatttgagat atgagcttct gagacgtaaa     8580

atccagcagc cacttgcatc aaatccccca gaagatttaa atcggtggca caatatttat     8640

tcaggaactc agtggcttta tgaagataag ggtcttagca ggtttacaac ctatgaatat     8700

atgctcttcg tacacaacag tgtgggtttt acaccgagcc gagaagtgac tgtgacaacg     8760

ttagctggtc ttccagagag aggagccaat ctcactgcga gtgtccttaa ccacacagcc     8820

atcgacgtga ggtgggctaa accaactgtt caagacctac aaggtgaagt tgaatattac     8880

acactttttt ggagttctgc tacctcaaac gactctctaa aaatcttgcc agatgtaaac     8940

tctcatgtca ttggccacct aaagccaaac acagagtatt ggatctttat ctctgtcttc     9000

aatggagtcc acagcatcaa cagtgcagga cttcatgcaa ccacttgcga tggggagcct     9060

cagggcatgc ttcctccaga ggttgtcatc atcaacagta cagctgtacg tgtcatctgg     9120

acatctcctt caaacccaaa tggtgttgtc actgagtatt ctatctatgt aaataataag     9180

ctctacaaga ctggaatgaa tgtgcctggg tcgtttattc tgagagacct gtctcccttc     9240

actatctatg acattcaggt tgaagtctgc acaatatatg cctgcgtgaa aagcaatgga     9300

acccaaatta ccactgtgga agacactcca agtgatatac caacacccac aattcgtggc     9360

atcacttcaa gatctcttca aattgattgg gtgtctccac ggaagccaaa tggcatcatt     9420

cttggatatg atctcctatg gaaaacatgg tatccatgcg ctaaaactca aaagttagtg     9480

caggatcaga gtgatgagct ctgcaaggca gtgaggtgtc aaaaacctga atctatctgt     9540

ggacacattt gctattcttc tgaagctaag gtttgttgta acggagtgct ctataacccc     9600

aagcctggac atcgctgttg tgaagaaaag tatatcccgt ttgttctgaa ttctactgga     9660

gtttgttgtg gtggccgaat acaggaggca caaccaaatc atcagtgctg ctctgggtat     9720

tacgctagaa ttctaccagg tgaagtatgc tgtccagatg aacagcacaa tcgggtttct     9780

gttggcattg gtgattcctg ctgtggcaga atgccgtact ccacctcagg aaaccagatt     9840

tgctgtgctg ggaggcttca tgatggccat ggccagaagt gctgtggcag acagattgtg     9900

agcaacgatt tagagtgttg tggtggagaa gaaggagtgg tgtacaatcg ccttccaggt     9960

atgttctgtt gtgggcagga ttatgtgaat atgtcagata ccatatgctg ctcagcttcc    10020

agtggagagt ctaaagcaca tattaaaaag aatgacccgg tgccagtaaa atgctgtgag    10080

actgaactta ttccaaagag ccagaaatgc tgtaatggag ttggatataa tcctttgaaa    10140

tatgtttgct ctgacaagat ttcaactgga atgatgatga aggaaaccaa agagtgcagg    10200

atcctctgcc cagcatctat ggaagccaca gaacattgtg gcaggtgtga cttcaacttt    10260

accagccaca tttgcactgt gataagaggg tctcacaatt ccacagggaa ggcatcaatt    10320

gaagaaatgt gttcatctgc cgaagaaacc attcatacag ggagtgtaaa cacgtactct    10380

tacacagatg tgaacctcaa gccctacatg acatatgagt acaggatttc tgcctggaac    10440

agctatgggc gaggactcag caaagctgtg agagccagaa caaaagaaga tgtgcctcaa    10500

ggagtgagtc cccctacgtg gaccaaaata gacaatcttg aagatacaat tgtcttaaac    10560

tggagaaaac ctatacaatc aaatggtcct attatttact acatccttct tcgaaatgga    10620

attgaacgtt ttcggggaac atcactgagc ttctctgata aagagggaat tcaaccattt    10680

caggaatatt catatcagct gaaagcttgc acggttgctg gctgtgccac cagtagcaag    10740

gtagttgcag ctactaccca aggagttccg gagagcatcc tgccaccaag catcacagcc    10800

ctaagtgcag tggctctgca tctgagctgg agtgtccctg agaaatcaaa cggcgtcatt    10860

aaagagtacc agatcaggca ggttgggaaa ggtctcatcc acactgacac cactgacagg    10920

agacagcata cggtcacagg tctccagcca tacaccaact acagcttcac tcttacagct    10980

tgtacatctg ctgggtgcac ttcaagcgag ccttttctag gtcagacact gcaggcagct    11040

cctgaaggag tttgggtgac acctcgacac attatcatca attctacaac agtggaatta    11100

tattggagtc tgccagaaaa gcccaatggc ctcgtttctc aatatcaatt gagtcgtaat    11160

ggaaacttgc ttttcctggg tggcagtgag gagcagaatt tcactgataa aaacctggag    11220

cccaatagca gatacactta caagttagaa gtcaaaactg gaggtggcag cagtgctagt    11280

gatgattaca ttgttcaaac acctatgtca acaccagaag aaatctatcc tccatataat    11340

atcacagtaa ttgggcctta ttctatattt gtagcttgga taccaccagg gatcctcatc    11400

cccgaaattc ctgtggagta caatgtctta ctcaatgatg gaagtgtaac acctctggcc    11460

ttctccgttg gtcatcatca atccaccctt ctggaaaatt tgactccatt cacacagtat    11520

gagataagga tacaagcatg tcaaaatgga agttgtggag ttagcagtag gatgtttgtc    11580

aaaacacctg aagcagcccc aatggatctt aattctcctg ttcttaaggc actggggtca    11640

gcttgcatag agattaagtg gatgccacct gaaaaaccaa atggaatcat catcaactac    11700

tttatttaca gacgccctgc tggcattgaa gaggagtctg ttttatttgt ctggtcagaa    11760

ggagcccttg aatttatgga tgaaggagac accctgaggc ctttcacact ctacgaatat    11820

cgggtcagag cctgtaactc caagggttca gtggagagtc tgtggtcatt aacacaaact    11880

ctggaagctc cacctcaaga ttttccagct ccttgggctc aagccacgag tgctcattca    11940

gttctgttga attggacaaa gccagaatct cccaatggca ttatctccca ttaccgtgtg    12000

gtctaccagg agagacccga cgatcctaca tttaacagcc ctaccgtgca tgctttcaca    12060

gtgaagggaa caagccatca agcccacctg tacgggttag aaccattcac aacatatcgc    12120

attggtgttg tggctgcaaa ccatgcagga gaaattttaa gcccttggac tctgattcaa    12180

accttagaat cttccccaag tggactgaga aactttatag tagaacagaa agagaatggc    12240

cgggcattgc tactacagtg gtcagaacct atgagaacca atggtgtgat taagacatac    12300

aacatcttca gtgacgggtt cctggagtac tctggtttga atcgtcagtt tctcttccgc    12360

cgcctggatc ctttcactct ctacacactg accctggagg cctgcaccag agcaggttgt    12420

gcacactcgg cgcctcagcc tctgtggaca gatgaagccc ctccagactc tcagctggct    12480

cctactgtcc actctgtgaa gtccaccagt gttgagctga gctggtctga gcctgttaac    12540

ccaaatggaa aaataattcg ctatgaagtg attcgcagat gcttcgaggg aaaagcttgg    12600

ggaaatcaga caatccaggc cgacgagaaa attgttttca cagaatataa cactgaaagg    12660

aatacattta tgtataatga cacaggtttg caaccatgga cgcagtgtga atataaaatc    12720

tacacttgga attcagctgg gcatacctgt agctcttgga atgtggtgag gacattgcaa    12780

gcacctccag aaggtctctc tccacctgtg atatcctatg tttctatgaa tccccaaaaa    12840

ctgctgattt cctggatccc accagaacag tctaatggta ttatccagtc ctataggctt    12900

caaaggaatg aaatgctcta tccttttagc tttgatcctg tgactttcaa ttacactgat    12960

gaagagcttc ttcctttttc cacctatagc tatgcactcc aagcctgcac gagtggagga    13020

tgctccacca gcaaacccac cagcatcaca actctggagg ctgctccatc agaagtcagc    13080

cctccagatc tttgggccgt cagtgccact caaatgaatg tatgttggtc accgcccaca    13140

gtgcaaaatg gaaagattac taaatattta gttagatatg ataataaaga gtcccttgct    13200

ggccagggcc tgtgcctgct ggtttcccac ctgcagcctt actctcagta taacttctcc    13260

cttgtagcct gcacgaatgg aggttgcaca gctagtgtgt caaaatctgc ctggacaatg    13320

gaggccctgc cagagaacat ggactctcca acattgcaag tcacaggctc agaatcaata    13380

gaaatcacct ggaaacctcc aagaaaccca aatggccaga tcagaagtta tgaacttagg    13440

agggatggaa ccattgtata tacaggcttg gaaacacgct atcgtgattt tactctcacc    13500

ccaggtgtgg agtatagcta cacagtaact gccagcaaca gccaaggggg tattttgagt    13560

cctcttgtca aagatcgaac cagcccctca gcaccctcag ggatggaacc tccaaaattg    13620

caggccaggg gtcctcagga gatcttagtg aactgggacc ctccagtgag aacaaatggt    13680

gatatcatca attataccct cttcatccgt gaactatttg aaagagaaac taaaatcata    13740

cacataaaca caactcataa ttcttttggt atgcagtcat atatagtaaa ccagctgaag    13800

ccatttcaca ggtatgaaat acgaattcaa gcgtgcacca ccctgggatg tgcatcaagt    13860

gactggacat tcatacagac ccctgagatt gcacctttga tgcaaccccc tccacatctg    13920

gaggtacaaa tggctccagg aggattccag ccaactgttt ctcttttgtg gacaggaccg    13980

ctgcagccaa atggaaaagt tttgtattac gaattataca gaagacaaat agcaactcag    14040

cctagaaaat ccaatccagt cctaatctat aacggaagct caacatcttt tatagattcc    14100

gaactattgc ctttcacaga gtatgagtat caggtctggg cagtgaattc tgcaggaaaa    14160

gcccccagta gctggacatg gtgcagaacc gggccagccc caccagaagg tctcagagcc    14220

cccacgttcc atgtgatctc ttctacccaa gcagtggtca acatcagtgc ccctgggaag    14280

cccaacggga tcgtcagtct ctacaggctg ttctccagca gcgcccatgg ggctgagaca    14340

gtgctatccg aaggcatggc cacccagcag actctccatg gccttcaagc cttcactaac    14400

tactctattg gagtagaggc ctgcacctgc ttcaactgtt gcagcaaagg accgacagct    14460

gaactgagaa cccatcctgc cccaccctca ggactgtcct ctccacaaat cgggacgctg    14520

gcctcaagga cggcctcctt ccggtggagt ccccccatgt tccccaatgg tgtcattcac    14580

agctatgaac tccaattcca cgtggcttgc cctcctgact cagccctccc ctgtactccc    14640

agccaaatag aaacaaagta cacggggctg gggcagaaag ccagccttgg gggtctccag    14700

ccctacacca catacaagct gagagtggtg gcacacaacg aggtgggcag tacggcttcc    14760

gagtggatca gtttcaccac ccaaaaagaa ttgcctcagt accgagcccc attttcggtg    14820

gacagcaatt tgtctgtggt gtgtgtgaac tggagtgaca ccttcctcct gaacggccaa    14880

ctgaaggagt acgtgttaac cgacggaggg cgacgcgtgt acagcggctt ggacaccacc    14940

ctctacatac cgagaacggc ggacaaaacc ttctttttcc aggtcatctg cacgactgac    15000

gaaggaagtg ttaagacgcc gttgatccaa tatgatacct ctactggact tggcttggtc    15060

ctaacaactc ctgggaaaaa gaagggatcg cggagcaaaa gcacagagtt ctacagcgag    15120

ctgtggttca tagtgttaat ggcgatgctg ggcttgatct tgttggccat ttttctgtcc    15180

ctgatactac aaagaaaaat ccacaaagag ccatatatca gagaaagacc tcccttggta    15240

cctcttcaga agaggatgtc tccattgaat gtttacccac cgggggaaaa ccatatgggg    15300

ttagccgata ccaaaattcc ccggtctggg acacctgtga gtatccgcag caaccggagt    15360

gcatgtgtcc tgcgcatccc gagtcaaaac caaaccagcc taacctactc ccagggttct    15420

cttcaccgca gcgtcagcca gctcatggac attcaagaca agaaagtctt gatggacaac    15480

tcactgtggg aagccatcat gggccacaac agtggactgt atgtggatga agaggacctg    15540

atgaacgcca tcaaggattt cagctcagtg actaaggaac gcaccacatt cacagacacc    15600

cacctg                                                               15606


<210>  3
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  3

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu 
        35                  40  


<210>  4
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  4
atgaattgcc cagttctttc attgggctct ggcttcttgt ttcaggtcat tgaaatgttg       60

atctttgcct attttgcttc aatatccttg actgagtcac gaggtctttt cccaaggctg      120


<210>  5
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  5

Leu Trp Phe Ile Val Leu Met Ala Met Leu Gly Leu Ile Leu Leu Ala 
1               5                   10                  15      


Ile Phe Leu Ser Leu Ile Leu 
            20              


<210>  6
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  6
ctgtggttca tagtgttaat ggcgatgctg ggcttgatct tgttggccat ttttctgtcc       60

ctgatacta                                                               69


<210>  7
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  7

Gln Arg Lys Ile His Lys Glu Pro Tyr Ile Arg Glu Arg Pro Pro Leu 
1               5                   10                  15      


Val Pro Leu Gln Lys Arg Met Ser Pro Leu Asn Val Tyr Pro Pro Gly 
            20                  25                  30          


Glu Asn His Met Gly Leu Ala Asp Thr Lys Ile Pro Arg Ser Gly Thr 
        35                  40                  45              


Pro Val Ser Ile Arg Ser Asn Arg Ser Ala Cys Val Leu Arg Ile Pro 
    50                  55                  60                  


Ser Gln Asn Gln Thr Ser Leu Thr Tyr Ser Gln Gly Ser Leu His Arg 
65                  70                  75                  80  


Ser Val Ser Gln Leu Met Asp Ile Gln Asp Lys Lys Val Leu Met Asp 
                85                  90                  95      


Asn Ser Leu Trp Glu Ala Ile Met Gly His Asn Ser Gly Leu Tyr Val 
            100                 105                 110         


Asp Glu Glu Asp Leu Met Asn Ala Ile Lys Asp Phe Ser Ser Val Thr 
        115                 120                 125             


Lys Glu Arg Thr Thr Phe Thr Asp Thr His Leu 
    130                 135                 


<210>  8
<211>  417
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  8
caaagaaaaa tccacaaaga gccatatatc agagaaagac ctcccttggt acctcttcag       60

aagaggatgt ctccattgaa tgtttaccca ccgggggaaa accatatggg gttagccgat      120

accaaaattc cccggtctgg gacacctgtg agtatccgca gcaaccggag tgcatgtgtc      180

ctgcgcatcc cgagtcaaaa ccaaaccagc ctaacctact cccagggttc tcttcaccgc      240

agcgtcagcc agctcatgga cattcaagac aagaaagtct tgatggacaa ctcactgtgg      300

gaagccatca tgggccacaa cagtggactg tatgtggatg aagaggacct gatgaacgcc      360

atcaaggatt tcagctcagt gactaaggaa cgcaccacat tcacagacac ccacctg         417


<210>  9
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  9

Pro Glu Arg Gly Ala Asn Leu Thr Ala Ser Val Leu Asn His Thr Ala 
1               5                   10                  15      


Ile Asp Val Arg Trp Ala Lys Pro Thr Val Gln Asp Leu Gln Gly Glu 
            20                  25                  30          


Val Glu Tyr Tyr Thr Leu Phe Trp Ser Ser Ala Thr Ser Asn Asp Ser 
        35                  40                  45              


Leu Lys Ile Leu Pro Asp Val Asn Ser His Val Ile Gly His Leu Lys 
    50                  55                  60                  


Pro Asn Thr Glu Tyr Trp Ile Phe Ile Ser Val Phe Asn Gly Val His 
65                  70                  75                  80  


Ser Ile Asn 
            


<210>  10
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  10
ccagagagag gagccaatct cactgcgagt gtccttaacc acacagccat cgacgtgagg       60

tgggctaaac caactgttca agacctacaa ggtgaagttg aatattacac acttttttgg      120

agttctgcta cctcaaacga ctctctaaaa atcttgccag atgtaaactc tcatgtcatt      180

ggccacctaa agccaaacac agagtattgg atctttatct ctgtcttcaa tggagtccac      240

agcatcaac                                                              249


<210>  11
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  11

Pro Gln Gly Met Leu Pro Pro Glu Val Val Ile Ile Asn Ser Thr Ala 
1               5                   10                  15      


Val Arg Val Ile Trp Thr Ser Pro Ser Asn Pro Asn Gly Val Val Thr 
            20                  25                  30          


Glu Tyr Ser Ile Tyr Val Asn Asn Lys Leu Tyr Lys Thr Gly Met Asn 
        35                  40                  45              


Val Pro Gly Ser Phe Ile Leu Arg Asp Leu Ser Pro Phe Thr Ile Tyr 
    50                  55                  60                  


Asp Ile Gln Val Glu Val Cys Thr Ile Tyr Ala Cys Val 
65                  70                  75          


<210>  12
<211>  231
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  12
cctcagggca tgcttcctcc agaggttgtc atcatcaaca gtacagctgt acgtgtcatc       60

tggacatctc cttcaaaccc aaatggtgtt gtcactgagt attctatcta tgtaaataat      120

aagctctaca agactggaat gaatgtgcct gggtcgttta ttctgagaga cctgtctccc      180

ttcactatct atgacattca ggttgaagtc tgcacaatat atgcctgcgt g               231


<210>  13
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  13

Val Ser Pro Pro Thr Trp Thr Lys Ile Asp Asn Leu Glu Asp Thr Ile 
1               5                   10                  15      


Val Leu Asn Trp Arg Lys Pro Ile Gln Ser Asn Gly Pro Ile Ile Tyr 
            20                  25                  30          


Tyr Ile Leu Leu Arg Asn Gly Ile Glu Arg Phe Arg Gly Thr Ser Leu 
        35                  40                  45              


Ser Phe Ser Asp Lys Glu Gly Ile Gln Pro Phe Gln Glu Tyr Ser Tyr 
    50                  55                  60                  


Gln Leu Lys Ala Cys Thr Val Ala Gly Cys Ala 
65                  70                  75  


<210>  14
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  14
gtgagtcccc ctacgtggac caaaatagac aatcttgaag atacaattgt cttaaactgg       60

agaaaaccta tacaatcaaa tggtcctatt atttactaca tccttcttcg aaatggaatt      120

gaacgttttc ggggaacatc actgagcttc tctgataaag agggaattca accatttcag      180

gaatattcat atcagctgaa agcttgcacg gttgctggct gtgcc                      225


<210>  15
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  15

Pro Glu Ser Ile Leu Pro Pro Ser Ile Thr Ala Leu Ser Ala Val Ala 
1               5                   10                  15      


Leu His Leu Ser Trp Ser Val Pro Glu Lys Ser Asn Gly Val Ile Lys 
            20                  25                  30          


Glu Tyr Gln Ile Arg Gln Val Gly Lys Gly Leu Ile His Thr Asp Thr 
        35                  40                  45              


Thr Asp Arg Arg Gln His Thr Val Thr Gly Leu Gln Pro Tyr Thr Asn 
    50                  55                  60                  


Tyr Ser Phe Thr Leu Thr Ala Cys Thr Ser Ala Gly Cys Thr 
65                  70                  75              


<210>  16
<211>  234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  16
ccggagagca tcctgccacc aagcatcaca gccctaagtg cagtggctct gcatctgagc       60

tggagtgtcc ctgagaaatc aaacggcgtc attaaagagt accagatcag gcaggttggg      120

aaaggtctca tccacactga caccactgac aggagacagc atacggtcac aggtctccag      180

ccatacacca actacagctt cactcttaca gcttgtacat ctgctgggtg cact            234


<210>  17
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  17

Pro Glu Gly Val Trp Val Thr Pro Arg His Ile Ile Ile Asn Ser Thr 
1               5                   10                  15      


Thr Val Glu Leu Tyr Trp Ser Leu Pro Glu Lys Pro Asn Gly Leu Val 
            20                  25                  30          


Ser Gln Tyr Gln Leu Ser Arg Asn Gly Asn Leu Leu Phe Leu Gly Gly 
        35                  40                  45              


Ser Glu Glu Gln Asn Phe Thr Asp Lys Asn Leu Glu Pro Asn Ser Arg 
    50                  55                  60                  


Tyr Thr Tyr Lys Leu Glu Val Lys Thr Gly Gly Gly Ser Ser 
65                  70                  75              


<210>  18
<211>  234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  18
cctgaaggag tttgggtgac acctcgacac attatcatca attctacaac agtggaatta       60

tattggagtc tgccagaaaa gcccaatggc ctcgtttctc aatatcaatt gagtcgtaat      120

ggaaacttgc ttttcctggg tggcagtgag gagcagaatt tcactgataa aaacctggag      180

cccaatagca gatacactta caagttagaa gtcaaaactg gaggtggcag cagt            234


<210>  19
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  19

Pro Glu Glu Ile Tyr Pro Pro Tyr Asn Ile Thr Val Ile Gly Pro Tyr 
1               5                   10                  15      


Ser Ile Phe Val Ala Trp Ile Pro Pro Gly Ile Leu Ile Pro Glu Ile 
            20                  25                  30          


Pro Val Glu Tyr Asn Val Leu Leu Asn Asp Gly Ser Val Thr Pro Leu 
        35                  40                  45              


Ala Phe Ser Val Gly His His Gln Ser Thr Leu Leu Glu Asn Leu Thr 
    50                  55                  60                  


Pro Phe Thr Gln Tyr Glu Ile Arg Ile Gln Ala Cys Gln Asn Gly Ser 
65                  70                  75                  80  


Cys Gly Val Ser 
                


<210>  20
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  20
ccagaagaaa tctatcctcc atataatatc acagtaattg ggccttattc tatatttgta       60

gcttggatac caccagggat cctcatcccc gaaattcctg tggagtacaa tgtcttactc      120

aatgatggaa gtgtaacacc tctggccttc tccgttggtc atcatcaatc cacccttctg      180

gaaaatttga ctccattcac acagtatgag ataaggatac aagcatgtca aaatggaagt      240

tgtggagtta gc                                                          252


<210>  21
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  21

Glu Ala Ala Pro Met Asp Leu Asn Ser Pro Val Leu Lys Ala Leu Gly 
1               5                   10                  15      


Ser Ala Cys Ile Glu Ile Lys Trp Met Pro Pro Glu Lys Pro Asn Gly 
            20                  25                  30          


Ile Ile Ile Asn Tyr Phe Ile Tyr Arg Arg Pro Ala Gly Ile Glu Glu 
        35                  40                  45              


Glu Ser Val Leu Phe Val Trp Ser Glu Gly Ala Leu Glu Phe Met Asp 
    50                  55                  60                  


Glu Gly Asp Thr Leu Arg Pro Phe Thr Leu Tyr Glu Tyr Arg Val Arg 
65                  70                  75                  80  


Ala Cys Asn Ser Lys Gly Ser Val 
                85              


<210>  22
<211>  264
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  22
gaagcagccc caatggatct taattctcct gttcttaagg cactggggtc agcttgcata       60

gagattaagt ggatgccacc tgaaaaacca aatggaatca tcatcaacta ctttatttac      120

agacgccctg ctggcattga agaggagtct gttttatttg tctggtcaga aggagccctt      180

gaatttatgg atgaaggaga caccctgagg cctttcacac tctacgaata tcgggtcaga      240

gcctgtaact ccaagggttc agtg                                             264


<210>  23
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  23

Pro Ser Asp Ile Pro Thr Pro Thr Ile Arg Gly Ile Thr Ser Arg Ser 
1               5                   10                  15      


Leu Gln Ile Asp Trp Val Ser Pro Arg Lys Pro Asn Gly Ile Ile Leu 
            20                  25                  30          


Gly Tyr Asp Leu Leu Trp Lys Thr Trp Tyr Pro Cys Ala Lys Thr Gln 
        35                  40                  45              


Lys Leu Val Gln Asp Gln Ser Asp Glu Leu Cys Lys Ala Val Arg Cys 
    50                  55                  60                  


Gln Lys Pro Glu Ser Ile Cys Gly His Ile Cys Tyr Ser Ser Glu Ala 
65                  70                  75                  80  


Lys Val Cys Cys Asn Gly Val Leu Tyr Asn Pro Lys Pro Gly His Arg 
                85                  90                  95      


Cys Cys Glu Glu Lys Tyr Ile Pro Phe Val Leu Asn Ser Thr Gly Val 
            100                 105                 110         


Cys Cys Gly Gly Arg Ile Gln Glu Ala Gln Pro Asn His Gln Cys Cys 
        115                 120                 125             


Ser Gly Tyr Tyr Ala Arg Ile Leu Pro Gly Glu Val Cys Cys Pro Asp 
    130                 135                 140                 


Glu Gln His Asn Arg Val Ser Val Gly Ile Gly Asp Ser Cys Cys Gly 
145                 150                 155                 160 


Arg Met Pro Tyr Ser Thr Ser Gly Asn Gln Ile Cys Cys Ala Gly Arg 
                165                 170                 175     


Leu His Asp Gly His Gly Gln Lys Cys Cys Gly Arg Gln Ile Val Ser 
            180                 185                 190         


Asn Asp Leu Glu Cys Cys Gly Gly Glu Glu Gly Val Val Tyr Asn Arg 
        195                 200                 205             


Leu Pro Gly Met Phe Cys Cys Gly Gln Asp Tyr Val Asn Met Ser Asp 
    210                 215                 220                 


Thr Ile Cys Cys Ser Ala Ser Ser Gly Glu Ser Lys Ala His Ile Lys 
225                 230                 235                 240 


Lys Asn Asp Pro Val Pro Val Lys Cys Cys Glu Thr Glu Leu Ile Pro 
                245                 250                 255     


Lys Ser Gln Lys Cys Cys Asn Gly Val Gly Tyr Asn Pro Leu Lys Tyr 
            260                 265                 270         


Val Cys Ser Asp Lys Ile Ser Thr Gly Met Met Met Lys Glu Thr Lys 
        275                 280                 285             


Glu Cys Arg Ile Leu Cys Pro Ala Ser Met Glu Ala Thr Glu His Cys 
    290                 295                 300                 


Gly Arg Cys Asp Phe Asn Phe Thr Ser His Ile Cys Thr Val Ile Arg 
305                 310                 315                 320 


Gly Ser His Asn Ser Thr Gly Lys Ala Ser Ile Glu Glu Met Cys Ser 
                325                 330                 335     


Ser Ala Glu Glu Thr Ile His Thr Gly Ser Val Asn Thr Tyr Ser Tyr 
            340                 345                 350         


Thr Asp Val Asn Leu Lys Pro Tyr Met Thr Tyr Glu Tyr Arg Ile Ser 
        355                 360                 365             


Ala Trp Asn Ser Tyr Gly Arg Gly 
    370                 375     


<210>  24
<211>  1128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  24
ccaagtgata taccaacacc cacaattcgt ggcatcactt caagatctct tcaaattgat       60

tgggtgtctc cacggaagcc aaatggcatc attcttggat atgatctcct atggaaaaca      120

tggtatccat gcgctaaaac tcaaaagtta gtgcaggatc agagtgatga gctctgcaag      180

gcagtgaggt gtcaaaaacc tgaatctatc tgtggacaca tttgctattc ttctgaagct      240

aaggtttgtt gtaacggagt gctctataac cccaagcctg gacatcgctg ttgtgaagaa      300

aagtatatcc cgtttgttct gaattctact ggagtttgtt gtggtggccg aatacaggag      360

gcacaaccaa atcatcagtg ctgctctggg tattacgcta gaattctacc aggtgaagta      420

tgctgtccag atgaacagca caatcgggtt tctgttggca ttggtgattc ctgctgtggc      480

agaatgccgt actccacctc aggaaaccag atttgctgtg ctgggaggct tcatgatggc      540

catggccaga agtgctgtgg cagacagatt gtgagcaacg atttagagtg ttgtggtgga      600

gaagaaggag tggtgtacaa tcgccttcca ggtatgttct gttgtgggca ggattatgtg      660

aatatgtcag ataccatatg ctgctcagct tccagtggag agtctaaagc acatattaaa      720

aagaatgacc cggtgccagt aaaatgctgt gagactgaac ttattccaaa gagccagaaa      780

tgctgtaatg gagttggata taatcctttg aaatatgttt gctctgacaa gatttcaact      840

ggaatgatga tgaaggaaac caaagagtgc aggatcctct gcccagcatc tatggaagcc      900

acagaacatt gtggcaggtg tgacttcaac tttaccagcc acatttgcac tgtgataaga      960

gggtctcaca attccacagg gaaggcatca attgaagaaa tgtgttcatc tgccgaagaa     1020

accattcata cagggagtgt aaacacgtac tcttacacag atgtgaacct caagccctac     1080

atgacatatg agtacaggat ttctgcctgg aacagctatg ggcgagga                  1128


<210>  25
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  25

Ala Ser Phe Thr Leu Ala Val Trp Leu Lys Pro Glu Gln Gln Gly Val 
1               5                   10                  15      


Met Cys Val Ile Glu Lys Thr Val Asp Gly Gln Ile Val Phe Lys Leu 
            20                  25                  30          


Thr Ile Ser Glu Lys Glu Thr Met Phe Tyr Tyr Arg Thr Val Asn Gly 
        35                  40                  45              


Leu Gln Pro Pro Ile Lys Val Met Thr Leu Gly Arg Ile Leu Val Lys 
    50                  55                  60                  


Lys Trp Ile His Leu Ser Val Gln Val His Gln Thr Lys Ile Ser Phe 
65                  70                  75                  80  


Phe Ile Asn Gly Val Glu Lys Asp His Thr Pro Phe Asn Ala Arg Thr 
                85                  90                  95      


Leu Ser Gly Ser Ile Thr Asp Phe Ala Ser Gly Thr Val Gln Ile Gly 
            100                 105                 110         


Gln Ser Leu Asn Gly Leu Glu Gln Phe Val Gly Arg Met Gln Asp Phe 
        115                 120                 125             


Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg 
    130                 135             


<210>  26
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  26
gcatcattta ccttagctgt atggctgaaa cctgagcaac aaggtgtaat gtgtgttata       60

gaaaagacag tagatgggca gattgtgttc aaacttacaa tatctgagaa agagaccatg      120

ttttattatc gcacagtaaa tggtttgcaa cctccaataa aagtaatgac actggggaga      180

attcttgtga agaaatggat tcatcttagt gtgcaggtgc atcagacaaa aatcagcttc      240

tttatcaatg gcgtggagaa ggatcataca cctttcaatg caagaactct aagtggttca      300

attacagatt ttgcatctgg tactgtgcaa ataggacaga gtttaaatgg tttagagcag      360

tttgtcggaa gaatgcaaga ttttcgatta taccaagtgg cacttacaaa caga            414


<210>  27
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  27

Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg Glu Ile Leu Glu Val Phe 
1               5                   10                  15      


Ser Gly Asp Leu Leu Arg Leu His Ala Gln Ser His Cys Arg Cys Pro 
            20                  25                  30          


Gly Ser His Pro Arg Val His Pro Leu Ala Gln Arg Tyr Cys Ile Pro 
        35                  40                  45              


Asn Asp Ala Gly Asp Thr Ala Asp Asn Arg Val Ser Arg Leu Asn Pro 
    50                  55                  60                  


Glu Ala His Pro Leu Ser Phe Val Asn Asp Asn Asp Val Gly Thr Ser 
65                  70                  75                  80  


Trp Val Ser Asn Val Phe Thr Asn Ile Thr Gln Leu Asn Gln Gly Val 
                85                  90                  95      


Thr Ile Ser Val Asp Leu Glu Asn Gly Gln Tyr Gln Val Phe Tyr Ile 
            100                 105                 110         


Ile Ile Gln Phe Phe Ser Pro Gln Pro Thr Glu Ile Arg Ile Gln Arg 
        115                 120                 125             


Lys Lys Glu Asn Ser Leu Asp Trp Glu Asp Trp Gln Tyr Phe Ala Arg 
    130                 135                 140                 


Asn Cys Gly Ala Phe Gly Met Lys Asn Asn Gly Asp Leu Glu Lys Pro 
145                 150                 155                 160 


Asp Ser Val Asn Cys Leu Gln Leu Ser Asn Phe Thr Pro Tyr Ser Arg 
                165                 170                 175     


Gly Asn Val Thr Phe Ser Ile Leu Thr Pro Gly Pro Asn Tyr Arg Pro 
            180                 185                 190         


Gly Tyr Asn Asn Phe Tyr Asn Thr Pro Ser Leu Gln Glu Phe Val Lys 
        195                 200                 205             


Ala Thr Gln Ile Arg Phe His Phe His Gly Gln Tyr Tyr Thr Thr Glu 
    210                 215                 220                 


Thr Ala Val Asn Leu Arg His Arg Tyr Tyr Ala Val Asp Glu Ile Thr 
225                 230                 235                 240 


Ile Ser Gly 
            


<210>  28
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  28
cgattatacc aagtggcact tacaaacaga gagattctgg aagtcttctc tggagatctt       60

ctcagattgc atgcccaatc acattgccgt tgccctggca gccacccgcg ggtccaccct      120

ttggcacagc ggtactgcat tcctaatgat gcaggagaca cagctgataa tagagtgtca      180

cggttgaatc ctgaagccca tcctctctct tttgtcaatg ataatgatgt tggtacttca      240

tgggtttcaa atgtgtttac aaacattaca cagcttaatc aaggagtgac tatttcagtt      300

gatttggaaa atggacagta tcaggtgttt tatattatca ttcagttctt tagtccacaa      360

ccaacggaaa taaggattca aaggaagaag gaaaatagtt tagattggga ggactggcaa      420

tattttgcca ggaattgtgg tgcttttgga atgaaaaaca atggagattt ggaaaaacct      480

gattctgtca actgtcttca gctttccaat tttactccat attcccgtgg caatgtcaca      540

tttagcatcc tgacacctgg accaaattat cgtcctggat acaataactt ctataatacc      600

ccatctcttc aagagttcgt aaaagccacg caaataaggt ttcattttca tgggcagtac      660

tatacaactg agactgctgt taacctcaga cacagatatt atgcagtgga cgaaatcacc      720

attagtggg                                                              729


<210>  29
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  29

Cys Gln Cys His Gly His Ala Asp Asn Cys Asp Thr Thr Ser Gln Pro 
1               5                   10                  15      


Tyr Arg Cys Leu Cys Ser Gln Glu Ser Phe Thr Glu Gly Leu His Cys 
            20                  25                  30          


Asp Arg Cys Leu Pro Leu Tyr Asn Asp Lys Pro Phe Arg Gln Gly Asp 
        35                  40                  45              


Gln Val Tyr Ala Phe Asn Cys 
    50                  55  


<210>  30
<211>  165
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  30
tgtcagtgcc atggtcatgc cgataactgc gacacaacaa gccagccata tagatgcctc       60

tgctcccagg agagcttcac tgaaggactt cattgtgatc gctgcttgcc tctttataat      120

gacaagcctt tccgccaagg tgatcaagtt tacgctttca attgt                      165


<210>  31
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  31

Cys Gln Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val 
1               5                   10                  15      


Asp Pro Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp 
            20                  25                  30          


Asp Cys Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp 
        35                  40                  45              


Tyr Phe Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys 
    50                  55                  60                  


Cys Gln Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val 
65                  70                  75                  80  


Asp Pro Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp 
                85                  90                  95      


Asp Cys Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp 
            100                 105                 110         


Tyr Phe Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys 
        115                 120                 125             


<210>  32
<211>  192
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  32
tgtcaatgca acagccattc caaaagctgc cattacaaca tctctgtaga cccatttcct       60

tttgagcact tcagaggggg aggaggagtt tgtgatgatt gtgagcataa cactacagga      120

aggaactgtg agctgtgcaa ggattacttt ttccgacaag ttggtgcaga tccttcggcc      180

atagatgttt gc                                                          192


<210>  33
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  33

Cys Asp Cys Asp Thr Val Gly Thr Arg Asn Gly Ser Ile Leu Cys Asp 
1               5                   10                  15      


Gln Ile Gly Gly Gln Cys Asn Cys Lys Arg His Val Ser Gly Arg Gln 
            20                  25                  30          


Cys Asn Gln Cys Gln Asn Gly Phe Tyr Asn Leu Gln Glu Leu Asp Pro 
        35                  40                  45              


Asp Gly Cys 
    50      


<210>  34
<211>  153
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  34
tgtgactgtg atacagttgg cactagaaat ggtagcattc tttgtgatca gattggagga       60

cagtgtaatt gtaagagaca cgtgtctggc aggcagtgca atcagtgcca gaatggattc      120

tacaatctac aagagttgga tcctgatggc tgc                                   153


<210>  35
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  35

Cys Asn Cys Asn Thr Ser Gly Thr Val Asp Gly Asp Ile Thr Cys His 
1               5                   10                  15      


Gln Asn Ser Gly Gln Cys Lys Cys Lys Ala Asn Val Ile Gly Leu Arg 
            20                  25                  30          


Cys Asp His Cys Asn Phe Gly Phe Lys Phe Leu Arg Ser Phe Asn Asp 
        35                  40                  45              


Val Gly Cys 
    50      


<210>  36
<211>  153
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  36
tgtaactgca atacctctgg gacagtggat ggagatatta cctgtcacca aaattcaggc       60

cagtgcaagt gcaaagcaaa cgttattggg cttaggtgtg atcattgcaa ttttggattt      120

aaatttctcc gaagctttaa tgatgttgga tgt                                   153


<210>  37
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  37

Met Asn Phe Glu Ile Ser Phe Lys Phe Arg Thr Asp Gln Leu Asn Gly 
1               5                   10                  15      


Leu Leu Leu Phe Val Tyr Asn Lys Asp Gly Pro Asp Phe Leu Ala Met 
            20                  25                  30          


Glu Leu Lys Ser Gly Ile Leu Thr Phe Arg Leu Asn Thr Ser Leu Ala 
        35                  40                  45              


Phe Thr Gln Val Asp Leu Leu Leu Gly Leu Ser Tyr Cys Asn Gly Lys 
    50                  55                  60                  


Trp Asn Lys Val Ile Ile Lys Lys Glu Gly Ser Phe Ile Ser Ala Ser 
65                  70                  75                  80  


Val Asn Gly Leu Met Lys His Ala Ser Glu Ser Gly Asp Gln Pro Leu 
                85                  90                  95      


Val Val Asn Ser Pro Val Tyr Val Gly Gly Ile Pro Gln Glu Leu Leu 
            100                 105                 110         


Asn Ser Tyr Gln His Leu Cys Leu Glu Gln Gly Phe Gly Gly Cys Met 
        115                 120                 125             


Lys Asp Val Lys Phe Thr Arg Gly 
    130                 135     


<210>  38
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  38
atgaactttg agatttcctt taagttcaga actgaccaat taaatggatt gcttcttttc       60

gtttataaca aagatggacc tgattttctt gctatggagc tgaaaagtgg aatattgacc      120

ttccggttaa ataccagtct tgcctttaca caagtggatc tattgctggg gctatcctat      180

tgtaatggaa agtggaataa agtcattatt aaaaaggaag gctctttcat atcagcaagt      240

gtgaatggac tgatgaagca tgcatcggag tccggagacc agccactggt ggtgaattca      300

ccagtttatg tgggaggaat cccacaggaa ctgctgaact cttatcaaca tttgtgtttg      360

gaacaaggtt tcggtggttg catgaaggat gttaaattta cacggggt                   408


<210>  39
<211>  2262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MiniUSH2A-1

<400>  39

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Lys 
        35                  40                  45              


Val Ser Ile Val Pro Thr Gln Ala Val Cys Gly Leu Pro Asp Arg Ser 
    50                  55                  60                  


Thr Phe Cys His Ser Ser Ala Ala Ala Glu Ser Ile Gln Phe Cys Thr 
65                  70                  75                  80  


Gln Arg Phe Cys Ile Gln Asp Cys Pro Tyr Arg Ser Ser His Pro Thr 
                85                  90                  95      


Tyr Thr Ala Leu Phe Ser Ala Gly Leu Ser Ser Cys Ile Thr Pro Asp 
            100                 105                 110         


Lys Asn Asp Leu His Pro Asn Ala His Ser Asn Ser Ala Ser Phe Ile 
        115                 120                 125             


Phe Gly Asn His Lys Ser Cys Phe Ser Ser Pro Pro Ser Pro Lys Leu 
    130                 135                 140                 


Met Ala Ser Phe Thr Leu Ala Val Trp Leu Lys Pro Glu Gln Gln Gly 
145                 150                 155                 160 


Val Met Cys Val Ile Glu Lys Thr Val Asp Gly Gln Ile Val Phe Lys 
                165                 170                 175     


Leu Thr Ile Ser Glu Lys Glu Thr Met Phe Tyr Tyr Arg Thr Val Asn 
            180                 185                 190         


Gly Leu Gln Pro Pro Ile Lys Val Met Thr Leu Gly Arg Ile Leu Val 
        195                 200                 205             


Lys Lys Trp Ile His Leu Ser Val Gln Val His Gln Thr Lys Ile Ser 
    210                 215                 220                 


Phe Phe Ile Asn Gly Val Glu Lys Asp His Thr Pro Phe Asn Ala Arg 
225                 230                 235                 240 


Thr Leu Ser Gly Ser Ile Thr Asp Phe Ala Ser Gly Thr Val Gln Ile 
                245                 250                 255     


Gly Gln Ser Leu Asn Gly Leu Glu Gln Phe Val Gly Arg Met Gln Asp 
            260                 265                 270         


Phe Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg Glu Ile Leu Glu Val 
        275                 280                 285             


Phe Ser Gly Asp Leu Leu Arg Leu His Ala Gln Ser His Cys Arg Cys 
    290                 295                 300                 


Pro Gly Ser His Pro Arg Val His Pro Leu Ala Gln Arg Tyr Cys Ile 
305                 310                 315                 320 


Pro Asn Asp Ala Gly Asp Thr Ala Asp Asn Arg Val Ser Arg Leu Asn 
                325                 330                 335     


Pro Glu Ala His Pro Leu Ser Phe Val Asn Asp Asn Asp Val Gly Thr 
            340                 345                 350         


Ser Trp Val Ser Asn Val Phe Thr Asn Ile Thr Gln Leu Asn Gln Gly 
        355                 360                 365             


Val Thr Ile Ser Val Asp Leu Glu Asn Gly Gln Tyr Gln Val Phe Tyr 
    370                 375                 380                 


Ile Ile Ile Gln Phe Phe Ser Pro Gln Pro Thr Glu Ile Arg Ile Gln 
385                 390                 395                 400 


Arg Lys Lys Glu Asn Ser Leu Asp Trp Glu Asp Trp Gln Tyr Phe Ala 
                405                 410                 415     


Arg Asn Cys Gly Ala Phe Gly Met Lys Asn Asn Gly Asp Leu Glu Lys 
            420                 425                 430         


Pro Asp Ser Val Asn Cys Leu Gln Leu Ser Asn Phe Thr Pro Tyr Ser 
        435                 440                 445             


Arg Gly Asn Val Thr Phe Ser Ile Leu Thr Pro Gly Pro Asn Tyr Arg 
    450                 455                 460                 


Pro Gly Tyr Asn Asn Phe Tyr Asn Thr Pro Ser Leu Gln Glu Phe Val 
465                 470                 475                 480 


Lys Ala Thr Gln Ile Arg Phe His Phe His Gly Gln Tyr Tyr Thr Thr 
                485                 490                 495     


Glu Thr Ala Val Asn Leu Arg His Arg Tyr Tyr Ala Val Asp Glu Ile 
            500                 505                 510         


Thr Ile Ser Gly Arg Cys Gln Cys His Gly His Ala Asp Asn Cys Asp 
        515                 520                 525             


Thr Thr Ser Gln Pro Tyr Arg Cys Leu Cys Ser Gln Glu Ser Phe Thr 
    530                 535                 540                 


Glu Gly Leu His Cys Asp Arg Cys Leu Pro Leu Tyr Asn Asp Lys Pro 
545                 550                 555                 560 


Phe Arg Gln Gly Asp Gln Val Tyr Ala Phe Asn Cys Lys Pro Cys Gln 
                565                 570                 575     


Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val Asp Pro 
            580                 585                 590         


Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp Asp Cys 
        595                 600                 605             


Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp Tyr Phe 
    610                 615                 620                 


Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys Lys Pro 
625                 630                 635                 640 


Cys Asp Cys Asp Thr Val Gly Thr Arg Asn Gly Ser Ile Leu Cys Asp 
                645                 650                 655     


Gln Ile Gly Gly Gln Cys Asn Cys Lys Arg His Val Ser Gly Arg Gln 
            660                 665                 670         


Cys Asn Gln Cys Gln Asn Gly Phe Tyr Asn Leu Gln Glu Leu Asp Pro 
        675                 680                 685             


Asp Gly Cys Ser Pro Cys Asn Cys Asn Thr Ser Gly Thr Val Asp Gly 
    690                 695                 700                 


Asp Ile Thr Cys His Gln Asn Ser Gly Gln Cys Lys Cys Lys Ala Asn 
705                 710                 715                 720 


Val Ile Gly Leu Arg Cys Asp His Cys Asn Phe Gly Phe Lys Phe Leu 
                725                 730                 735     


Arg Ser Phe Asn Asp Val Gly Cys Tyr Asn Pro Ser Ala Ile Trp Glu 
            740                 745                 750         


Pro Leu Asp Trp Gln Ser Ser Glu Glu Gln Ile Asn Val Tyr Asn Ser 
        755                 760                 765             


Trp Glu Gly Cys Pro Ala Ser Leu Asn Glu Gly Ala Gln Phe Leu Gly 
    770                 775                 780                 


Ala Gly Phe Leu Glu Leu His Pro Tyr Met Phe His Gly Gly Met Asn 
785                 790                 795                 800 


Phe Glu Ile Ser Phe Lys Phe Arg Thr Asp Gln Leu Asn Gly Leu Leu 
                805                 810                 815     


Leu Phe Val Tyr Asn Lys Asp Gly Pro Asp Phe Leu Ala Met Glu Leu 
            820                 825                 830         


Lys Ser Gly Ile Leu Thr Phe Arg Leu Asn Thr Ser Leu Ala Phe Thr 
        835                 840                 845             


Gln Val Asp Leu Leu Leu Gly Leu Ser Tyr Cys Asn Gly Lys Trp Asn 
    850                 855                 860                 


Lys Val Ile Ile Lys Lys Glu Gly Ser Phe Ile Ser Ala Ser Val Asn 
865                 870                 875                 880 


Gly Leu Met Lys His Ala Ser Glu Ser Gly Asp Gln Pro Leu Val Val 
                885                 890                 895     


Asn Ser Pro Val Tyr Val Gly Gly Ile Pro Gln Glu Leu Leu Asn Ser 
            900                 905                 910         


Tyr Gln His Leu Cys Leu Glu Gln Gly Phe Gly Gly Cys Met Lys Asp 
        915                 920                 925             


Val Lys Phe Thr Arg Gly Pro Ser Arg Glu Val Thr Val Thr Thr Leu 
    930                 935                 940                 


Ala Gly Leu Pro Glu Arg Gly Ala Asn Leu Thr Ala Ser Val Leu Asn 
945                 950                 955                 960 


His Thr Ala Ile Asp Val Arg Trp Ala Lys Pro Thr Val Gln Asp Leu 
                965                 970                 975     


Gln Gly Glu Val Glu Tyr Tyr Thr Leu Phe Trp Ser Ser Ala Thr Ser 
            980                 985                 990         


Asn Asp Ser Leu Lys Ile Leu Pro  Asp Val Asn Ser His  Val Ile Gly 
        995                 1000                 1005             


His Leu  Lys Pro Asn Thr Glu  Tyr Trp Ile Phe Ile  Ser Val Phe 
    1010                 1015                 1020             


Asn Gly  Val His Ser Ile Asn  Ser Ala Gly Leu His  Ala Thr Thr 
    1025                 1030                 1035             


Cys Asp  Gly Glu Pro Gln Gly  Met Leu Pro Pro Glu  Val Val Ile 
    1040                 1045                 1050             


Ile Asn  Ser Thr Ala Val Arg  Val Ile Trp Thr Ser  Pro Ser Asn 
    1055                 1060                 1065             


Pro Asn  Gly Val Val Thr Glu  Tyr Ser Ile Tyr Val  Asn Asn Lys 
    1070                 1075                 1080             


Leu Tyr  Lys Thr Gly Met Asn  Val Pro Gly Ser Phe  Ile Leu Arg 
    1085                 1090                 1095             


Asp Leu  Ser Pro Phe Thr Ile  Tyr Asp Ile Gln Val  Glu Val Cys 
    1100                 1105                 1110             


Thr Ile  Tyr Ala Cys Val Lys  Ser Asn Gly Thr Gln  Ile Thr Thr 
    1115                 1120                 1125             


Val Glu  Asp Thr Pro Ser Asp  Ile Pro Thr Pro Thr  Ile Arg Gly 
    1130                 1135                 1140             


Ile Thr  Ser Arg Ser Leu Gln  Ile Asp Trp Val Ser  Pro Arg Lys 
    1145                 1150                 1155             


Pro Asn  Gly Ile Ile Leu Gly  Tyr Asp Leu Leu Trp  Lys Thr Trp 
    1160                 1165                 1170             


Tyr Pro  Cys Ala Lys Thr Gln  Lys Leu Val Gln Asp  Gln Ser Asp 
    1175                 1180                 1185             


Glu Leu  Cys Lys Ala Val Arg  Cys Gln Lys Pro Glu  Ser Ile Cys 
    1190                 1195                 1200             


Gly His  Ile Cys Tyr Ser Ser  Glu Ala Lys Val Cys  Cys Asn Gly 
    1205                 1210                 1215             


Val Leu  Tyr Asn Pro Lys Pro  Gly His Arg Cys Cys  Glu Glu Lys 
    1220                 1225                 1230             


Tyr Ile  Pro Phe Val Leu Asn  Ser Thr Gly Val Cys  Cys Gly Gly 
    1235                 1240                 1245             


Arg Ile  Gln Glu Ala Gln Pro  Asn His Gln Cys Cys  Ser Gly Tyr 
    1250                 1255                 1260             


Tyr Ala  Arg Ile Leu Pro Gly  Glu Val Cys Cys Pro  Asp Glu Gln 
    1265                 1270                 1275             


His Asn  Arg Val Ser Val Gly  Ile Gly Asp Ser Cys  Cys Gly Arg 
    1280                 1285                 1290             


Met Pro  Tyr Ser Thr Ser Gly  Asn Gln Ile Cys Cys  Ala Gly Arg 
    1295                 1300                 1305             


Leu His  Asp Gly His Gly Gln  Lys Cys Cys Gly Arg  Gln Ile Val 
    1310                 1315                 1320             


Ser Asn  Asp Leu Glu Cys Cys  Gly Gly Glu Glu Gly  Val Val Tyr 
    1325                 1330                 1335             


Asn Arg  Leu Pro Gly Met Phe  Cys Cys Gly Gln Asp  Tyr Val Asn 
    1340                 1345                 1350             


Met Ser  Asp Thr Ile Cys Cys  Ser Ala Ser Ser Gly  Glu Ser Lys 
    1355                 1360                 1365             


Ala His  Ile Lys Lys Asn Asp  Pro Val Pro Val Lys  Cys Cys Glu 
    1370                 1375                 1380             


Thr Glu  Leu Ile Pro Lys Ser  Gln Lys Cys Cys Asn  Gly Val Gly 
    1385                 1390                 1395             


Tyr Asn  Pro Leu Lys Tyr Val  Cys Ser Asp Lys Ile  Ser Thr Gly 
    1400                 1405                 1410             


Met Met  Met Lys Glu Thr Lys  Glu Cys Arg Ile Leu  Cys Pro Ala 
    1415                 1420                 1425             


Ser Met  Glu Ala Thr Glu His  Cys Gly Arg Cys Asp  Phe Asn Phe 
    1430                 1435                 1440             


Thr Ser  His Ile Cys Thr Val  Ile Arg Gly Ser His  Asn Ser Thr 
    1445                 1450                 1455             


Gly Lys  Ala Ser Ile Glu Glu  Met Cys Ser Ser Ala  Glu Glu Thr 
    1460                 1465                 1470             


Ile His  Thr Gly Ser Val Asn  Thr Tyr Ser Tyr Thr  Asp Val Asn 
    1475                 1480                 1485             


Leu Lys  Pro Tyr Met Thr Tyr  Glu Tyr Arg Ile Ser  Ala Trp Asn 
    1490                 1495                 1500             


Ser Tyr  Gly Arg Gly Leu Ser  Lys Ala Val Arg Ala  Arg Thr Lys 
    1505                 1510                 1515             


Glu Asp  Val Pro Gln Gly Val  Ser Pro Pro Thr Trp  Thr Lys Ile 
    1520                 1525                 1530             


Asp Asn  Leu Glu Asp Thr Ile  Val Leu Asn Trp Arg  Lys Pro Ile 
    1535                 1540                 1545             


Gln Ser  Asn Gly Pro Ile Ile  Tyr Tyr Ile Leu Leu  Arg Asn Gly 
    1550                 1555                 1560             


Ile Glu  Arg Phe Arg Gly Thr  Ser Leu Ser Phe Ser  Asp Lys Glu 
    1565                 1570                 1575             


Gly Ile  Gln Pro Phe Gln Glu  Tyr Ser Tyr Gln Leu  Lys Ala Cys 
    1580                 1585                 1590             


Thr Val  Ala Gly Cys Ala Thr  Ser Ser Lys Val Val  Ala Ala Thr 
    1595                 1600                 1605             


Thr Gln  Gly Val Pro Glu Ser  Ile Leu Pro Pro Ser  Ile Thr Ala 
    1610                 1615                 1620             


Leu Ser  Ala Val Ala Leu His  Leu Ser Trp Ser Val  Pro Glu Lys 
    1625                 1630                 1635             


Ser Asn  Gly Val Ile Lys Glu  Tyr Gln Ile Arg Gln  Val Gly Lys 
    1640                 1645                 1650             


Gly Leu  Ile His Thr Asp Thr  Thr Asp Arg Arg Gln  His Thr Val 
    1655                 1660                 1665             


Thr Gly  Leu Gln Pro Tyr Thr  Asn Tyr Ser Phe Thr  Leu Thr Ala 
    1670                 1675                 1680             


Cys Thr  Ser Ala Gly Cys Thr  Ser Ser Glu Pro Phe  Leu Gly Gln 
    1685                 1690                 1695             


Thr Leu  Gln Ala Ala Pro Glu  Gly Val Trp Val Thr  Pro Arg His 
    1700                 1705                 1710             


Ile Ile  Ile Asn Ser Thr Thr  Val Glu Leu Tyr Trp  Ser Leu Pro 
    1715                 1720                 1725             


Glu Lys  Pro Asn Gly Leu Val  Ser Gln Tyr Gln Leu  Ser Arg Asn 
    1730                 1735                 1740             


Gly Asn  Leu Leu Phe Leu Gly  Gly Ser Glu Glu Gln  Asn Phe Thr 
    1745                 1750                 1755             


Asp Lys  Asn Leu Glu Pro Asn  Ser Arg Tyr Thr Tyr  Lys Leu Glu 
    1760                 1765                 1770             


Val Lys  Thr Gly Gly Gly Ser  Ser Ala Ser Asp Asp  Tyr Ile Val 
    1775                 1780                 1785             


Gln Thr  Pro Met Ser Thr Pro  Glu Glu Ile Tyr Pro  Pro Tyr Asn 
    1790                 1795                 1800             


Ile Thr  Val Ile Gly Pro Tyr  Ser Ile Phe Val Ala  Trp Ile Pro 
    1805                 1810                 1815             


Pro Gly  Ile Leu Ile Pro Glu  Ile Pro Val Glu Tyr  Asn Val Leu 
    1820                 1825                 1830             


Leu Asn  Asp Gly Ser Val Thr  Pro Leu Ala Phe Ser  Val Gly His 
    1835                 1840                 1845             


His Gln  Ser Thr Leu Leu Glu  Asn Leu Thr Pro Phe  Thr Gln Tyr 
    1850                 1855                 1860             


Glu Ile  Arg Ile Gln Ala Cys  Gln Asn Gly Ser Cys  Gly Val Ser 
    1865                 1870                 1875             


Ser Arg  Met Phe Val Lys Thr  Pro Glu Ala Ala Pro  Met Asp Leu 
    1880                 1885                 1890             


Asn Ser  Pro Val Leu Lys Ala  Leu Gly Ser Ala Cys  Ile Glu Ile 
    1895                 1900                 1905             


Lys Trp  Met Pro Pro Glu Lys  Pro Asn Gly Ile Ile  Ile Asn Tyr 
    1910                 1915                 1920             


Phe Ile  Tyr Arg Arg Pro Ala  Gly Ile Glu Glu Glu  Ser Val Leu 
    1925                 1930                 1935             


Phe Val  Trp Ser Glu Gly Ala  Leu Glu Phe Met Asp  Glu Gly Asp 
    1940                 1945                 1950             


Thr Leu  Arg Pro Phe Thr Leu  Tyr Glu Tyr Arg Val  Arg Ala Cys 
    1955                 1960                 1965             


Asn Ser  Lys Gly Ser Val Glu  Ser Leu Trp Ala Ser  Glu Trp Ile 
    1970                 1975                 1980             


Ser Phe  Thr Thr Gln Lys Glu  Leu Pro Gln Tyr Arg  Ala Pro Phe 
    1985                 1990                 1995             


Ser Val  Asp Ser Asn Leu Ser  Val Val Cys Val Asn  Trp Ser Asp 
    2000                 2005                 2010             


Thr Phe  Leu Leu Asn Gly Gln  Leu Lys Glu Tyr Val  Leu Thr Asp 
    2015                 2020                 2025             


Gly Gly  Arg Arg Val Tyr Ser  Gly Leu Asp Thr Thr  Leu Tyr Ile 
    2030                 2035                 2040             


Pro Arg  Thr Ala Asp Lys Thr  Phe Phe Phe Gln Val  Ile Cys Thr 
    2045                 2050                 2055             


Thr Asp  Glu Gly Ser Val Lys  Thr Pro Leu Ile Gln  Tyr Asp Thr 
    2060                 2065                 2070             


Ser Thr  Gly Leu Gly Leu Val  Leu Thr Thr Pro Gly  Lys Lys Lys 
    2075                 2080                 2085             


Gly Ser  Arg Ser Lys Ser Thr  Glu Phe Tyr Ser Glu  Leu Trp Phe 
    2090                 2095                 2100             


Ile Val  Leu Met Ala Met Leu  Gly Leu Ile Leu Leu  Ala Ile Phe 
    2105                 2110                 2115             


Leu Ser  Leu Ile Leu Gln Arg  Lys Ile His Lys Glu  Pro Tyr Ile 
    2120                 2125                 2130             


Arg Glu  Arg Pro Pro Leu Val  Pro Leu Gln Lys Arg  Met Ser Pro 
    2135                 2140                 2145             


Leu Asn  Val Tyr Pro Pro Gly  Glu Asn His Met Gly  Leu Ala Asp 
    2150                 2155                 2160             


Thr Lys  Ile Pro Arg Ser Gly  Thr Pro Val Ser Ile  Arg Ser Asn 
    2165                 2170                 2175             


Arg Ser  Ala Cys Val Leu Arg  Ile Pro Ser Gln Asn  Gln Thr Ser 
    2180                 2185                 2190             


Leu Thr  Tyr Ser Gln Gly Ser  Leu His Arg Ser Val  Ser Gln Leu 
    2195                 2200                 2205             


Met Asp  Ile Gln Asp Lys Lys  Val Leu Met Asp Asn  Ser Leu Trp 
    2210                 2215                 2220             


Glu Ala  Ile Met Gly His Asn  Ser Gly Leu Tyr Val  Asp Glu Glu 
    2225                 2230                 2235             


Asp Leu  Met Asn Ala Ile Lys  Asp Phe Ser Ser Val  Thr Lys Glu 
    2240                 2245                 2250             


Arg Thr  Thr Phe Thr Asp Thr  His Leu 
    2255                 2260         


<210>  40
<211>  6786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiniUSH2A-1

<400>  40
atgaattgcc cagttctttc attgggctct ggcttcttgt ttcaggtcat tgaaatgttg       60

atctttgcct attttgcttc aatatccttg actgagtcac gaggtctttt cccaaggctg      120

gagaacgtgg gagctttcaa gaaagtttcc atcgtgccaa cccaagcagt atgtggactc      180

ccagaccgaa gcactttttg tcacagctct gctgctgctg aaagtattca gttctgtacc      240

cagcggtttt gtattcagga ttgcccatac agatcttcac accctaccta cactgccctt      300

ttctcagcag gcctcagtag ctgcatcaca ccagacaaga atgatctgca tcctaacgcc      360

catagcaatt ctgcaagttt tatttttgga aatcacaaga gctgcttttc ttctcctcct      420

tctccaaagc tgatggcatc atttacctta gctgtatggc tgaaacctga gcaacaaggt      480

gtaatgtgtg ttatagaaaa gacagtagat gggcagattg tgttcaaact tacaatatct      540

gagaaagaga ccatgtttta ttatcgcaca gtaaatggtt tgcaacctcc aataaaagta      600

atgacactgg ggagaattct tgtgaagaaa tggattcatc ttagtgtgca ggtgcatcag      660

acaaaaatca gcttctttat caatggcgtg gagaaggatc atacaccttt caatgcaaga      720

actctaagtg gttcaattac agattttgca tctggtactg tgcaaatagg acagagttta      780

aatggtttag agcagtttgt cggaagaatg caagattttc gattatacca agtggcactt      840

acaaacagag agattctgga agtcttctct ggagatcttc tcagattgca tgcccaatca      900

cattgccgtt gccctggcag ccacccgcgg gtccaccctt tggcacagcg gtactgcatt      960

cctaatgatg caggagacac agctgataat agagtgtcac ggttgaatcc tgaagcccat     1020

cctctctctt ttgtcaatga taatgatgtt ggtacttcat gggtttcaaa tgtgtttaca     1080

aacattacac agcttaatca aggagtgact atttcagttg atttggaaaa tggacagtat     1140

caggtgtttt atattatcat tcagttcttt agtccacaac caacggaaat aaggattcaa     1200

aggaagaagg aaaatagttt agattgggag gactggcaat attttgccag gaattgtggt     1260

gcttttggaa tgaaaaacaa tggagatttg gaaaaacctg attctgtcaa ctgtcttcag     1320

ctttccaatt ttactccata ttcccgtggc aatgtcacat ttagcatcct gacacctgga     1380

ccaaattatc gtcctggata caataacttc tataataccc catctcttca agagttcgta     1440

aaagccacgc aaataaggtt tcattttcat gggcagtact atacaactga gactgctgtt     1500

aacctcagac acagatatta tgcagtggac gaaatcacca ttagtgggag atgtcagtgc     1560

catggtcatg ccgataactg cgacacaaca agccagccat atagatgcct ctgctcccag     1620

gagagcttca ctgaaggact tcattgtgat cgctgcttgc ctctttataa tgacaagcct     1680

ttccgccaag gtgatcaagt ttacgctttc aattgtaaac cttgtcaatg caacagccat     1740

tccaaaagct gccattacaa catctctgta gacccatttc cttttgagca cttcagaggg     1800

ggaggaggag tttgtgatga ttgtgagcat aacactacag gaaggaactg tgagctgtgc     1860

aaggattact ttttccgaca agttggtgca gatccttcgg ccatagatgt ttgcaaaccc     1920

tgtgactgtg atacagttgg cactagaaat ggtagcattc tttgtgatca gattggagga     1980

cagtgtaatt gtaagagaca cgtgtctggc aggcagtgca atcagtgcca gaatggattc     2040

tacaatctac aagagttgga tcctgatggc tgcagtccct gtaactgcaa tacctctggg     2100

acagtggatg gagatattac ctgtcaccaa aattcaggcc agtgcaagtg caaagcaaac     2160

gttattgggc ttaggtgtga tcattgcaat tttggattta aatttctccg aagctttaat     2220

gatgttggat gttacaatcc gtcagctatt tgggaacctc tggattggca gagttctgaa     2280

gaacaaatca acgtgtataa cagctgggag ggatgtcccg cttcattaaa tgagggagct     2340

cagttcctag gagcagggtt cctggaactt catccatata tgtttcatgg tggaatgaac     2400

tttgagattt cctttaagtt cagaactgac caattaaatg gattgcttct tttcgtttat     2460

aacaaagatg gacctgattt tcttgctatg gagctgaaaa gtggaatatt gaccttccgg     2520

ttaaatacca gtcttgcctt tacacaagtg gatctattgc tggggctatc ctattgtaat     2580

ggaaagtgga ataaagtcat tattaaaaag gaaggctctt tcatatcagc aagtgtgaat     2640

ggactgatga agcatgcatc ggagtccgga gaccagccac tggtggtgaa ttcaccagtt     2700

tatgtgggag gaatcccaca ggaactgctg aactcttatc aacatttgtg tttggaacaa     2760

ggtttcggtg gttgcatgaa ggatgttaaa tttacacggg gtccgagccg agaagtgact     2820

gtgacaacgt tagctggtct tccagagaga ggagccaatc tcactgcgag tgtccttaac     2880

cacacagcca tcgacgtgag gtgggctaaa ccaactgttc aagacctaca aggtgaagtt     2940

gaatattaca cacttttttg gagttctgct acctcaaacg actctctaaa aatcttgcca     3000

gatgtaaact ctcatgtcat tggccaccta aagccaaaca cagagtattg gatctttatc     3060

tctgtcttca atggagtcca cagcatcaac agtgcaggac ttcatgcaac cacttgcgat     3120

ggggagcctc agggcatgct tcctccagag gttgtcatca tcaacagtac agctgtacgt     3180

gtcatctgga catctccttc aaacccaaat ggtgttgtca ctgagtattc tatctatgta     3240

aataataagc tctacaagac tggaatgaat gtgcctgggt cgtttattct gagagacctg     3300

tctcccttca ctatctatga cattcaggtt gaagtctgca caatatatgc ctgcgtgaaa     3360

agcaatggaa cccaaattac cactgtggaa gacactccaa gtgatatacc aacacccaca     3420

attcgtggca tcacttcaag atctcttcaa attgattggg tgtctccacg gaagccaaat     3480

ggcatcattc ttggatatga tctcctatgg aaaacatggt atccatgcgc taaaactcaa     3540

aagttagtgc aggatcagag tgatgagctc tgcaaggcag tgaggtgtca aaaacctgaa     3600

tctatctgtg gacacatttg ctattcttct gaagctaagg tttgttgtaa cggagtgctc     3660

tataacccca agcctggaca tcgctgttgt gaagaaaagt atatcccgtt tgttctgaat     3720

tctactggag tttgttgtgg tggccgaata caggaggcac aaccaaatca tcagtgctgc     3780

tctgggtatt acgctagaat tctaccaggt gaagtatgct gtccagatga acagcacaat     3840

cgggtttctg ttggcattgg tgattcctgc tgtggcagaa tgccgtactc cacctcagga     3900

aaccagattt gctgtgctgg gaggcttcat gatggccatg gccagaagtg ctgtggcaga     3960

cagattgtga gcaacgattt agagtgttgt ggtggagaag aaggagtggt gtacaatcgc     4020

cttccaggta tgttctgttg tgggcaggat tatgtgaata tgtcagatac catatgctgc     4080

tcagcttcca gtggagagtc taaagcacat attaaaaaga atgacccggt gccagtaaaa     4140

tgctgtgaga ctgaacttat tccaaagagc cagaaatgct gtaatggagt tggatataat     4200

cctttgaaat atgtttgctc tgacaagatt tcaactggaa tgatgatgaa ggaaaccaaa     4260

gagtgcagga tcctctgccc agcatctatg gaagccacag aacattgtgg caggtgtgac     4320

ttcaacttta ccagccacat ttgcactgtg ataagagggt ctcacaattc cacagggaag     4380

gcatcaattg aagaaatgtg ttcatctgcc gaagaaacca ttcatacagg gagtgtaaac     4440

acgtactctt acacagatgt gaacctcaag ccctacatga catatgagta caggatttct     4500

gcctggaaca gctatgggcg aggactcagc aaagctgtga gagccagaac aaaagaagat     4560

gtgcctcaag gagtgagtcc ccctacgtgg accaaaatag acaatcttga agatacaatt     4620

gtcttaaact ggagaaaacc tatacaatca aatggtccta ttatttacta catccttctt     4680

cgaaatggaa ttgaacgttt tcggggaaca tcactgagct tctctgataa agagggaatt     4740

caaccatttc aggaatattc atatcagctg aaagcttgca cggttgctgg ctgtgccacc     4800

agtagcaagg tagttgcagc tactacccaa ggagttccgg agagcatcct gccaccaagc     4860

atcacagccc taagtgcagt ggctctgcat ctgagctgga gtgtccctga gaaatcaaac     4920

ggcgtcatta aagagtacca gatcaggcag gttgggaaag gtctcatcca cactgacacc     4980

actgacagga gacagcatac ggtcacaggt ctccagccat acaccaacta cagcttcact     5040

cttacagctt gtacatctgc tgggtgcact tcaagcgagc cttttctagg tcagacactg     5100

caggcagctc ctgaaggagt ttgggtgaca cctcgacaca ttatcatcaa ttctacaaca     5160

gtggaattat attggagtct gccagaaaag cccaatggcc tcgtttctca atatcaattg     5220

agtcgtaatg gaaacttgct tttcctgggt ggcagtgagg agcagaattt cactgataaa     5280

aacctggagc ccaatagcag atacacttac aagttagaag tcaaaactgg aggtggcagc     5340

agtgctagtg atgattacat tgttcaaaca cctatgtcaa caccagaaga aatctatcct     5400

ccatataata tcacagtaat tgggccttat tctatatttg tagcttggat accaccaggg     5460

atcctcatcc ccgaaattcc tgtggagtac aatgtcttac tcaatgatgg aagtgtaaca     5520

cctctggcct tctccgttgg tcatcatcaa tccacccttc tggaaaattt gactccattc     5580

acacagtatg agataaggat acaagcatgt caaaatggaa gttgtggagt tagcagtagg     5640

atgtttgtca aaacacctga agcagcccca atggatctta attctcctgt tcttaaggca     5700

ctggggtcag cttgcataga gattaagtgg atgccacctg aaaaaccaaa tggaatcatc     5760

atcaactact ttatttacag acgccctgct ggcattgaag aggagtctgt tttatttgtc     5820

tggtcagaag gagcccttga atttatggat gaaggagaca ccctgaggcc tttcacactc     5880

tacgaatatc gggtcagagc ctgtaactcc aagggttcag tggagagtct gtgggcttcc     5940

gagtggatca gtttcaccac ccaaaaagaa ttgcctcagt accgagcccc attttcggtg     6000

gacagcaatt tgtctgtggt gtgtgtgaac tggagtgaca ccttcctcct gaacggccaa     6060

ctgaaggagt acgtgttaac cgacggaggg cgacgcgtgt acagcggctt ggacaccacc     6120

ctctacatac cgagaacggc ggacaaaacc ttctttttcc aggtcatctg cacgactgac     6180

gaaggaagtg ttaagacgcc gttgatccaa tatgatacct ctactggact tggcttggtc     6240

ctaacaactc ctgggaaaaa gaagggatcg cggagcaaaa gcacagagtt ctacagcgag     6300

ctgtggttca tagtgttaat ggcgatgctg ggcttgatct tgttggccat ttttctgtcc     6360

ctgatactac aaagaaaaat ccacaaagag ccatatatca gagaaagacc tcccttggta     6420

cctcttcaga agaggatgtc tccattgaat gtttacccac cgggggaaaa ccatatgggg     6480

ttagccgata ccaaaattcc ccggtctggg acacctgtga gtatccgcag caaccggagt     6540

gcatgtgtcc tgcgcatccc gagtcaaaac caaaccagcc taacctactc ccagggttct     6600

cttcaccgca gcgtcagcca gctcatggac attcaagaca agaaagtctt gatggacaac     6660

tcactgtggg aagccatcat gggccacaac agtggactgt atgtggatga agaggacctg     6720

atgaacgcca tcaaggattt cagctcagtg actaaggaac gcaccacatt cacagacacc     6780

cacctg                                                                6786


<210>  41
<211>  1375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MiniUSH2A-2

<400>  41

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Pro 
        35                  40                  45              


Ser Arg Glu Val Thr Val Thr Thr Leu Ala Gly Leu Pro Glu Arg Gly 
    50                  55                  60                  


Ala Asn Leu Thr Ala Ser Val Leu Asn His Thr Ala Ile Asp Val Arg 
65                  70                  75                  80  


Trp Ala Lys Pro Thr Val Gln Asp Leu Gln Gly Glu Val Glu Tyr Tyr 
                85                  90                  95      


Thr Leu Phe Trp Ser Ser Ala Thr Ser Asn Asp Ser Leu Lys Ile Leu 
            100                 105                 110         


Pro Asp Val Asn Ser His Val Ile Gly His Leu Lys Pro Asn Thr Glu 
        115                 120                 125             


Tyr Trp Ile Phe Ile Ser Val Phe Asn Gly Val His Ser Ile Asn Ser 
    130                 135                 140                 


Ala Gly Leu His Ala Thr Thr Cys Asp Gly Glu Pro Gln Gly Met Leu 
145                 150                 155                 160 


Pro Pro Glu Val Val Ile Ile Asn Ser Thr Ala Val Arg Val Ile Trp 
                165                 170                 175     


Thr Ser Pro Ser Asn Pro Asn Gly Val Val Thr Glu Tyr Ser Ile Tyr 
            180                 185                 190         


Val Asn Asn Lys Leu Tyr Lys Thr Gly Met Asn Val Pro Gly Ser Phe 
        195                 200                 205             


Ile Leu Arg Asp Leu Ser Pro Phe Thr Ile Tyr Asp Ile Gln Val Glu 
    210                 215                 220                 


Val Cys Thr Ile Tyr Ala Cys Val Lys Ser Asn Gly Thr Gln Ile Thr 
225                 230                 235                 240 


Thr Val Glu Asp Thr Pro Ser Asp Ile Pro Thr Pro Thr Ile Arg Gly 
                245                 250                 255     


Ile Thr Ser Arg Ser Leu Gln Ile Asp Trp Val Ser Pro Arg Lys Pro 
            260                 265                 270         


Asn Gly Ile Ile Leu Gly Tyr Asp Leu Leu Trp Lys Thr Trp Tyr Pro 
        275                 280                 285             


Cys Ala Lys Thr Gln Lys Leu Val Gln Asp Gln Ser Asp Glu Leu Cys 
    290                 295                 300                 


Lys Ala Val Arg Cys Gln Lys Pro Glu Ser Ile Cys Gly His Ile Cys 
305                 310                 315                 320 


Tyr Ser Ser Glu Ala Lys Val Cys Cys Asn Gly Val Leu Tyr Asn Pro 
                325                 330                 335     


Lys Pro Gly His Arg Cys Cys Glu Glu Lys Tyr Ile Pro Phe Val Leu 
            340                 345                 350         


Asn Ser Thr Gly Val Cys Cys Gly Gly Arg Ile Gln Glu Ala Gln Pro 
        355                 360                 365             


Asn His Gln Cys Cys Ser Gly Tyr Tyr Ala Arg Ile Leu Pro Gly Glu 
    370                 375                 380                 


Val Cys Cys Pro Asp Glu Gln His Asn Arg Val Ser Val Gly Ile Gly 
385                 390                 395                 400 


Asp Ser Cys Cys Gly Arg Met Pro Tyr Ser Thr Ser Gly Asn Gln Ile 
                405                 410                 415     


Cys Cys Ala Gly Arg Leu His Asp Gly His Gly Gln Lys Cys Cys Gly 
            420                 425                 430         


Arg Gln Ile Val Ser Asn Asp Leu Glu Cys Cys Gly Gly Glu Glu Gly 
        435                 440                 445             


Val Val Tyr Asn Arg Leu Pro Gly Met Phe Cys Cys Gly Gln Asp Tyr 
    450                 455                 460                 


Val Asn Met Ser Asp Thr Ile Cys Cys Ser Ala Ser Ser Gly Glu Ser 
465                 470                 475                 480 


Lys Ala His Ile Lys Lys Asn Asp Pro Val Pro Val Lys Cys Cys Glu 
                485                 490                 495     


Thr Glu Leu Ile Pro Lys Ser Gln Lys Cys Cys Asn Gly Val Gly Tyr 
            500                 505                 510         


Asn Pro Leu Lys Tyr Val Cys Ser Asp Lys Ile Ser Thr Gly Met Met 
        515                 520                 525             


Met Lys Glu Thr Lys Glu Cys Arg Ile Leu Cys Pro Ala Ser Met Glu 
    530                 535                 540                 


Ala Thr Glu His Cys Gly Arg Cys Asp Phe Asn Phe Thr Ser His Ile 
545                 550                 555                 560 


Cys Thr Val Ile Arg Gly Ser His Asn Ser Thr Gly Lys Ala Ser Ile 
                565                 570                 575     


Glu Glu Met Cys Ser Ser Ala Glu Glu Thr Ile His Thr Gly Ser Val 
            580                 585                 590         


Asn Thr Tyr Ser Tyr Thr Asp Val Asn Leu Lys Pro Tyr Met Thr Tyr 
        595                 600                 605             


Glu Tyr Arg Ile Ser Ala Trp Asn Ser Tyr Gly Arg Gly Leu Ser Lys 
    610                 615                 620                 


Ala Val Arg Ala Arg Thr Lys Glu Asp Val Pro Gln Gly Val Ser Pro 
625                 630                 635                 640 


Pro Thr Trp Thr Lys Ile Asp Asn Leu Glu Asp Thr Ile Val Leu Asn 
                645                 650                 655     


Trp Arg Lys Pro Ile Gln Ser Asn Gly Pro Ile Ile Tyr Tyr Ile Leu 
            660                 665                 670         


Leu Arg Asn Gly Ile Glu Arg Phe Arg Gly Thr Ser Leu Ser Phe Ser 
        675                 680                 685             


Asp Lys Glu Gly Ile Gln Pro Phe Gln Glu Tyr Ser Tyr Gln Leu Lys 
    690                 695                 700                 


Ala Cys Thr Val Ala Gly Cys Ala Thr Ser Ser Lys Val Val Ala Ala 
705                 710                 715                 720 


Thr Thr Gln Gly Val Pro Glu Ser Ile Leu Pro Pro Ser Ile Thr Ala 
                725                 730                 735     


Leu Ser Ala Val Ala Leu His Leu Ser Trp Ser Val Pro Glu Lys Ser 
            740                 745                 750         


Asn Gly Val Ile Lys Glu Tyr Gln Ile Arg Gln Val Gly Lys Gly Leu 
        755                 760                 765             


Ile His Thr Asp Thr Thr Asp Arg Arg Gln His Thr Val Thr Gly Leu 
    770                 775                 780                 


Gln Pro Tyr Thr Asn Tyr Ser Phe Thr Leu Thr Ala Cys Thr Ser Ala 
785                 790                 795                 800 


Gly Cys Thr Ser Ser Glu Pro Phe Leu Gly Gln Thr Leu Gln Ala Ala 
                805                 810                 815     


Pro Glu Gly Val Trp Val Thr Pro Arg His Ile Ile Ile Asn Ser Thr 
            820                 825                 830         


Thr Val Glu Leu Tyr Trp Ser Leu Pro Glu Lys Pro Asn Gly Leu Val 
        835                 840                 845             


Ser Gln Tyr Gln Leu Ser Arg Asn Gly Asn Leu Leu Phe Leu Gly Gly 
    850                 855                 860                 


Ser Glu Glu Gln Asn Phe Thr Asp Lys Asn Leu Glu Pro Asn Ser Arg 
865                 870                 875                 880 


Tyr Thr Tyr Lys Leu Glu Val Lys Thr Gly Gly Gly Ser Ser Ala Ser 
                885                 890                 895     


Asp Asp Tyr Ile Val Gln Thr Pro Met Ser Thr Pro Glu Glu Ile Tyr 
            900                 905                 910         


Pro Pro Tyr Asn Ile Thr Val Ile Gly Pro Tyr Ser Ile Phe Val Ala 
        915                 920                 925             


Trp Ile Pro Pro Gly Ile Leu Ile Pro Glu Ile Pro Val Glu Tyr Asn 
    930                 935                 940                 


Val Leu Leu Asn Asp Gly Ser Val Thr Pro Leu Ala Phe Ser Val Gly 
945                 950                 955                 960 


His His Gln Ser Thr Leu Leu Glu Asn Leu Thr Pro Phe Thr Gln Tyr 
                965                 970                 975     


Glu Ile Arg Ile Gln Ala Cys Gln Asn Gly Ser Cys Gly Val Ser Ser 
            980                 985                 990         


Arg Met Phe Val Lys Thr Pro Glu  Ala Ala Pro Met Asp  Leu Asn Ser 
        995                 1000                 1005             


Pro Val  Leu Lys Ala Leu Gly  Ser Ala Cys Ile Glu  Ile Lys Trp 
    1010                 1015                 1020             


Met Pro  Pro Glu Lys Pro Asn  Gly Ile Ile Ile Asn  Tyr Phe Ile 
    1025                 1030                 1035             


Tyr Arg  Arg Pro Ala Gly Ile  Glu Glu Glu Ser Val  Leu Phe Val 
    1040                 1045                 1050             


Trp Ser  Glu Gly Ala Leu Glu  Phe Met Asp Glu Gly  Asp Thr Leu 
    1055                 1060                 1065             


Arg Pro  Phe Thr Leu Tyr Glu  Tyr Arg Val Arg Ala  Cys Asn Ser 
    1070                 1075                 1080             


Lys Gly  Ser Val Glu Ser Leu  Trp Ala Ser Glu Trp  Ile Ser Phe 
    1085                 1090                 1095             


Thr Thr  Gln Lys Glu Leu Pro  Gln Tyr Arg Ala Pro  Phe Ser Val 
    1100                 1105                 1110             


Asp Ser  Asn Leu Ser Val Val  Cys Val Asn Trp Ser  Asp Thr Phe 
    1115                 1120                 1125             


Leu Leu  Asn Gly Gln Leu Lys  Glu Tyr Val Leu Thr  Asp Gly Gly 
    1130                 1135                 1140             


Arg Arg  Val Tyr Ser Gly Leu  Asp Thr Thr Leu Tyr  Ile Pro Arg 
    1145                 1150                 1155             


Thr Ala  Asp Lys Thr Phe Phe  Phe Gln Val Ile Cys  Thr Thr Asp 
    1160                 1165                 1170             


Glu Gly  Ser Val Lys Thr Pro  Leu Ile Gln Tyr Asp  Thr Ser Thr 
    1175                 1180                 1185             


Gly Leu  Gly Leu Val Leu Thr  Thr Pro Gly Lys Lys  Lys Gly Ser 
    1190                 1195                 1200             


Arg Ser  Lys Ser Thr Glu Phe  Tyr Ser Glu Leu Trp  Phe Ile Val 
    1205                 1210                 1215             


Leu Met  Ala Met Leu Gly Leu  Ile Leu Leu Ala Ile  Phe Leu Ser 
    1220                 1225                 1230             


Leu Ile  Leu Gln Arg Lys Ile  His Lys Glu Pro Tyr  Ile Arg Glu 
    1235                 1240                 1245             


Arg Pro  Pro Leu Val Pro Leu  Gln Lys Arg Met Ser  Pro Leu Asn 
    1250                 1255                 1260             


Val Tyr  Pro Pro Gly Glu Asn  His Met Gly Leu Ala  Asp Thr Lys 
    1265                 1270                 1275             


Ile Pro  Arg Ser Gly Thr Pro  Val Ser Ile Arg Ser  Asn Arg Ser 
    1280                 1285                 1290             


Ala Cys  Val Leu Arg Ile Pro  Ser Gln Asn Gln Thr  Ser Leu Thr 
    1295                 1300                 1305             


Tyr Ser  Gln Gly Ser Leu His  Arg Ser Val Ser Gln  Leu Met Asp 
    1310                 1315                 1320             


Ile Gln  Asp Lys Lys Val Leu  Met Asp Asn Ser Leu  Trp Glu Ala 
    1325                 1330                 1335             


Ile Met  Gly His Asn Ser Gly  Leu Tyr Val Asp Glu  Glu Asp Leu 
    1340                 1345                 1350             


Met Asn  Ala Ile Lys Asp Phe  Ser Ser Val Thr Lys  Glu Arg Thr 
    1355                 1360                 1365             


Thr Phe  Thr Asp Thr His Leu  
    1370                 1375 


<210>  42
<211>  4125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiniUSH2A-2

<400>  42
atgaattgcc cagttctttc attgggctct ggcttcttgt ttcaggtcat tgaaatgttg       60

atctttgcct attttgcttc aatatccttg actgagtcac gaggtctttt cccaaggctg      120

gagaacgtgg gagctttcaa gccgagccga gaagtgactg tgacaacgtt agctggtctt      180

ccagagagag gagccaatct cactgcgagt gtccttaacc acacagccat cgacgtgagg      240

tgggctaaac caactgttca agacctacaa ggtgaagttg aatattacac acttttttgg      300

agttctgcta cctcaaacga ctctctaaaa atcttgccag atgtaaactc tcatgtcatt      360

ggccacctaa agccaaacac agagtattgg atctttatct ctgtcttcaa tggagtccac      420

agcatcaaca gtgcaggact tcatgcaacc acttgcgatg gggagcctca gggcatgctt      480

cctccagagg ttgtcatcat caacagtaca gctgtacgtg tcatctggac atctccttca      540

aacccaaatg gtgttgtcac tgagtattct atctatgtaa ataataagct ctacaagact      600

ggaatgaatg tgcctgggtc gtttattctg agagacctgt ctcccttcac tatctatgac      660

attcaggttg aagtctgcac aatatatgcc tgcgtgaaaa gcaatggaac ccaaattacc      720

actgtggaag acactccaag tgatatacca acacccacaa ttcgtggcat cacttcaaga      780

tctcttcaaa ttgattgggt gtctccacgg aagccaaatg gcatcattct tggatatgat      840

ctcctatgga aaacatggta tccatgcgct aaaactcaaa agttagtgca ggatcagagt      900

gatgagctct gcaaggcagt gaggtgtcaa aaacctgaat ctatctgtgg acacatttgc      960

tattcttctg aagctaaggt ttgttgtaac ggagtgctct ataaccccaa gcctggacat     1020

cgctgttgtg aagaaaagta tatcccgttt gttctgaatt ctactggagt ttgttgtggt     1080

ggccgaatac aggaggcaca accaaatcat cagtgctgct ctgggtatta cgctagaatt     1140

ctaccaggtg aagtatgctg tccagatgaa cagcacaatc gggtttctgt tggcattggt     1200

gattcctgct gtggcagaat gccgtactcc acctcaggaa accagatttg ctgtgctggg     1260

aggcttcatg atggccatgg ccagaagtgc tgtggcagac agattgtgag caacgattta     1320

gagtgttgtg gtggagaaga aggagtggtg tacaatcgcc ttccaggtat gttctgttgt     1380

gggcaggatt atgtgaatat gtcagatacc atatgctgct cagcttccag tggagagtct     1440

aaagcacata ttaaaaagaa tgacccggtg ccagtaaaat gctgtgagac tgaacttatt     1500

ccaaagagcc agaaatgctg taatggagtt ggatataatc ctttgaaata tgtttgctct     1560

gacaagattt caactggaat gatgatgaag gaaaccaaag agtgcaggat cctctgccca     1620

gcatctatgg aagccacaga acattgtggc aggtgtgact tcaactttac cagccacatt     1680

tgcactgtga taagagggtc tcacaattcc acagggaagg catcaattga agaaatgtgt     1740

tcatctgccg aagaaaccat tcatacaggg agtgtaaaca cgtactctta cacagatgtg     1800

aacctcaagc cctacatgac atatgagtac aggatttctg cctggaacag ctatgggcga     1860

ggactcagca aagctgtgag agccagaaca aaagaagatg tgcctcaagg agtgagtccc     1920

cctacgtgga ccaaaataga caatcttgaa gatacaattg tcttaaactg gagaaaacct     1980

atacaatcaa atggtcctat tatttactac atccttcttc gaaatggaat tgaacgtttt     2040

cggggaacat cactgagctt ctctgataaa gagggaattc aaccatttca ggaatattca     2100

tatcagctga aagcttgcac ggttgctggc tgtgccacca gtagcaaggt agttgcagct     2160

actacccaag gagttccgga gagcatcctg ccaccaagca tcacagccct aagtgcagtg     2220

gctctgcatc tgagctggag tgtccctgag aaatcaaacg gcgtcattaa agagtaccag     2280

atcaggcagg ttgggaaagg tctcatccac actgacacca ctgacaggag acagcatacg     2340

gtcacaggtc tccagccata caccaactac agcttcactc ttacagcttg tacatctgct     2400

gggtgcactt caagcgagcc ttttctaggt cagacactgc aggcagctcc tgaaggagtt     2460

tgggtgacac ctcgacacat tatcatcaat tctacaacag tggaattata ttggagtctg     2520

ccagaaaagc ccaatggcct cgtttctcaa tatcaattga gtcgtaatgg aaacttgctt     2580

ttcctgggtg gcagtgagga gcagaatttc actgataaaa acctggagcc caatagcaga     2640

tacacttaca agttagaagt caaaactgga ggtggcagca gtgctagtga tgattacatt     2700

gttcaaacac ctatgtcaac accagaagaa atctatcctc catataatat cacagtaatt     2760

gggccttatt ctatatttgt agcttggata ccaccaggga tcctcatccc cgaaattcct     2820

gtggagtaca atgtcttact caatgatgga agtgtaacac ctctggcctt ctccgttggt     2880

catcatcaat ccacccttct ggaaaatttg actccattca cacagtatga gataaggata     2940

caagcatgtc aaaatggaag ttgtggagtt agcagtagga tgtttgtcaa aacacctgaa     3000

gcagccccaa tggatcttaa ttctcctgtt cttaaggcac tggggtcagc ttgcatagag     3060

attaagtgga tgccacctga aaaaccaaat ggaatcatca tcaactactt tatttacaga     3120

cgccctgctg gcattgaaga ggagtctgtt ttatttgtct ggtcagaagg agcccttgaa     3180

tttatggatg aaggagacac cctgaggcct ttcacactct acgaatatcg ggtcagagcc     3240

tgtaactcca agggttcagt ggagagtctg tgggcttccg agtggatcag tttcaccacc     3300

caaaaagaat tgcctcagta ccgagcccca ttttcggtgg acagcaattt gtctgtggtg     3360

tgtgtgaact ggagtgacac cttcctcctg aacggccaac tgaaggagta cgtgttaacc     3420

gacggagggc gacgcgtgta cagcggcttg gacaccaccc tctacatacc gagaacggcg     3480

gacaaaacct tctttttcca ggtcatctgc acgactgacg aaggaagtgt taagacgccg     3540

ttgatccaat atgatacctc tactggactt ggcttggtcc taacaactcc tgggaaaaag     3600

aagggatcgc ggagcaaaag cacagagttc tacagcgagc tgtggttcat agtgttaatg     3660

gcgatgctgg gcttgatctt gttggccatt tttctgtccc tgatactaca aagaaaaatc     3720

cacaaagagc catatatcag agaaagacct cccttggtac ctcttcagaa gaggatgtct     3780

ccattgaatg tttacccacc gggggaaaac catatggggt tagccgatac caaaattccc     3840

cggtctggga cacctgtgag tatccgcagc aaccggagtg catgtgtcct gcgcatcccg     3900

agtcaaaacc aaaccagcct aacctactcc cagggttctc ttcaccgcag cgtcagccag     3960

ctcatggaca ttcaagacaa gaaagtcttg atggacaact cactgtggga agccatcatg     4020

ggccacaaca gtggactgta tgtggatgaa gaggacctga tgaacgccat caaggatttc     4080

agctcagtga ctaaggaacg caccacattc acagacaccc acctg                     4125


<210>  43
<211>  913
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MiniUSH2A-3

<400>  43

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Ser 
        35                  40                  45              


Ala Gly Leu His Ala Thr Thr Cys Asp Gly Glu Pro Gln Gly Met Leu 
    50                  55                  60                  


Pro Pro Glu Val Val Ile Ile Asn Ser Thr Ala Val Arg Val Ile Trp 
65                  70                  75                  80  


Thr Ser Pro Ser Asn Pro Asn Gly Val Val Thr Glu Tyr Ser Ile Tyr 
                85                  90                  95      


Val Asn Asn Lys Leu Tyr Lys Thr Gly Met Asn Val Pro Gly Ser Phe 
            100                 105                 110         


Ile Leu Arg Asp Leu Ser Pro Phe Thr Ile Tyr Asp Ile Gln Val Glu 
        115                 120                 125             


Val Cys Thr Ile Tyr Ala Cys Val Lys Ser Asn Gly Thr Gln Ile Thr 
    130                 135                 140                 


Thr Val Glu Asp Thr Pro Ser Asp Ile Pro Thr Pro Thr Ile Arg Gly 
145                 150                 155                 160 


Ile Thr Ser Arg Ser Leu Gln Ile Asp Trp Val Ser Pro Arg Lys Pro 
                165                 170                 175     


Asn Gly Ile Ile Leu Gly Tyr Asp Leu Leu Trp Lys Thr Trp Tyr Pro 
            180                 185                 190         


Cys Ala Lys Thr Gln Lys Leu Val Gln Asp Gln Ser Asp Glu Leu Cys 
        195                 200                 205             


Lys Ala Val Arg Cys Gln Lys Pro Glu Ser Ile Cys Gly His Ile Cys 
    210                 215                 220                 


Tyr Ser Ser Glu Ala Lys Val Cys Cys Asn Gly Val Leu Tyr Asn Pro 
225                 230                 235                 240 


Lys Pro Gly His Arg Cys Cys Glu Glu Lys Tyr Ile Pro Phe Val Leu 
                245                 250                 255     


Asn Ser Thr Gly Val Cys Cys Gly Gly Arg Ile Gln Glu Ala Gln Pro 
            260                 265                 270         


Asn His Gln Cys Cys Ser Gly Tyr Tyr Ala Arg Ile Leu Pro Gly Glu 
        275                 280                 285             


Val Cys Cys Pro Asp Glu Gln His Asn Arg Val Ser Val Gly Ile Gly 
    290                 295                 300                 


Asp Ser Cys Cys Gly Arg Met Pro Tyr Ser Thr Ser Gly Asn Gln Ile 
305                 310                 315                 320 


Cys Cys Ala Gly Arg Leu His Asp Gly His Gly Gln Lys Cys Cys Gly 
                325                 330                 335     


Arg Gln Ile Val Ser Asn Asp Leu Glu Cys Cys Gly Gly Glu Glu Gly 
            340                 345                 350         


Val Val Tyr Asn Arg Leu Pro Gly Met Phe Cys Cys Gly Gln Asp Tyr 
        355                 360                 365             


Val Asn Met Ser Asp Thr Ile Cys Cys Ser Ala Ser Ser Gly Glu Ser 
    370                 375                 380                 


Lys Ala His Ile Lys Lys Asn Asp Pro Val Pro Val Lys Cys Cys Glu 
385                 390                 395                 400 


Thr Glu Leu Ile Pro Lys Ser Gln Lys Cys Cys Asn Gly Val Gly Tyr 
                405                 410                 415     


Asn Pro Leu Lys Tyr Val Cys Ser Asp Lys Ile Ser Thr Gly Met Met 
            420                 425                 430         


Met Lys Glu Thr Lys Glu Cys Arg Ile Leu Cys Pro Ala Ser Met Glu 
        435                 440                 445             


Ala Thr Glu His Cys Gly Arg Cys Asp Phe Asn Phe Thr Ser His Ile 
    450                 455                 460                 


Cys Thr Val Ile Arg Gly Ser His Asn Ser Thr Gly Lys Ala Ser Ile 
465                 470                 475                 480 


Glu Glu Met Cys Ser Ser Ala Glu Glu Thr Ile His Thr Gly Ser Val 
                485                 490                 495     


Asn Thr Tyr Ser Tyr Thr Asp Val Asn Leu Lys Pro Tyr Met Thr Tyr 
            500                 505                 510         


Glu Tyr Arg Ile Ser Ala Trp Asn Ser Tyr Gly Arg Gly Leu Ser Lys 
        515                 520                 525             


Ala Val Arg Ala Arg Thr Lys Glu Asp Val Pro Gln Gly Val Ser Pro 
    530                 535                 540                 


Pro Thr Trp Thr Lys Ile Asp Asn Leu Glu Asp Thr Ile Val Leu Asn 
545                 550                 555                 560 


Trp Arg Lys Pro Ile Gln Ser Asn Gly Pro Ile Ile Tyr Tyr Ile Leu 
                565                 570                 575     


Leu Arg Asn Gly Ile Glu Arg Phe Arg Gly Thr Ser Leu Ser Phe Ser 
            580                 585                 590         


Asp Lys Glu Gly Ile Gln Pro Phe Gln Glu Tyr Ser Tyr Gln Leu Lys 
        595                 600                 605             


Ala Cys Thr Val Ala Gly Cys Ala Thr Ser Ser Lys Val Val Ala Ala 
    610                 615                 620                 


Thr Thr Gln Gly Val Ala Ser Glu Trp Ile Ser Phe Thr Thr Gln Lys 
625                 630                 635                 640 


Glu Leu Pro Gln Tyr Arg Ala Pro Phe Ser Val Asp Ser Asn Leu Ser 
                645                 650                 655     


Val Val Cys Val Asn Trp Ser Asp Thr Phe Leu Leu Asn Gly Gln Leu 
            660                 665                 670         


Lys Glu Tyr Val Leu Thr Asp Gly Gly Arg Arg Val Tyr Ser Gly Leu 
        675                 680                 685             


Asp Thr Thr Leu Tyr Ile Pro Arg Thr Ala Asp Lys Thr Phe Phe Phe 
    690                 695                 700                 


Gln Val Ile Cys Thr Thr Asp Glu Gly Ser Val Lys Thr Pro Leu Ile 
705                 710                 715                 720 


Gln Tyr Asp Thr Ser Thr Gly Leu Gly Leu Val Leu Thr Thr Pro Gly 
                725                 730                 735     


Lys Lys Lys Gly Ser Arg Ser Lys Ser Thr Glu Phe Tyr Ser Glu Leu 
            740                 745                 750         


Trp Phe Ile Val Leu Met Ala Met Leu Gly Leu Ile Leu Leu Ala Ile 
        755                 760                 765             


Phe Leu Ser Leu Ile Leu Gln Arg Lys Ile His Lys Glu Pro Tyr Ile 
    770                 775                 780                 


Arg Glu Arg Pro Pro Leu Val Pro Leu Gln Lys Arg Met Ser Pro Leu 
785                 790                 795                 800 


Asn Val Tyr Pro Pro Gly Glu Asn His Met Gly Leu Ala Asp Thr Lys 
                805                 810                 815     


Ile Pro Arg Ser Gly Thr Pro Val Ser Ile Arg Ser Asn Arg Ser Ala 
            820                 825                 830         


Cys Val Leu Arg Ile Pro Ser Gln Asn Gln Thr Ser Leu Thr Tyr Ser 
        835                 840                 845             


Gln Gly Ser Leu His Arg Ser Val Ser Gln Leu Met Asp Ile Gln Asp 
    850                 855                 860                 


Lys Lys Val Leu Met Asp Asn Ser Leu Trp Glu Ala Ile Met Gly His 
865                 870                 875                 880 


Asn Ser Gly Leu Tyr Val Asp Glu Glu Asp Leu Met Asn Ala Ile Lys 
                885                 890                 895     


Asp Phe Ser Ser Val Thr Lys Glu Arg Thr Thr Phe Thr Asp Thr His 
            900                 905                 910         


Leu 
    


<210>  44
<211>  2739
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiniUSH2A-3

<400>  44
atgaattgcc cagttctttc attgggctct ggcttcttgt ttcaggtcat tgaaatgttg       60

atctttgcct attttgcttc aatatccttg actgagtcac gaggtctttt cccaaggctg      120

gagaacgtgg gagctttcaa gagtgcagga cttcatgcaa ccacttgcga tggggagcct      180

cagggcatgc ttcctccaga ggttgtcatc atcaacagta cagctgtacg tgtcatctgg      240

acatctcctt caaacccaaa tggtgttgtc actgagtatt ctatctatgt aaataataag      300

ctctacaaga ctggaatgaa tgtgcctggg tcgtttattc tgagagacct gtctcccttc      360

actatctatg acattcaggt tgaagtctgc acaatatatg cctgcgtgaa aagcaatgga      420

acccaaatta ccactgtgga agacactcca agtgatatac caacacccac aattcgtggc      480

atcacttcaa gatctcttca aattgattgg gtgtctccac ggaagccaaa tggcatcatt      540

cttggatatg atctcctatg gaaaacatgg tatccatgcg ctaaaactca aaagttagtg      600

caggatcaga gtgatgagct ctgcaaggca gtgaggtgtc aaaaacctga atctatctgt      660

ggacacattt gctattcttc tgaagctaag gtttgttgta acggagtgct ctataacccc      720

aagcctggac atcgctgttg tgaagaaaag tatatcccgt ttgttctgaa ttctactgga      780

gtttgttgtg gtggccgaat acaggaggca caaccaaatc atcagtgctg ctctgggtat      840

tacgctagaa ttctaccagg tgaagtatgc tgtccagatg aacagcacaa tcgggtttct      900

gttggcattg gtgattcctg ctgtggcaga atgccgtact ccacctcagg aaaccagatt      960

tgctgtgctg ggaggcttca tgatggccat ggccagaagt gctgtggcag acagattgtg     1020

agcaacgatt tagagtgttg tggtggagaa gaaggagtgg tgtacaatcg ccttccaggt     1080

atgttctgtt gtgggcagga ttatgtgaat atgtcagata ccatatgctg ctcagcttcc     1140

agtggagagt ctaaagcaca tattaaaaag aatgacccgg tgccagtaaa atgctgtgag     1200

actgaactta ttccaaagag ccagaaatgc tgtaatggag ttggatataa tcctttgaaa     1260

tatgtttgct ctgacaagat ttcaactgga atgatgatga aggaaaccaa agagtgcagg     1320

atcctctgcc cagcatctat ggaagccaca gaacattgtg gcaggtgtga cttcaacttt     1380

accagccaca tttgcactgt gataagaggg tctcacaatt ccacagggaa ggcatcaatt     1440

gaagaaatgt gttcatctgc cgaagaaacc attcatacag ggagtgtaaa cacgtactct     1500

tacacagatg tgaacctcaa gccctacatg acatatgagt acaggatttc tgcctggaac     1560

agctatgggc gaggactcag caaagctgtg agagccagaa caaaagaaga tgtgcctcaa     1620

ggagtgagtc cccctacgtg gaccaaaata gacaatcttg aagatacaat tgtcttaaac     1680

tggagaaaac ctatacaatc aaatggtcct attatttact acatccttct tcgaaatgga     1740

attgaacgtt ttcggggaac atcactgagc ttctctgata aagagggaat tcaaccattt     1800

caggaatatt catatcagct gaaagcttgc acggttgctg gctgtgccac cagtagcaag     1860

gtagttgcag ctactaccca aggagttgct tccgagtgga tcagtttcac cacccaaaaa     1920

gaattgcctc agtaccgagc cccattttcg gtggacagca atttgtctgt ggtgtgtgtg     1980

aactggagtg acaccttcct cctgaacggc caactgaagg agtacgtgtt aaccgacgga     2040

gggcgacgcg tgtacagcgg cttggacacc accctctaca taccgagaac ggcggacaaa     2100

accttctttt tccaggtcat ctgcacgact gacgaaggaa gtgttaagac gccgttgatc     2160

caatatgata cctctactgg acttggcttg gtcctaacaa ctcctgggaa aaagaaggga     2220

tcgcggagca aaagcacaga gttctacagc gagctgtggt tcatagtgtt aatggcgatg     2280

ctgggcttga tcttgttggc catttttctg tccctgatac tacaaagaaa aatccacaaa     2340

gagccatata tcagagaaag acctcccttg gtacctcttc agaagaggat gtctccattg     2400

aatgtttacc caccggggga aaaccatatg gggttagccg ataccaaaat tccccggtct     2460

gggacacctg tgagtatccg cagcaaccgg agtgcatgtg tcctgcgcat cccgagtcaa     2520

aaccaaacca gcctaaccta ctcccagggt tctcttcacc gcagcgtcag ccagctcatg     2580

gacattcaag acaagaaagt cttgatggac aactcactgt gggaagccat catgggccac     2640

aacagtggac tgtatgtgga tgaagaggac ctgatgaacg ccatcaagga tttcagctca     2700

gtgactaagg aacgcaccac attcacagac acccacctg                            2739


<210>  45
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MiniUSH2A-4

<400>  45

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Ser 
        35                  40                  45              


Lys Gly Pro Thr Ala Glu Leu Arg Thr His Pro Ala Pro Pro Ser Gly 
    50                  55                  60                  


Leu Ser Ser Pro Gln Ile Gly Thr Leu Ala Ser Arg Thr Ala Ser Phe 
65                  70                  75                  80  


Arg Trp Ser Pro Pro Met Phe Pro Asn Gly Val Ile His Ser Tyr Glu 
                85                  90                  95      


Leu Gln Phe His Val Ala Cys Pro Pro Asp Ser Ala Leu Pro Cys Thr 
            100                 105                 110         


Pro Ser Gln Ile Glu Thr Lys Tyr Thr Gly Leu Gly Gln Lys Ala Ser 
        115                 120                 125             


Leu Gly Gly Leu Gln Pro Tyr Thr Thr Tyr Lys Leu Arg Val Val Ala 
    130                 135                 140                 


His Asn Glu Val Gly Ser Thr Ala Ser Glu Trp Ile Ser Phe Thr Thr 
145                 150                 155                 160 


Gln Lys Glu Leu Pro Gln Tyr Arg Ala Pro Phe Ser Val Asp Ser Asn 
                165                 170                 175     


Leu Ser Val Val Cys Val Asn Trp Ser Asp Thr Phe Leu Leu Asn Gly 
            180                 185                 190         


Gln Leu Lys Glu Tyr Val Leu Thr Asp Gly Gly Arg Arg Val Tyr Ser 
        195                 200                 205             


Gly Leu Asp Thr Thr Leu Tyr Ile Pro Arg Thr Ala Asp Lys Thr Phe 
    210                 215                 220                 


Phe Phe Gln Val Ile Cys Thr Thr Asp Glu Gly Ser Val Lys Thr Pro 
225                 230                 235                 240 


Leu Ile Gln Tyr Asp Thr Ser Thr Gly Leu Gly Leu Val Leu Thr Thr 
                245                 250                 255     


Pro Gly Lys Lys Lys Gly Ser Arg Ser Lys Ser Thr Glu Phe Tyr Ser 
            260                 265                 270         


Glu Leu Trp Phe Ile Val Leu Met Ala Met Leu Gly Leu Ile Leu Leu 
        275                 280                 285             


Ala Ile Phe Leu Ser Leu Ile Leu Gln Arg Lys Ile His Lys Glu Pro 
    290                 295                 300                 


Tyr Ile Arg Glu Arg Pro Pro Leu Val Pro Leu Gln Lys Arg Met Ser 
305                 310                 315                 320 


Pro Leu Asn Val Tyr Pro Pro Gly Glu Asn His Met Gly Leu Ala Asp 
                325                 330                 335     


Thr Lys Ile Pro Arg Ser Gly Thr Pro Val Ser Ile Arg Ser Asn Arg 
            340                 345                 350         


Ser Ala Cys Val Leu Arg Ile Pro Ser Gln Asn Gln Thr Ser Leu Thr 
        355                 360                 365             


Tyr Ser Gln Gly Ser Leu His Arg Ser Val Ser Gln Leu Met Asp Ile 
    370                 375                 380                 


Gln Asp Lys Lys Val Leu Met Asp Asn Ser Leu Trp Glu Ala Ile Met 
385                 390                 395                 400 


Gly His Asn Ser Gly Leu Tyr Val Asp Glu Glu Asp Leu Met Asn Ala 
                405                 410                 415     


Ile Lys Asp Phe Ser Ser Val Thr Lys Glu Arg Thr Thr Phe Thr Asp 
            420                 425                 430         


Thr His Leu 
        435 


<210>  46
<211>  1305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiniUSH2A-4

<400>  46
atgaattgcc cagttctttc attgggctct ggcttcttgt ttcaggtcat tgaaatgttg       60

atctttgcct attttgcttc aatatccttg actgagtcac gaggtctttt cccaaggctg      120

gagaacgtgg gagctttcaa gagcaaagga ccgacagctg aactgagaac ccatcctgcc      180

ccaccctcag gactgtcctc tccacaaatc gggacgctgg cctcaaggac ggcctccttc      240

cggtggagtc cccccatgtt ccccaatggt gtcattcaca gctatgaact ccaattccac      300

gtggcttgcc ctcctgactc agccctcccc tgtactccca gccaaataga aacaaagtac      360

acggggctgg ggcagaaagc cagccttggg ggtctccagc cctacaccac atacaagctg      420

agagtggtgg cacacaacga ggtgggcagt acggcttccg agtggatcag tttcaccacc      480

caaaaagaat tgcctcagta ccgagcccca ttttcggtgg acagcaattt gtctgtggtg      540

tgtgtgaact ggagtgacac cttcctcctg aacggccaac tgaaggagta cgtgttaacc      600

gacggagggc gacgcgtgta cagcggcttg gacaccaccc tctacatacc gagaacggcg      660

gacaaaacct tctttttcca ggtcatctgc acgactgacg aaggaagtgt taagacgccg      720

ttgatccaat atgatacctc tactggactt ggcttggtcc taacaactcc tgggaaaaag      780

aagggatcgc ggagcaaaag cacagagttc tacagcgagc tgtggttcat agtgttaatg      840

gcgatgctgg gcttgatctt gttggccatt tttctgtccc tgatactaca aagaaaaatc      900

cacaaagagc catatatcag agaaagacct cccttggtac ctcttcagaa gaggatgtct      960

ccattgaatg tttacccacc gggggaaaac catatggggt tagccgatac caaaattccc     1020

cggtctggga cacctgtgag tatccgcagc aaccggagtg catgtgtcct gcgcatcccg     1080

agtcaaaacc aaaccagcct aacctactcc cagggttctc ttcaccgcag cgtcagccag     1140

ctcatggaca ttcaagacaa gaaagtcttg atggacaact cactgtggga agccatcatg     1200

ggccacaaca gtggactgta tgtggatgaa gaggacctga tgaacgccat caaggatttc     1260

agctcagtga ctaaggaacg caccacattc acagacaccc acctg                     1305


<210>  47
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MiniUSH2A-5

<400>  47

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Ala 
        35                  40                  45              


Ser Glu Trp Ile Ser Phe Thr Thr Gln Lys Glu Leu Pro Gln Tyr Arg 
    50                  55                  60                  


Ala Pro Phe Ser Val Asp Ser Asn Leu Ser Val Val Cys Val Asn Trp 
65                  70                  75                  80  


Ser Asp Thr Phe Leu Leu Asn Gly Gln Leu Lys Glu Tyr Val Leu Thr 
                85                  90                  95      


Asp Gly Gly Arg Arg Val Tyr Ser Gly Leu Asp Thr Thr Leu Tyr Ile 
            100                 105                 110         


Pro Arg Thr Ala Asp Lys Thr Phe Phe Phe Gln Val Ile Cys Thr Thr 
        115                 120                 125             


Asp Glu Gly Ser Val Lys Thr Pro Leu Ile Gln Tyr Asp Thr Ser Thr 
    130                 135                 140                 


Gly Leu Gly Leu Val Leu Thr Thr Pro Gly Lys Lys Lys Gly Ser Arg 
145                 150                 155                 160 


Ser Lys Ser Thr Glu Phe Tyr Ser Glu Leu Trp Phe Ile Val Leu Met 
                165                 170                 175     


Ala Met Leu Gly Leu Ile Leu Leu Ala Ile Phe Leu Ser Leu Ile Leu 
            180                 185                 190         


Gln Arg Lys Ile His Lys Glu Pro Tyr Ile Arg Glu Arg Pro Pro Leu 
        195                 200                 205             


Val Pro Leu Gln Lys Arg Met Ser Pro Leu Asn Val Tyr Pro Pro Gly 
    210                 215                 220                 


Glu Asn His Met Gly Leu Ala Asp Thr Lys Ile Pro Arg Ser Gly Thr 
225                 230                 235                 240 


Pro Val Ser Ile Arg Ser Asn Arg Ser Ala Cys Val Leu Arg Ile Pro 
                245                 250                 255     


Ser Gln Asn Gln Thr Ser Leu Thr Tyr Ser Gln Gly Ser Leu His Arg 
            260                 265                 270         


Ser Val Ser Gln Leu Met Asp Ile Gln Asp Lys Lys Val Leu Met Asp 
        275                 280                 285             


Asn Ser Leu Trp Glu Ala Ile Met Gly His Asn Ser Gly Leu Tyr Val 
    290                 295                 300                 


Asp Glu Glu Asp Leu Met Asn Ala Ile Lys Asp Phe Ser Ser Val Thr 
305                 310                 315                 320 


Lys Glu Arg Thr Thr Phe Thr Asp Thr His Leu 
                325                 330     


<210>  48
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiniUSH2A-5

<400>  48
atgaattgcc cagttctttc attgggctct ggcttcttgt ttcaggtcat tgaaatgttg       60

atctttgcct attttgcttc aatatccttg actgagtcac gaggtctttt cccaaggctg      120

gagaacgtgg gagctttcaa ggcttccgag tggatcagtt tcaccaccca aaaagaattg      180

cctcagtacc gagccccatt ttcggtggac agcaatttgt ctgtggtgtg tgtgaactgg      240

agtgacacct tcctcctgaa cggccaactg aaggagtacg tgttaaccga cggagggcga      300

cgcgtgtaca gcggcttgga caccaccctc tacataccga gaacggcgga caaaaccttc      360

tttttccagg tcatctgcac gactgacgaa ggaagtgtta agacgccgtt gatccaatat      420

gatacctcta ctggacttgg cttggtccta acaactcctg ggaaaaagaa gggatcgcgg      480

agcaaaagca cagagttcta cagcgagctg tggttcatag tgttaatggc gatgctgggc      540

ttgatcttgt tggccatttt tctgtccctg atactacaaa gaaaaatcca caaagagcca      600

tatatcagag aaagacctcc cttggtacct cttcagaaga ggatgtctcc attgaatgtt      660

tacccaccgg gggaaaacca tatggggtta gccgatacca aaattccccg gtctgggaca      720

cctgtgagta tccgcagcaa ccggagtgca tgtgtcctgc gcatcccgag tcaaaaccaa      780

accagcctaa cctactccca gggttctctt caccgcagcg tcagccagct catggacatt      840

caagacaaga aagtcttgat ggacaactca ctgtgggaag ccatcatggg ccacaacagt      900

ggactgtatg tggatgaaga ggacctgatg aacgccatca aggatttcag ctcagtgact      960

aaggaacgca ccacattcac agacacccac ctg                                   993


<210>  49
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  49
aattcgagct cggtacatga attgcccagt tct                                    33


<210>  50
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  50
cggctcggct tgaaagctcc cacg                                              24


<210>  51
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  51
ctttcaagcc gagccgagaa gtg                                               23


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  52
tcggaagccc acagactctc cac                                               23


<210>  53
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  53
gtctgtgggc ttccgagtgg atc                                               23


<210>  54
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  54
gccaagcttg catgccttac aggtgggtgt ct                                     32


<210>  55
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  55
ggggacaagt ttgtacaaaa aagcaggctt cgccgccgcc atgaattgcc cagttctttc       60


<210>  56
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  56
ggggaccact ttgtacaaga aagctgggtc ttacaggtgg gtgtctgt                    48


<210>  57
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  57
aattcgagct cggtacatga attgcccagt tct                                    33


<210>  58
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  58
ggattgtaac atccaacatc attaaagc                                          28


<210>  59
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  59
ttggatgtta caatccgtca gctattt                                           27


<210>  60
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  60
cggctcggac cccgtgtaaa tttaac                                            26


<210>  61
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  61
cacggggtcc gagccgagaa gtg                                               23


<210>  62
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  62
gccaagcttg catgccttac aggtgggtgt ct                                     32


<210>  63
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  63
ggggacaagt ttgtacaaaa aagcaggctt cgccgccgcc atgaattgcc cagttctttc       60


<210>  64
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  64
ggggaccact ttgtacaaga aagctgggtc ttacaggtgg gtgtctgt                    48


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  65
agacactctg cagtattcac                                                   20


<210>  66
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  66
cagaactgaa tactttcagc                                                   20


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  67
gagtcgtttg aggtagcaga                                                   20


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  68
tgcctcgttt cttcacagtc                                                   20


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  69
gagcccaatg aaagaactgg                                                   20


<210>  70
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  70
gtcgtcccgt cacatttatt ac                                                22


<210>  71
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  71
atcatgcagt cctactctga cac                                               23


<210>  72
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide fragment

<400>  72

Pro Ala Pro Pro Ser Gly Leu Ser Ser Pro Gln Ile Gly Thr Leu Ala 
1               5                   10                  15      


Ser Arg Thr Ala Ser Phe Arg Trp Ser Pro Pro Met Phe Pro Asn Gly 
            20                  25                  30          


Val Ile His Ser Tyr Glu Leu Gln Phe His Val Ala Cys Pro Pro Asp 
        35                  40                  45              


Ser Ala Leu Pro Cys Thr Pro Ser Gln Ile Glu Thr Lys Tyr Thr Gly 
    50                  55                  60                  


Leu Gly Gln Lys Ala Ser Leu Gly Gly Leu Gln Pro Tyr Thr Thr Tyr 
65                  70                  75                  80  


Lys Leu Arg Val Val Ala His Asn Glu Val Gly Ser Thr 
                85                  90              


<210>  73
<211>  279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide fragment

<400>  73
cctgccccac cctcaggact gtcctctcca caaatcggga cgctggcctc aaggacggcc       60

tccttccggt ggagtccccc catgttcccc aatggtgtca ttcacagcta tgaactccaa      120

ttccacgtgg cttgccctcc tgactcagcc ctcccctgta ctcccagcca aatagaaaca      180

aagtacacgg ggctggggca gaaagccagc cttgggggtc tccagcccta caccacatac      240

aagctgagag tggtggcaca caacgaggtg ggcagtacg                             279


<210>  74
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MiniUSH2A-6

<400>  74

Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Ser 
        35                  40                  45              


Lys Gly Pro Thr Ala Glu Leu Arg Thr His Pro Ala Pro Pro Ser Gly 
    50                  55                  60                  


Leu Ser Ser Pro Gln Ile Gly Thr Leu Ala Ser Arg Thr Ala Ser Phe 
65                  70                  75                  80  


Arg Trp Ser Pro Pro Met Phe Pro Asn Gly Val Ile His Ser Tyr Glu 
                85                  90                  95      


Leu Gln Phe His Val Ala Cys Pro Pro Asp Ser Ala Leu Pro Cys Thr 
            100                 105                 110         


Pro Ser Gln Ile Glu Thr Lys Tyr Thr Gly Leu Gly Gln Lys Ala Ser 
        115                 120                 125             


Leu Gly Gly Leu Gln Pro Tyr Thr Thr Tyr Lys Leu Arg Val Val Ala 
    130                 135                 140                 


His Asn Glu Val Gly Ser Thr Ala Ser Glu Trp Ile Ser Phe Thr Thr 
145                 150                 155                 160 


Gln Lys Glu Leu Pro Gln Tyr Arg Ala Pro Phe Ser Val Asp Ser Asn 
                165                 170                 175     


Leu Ser Val Val Cys Val Asn Trp Ser Asp Thr Phe Leu Leu Asn Gly 
            180                 185                 190         


Gln Leu Lys Glu Tyr Val Leu Thr Asp Gly Gly Arg Arg Val Tyr Ser 
        195                 200                 205             


Gly Leu Asp Thr Thr Leu Tyr Ile Pro Arg Thr Ala Asp Lys Thr Phe 
    210                 215                 220                 


Phe Phe Gln Val Ile Cys Thr Thr Asp Glu Gly Ser Val Lys Thr Pro 
225                 230                 235                 240 


Leu Ile Gln Tyr Asp Thr Ser Thr Gly Leu Gly Leu Val Leu Thr Thr 
                245                 250                 255     


Pro Gly Lys Lys Lys Gly Ser Arg Ser Lys Ser Thr Glu Phe Tyr Ser 
            260                 265                 270         


Glu Leu Trp Phe Ile Val Leu Met Ala Met Leu Gly Leu Ile Leu Leu 
        275                 280                 285             


Ala Ile Phe Leu Ser Leu Ile Leu Gln Arg Lys Ile His Lys Glu Pro 
    290                 295                 300                 


Tyr Ile Arg Glu Arg Pro Pro Leu Val Pro Leu Gln Lys Arg Met Ser 
305                 310                 315                 320 


Pro Leu Asn Val Tyr Pro Pro Gly Glu Asn His Met Gly Leu Ala Asp 
                325                 330                 335     


Thr Lys Ile Pro Arg Ser Gly Thr Pro Val Ser Ile Arg Ser Asn Arg 
            340                 345                 350         


Ser Ala Cys Val Leu Arg Ile Pro Ser Gln Asn Gln Thr Ser Leu Thr 
        355                 360                 365             


Tyr Ser Gln Gly Ser Leu His Arg Ser Val Ser Gln Leu Met Asp Ile 
    370                 375                 380                 


Gln Asp Lys Lys Val Leu Met Asp Asn Ser Leu Trp Glu Ala Ile Met 
385                 390                 395                 400 


Gly His Asn Ser Gly Leu Tyr Val Asp Glu Glu Asp Leu Met Asn Ala 
                405                 410                 415     


Ile Lys Asp Phe Ser Ser Val Thr Lys Glu Arg Thr Thr Phe Thr Asp 
            420                 425                 430         


Thr His Leu 
        435 


<210>  75
<211>  1308
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MiniUSH2A-6

<400>  75
atgaattgcc cagttctttc attgggctct ggcttcttgt ttcaggtcat tgaaatgttg       60

atctttgcct attttgcttc aatatccttg actgagtcac gaggtctttt cccaaggctg      120

gagaacgtgg gagctttcaa gagcaaagga ccgacagctg aactgagaac ccatcctgcc      180

ccaccctcag gactgtcctc tccacaaatc gggacgctgg cctcaaggac ggcctccttc      240

cggtggagtc cccccatgtt ccccaatggt gtcattcaca gctatgaact ccaattccac      300

gtggcttgcc ctcctgactc agccctcccc tgtactccca gccaaataga aacaaagtac      360

acggggctgg ggcagaaagc cagccttggg ggtctccagc cctacaccac atacaagctg      420

agagtggtgg cacacaacga ggtgggcagt acggcttccg agtggatcag tttcaccacc      480

caaaaagaat tgcctcagta ccgagcccca ttttcggtgg acagcaattt gtctgtggtg      540

tgtgtgaact ggagtgacac cttcctcctg aacggccaac tgaaggagta cgtgttaacc      600

gacggagggc gacgcgtgta cagcggcttg gacaccaccc tctacatacc gagaacggcg      660

gacaaaacct tctttttcca ggtcatctgc acgactgacg aaggaagtgt taagacgccg      720

ttgatccaat atgatacctc tactggactt ggcttggtcc taacaactcc tgggaaaaag      780

aagggatcgc ggagcaaaag cacagagttc tacagcgagc tgtggttcat agtgttaatg      840

gcgatgctgg gcttgatctt gttggccatt tttctgtccc tgatactaca aagaaaaatc      900

cacaaagagc catatatcag agaaagacct cccttggtac ctcttcagaa gaggatgtct      960

ccattgaatg tttacccacc gggggaaaac catatggggt tagccgatac caaaattccc     1020

cggtctggga cacctgtgag tatccgcagc aaccggagtg catgtgtcct gcgcatcccg     1080

agtcaaaacc aaaccagcct aacctactcc cagggttctc ttcaccgcag cgtcagccag     1140

ctcatggaca ttcaagacaa gaaagtcttg atggacaact cactgtggga agccatcatg     1200

ggccacaaca gtggactgta tgtggatgaa gaggacctga tgaacgccat caaggatttc     1260

agctcagtga ctaaggaacg caccacattc acagacaccc acctgtaa                  1308


<210>  76
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  76
aattcgagct cggtacatga attgcccagt tct                                    33


<210>  77
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  77
cctttgctct tgaaagctcc cacg                                              24


<210>  78
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  78
ctttcaagag caaaggaccg aca                                               23


<210>  79
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  79
gccaagcttg catgccttac aggtgggtgt ct                                     32


<210>  80
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  80
ggggacaagt ttgtacaaaa aagcaggctt cgccgccgcc atgaattgcc cagttctttc       60


<210>  81
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  81
ggggaccact ttgtacaaga aagctgggtc ttacaggtgg gtgtctgt                    48


<210>  82
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  82
aattcgagct cggtacatga attgcccagt tct                                    33


<210>  83
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  83
tcggaagcct tgaaagctcc cacg                                              24


<210>  84
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  84
ctttcaaggc ttccgagtgg atc                                               23


<210>  85
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  85
gccaagcttg catgccttac aggtgggtgt ct                                     32


<210>  86
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  86
ggggacaagt ttgtacaaaa aagcaggctt cgccgccgcc atgaattgcc cagttctttc       60


<210>  87
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  87
ggggaccact ttgtacaaga aagctgggtc ttacaggtgg gtgtctgt                    48


