                               SEQUENCE LISTING

<110> BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
 
<120> COMPOSITIONS AND METHODS FOR TREATING CANCER

<130> 167688.011601/PCT

<140> PCT/US2019/020101
<141> 2019-02-28

<150> 62/637,334
<151> 2018-03-01

<160> 6     

<170> PatentIn version 3.5

<210> 1
<211> 403
<212> PRT
<213> Homo sapiens

<400> 1
Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


<210> 2
<211> 8718
<212> DNA
<213> Homo sapiens

<400> 2
cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc       60

ttccgaggcg cccgggctcc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggt      120

gatgtggcgg gactctttat gcgctgcggc aggatacgcg ctcggcgctg ggacgcgact      180

gcgctcagtt ctctcctctc ggaagctgca gccatgatgg aagtttgaga gttgagccgc      240

tgtgaggcga ggccgggctc aggcgaggga gatgagagac ggcggcggcc gcggcccgga      300

gcccctctca gcgcctgtga gcagccgcgg gggcagcgcc ctcggggagc cggccggcct      360

gcggcggcgg cagcggcggc gtttctcgcc tcctcttcgt cttttctaac cgtgcagcct      420

cttcctcggc ttctcctgaa agggaaggtg gaagccgtgg gctcgggcgg gagccggctg      480

aggcgcggcg gcggcggcgg cacctcccgc tcctggagcg ggggggagaa gcggcggcgg      540

cggcggccgc ggcggctgca gctccaggga gggggtctga gtcgcctgtc accatttcca      600

gggctgggaa cgccggagag ttggtctctc cccttctact gcctccaaca cggcggcggc      660

ggcggcggca catccaggga cccgggccgg ttttaaacct cccgtccgcc gccgccgcac      720

cccccgtggc ccgggctccg gaggccgccg gcggaggcag ccgttcggag gattattcgt      780

cttctcccca ttccgctgcc gccgctgcca ggcctctggc tgctgaggag aagcaggccc      840

agtcgctgca accatccagc agccgccgca gcagccatta cccggctgcg gtccagagcc      900

aagcggcggc agagcgaggg gcatcagcta ccgccaagtc cagagccatt tccatcctgc      960

agaagaagcc ccgccaccag cagcttctgc catctctctc ctcctttttc ttcagccaca     1020

ggctcccaga catgacagcc atcatcaaag agatcgttag cagaaacaaa aggagatatc     1080

aagaggatgg attcgactta gacttgacct atatttatcc aaacattatt gctatgggat     1140

ttcctgcaga aagacttgaa ggcgtataca ggaacaatat tgatgatgta gtaaggtttt     1200

tggattcaaa gcataaaaac cattacaaga tatacaatct ttgtgctgaa agacattatg     1260

acaccgccaa atttaattgc agagttgcac aatatccttt tgaagaccat aacccaccac     1320

agctagaact tatcaaaccc ttttgtgaag atcttgacca atggctaagt gaagatgaca     1380

atcatgttgc agcaattcac tgtaaagctg gaaagggacg aactggtgta atgatatgtg     1440

catatttatt acatcggggc aaatttttaa aggcacaaga ggccctagat ttctatgggg     1500

aagtaaggac cagagacaaa aagggagtaa ctattcccag tcagaggcgc tatgtgtatt     1560

attatagcta cctgttaaag aatcatctgg attatagacc agtggcactg ttgtttcaca     1620

agatgatgtt tgaaactatt ccaatgttca gtggcggaac ttgcaatcct cagtttgtgg     1680

tctgccagct aaaggtgaag atatattcct ccaattcagg acccacacga cgggaagaca     1740

agttcatgta ctttgagttc cctcagccgt tacctgtgtg tggtgatatc aaagtagagt     1800

tcttccacaa acagaacaag atgctaaaaa aggacaaaat gtttcacttt tgggtaaata     1860

cattcttcat accaggacca gaggaaacct cagaaaaagt agaaaatgga agtctatgtg     1920

atcaagaaat cgatagcatt tgcagtatag agcgtgcaga taatgacaag gaatatctag     1980

tacttacttt aacaaaaaat gatcttgaca aagcaaataa agacaaagcc aaccgatact     2040

tttctccaaa ttttaaggtg aagctgtact tcacaaaaac agtagaggag ccgtcaaatc     2100

cagaggctag cagttcaact tctgtaacac cagatgttag tgacaatgaa cctgatcatt     2160

atagatattc tgacaccact gactctgatc cagagaatga accttttgat gaagatcagc     2220

atacacaaat tacaaaagtc tgaatttttt tttatcaaga gggataaaac accatgaaaa     2280

taaacttgaa taaactgaaa atggaccttt ttttttttaa tggcaatagg acattgtgtc     2340

agattaccag ttataggaac aattctcttt tcctgaccaa tcttgtttta ccctatacat     2400

ccacagggtt ttgacacttg ttgtccagtt gaaaaaaggt tgtgtagctg tgtcatgtat     2460

ataccttttt gtgtcaaaag gacatttaaa attcaattag gattaataaa gatggcactt     2520

tcccgtttta ttccagtttt ataaaaagtg gagacagact gatgtgtata cgtaggaatt     2580

ttttcctttt gtgttctgtc accaactgaa gtggctaaag agctttgtga tatactggtt     2640

cacatcctac ccctttgcac ttgtggcaac agataagttt gcagttggct aagagaggtt     2700

tccgaagggt tttgctacat tctaatgcat gtattcgggt taggggaatg gagggaatgc     2760

tcagaaagga aataatttta tgctggactc tggaccatat accatctcca gctatttaca     2820

cacacctttc tttagcatgc tacagttatt aatctggaca ttcgaggaat tggccgctgt     2880

cactgcttgt tgtttgcgca ttttttttta aagcatattg gtgctagaaa aggcagctaa     2940

aggaagtgaa tctgtattgg ggtacaggaa tgaaccttct gcaacatctt aagatccaca     3000

aatgaaggga tataaaaata atgtcatagg taagaaacac agcaacaatg acttaaccat     3060

ataaatgtgg aggctatcaa caaagaatgg gcttgaaaca ttataaaaat tgacaatgat     3120

ttattaaata tgttttctca attgtaacga cttctccatc tcctgtgtaa tcaaggccag     3180

tgctaaaatt cagatgctgt tagtacctac atcagtcaac aacttacact tattttacta     3240

gttttcaatc ataatacctg ctgtggatgc ttcatgtgct gcctgcaagc ttcttttttc     3300

tcattaaata taaaatattt tgtaatgctg cacagaaatt ttcaatttga gattctacag     3360

taagcgtttt ttttctttga agatttatga tgcacttatt caatagctgt cagccgttcc     3420

acccttttga ccttacacat tctattacaa tgaattttgc agttttgcac attttttaaa     3480

tgtcattaac tgttagggaa ttttacttga atactgaata catataatgt ttatattaaa     3540

aaggacattt gtgttaaaaa ggaaattaga gttgcagtaa actttcaatg ctgcacacaa     3600

aaaaaagaca tttgattttt cagtagaaat tgtcctacat gtgctttatt gatttgctat     3660

tgaaagaata gggttttttt tttttttttt tttttttttt ttaaatgtgc agtgttgaat     3720

catttcttca tagtgctccc ccgagttggg actagggctt caatttcact tcttaaaaaa     3780

aatcatcata tatttgatat gcccagactg catacgattt taagcggagt acaactacta     3840

ttgtaaagct aatgtgaaga tattattaaa aaggtttttt tttccagaaa tttggtgtct     3900

tcaaattata ccttcacctt gacatttgaa tatccagcca ttttgtttct taatggtata     3960

aaattccatt ttcaataact tattggtgct gaaattgttc actagctgtg gtctgaccta     4020

gttaatttac aaatacagat tgaataggac ctactagagc agcatttata gagtttgatg     4080

gcaaatagat taggcagaac ttcatctaaa atattcttag taaataatgt tgacacgttt     4140

tccatacctt gtcagtttca ttcaacaatt tttaaatttt taacaaagct cttaggattt     4200

acacatttat atttaaacat tgatatatag agtattgatt gattgctcat aagttaaatt     4260

ggtaaagtta gagacaacta ttctaacacc tcaccattga aatttatatg ccaccttgtc     4320

tttcataaaa gctgaaaatt gttacctaaa atgaaaatca acttcatgtt ttgaagatag     4380

ttataaatat tgttctttgt tacaatttcg ggcaccgcat attaaaacgt aactttattg     4440

ttccaatatg taacatggag ggccaggtca taaataatga cattataatg ggcttttgca     4500

ctgttattat ttttcctttg gaatgtgaag gtctgaatga gggttttgat tttgaatgtt     4560

tcaatgtttt tgagaagcct tgcttacatt ttatggtgta gtcattggaa atggaaaaat     4620

ggcattatat atattatata tataaatata tattatacat actctcctta ctttatttca     4680

gttaccatcc ccatagaatt tgacaagaat tgctatgact gaaaggtttt cgagtcctaa     4740

ttaaaacttt atttatggca gtattcataa ttagcctgaa atgcattctg taggtaatct     4800

ctgagtttct ggaatatttt cttagacttt ttggatgtgc agcagcttac atgtctgaag     4860

ttacttgaag gcatcacttt taagaaagct tacagttggg ccctgtacca tcccaagtcc     4920

tttgtagctc ctcttgaaca tgtttgccat acttttaaaa gggtagttga ataaatagca     4980

tcaccattct ttgctgtggc acaggttata aacttaagtg gagtttaccg gcagcatcaa     5040

atgtttcagc tttaaaaaat aaaagtaggg tacaagttta atgtttagtt ctagaaattt     5100

tgtgcaatat gttcataacg atggctgtgg ttgccacaaa gtgcctcgtt tacctttaaa     5160

tactgttaat gtgtcatgca tgcagatgga aggggtggaa ctgtgcacta aagtgggggc     5220

tttaactgta gtatttggca gagttgcctt ctacctgcca gttcaaaagt tcaacctgtt     5280

ttcatataga atatatatac taaaaaattt cagtctgtta aacagcctta ctctgattca     5340

gcctcttcag atactcttgt gctgtgcagc agtggctctg tgtgtaaatg ctatgcactg     5400

aggatacaca aaaataccaa tatgatgtgt acaggataat gcctcatccc aatcagatgt     5460

ccatttgtta ttgtgtttgt taacaaccct ttatctctta gtgttataaa ctccacttaa     5520

aactgattaa agtctcattc ttgtcattgt gtgggtgttt tattaaatga gagtttataa     5580

ttcaaattgc ttaagtccat tgaagtttta attaatgggc agccaaatgt gaatacaaag     5640

ttttcagttt ttttttttcc tgctgtcctt caaagcctac tgtttaaaaa aaaaaaaaaa     5700

aaaaaacatg gcctgagagt agagtatctg tctactcatg tttaattaag gaaaaacact     5760

tatttttagg gctttagtca tcacttcata aattgtataa gcacattaaa tagcgttcta     5820

gtcctgaaaa agtccaagat tcttagaaaa ttgtgcatat ttttattatg acagatgttt     5880

gaagataatt ccccagaatg gatttgatac tttagatttc aattttgtgg cttttgtcta     5940

ttattctgta ctctgccatc agcatatgga aagcttcatt tactcatcat gacttgtgcc     6000

atataaaaat tgatatttcg gaatagtcta aaggactttt tgtacttgaa tttaatcatg     6060

ttgtttctaa tattcttaaa agcttgaaga ctaaagcata tcctttcaac aaagcatagt     6120

aaggtaataa gaaagtgtag tttgtacaag tgttaaaaaa ataaagtaga caatgttaca     6180

gtgggactta ttatttcaag tttacatttt ctccatgtaa ttttttaaaa agtaaatgaa     6240

aaaatgtgca ataatgtaaa atatgaagtg tatgtgtaca cacattttat ttttcggtat     6300

cttgggtata cgtatggttg aaaactatac tggagtctaa aagtattcta atttataaga     6360

agacattttg gtgatgtttg aaaaatagaa atgtgctagt tttgttttta tatcatgtcc     6420

tttgtacgtt gtaatatgag ctggcttggt tcagtaaatg ccatcaccat ttccattgag     6480

aatttaaaac tcaccagtgt ttaatatgca ggcttccaaa ggcttatgaa aaaaatcaag     6540

acccttaaat ctagttaatt tgctgctaac atgaaactct ttggttcttt tatttttgcc     6600

agataattag acacacatct aaagcttagt cttaaatggc ttaagtgtag ctattgatta     6660

gtgctgttgc tagttcagaa agaaatgttt gtgaatggaa acaagaatat tcagtccaaa     6720

ctgttgtaag gacagtacct gaaaaccagg aaacaggata atggaaaaag tcttttaaag     6780

atgaaatgtt ggagccaact ttcttataga attaattgta tgtggctata gaaagcctaa     6840

tgattgttgc ttatttttga gagcatatta ttcttttatg accataatct tgctgttttt     6900

ccatcttcca aaagatcttc cttctaatat gtatatcaga atgtgggtag ccagtcagac     6960

aaattcatat tggttggtag ctttaaaaag tttgtaatgt gaagacagga aaggacaaaa     7020

tagtttgctt tggtggtagt actctggttg ttaagctagg tattttgaga ctacttcccc     7080

atcacaacaa caataaaata atcactcata atcctatcac ctggagacat agccatcgtt     7140

aatatgttag tgactataca atcatgtttt cttctgtata tccatgtata ttctttaaaa     7200

atgaaattta tactgtacct gatctcaaag ctttttagct tagtatatct gtcatgaatt     7260

tgtaggatgt tccattgcat cagaaaacgg acagtgattt gattactttc taatgccaca     7320

gatgcagatt acatgtagtt attgagaatc ctttcgaatt cagtggctta atcatgaatg     7380

tctaaatatt gttgacatta ggatgataca tgtaaattaa agttacattt gtttagcata     7440

gacaagctta acattgtaga tgtttctctt caaaaatcat cttaaacatt tgcatttgga     7500

attgtgttaa atagaatgtg tgaaacactg tattagtaaa cttcatcacc tttctacttc     7560

cttatagttt gaacttttca gtttttgtag ttcccaaaca gttgctcaat ttagagcaaa     7620

ttaatttaac acctgccaaa aaaaggctgc tgttggctta tcagttgtct ttaaattcaa     7680

atgctcatgt gacttttatc acatcaaaaa atatttcatt aatgattcac ctttagctct     7740

gaaaattacc gcgtttagta attatagtgg gcttataaaa acatgcaact ctttttgata     7800

gttatttgag aattttggtg aaaaatattt agctgagggc agtatagaac ttataaacca     7860

atatattgat atttttaaaa catttttaca tataagtaaa ctgccatctt tgagcataac     7920

tacatttaaa aataaagctg catattttta aatcaagtgt ttaacaagaa tttatatttt     7980

ttatttttta aaattaaaaa taatttatat ttcctctgtt gcatgaggat tctcatctgt     8040

gcttataatg gttagagatt ttatttgtgt ggaatgaagt gaggcttgta gtcatggttc     8100

tagtgtttca gtttgccaag tctgtttact gcagtgaaat tcatcaaatg tttcagtgtg     8160

gttttctgta gcctatcatt tactggctat ttttttatgt acacctttag gattttctgc     8220

ctactctatc cagttgtcca aatgatatcc tacattttac aaatgccctt tcagtttcta     8280

ttttcttttt ccattaaatt gccctcatgt cctaatgtgc agtttgtaag tgtgtgtgtg     8340

tgtgtctgtg tgtgtgtgaa tttgattttc aagagtgcta gacttccaat ttgagagatt     8400

aaataattta attcaggcaa acatttttca ttggaatttc acagttcatt gtaatgaaaa     8460

tgttaatcct ggatgacctt tgacatacag taatgaatct tggatattaa tgaatttgtt     8520

agtagcatct tgatgtgtgt tttaatgagt tattttcaaa gttgtgcatt aaaccaaagt     8580

tggcatactg gaagtgttta tatcaagttc catttggcta ctgatggaca aaaaatagaa     8640

atgccttcct atggagagta tttttccttt aaaaaattaa aaaggttaat tattttgact     8700

aaaaaaaaaa aaaaaaaa                                                   8718


<210> 3
<211> 900
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Thr Cys Ala Val Glu Val Phe Gly Leu Leu Glu Asp Glu Glu 
1               5                   10                  15      


Asn Ser Arg Ile Val Arg Val Arg Val Ile Ala Gly Ile Gly Leu Ala 
            20                  25                  30          


Lys Lys Asp Ile Leu Gly Ala Ser Asp Pro Tyr Val Arg Val Thr Leu 
        35                  40                  45              


Tyr Asp Pro Met Asn Gly Val Leu Thr Ser Val Gln Thr Lys Thr Ile 
    50                  55                  60                  


Lys Lys Ser Leu Asn Pro Lys Trp Asn Glu Glu Ile Leu Phe Arg Val 
65                  70                  75                  80  


His Pro Gln Gln His Arg Leu Leu Phe Glu Val Phe Asp Glu Asn Arg 
                85                  90                  95      


Leu Thr Arg Asp Asp Phe Leu Gly Gln Val Asp Val Pro Leu Tyr Pro 
            100                 105                 110         


Leu Pro Thr Glu Asn Pro Arg Leu Glu Arg Pro Tyr Thr Phe Lys Asp 
        115                 120                 125             


Phe Val Leu His Pro Arg Ser His Lys Ser Arg Val Lys Gly Tyr Leu 
    130                 135                 140                 


Arg Leu Lys Met Thr Tyr Leu Pro Lys Thr Ser Gly Ser Glu Asp Asp 
145                 150                 155                 160 


Asn Ala Glu Gln Ala Glu Glu Leu Glu Pro Gly Trp Val Val Leu Asp 
                165                 170                 175     


Gln Pro Asp Ala Ala Cys His Leu Gln Gln Gln Gln Glu Pro Ser Pro 
            180                 185                 190         


Leu Pro Pro Gly Trp Glu Glu Arg Gln Asp Ile Leu Gly Arg Thr Tyr 
        195                 200                 205             


Tyr Val Asn His Glu Ser Arg Arg Thr Gln Trp Lys Arg Pro Thr Pro 
    210                 215                 220                 


Gln Asp Asn Leu Thr Asp Ala Glu Asn Gly Asn Ile Gln Leu Gln Ala 
225                 230                 235                 240 


Gln Arg Ala Phe Thr Thr Arg Arg Gln Ile Ser Glu Glu Thr Glu Ser 
                245                 250                 255     


Val Asp Asn Arg Glu Ser Ser Glu Asn Trp Glu Ile Ile Arg Glu Asp 
            260                 265                 270         


Glu Ala Thr Met Tyr Ser Asn Gln Ala Phe Pro Ser Pro Pro Pro Ser 
        275                 280                 285             


Ser Asn Leu Asp Val Pro Thr His Leu Ala Glu Glu Leu Asn Ala Arg 
    290                 295                 300                 


Leu Thr Ile Phe Gly Asn Ser Ala Val Ser Gln Pro Ala Ser Ser Ser 
305                 310                 315                 320 


Asn His Ser Ser Arg Arg Gly Ser Leu Gln Ala Tyr Thr Phe Glu Glu 
                325                 330                 335     


Gln Pro Thr Leu Pro Val Leu Leu Pro Thr Ser Ser Gly Leu Pro Pro 
            340                 345                 350         


Gly Trp Glu Glu Lys Gln Asp Glu Arg Gly Arg Ser Tyr Tyr Val Asp 
        355                 360                 365             


His Asn Ser Arg Thr Thr Thr Trp Thr Lys Pro Thr Val Gln Ala Thr 
    370                 375                 380                 


Val Glu Thr Ser Gln Leu Thr Ser Ser Gln Ser Ser Ala Gly Pro Gln 
385                 390                 395                 400 


Ser Gln Ala Ser Thr Ser Asp Ser Gly Gln Gln Val Thr Gln Pro Ser 
                405                 410                 415     


Glu Ile Glu Gln Gly Phe Leu Pro Lys Gly Trp Glu Val Arg His Ala 
            420                 425                 430         


Pro Asn Gly Arg Pro Phe Phe Ile Asp His Asn Thr Lys Thr Thr Thr 
        435                 440                 445             


Trp Glu Asp Pro Arg Leu Lys Ile Pro Ala His Leu Arg Gly Lys Thr 
    450                 455                 460                 


Ser Leu Asp Thr Ser Asn Asp Leu Gly Pro Leu Pro Pro Gly Trp Glu 
465                 470                 475                 480 


Glu Arg Thr His Thr Asp Gly Arg Ile Phe Tyr Ile Asn His Asn Ile 
                485                 490                 495     


Lys Arg Thr Gln Trp Glu Asp Pro Arg Leu Glu Asn Val Ala Ile Thr 
            500                 505                 510         


Gly Pro Ala Val Pro Tyr Ser Arg Asp Tyr Lys Arg Lys Tyr Glu Phe 
        515                 520                 525             


Phe Arg Arg Lys Leu Lys Lys Gln Asn Asp Ile Pro Asn Lys Phe Glu 
    530                 535                 540                 


Met Lys Leu Arg Arg Ala Thr Val Leu Glu Asp Ser Tyr Arg Arg Ile 
545                 550                 555                 560 


Met Gly Val Lys Arg Ala Asp Phe Leu Lys Ala Arg Leu Trp Ile Glu 
                565                 570                 575     


Phe Asp Gly Glu Lys Gly Leu Asp Tyr Gly Gly Val Ala Arg Glu Trp 
            580                 585                 590         


Phe Phe Leu Ile Ser Lys Glu Met Phe Asn Pro Tyr Tyr Gly Leu Phe 
        595                 600                 605             


Glu Tyr Ser Ala Thr Asp Asn Tyr Thr Leu Gln Ile Asn Pro Asn Ser 
    610                 615                 620                 


Gly Leu Cys Asn Glu Asp His Leu Ser Tyr Phe Lys Phe Ile Gly Arg 
625                 630                 635                 640 


Val Ala Gly Met Ala Val Tyr His Gly Lys Leu Leu Asp Gly Phe Phe 
                645                 650                 655     


Ile Arg Pro Phe Tyr Lys Met Met Leu His Lys Pro Ile Thr Leu His 
            660                 665                 670         


Asp Met Glu Ser Val Asp Ser Glu Tyr Tyr Asn Ser Leu Arg Trp Ile 
        675                 680                 685             


Leu Glu Asn Asp Pro Thr Glu Leu Asp Leu Arg Phe Ile Ile Asp Glu 
    690                 695                 700                 


Glu Leu Phe Gly Gln Thr His Gln His Glu Leu Lys Asn Gly Gly Ser 
705                 710                 715                 720 


Glu Ile Val Val Thr Asn Lys Asn Lys Lys Glu Tyr Ile Tyr Leu Val 
                725                 730                 735     


Ile Gln Trp Arg Phe Val Asn Arg Ile Gln Lys Gln Met Ala Ala Phe 
            740                 745                 750         


Lys Glu Gly Phe Phe Glu Leu Ile Pro Gln Asp Leu Ile Lys Ile Phe 
        755                 760                 765             


Asp Glu Asn Glu Leu Glu Leu Leu Met Cys Gly Leu Gly Asp Val Asp 
    770                 775                 780                 


Val Asn Asp Trp Arg Glu His Thr Lys Tyr Lys Asn Gly Tyr Ser Ala 
785                 790                 795                 800 


Asn His Gln Val Ile Gln Trp Phe Trp Lys Ala Val Leu Met Met Asp 
                805                 810                 815     


Ser Glu Lys Arg Ile Arg Leu Leu Gln Phe Val Thr Gly Thr Ser Arg 
            820                 825                 830         


Val Pro Met Asn Gly Phe Ala Glu Leu Tyr Gly Ser Asn Gly Pro Gln 
        835                 840                 845             


Ser Phe Thr Val Glu Gln Trp Gly Thr Pro Glu Lys Leu Pro Arg Ala 
    850                 855                 860                 


His Thr Cys Phe Asn Arg Leu Asp Leu Pro Pro Tyr Glu Ser Phe Glu 
865                 870                 875                 880 


Glu Leu Trp Asp Lys Leu Gln Met Ala Ile Glu Asn Thr Gln Gly Phe 
                885                 890                 895     


Asp Gly Val Asp 
            900 


<210> 4
<211> 7240
<212> DNA
<213> Homo sapiens

<400> 4
gctgcagctg agctcagctt aaaggtcgct ggaaatcaag tgctttgtaa gtgaaggcat       60

tttgactaca agcgattcaa gacattttgg aaacgtcagt ctctggaatg ggtcgtcttt      120

ttctttctat gatatctggt atctaatgtt ttacttagga taaagactac tacttaatag      180

ctcttttagg caccacaaat gattttttct tttgatgcag tgcagctgct tctagcctgt      240

ctacggacag agatctttgt tatgactttc agcccttaac atgtttggaa atgagaacaa      300

atggcacaaa gcttacgatt gcactttgca gccagaagaa gcaatactta ccctttgtca      360

gaaacctccg gagatgactt ggatagccat gttcacatgt gcttcaaaag accaacacgg      420

atttcaacgt ctaacgttgt tcaaatgaag ctgactccca gacagactgc actagctccg      480

ttaataaagg aaaacgttca gtctcaagaa agatcatctg ttccctcatc tgaaaatgtt      540

aataaaaaga gcagctgtct acagatttca ctacagccaa caaggtacag tggatatctt      600

cagtctagca atgtcttagc tgatagtgat gatgcttcgt ttacttgtat cttgaaggat      660

ggtatttaca gtagtgctgt ggtcgataat gaattgaatg ctgtgaatga tggtcacctt      720

gtaagcagtc cagccatttg tagtggtagc cttagtaact tttcaaccag tgataatggg      780

tcttacagca gcaacggtag tgattttggg tcatgtgcaa gtatcacaag tggaggttca      840

tatactaaca gtgtcatcag tgacagtagt agttatactt ttccaccaag tgatgatact      900

tttttgggtg gaaacttacc ttctgacagc acctccaata gaagtgtgcc aaacaggaat      960

actactcctt gtgaaatttt ttcaagaagt acaagtacag atccttttgt ccaggatgac     1020

ttggaacatg gattagagat tatgaaattg ccagtgagca ggaacacaaa aattccacta     1080

aaacgttact cctccttagt catttttcct aggagtcctt caactacccg accgacttct     1140

ccaacaagtc tgtgtactct tctgagcaaa ggatcctatc aaacttcaca ccagtttatt     1200

atttctccta gtgaaattgc acataatgag gatggcacta gtgctaaagg atttctttca     1260

acagctgtca atggacttcg gttatctaaa acaatttgta cccccggaga agtaagagac     1320

atacggccgc ttcacaggaa gggctcgtta cagaagaaaa ttgttctttc gaataatact     1380

cccagacaga ctgtctgtga aaagtcatct gaaggatatt cttgtgtttc agtgcatttc     1440

acccaacgaa aagcagctac attagactgt gaaacaacaa atggtgattg taaaccagaa     1500

atgtcagaaa ttaagcttaa ttctgattca gagtatatta agctcatgca taggacatct     1560

gcatgtttgc catcctccca aaatgtagat tgtcaaataa atatcaatgg agaattggaa     1620

agaccacatt cacagatgaa caaaaaccat ggtattttac gaagaagtat ttcattggga     1680

ggagcttatc caaatatttc ctgtctatcc agccttaagc acaattgttc taaaggggga     1740

ccatctcagt tactcataaa gtttgcatct ggaaatgaag gtaaagtgga taatttatca     1800

agagacagca acagagattg cacaaatgaa ctgtctaatt cttgcaagac aagagatgat     1860

ttcctaggtc aagtggatgt tccactttat ccattaccga cagaaaatcc aagattggag     1920

agaccatata catttaagga ttttgttctt catccaagaa gtcacaaatc aagagttaaa     1980

ggttatctga gactaaaaat gacttattta cctaaaacca gtggctcaga agatgataat     2040

gcagaacagg ctgaggaatt agagcctggc tgggttgttt tggaccaacc agatgctgct     2100

tgccatttgc agcaacaaca agaaccttct cctctacctc cagggtggga agagaggcag     2160

gatatccttg gaaggaccta ttatgtaaac catgaatcta gaagaacaca gtggaaaaga     2220

ccaacccctc aggacaacct aacagatgct gagaatggca acattcaact gcaagcacaa     2280

cgtgcattta ccaccaggcg gcagatatcc gaggaaacag aaagtgttga caaccgagag     2340

tcttccgaga actgggaaat tataagagaa gatgaagcca ccatgtatag caaccaggcc     2400

ttcccatcac ctccaccgtc aagtaacttg gatgttccaa ctcatcttgc agaagaattg     2460

aatgccagac tcaccatttt tggaaattca gccgtgagcc agccagcatc gagctcaaat     2520

cattccagca gaagaggcag cttacaagcc tatacttttg aggaacaacc tacacttcct     2580

gtgcttttgc ctacttcatc tggattacca ccaggttggg aagaaaaaca agatgaaaga     2640

ggaagatcat attatgtaga tcacaattcc agaacgacta cttggacaaa gcccactgta     2700

caggccacag tggagaccag tcagctgacc tcaagccaga gttctgcagg ccctcaatca     2760

caagcctcca ccagtgattc aggccagcag gtgacccagc catctgaaat tgagcaagga     2820

ttccttccta aaggctggga agtccggcat gcaccaaatg ggaggccttt ctttattgac     2880

cacaacacta aaaccaccac ctgggaagat ccaagattga aaattccagc ccatctgaga     2940

ggaaagacat cacttgatac ttccaatgat ctagggcctt tacctccagg atgggaagag     3000

agaactcaca cagatggaag aatcttctac ataaatcaca atataaaaag aacacaatgg     3060

gaagatcctc ggttggagaa tgtagcaata actggaccag cagtgcccta ctccagggat     3120

tacaaaagaa agtatgagtt cttccgaaga aagttgaaga agcagaatga cattccaaac     3180

aaatttgaaa tgaaacttcg ccgagcaact gttcttgaag actcttaccg gagaattatg     3240

ggtgtcaaga gagcagactt cctgaaggct cgactgtgga ttgagtttga tggtgaaaag     3300

ggattggatt atggaggagt tgccagagaa tggttcttcc tgatctcaaa ggaaatgttt     3360

aacccttatt atgggttgtt tgaatattct gctacggaca attataccct acagataaat     3420

ccaaactctg gattgtgtaa cgaagatcac ctctcttact tcaagtttat tggtcgggta     3480

gctggaatgg cagtttatca tggcaaactg ttggatggtt ttttcatccg cccattttac     3540

aagatgatgc ttcacaaacc aataaccctt catgatatgg aatctgtgga tagtgaatat     3600

tacaattccc taagatggat tcttgaaaat gacccaacag aattggacct caggtttatc     3660

atagatgaag aactttttgg acagacacat caacatgagc tgaaaaatgg tggatcagaa     3720

atagttgtca ccaataagaa caaaaaggaa tatatttatc ttgtaataca atggcgattt     3780

gtaaaccgaa tccagaagca aatggctgct tttaaagagg gattctttga actaatacca     3840

caggatctca tcaaaatttt tgatgaaaat gaactagagc ttcttatgtg tggactggga     3900

gatgttgatg tgaatgactg gagggaacat acaaagtata aaaatggcta cagtgcaaat     3960

catcaggtta tacagtggtt ttggaaggct gttttaatga tggattcaga aaaaagaata     4020

agattacttc agtttgtcac tggcacatct cgggtgccta tgaatggatt tgctgaacta     4080

tacggttcaa atggaccaca gtcatttaca gttgaacagt ggggtactcc tgaaaagctg     4140

ccaagagctc atacctgttt taatcgcctg gacttgccac cttatgaatc atttgaagaa     4200

ttatgggata aacttcagat ggcaattgaa aacacccagg gctttgatgg agttgattag     4260

attacaaata acaatctgta gtgtttttac tgccatagtt ttataaccaa aatcttgact     4320

taaaattttc cggggaacta ctaaaatgtg gccactgagt cttcccagat cttgaagaaa     4380

atcatataaa aagcatttga agaaatagta cgacaactta tttttaatca cttttaaata     4440

atgtgttgca tttacacagt tgtttcatgc tgtctttaga gttaggtgcc tgcctaaagc     4500

caggcaccac cacacctggc tttagagttc acacaatagg atataagtcc tgtatgactt     4560

aaatagtgaa ttttgtcctt aacatttacc tcttgtatag tatctgccag gcagtttttt     4620

cttaaactac tgagatgata actgtgaaat atttgtgata cgtgtcatgt gtgaaaagtt     4680

tgatgcattt tgagatggaa aactgaaatt tggaaaaaga aatactttac tattgagtaa     4740

actacaatat atttagtgct actcgcagct atttattatt ttgtagacct gccttatgca     4800

ccttactgcc tagatttttg ggaaaaaact ttggaaagtg tgttacctat atttctagcc     4860

aactaactca cagaaaaact gtttacttct tcactttcga agtatttggc ttttgttaat     4920

atgcagtttt actaaacaga tggttcataa gacatgtgaa gcaaattcat atttgcaatg     4980

ggtaaaaagt attaaagcct ttctcttgcc tgcatatcct attgaccatt ggtatagtca     5040

tcactttttc atattttagt gtagttagaa gaattccttc ttcaaacatt aaagatccac     5100

aaagcagtat ttctaaatat gccttgaaga actaaatgaa gtgtatagca cttgccttta     5160

ctagatattc tttacacttg tacaattatg tagtaaatgt atgtttacag ggtttatcat     5220

gtttacagat taagctaatt tctgtagtcg catttttata tttttagtat cactctagta     5280

aaaaaaccaa ataatttgtt taaaataacc aaagagttgt tataatgcat aatttgtatt     5340

aaatttatta ctatttctta tgccttttaa aatactgttt actatgaaga caatgttttt     5400

aattacaaat ccagaattct gtaggcaaaa tgctacagtt catatcttcc tttaaccaaa     5460

ctgaagtaca taaagaccat gtacatgtat tcatcaaacg tttattgaat gctgcgtgcc     5520

tagcgctgtg ctatgctctg gggtaagagt tgtcagcttc agagaagctg agtcctgatc     5580

ctcaaggaac ttgcaaatgt gtctatgaat ttgtaaaaca atcaaaagta ggcgtaagca     5640

gaataaggca aaagggaaag tgttctaggt tccagcacac ctgcaaagat aaagtgtgcc     5700

aagactgtat ttatatttca tacttatatt gtttcatcct tatattggaa tgattatata     5760

gaaaatgctc ttaaaaagat taaacctatt tctcagtatg gtatcttggt gatttaggaa     5820

taattgtaaa tatatgttac gaatcttctt aaatatatat atatacacac cctgtgagaa     5880

ctgtaaaaag tacctctggt tcttggttta agtttgttgg ggtataacat gatgagtact     5940

cattagcacc tgatagaaat ctgaaatgtg acagtagcaa aaccactttc tactttccaa     6000

acaccacagc atcagcatgg tttaggggaa gcaattcaca gattaatgta ccctgcgttt     6060

tgtcttcacc attgtcaacc agcagtcaag gatgagcacc aggtatagtc ctggtttgat     6120

atctcaccag ccatgtgaac tgaagcagct tacttaacct ctctggattc atatttcttc     6180

atctgtcaaa tgagagtaat catgcccacc ctcattgtca tgccagattg tcagaagttc     6240

cagacagatg agaaagcaaa aagtactttg taaagtgtta tacaatcaga aggtgctttg     6300

tgctgaccgt cagattgtgt caagtcaggt gtgcaaattg accacactcc caaagaatca     6360

tttaaaagta aagtgacttc taagagacaa ggaagtagga acatttctga tattaaatat     6420

ataaataata tggatacaca tgtgtatatc tgtatatgga tcttaccatc ataattcatt     6480

ttcttcatat cagcaaagta atagtaatgt gggccaatgc attttggaaa tgtcctcatt     6540

atgtagaatg gaatgtgaaa attatttttg ttaaaacagg attttgccac aattatttaa     6600

atattatgtt tgtgaactat ctaagcatga gaaaatacaa agctttcttt gtatctggct     6660

gatactcatt tggatgattc tgtgactcat agaacatgat gttaaatgag accagactca     6720

actgccacca gtccccagct gcagaccttc atccccttca tctcccacta ggggctcgtg     6780

gtctggaaga aacatctatc aagcaacaca gccccttatc ccagatagaa aagtgtctca     6840

aatgcattct actgcgggac agtcagtagg atcattttca taaagcaagg acatcatatg     6900

tttctagaaa ttacaagcat ataactttag cctacaatct cttattaaaa atttttaaca     6960

aaattgtatt acaaatgcat ttcatcagaa ctcaaattta aatggtgttt gttttgggtt     7020

tttatttata atgctgaagt tattccatat aagtatcaag ttaaacacaa ttcattttga     7080

ttataaacta tttgactttt taaaatcttc tgacacagta aatatatata tcaagattga     7140

tgtatcaaaa tttattgcac actttaaagt gtaaaatcat tttttaaaat cttgaatcca     7200

caaataaagt tctattctga ttttaaaaaa caaaacaaaa                           7240


<210> 5
<211> 922
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Thr Ala Ser Pro Arg Ser Asp Thr Ser Asn Asn His Ser Gly 
1               5                   10                  15      


Arg Leu Gln Leu Gln Val Thr Val Ser Ser Ala Lys Leu Lys Arg Lys 
            20                  25                  30          


Lys Asn Trp Phe Gly Thr Ala Ile Tyr Thr Glu Val Val Val Asp Gly 
        35                  40                  45              


Glu Ile Thr Lys Thr Ala Lys Ser Ser Ser Ser Ser Asn Pro Lys Trp 
    50                  55                  60                  


Asp Glu Gln Leu Thr Val Asn Val Thr Pro Gln Thr Thr Leu Glu Phe 
65                  70                  75                  80  


Gln Val Trp Ser His Arg Thr Leu Lys Ala Asp Ala Leu Leu Gly Lys 
                85                  90                  95      


Ala Thr Ile Asp Leu Lys Gln Ala Leu Leu Ile His Asn Arg Lys Leu 
            100                 105                 110         


Glu Arg Val Lys Glu Gln Leu Lys Leu Ser Leu Glu Asn Lys Asn Gly 
        115                 120                 125             


Ile Ala Gln Thr Gly Glu Leu Thr Val Val Leu Asp Gly Leu Val Ile 
    130                 135                 140                 


Glu Gln Glu Asn Ile Thr Asn Cys Ser Ser Ser Pro Thr Ile Glu Ile 
145                 150                 155                 160 


Gln Glu Asn Gly Asp Ala Leu His Glu Asn Gly Glu Pro Ser Ala Arg 
                165                 170                 175     


Thr Thr Ala Arg Leu Ala Val Glu Gly Thr Asn Gly Ile Asp Asn His 
            180                 185                 190         


Val Pro Thr Ser Thr Leu Val Gln Asn Ser Cys Cys Ser Tyr Val Val 
        195                 200                 205             


Asn Gly Asp Asn Thr Pro Ser Ser Pro Ser Gln Val Ala Ala Arg Pro 
    210                 215                 220                 


Lys Asn Thr Pro Ala Pro Lys Pro Leu Ala Ser Glu Pro Ala Asp Asp 
225                 230                 235                 240 


Thr Val Asn Gly Glu Ser Ser Ser Phe Ala Pro Thr Asp Asn Ala Ser 
                245                 250                 255     


Val Thr Gly Thr Pro Val Val Ser Glu Glu Asn Ala Leu Ser Pro Asn 
            260                 265                 270         


Cys Thr Ser Thr Thr Val Glu Asp Pro Pro Val Gln Glu Ile Leu Thr 
        275                 280                 285             


Ser Ser Glu Asn Asn Glu Cys Ile Pro Ser Thr Ser Ala Glu Leu Glu 
    290                 295                 300                 


Ser Glu Ala Arg Ser Ile Leu Glu Pro Asp Thr Ser Asn Ser Arg Ser 
305                 310                 315                 320 


Ser Ser Ala Phe Glu Ala Ala Lys Ser Arg Gln Pro Asp Gly Cys Met 
                325                 330                 335     


Asp Pro Val Arg Gln Gln Ser Gly Asn Ala Asn Thr Glu Thr Leu Pro 
            340                 345                 350         


Ser Gly Trp Glu Gln Arg Lys Asp Pro His Gly Arg Thr Tyr Tyr Val 
        355                 360                 365             


Asp His Asn Thr Arg Thr Thr Thr Trp Glu Arg Pro Gln Pro Leu Pro 
    370                 375                 380                 


Pro Gly Trp Glu Arg Arg Val Asp Asp Arg Arg Arg Val Tyr Tyr Val 
385                 390                 395                 400 


Asp His Asn Thr Arg Thr Thr Thr Trp Gln Arg Pro Thr Met Glu Ser 
                405                 410                 415     


Val Arg Asn Phe Glu Gln Trp Gln Ser Gln Arg Asn Gln Leu Gln Gly 
            420                 425                 430         


Ala Met Gln Gln Phe Asn Gln Arg Tyr Leu Tyr Ser Ala Ser Met Leu 
        435                 440                 445             


Ala Ala Glu Asn Asp Pro Tyr Gly Pro Leu Pro Pro Gly Trp Glu Lys 
    450                 455                 460                 


Arg Val Asp Ser Thr Asp Arg Val Tyr Phe Val Asn His Asn Thr Lys 
465                 470                 475                 480 


Thr Thr Gln Trp Glu Asp Pro Arg Thr Gln Gly Leu Gln Asn Glu Glu 
                485                 490                 495     


Pro Leu Pro Glu Gly Trp Glu Ile Arg Tyr Thr Arg Glu Gly Val Arg 
            500                 505                 510         


Tyr Phe Val Asp His Asn Thr Arg Thr Thr Thr Phe Lys Asp Pro Arg 
        515                 520                 525             


Asn Gly Lys Ser Ser Val Thr Lys Gly Gly Pro Gln Ile Ala Tyr Glu 
    530                 535                 540                 


Arg Gly Phe Arg Trp Lys Leu Ala His Phe Arg Tyr Leu Cys Gln Ser 
545                 550                 555                 560 


Asn Ala Leu Pro Ser His Val Lys Ile Asn Val Ser Arg Gln Thr Leu 
                565                 570                 575     


Phe Glu Asp Ser Phe Gln Gln Ile Met Ala Leu Lys Pro Tyr Asp Leu 
            580                 585                 590         


Arg Arg Arg Leu Tyr Val Ile Phe Arg Gly Glu Glu Gly Leu Asp Tyr 
        595                 600                 605             


Gly Gly Leu Ala Arg Glu Trp Phe Phe Leu Leu Ser His Glu Val Leu 
    610                 615                 620                 


Asn Pro Met Tyr Cys Leu Phe Glu Tyr Ala Gly Lys Asn Asn Tyr Cys 
625                 630                 635                 640 


Leu Gln Ile Asn Pro Ala Ser Thr Ile Asn Pro Asp His Leu Ser Tyr 
                645                 650                 655     


Phe Cys Phe Ile Gly Arg Phe Ile Ala Met Ala Leu Phe His Gly Lys 
            660                 665                 670         


Phe Ile Asp Thr Gly Phe Ser Leu Pro Phe Tyr Lys Arg Met Leu Ser 
        675                 680                 685             


Lys Lys Leu Thr Ile Lys Asp Leu Glu Ser Ile Asp Thr Glu Phe Tyr 
    690                 695                 700                 


Asn Ser Leu Ile Trp Ile Arg Asp Asn Asn Ile Glu Glu Cys Gly Leu 
705                 710                 715                 720 


Glu Met Tyr Phe Ser Val Asp Met Glu Ile Leu Gly Lys Val Thr Ser 
                725                 730                 735     


His Asp Leu Lys Leu Gly Gly Ser Asn Ile Leu Val Thr Glu Glu Asn 
            740                 745                 750         


Lys Asp Glu Tyr Ile Gly Leu Met Thr Glu Trp Arg Phe Ser Arg Gly 
        755                 760                 765             


Val Gln Glu Gln Thr Lys Ala Phe Leu Asp Gly Phe Asn Glu Val Val 
    770                 775                 780                 


Pro Leu Gln Trp Leu Gln Tyr Phe Asp Glu Lys Glu Leu Glu Val Met 
785                 790                 795                 800 


Leu Cys Gly Met Gln Glu Val Asp Leu Ala Asp Trp Gln Arg Asn Thr 
                805                 810                 815     


Val Tyr Arg His Tyr Thr Arg Asn Ser Lys Gln Ile Ile Trp Phe Trp 
            820                 825                 830         


Gln Phe Val Lys Glu Thr Asp Asn Glu Val Arg Met Arg Leu Leu Gln 
        835                 840                 845             


Phe Val Thr Gly Thr Cys Arg Leu Pro Leu Gly Gly Phe Ala Glu Leu 
    850                 855                 860                 


Met Gly Ser Asn Gly Pro Gln Lys Phe Cys Ile Glu Lys Val Gly Lys 
865                 870                 875                 880 


Asp Thr Trp Leu Pro Arg Ser His Thr Cys Phe Asn Arg Leu Asp Leu 
                885                 890                 895     


Pro Pro Tyr Lys Ser Tyr Glu Gln Leu Lys Glu Lys Leu Leu Phe Ala 
            900                 905                 910         


Ile Glu Glu Thr Glu Gly Phe Gly Gln Glu 
        915                 920         


<210> 6
<211> 4120
<212> DNA
<213> Homo sapiens

<400> 6
ggctgctggc ggcctgggct gccggggccg acgcctgggt ggctgctgcc gccgcgcctg       60

ctgcgagatg gcgatcttgg gcgcggaagg gtgagggcgc ccgccgcagg aggaggtgcc      120

gctgccgtgg ccgcccggct gccgggagcc gacagcttcg cgccggggtt gtctcctcac      180

agactatgag ctccttgaaa gagggaatcg tgtcttactc atctttgtat ccccagtgtc      240

tagcagttcc tgatacatag ttttagctga attttgggac atggccactg cttcaccaag      300

gtctgatact agtaataacc acagtggaag gttgcagtta caggtaactg tttctagtgc      360

caaacttaaa agaaaaaaga actggttcgg aacagcaata tatacagaag tagttgtaga      420

tggagaaatt acgaaaacag caaaatccag tagttcttct aatccaaaat gggatgaaca      480

gctaactgta aatgttacgc cacagactac attggaattt caagtttgga gccatcgcac      540

tttaaaagca gatgctttat taggaaaagc aacgatagat ttgaaacaag ctctgttgat      600

acacaataga aaattggaaa gagtgaaaga acaattaaaa ctttccttgg aaaacaagaa      660

tggcatagca caaactggtg aattgacagt tgtgcttgat ggattggtga ttgagcaaga      720

aaatataaca aactgcagct catctccaac catagaaata caggaaaatg gtgatgcctt      780

acatgaaaat ggagagcctt cagcaaggac aactgccagg ttggctgttg aaggcacgaa      840

tggaatagat aatcatgtac ctacaagcac tctagtccaa aactcatgct gctcgtatgt      900

agttaatgga gacaacacac cttcatctcc gtctcaggtt gctgccagac ccaaaaatac      960

accagctcca aaaccactcg catctgagcc tgccgatgac actgttaatg gagaatcatc     1020

ctcatttgca ccaactgata atgcgtctgt cacgggtact ccagtagtgt ctgaagaaaa     1080

tgccttgtct ccaaattgca ctagtactac tgttgaagat cctccagttc aagaaatact     1140

gacttcctca gaaaacaatg aatgtattcc ttctaccagt gcagaattgg aatctgaagc     1200

tagaagtata ttagagcctg acacctctaa ttctagaagt agttctgctt ttgaagcagc     1260

caaatcaaga cagccagatg ggtgtatgga tcctgtacgg cagcagtctg ggaatgccaa     1320

cacagaaacc ttgccatcag ggtgggaaca aagaaaagat cctcatggta gaacctatta     1380

tgtggatcat aatactcgaa ctaccacatg ggagagacca caacctttac ctccaggttg     1440

ggaaagaaga gttgatgatc gtagaagagt ttattatgtg gatcataaca ccagaacaac     1500

aacgtggcag cggcctacca tggaatctgt ccgaaatttt gaacagtggc aatctcagcg     1560

gaaccaattg cagggagcta tgcaacagtt taaccaacga tacctctatt cggcttcaat     1620

gttagctgca gaaaatgacc cttatggacc tttgccacca ggctgggaaa aaagagtgga     1680

ttcaacagac agggtttact ttgtgaatca taacacaaaa acaacccagt gggaagatcc     1740

aagaactcaa ggcttacaga atgaagaacc cctgccagaa ggctgggaaa ttagatatac     1800

tcgtgaaggt gtaaggtact ttgttgatca taacacaaga acaacaacat tcaaagatcc     1860

tcgcaatggg aagtcatctg taactaaagg tggtccacaa attgcttatg aacgcggctt     1920

taggtggaag cttgctcact tccgttattt gtgccagtct aatgcactac ctagtcatgt     1980

aaagatcaat gtgtcccggc agacattgtt tgaagattcc ttccaacaga ttatggcatt     2040

aaaaccctat gacttgagga ggcgcttata tgtaatattt agaggagaag aaggacttga     2100

ttatggtggc ctagcgagag aatggttttt cttgctttca catgaagttt tgaacccaat     2160

gtattgctta tttgagtatg cgggcaagaa caactattgt ctgcagataa atccagcatc     2220

aaccattaat ccagaccatc tttcatactt ctgtttcatt ggtcgtttta ttgccatggc     2280

actatttcat ggaaagttta tcgatactgg tttctcttta ccattctaca agcgtatgtt     2340

aagtaaaaaa cttactatta aggatttgga atctattgat actgaatttt ataactccct     2400

tatctggata agagataaca acattgaaga atgtggctta gaaatgtact tttctgttga     2460

catggagatt ttgggaaaag ttacttcaca tgacctgaag ttgggaggtt ccaatattct     2520

ggtgactgag gagaacaaag atgaatatat tggtttaatg acagaatggc gtttttctcg     2580

aggagtacaa gaacagacca aagctttcct tgatggtttt aatgaagttg ttcctcttca     2640

gtggctacag tacttcgatg aaaaagaatt agaggttatg ttgtgtggca tgcaggaggt     2700

tgacttggca gattggcaga gaaatactgt ttatcgacat tatacaagaa acagcaagca     2760

aatcatttgg ttttggcagt ttgtgaaaga gacagacaat gaagtaagaa tgcgactatt     2820

gcagttcgtc actggaacct gccgtttacc tctaggagga tttgctgagc tcatgggaag     2880

taatgggcct caaaagtttt gcattgaaaa agttggcaaa gacacttggt taccaagaag     2940

ccatacatgt tttaatcgct tggatctacc accatataag agttatgaac aactaaagga     3000

aaaacttctt tttgcaatag aagagacaga gggatttgga caagaatgaa tgtggcttct     3060

tattttggag gagctcttgc atttaaatac cccagccaag aaaaattgca cagatagtgt     3120

atataagctg ttcattctgt acagtgaatt ttccgaacct ctcaaagtat gttttccgtt     3180

cttccacaga aatatgcaaa acagttcatc cttttctact ttatttattg ttcccttgaa     3240

atgactgacc aggaaaaaga tcatccttaa attttgaagc aagtgagaga ctttattaaa     3300

aatacatata tatctatata aacatatatg atagtggctc tagttttata gagctccaag     3360

tgtattaaac atgacagcca ttcattcata aagatctgga tttgctttac cttgttaata     3420

ttatctaggg gaaaaagtgc aaattgctcc atgttcttct ctcccttatg taacatctcc     3480

tgagggtgtt tagttgcatg gctgttcaga aaggtattaa gggcttaggc caaatcttac     3540

tttgagtatg ttaaaaaaaa aaaaatgctg ctggcttttc tgaagacagg tgcttgaact     3600

tgtcagtttg ttttaaataa atacaatagt tgaaaatttt tctctgttac atcagtaata     3660

ttgttaaagt aatggataga accataactt acacatgaaa gtcatatact agatccaata     3720

ctatttagtt tattatcgaa attggaagga ttcattgagc agcatagaag tttgtttaca     3780

tgttactttg agatgctagg tatttgtgga attaaaaaga atcaggctct tttgtacttt     3840

gtttttaaat ctgtgatgct tttcaaattt aattcataat aaattgatgc aatttcatac     3900

ttaggaacat acaaaaggta atgtaaactc tgccactttt ttgtgttcaa aattttggtt     3960

tttatgaagc cagatggatt gaagagttac ataagcattt gaatgctcta atataaggct     4020

aatgattttc tgttagtgtt tgaatatctt cattcctctc aaattcataa cagttctatt     4080

taactgaatt aaataaccat atgaaaaaaa aaaaaaaaaa                           4120


