                         SEQUENCE LISTING

<110>  PEPTINOV SAS
       CONSERVATOIRE NATIONAL DES ARTS ET METIERS
 
<120>  COMPOSITION VACCINALE ANTI-PD-1

<130>  B000081WO

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Fragment de PD-1

<400>  1

Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
1               5                   10                  15  


<210>  2
<211>  16
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Fragment de PD-1

<400>  2

Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala 
1               5                   10                  15      


<210>  3
<211>  16
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Fragment de PD-1

<400>  3

Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
1               5                   10                  15      


<210>  4
<211>  12
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Fragment de PD-1

<400>  4

Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn 
1               5                   10          


<210>  5
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  6
<211>  288
<212>  PRT
<213>  Mus musculus

<400>  6

Met Trp Val Arg Gln Val Pro Trp Ser Phe Thr Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Ser Trp Gln Ser Gly Trp Leu Leu Glu Val Pro Asn Gly Pro Trp 
            20                  25                  30          


Arg Ser Leu Thr Phe Tyr Pro Ala Trp Leu Thr Val Ser Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Leu Ser Asn Trp Ser Glu Asp Leu Met 
    50                  55                  60                  


Leu Asn Trp Asn Arg Leu Ser Pro Ser Asn Gln Thr Glu Lys Gln Ala 
65                  70                  75                  80  


Ala Phe Cys Asn Gly Leu Ser Gln Pro Val Gln Asp Ala Arg Phe Gln 
                85                  90                  95      


Ile Ile Gln Leu Pro Asn Arg His Asp Phe His Met Asn Ile Leu Asp 
            100                 105                 110         


Thr Arg Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


His Pro Lys Ala Lys Ile Glu Glu Ser Pro Gly Ala Glu Leu Val Val 
    130                 135                 140                 


Thr Glu Arg Ile Leu Glu Thr Ser Thr Arg Tyr Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Lys Pro Glu Gly Arg Phe Gln Gly Met Val Ile Gly Ile Met Ser Ala 
                165                 170                 175     


Leu Val Gly Ile Pro Val Leu Leu Leu Leu Ala Trp Ala Leu Ala Val 
            180                 185                 190         


Phe Cys Ser Thr Ser Met Ser Glu Ala Arg Gly Ala Gly Ser Lys Asp 
        195                 200                 205             


Asp Thr Leu Lys Glu Glu Pro Ser Ala Ala Pro Val Pro Ser Val Ala 
    210                 215                 220                 


Tyr Glu Glu Leu Asp Phe Gln Gly Arg Glu Lys Thr Pro Glu Leu Pro 
225                 230                 235                 240 


Thr Ala Cys Val His Thr Glu Tyr Ala Thr Ile Val Phe Thr Glu Gly 
                245                 250                 255     


Leu Gly Ala Ser Ala Met Gly Arg Arg Gly Ser Ala Asp Gly Leu Gln 
            260                 265                 270         


Gly Pro Arg Pro Pro Arg His Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  7
<211>  288
<212>  PRT
<213>  Macaca mulatta

<400>  7

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Glu Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Leu Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Ala Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Arg Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Ala Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Gln Gly Thr Ile Glu Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Ala Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Leu Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Pro Arg Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  8
<211>  286
<212>  PRT
<213>  Equus caballus

<400>  8

Met Gly Thr Leu Arg Ala Pro Trp Pro Phe Val Trp Val Leu Leu Gln 
1               5                   10                  15      


Leu Gly Trp Leu Pro Ala Trp Leu Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Arg Pro Leu Thr Phe Ser Pro Ala Arg Leu Met Val Pro Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu His Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Ser Ser Gln Pro Gly Arg Ser Gly Arg Phe Arg 
                85                  90                  95      


Val Thr Arg Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Leu Ala 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Pro Pro Lys Thr Gln Ile Asn Glu Ser Pro Arg Ala Glu Leu Thr Val 
    130                 135                 140                 


Thr Glu Arg Ile Pro Glu Pro Pro Thr Glu His Pro Ser Pro Pro Pro 
145                 150                 155                 160 


Ser Pro Ala Gly Gln Leu Gln Gly Leu Val Val Gly Ile Thr Ser Leu 
                165                 170                 175     


Leu Val Gly Val Leu Leu Val Leu Leu Leu Ala Cys Val Leu Thr Thr 
            180                 185                 190         


Thr Phe Pro Arg Ala Ala Arg Gly Ala Cys Gly Arg Ser Gly Asp Glu 
        195                 200                 205             


Pro Leu Glu Gly Pro Ser Ala Pro Pro Ala Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Ala Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Gly Arg 
                245                 250                 255     


Pro Gly Ser Gln Gly Arg Arg Ala Ser Ala Asp Asp Pro Gln Gly Pro 
            260                 265                 270         


Arg Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285     


<210>  9
<211>  287
<212>  PRT
<213>  Equus caballus

<400>  9

Met Gly Thr Leu Arg Ala Pro Trp Pro Phe Val Trp Val Leu Leu Gln 
1               5                   10                  15      


Leu Gly Trp Leu Pro Ala Trp Leu Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Arg Pro Leu Thr Phe Ser Pro Ala Arg Leu Met Val Pro Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu His Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Ser Ser Gln Pro Gly Arg Ser Gly Arg Phe Arg 
                85                  90                  95      


Val Thr Arg Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Leu Ala 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Pro Pro Lys Thr Gln Ile Asn Glu Ser Pro Arg Ala Glu Leu Thr Val 
    130                 135                 140                 


Thr Glu Arg Ile Pro Glu Pro Pro Thr Glu His Pro Ser Pro Pro Pro 
145                 150                 155                 160 


Ser Pro Ala Gly Gln Leu Gln Gly Leu Val Val Gly Ile Thr Ser Leu 
                165                 170                 175     


Leu Val Gly Val Leu Leu Val Leu Leu Leu Ala Cys Val Leu Thr Thr 
            180                 185                 190         


Thr Phe Pro Arg Ala Ala Arg Gly Ala Cys Gly Arg Ser Gly Asp Glu 
        195                 200                 205             


Pro Leu Lys Glu Gly Pro Ser Ala Pro Pro Ala Phe Ser Val Asp Tyr 
    210                 215                 220                 


Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Ala 
225                 230                 235                 240 


Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Gly 
                245                 250                 255     


Arg Pro Gly Ser Gln Gly Arg Arg Ala Ser Ala Asp Asp Pro Gln Gly 
            260                 265                 270         


Pro Arg Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285         


<210>  10
<211>  288
<212>  PRT
<213>  Canis familiaris

<400>  10

Met Gly Ser Arg Arg Gly Pro Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Trp Pro Gly Trp Leu Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Ser Pro Leu Thr Phe Ser Pro Ala Gln Leu Thr Val Gln Glu Gly Glu 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Leu Ala Asp Ile Pro Asp Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Leu Ser Pro Arg Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Gln Glu Asp Arg Ile Glu Pro Gly Arg Asp Arg Arg Phe Arg 
                85                  90                  95      


Val Thr Arg Leu Pro Asn Gly Arg Asp Phe His Met Ser Ile Val Ala 
            100                 105                 110         


Ala Arg Leu Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Asn Thr Gln Ile Asn Glu Ser Pro Arg Ala Glu Leu Ser Val 
    130                 135                 140                 


Thr Glu Arg Thr Leu Glu Pro Pro Thr Gln Ser Pro Ser Pro Pro Pro 
145                 150                 155                 160 


Arg Leu Ser Gly Gln Leu Gln Gly Leu Val Ile Gly Val Thr Ser Val 
                165                 170                 175     


Leu Val Gly Val Leu Leu Leu Leu Leu Leu Thr Trp Val Leu Ala Ala 
            180                 185                 190         


Val Phe Pro Arg Ala Thr Arg Gly Ala Cys Val Cys Gly Ser Glu Asp 
        195                 200                 205             


Glu Pro Leu Lys Glu Gly Pro Asp Ala Ala Pro Val Phe Thr Leu Asp 
    210                 215                 220                 


Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro 
225                 230                 235                 240 


Ala Pro Cys Ala Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro 
                245                 250                 255     


Gly Arg Pro Ala Ser Pro Gly Arg Arg Ala Ser Ala Ser Ser Leu Gln 
            260                 265                 270         


Gly Ala Gln Pro Pro Ser Pro Glu Asp Gly Pro Gly Leu Trp Pro Leu 
        275                 280                 285             


<210>  11
<211>  278
<212>  PRT
<213>  Felis catus

<400>  11

Met Gly Thr Pro Arg Ala Pro Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Trp Pro Gly Trp Leu Leu Asp Ser Pro Tyr Arg Pro Trp 
            20                  25                  30          


Ser Pro Leu Thr Phe Ser Pro Ala Gln Leu Thr Val Leu Glu Gly Glu 
        35                  40                  45              


Asn Ala Thr Phe Val Cys His Leu Pro Asp Val Pro Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Val Ser Pro Arg Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Gln Glu Asn His Thr Glu Pro Gly Lys Asp Arg Arg Phe Arg 
                85                  90                  95      


Val Thr Arg Leu Pro Ser Gly Gln Asp Phe His Thr Thr Ile Leu Ala 
            100                 105                 110         


Ala Gln Leu Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Asn Thr Gln Ile Tyr Glu Ser Pro Arg Ala Glu Leu Thr Val 
    130                 135                 140                 


Lys Glu Arg Val Leu Glu Pro Pro Thr Glu Ser Pro Ser Pro Pro Pro 
145                 150                 155                 160 


Arg Leu Thr Gly Gln Gly Gln Gly Leu Val Val Gly Val Thr Ser Val 
                165                 170                 175     


Leu Val Gly Val Leu Leu Leu Leu Leu Leu Thr Trp Val Leu Ala Ala 
            180                 185                 190         


Ala Phe Pro Arg Ala Thr Arg Gly Ala Cys Ala Cys Gly Ser Glu Asp 
        195                 200                 205             


Glu Pro Leu Lys Glu Gly Pro Ser Ala Ala Pro Val Phe Thr Val Asp 
    210                 215                 220                 


Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro 
225                 230                 235                 240 


Ala Pro Cys Ala Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro 
                245                 250                 255     


Ser Arg Pro Gly Ser Pro Gly Pro Leu Pro Leu Arg Pro Glu Asp Gly 
            260                 265                 270         


Pro Cys Pro Trp Pro Leu 
        275             


<210>  12
<211>  282
<212>  PRT
<213>  Bos taurus

<400>  12

Met Gly Thr Pro Arg Ala Leu Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Cys Trp Pro Gly Trp Leu Leu Glu Ala Ser Ser Arg Pro Trp 
            20                  25                  30          


Ser Ala Leu Thr Phe Ser Pro Pro Arg Leu Val Val Pro Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Ser Lys Pro Glu Arg Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Lys Ser Pro Ser Asn Gln Met Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Ser Arg Asp Arg Arg Phe Arg 
                85                  90                  95      


Val Thr Pro Leu Pro Asp Gly Gln Gln Phe Asn Met Ser Ile Val Ala 
            100                 105                 110         


Ala Gln Arg Asn Asp Ser Gly Val Tyr Phe Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Arg Thr Gln Ile Asn Glu Ser His Ser Ala Glu Leu Met Val 
    130                 135                 140                 


Thr Glu Ala Val Leu Glu Pro Pro Thr Glu Pro Pro Ser Pro Gln Pro 
145                 150                 155                 160 


Arg Pro Glu Gly Gln Met Gln Ser Leu Val Ile Gly Val Thr Ser Val 
                165                 170                 175     


Leu Leu Gly Val Leu Leu Leu Pro Pro Leu Ile Trp Val Leu Ala Ala 
            180                 185                 190         


Val Phe Leu Arg Ala Thr Arg Gly Gly Cys Ala Arg Arg Ser Gln Asp 
        195                 200                 205             


Gln Pro Pro Lys Glu Gly Cys Pro Ser Val Pro Ala Val Thr Val Asp 
    210                 215                 220                 


Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Ala 
225                 230                 235                 240 


Ala Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro 
                245                 250                 255     


Gly Arg Arg Ala Ser Ala Asp Ser Pro Gln Gly Pro Trp Pro Leu Arg 
            260                 265                 270         


Thr Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280         


<210>  13
<211>  282
<212>  PRT
<213>  Bos taurus

<400>  13

Met Gly Thr Pro Arg Ala Leu Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Cys Trp Pro Gly Trp Leu Leu Glu Ala Ser Ser Arg Pro Trp 
            20                  25                  30          


Ser Ala Leu Thr Phe Ser Pro Pro Arg Leu Val Val Pro Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Ser Lys Pro Glu Arg Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Lys Ser Pro Ser Asn Gln Met Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Ser Arg Asp Arg Arg Phe Arg 
                85                  90                  95      


Val Thr Pro Leu Pro Asp Gly Gln Gln Phe Asn Met Ser Ile Val Ala 
            100                 105                 110         


Ala Gln Arg Asn Asp Ser Gly Val Tyr Phe Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Arg Thr Gln Ile Asn Glu Ser His Ser Ala Glu Leu Met Val 
    130                 135                 140                 


Thr Glu Ala Val Leu Glu Pro Pro Thr Glu Pro Pro Ser Pro Gln Pro 
145                 150                 155                 160 


Arg Pro Glu Gly Gln Met Gln Ser Leu Val Ile Gly Val Thr Ser Val 
                165                 170                 175     


Leu Leu Gly Val Leu Leu Leu Pro Pro Leu Ile Trp Val Leu Ala Ala 
            180                 185                 190         


Val Phe Leu Arg Ala Thr Arg Gly Gly Cys Ala Arg Arg Ser Gln Asp 
        195                 200                 205             


Gln Pro Pro Lys Glu Gly Cys Pro Ser Val Pro Ala Val Thr Val Asp 
    210                 215                 220                 


Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Ala 
225                 230                 235                 240 


Ala Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro 
                245                 250                 255     


Gly Arg Arg Ala Ser Ala Asp Ser Pro Gln Gly Pro Trp Pro Leu Arg 
            260                 265                 270         


Thr Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280         


<210>  14
<211>  282
<212>  PRT
<213>  Bos taurus

<400>  14

Met Gly Thr Pro Arg Ala Leu Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Cys Trp Pro Gly Trp Leu Leu Glu Ala Ser Ser Arg Pro Trp 
            20                  25                  30          


Ser Ala Leu Thr Phe Ser Pro Pro Arg Leu Val Val Pro Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Ser Lys Pro Glu Arg Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Lys Ser Pro Ser Asn Gln Met Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Ser Arg Asp Arg Arg Phe Arg 
                85                  90                  95      


Val Thr Pro Leu Pro Asp Gly Gln Gln Phe Asn Met Ser Ile Val Ala 
            100                 105                 110         


Ala Gln Arg Asn Asp Ser Gly Val Tyr Phe Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Arg Thr Gln Ile Asn Glu Ser His Ser Ala Glu Leu Met Val 
    130                 135                 140                 


Thr Glu Ala Val Leu Glu Pro Pro Thr Glu Pro Pro Ser Pro Gln Pro 
145                 150                 155                 160 


Arg Pro Glu Gly Gln Met Gln Ser Leu Val Ile Gly Val Thr Ser Val 
                165                 170                 175     


Leu Leu Gly Val Leu Leu Leu Pro Pro Leu Ile Trp Val Leu Ala Ala 
            180                 185                 190         


Val Phe Leu Arg Ala Thr Arg Gly Gly Cys Ala Arg Arg Ser Gln Asp 
        195                 200                 205             


Gln Pro Pro Lys Glu Gly Cys Pro Ser Val Pro Ala Val Thr Val Asp 
    210                 215                 220                 


Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Ala 
225                 230                 235                 240 


Ala Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro 
                245                 250                 255     


Gly Arg Arg Ala Ser Ala Asp Ser Pro Gln Gly Pro Trp Pro Leu Arg 
            260                 265                 270         


Thr Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280         


<210>  15
<211>  288
<212>  PRT
<213>  Sus scrofa

<400>  15

Met Gly Thr Pro Arg Ala Leu Trp Pro Val Val Trp Val Val Leu Gln 
1               5                   10                  15      


Leu Arg Trp Trp Pro Gly Trp Leu Leu Asp Ala Pro Ser Arg Pro Arg 
            20                  25                  30          


Gly Pro Leu Thr Leu Ser Pro Ala Gln Leu Thr Val Pro Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Pro Ser Glu Pro Lys His Phe Ile 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Ser Glu Asp Gly Ser Gln Pro Gly Arg Asp Pro Arg Phe His 
                85                  90                  95      


Val Thr Pro Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Ala 
            100                 105                 110         


Thr Arg Arg Asn Asp Ser Gly Thr Tyr Phe Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Lys Thr Gln Ile Asn Glu Ser His Gln Ala Lys Leu Thr Val 
    130                 135                 140                 


Thr Glu Arg Val Leu Glu Leu Pro Thr Glu His Pro Ser Cys Pro Pro 
145                 150                 155                 160 


Arg Pro Glu Gly His Leu Glu Gly Gln Val Leu Val Ile Thr Ser Val 
                165                 170                 175     


Leu Leu Gly Leu Leu Leu Leu Leu Leu Leu Ala Trp Ser Leu Ala Ala 
            180                 185                 190         


Phe Phe Leu Trp Ala Pro Arg Gly Asp Arg Ala His Arg Thr Glu Asn 
        195                 200                 205             


Gln Pro Arg Lys Glu Gly Ala Ser Ser Gly Leu Val Phe Thr Val Asp 
    210                 215                 220                 


Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Val Pro Ser 
225                 230                 235                 240 


Ala Ala Cys Val Ser Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro 
                245                 250                 255     


Glu Arg Pro Gly Ser Pro Gly Arg Arg Ala Ser Ala Asp Ser Pro Gln 
            260                 265                 270         


Gly Pro Trp Pro Gln Arg Thr Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  16
<211>  287
<212>  PRT
<213>  Sus scrofa

<400>  16

Met Gly Thr Pro Arg Ala Leu Trp Pro Val Val Trp Val Val Leu Gln 
1               5                   10                  15      


Leu Arg Trp Trp Pro Gly Trp Leu Leu Asp Ala Pro Ser Arg Pro Arg 
            20                  25                  30          


Gly Pro Leu Thr Leu Ser Pro Ala Gln Leu Thr Val Pro Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Pro Ser Glu Pro Lys His Phe Ile 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Ser Glu Glu Gly Ser Gln Pro Gly Arg Asp Pro Arg Phe His 
                85                  90                  95      


Val Thr Pro Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Ala 
            100                 105                 110         


Thr Arg Arg Asn Asp Ser Gly Thr Tyr Phe Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Lys Thr Gln Ile Asn Glu Ser His Gln Ala Lys Leu Thr Val 
    130                 135                 140                 


Thr Glu Arg Val Leu Glu Leu Pro Thr Glu His Pro Ser Cys Pro Pro 
145                 150                 155                 160 


Arg Pro Glu Gly His Leu Glu Gly Gln Val Leu Val Ile Thr Ser Val 
                165                 170                 175     


Leu Leu Gly Leu Leu Leu Leu Leu Leu Leu Ala Trp Ser Leu Ala Ala 
            180                 185                 190         


Phe Phe Leu Trp Ala Pro Arg Gly Asp Arg Ala His Arg Arg Glu Asn 
        195                 200                 205             


Gln Pro Arg Glu Gly Ala Ser Ser Gly Leu Val Phe Thr Val Asp Tyr 
    210                 215                 220                 


Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Val Pro Ser Ala 
225                 230                 235                 240 


Ala Cys Val Ser Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Glu 
                245                 250                 255     


Arg Pro Gly Ser Pro Gly Arg Arg Ala Ser Ala Asp Ser Pro Gln Gly 
            260                 265                 270         


Pro Trp Pro Gln Arg Thr Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285         


<210>  17
<211>  284
<212>  PRT
<213>  Ovis aries

<400>  17

Met Gly Thr Pro Arg Ala Pro Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Cys Trp Pro Gly Trp Leu Leu Glu Ala Ser Ser Arg Pro Trp 
            20                  25                  30          


Ser Ala Leu Thr Phe Ser Pro Ala Arg Leu Val Val Pro Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Ser Lys Pro Glu Glu His Phe 
    50                  55                  60                  


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
65                  70                  75                  80  


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Arg Asp Arg Arg Phe 
                85                  90                  95      


Arg Val Thr Pro Leu Pro Gly Gly Gln Gln Phe His Met Ser Ile Val 
            100                 105                 110         


Ala Ala Gln Arg Asn Asp Ser Gly Ala Tyr Phe Cys Gly Ala Ile Tyr 
        115                 120                 125             


Leu Pro Pro Arg Thr Gln Ile Asn Glu Ser His Pro Ala Glu Leu Arg 
    130                 135                 140                 


Val Thr Glu Gly Val Leu Glu Pro Pro Thr Glu His Pro Ser Pro Gln 
145                 150                 155                 160 


Pro Arg Pro Glu Gly Gln Met Gln Ser Leu Val Ile Gly Val Thr Ser 
                165                 170                 175     


Phe Ile Leu Gly Val Leu Leu Leu Leu Leu Leu Ile Trp Val Leu Ala 
            180                 185                 190         


Ala Val Phe Leu Gly Ala Thr Arg Gly Asp Gly Ser Pro Lys Ala Leu 
        195                 200                 205             


Pro Leu Ala Pro Ser Leu Ala Ser Cys Pro Asn Pro Ile Pro Ser Val 
    210                 215                 220                 


Ser Pro Ile Arg Glu Asp Leu Asp Trp Ala Ser Arg Ala Gly Gly Pro 
225                 230                 235                 240 


Leu Gly Asn Pro Ser Ala Gly Pro Ala Leu Gly Glu Arg Gly Arg Glu 
                245                 250                 255     


Asp Gly Pro Asp His Gly Arg His Pro Gly Trp Thr Ser Ala Arg Ala 
            260                 265                 270         


Leu Ser Ser Cys Asn Ser Gln Gly Thr Glu Leu Leu 
        275                 280                 


<210>  18
<211>  283
<212>  PRT
<213>  Capra hircus

<400>  18

Met Gly Thr Pro Arg Ala Pro Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Cys Trp Pro Gly Trp Leu Leu Glu Ala Ser Ser Arg Pro Trp 
            20                  25                  30          


Ser Ala Leu Thr Phe Ser Pro Ala Arg Leu Val Val Ser Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Ser Lys Pro Glu Glu His Phe 
    50                  55                  60                  


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
65                  70                  75                  80  


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Arg Gly Arg Arg Phe 
                85                  90                  95      


Arg Val Thr Pro Leu Pro Gly Gly Arg Gln Phe His Met Ser Ile Val 
            100                 105                 110         


Ala Ala Gln Arg Asp Asp Ser Gly Ala Tyr Phe Cys Gly Ala Ile Tyr 
        115                 120                 125             


Leu Pro Pro Arg Thr Gln Ile Asn Glu Ser Arg Pro Ala Glu Leu Arg 
    130                 135                 140                 


Val Thr Glu Glu Val Leu Glu Pro Pro Thr Glu His Pro Ser Pro Gln 
145                 150                 155                 160 


Pro Arg Pro Glu Gly Gln Met Gln Ser Leu Val Ile Gly Val Thr Ser 
                165                 170                 175     


Phe Ile Leu Gly Val Leu Leu Leu Leu Leu Leu Ile Trp Val Leu Ala 
            180                 185                 190         


Ala Ala Phe Leu Gly Ala Thr Arg Gly Gly Cys Ala Cys Arg Ser Arg 
        195                 200                 205             


Asp Gln Leu Pro Lys Glu Gly Ser Pro Ser Val Pro Ala Val Thr Val 
    210                 215                 220                 


Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro 
225                 230                 235                 240 


Ala Ala Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe 
                245                 250                 255     


Pro Gly Arg Arg Ala Ser Ala Asp Ser Pro Gln Gly Pro Trp Pro Leu 
            260                 265                 270         


Arg Thr Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280             


<210>  19
<211>  282
<212>  PRT
<213>  Capra hircus

<400>  19

Met Gly Thr Pro Arg Ala Pro Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Cys Trp Pro Gly Trp Leu Leu Glu Ala Ser Ser Arg Pro Trp 
            20                  25                  30          


Ser Ala Leu Thr Phe Ser Pro Ala Arg Leu Val Val Ser Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Ser Lys Pro Glu Glu His Phe 
    50                  55                  60                  


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
65                  70                  75                  80  


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Arg Gly Arg Arg Phe 
                85                  90                  95      


Arg Val Thr Pro Leu Pro Gly Gly Arg Gln Phe His Met Ser Ile Val 
            100                 105                 110         


Ala Ala Gln Arg Asp Asp Ser Gly Ala Tyr Phe Cys Gly Ala Ile Tyr 
        115                 120                 125             


Leu Pro Pro Arg Thr Gln Ile Asn Glu Ser Arg Pro Ala Glu Leu Arg 
    130                 135                 140                 


Val Thr Glu Glu Val Leu Glu Pro Pro Thr Glu His Pro Ser Pro Gln 
145                 150                 155                 160 


Pro Arg Pro Glu Gly Gln Met Gln Ser Leu Val Ile Gly Val Thr Ser 
                165                 170                 175     


Phe Ile Leu Gly Val Leu Leu Leu Leu Leu Leu Ile Trp Val Leu Ala 
            180                 185                 190         


Ala Ala Phe Leu Gly Ala Thr Arg Gly Gly Cys Ala Cys Arg Ser Arg 
        195                 200                 205             


Asp Gln Leu Pro Glu Gly Ser Pro Ser Val Pro Ala Val Thr Val Asp 
    210                 215                 220                 


Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Ala 
225                 230                 235                 240 


Ala Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro 
                245                 250                 255     


Gly Arg Arg Ala Ser Ala Asp Ser Pro Gln Gly Pro Trp Pro Leu Arg 
            260                 265                 270         


Thr Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280         


<210>  20
<211>  290
<212>  PRT
<213>  Camelus bactrianus

<400>  20

Met Gly Thr Pro Gln Ala Leu Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Leu Leu Asp Ser Pro Ser Arg Pro Trp 
            20                  25                  30          


Ser Pro Leu Thr Phe Ser Pro Ala Arg Leu Thr Val Pro Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Ser Lys Pro Glu His Phe Leu 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Ala Arg Asp Arg Arg Phe Arg 
                85                  90                  95      


Val Thr Pro Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Ile Ala 
            100                 105                 110         


Ala Gln Arg Asn Asp Ser Gly Val Tyr Phe Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Lys Thr Gln Ile Asn Glu Ser His Pro Ala Glu Leu Thr Val 
    130                 135                 140                 


Thr Glu Arg Val Leu Glu Leu Ser Pro Thr Glu Arg Pro Ser Ser Pro 
145                 150                 155                 160 


Pro Arg Thr Glu Gly Gln Leu Gln Gly Leu Val Ile Gly Ile Thr Ser 
                165                 170                 175     


Val Leu Leu Gly Val Leu Leu Leu Leu Leu Leu Ile Trp Val Leu Ala 
            180                 185                 190         


Ala Val Phe Leu Gly Ala Thr Arg Gly Ala Cys Thr Arg Arg Ser Glu 
        195                 200                 205             


Asp Ser Glu Pro Arg Lys Glu Gly Ser Thr Ala Ala Pro Val Phe Thr 
    210                 215                 220                 


Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu 
225                 230                 235                 240 


Pro Ser Ala Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val 
                245                 250                 255     


Phe Pro Gly Arg Pro Gly Ser Pro Gly Arg Arg Ala Ser Ala Asp Ser 
            260                 265                 270         


Leu Gln Gly Pro Arg Ser Leu Arg Thr Glu Asp Gly His Cys Ser Trp 
        275                 280                 285             


Pro Leu 
    290 


<210>  21
<211>  289
<212>  PRT
<213>  Camelus bactrianus

<400>  21

Met Gly Thr Pro Gln Ala Leu Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Leu Leu Asp Ser Pro Ser Arg Pro Trp 
            20                  25                  30          


Ser Pro Leu Thr Phe Ser Pro Ala Arg Leu Thr Val Pro Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Ser Lys Pro Glu His Phe Leu 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Ala Arg Asp Arg Arg Phe Arg 
                85                  90                  95      


Val Thr Pro Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Ile Ala 
            100                 105                 110         


Ala Gln Arg Asn Asp Ser Gly Val Tyr Phe Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Lys Thr Gln Ile Asn Glu Ser His Pro Ala Glu Leu Thr Val 
    130                 135                 140                 


Thr Glu Arg Val Leu Glu Leu Ser Pro Thr Glu Arg Pro Ser Ser Pro 
145                 150                 155                 160 


Pro Arg Thr Glu Gly Gln Leu Gln Gly Leu Val Ile Gly Ile Thr Ser 
                165                 170                 175     


Val Leu Leu Gly Val Leu Leu Leu Leu Leu Leu Ile Trp Val Leu Ala 
            180                 185                 190         


Ala Val Phe Leu Gly Ala Thr Arg Gly Ala Cys Thr Arg Arg Ser Glu 
        195                 200                 205             


Asp Ser Glu Pro Arg Glu Gly Ser Thr Ala Ala Pro Val Phe Thr Val 
    210                 215                 220                 


Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro 
225                 230                 235                 240 


Ser Ala Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe 
                245                 250                 255     


Pro Gly Arg Pro Gly Ser Pro Gly Arg Arg Ala Ser Ala Asp Ser Leu 
            260                 265                 270         


Gln Gly Pro Arg Ser Leu Arg Thr Glu Asp Gly His Cys Ser Trp Pro 
        275                 280                 285             


Leu 
    


<210>  22
<211>  290
<212>  PRT
<213>  Camelus ferus

<400>  22

Met Gly Thr Pro Gln Ala Leu Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Leu Leu Asp Ser Pro Ser Arg Pro Trp 
            20                  25                  30          


Ser Pro Leu Thr Phe Ser Pro Ala Arg Leu Thr Val Pro Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Ser Lys Pro Glu His Phe Leu 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Ala Arg Asp Arg Arg Phe Arg 
                85                  90                  95      


Val Thr Pro Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Ile Ala 
            100                 105                 110         


Ala Gln Arg Asn Asp Ser Gly Val Tyr Phe Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Lys Thr Gln Ile Asn Glu Ser His Pro Ala Glu Leu Thr Val 
    130                 135                 140                 


Thr Glu Arg Val Leu Glu Leu Ser Pro Thr Glu Arg Pro Ser Ser Pro 
145                 150                 155                 160 


Pro Arg Thr Glu Gly Gln Leu Gln Gly Leu Val Ile Gly Ile Thr Ser 
                165                 170                 175     


Val Leu Leu Gly Val Leu Leu Leu Leu Leu Leu Ile Trp Val Leu Ala 
            180                 185                 190         


Ala Val Phe Leu Gly Ala Thr Arg Gly Ala Cys Thr Arg Arg Ser Glu 
        195                 200                 205             


Asp Ser Glu Pro Arg Lys Glu Gly Ser Thr Ala Ala Pro Val Phe Thr 
    210                 215                 220                 


Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu 
225                 230                 235                 240 


Pro Ser Ala Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val 
                245                 250                 255     


Phe Pro Gly Arg Pro Gly Ser Pro Gly Arg Arg Ala Ser Ala Asp Ser 
            260                 265                 270         


Leu Gln Gly Pro Arg Ser Leu Arg Thr Glu Asp Gly His Cys Ser Trp 
        275                 280                 285             


Pro Leu 
    290 


<210>  23
<211>  289
<212>  PRT
<213>  Camelus ferus

<400>  23

Met Gly Thr Pro Gln Ala Leu Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Leu Leu Asp Ser Pro Ser Arg Pro Trp 
            20                  25                  30          


Ser Pro Leu Thr Phe Ser Pro Ala Arg Leu Thr Val Pro Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Ser Lys Pro Glu His Phe Leu 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Ala Arg Asp Arg Arg Phe Arg 
                85                  90                  95      


Val Thr Pro Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Ile Ala 
            100                 105                 110         


Ala Gln Arg Asn Asp Ser Gly Val Tyr Phe Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Lys Thr Gln Ile Asn Glu Ser His Pro Ala Glu Leu Thr Val 
    130                 135                 140                 


Thr Glu Arg Val Leu Glu Leu Ser Pro Thr Glu Arg Pro Ser Ser Pro 
145                 150                 155                 160 


Pro Arg Thr Glu Gly Gln Leu Gln Gly Leu Val Ile Gly Ile Thr Ser 
                165                 170                 175     


Val Leu Leu Gly Val Leu Leu Leu Leu Leu Leu Ile Trp Val Leu Ala 
            180                 185                 190         


Ala Val Phe Leu Gly Ala Thr Arg Gly Ala Cys Thr Arg Arg Ser Glu 
        195                 200                 205             


Asp Ser Glu Pro Arg Glu Gly Ser Thr Ala Ala Pro Val Phe Thr Val 
    210                 215                 220                 


Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro 
225                 230                 235                 240 


Ser Ala Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe 
                245                 250                 255     


Pro Gly Arg Pro Gly Ser Pro Gly Arg Arg Ala Ser Ala Asp Ser Leu 
            260                 265                 270         


Gln Gly Pro Arg Ser Leu Arg Thr Glu Asp Gly His Cys Ser Trp Pro 
        275                 280                 285             


Leu 
    


<210>  24
<211>  290
<212>  PRT
<213>  Camelus dromedarius

<400>  24

Met Gly Thr Pro Gln Ala Leu Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Leu Leu Asp Ser Pro Ser Arg Pro Trp 
            20                  25                  30          


Ser Pro Leu Thr Phe Ser Pro Ala Arg Leu Thr Val Pro Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Ser Lys Pro Glu His Phe Leu 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Ala Arg Asp Arg Arg Phe Arg 
                85                  90                  95      


Val Thr Pro Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Ile Ala 
            100                 105                 110         


Ala Gln Arg Asn Asp Ser Gly Val Tyr Phe Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Lys Thr Gln Ile Asn Glu Ser His Pro Ala Glu Leu Thr Val 
    130                 135                 140                 


Thr Glu Arg Val Leu Glu Leu Ser Pro Thr Glu Arg Pro Ser Ser Pro 
145                 150                 155                 160 


Pro Arg Thr Glu Gly Gln Leu Gln Gly Leu Val Ile Gly Ile Thr Ser 
                165                 170                 175     


Val Leu Leu Gly Val Leu Leu Leu Leu Leu Leu Ile Trp Val Leu Ala 
            180                 185                 190         


Ala Val Phe Leu Gly Ala Thr Arg Gly Ala Cys Thr Arg Arg Ser Glu 
        195                 200                 205             


Asp Ser Glu Pro Arg Glu Gly Ser Thr Ala Ala Pro Val Phe Thr Val 
    210                 215                 220                 


Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro 
225                 230                 235                 240 


Ser Ala Pro Cys Val Pro Glu Gln Thr Glu Glu Tyr Ala Thr Ile Val 
                245                 250                 255     


Phe Pro Gly Arg Pro Gly Ser Pro Gly Arg Arg Ala Ser Ala Asp Ser 
            260                 265                 270         


Leu Gln Gly Pro Arg Ser Leu Arg Thr Glu Asp Gly His Cys Ser Trp 
        275                 280                 285             


Pro Leu 
    290 


<210>  25
<211>  289
<212>  PRT
<213>  Camelus dromedarius

<400>  25

Met Gly Thr Pro Gln Ala Leu Trp Pro Leu Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Leu Leu Asp Ser Pro Ser Arg Pro Trp 
            20                  25                  30          


Ser Pro Leu Thr Phe Ser Pro Ala Arg Leu Thr Val Pro Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Ser Lys Pro Glu His Phe Leu 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Ala Arg Asp Arg Arg Phe Arg 
                85                  90                  95      


Val Thr Pro Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Ile Ala 
            100                 105                 110         


Ala Gln Arg Asn Asp Ser Gly Val Tyr Phe Cys Gly Ala Ile Tyr Leu 
        115                 120                 125             


Pro Pro Lys Thr Gln Ile Asn Glu Ser His Pro Ala Glu Leu Thr Val 
    130                 135                 140                 


Thr Glu Arg Val Leu Glu Leu Ser Pro Thr Glu Arg Pro Ser Ser Pro 
145                 150                 155                 160 


Pro Arg Thr Glu Gly Gln Leu Gln Gly Leu Val Ile Gly Ile Thr Ser 
                165                 170                 175     


Val Leu Leu Gly Val Leu Leu Leu Leu Leu Leu Ile Trp Val Leu Ala 
            180                 185                 190         


Ala Val Phe Leu Gly Ala Thr Arg Gly Ala Cys Thr Arg Arg Ser Glu 
        195                 200                 205             


Asp Ser Glu Pro Arg Glu Gly Ser Thr Ala Ala Pro Val Phe Thr Val 
    210                 215                 220                 


Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro 
225                 230                 235                 240 


Ser Ala Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe 
                245                 250                 255     


Pro Gly Arg Pro Gly Ser Pro Gly Arg Arg Ala Ser Ala Asp Ser Leu 
            260                 265                 270         


Gln Gly Pro Arg Ser Leu Arg Thr Glu Asp Gly His Cys Ser Trp Pro 
        275                 280                 285             


Leu 
    


<210>  26
<211>  16
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  26

Ser Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Cys 
1               5                   10                  15      


<210>  27
<211>  16
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Immnogenic polypeptide

<400>  27

Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Cys 
1               5                   10                  15      


<210>  28
<211>  16
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  28

Cys Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
1               5                   10                  15      


<210>  29
<211>  17
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  29

Cys Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser 
1               5                   10                  15      


Val 
    


<210>  30
<211>  17
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  30

Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val 
1               5                   10                  15      


Cys 
    


<210>  31
<211>  16
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  31

Cys Gln Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Lys 
1               5                   10                  15      


<210>  32
<211>  15
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  32

Gln Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Lys Cys 
1               5                   10                  15  


<210>  33
<211>  16
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  33

Cys Gln Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Lys 
1               5                   10                  15      


<210>  34
<211>  16
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  34

Gln Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Lys Cys 
1               5                   10                  15      


<210>  35
<211>  19
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  35

Cys Gln Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met 
1               5                   10                  15      


Ser Val Lys 
            


<210>  36
<211>  19
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  36

Gln Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser 
1               5                   10                  15      


Val Lys Cys 
            


<210>  37
<211>  16
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Norleucine (Nle)

<400>  37

Cys Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Cys Xaa Cys 
1               5                   10                  15      


<210>  38
<211>  17
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Norleucine (Nle)

<400>  38

Cys Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Cys Xaa 
1               5                   10                  15      


Cys 
    


<210>  39
<211>  20
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne


<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Norleucine (Nle)

<400>  39

Cys Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser 
1               5                   10                  15      


Val Cys Xaa Cys 
            20  


<210>  40
<211>  19
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Norleucine (Nle)

<400>  40

Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Cys Gly 
1               5                   10                  15      


Xaa Glu Cys 
            


<210>  41
<211>  18
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Norleucine (Nle)

<400>  41

Cys Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Cys Gly Xaa Glu 
1               5                   10                  15      


Glu Cys 
        


<210>  42
<211>  21
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne


<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Norleucine (Nle)

<400>  42

Cys Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Cys 
1               5                   10                  15      


Gly Glu Xaa Glu Cys 
            20      


<210>  43
<211>  21
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne


<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Norleucine (Nle)

<400>  43

Cys Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Cys 
1               5                   10                  15      


Glu Glu Xaa Gly Cys 
            20      


<210>  44
<211>  14
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  44

Cys Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Glu 
1               5                   10                  


<210>  45
<211>  14
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  45

Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Glu Cys 
1               5                   10                  


<210>  46
<211>  14
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  46

Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Glu Cys 
1               5                   10                  


<210>  47
<211>  16
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  47

Gln Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Glu Lys Cys 
1               5                   10                  15      


<210>  48
<211>  16
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne

<400>  48

Cys Gln Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Glu Lys 
1               5                   10                  15      


<210>  49
<211>  18
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Polypeptide immunogne


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Norleucine (Nle)

<400>  49

Cys Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Cys Glu Xaa 
1               5                   10                  15      


Glu Cys 
        


<210>  50
<211>  14
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Fragment de PD-1

<400>  50

Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
1               5                   10                  


<210>  51
<211>  13
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Fragment de PD-1

<400>  51

Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu 
1               5                   10              


<210>  52
<211>  12
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Fragment de PD-1

<400>  52

Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu 
1               5                   10          


<210>  53
<211>  13
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Fragment de PD-1

<400>  53

Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
1               5                   10              


<210>  54
<211>  11
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Fragment de PD-1

<400>  54

Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
1               5                   10      


<210>  55
<211>  15
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Fragment de PD-1

<400>  55

Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
1               5                   10                  15  


<210>  56
<211>  13
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Fragment de PD-1

<400>  56

Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
1               5                   10              


<210>  57
<211>  14
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Fragment de PD-1

<400>  57

Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
1               5                   10                  


<210>  58
<211>  14
<212>  PRT
<213>  Squence artificielle

<220>
<223>  Fragment de PD-1

<400>  58

Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser 
1               5                   10                  


