                         SEQUENCE LISTING

<110>  ULTRAHUMAN NINE LIMITED
 
<120>  PD1 BINDING AGENTS

<130>  ULNL-001/00WO 332952-2003

<150>  GB 1813405.6
<151>  2018-08-16

<150>  GB 1803746.5
<151>  2018-03-08

<160>  416   

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody MH8 heavy chain variable (VH) region

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Trp Gln Asp Gly Ser Thr Lys Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Arg Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody MH8 light chain variable (VL) region

<400>  2

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Thr Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Tyr Ala Tyr His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody MH4 heavy chain variable (VH) region

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Gln Asp Gly Ser Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Arg Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody MH4 light chain variable (VL) region

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Thr Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Tyr Ala Tyr His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody MH12 heavy chain variable (VH) region

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Trp Gln Asp Gly Ser Glu Lys Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Arg Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  6
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody MH12 light chain variable (VL) region

<400>  6

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Thr Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Tyr Ala Tyr His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  7
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody 09C06 heavy chain variable (VH) region

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Trp Gln Asp Gly Ser Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Arg Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Antibody 09C06 light chain variable (VL) region

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Tyr Ala Ser His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  10
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  11
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  12
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  13
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  14
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  15
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                245                 250                 255     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            260                 265                 270         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        275                 280                 285             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    290                 295                 300                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
305                 310                 315                 320 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 


<210>  16
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  17
<211>  288
<212>  PRT
<213>  Macaca fascicularis

<400>  17

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Glu Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Ala Pro Thr Phe Ser Pro Ala Leu Leu Leu Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Ala Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Arg Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Ala Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Gln Gly Thr Ile Glu Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Ala Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Leu Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Pro Arg Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  18
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Asp Glu Leu Thr 
1               5   


<210>  19
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  19

Arg Glu Glu Met 
1               


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Thr or a conservative substitution of Thr

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Phe or a conservative substitution of Phe

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Ser or a conservative substitution of Ser

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Gly or any other amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Met or a conservative substitution of Met

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Ser or any other amino acid

<400>  20

Gly Phe Xaa Xaa Xaa Ser Tyr Xaa Xaa Xaa 
1               5                   10  


<210>  21
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Val or a conservative substitution of Val

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Ala or a conservative substitution of Ala

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Val or Asn

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Trp or Lys

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Gln or Ala

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Asp or Gly

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Thr or Glu

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Asn, Lys, or Ser

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is Asn or Val

<400>  21

Xaa Xaa Xaa Ile Xaa Xaa Xaa Gly Ser Xaa Xaa Tyr Xaa Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Ala or any other amino acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Tyr or a conservative substitution of Tyr

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Asn or any other amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Tyr or a conservative substitution of Tyr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Trp or any other amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Ile or any other amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Asp or a conservative substitution of Asp

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Val or any other amino acid

<400>  22

Xaa Xaa Gly Xaa Xaa Xaa Tyr Xaa Xaa Xaa 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  23

Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  24
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  24

Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  25
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  25

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR1


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Gln or Glu

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Ser or a conservative substitution of Ser

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Leu or a conservative substitution of Leu

<400>  26

Lys Ser Ser Xaa Ser Val Xaa Asn Asp Xaa Ala 
1               5                   10      


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR2


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Phe or any other amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is His or any other amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Ser or a conservative substitution of Ser

<400>  27

Tyr Ala Xaa Xaa Arg Phe Xaa 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Gln or any other amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Ala or any other amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Thr or any other amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Tyr or any other amino acid

<400>  28

Xaa Gln Xaa Tyr Ser Xaa Pro Xaa Thr 
1               5                   


<210>  29
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  29

Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  30
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  30

Lys Ser Ser Gln Glu Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  31

Tyr Ala Phe His Arg Phe Thr 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  32

His Gln Ala Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  33

Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser 
1               5                   10  


<210>  34
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  34

Val Ala Asn Ile Trp Gln Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  35

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Arg 
1               5                   10  


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR1

<400>  36

Lys Ser Ser Gln Ser Val Thr Asn Asp Val Ala 
1               5                   10      


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR2

<400>  37

Tyr Ala Tyr His Arg Phe Thr 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR3

<400>  38

His Gln Ala Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  39

Gly Phe Ser Leu Ser Ser Tyr Gly Met Ser 
1               5                   10  


<210>  40
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  40

Val Ala Val Ile Trp Gln Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  41
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  41

Val Ala Asn Ile Trp Gln Asp Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  42

Gly Phe Ser Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  43
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  43

Val Ala Asn Ile Trp Gln Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR1

<400>  44

Lys Ser Ser Gln Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR2

<400>  45

Tyr Ala Ser His Arg Phe Thr 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR3

<400>  46

His Gln Ala Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  47

Gly Phe Ser Phe Thr Ser Tyr Gly Met Ser 
1               5                   10  


<210>  48
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  48

Leu Ala Asn Ile Trp Gln Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  49

Gly Phe Thr Phe Ser Ser Tyr Gly Val His 
1               5                   10  


<210>  50
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  50

Val Gly Val Ile Trp Gln Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR1

<400>  51

Lys Ser Ser Gln Ser Val Ser Asn Asp Leu Ala 
1               5                   10      


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR3

<400>  52

Gln Gln Ala Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  53
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  53

Leu Ala Asn Ile Trp Gln Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  54

Gly Phe Thr Leu Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  55
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  55

Leu Ala Val Ile Trp Ala Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  56

Ala Tyr Gly Asn Tyr Met Tyr Ile Asp Val 
1               5                   10  


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  57

Gly Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  58
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  58

Val Gly Val Ile Lys Gln Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  59

Gly Phe Ser Phe Thr Ser Tyr Gly Met His 
1               5                   10  


<210>  60
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  60

Val Gly Val Ile Trp Gln Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  61

Gly Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Met or Val

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Ser or His

<400>  62

Gly Phe Thr Phe Ser Ser Tyr Gly Xaa Xaa 
1               5                   10  


<210>  63
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Val or Asn

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Trp or Lys

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Glu or Thr

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Asn or Lys

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is Val or Asn

<400>  63

Val Ala Xaa Ile Xaa Gln Asp Gly Ser Xaa Xaa Tyr Xaa Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Ala, Asp, Glu, Gly, His, Ile, Lys, Leu, Gln, 
       Ser, Val or Trp

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Tyr, Phe or Trp

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Asn, Ala, Glu, Phe, Gly, His, Ile, Gln, Arg, 
       Ser, Thr, Val, Trp or Tyr

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Tyr, Val or Trp

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Trp, Phe, His, Met, Pro, Gln, Ser or Val

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Ile, Leu, Met, Ser, Thr, Val or Tyr

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is Asp or Glu

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Val, Ala, Glu, Phe, Gly, His, Ile, Gln, Arg, 
       Ser, Thr, Trp or Tyr


<400>  64

Xaa Xaa Gly Xaa Xaa Xaa Tyr Xaa Xaa Xaa 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Ser or His

<400>  65

Gly Phe Thr Phe Ser Ser Tyr Gly Met Xaa 
1               5                   10  


<210>  66
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Val or Asn

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Glu or Thr

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Asn or Lys

<400>  66

Val Ala Xaa Ile Trp Gln Asp Gly Ser Xaa Xaa Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Ala or Gly

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Trp or Met

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Arg or Val

<400>  67

Xaa Tyr Gly Asn Tyr Xaa Tyr Ile Asp Xaa 
1               5                   10  


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR1


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Gln or Glu

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Ser, Gly or Thr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Leu or Val

<400>  68

Lys Ser Ser Xaa Ser Val Xaa Asn Asp Xaa Ala 
1               5                   10      


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR2


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Phe, Ser or Tyr

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is His, Pro or Thr

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Ser or Thr

<400>  69

Tyr Ala Xaa Xaa Arg Phe Xaa 
1               5           


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Gln or His

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Ala or Ser

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Thr, Asn or Ser

<400>  70

Xaa Gln Xaa Tyr Ser Xaa Pro Tyr Thr 
1               5                   


<210>  71
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR1


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Ser, Gly or Thr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is Leu or Val

<400>  71

Lys Ser Ser Gln Ser Val Xaa Asn Asp Xaa Ala 
1               5                   10      


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR2


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Ser or Tyr

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is Ser or Thr

<400>  72

Tyr Ala Xaa His Arg Phe Xaa 
1               5           


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Gln or His

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Thr or Ser

<400>  73

Xaa Gln Ala Tyr Ser Xaa Pro Tyr Thr 
1               5                   


<210>  74
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR1

<400>  74

Lys Ser Ser Gln Ser Val Gly Asn Asp Val Ala 
1               5                   10      


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR3

<400>  75

Gln Gln Ala Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR1

<400>  76

Lys Ser Ser Gln Ser Val Thr Asn Asp Leu Ala 
1               5                   10      


<210>  77
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR1

<400>  77

Lys Ser Ser Gln Ser Val Gly Asn Asp Leu Ala 
1               5                   10      


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR2

<400>  78

Tyr Ala Tyr His Arg Phe Ser 
1               5           


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR2

<400>  79

Tyr Ala Ser His Arg Phe Ser 
1               5           


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion partial HCDR2

<400>  80

Tyr Val Asp Ser Val Lys Gly 
1               5           


<210>  81
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  81

Val Lys Gly Arg Phe Thr Ile Ser Arg 
1               5                   


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  82

Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  83
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LAF sequence

<400>  83

Leu Thr Ser Tyr Gly Val His Trp Ile 
1               5                   


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  GE peptide


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is His or Ser

<400>  84

Tyr Gly Met Xaa Trp Val Arg Gln Ala 
1               5                   


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  TCED+ and LAF peptide

<400>  85

Tyr Trp Tyr Ile Asp Val Trp Gly Gln 
1               5                   


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HAF peptide

<400>  86

Leu Glu Trp Ile Gly Val Ile Tyr Ala 
1               5                   


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LAF peptide

<400>  87

Ile Gly Val Ile Tyr Ala Asp Gly Ser 
1               5                   


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HAF peptide

<400>  88

Leu Glu Trp Val Gly Val Ile Trp Gln 
1               5                   


<210>  89
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  89

Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  90
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  90

Ser Tyr Gly Val His 
1               5   


<210>  91
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  91

Gly Phe Ser Leu Thr Ser Tyr 
1               5           


<210>  92
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  92

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  93
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  93

Thr Ser Tyr Gly Val His 
1               5       


<210>  94
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  94

Leu Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu 
1               5                   10                  15      


Met Ser 
        


<210>  95
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  95

Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  96
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  96

Trp Ala Gly Gly Ser Thr 
1               5       


<210>  97
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  97

Ile Trp Ala Gly Gly Ser Thr Asn 
1               5               


<210>  98
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  98

Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15  


<210>  99
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  99

Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr 
1               5                   10  


<210>  100
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  100

Leu Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr 
1               5                   10          


<210>  101
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  101

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  102
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  102

Ala Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10          


<210>  103
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  103

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp 
1               5                   


<210>  104
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  104

Ala Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp 
1               5                   10      


<210>  105
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  105

Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  106
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  106

Gln Ser Val Ser Asn Asp 
1               5       


<210>  107
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  107

Ala Ser Gln Ser Val Ser Asn Asp 
1               5               


<210>  108
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  108

Ser Asn Asp Val Ala Trp Tyr 
1               5           


<210>  109
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  109

Tyr Ala Phe His Arg Phe Thr 
1               5           


<210>  110
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  110

Leu Leu Ile Tyr Tyr Ala Phe His Arg Phe 
1               5                   10  


<210>  111
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  111

His Gln Ala Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  112
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  112

Ala Tyr Ser Ser Pro Tyr 
1               5       


<210>  113
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  113

His Gln Ala Tyr Ser Ser Pro Tyr 
1               5               


<210>  114
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  114

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Lys 
1               5                   10                  15      


Asn Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Arg Ser Gln Val Phe Leu 
65                  70                  75                  80  


Arg Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  115
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hu317 VH IGHV4-4

<400>  115

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Ala Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  116
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VH GRAFT IGHV3-7

<400>  116

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  117
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  117

Asp Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Tyr Ala Phe His Arg Phe Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Ile Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys His Gln Ala Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
            100                 105         


<210>  118
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Hu317 VL IGKV4-1

<400>  118

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Tyr Ala Phe His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  119
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  VL GRAFT IGKV4-1

<400>  119

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Tyr Ala Phe His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  120

Gly Phe Asn Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  121

Gly Phe Ser Phe Ser Ser Tyr Gly Met Ser 
1               5                   10  


<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  122

Gly Phe Ser Phe Ser Ser Tyr Gly Val His 
1               5                   10  


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  123

Gly Phe Ser Phe Ser Ser Tyr Gly Val Ser 
1               5                   10  


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  124

Gly Phe Ser Phe Ser Ser Tyr Trp Met His 
1               5                   10  


<210>  125
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  125

Gly Phe Ser Phe Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  126
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  126

Gly Phe Ser Phe Thr Ser Tyr Gly Val Ser 
1               5                   10  


<210>  127
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  127

Gly Phe Ser Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  128

Gly Phe Ser Leu Ser Ser Tyr Gly Ile Ser 
1               5                   10  


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  129

Gly Phe Ser Leu Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  130

Gly Phe Ser Leu Ser Ser Tyr Gly Val His 
1               5                   10  


<210>  131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  131

Gly Phe Ser Leu Ser Ser Tyr Gly Val Ser 
1               5                   10  


<210>  132
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  132

Gly Phe Ser Leu Ser Ser Tyr Trp Met His 
1               5                   10  


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  133

Gly Phe Ser Leu Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  134
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  134

Gly Phe Thr Phe Ser Ser Tyr Gly Val Ser 
1               5                   10  


<210>  135
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  135

Gly Phe Thr Phe Thr Ser Tyr Gly Met His 
1               5                   10  


<210>  136
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  136

Gly Phe Thr Phe Thr Ser Tyr Gly Met Ser 
1               5                   10  


<210>  137
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  137

Gly Phe Thr Phe Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  138
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  138

Gly Phe Thr Phe Thr Ser Tyr Gly Val Ser 
1               5                   10  


<210>  139
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  139

Gly Phe Thr Leu Ser Ser Tyr Gly Met Ser 
1               5                   10  


<210>  140
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  140

Gly Phe Thr Leu Ser Ser Tyr Gly Val His 
1               5                   10  


<210>  141
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  141

Gly Phe Thr Leu Ser Ser Tyr Gly Val Ser 
1               5                   10  


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  142

Gly Phe Thr Leu Ser Ser Tyr Trp Met His 
1               5                   10  


<210>  143
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  143

Gly Phe Thr Leu Thr Ser Tyr Gly Met His 
1               5                   10  


<210>  144
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  144

Gly Phe Thr Leu Thr Ser Tyr Gly Met Ser 
1               5                   10  


<210>  145
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  145

Gly Phe Thr Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  146
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR1

<400>  146

Gly Phe Thr Leu Thr Ser Tyr Gly Val Ser 
1               5                   10  


<210>  147
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  147

Leu Ala Asn Ile Lys Ala Asp Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  148
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  148

Leu Ala Asn Ile Lys Ala Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  149
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  149

Leu Ala Asn Ile Lys Ala Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  150
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  150

Leu Ala Asn Ile Lys Ala Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  151
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  151

Leu Ala Asn Ile Lys Ala Gly Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  152
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  152

Leu Ala Asn Ile Lys Ala Gly Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  153
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  153

Leu Ala Asn Ile Lys Ala Gly Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  154
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  154

Leu Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  155
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  155

Leu Ala Asn Ile Lys Gln Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  156
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  156

Leu Ala Asn Ile Lys Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  157
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  157

Leu Ala Asn Ile Lys Gln Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  158
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  158

Leu Ala Asn Ile Trp Ala Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  159
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  159

Leu Ala Asn Ile Trp Ala Asp Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  160
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  160

Leu Ala Asn Ile Trp Ala Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  161
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  161

Leu Ala Asn Ile Trp Ala Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  162
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  162

Leu Ala Asn Ile Trp Ala Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  163
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  163

Leu Ala Asn Ile Trp Ala Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  164
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  164

Leu Ala Asn Ile Trp Ala Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  165
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  165

Leu Ala Asn Ile Trp Ala Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  166
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  166

Leu Ala Asn Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  167
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  167

Leu Ala Asn Ile Trp Gln Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  168
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  168

Leu Ala Asn Ile Trp Gln Asp Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  169
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  169

Leu Ala Asn Ile Trp Gln Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  170
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  170

Leu Ala Asn Ile Trp Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  171
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  171

Leu Ala Asn Ile Trp Gln Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  172
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  172

Leu Ala Asn Ile Trp Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  173
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  173

Leu Ala Asn Ile Trp Gln Gly Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  174
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  174

Leu Ala Val Ile Lys Ala Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  175
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  175

Leu Ala Val Ile Lys Ala Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  176
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  176

Leu Ala Val Ile Lys Ala Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  177
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  177

Leu Ala Val Ile Lys Ala Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  178
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  178

Leu Ala Val Ile Lys Ala Gly Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  179
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  179

Leu Ala Val Ile Lys Gln Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  180
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  180

Leu Ala Val Ile Lys Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  181
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  181

Leu Ala Val Ile Lys Gln Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  182
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  182

Leu Ala Val Ile Trp Ala Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  183
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  183

Leu Ala Val Ile Trp Ala Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  184
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  184

Leu Ala Val Ile Trp Ala Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  185
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  185

Leu Ala Val Ile Trp Ala Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  186
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  186

Leu Ala Val Ile Trp Ala Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  187
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  187

Leu Ala Val Ile Trp Ala Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  188
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  188

Leu Ala Val Ile Trp Ala Gly Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  189
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  189

Leu Ala Val Ile Trp Ala Gly Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  190
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  190

Leu Ala Val Ile Trp Ala Gly Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  191
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  191

Leu Ala Val Ile Trp Gln Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  192
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  192

Leu Ala Val Ile Trp Gln Asp Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  193
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  193

Leu Ala Val Ile Trp Gln Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  194
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  194

Leu Ala Val Ile Trp Gln Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  195
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  195

Leu Ala Val Ile Trp Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  196
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  196

Leu Ala Val Ile Trp Gln Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  197
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  197

Leu Ala Val Ile Trp Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  198
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  198

Leu Ala Val Ile Trp Gln Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  199
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  199

Leu Ala Val Ile Trp Gln Gly Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  200
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  200

Leu Ala Val Ile Trp Gln Gly Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  201
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  201

Leu Gly Asn Ile Lys Ala Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  202
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  202

Leu Gly Asn Ile Lys Ala Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  203
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  203

Leu Gly Asn Ile Lys Ala Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  204
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  204

Leu Gly Asn Ile Lys Ala Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  205
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  205

Leu Gly Asn Ile Lys Ala Gly Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  206
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  206

Leu Gly Asn Ile Lys Ala Gly Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  207
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  207

Leu Gly Asn Ile Lys Gln Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  208
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  208

Leu Gly Asn Ile Lys Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  209
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  209

Leu Gly Asn Ile Lys Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  210
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  210

Leu Gly Asn Ile Lys Gln Gly Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  211
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  211

Leu Gly Asn Ile Lys Gln Gly Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  212
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  212

Leu Gly Asn Ile Lys Gln Gly Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  213
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  213

Leu Gly Asn Ile Trp Ala Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  214
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  214

Leu Gly Asn Ile Trp Ala Asp Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  215
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  215

Leu Gly Asn Ile Trp Ala Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  216
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  216

Leu Gly Asn Ile Trp Ala Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  217
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  217

Leu Gly Asn Ile Trp Ala Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  218
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  218

Leu Gly Asn Ile Trp Ala Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  219
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  219

Leu Gly Asn Ile Trp Ala Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  220
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  220

Leu Gly Asn Ile Trp Ala Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  221
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  221

Leu Gly Asn Ile Trp Ala Gly Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  222
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  222

Leu Gly Asn Ile Trp Gln Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  223
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  223

Leu Gly Asn Ile Trp Gln Asp Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  224
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  224

Leu Gly Asn Ile Trp Gln Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  225
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  225

Leu Gly Asn Ile Trp Gln Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  226
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  226

Leu Gly Asn Ile Trp Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  227
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  227

Leu Gly Asn Ile Trp Gln Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  228
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  228

Leu Gly Asn Ile Trp Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  229
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  229

Leu Gly Asn Ile Trp Gln Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  230
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  230

Leu Gly Asn Ile Trp Gln Gly Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  231
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  231

Leu Gly Val Ile Lys Ala Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  232
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  232

Leu Gly Val Ile Lys Ala Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  233
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  233

Val Ala Asn Ile Trp Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  234
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  234

Leu Gly Val Ile Lys Ala Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  235
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  235

Leu Gly Val Ile Lys Gln Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  236
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  236

Leu Gly Val Ile Lys Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  237
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  237

Leu Gly Val Ile Lys Gln Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  238
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  238

Leu Gly Val Ile Lys Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  239
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  239

Leu Gly Val Ile Lys Gln Gly Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  240
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  240

Leu Gly Val Ile Trp Ala Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  241
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  241

Leu Gly Val Ile Trp Ala Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  242
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  242

Leu Gly Val Ile Trp Ala Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  243
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  243

Leu Gly Val Ile Trp Ala Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  244
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  244

Leu Gly Val Ile Trp Ala Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  245
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  245

Leu Gly Val Ile Trp Ala Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  246
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  246

Leu Gly Val Ile Trp Ala Asp Gly Ser Thr Ser Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  247
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  247

Leu Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  248
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  248

Leu Gly Val Ile Trp Pro Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  249
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  249

Leu Gly Val Ile Trp Gln Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  250
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  250

Leu Gly Val Ile Trp Gln Asp Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  251
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  251

Leu Gly Val Ile Trp Gln Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  252
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  252

Leu Gly Val Ile Trp Gln Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  253
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  253

Leu Gly Val Ile Trp Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  254
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  254

Leu Gly Val Ile Trp Gln Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  255
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  255

Leu Gly Val Ile Trp Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  256
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  256

Leu Gly Val Ile Trp Gln Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  257
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  257

Leu Gly Val Ile Trp Gln Gly Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  258
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  258

Leu Gly Val Ile Trp Gln Gly Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  259
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  259

Val Ala Asn Ile Lys Ala Asp Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  260
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  260

Val Ala Asn Ile Lys Ala Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  261
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  261

Val Ala Asn Ile Lys Ala Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  262
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  262

Val Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  263
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  263

Val Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  264
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  264

Val Ala Asn Ile Lys Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  265
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  265

Val Ala Asn Ile Lys Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  266
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  266

Val Ala Asn Ile Trp Ala Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  267
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  267

Val Ala Asn Ile Trp Ala Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  268
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  268

Val Ala Asn Ile Trp Ala Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  269
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  269

Val Ala Asn Ile Trp Ala Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  270
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  270

Val Ala Asn Ile Trp Ala Gly Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  271
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  271

Val Ala Asn Ile Trp Gln Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  272
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  272

Val Ala Asn Ile Trp Gln Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  273
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  273

Val Ala Asn Ile Trp Gln Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  274
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  274

Val Ala Asn Ile Trp Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  275
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  275

Val Ala Asn Ile Trp Gln Gly Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  276
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  276

Val Ala Asn Ile Trp Gln Gly Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  277
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  277

Val Ala Val Ile Lys Ala Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  278
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  278

Val Ala Val Ile Lys Gln Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  279
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  279

Val Ala Val Ile Lys Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  280
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  280

Val Ala Val Ile Lys Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  281
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  281

Val Ala Val Ile Lys Gln Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  282
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  282

Val Ala Val Ile Trp Ala Asp Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  283
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  283

Val Ala Val Ile Trp Ala Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  284
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  284

Val Ala Val Ile Trp Ala Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  285
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  285

Val Ala Val Ile Trp Ala Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  286
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  286

Val Ala Val Ile Trp Ala Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  287
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  287

Val Ala Val Ile Trp Gln Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  288
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  288

Val Ala Val Ile Trp Gln Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  289
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  289

Val Ala Val Ile Trp Gln Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  290
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  290

Val Ala Val Ile Trp Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  291
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  291

Val Ala Val Ile Trp Gln Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  292
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  292

Val Ala Val Ile Trp Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  293
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  293

Val Ala Val Ile Trp Gln Gly Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  294
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  294

Val Gly Asn Ile Lys Ala Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  295
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  295

Val Gly Asn Ile Lys Ala Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  296
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  296

Val Gly Asn Ile Lys Ala Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  297
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  297

Val Gly Asn Ile Lys Ala Gly Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  298
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  298

Val Gly Asn Ile Lys Gln Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  299
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  299

Val Gly Asn Ile Lys Gln Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  300
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  300

Val Gly Asn Ile Lys Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  301
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  301

Val Gly Asn Ile Lys Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  302
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  302

Val Gly Asn Ile Lys Gln Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  303
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  303

Val Gly Asn Ile Lys Gln Gly Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  304
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  304

Val Gly Asn Ile Trp Ala Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  305
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  305

Val Gly Asn Ile Trp Ala Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  306
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  306

Val Gly Asn Ile Trp Ala Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  307
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  307

Val Gly Asn Ile Trp Ala Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  308
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  308

Val Gly Asn Ile Trp Gln Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  309
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  309

Val Gly Asn Ile Trp Gln Asp Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  310
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  310

Val Gly Asn Ile Trp Gln Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  311
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  311

Val Gly Asn Ile Trp Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  312
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  312

Val Gly Asn Ile Trp Gln Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  313
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  313

Val Gly Asn Ile Trp Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  314
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  314

Val Gly Asn Ile Trp Gln Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  315
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  315

Val Gly Asn Ile Trp Gln Gly Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  316
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  316

Val Gly Val Ile Lys Ala Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  317
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  317

Val Gly Val Ile Lys Ala Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  318
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  318

Val Gly Val Ile Lys Ala Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  319
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  319

Val Gly Val Ile Lys Gln Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  320
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  320

Val Gly Val Ile Lys Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  321
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  321

Val Gly Val Ile Lys Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  322
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  322

Val Gly Val Ile Trp Ala Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  323
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  323

Val Gly Val Ile Trp Ala Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  324
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  324

Val Gly Val Ile Trp Ala Asp Gly Ser Glu Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  325
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  325

Val Gly Val Ile Trp Ala Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  326
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  326

Val Gly Val Ile Trp Ala Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  327
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  327

Val Gly Val Ile Trp Ala Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  328
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  328

Val Gly Val Ile Trp Ala Asp Gly Ser Thr Asn Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  329
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  329

Val Gly Val Ile Trp Gln Asp Gly Ser Glu Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  330
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  330

Val Gly Val Ile Trp Gln Asp Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  331
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  331

Val Gly Val Ile Trp Gln Asp Gly Ser Glu Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  332
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  332

Val Gly Val Ile Trp Gln Asp Gly Ser Thr Lys Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  333
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  333

Val Gly Val Ile Trp Gln Asp Gly Ser Thr Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  334
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  334

Val Gly Val Ile Trp Gln Asp Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  335
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  335

Val Gly Val Ile Trp Gln Gly Gly Ser Glu Lys Tyr Val Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  336
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR2

<400>  336

Val Gly Val Ile Trp Gln Gly Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  337
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  337

Ala Phe Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  338
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  338

Ala Trp Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  339
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  339

Ala Tyr Gly Ala Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  340
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  340

Ala Tyr Gly Glu Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  341
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  341

Ala Tyr Gly Phe Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  342
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  342

Ala Tyr Gly Gly Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  343
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  343

Ala Tyr Gly His Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  344
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  344

Ala Tyr Gly Ile Tyr Trp Tyr Ile Asp Asn 
1               5                   10  


<210>  345
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  345

Ala Tyr Gly Asn Trp Trp Tyr Ile Asp Val 
1               5                   10  


<210>  346
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  346

Ala Tyr Gly Asn Tyr Phe Tyr Ile Asp Val 
1               5                   10  


<210>  347
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  347

Ala Tyr Gly Asn Tyr Phe Tyr Ile Asp Trp 
1               5                   10  


<210>  348
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  348

Ala Tyr Gly Asn Tyr His Tyr Ile Asp Val 
1               5                   10  


<210>  349
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  349

Ala Tyr Gly Asn Tyr Pro Tyr Ile Asp Val 
1               5                   10  


<210>  350
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  350

Ala Tyr Gly Asn Tyr Gln Tyr Ile Asp Val 
1               5                   10  


<210>  351
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  351

Ala Tyr Gly Asn Tyr Ser Tyr Ile Asp Val 
1               5                   10  


<210>  352
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  352

Ala Tyr Gly Asn Tyr Val Tyr Ile Asp Val 
1               5                   10  


<210>  353
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  353

Ala Tyr Gly Asn Tyr Trp Tyr Ala Asp Val 
1               5                   10  


<210>  354
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  354

Ala Tyr Gly Asn Tyr Trp Tyr Gly Asp Val 
1               5                   10  


<210>  355
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  355

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Ala 
1               5                   10  


<210>  356
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  356

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Glu 
1               5                   10  


<210>  357
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  357

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Phe 
1               5                   10  


<210>  358
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  358

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Gly 
1               5                   10  


<210>  359
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  359

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp His 
1               5                   10  


<210>  360
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  360

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Ile 
1               5                   10  


<210>  361
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  361

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Lys 
1               5                   10  


<210>  362
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  362

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Leu 
1               5                   10  


<210>  363
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  363

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Met 
1               5                   10  


<210>  364
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  364

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Ser 
1               5                   10  


<210>  365
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  365

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Thr 
1               5                   10  


<210>  366
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  366

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Trp 
1               5                   10  


<210>  367
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  367

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Tyr 
1               5                   10  


<210>  368
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  368

Ala Tyr Gly Asn Tyr Trp Tyr Ile Glu Val 
1               5                   10  


<210>  369
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  369

Ala Tyr Gly Asn Tyr Trp Tyr Leu Asp Val 
1               5                   10  


<210>  370
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  370

Ala Tyr Gly Asn Tyr Trp Tyr Met Asp Val 
1               5                   10  


<210>  371
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  371

Ala Tyr Gly Asn Tyr Trp Tyr Ser Asp Val 
1               5                   10  


<210>  372
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  372

Ala Tyr Gly Asn Tyr Trp Tyr Thr Asp Val 
1               5                   10  


<210>  373
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  373

Ala Tyr Gly Asn Tyr Trp Tyr Val Asp Val 
1               5                   10  


<210>  374
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  374

Ala Tyr Gly Asn Tyr Trp Tyr Tyr Asp Val 
1               5                   10  


<210>  375
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  375

Ala Tyr Gly Gln Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  376
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  376

Ala Tyr Gly Arg Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  377
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  377

Ala Tyr Gly Ser Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  378
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  378

Ala Tyr Gly Thr Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  379
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  379

Ala Tyr Gly Val Tyr Trp Tyr Ile Asp Arg 
1               5                   10  


<210>  380
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  380

Ala Tyr Gly Val Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  381
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  381

Ala Tyr Gly Trp Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  382
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  382

Ala Tyr Gly Tyr Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  383
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  383

Asp Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  384
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  384

Glu Tyr Gly Asn Tyr Trp Tyr Ile Asp Arg 
1               5                   10  


<210>  385
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  385

Glu Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  386
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  386

His Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  387
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  387

Ile Tyr Gly Asn Tyr Trp Tyr Ile Asp Arg 
1               5                   10  


<210>  388
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  388

Ile Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  389
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  389

Leu Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  390
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  390

Met Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  391
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  391

Gln Tyr Gly Asn Tyr Trp Tyr Ile Asp Arg 
1               5                   10  


<210>  392
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  392

Gln Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  393
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  393

Ser Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  394
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  394

Val Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  395
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  395

Trp Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  396
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion HCDR3

<400>  396

Ala Tyr Gly Asn Val Trp Tyr Ile Asp Val 
1               5                   10  


<210>  397
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR1

<400>  397

Lys Ser Ser Glu Ser Val Gly Asn Asp Leu Ala 
1               5                   10      


<210>  398
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR1

<400>  398

Lys Ser Ser Glu Ser Val Gly Asn Asp Val Ala 
1               5                   10      


<210>  399
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR1

<400>  399

Lys Ser Ser Glu Ser Val Ser Asn Asp Leu Ala 
1               5                   10      


<210>  400
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR2

<400>  400

Tyr Ala Phe His Arg Glu Ser 
1               5           


<210>  401
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR2

<400>  401

Tyr Ala Phe His Arg Glu Thr 
1               5           


<210>  402
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR2

<400>  402

Tyr Ala Phe His Arg Phe Ala 
1               5           


<210>  403
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR2

<400>  403

Tyr Ala Phe His Arg Phe Ser 
1               5           


<210>  404
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR2

<400>  404

Tyr Ala Phe Pro Arg Phe Thr 
1               5           


<210>  405
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR2

<400>  405

Tyr Ala Phe Thr Arg Phe Ser 
1               5           


<210>  406
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR2

<400>  406

Tyr Ala Phe Thr Arg Phe Thr 
1               5           


<210>  407
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR3

<400>  407

His Gln Ala Tyr Ser Asn Pro Tyr Thr 
1               5                   


<210>  408
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion LCDR3

<400>  408

Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  409
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion consensus LCDR1

<400>  409

Lys Ser Ser Gln Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  410
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion consensus LCDR2

<400>  410

Tyr Ala Phe His Arg Phe Thr 
1               5           


<210>  411
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion consensus LCDR3

<400>  411

His Gln Ala Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  412
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion consensus HCDR1

<400>  412

Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  413
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion consensus HCDR2

<400>  413

Leu Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  414
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-PD1 antibody molecule or antigen-binding portion consensus HCDR3

<400>  414

Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10  


<210>  415
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  415

Met Val Arg Arg Val Gln Pro Asp Arg Lys Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val 
            20                  25                  30          


Asp Phe Asn Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Val Val Glu Asp Lys Asn Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg His Ser Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His Glu Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Thr Gly Arg Glu Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Thr Thr Gly Arg Gln Ala Ser Leu Lys Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Glu Gly Gln 
            260                 265                 270         


Ser Ser Leu Thr Val Thr Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Lys Leu Gly Val Thr Asn Ala Ser Leu Val 
    290                 295                 300                 


Leu Phe Arg Pro Gly Ser Val Arg Gly Ile Asn Gly Ser Ile Ser Leu 
305                 310                 315                 320 


Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Leu Cys Leu Leu Ser 
                325                 330                 335     


Lys Cys 
        


<210>  416
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  416

Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          


Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              


Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  


Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  


Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         


His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             


Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 


Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 


Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     


Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         


Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             


Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 


Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 


Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     


Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         


Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             


Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 


Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 


Arg Arg Thr Phe Leu His Ala Val Asp Val Val Leu Asp Pro Asp Thr 
                325                 330                 335     


Ala His Pro Asp Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg 
            340                 345                 350         


Cys Pro Phe Arg His Leu Gly Glu Ser Val Pro Asp Asn Pro Glu Arg 
        355                 360                 365             


Phe Asp Ser Gln Pro Cys Val Leu Gly Arg Glu Ser Phe Ala Ser Gly 
    370                 375                 380                 


Lys His Tyr Trp Glu Val Glu Val Glu Asn Val Ile Glu Trp Thr Val 
385                 390                 395                 400 


Gly Val Cys Arg Asp Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile 
                405                 410                 415     


Pro Gln Asn Gly Phe Trp Thr Leu Glu Met His Lys Gly Gln Tyr Arg 
            420                 425                 430         


Ala Val Ser Ser Pro Asp Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys 
        435                 440                 445             


Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr 
    450                 455                 460                 


Asn Met Arg Asp Arg Ser His Ile Tyr Thr Cys Pro Arg Ser Ala Phe 
465                 470                 475                 480 


Ser Val Pro Val Arg Pro Phe Phe Arg Leu Gly Cys Glu Asp Ser Pro 
                485                 490                 495     


Ile Phe Ile Cys Pro Ala Leu Thr Gly Ala Asn Gly Val Thr Val Pro 
            500                 505                 510         


Glu Glu Gly Leu Thr Leu His Arg Val Gly Thr His Gln Ser Leu 
        515                 520                 525         

