                               SEQUENCE LISTING

<110> NEW YORK UNIVERSITY
 
<120> INDUCTION AND ENHANCEMENT OF ANTITUMOR IMMUNITY INVOLVING SINDBIS
      VIRUS VECTORS EXPRESSING IMMUNE CHECKPOINT PROTEINS

<130> 27522-0222WO2

<140> PCT/US2019/020562
<141> 2019-03-04

<150> 62/725,802
<151> 2018-08-31

<150> 62/638,773
<151> 2018-03-05

<160> 28    

<170> PatentIn version 3.5

<210> 1
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly 
1               5                   10      


<210> 2
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Ser 
1               5                   10      


<210> 3
<211> 9
<212> PRT
<213> Homo sapiens

<400> 3
Leu Leu Met Trp Ile Thr Gln Cys Phe 
1               5                   


<210> 4
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4
Arg Gly Pro Glu Ser Arg Leu Leu Glu 
1               5                   


<210> 5
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      survivin sequence

<400> 5
Ala Phe Leu Thr Val Lys Lys Gln Met 
1               5                   


<210> 6
<211> 180
<212> PRT
<213> Homo sapiens

<400> 6
Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210> 7
<211> 752
<212> DNA
<213> Homo sapiens

<400> 7
atcctcgtgg gccctgacct tctctctgag agccgggcag aggctccgga gccatgcagg       60

ccgaaggccg gggcacaggg ggttcgacgg gcgatgctga tggcccagga ggccctggca      120

ttcctgatgg cccagggggc aatgctggcg gcccaggaga ggcgggtgcc acgggcggca      180

gaggtccccg gggcgcaggg gcagcaaggg cctcggggcc gggaggaggc gccccgcggg      240

gtccgcatgg cggcgcggct tcagggctga atggatgctg cagatgcggg gccagggggc      300

cggagagccg cctgcttgag ttctacctcg ccatgccttt cgcgacaccc atggaagcag      360

agctggcccg caggagcctg gcccaggatg ccccaccgct tcccgtgcca ggggtgcttc      420

tgaaggagtt cactgtgtcc ggcaacatac tgactatccg actgactgct gcagaccacc      480

gccaactgca gctctccatc agctcctgtc tccagcagct ttccctgttg atgtggatca      540

cgcagtgctt tctgcccgtg tttttggctc agcctccctc agggcagagg cgctaagccc      600

agcctggcgc cccttcctag gtcatgcctc ctcccctagg gaatggtccc agcacgagtg      660

gccagttcat tgtgggggcc tgattgtttg tcgctggagg aggacggctt acatgtttgt      720

ttctgtagaa aataaaactg agctacgaaa aa                                    752


<210> 8
<211> 254
<212> PRT
<213> Homo sapiens

<400> 8
Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210> 9
<211> 870
<212> DNA
<213> Homo sapiens

<400> 9
gcgctgtgtc ttcccgcagt ctctcgtcat ggaatacgcc tctgacgctt cactggaccc       60

cgaagccccg tggcctcccg cgccccgcgc tcgcgcctgc cgcgtactgc cttgggccct      120

ggtcgcgggg ctgctgctgc tgctgctgct cgctgccgcc tgcgccgtct tcctcgcctg      180

cccctgggcc gtgtccgggg ctcgcgcctc gcccggctcc gcggccagcc cgagactccg      240

cgagggtccc gagctttcgc ccgacgatcc cgccggcctc ttggacctgc ggcagggcat      300

gtttgcgcag ctggtggccc aaaatgttct gctgatcgat gggcccctga gctggtacag      360

tgacccaggc ctggcaggcg tgtccctgac ggggggcctg agctacaaag aggacacgaa      420

ggagctggtg gtggccaagg ctggagtcta ctatgtcttc tttcaactag agctgcggcg      480

cgtggtggcc ggcgagggct caggctccgt ttcacttgcg ctgcacctgc agccactgcg      540

ctctgctgct ggggccgccg ccctggcttt gaccgtggac ctgccacccg cctcctccga      600

ggctcggaac tcggccttcg gtttccaggg ccgcttgctg cacctgagtg ccggccagcg      660

cctgggcgtc catcttcaca ctgaggccag ggcacgccat gcctggcagc ttacccaggg      720

cgccacagtc ttgggactct tccgggtgac ccccgaaatc ccagccggac tcccttcacc      780

gaggtcggaa taacgcccag cctgggtgca gcccacctgg acagagtccg aatcctactc      840

catccttcat ggagacccct ggtgctgggt                                       870


<210> 10
<211> 309
<212> PRT
<213> Mus musculus

<400> 10
Met Asp Gln His Thr Leu Asp Val Glu Asp Thr Ala Asp Ala Arg His 
1               5                   10                  15      


Pro Ala Gly Thr Ser Cys Pro Ser Asp Ala Ala Leu Leu Arg Asp Thr 
            20                  25                  30          


Gly Leu Leu Ala Asp Ala Ala Leu Leu Ser Asp Thr Val Arg Pro Thr 
        35                  40                  45              


Asn Ala Ala Leu Pro Thr Asp Ala Ala Tyr Pro Ala Val Asn Val Arg 
    50                  55                  60                  


Asp Arg Glu Ala Ala Trp Pro Pro Ala Leu Asn Phe Cys Ser Arg His 
65                  70                  75                  80  


Pro Lys Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala 
                85                  90                  95      


Ala Cys Val Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr 
            100                 105                 110         


Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln 
        115                 120                 125             


Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly 
    130                 135                 140                 


Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys 
145                 150                 155                 160 


Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr 
                165                 170                 175     


Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val 
            180                 185                 190         


Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro 
        195                 200                 205             


Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val 
    210                 215                 220                 


Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr 
225                 230                 235                 240 


Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser 
                245                 250                 255     


Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly 
            260                 265                 270         


Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu 
        275                 280                 285             


Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro 
    290                 295                 300                 


Asp Asn Pro Trp Glu 
305                 


<210> 11
<211> 1231
<212> DNA
<213> Mus musculus

<400> 11
gataaagcac gggcactggc gggagacgtg cactgaccga ccgtggtaat ggaccagcac       60

acacttgatg tggaggatac cgcggatgcc agacatccag caggtacttc gtgcccctcg      120

gatgcggcgc tcctcagaga taccgggctc ctcgcggacg ctgcgctcct ctcagatact      180

gtgcgcccca caaatgccgc gctccccacg gatgctgcct accctgcggt taatgttcgg      240

gatcgcgagg ccgcgtggcc gcctgcactg aacttctgtt cccgccaccc aaagctctat      300

ggcctagtcg ctttggtttt gctgcttctg atcgccgcct gtgttcctat cttcacccgc      360

accgagcctc ggccagcgct cacaatcacc acctcgccca acctgggtac ccgagagaat      420

aatgcagacc aggtcacccc tgtttcccac attggctgcc ccaacactac acaacagggc      480

tctcctgtgt tcgccaagct actggctaaa aaccaagcat cgttgtgcaa tacaactctg      540

aactggcaca gccaagatgg agctgggagc tcatacctat ctcaaggtct gaggtacgaa      600

gaagacaaaa aggagttggt ggtagacagt cccgggctct actacgtatt tttggaactg      660

aagctcagtc caacattcac aaacacaggc cacaaggtgc agggctgggt ctctcttgtt      720

ttgcaagcaa agcctcaggt agatgacttt gacaacttgg ccctgacagt ggaactgttc      780

ccttgctcca tggagaacaa gttagtggac cgttcctgga gtcaactgtt gctcctgaag      840

gctggccacc gcctcagtgt gggtctgagg gcttatctgc atggagccca ggatgcatac      900

agagactggg agctgtctta tcccaacacc accagctttg gactctttct tgtgaaaccc      960

gacaacccat gggaatgaga actatccttc ttgtgactcc tagttgctaa gtcctcaagc     1020

tgctatgttt tatggggtct gagcaggggt cccttccatg actttctctt gtctttaact     1080

ggacttggta tttattctga gcatagctca gacaagactt tatataattc actagatagc     1140

attagtaaac tgctgggcag ctgctagata aaaaaaaatt tctaaatcaa agtttatatt     1200

tatattaata tataaaaata aatgtgtttg t                                    1231


<210> 12
<211> 183
<212> PRT
<213> Homo sapiens

<400> 12
Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210> 13
<211> 552
<212> DNA
<213> Homo sapiens

<400> 13
atggaaaggg tccaacccct ggaagagaat gtgggaaatg cagccaggcc aagattcgag       60

aggaacaagc tattgctggt ggcctctgta attcagggac tggggctgct cctgtgcttc      120

acctacatct gcctgcactt ctctgctctt caggtatcac atcggtatcc tcgaattcaa      180

agtatcaaag tacaatttac cgaatataag aaggagaaag gtttcatcct cacttcccaa      240

aaggaggatg aaatcatgaa ggtgcagaac aactcagtca tcatcaactg tgatgggttt      300

tatctcatct ccctgaaggg ctacttctcc caggaagtca acattagcct tcattaccag      360

aaggatgagg agcccctctt ccaactgaag aaggtcaggt ctgtcaactc cttgatggtg      420

gcctctctga cttacaaaga caaagtctac ttgaatgtga ccactgacaa tacctccctg      480

gatgacttcc atgtgaatgg cggagaactg attcttatcc atcaaaatcc tggtgaattc      540

tgtgtccttt ga                                                          552


<210> 14
<211> 288
<212> PRT
<213> Homo sapiens

<400> 14
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210> 15
<211> 2115
<212> DNA
<213> Homo sapiens

<400> 15
agtttccctt ccgctcacct ccgcctgagc agtggagaag gcggcactct ggtggggctg       60

ctccaggcat gcagatccca caggcgccct ggccagtcgt ctgggcggtg ctacaactgg      120

gctggcggcc aggatggttc ttagactccc cagacaggcc ctggaacccc cccaccttct      180

ccccagccct gctcgtggtg accgaagggg acaacgccac cttcacctgc agcttctcca      240

acacatcgga gagcttcgtg ctaaactggt accgcatgag ccccagcaac cagacggaca      300

agctggccgc cttccccgag gaccgcagcc agcccggcca ggactgccgc ttccgtgtca      360

cacaactgcc caacgggcgt gacttccaca tgagcgtggt cagggcccgg cgcaatgaca      420

gcggcaccta cctctgtggg gccatctccc tggcccccaa ggcgcagatc aaagagagcc      480

tgcgggcaga gctcagggtg acagagagaa gggcagaagt gcccacagcc caccccagcc      540

cctcacccag gccagccggc cagttccaaa ccctggtggt tggtgtcgtg ggcggcctgc      600

tgggcagcct ggtgctgcta gtctgggtcc tggccgtcat ctgctcccgg gccgcacgag      660

ggacaatagg agccaggcgc accggccagc ccctgaagga ggacccctca gccgtgcctg      720

tgttctctgt ggactatggg gagctggatt tccagtggcg agagaagacc ccggagcccc      780

ccgtgccctg tgtccctgag cagacggagt atgccaccat tgtctttcct agcggaatgg      840

gcacctcatc ccccgcccgc aggggctcag ctgacggccc tcggagtgcc cagccactga      900

ggcctgagga tggacactgc tcttggcccc tctgaccggc ttccttggcc accagtgttc      960

tgcagaccct ccaccatgag cccgggtcag cgcatttcct caggagaagc aggcagggtg     1020

caggccattg caggccgtcc aggggctgag ctgcctgggg gcgaccgggg ctccagcctg     1080

cacctgcacc aggcacagcc ccaccacagg actcatgtct caatgcccac agtgagccca     1140

ggcagcaggt gtcaccgtcc cctacaggga gggccagatg cagtcactgc ttcaggtcct     1200

gccagcacag agctgcctgc gtccagctcc ctgaatctct gctgctgctg ctgctgctgc     1260

tgctgctgcc tgcggcccgg ggctgaaggc gccgtggccc tgcctgacgc cccggagcct     1320

cctgcctgaa cttgggggct ggttggagat ggccttggag cagccaaggt gcccctggca     1380

gtggcatccc gaaacgccct ggacgcaggg cccaagactg ggcacaggag tgggaggtac     1440

atggggctgg ggactcccca ggagttatct gctccctgca ggcctagaga agtttcaggg     1500

aaggtcagaa gagctcctgg ctgtggtggg cagggcagga aacccctcca cctttacaca     1560

tgcccaggca gcacctcagg ccctttgtgg ggcagggaag ctgaggcagt aagcgggcag     1620

gcagagctgg aggcctttca ggcccagcca gcactctggc ctcctgccgc cgcattccac     1680

cccagcccct cacaccactc gggagaggga catcctacgg tcccaaggtc aggagggcag     1740

ggctggggtt gactcaggcc cctcccagct gtggccacct gggtgttggg agggcagaag     1800

tgcaggcacc tagggccccc catgtgccca ccctgggagc tctccttgga acccattcct     1860

gaaattattt aaaggggttg gccgggctcc caccagggcc tgggtgggaa ggtacaggcg     1920

ttcccccggg gcctagtacc cccgccgtgg cctatccact cctcacatcc acacactgca     1980

cccccactcc tggggcaggg ccaccagcat ccaggcggcc agcaggcacc tgagtggctg     2040

ggacaaggga tcccccttcc ctgtggttct attatattat aattataatt aaatatgaga     2100

gcatgctaag gaaaa                                                      2115


<210> 16
<211> 900
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
gccaccatgc agatcccaca ggcgccctgg ccagtcgtct gggcggtgct acaactgggc       60

tggcggccag gatggttctt agactcccca gacaggccct ggaacccccc caccttctcc      120

ccagccctgc tcgtggtgac cgaaggggac aacgccacct tcacctgcag cttctccaac      180

acatcggaga gcttcgtgct aaactggtac cgcatgagcc ccagcaacca gacggacaag      240

ctggccgcct tccccgagga ccgcagccag cccggccagg actgccgctt ccgtgtcaca      300

caactgccca acgggcgtga cttccacatg agcgtggtca gggcccggcg caatgacagc      360

ggcacctacc tctgtggggc catctccctg gcccccaagg cgcagatcaa agagagcctg      420

cgggcagagc tcagggtgac agagagaagg gcagaagtgc ccacagccca ccccagcccc      480

tcacccaggc cagccggcca gttccaaacc ctggtggagc ctaagagctg cgacaaaaca      540

cacacttgcc caccctgcgg aggaggctct agcggaggag ggtctggagg ccagccaaga      600

gagccccagg tgtacacact gcctccctct cgagacgagc ttacaaagaa ccaggtgtct      660

ctgacctgtc tggttaaagg cttctatcct agcgacattg ctgtggagtg ggaaagcaac      720

ggccagccag agaataacta caagactaca ccacctgtgc tggactctga tggcagcttc      780

tttctttaca gcaaactgac agttgacaag tctaggtggc agcaaggcaa cgtgttctct      840

tgcagcgtga tgcacaacca ctacacacag aagtctctta gcctgagccc tggcaaatga      900


<210> 17
<211> 297
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Glu Pro Lys Ser Cys Asp 
                165                 170                 175     


Lys Thr His Thr Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        195                 200                 205             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    210                 215                 220                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
225                 230                 235                 240 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                245                 250                 255     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            260                 265                 270         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Asn His Tyr Thr Gln 
        275                 280                 285             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295         


<210> 18
<211> 288
<212> PRT
<213> Homo sapiens

<400> 18
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210> 19
<211> 288
<212> PRT
<213> Mus musculus

<400> 19
Met Trp Val Arg Gln Val Pro Trp Ser Phe Thr Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Ser Trp Gln Ser Gly Trp Leu Leu Glu Val Pro Asn Gly Pro Trp 
            20                  25                  30          


Arg Ser Leu Thr Phe Tyr Pro Ala Trp Leu Thr Val Ser Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Leu Ser Asn Trp Ser Glu Asp Leu Met 
    50                  55                  60                  


Leu Asn Trp Asn Arg Leu Ser Pro Ser Asn Gln Thr Glu Lys Gln Ala 
65                  70                  75                  80  


Ala Phe Cys Asn Gly Leu Ser Gln Pro Val Gln Asp Ala Arg Phe Gln 
                85                  90                  95      


Ile Ile Gln Leu Pro Asn Arg His Asp Phe His Met Asn Ile Leu Asp 
            100                 105                 110         


Thr Arg Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


His Pro Lys Ala Lys Ile Glu Glu Ser Pro Gly Ala Glu Leu Val Val 
    130                 135                 140                 


Thr Glu Arg Ile Leu Glu Thr Ser Thr Arg Tyr Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Lys Pro Glu Gly Arg Phe Gln Gly Met Val Ile Gly Ile Met Ser Ala 
                165                 170                 175     


Leu Val Gly Ile Pro Val Leu Leu Leu Leu Ala Trp Ala Leu Ala Val 
            180                 185                 190         


Phe Cys Ser Thr Ser Met Ser Glu Ala Arg Gly Ala Gly Ser Lys Asp 
        195                 200                 205             


Asp Thr Leu Lys Glu Glu Pro Ser Ala Ala Pro Val Pro Ser Val Ala 
    210                 215                 220                 


Tyr Glu Glu Leu Asp Phe Gln Gly Arg Glu Lys Thr Pro Glu Leu Pro 
225                 230                 235                 240 


Thr Ala Cys Val His Thr Glu Tyr Ala Thr Ile Val Phe Thr Glu Gly 
                245                 250                 255     


Leu Gly Ala Ser Ala Met Gly Arg Arg Gly Ser Ala Asp Gly Leu Gln 
            260                 265                 270         


Gly Pro Arg Pro Pro Arg His Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210> 20
<211> 288
<212> PRT
<213> Macaca nemestrina

<400> 20
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Glu Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Leu Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Ala Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Ala Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Gln Gly Thr Ile Glu Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Ala Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Leu Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Pro Arg Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210> 21
<211> 207
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Arg Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro Asn 
1               5                   10                  15      


Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro Val Ser His 
            20                  25                  30          


Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val Phe Ala Lys 
        35                  40                  45              


Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn Trp 
    50                  55                  60                  


His Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln Gly Leu Arg 
65                  70                  75                  80  


Tyr Glu Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro Gly Leu Tyr 
                85                  90                  95      


Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr Asn Thr Gly 
            100                 105                 110         


His Lys Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala Lys Pro Gln 
        115                 120                 125             


Val Asp Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu Phe Pro Cys 
    130                 135                 140                 


Ser Met Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln Leu Leu Leu 
145                 150                 155                 160 


Leu Lys Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala Tyr Leu His 
                165                 170                 175     


Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr Pro Asn Thr 
            180                 185                 190         


Thr Ser Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro Trp Glu 
        195                 200                 205         


<210> 22
<211> 630
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 22
gccaccatgc gcaccgagcc tcggccagcg ctcacaatca ccacctcgcc caacctgggt       60

acccgagaga ataatgcaga ccaggtcacc cctgtttccc acattggctg ccccaacact      120

acacaacagg gctctcctgt gttcgccaag ctactggcta aaaaccaagc atcgttgtgc      180

aatacaactc tgaactggca cagccaagat ggagctggga gctcatacct atctcaaggt      240

ctgaggtacg aagaagacaa aaaggagttg gtggtagaca gtcccgggct ctactacgta      300

tttttggaac tgaagctcag tccaacattc acaaacacag gccacaaggt gcagggctgg      360

gtctctcttg ttttgcaagc aaagcctcag gtagatgact ttgacaactt ggccctgaca      420

gtggaactgt tcccttgctc catggagaac aagttagtgg accgttcctg gagtcaactg      480

ttgctcctga aggctggcca ccgcctcagt gtgggtctga gggcttatct gcatggagcc      540

caggatgcat acagagactg ggagctgtct tatcccaaca ccaccagctt tggactcttt      600

cttgtgaaac ccgacaaccc atgggaatga                                       630


<210> 23
<211> 21
<212> PRT
<213> Mus musculus

<400> 23
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp 
            20      


<210> 24
<211> 28
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      GCN4 sequence

<400> 24
Ile Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr 
1               5                   10                  15      


His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu 
            20                  25              


<210> 25
<211> 197
<212> PRT
<213> Mus musculus

<400> 25
Met Glu Gly Glu Gly Val Gln Pro Leu Asp Glu Asn Leu Glu Asn Gly 
1               5                   10                  15      


Ser Arg Pro Arg Phe Lys Trp Lys Lys Thr Leu Arg Leu Val Val Ser 
            20                  25                  30          


Gly Ile Lys Gly Ala Gly Met Leu Leu Cys Phe Ile Tyr Val Cys Leu 
        35                  40                  45              


Gln Leu Ser Ser Ser Pro Ala Lys Asp Pro Pro Ile Gln Arg Leu Arg 
    50                  55                  60                  


Gly Ala Val Thr Arg Cys Glu Asp Gly Gln Leu Phe Ser Ser Tyr Lys 
65                  70                  75                  80  


Asn Glu Tyr Gln Thr Met Glu Val Gln Asn Asn Ser Val Val Ile Lys 
                85                  90                  95      


Cys Asp Gly Leu Tyr Ile Ile Tyr Leu Lys Gly Ser Phe Phe Gln Glu 
            100                 105                 110         


Val Lys Ile Asp Leu His Phe Arg Glu Asp His Asn Pro Ile Ser Ile 
        115                 120                 125             


Pro Met Leu Asn Asp Gly Arg Arg Ile Val Phe Thr Val Val Ala Ser 
    130                 135                 140                 


Leu Ala Phe Lys Asp Lys Val Tyr Leu Thr Val Asn Ala Pro Asp Thr 
145                 150                 155                 160 


Leu Cys Glu His Leu Gln Ile Asn Asp Gly Glu Leu Ile Val Val Gln 
                165                 170                 175     


Leu Thr Pro Gly Tyr Cys Ala Pro Glu Gly Ser Tyr His Ser Thr Val 
            180                 185                 190         


Asn Gln Val Pro Leu 
        195         


<210> 26
<211> 597
<212> DNA
<213> Mus musculus

<400> 26
atggaagggg aaggggttca acccctggat gagaatctgg aaaacggatc aaggccaaga       60

ttcaagtgga agaagacgct aaggctggtg gtctctggga tcaagggagc agggatgctt      120

ctgtgcttca tctatgtctg cctgcaactc tcttcctctc cggcaaagga ccctccaatc      180

caaagactca gaggagcagt taccagatgt gaggatgggc aactattcat cagctcatac      240

aagaatgagt atcaaactat ggaggtgcag aacaattcgg ttgtcatcaa gtgcgatggg      300

ctttatatca tctacctgaa gggctccttt ttccaggagg tcaagattga ccttcatttc      360

cgggaggatc ataatcccat ctctattcca atgctgaacg atggtcgaag gattgtcttc      420

actgtggtgg cctctttggc tttcaaagat aaagtttacc tgactgtaaa tgctcctgat      480

actctctgcg aacacctcca gataaatgat ggggagctga ttgttgtcca gctaacgcct      540

ggatactgtg ctcctgaagg atcttaccac agcactgtga accaagtacc actgtga         597


<210> 27
<211> 405
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            20                  25                  30          


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        35                  40                  45              


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
65                  70                  75                  80  


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                85                  90                  95      


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            100                 105                 110         


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        115                 120                 125             


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    130                 135                 140                 


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
145                 150                 155                 160 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                165                 170                 175     


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            180                 185                 190         


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        195                 200                 205             


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    210                 215                 220                 


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
225                 230                 235                 240 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys Gly Gly Gly Ser Ser Gly 
                245                 250                 255     


Gly Gly Ser Gly Ser Pro Ala Lys Asp Pro Pro Ile Gln Arg Leu Arg 
            260                 265                 270         


Gly Ala Val Thr Arg Cys Glu Asp Gly Gln Leu Phe Ile Ser Ser Tyr 
        275                 280                 285             


Lys Asn Glu Tyr Gln Thr Met Glu Val Gln Asn Asn Ser Val Val Ile 
    290                 295                 300                 


Lys Cys Asp Gly Leu Tyr Ile Ile Tyr Leu Lys Gly Ser Phe Phe Gln 
305                 310                 315                 320 


Glu Val Lys Ile Asp Leu His Phe Arg Glu Asp His Asn Pro Ile Ser 
                325                 330                 335     


Ile Pro Met Leu Asn Asp Gly Arg Arg Ile Val Phe Thr Val Val Ala 
            340                 345                 350         


Ser Leu Ala Phe Lys Asp Lys Val Tyr Leu Thr Val Asn Ala Pro Asp 
        355                 360                 365             


Thr Leu Cys Glu His Leu Gln Asn Asp Gly Glu Leu Ile Val Val Gln 
    370                 375                 380                 


Leu Thr Pro Gly Tyr Cys Ala Pro Glu Gly Ser Tyr His Ser Thr Val 
385                 390                 395                 400 


Asn Gln Val Pro Leu 
                405 


<210> 28
<211> 1224
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
gccaccatgg gctggtcctg gatcttcctg ttcctgctgt ccggcaccgc cggcgtgcac       60

cctcggggac ccaccatcaa gccctgccct ccctgcaagt gtcccgctcc caacctgctg      120

ggcggcccct ccgtgttcat ctttccaccc aagatcaagg acgtgctgat gatctccctg      180

tctcccatcg tgacctgcgt ggtggtggac gtgtccgagg acgaccccga cgtgcagatc      240

tcctggttcg tgaacaacgt ggaggtgcac accgcccaga cccagaccca ccgggaggac      300

tacaactcca ccctgcgggt ggtgtccgcc ctgcccatcc agcaccagga ctggatgtcc      360

ggcaaggagt tcaagtgcaa ggtgaacaac aaggacctgc ccgcccccat cgagcggacc      420

atctccaagc ccaagggctc cgtgcgggct ccccaggtgt acgtgctgcc tcctcctgag      480

gaggagatga ccaagaagca ggtgaccctg acctgcatgg tgaccgactt catgcccgag      540

gacatctacg tggagtggac caacaacggc aagaccgagc tgaactacaa gaacaccgag      600

cccgtgctgg actccgacgg ctcctacttc atgtactcca agctgcgggt ggagaagaag      660

aactgggtgg agcggaactc ctactcctgc tccgtggtgc acgagggcct gcacaaccac      720

cacaccacca agtccttctc ccggacccct ggcaagggag gaggctctag cggaggaggg      780

tctggatccc ctgccaagga ccctcccatc cagcggctgc ggggcgccgt gacccggtgc      840

gaggacggcc agctgttcat ctcctcctac aagaacgagt accagaccat ggaggtgcag      900

aacaactccg tggtgatcaa gtgcgacggc ctgtacatca tctacctgaa gggctccttc      960

ttccaggagg tgaagatcga cctgcacttc cgggaggacc acaaccccat ctccatcccc     1020

atgctgaacg acggccggcg gatcgtgttc accgtggtgg cctccctggc cttcaaggac     1080

aaggtgtacc tgaccgtgaa cgctcccgac accctgtgcg agcacctgca gaacgacggc     1140

gagctgatcg tggtgcagct gacacccggc tactgcgctc ccgagggctc ctaccactcc     1200

accgtgaacc aggtgcccct gtga                                            1224


