                         SEQUENCE LISTING

<110>  Genomatica, Inc.
       Noble, Michael A
       Hoff, Kevin G
       Lechner, Anna
       Nagarajan, Harish
 
<120>  PRENYLTRANSFERASE VARIANTS AND METHODS FOR PRODUCTION OF 
       PRENYLATED AROMATIC COMPOUNDS

<130>  GNO0093/WO

<140>  PCT/US2019/021448
<141>  2019-03-08

<150>  US 62/640,384
<151>  2018-03-08

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  307
<212>  PRT
<213>  Streptomyces antibioticus

<400>  1

Met Ser Glu Ala Ala Asp Val Glu Arg Val Tyr Ala Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Gly Leu Leu Gly Val Ala Cys Ala Arg Asp Lys Ile Tyr Pro 
            20                  25                  30          


Leu Leu Ser Thr Phe Gln Asp Thr Leu Val Glu Gly Gly Ser Val Val 
        35                  40                  45              


Val Phe Ser Met Ala Ser Gly Arg His Ser Thr Glu Leu Asp Phe Ser 
    50                  55                  60                  


Ile Ser Val Pro Thr Ser His Gly Asp Pro Tyr Ala Thr Val Val Glu 
65                  70                  75                  80  


Lys Gly Leu Phe Pro Ala Thr Gly His Pro Val Asp Asp Leu Leu Ala 
                85                  90                  95      


Asp Thr Gln Lys His Leu Pro Val Ser Met Phe Ala Ile Asp Gly Glu 
            100                 105                 110         


Val Thr Gly Gly Phe Lys Lys Thr Tyr Ala Phe Phe Pro Thr Asp Asn 
        115                 120                 125             


Met Pro Gly Val Ala Glu Leu Ser Ala Ile Pro Ser Met Pro Pro Ala 
    130                 135                 140                 


Val Ala Glu Asn Ala Glu Leu Phe Ala Arg Tyr Gly Leu Asp Lys Val 
145                 150                 155                 160 


Gln Met Thr Ser Met Asp Tyr Lys Lys Arg Gln Val Asn Leu Tyr Phe 
                165                 170                 175     


Ser Glu Leu Ser Ala Gln Thr Leu Glu Ala Glu Ser Val Leu Ala Leu 
            180                 185                 190         


Val Arg Glu Leu Gly Leu His Val Pro Asn Glu Leu Gly Leu Lys Phe 
        195                 200                 205             


Cys Lys Arg Ser Phe Ser Val Tyr Pro Thr Leu Asn Trp Glu Thr Gly 
    210                 215                 220                 


Lys Ile Asp Arg Leu Cys Phe Ala Val Ile Ser Asn Asp Pro Thr Leu 
225                 230                 235                 240 


Val Pro Ser Ser Asp Glu Gly Asp Ile Glu Lys Phe His Asn Tyr Ala 
                245                 250                 255     


Thr Lys Ala Pro Tyr Ala Tyr Val Gly Glu Lys Arg Thr Leu Val Tyr 
            260                 265                 270         


Gly Leu Thr Leu Ser Pro Lys Glu Glu Tyr Tyr Lys Leu Gly Ala Tyr 
        275                 280                 285             


Tyr His Ile Thr Asp Val Gln Arg Gly Leu Leu Lys Ala Phe Asp Ser 
    290                 295                 300                 


Leu Glu Asp 
305         


<210>  2
<211>  305
<212>  PRT
<213>  Streptomyces Sp. Strain Cl190

<400>  2

Met Ser Gly Ala Ala Asp Val Glu Arg Val Tyr Ala Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Gly Leu Leu Asp Val Ser Cys Ala Arg Glu Lys Ile Tyr Pro 
            20                  25                  30          


Leu Leu Thr Val Phe Gln Asp Thr Leu Thr Asp Gly Val Val Val Phe 
        35                  40                  45              


Ser Met Ala Ser Gly Arg Arg Ser Thr Glu Leu Asp Phe Ser Ile Ser 
    50                  55                  60                  


Val Pro Val Ser Gln Gly Asp Pro Tyr Ala Thr Val Val Arg Glu Gly 
65                  70                  75                  80  


Leu Phe Arg Ala Thr Gly Ser Pro Val Asp Glu Leu Leu Ala Asp Thr 
                85                  90                  95      


Val Lys His Leu Pro Val Ser Met Phe Ala Ile Asp Gly Glu Val Thr 
            100                 105                 110         


Gly Gly Phe Lys Lys Thr Tyr Ala Phe Phe Pro Thr Asp Asp Met Pro 
        115                 120                 125             


Gly Val Ala Gln Leu Thr Gly Ile Pro Ser Met Pro Ala Ser Val Ala 
    130                 135                 140                 


Glu Asn Ala Glu Leu Phe Ala Arg Tyr Gly Leu Asp Lys Val Gln Met 
145                 150                 155                 160 


Thr Ser Met Asp Tyr Lys Lys Arg Gln Val Asn Leu Tyr Phe Ser Asp 
                165                 170                 175     


Leu Lys Gln Glu Tyr Leu Gln Pro Glu Ala Val Val Ala Leu Ala Arg 
            180                 185                 190         


Glu Leu Gly Leu Gln Val Pro Gly Glu Leu Gly Leu Glu Phe Cys Lys 
        195                 200                 205             


Arg Ser Phe Ala Val Tyr Pro Thr Leu Asn Trp Asp Thr Gly Lys Ile 
    210                 215                 220                 


Asp Arg Leu Cys Phe Ala Ala Ile Ser Thr Asp Pro Thr Leu Val Pro 
225                 230                 235                 240 


Ser Thr Asp Glu Arg Asp Ile Glu Met Phe Arg Glu Tyr Ala Thr Lys 
                245                 250                 255     


Ala Pro Tyr Ala Tyr Val Gly Glu Lys Arg Thr Leu Val Tyr Gly Leu 
            260                 265                 270         


Thr Leu Ser Pro Thr Glu Glu Tyr Tyr Lys Leu Gly Ala Tyr Tyr His 
        275                 280                 285             


Ile Thr Asp Ile Gln Arg Gln Leu Leu Lys Ala Phe Asp Ala Leu Glu 
    290                 295                 300                 


Asp 
305 


<210>  3
<211>  305
<212>  PRT
<213>  Actinobacteria bacterium OV320

<400>  3

Met Ser Gly Ala Ala Asp Val Glu Arg Val Tyr Ala Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Gly Leu Leu Asp Val Ser Cys Ala Arg Glu Lys Ile Tyr Pro 
            20                  25                  30          


Leu Leu Thr Val Phe Gln Asp Thr Leu Thr Asp Gly Val Val Val Phe 
        35                  40                  45              


Ser Met Ala Ser Gly Arg Arg Ser Thr Glu Leu Asp Phe Ser Ile Ser 
    50                  55                  60                  


Val Pro Val Ser Gln Gly Asp Pro Tyr Ala Thr Val Val Arg Glu Gly 
65                  70                  75                  80  


Leu Phe Arg Ala Thr Gly Ser Pro Val Asp Glu Leu Leu Ala Asp Thr 
                85                  90                  95      


Val Lys His Leu Pro Val Ser Met Phe Ala Ile Asp Gly Glu Val Thr 
            100                 105                 110         


Gly Gly Phe Lys Lys Thr Tyr Ala Phe Phe Pro Thr Asp Asp Met Pro 
        115                 120                 125             


Gly Val Ala Gln Leu Thr Gly Ile Pro Ser Met Pro Ala Ser Val Ala 
    130                 135                 140                 


Glu Asn Ala Glu Leu Phe Ala Arg Tyr Gly Leu Asp Lys Val Gln Met 
145                 150                 155                 160 


Thr Ser Met Asp Tyr Lys Lys Arg Gln Val Asn Leu Tyr Phe Ser Asp 
                165                 170                 175     


Leu Lys Gln Glu Tyr Leu Gln Pro Glu Ala Val Val Ala Leu Ala Arg 
            180                 185                 190         


Glu Leu Gly Leu Gln Val Pro Gly Glu Leu Gly Leu Glu Phe Cys Lys 
        195                 200                 205             


Arg Ser Phe Ala Val Tyr Pro Thr Leu Asn Trp Asp Thr Gly Lys Ile 
    210                 215                 220                 


Asp Arg Leu Cys Phe Ala Ala Ile Ser Thr Asp Pro Thr Leu Val Pro 
225                 230                 235                 240 


Ser Thr Asp Glu Arg Asp Ile Glu Met Phe Arg Glu Tyr Ala Thr Lys 
                245                 250                 255     


Ala Pro Tyr Ala Tyr Val Gly Glu Lys Arg Thr Leu Val Tyr Gly Leu 
            260                 265                 270         


Thr Leu Ser Pro Thr Glu Glu Tyr Tyr Lys Leu Gly Ala Tyr Tyr His 
        275                 280                 285             


Ile Thr Asp Ile Gln Arg Gln Leu Leu Lys Ala Phe Asp Ala Leu Glu 
    290                 295                 300                 


Asp 
305 


<210>  4
<211>  305
<212>  PRT
<213>  Streptomyces tendae

<400>  4

Met Ser Gly Ala Ala Asp Val Glu Arg Val Tyr Ala Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Gly Leu Leu Asp Val Ser Cys Ala Arg Glu Lys Ile Tyr Pro 
            20                  25                  30          


Leu Leu Thr Val Phe Gln Asp Thr Leu Thr Asp Gly Val Val Val Phe 
        35                  40                  45              


Ser Met Ala Ser Gly Arg Arg Ser Thr Glu Leu Asp Phe Ser Ile Ser 
    50                  55                  60                  


Val Pro Val Ser Gln Gly Asp Pro Tyr Ala Thr Val Val Lys Glu Gly 
65                  70                  75                  80  


Leu Phe Arg Ala Thr Gly Ser Pro Val Asp Glu Leu Leu Ala Asp Thr 
                85                  90                  95      


Val Lys His Leu Pro Val Ser Met Phe Ala Ile Asp Gly Glu Val Thr 
            100                 105                 110         


Gly Gly Phe Lys Lys Thr Tyr Ala Phe Phe Pro Thr Asp Asp Met Pro 
        115                 120                 125             


Gly Val Ala Gln Leu Thr Glu Ile Pro Ser Met Pro Ala Ser Val Ala 
    130                 135                 140                 


Glu Asn Ala Glu Leu Phe Ala Arg Tyr Gly Leu Asp Lys Val Gln Met 
145                 150                 155                 160 


Thr Ser Met Asp Tyr Lys Lys Arg Gln Val Asn Leu Tyr Phe Ser Asp 
                165                 170                 175     


Leu Lys Gln Glu Tyr Leu Gln Pro Glu Ala Val Val Ala Leu Ala Arg 
            180                 185                 190         


Glu Leu Gly Leu Gln Val Pro Gly Glu Leu Gly Leu Glu Phe Cys Lys 
        195                 200                 205             


Arg Ser Phe Ala Val Tyr Pro Thr Leu Asn Trp Asp Thr Gly Lys Ile 
    210                 215                 220                 


Asp Arg Leu Cys Phe Ala Ala Ile Ser Thr Asp Pro Thr Leu Val Pro 
225                 230                 235                 240 


Ser Thr Asp Glu Arg Asp Ile Glu Met Phe Arg Glu Tyr Ala Thr Lys 
                245                 250                 255     


Ala Pro Tyr Ala Tyr Val Gly Glu Lys Arg Thr Leu Val Tyr Gly Leu 
            260                 265                 270         


Thr Leu Ser Ser Thr Glu Glu Tyr Tyr Lys Leu Gly Ala Tyr Tyr His 
        275                 280                 285             


Ile Thr Asp Ile Gln Arg Gln Leu Leu Lys Ala Phe Asp Ala Leu Glu 
    290                 295                 300                 


Asp 
305 


<210>  5
<211>  305
<212>  PRT
<213>  Streptomyces sp. Root1310

<400>  5

Met Ser Gly Ala Ala Asp Val Glu Arg Val Tyr Ala Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Gly Leu Leu Asp Val Ser Cys Ala Arg Glu Lys Ile Tyr Pro 
            20                  25                  30          


Leu Leu Thr Val Phe Gln Asp Thr Leu Thr Asp Gly Val Val Val Phe 
        35                  40                  45              


Ser Met Ala Ser Gly Arg Arg Ser Thr Glu Leu Asp Phe Ser Ile Ser 
    50                  55                  60                  


Val Pro Val Ser Gln Gly Asp Pro Tyr Ala Thr Val Val Lys Glu Gly 
65                  70                  75                  80  


Leu Phe Gln Ala Thr Gly Ser Pro Val Asp Glu Leu Leu Ala Asp Thr 
                85                  90                  95      


Val Ala His Leu Pro Val Ser Met Phe Ala Ile Asp Gly Glu Val Thr 
            100                 105                 110         


Gly Gly Phe Lys Lys Thr Tyr Ala Phe Phe Pro Thr Asp Asp Met Pro 
        115                 120                 125             


Gly Val Ala Gln Leu Ala Ala Ile Pro Ser Met Pro Ala Ser Val Ala 
    130                 135                 140                 


Glu Asn Ala Glu Leu Phe Ala Arg Tyr Gly Leu Asp Lys Val Gln Met 
145                 150                 155                 160 


Thr Ser Met Asp Tyr Lys Lys Arg Gln Val Asn Leu Tyr Phe Ser Asp 
                165                 170                 175     


Leu Lys Gln Glu Tyr Leu Gln Pro Glu Ser Val Val Ala Leu Ala Arg 
            180                 185                 190         


Glu Leu Gly Leu Arg Val Pro Gly Glu Leu Gly Leu Glu Phe Cys Lys 
        195                 200                 205             


Arg Ser Phe Ala Val Tyr Pro Thr Leu Asn Trp Asp Thr Gly Lys Ile 
    210                 215                 220                 


Asp Arg Leu Cys Phe Ala Ala Ile Ser Thr Asp Pro Thr Leu Val Pro 
225                 230                 235                 240 


Ser Glu Asp Glu Arg Asp Ile Glu Met Phe Arg Asn Tyr Ala Thr Lys 
                245                 250                 255     


Ala Pro Tyr Ala Tyr Val Gly Glu Lys Arg Thr Leu Val Tyr Gly Leu 
            260                 265                 270         


Thr Leu Ser Ser Thr Glu Glu Tyr Tyr Lys Leu Gly Ala Tyr Tyr His 
        275                 280                 285             


Ile Thr Asp Ile Gln Arg Gln Leu Leu Lys Ala Phe Asp Ala Leu Glu 
    290                 295                 300                 


Asp 
305 


<210>  6
<211>  305
<212>  PRT
<213>  Streptomyces paucisporeus

<400>  6

Met Ser Gly Ala Ala Glu Val Glu Arg Val Tyr Ser Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Gly Leu Leu Asp Val Ala Cys Ser Pro Glu Lys Val Arg Pro 
            20                  25                  30          


Ile Leu Thr Ala Phe Gln Asp Val Leu Ser Asp Gly Val Ile Val Tyr 
        35                  40                  45              


Ser Met Ala Ser Gly Arg His Ala Thr Glu Leu Asp Phe Ser Ile Ser 
    50                  55                  60                  


Val Pro Ala Asp His Gly Asp Pro Tyr Thr Ala Ala Leu Ala His Gly 
65                  70                  75                  80  


Leu Ile Pro Glu Thr Asp His Pro Val Gly Asn Leu Leu Ala Asp Thr 
                85                  90                  95      


Gln Lys Ala Leu Pro Val Ser Met Phe Ala Val Asp Gly Glu Val Thr 
            100                 105                 110         


Gly Gly Phe Lys Lys Thr Tyr Ala Phe Phe Pro Thr Asp Asp Met Pro 
        115                 120                 125             


Gly Leu Ala Gln Leu Ile Asp Ile Pro Ser Met Pro Pro Ser Val Ala 
    130                 135                 140                 


Glu Asn Ala Glu Leu Phe Ala Arg Tyr Gly Leu Asp Lys Val Gln Met 
145                 150                 155                 160 


Thr Ser Leu Asp Tyr Lys Arg Lys Gln Val Asn Leu Tyr Phe Ser Asn 
                165                 170                 175     


Leu Gln Pro Glu Phe Leu Ala Pro Glu Pro Val Leu Ser Met Val Arg 
            180                 185                 190         


Glu Met Gly Leu Glu Leu Pro Gly Glu Lys Gly Leu Lys Phe Ala Arg 
        195                 200                 205             


Arg Ser Phe Ala Ile Tyr Pro Thr Leu Gly Trp Glu Ser Gly Lys Ile 
    210                 215                 220                 


Glu Arg Leu Cys Phe Ala Val Ile Ser Thr Asp Pro Gly Leu Val Pro 
225                 230                 235                 240 


Ala Pro Asp Glu Ala Asp Arg Ala Leu Phe Ser Thr Tyr Ala Asn Asn 
                245                 250                 255     


Ala Pro Tyr Ala Tyr Ala Gly Glu Lys Arg Thr Leu Val Tyr Gly Leu 
            260                 265                 270         


Thr Leu Ser Pro Thr Glu Glu Tyr Tyr Lys Leu Gly Ser Tyr Tyr Gln 
        275                 280                 285             


Ile Thr Asp Ile Gln Arg Thr Leu Leu Lys Ala Phe Asp Ala Leu Thr 
    290                 295                 300                 


Asp 
305 


<210>  7
<211>  305
<212>  PRT
<213>  Streptomyces sp. URHA0041

<400>  7

Met Ser Gly Ala Ala Glu Val Glu Arg Val Tyr Ser Ala Met Glu Glu 
1               5                   10                  15      


Ser Ala Gly Leu Leu Asp Val Ala Cys Ser Arg Glu Lys Ile Gln Pro 
            20                  25                  30          


Ile Leu Thr Ala Phe Gln Asp Val Leu Ala Asp Gly Val Ile Val Phe 
        35                  40                  45              


Ser Met Ala Asn Gly Arg His Ala Thr Glu Leu Asp Phe Ser Ile Ser 
    50                  55                  60                  


Val Pro Ala Gly His Gly Asp Pro Tyr Ala Ala Ala Leu Glu His Gly 
65                  70                  75                  80  


Leu Ile Pro Ala Thr Gly His Pro Val Gly Asp Leu Leu Ala Asp Thr 
                85                  90                  95      


Gln Lys Ala Leu Pro Val Ser Met Phe Ala Val Asp Gly Glu Val Thr 
            100                 105                 110         


Ser Gly Phe Lys Lys Thr Tyr Ala Phe Phe Pro Thr Asp Asp Met Pro 
        115                 120                 125             


Gly Leu Ala Gln Leu Ile Asp Ile Pro Ser Met Pro Pro Ser Val Ala 
    130                 135                 140                 


Glu Asn Ala Glu Leu Phe Gly Arg Tyr Gly Leu Asp Lys Val Gln Met 
145                 150                 155                 160 


Ile Ser Leu Asp Tyr Lys Lys Asn Gln Val Asn Leu Tyr Phe Ser Asn 
                165                 170                 175     


Leu Asn Pro Glu Phe Leu Gln Pro Glu Pro Val Gln Ala Met Val Arg 
            180                 185                 190         


Glu Met Gly Leu Gln Leu Pro Ala Asp Lys Gly Leu Ala Phe Ala Lys 
        195                 200                 205             


Arg Ser Phe Ala Val Tyr Pro Thr Leu Ser Trp Asp Ser Ala Lys Ile 
    210                 215                 220                 


Glu Arg Leu Cys Phe Ala Val Ile Ser Thr Asp Pro Thr Leu Ala Pro 
225                 230                 235                 240 


Ala Gln Glu Gln Ala Asp Leu Asp Leu Phe Ser Thr Tyr Ala Asn Asn 
                245                 250                 255     


Ala Pro Tyr Ala Tyr Ala Gly Glu Lys Arg Thr Leu Val Tyr Gly Leu 
            260                 265                 270         


Thr Leu Ser Pro Ser Glu Glu Tyr Tyr Lys Leu Gly Ser Tyr Tyr Gln 
        275                 280                 285             


Ile Ser Asp Ile Gln Arg Lys Leu Leu Lys Ala Phe Asp Ala Leu Thr 
    290                 295                 300                 


Asp 
305 


<210>  8
<211>  305
<212>  PRT
<213>  Streptomyces sp. CNQ-509

<400>  8

Met Ser Gly Ala Ala Asp Val Glu Arg Val Tyr Ser Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Arg Leu Leu Asp Ile Thr Val Ser Arg Glu Lys Val Arg Pro 
            20                  25                  30          


Ala Leu Glu Ala Tyr His Glu Val Leu Ala Asp Ala Val Val Val Phe 
        35                  40                  45              


Ser Met Ala Ser Gly Arg Tyr Ala Thr Glu Leu Asp Phe Ser Ile Ser 
    50                  55                  60                  


Val Pro Ala Glu Ala Gly Asp Pro Tyr Arg Val Ala Leu Ala Lys Gly 
65                  70                  75                  80  


Leu Thr Pro Arg Thr Asp His Pro Val Gly Arg Leu Leu Ala Asp Thr 
                85                  90                  95      


Gln Glu His Cys Pro Val Ser Met Phe Ala Phe Asp Gly Glu Ile Thr 
            100                 105                 110         


Gly Gly Phe Lys Lys Thr Tyr Ala Phe Phe Pro Thr Asn Asp Leu Gln 
        115                 120                 125             


Ser Ala Ser Lys Leu Ala Glu Ile Pro Ser Met Pro Asp Ser Val Lys 
    130                 135                 140                 


Glu Asn Ala Asp Leu Phe Ala Arg Tyr Gly Leu Asp Lys Val Gln Met 
145                 150                 155                 160 


Thr Ser Ile Asp Tyr Lys Lys Lys Ala Val Asn Leu Tyr Phe Ser Glu 
                165                 170                 175     


Met Ser Pro Asp Ile Leu Gly Pro Asp Thr Val Arg Ser Met Leu Arg 
            180                 185                 190         


Asp Met Gly Leu Lys Glu Thr Gly Glu Thr Gly Leu Thr Phe Ala Arg 
        195                 200                 205             


Arg Ser Phe Ser Val Tyr Pro Thr Leu Asn Trp Glu Thr Gly Arg Ile 
    210                 215                 220                 


Glu Arg Leu Cys Phe Ala Val Ile Ser Arg Asp Pro Thr Leu Ala Pro 
225                 230                 235                 240 


Ala Glu Arg Ala Glu Asp Leu Ala Lys Phe Ser Lys Tyr Ala Asn Asn 
                245                 250                 255     


Ala Pro Tyr Ala Tyr Ala Gly Glu Ala Arg Thr Leu Val Tyr Gly Leu 
            260                 265                 270         


Thr Leu Thr Pro Arg Glu Glu Tyr Tyr Lys Leu Gly Ser Tyr Tyr Gln 
        275                 280                 285             


Ile Ser Asp Ile Gln Arg Lys Leu Leu Lys Ala Phe Asp Ser Leu Asn 
    290                 295                 300                 


Asp 
305 


<210>  9
<211>  304
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  9

Met Ser Gly Ala Lys Asp Val Glu Arg Val Tyr Ser Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Gly Leu Leu Asn Val Pro Val Ala Arg Asp Lys Ile Trp Pro 
            20                  25                  30          


Val Leu Thr Ala Tyr Gln Asp Ala Leu Ala Asp Ala Val Ile Val Phe 
        35                  40                  45              


Ser Met Ala Gly Gly Arg Arg Ser Thr Glu Leu Asp Phe Ser Ile Ser 
    50                  55                  60                  


Val Pro Thr Asp His Gly Asp Pro Phe Thr Thr Ala Leu Glu Arg Gly 
65                  70                  75                  80  


Leu Thr Glu Lys Glu Asn His Pro Val Asp Asn Leu Leu Ala Glu Leu 
                85                  90                  95      


Arg Asp Gly Phe Pro Leu Gly Met Tyr Ala Ile Asp Gly Met Val Thr 
            100                 105                 110         


Thr Gly Phe Lys Lys Ala Tyr Ala Ser Phe Pro Thr Asn Glu Pro Gln 
        115                 120                 125             


Pro Leu Thr Ala Leu Leu Asp Leu Pro Ser Met Pro Glu Ser Ala Arg 
    130                 135                 140                 


Ala Asn Ala Glu Leu Phe Ala Arg Tyr Gly Leu Asp Lys Val Gln Met 
145                 150                 155                 160 


Val Ser Val Asp Tyr Pro Lys Arg Gln Val Asn Leu Tyr Phe Ser Glu 
                165                 170                 175     


Leu Lys Ala Asp His Leu Thr Pro Glu Gln Val Lys Ala Thr Ala Ser 
            180                 185                 190         


Glu Met Gly Leu Val Glu Pro Thr Asp Met Ala Leu Asp Phe Ala Thr 
        195                 200                 205             


Gly Ser Phe Ala Val Tyr Pro Thr Leu Gly Tyr Asp Ser Asp Val Val 
    210                 215                 220                 


Asp Arg Ile Thr Tyr Ala Val Ile Ser Val Asp Pro Thr Leu Ala Pro 
225                 230                 235                 240 


Thr Thr Ser Glu Pro Glu Lys Thr Gln Ile Thr Thr Tyr Ala Asn Ser 
                245                 250                 255     


Ala Pro Tyr Ala Tyr Ala Gly Glu Asn Arg Thr Leu Val Tyr Gly Phe 
            260                 265                 270         


Thr Leu Thr Ser Lys Glu Glu Tyr Tyr Lys Leu Gly Ser Tyr Tyr Gln 
        275                 280                 285             


Ile Thr Asp Leu Gln Arg Thr Leu Val Lys Ala Phe Glu Ala Leu Asp 
    290                 295                 300                 


<210>  10
<211>  304
<212>  PRT
<213>  Streptomyces sp. CNH099

<400>  10

Met Ser Gly Ala Lys Asp Val Glu Arg Val Tyr Ser Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Gly Leu Leu Asn Val Pro Val Ala Arg Asp Lys Ile Trp Pro 
            20                  25                  30          


Val Leu Thr Ala Tyr Gln Asp Ala Leu Ala Asp Ala Val Ile Val Phe 
        35                  40                  45              


Ser Met Ala Gly Gly Arg Arg Ser Thr Glu Leu Asp Phe Ser Ile Ser 
    50                  55                  60                  


Val Pro Thr Asp His Gly Asp Pro Phe Thr Thr Ala Leu Glu Arg Gly 
65                  70                  75                  80  


Leu Thr Glu Lys Glu Asn His Pro Val Asp Asn Leu Leu Ala Glu Leu 
                85                  90                  95      


Arg Asp Gly Phe Pro Leu Gly Met Tyr Ala Ile Asp Gly Met Val Thr 
            100                 105                 110         


Thr Gly Phe Lys Lys Ala Tyr Ala Ser Phe Pro Thr Asn Glu Pro Gln 
        115                 120                 125             


Pro Leu Thr Ala Leu Leu Asp Leu Pro Ser Met Pro Glu Ser Ala Arg 
    130                 135                 140                 


Ala Asn Ala Glu Leu Phe Ala Arg Tyr Gly Leu Asp Lys Val Gln Met 
145                 150                 155                 160 


Val Ser Val Asp Tyr Pro Lys Arg Gln Val Asn Leu Tyr Phe Ser Asp 
                165                 170                 175     


Leu Asn Ala Asp His Leu Thr Pro Glu Glu Val Lys Ser Thr Ala Ser 
            180                 185                 190         


Glu Met Gly Leu Val Glu Pro Thr Asp Met Ala Leu Asp Phe Ala Thr 
        195                 200                 205             


Gly Ser Phe Ala Val Tyr Pro Thr Leu Gly Tyr Asp Ser Asp Val Val 
    210                 215                 220                 


Asp Arg Ile Thr Tyr Ala Val Ile Ser Val Asp Pro Thr Leu Ala Pro 
225                 230                 235                 240 


Thr Thr Ser Glu Pro Glu Lys Thr Gln Ile Thr Thr Tyr Ala Asn Ser 
                245                 250                 255     


Ala Pro Tyr Ala Tyr Ala Gly Glu Asn Arg Thr Leu Val Tyr Gly Phe 
            260                 265                 270         


Thr Leu Thr Ser Lys Glu Glu Tyr Tyr Lys Leu Gly Ser Tyr Tyr Gln 
        275                 280                 285             


Ile Thr Asp Leu Gln Arg Thr Leu Val Lys Ala Phe Glu Ala Leu Asp 
    290                 295                 300                 


<210>  11
<211>  304
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  11

Met Ser Gly Ala Asn Asp Val Glu Arg Val Tyr Ser Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Gly Leu Leu Asn Val Pro Val Ala Arg Asp Lys Ile Trp Pro 
            20                  25                  30          


Val Leu Thr Ala Tyr Gln Asp Ala Leu Ala Asp Ala Val Val Val Phe 
        35                  40                  45              


Ser Met Ala Gly Gly Arg Arg Ala Thr Glu Leu Asp Phe Ser Ile Ser 
    50                  55                  60                  


Val Pro Thr Asp Leu Gly Asp Pro Phe Thr Thr Ala Leu Arg Arg Gly 
65                  70                  75                  80  


Leu Thr Glu Lys Thr Asn His Pro Val Asp Asn Leu Leu Ala Glu Leu 
                85                  90                  95      


Thr Asp Gly Phe Glu Ile Gly Met Tyr Ala Ile Asp Gly Met Val Thr 
            100                 105                 110         


Thr Gly Phe Lys Lys Thr Tyr Ala Ser Phe Pro Thr Asn Glu Pro Gln 
        115                 120                 125             


Pro Leu Thr Ala Leu Leu Asp Val Pro Ser Met Pro Glu Ser Ala Arg 
    130                 135                 140                 


Ala Asn Ala Glu Leu Phe Ala Arg Tyr Gly Leu Asp Lys Val Gln Met 
145                 150                 155                 160 


Val Ser Val Asp Tyr Pro Lys Arg Gln Val Asn Leu Tyr Phe Ser Glu 
                165                 170                 175     


Leu Asp Thr Asp Tyr Leu Gln Pro Glu His Val Lys Ser Leu Ala Arg 
            180                 185                 190         


Glu Thr Gly Leu Val Glu Pro Thr Glu Met Gly Leu Asp Phe Ala Ser 
        195                 200                 205             


Gly Ser Phe Ala Val Tyr Pro Thr Leu Gly Tyr Asp Asn Asp Ile Val 
    210                 215                 220                 


Asp Arg Ile Thr Tyr Ala Val Ile Ser Val Asp Pro Thr Leu Ala Pro 
225                 230                 235                 240 


Thr Lys Ser Glu Pro Glu Val Ser Gln Leu Ser Arg Tyr Ala Thr Ser 
                245                 250                 255     


Ala Pro Tyr Ala Tyr Ala Gly Glu Asn Arg Thr Leu Val Tyr Gly Val 
            260                 265                 270         


Thr Leu Thr Ser Lys Glu Glu Tyr Tyr Lys Leu Gly Ser Tyr Tyr Gln 
        275                 280                 285             


Ile Thr Asp Leu Gln Arg Thr Leu Val Lys Ala Phe Glu Ala Leu Asp 
    290                 295                 300                 


<210>  12
<211>  304
<212>  PRT
<213>  Unknown

<220>
<223>  Unknown

<400>  12

Met Ser Gly Ala Asn Asp Val Glu Arg Val Tyr Ser Ala Met Glu Glu 
1               5                   10                  15      


Ala Ala Gly Leu Leu Gly Val Pro Val Ala Arg Glu Lys Val Arg Pro 
            20                  25                  30          


Val Leu Thr Ala Tyr Gln Asp Ala Leu Ala Asp Ala Val Val Val Phe 
        35                  40                  45              


Ser Met Ala Gly Gly Arg Arg Ala Thr Glu Leu Asp Phe Ser Ile Ser 
    50                  55                  60                  


Val Pro Thr Asp His Gly Asp Pro Phe Thr Thr Ala Leu Gln Arg Gly 
65                  70                  75                  80  


Leu Thr Glu Lys Thr Gly His Pro Val Asp Asn Leu Leu Ala Glu Leu 
                85                  90                  95      


Arg Glu Gly Phe Pro Leu Gly Met Tyr Ala Ile Asp Gly Met Val Ser 
            100                 105                 110         


Thr Gly Phe Lys Lys Thr Tyr Ala Ser Phe Pro Thr Asn Glu Pro Gln 
        115                 120                 125             


Pro Leu Asp Asp Leu Leu Asp Val Pro Ser Met Pro Ala Ser Ala Arg 
    130                 135                 140                 


Ala Asn Ala Lys Leu Phe Ala Asn Tyr Gly Leu Asp Lys Val Gln Met 
145                 150                 155                 160 


Val Ser Val Asp Tyr Pro Lys Arg Gln Val Asn Leu Tyr Phe Ser Glu 
                165                 170                 175     


Leu Asn Thr Asp Tyr Leu Gln Pro Ala Gln Val Lys Ala Leu Ala Ala 
            180                 185                 190         


Glu Met Gly Leu Ile Glu Pro Ser Glu Leu Gly Leu Glu Phe Ala Lys 
        195                 200                 205             


Gly Ser Phe Ala Val Tyr Pro Thr Leu Ser Tyr Asp Thr Asp Ala Ser 
    210                 215                 220                 


Asp Arg Leu Cys Leu Ala Val Ile Ser Ser Asp Pro Thr Leu Ala Pro 
225                 230                 235                 240 


Thr Thr Ser Glu Pro Glu Val Thr Gln Phe Ser Thr Tyr Ala Asn Asn 
                245                 250                 255     


Ala Pro Tyr Ala Tyr Ala Gly Glu Asn Arg Thr Leu Val Tyr Gly Leu 
            260                 265                 270         


Thr Leu Thr Pro Lys Glu Glu Tyr Tyr Lys Leu Gly Ser Tyr Tyr Gln 
        275                 280                 285             


Ile Thr Asp Tyr Gln Arg Lys Leu Val Lys Ala Phe Glu Ala Leu Asp 
    290                 295                 300                 


<210>  13
<211>  306
<212>  PRT
<213>  Streptomyces sp. 303MFCol5.2

<400>  13

Met Ser Lys Ala Thr Glu Val Asp Arg Val Tyr Ala Ala Val Glu Lys 
1               5                   10                  15      


Ala Ala Ala Leu Ala Gly Thr Thr Cys Ala Gly Asp Lys Val Arg Pro 
            20                  25                  30          


Val Leu Thr Gly His Gln Asp Leu Leu Asp Glu Ala Val Ile Val Phe 
        35                  40                  45              


Ser Met Thr Ala Ser Gly Ser His Ser Gly Gly Leu Asp Leu Ser Met 
    50                  55                  60                  


Thr Val Pro Ala Glu His Val Asp Pro Tyr Ser Phe Ala Leu Ser Glu 
65                  70                  75                  80  


Gly Leu Ile Glu Pro Thr Asp His Pro Val Gly Ser Val Ile Ser Asp 
                85                  90                  95      


Phe Gln Glu Arg Phe Pro Ile Gly Met Tyr Gly Ile Asp Val Asp Val 
            100                 105                 110         


Ala Gly Gly Phe Lys Lys Ala Tyr Ala Ala Phe Pro Ser Asn Asp Leu 
        115                 120                 125             


Arg Glu Leu Lys Gln Leu Phe Asp Leu Pro Ser Met Pro Ser Ala Ala 
    130                 135                 140                 


Ala Glu Asn Ala Glu Leu Phe Ala Arg Tyr Gly Leu Asp Arg Val Thr 
145                 150                 155                 160 


Gly Val Ser Val Asp Tyr Lys Arg His Glu Leu Asn Leu Tyr Cys Asp 
                165                 170                 175     


Arg Ala Thr Thr Glu Pro Leu Asp Pro Asp Tyr Val Gln Ser Met Leu 
            180                 185                 190         


Arg Asp Met Gly Leu Lys Glu Ala Ser Glu Gln Gly Leu Glu Phe Ala 
        195                 200                 205             


Lys Lys Thr Phe Ala Ile Tyr Pro Thr Leu Asn Trp Asp Ser Ser Glu 
    210                 215                 220                 


Ile Val Arg Ile Cys Phe Ala Val Ile Thr Thr Asp Pro Ala Thr Thr 
225                 230                 235                 240 


Pro Thr Arg Ser Glu Pro Glu Leu Gly Gln Met Trp Glu Tyr Ala Asn 
                245                 250                 255     


Thr Ala Pro Tyr Ala Tyr Val Gly Glu Gln Arg Ala Leu Val Tyr Gly 
            260                 265                 270         


Leu Ala Leu Ser Pro Glu Lys Glu Tyr Tyr Lys Leu Gly Ala Tyr Tyr 
        275                 280                 285             


Gln Ile Ser Asp Tyr Gln Arg Lys Leu Val Lys Ala Phe Asp Ala Leu 
    290                 295                 300                 


Pro Glu 
305     


<210>  14
<211>  378
<212>  PRT
<213>  Streptomyces niveus

<400>  14

Met Cys Val Pro Gly Ser Arg Ala Arg Arg Pro Gly Ser Arg Gly Trp 
1               5                   10                  15      


Leu Glu Arg Thr Ala Lys Pro Ala Pro Thr Arg Gly Thr Val Gly Ala 
            20                  25                  30          


Lys Val Arg Ser Gln Thr Trp Glu Arg Arg Ala Pro Gly Ala Thr Thr 
        35                  40                  45              


Val Thr Cys Pro Val Gln Gly Arg Ser Thr Gly Pro Ile Gln Ala Asp 
    50                  55                  60                  


Ile Gln Asp Arg His Val Gly Asp Ser Met Ser Gly Ala Ala Asp Val 
65                  70                  75                  80  


Glu Arg Val Tyr Ser Ala Met Glu Arg Ala Ala Gly Leu Leu Asp Leu 
                85                  90                  95      


Thr Cys Ala Arg Glu Lys Ile Leu Pro Ile Leu Thr Ala Tyr Lys Glu 
            100                 105                 110         


Ala Leu Ala Asp Ser Val Ile Val Phe Ser Met Ser Gly Gly Asp His 
        115                 120                 125             


Ser Ala Glu Leu Asp Phe Ser Phe Thr Ile Pro Ser Gly Asp Val Asp 
    130                 135                 140                 


Pro Tyr Ala Phe Gly Pro Ser Thr Gly Ile Pro Thr Glu Thr Asp His 
145                 150                 155                 160 


Pro Ile Ala Ser Leu Leu Ser Asp Thr Gly Glu Arg Cys Pro Val Ala 
                165                 170                 175     


Met Tyr Gly Val Asp Gly Glu Val Ser Gly Gly Phe Lys Lys Thr Tyr 
            180                 185                 190         


Ala Ala Phe Pro Ile Asn Asp Leu Leu Asp Leu Ser Lys Leu Val Ala 
        195                 200                 205             


Val Pro Ser Met Pro Pro Ala Val Ala Glu Asn Ala Glu Leu Phe Ala 
    210                 215                 220                 


Arg Tyr Gly Leu Asp Lys Val Gln Gly Ile Ser Ile Asp Tyr Gln Arg 
225                 230                 235                 240 


Lys Gln Val Asn Leu Tyr Cys Gly Asp Ile Pro Ala Glu Ser Leu Glu 
                245                 250                 255     


Pro Glu Thr Val Arg Ser Met Leu Arg Glu Met Gly Leu Arg Glu Pro 
            260                 265                 270         


Ser Glu Glu Gly Leu Glu Phe Val Arg Lys Ser Phe Ala Val Tyr Pro 
        275                 280                 285             


Thr Leu Ser Trp Asp Ser Ser Arg Ile Glu Arg Ile Cys Phe Ala Val 
    290                 295                 300                 


Ile Ser Thr Asp Pro Thr Leu Ala Pro Thr Arg Val Glu Ser Asp Val 
305                 310                 315                 320 


Ala Leu Phe Ser Lys Tyr Ala Asn Asn Ala Pro Tyr Ala Tyr Ala Gly 
                325                 330                 335     


Glu Arg Arg Thr Leu Ile Tyr Gly Leu Ala Val Ser Pro Thr Lys Glu 
            340                 345                 350         


Tyr Ile Lys Leu Gly Ser Tyr Tyr Gln Ile Ser Asp His Gln Arg Lys 
        355                 360                 365             


Leu Val Lys Ala Phe Asp Ala Leu Glu Asp 
    370                 375             


<210>  15
<211>  311
<212>  PRT
<213>  Streptomyces sp. CNH287

<400>  15

Met Tyr Gly Gly Thr Glu Val Glu Glu Val Tyr Ser Ala Leu Glu Lys 
1               5                   10                  15      


Ser Ala Gly Leu Val Gly Val Pro Cys Asn Arg Asp Lys Val Trp Pro 
            20                  25                  30          


Ala Leu Ser Thr Tyr Gln Asp Ala Leu Gly Glu Ala Val Ile Val Phe 
        35                  40                  45              


Ser Val Ala Thr Asp Glu Arg His Ala Gly Glu Leu Asp Tyr Thr Ile 
    50                  55                  60                  


Thr Val Pro Thr Gly Gly Ala Asp Pro Tyr Ala Leu Ala Leu Ala Lys 
65                  70                  75                  80  


Gly Leu Thr Pro Glu Thr Asp His Pro Val Gly Thr Leu Leu Ala Gly 
                85                  90                  95      


Val Gln Glu Arg Cys Pro Val Ala Gly Tyr Ala Val Asp Cys Gly Val 
            100                 105                 110         


Val Gly Gly Phe Lys Lys Ile Tyr Ser Phe Phe Pro Gln Asp Asp Leu 
        115                 120                 125             


Gln Gly Leu Ala Lys Leu Ala Glu Ile Pro Ser Met Pro Arg Ala Leu 
    130                 135                 140                 


Ala Glu Asn Ala Ala Leu Phe Ala Arg His Gly Leu Asp His Lys Val 
145                 150                 155                 160 


Thr Met Leu Gly Ile Asp Tyr Gln Arg Glu Ser Val Asn Leu Tyr Phe 
                165                 170                 175     


Gly Lys Leu Pro Glu Glu Cys Leu Gln Pro Asp Ser Ile Arg Ala Ile 
            180                 185                 190         


Leu Arg Asp Ile Gly Leu Pro Glu Pro Thr Glu Pro Met Leu Glu Phe 
        195                 200                 205             


Ala Arg Lys Ser Phe Ala Ile Tyr Val Thr Leu Ser Trp Asp Ala Ala 
    210                 215                 220                 


Lys Val Glu Arg Ile Cys Phe Ala Val Pro Pro Gly Arg Asp Leu Ile 
225                 230                 235                 240 


Thr Leu Asp Pro Ser Ala Leu Pro Ala Arg Ile Ala Pro Glu Ile Glu 
                245                 250                 255     


His Phe Ala Arg Asn Ser Pro Tyr Ala Tyr Pro Gly Asp Arg Met Leu 
            260                 265                 270         


Val Tyr Gly Val Thr Trp Ser Pro Glu Glu Glu Tyr Tyr Lys Leu Gly 
        275                 280                 285             


Ser Tyr Tyr Gln Leu Pro Val Gln Thr Arg Lys Leu Leu Val Ala Phe 
    290                 295                 300                 


Asp Ser Val Lys Asp Gln Glu 
305                 310     


